Mouse Imaging

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The Mouse Imaging Program (MIP) is a large scale imaging resource supported in part through an NCI U24 grant. The resource provides the larger Harvard/MIT research community with access to state-of-the-art in vivo imaging technologies including high resolution magnetic resonance (MR), computed tomography (CT), positron emission tomography-CT (PET-CT), single photon emission computed tomography-CT (SPECT-CT), fluorescence mediated tomography (FMT) and bioluminescence imaging (BLI). The integrated Program also provides mouse holding facilities for serial imaging, surgery, anesthesia, veterinary care and imaging agents. Image reconstruction, 3D display, fusion, quantitative image analysis and server access are also available. The Program offers periodic training and performs its own research in order to continue to improve existing imaging technologies. Imaging requests from investigators of the Mouse Model of Human Cancers Consortia and recipients of NCI grants are prioritized.

Mipmodalities_tmp IVM MRI BioComputing PET-CT SPECT-CT Pathology Radiochem Mouse Husbandry Optical FRI BLI Surgery

Recent Publications (more...)

Engblom C*, Pfirschke C*, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ
Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils
Science. 2017;358:eaal5081 - PMID: 29191879 - DOI: 10.1126/science.aal5081
King KR, Aguirre AD, Ye YX, Sun Y, Roh JD, Ng Jr RP, Kohler RH, Arlauckas SP, Iwamoto Y, Savol A, Sadreyev RI, Kelly M, Fitzgibbons TP, Fitzgerald KA, Mitchison T, Libby P, Nahrendorf M, Weissleder R
IRF3 and type I interferons fuel a fatal response to myocardial infarction
Nature Med. 2017;23(12):1481-1487 - PMID: 29106401 - DOI: 10.1038/nm.4428
Kitano K, Schwartz DM, Zhou H, Gilpin SE, Wojtkiewicz GR, Ren X, Sommer CA, Capilla AV, Mathisen DJ, Goldstein AM, Mostoslavsky G, Ott HC
Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts.
Nat Commun. 2017;8(1):765 - PMID: 29018244 - PMCID: PMC5635127 - DOI: 10.1038/s41467-017-00779-y
Miller MA, Kim E, Cuccarese MF, Plotkin AL, Prytyskach M, Kohler RH, Pittet MJ, Weissleder R
Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease
Chem Commun. 2017;54(1):42-45 - PMID: 29185561 - PMCID: PMC5736449 - DOI: 10.1039/c7cc07581b

Recent News (more...)

2015-06-24: Recent CSB work has been published on BPoD – Biomedical Picture of the Day.
2012-12-11: "Imaging Early MS" - An Interview with John Chen, M.D., Ph.D. by Dana Foundation (pdf)
2012-09-10: Dont forget to register for the upcoming Harvard CME course on Molecular Imaging. The course is being chaired by Drs. Frangioni and Weissleder and features over 30 invited speakers covering all topics of molecular imaging. More information can be found here.
2012-04-13: "Magnetic Nanoparticles Predict Diabetes Onset" - HMS Focus highlights describes developed at CSB a magnetic nanoparticle-based MRI technique for predicting whether and when subjects with a genetic predisposition for diabetes will develop the disease. (pdf)