Mouse Imaging Program
The Mouse Imaging Program (MIP) is a large scale imaging resource within the Center established to provide the larger Boston research community with access to state-of-the-art in vivo imaging technologies including high resolution magnetic resonance (MR), computed tomography (CT), positron emission tomography-CT (PET-CT), bioluminescence imaging (BLI), fluorescence imaging and intravital microscopy. The integrated Program also provides mouse holding facilities for serial imaging, surgery, anesthesia, veterinary care and access to custom synthesized imaging agents. A pathology core is another integral part of the resource. Image reconstruction, 3D display, fusion, quantitative image analysis, deep learning/AI services are also available. All imaging archived and accessible via HIPAA compliant servers. The Program offers periodic training and performs its own research in order to continue to improve existing imaging technologies.
The Core offers the following services:
- MRI
- PET-CT and µ-CT
- Bioluminescence imaging
- Fluorescent reflectance optical imaging
- Intravital microscopy
- Radiochemistry and chemistry
- Pathology
- Surgery
- Image analysis, AI
To request services submit Imaging request.
Imaging requests from investigators of the Mouse Model of Human Cancers Consortia and recipients of NCI grants are prioritized.
Recent Publications
Hulsmans M, Schloss MJ, Lee IH, Bapat A, Iwamoto Y, Vinegoni C, Paccalet A, Yamazoe M, Grune J, Pabel S, Momin N, Seung H, Kumowski N, Pulous FE, Keller D, Bening C, Green U, Lennerz JK, Mitchell RN, Lewis A, Casadei B, Iborra-Egea O, Bayes-Genis A, Sossalla S, Ong CS, Pierson RN, Aster JC, Rohde D, Wojtkiewicz GR, Weissleder R, Swirski FK, Tellides G, Tolis G, Melnitchouk S, Milan DJ, Ellinor PT, Naxerova K, Nahrendorf M Recruited macrophages elicit atrial fibrillation. Science. 2023;381(6654):231-239 - PMID: 37440641 - PMCID: PMC10448807 - DOI: 10.1126/science.abq3061
Kiss MG, Mindur JE, Yates AG, Lee D, Fullard JF, Anzai A, Poller WC, Christie KA, Iwamoto Y, Roudko V, Downey J, Chan CT, Huynh P, Janssen H, Ntranos A, Hoffmann JD, Jacob W, Goswami S, Singh S, Leppert D, Kuhle J, Kim-Schulze S, Nahrendorf M, Kleinstiver BP, Probert F, Roussos P, Swirski FK, McAlpine CS Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis. Immunity. 2023;56(7):1502-1514.e8 - PMID: 37160117 - DOI: 10.1016/j.immuni.2023.04.013
Gustafsson K, Rhee C, Frodermann V, Scadden EW, Li D, Iwamoto Y, Palchaudhuri R, Hyzy S, Boitano A, Nahrendorf M, Scadden DT Clearing and replacing tissue-resident myeloid cells with an anti-CD45-antibody-drug conjugate. Blood Adv. 2023;:ePub - PMID: 37748049 - DOI: 10.1182/bloodadvances.2023010561
- More publications ...
News
Recent CSB work has been published on BPoD – Biomedical Picture of the Day.
"Imaging Early MS" - An Interview with John Chen, M.D., Ph.D. by Dana Foundation (pdf)
Dont forget to register for the upcoming Harvard CME course on Molecular Imaging. The course is being chaired by Drs. Frangioni and Weissleder and features over 30 invited speakers covering all topics of molecular imaging. More information can be found here.
"Magnetic Nanoparticles Predict Diabetes Onset" - HMS Focus highlights describes developed at CSB a magnetic nanoparticle-based MRI technique for predicting whether and when subjects with a genetic predisposition for diabetes will develop the disease. (pdf)
CSB paper "Dextran-Coated Iron Oxide Nanoparticles: A Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy" is #3 on the list of Most Read Articles in Accounts of Chemical Research.