Mouse Imaging Program

The Mouse Imaging Program (MIP) is a large scale imaging resource within the Center established to provide the larger Boston research community with access to state-of-the-art in vivo imaging technologies including high resolution magnetic resonance (MR), computed tomography (CT), positron emission tomography-CT (PET-CT), bioluminescence imaging (BLI), fluorescence imaging and intravital microscopy. The integrated Program also provides mouse holding facilities for serial imaging, surgery, anesthesia, veterinary care and access to custom synthesized imaging agents. A pathology core is another integral part of the resource. Image reconstruction, 3D display, fusion, quantitative image analysis, deep learning/AI services are also available. All imaging archived and accessible via HIPA compliant servers. The Program offers periodic training and performs its own research in order to continue to improve existing imaging technologies.

The Core offers the following services: 

  • MRI
  • PET-CT and µ-CT 
  • Bioluminescence imaging
  • Fluorescent reflectance optical imaging
  • Intravital microscopy 
  • Radiochemistry and chemistry
  • Pathology
  • Surgery
  • Image analysis, AI

To request services submit Imaging request.

Imaging requests from investigators of the Mouse Model of Human Cancers Consortia and recipients of NCI grants are prioritized.

Recent Publications

  • Luthria G, Li R, Wang S, Prytyskach M, Kohler RH, Lauffenburger DA, Mitchison TJ, Weissleder R, Miller MA In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells. Nat Commun. 2020;11:3521 - PMID: 32665556 - PMCID: PMC7360550 - DOI: 10.1038/s41467-020-17147-y

  • Wang SJ, Li R, Ng TSC, Luthria G, Oudin MJ, Prytyskach M, Kohler RH, Weissleder R, Lauffenburger DA, Miller MA Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy. Sci Adv. 2020;6(21):ePub - PMID: 32937338 - PMCID: PMC7244320 - DOI: 10.1126/sciadv.aaz8521

  • Cremer S, Schloss MJ, Vinegoni C, Foy BH, Zhang S, Rohde D, Hulsmans M, Fumene Feruglio P, Schmidt S, Wojtkiewicz G, Higgins JM, Weissleder R, Swirski FK, Nahrendorf M Diminished Reactive Hematopoiesis and Cardiac Inflammation in a Mouse Model of Recurrent Myocardial Infarction. J Am Coll Cardiol. 2020;75(8):901-915 - PMID: 32130926 - PMCID: PMC7254576 - DOI: 10.1016/j.jacc.2019.12.056

  • Liu Z, Ahn MH, Kurokawa T, Ly A, Zhang G, Wang F, Yamada T, Sadagopan A, Cheng J, Ferrone CR, Liss AS, Honselmann KC, Wojtkiewicz GR, Ferrone S, Wang X A fast, simple, and cost-effective method of expanding patient-derived xenograft mouse models of pancreatic ductal adenocarcinoma. J Transl Med. 2020;18(1):255 - PMID: 32580742 - PMCID: PMC7315507 - DOI: 10.1186/s12967-020-02414-9

  • More publications ...

News

2015-06-24: Recent CSB work has been published on BPoD – Biomedical Picture of the Day.
2012-12-11: "Imaging Early MS" - An Interview with John Chen, M.D., Ph.D. by Dana Foundation (pdf)
2012-09-10: Dont forget to register for the upcoming Harvard CME course on Molecular Imaging. The course is being chaired by Drs. Frangioni and Weissleder and features over 30 invited speakers covering all topics of molecular imaging. More information can be found here.
2012-04-13: "Magnetic Nanoparticles Predict Diabetes Onset" - HMS Focus highlights describes developed at CSB a magnetic nanoparticle-based MRI technique for predicting whether and when subjects with a genetic predisposition for diabetes will develop the disease. (pdf)