Mouse Imaging Program
The Mouse Imaging Program (MIP) is a large scale imaging resource within the Center established to provide the larger Boston research community with access to state-of-the-art in vivo imaging technologies including high resolution magnetic resonance (MR), computed tomography (CT), positron emission tomography-CT (PET-CT), bioluminescence imaging (BLI), fluorescence imaging and intravital microscopy. The integrated Program also provides mouse holding facilities for serial imaging, surgery, anesthesia, veterinary care and access to custom synthesized imaging agents. A pathology core is another integral part of the resource. Image reconstruction, 3D display, fusion, quantitative image analysis, deep learning/AI services are also available. All imaging archived and accessible via HIPA compliant servers. The Program offers periodic training and performs its own research in order to continue to improve existing imaging technologies.
The Core offers the following services:
- PET-CT and µ-CT
- Bioluminescence imaging
- Fluorescent reflectance optical imaging
- Intravital microscopy
- Radiochemistry and chemistry
- Image analysis, AI
To request services submit Imaging request.
Panizzi P, Krohn-Grimberghe M, Keliher E, Ye YX, Grune J, Frodermann V, Sun Y, Muse CG, Bushey K, Iwamoto Y, van Leent MMT, Meerwaldt A, Toner YC, Munitz J, Maier A, Soultanidis G, Calcagno C, Pérez-Medina C, Carlucci G, Riddell KP, Barney S, Horne G, Anderson B, Maddur-Appajaiah A, Verhamme IM, Bock PE, Wojtkiewicz GR, Courties G, Swirski FK, Church WR, Walz PH, Tillson DM, Mulder WJM, Nahrendorf M Multimodal imaging of bacterial-host interface in mice and piglets with Staphylococcus aureus endocarditis. Sci Transl Med. 2020;12(568):ePub - PMID: 33148623 - DOI: 10.1126/scitranslmed.aay2104
Xiao L, Salem JE, Clauss S, Hanley A, Bapat A, Hulsmans M, Iwamoto Y, Wojtkiewicz G, Cetinbas M, Schloss MJ, Tedeschi J, Lebrun-Vignes B, Lundby A, Sadreyev RI, Moslehi JJ, Nahrendorf M, Ellinor PT, Milan DJ Ibrutinib-Mediated Atrial Fibrillation Due to Inhibition of CSK. Circulation. 2020;142(25):2443-2455 - PMID: 33092403 - DOI: 10.1161/CIRCULATIONAHA.120.049210
Krohn-Grimberghe M, Mitchell MJ, Schloss MJ, Khan OF, Courties G, Guimaraes PPG, Rohde D, Cremer S, Kowalski PS, Sun Y, Tan M, Webster J, Wang K, Iwamoto Y, Schmidt SP, Wojtkiewicz GR, Nayar R, Frodermann V, Hulsmans M, Chung A, Hoyer FF, Swirski FK, Langer R, Anderson DG, Nahrendorf M Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche. Nat Biomed Eng. 2020;4(11):1076-1089 - PMID: 33020600 - PMCID: PMC7655681 - DOI: 10.1038/s41551-020-00623-7
Ng TSC, Gunda V, Li R, Prytyskach M, Iwamoto Y, Kohler RH, Parangi S, Weissleder R, Miller MA Detecting Immune Response to Therapies Targeting PDL1 and BRAF by Using Ferumoxytol MRI and Macrin in Anaplastic Thyroid Cancer. Radiology. 2021;298(1):123-132 - PMID: 33107799 - PMCID: PMC7771993 - DOI: 10.1148/radiol.2020201791
- More publications ...
Dont forget to register for the upcoming Harvard CME course on Molecular Imaging. The course is being chaired by Drs. Frangioni and Weissleder and features over 30 invited speakers covering all topics of molecular imaging. More information can be found here.
"Magnetic Nanoparticles Predict Diabetes Onset" - HMS Focus highlights describes developed at CSB a magnetic nanoparticle-based MRI technique for predicting whether and when subjects with a genetic predisposition for diabetes will develop the disease. (pdf)
CSB paper "Dextran-Coated Iron Oxide Nanoparticles: A Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy" is #3 on the list of Most Read Articles in Accounts of Chemical Research.