Mouse Imaging

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The Mouse Imaging Program (MIP) is a large scale imaging resource supported in part through an NCI U24 grant. The resource provides the larger Harvard/MIT research community with access to state-of-the-art in vivo imaging technologies including high resolution magnetic resonance (MR), computed tomography (CT), positron emission tomography-CT (PET-CT), single photon emission computed tomography-CT (SPECT-CT), fluorescence mediated tomography (FMT) and bioluminescence imaging (BLI). The integrated Program also provides mouse holding facilities for serial imaging, surgery, anesthesia, veterinary care and imaging agents. Image reconstruction, 3D display, fusion, quantitative image analysis and server access are also available. The Program offers periodic training and performs its own research in order to continue to improve existing imaging technologies. Imaging requests from investigators of the Mouse Model of Human Cancers Consortia and recipients of NCI grants are prioritized.

Mipmodalities_tmp IVM MRI BioComputing PET-CT SPECT-CT Pathology Radiochem Mouse Husbandry Optical FRI BLI Surgery

Recent Publications (more...)

Jain IH, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz GR, Ast T, Wang H, Schleifer G, Stepanova A, Brepoels K, Schoonjans L, Carmeliet P, Galkin A, Ichinose F, Zapol WM, Mootha VK
Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation.
Cell Metab. 2019;:ePub - PMID: 31402314 - DOI: 10.1016/j.cmet.2019.07.006
Wang C, Keliher E, Zeller MWG, Wojtkiewicz GR, Aguirre AD, Buckbinder L, Kim HY, Chen J, Maresca K, Ahmed MS, Motlagh NJ, Nahrendorf M, Chen JW
An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo.
Proc Natl Acad Sci U S A. 2019;116(24):11966-11971 - PMID: 31123149 - PMCID: PMC6575581 - DOI: 10.1073/pnas.1818434116
Morini E, Gao D, Montgomery CM, Salani M, Mazzasette C, Krussig TA, Swain B, Dietrich P, Narasimhan J, Gabbeta V, Dakka A, Hedrick J, Zhao X, Weetall M, Naryshkin NA, Wojtkiewicz GG, Ko CP, Talkowski ME, Dragatsis I, Slaugenhaupt SA
ELP1 Splicing Correction Reverses Proprioceptive Sensory Loss in Familial Dysautonomia.
Am J Hum Genet. 2019;104(4):638-650 - PMID: 30905397 - PMCID: PMC6451698 - DOI: 10.1016/j.ajhg.2019.02.009
Ippen FM, Alvarez-Breckenridge CA, Kuter BM, Fink AL, Bihun IV, Lastrapes M, Penson T, Schmidt SP, Wojtkiewicz GR, Ning J, Subramanian M, Giobbie-Hurder A, Martinez-Lage M, Carter SL, Cahill DP, Wakimoto H, Brastianos PK
The Dual PI3K/mTOR Pathway Inhibitor GDC-0084 Achieves Antitumor Activity in <i>PIK3CA</i>-Mutant Breast Cancer Brain Metastases.
Clin Cancer Res. 2019;25(11):3374-3383 - PMID: 30796030 - PMCID: PMC6685218 - DOI: 10.1158/1078-0432.CCR-18-3049

Recent News (more...)

2015-06-24: Recent CSB work has been published on BPoD – Biomedical Picture of the Day.
2012-12-11: "Imaging Early MS" - An Interview with John Chen, M.D., Ph.D. by Dana Foundation (pdf)
2012-09-10: Dont forget to register for the upcoming Harvard CME course on Molecular Imaging. The course is being chaired by Drs. Frangioni and Weissleder and features over 30 invited speakers covering all topics of molecular imaging. More information can be found here.
2012-04-13: "Magnetic Nanoparticles Predict Diabetes Onset" - HMS Focus highlights describes developed at CSB a magnetic nanoparticle-based MRI technique for predicting whether and when subjects with a genetic predisposition for diabetes will develop the disease. (pdf)