Mouse Imaging Program

The Mouse Imaging Program (MIP) is a large scale imaging resource within the Center established to provide the larger Boston research community with access to state-of-the-art in vivo imaging technologies including high resolution magnetic resonance (MR), computed tomography (CT), positron emission tomography-CT (PET-CT), bioluminescence imaging (BLI), fluorescence imaging and intravital microscopy. The integrated Program also provides mouse holding facilities for serial imaging, surgery, anesthesia, veterinary care and access to custom synthesized imaging agents. A pathology core is another integral part of the resource. Image reconstruction, 3D display, fusion, quantitative image analysis, deep learning/AI services are also available. All imaging archived and accessible via HIPA compliant servers. The Program offers periodic training and performs its own research in order to continue to improve existing imaging technologies.

The Core offers the following services: 

  • MRI
  • PET-CT and µ-CT 
  • Bioluminescence imaging
  • Fluorescent reflectance optical imaging
  • Intravital microscopy 
  • Radiochemistry and chemistry
  • Pathology
  • Surgery
  • Image analysis, AI

To request services submit Imaging request.

Imaging requests from investigators of the Mouse Model of Human Cancers Consortia and recipients of NCI grants are prioritized.

Recent Publications

  • van Leent MMT, Beldman TJ, Toner YC, Lameijer MA, Rother N, Bekkering S, Teunissen AJP, Zhou X, van der Meel R, Malkus J, Nauta SA, Klein ED, Fay F, Sanchez-Gaytan BL, Pérez-Medina C, Kluza E, Ye YX, Wojtkiewicz G, Fisher EA, Swirski FK, Nahrendorf M, Zhang B, Li Y, Zhang B, Joosten LAB, Pasterkamp G, Boltjes A, Fayad ZA, Lutgens E, Netea MG, Riksen NP, Mulder WJM, Duivenvoorden R Prosaposin mediates inflammation in atherosclerosis. Sci Transl Med. 2021;13(584):ePub - PMID: 33692130 - PMCID: PMC8209679 - DOI: 10.1126/scitranslmed.abe1433

  • Stewart-Ornstein J, Iwamoto Y, Miller MA, Prytyskach MA, Ferretti S, Holzer P, Kallen J, Furet P, Jambhekar A, Forrester WC, Weissleder R, Lahav G p53 dynamics vary between tissues and are linked with radiation sensitivity. Nat Commun. 2021;12(1):898 - PMID: 33563973 - PMCID: PMC7873198 - DOI: 10.1038/s41467-021-21145-z

  • Panizzi P, Krohn-Grimberghe M, Keliher E, Ye YX, Grune J, Frodermann V, Sun Y, Muse CG, Bushey K, Iwamoto Y, van Leent MMT, Meerwaldt A, Toner YC, Munitz J, Maier A, Soultanidis G, Calcagno C, Pérez-Medina C, Carlucci G, Riddell KP, Barney S, Horne G, Anderson B, Maddur-Appajaiah A, Verhamme IM, Bock PE, Wojtkiewicz GR, Courties G, Swirski FK, Church WR, Walz PH, Tillson DM, Mulder WJM, Nahrendorf M Multimodal imaging of bacterial-host interface in mice and piglets with Staphylococcus aureus endocarditis. Sci Transl Med. 2020;12(568):ePub - PMID: 33148623 - PMCID: PMC7818516 - DOI: 10.1126/scitranslmed.aay2104

  • Wang C, Cheng D, Jalali Motlagh N, Kuellenberg EG, Wojtkiewicz GR, Schmidt SP, Stocker R, Chen JW Highly Efficient Activatable MRI Probe to Sense Myeloperoxidase Activity. J Med Chem. 2021;64(9):5874-5885 - PMID: 33945286 - DOI: 10.1021/acs.jmedchem.1c00038

  • More publications ...

News

2015-06-24:

Recent CSB work has been published on BPoD – Biomedical Picture of the Day.

2012-12-11:

"Imaging Early MS" - An Interview with John Chen, M.D., Ph.D. by Dana Foundation (pdf)

2012-09-10:

Dont forget to register for the upcoming Harvard CME course on Molecular Imaging. The course is being chaired by Drs. Frangioni and Weissleder and features over 30 invited speakers covering all topics of molecular imaging. More information can be found here.

2012-04-13:

"Magnetic Nanoparticles Predict Diabetes Onset" - HMS Focus highlights describes developed at CSB a magnetic nanoparticle-based MRI technique for predicting whether and when subjects with a genetic predisposition for diabetes will develop the disease. (pdf)