Mouse Imaging Program

The Mouse Imaging Program (MIP) is a large scale imaging resource within the Center established to provide the larger Boston research community with access to state-of-the-art in vivo imaging technologies including high resolution magnetic resonance (MR), computed tomography (CT), positron emission tomography-CT (PET-CT), bioluminescence imaging (BLI), fluorescence imaging and intravital microscopy. The integrated Program also provides mouse holding facilities for serial imaging, surgery, anesthesia, veterinary care and access to custom synthesized imaging agents. A pathology core is another integral part of the resource. Image reconstruction, 3D display, fusion, quantitative image analysis, deep learning/AI services are also available. All imaging archived and accessible via HIPA compliant servers. The Program offers periodic training and performs its own research in order to continue to improve existing imaging technologies.

The Core offers the following services: 

  • MRI
  • PET-CT and µ-CT 
  • Bioluminescence imaging
  • Fluorescent reflectance optical imaging
  • Intravital microscopy 
  • Radiochemistry and chemistry
  • Pathology
  • Surgery
  • Image analysis, AI

To request services submit Imaging request.

Imaging requests from investigators of the Mouse Model of Human Cancers Consortia and recipients of NCI grants are prioritized.

Recent Publications

  • Ko J, Wilkovitsch M, Oh J, Kohler RH, Bolli E, Pittet MJ, Vinegoni C, Sykes DB, Mikula H, Weissleder R, Carlson JCT Spatiotemporal multiplexed immunofluorescence imaging of living cells and tissues with bioorthogonal cycling of fluorescent probes. Nat Biotechnol. 2022;40(11):1654-1662 - PMID: 35654978 - PMCID: PMC9669087 - DOI: 10.1038/s41587-022-01339-6

  • Poller WC, Downey J, Mooslechner AA, Khan N, Li L, Chan CT, McAlpine CS, Xu C, Kahles F, He S, Janssen H, Mindur JE, Singh S, Kiss MG, Alonso-Herranz L, Iwamoto Y, Kohler RH, Wong LP, Chetal K, Russo SJ, Sadreyev RI, Weissleder R, Nahrendorf M, Frenette PS, Divangahi M, Swirski FK Brain motor and fear circuits regulate leukocytes during acute stress. Nature. 2022;607(7919):578-584 - PMID: 35636458 - DOI: 10.1038/s41586-022-04890-z

  • Peterson HM, Chin LK, Iwamoto Y, Oh J, Carlson JCT, Lee H, Im H, Weissleder R Integrated Analytical System for Clinical Single-Cell Analysis. Adv Sci (Weinh). 2022;9(20):e2200415 - PMID: 35508767 - PMCID: PMC9284190 - DOI: 10.1002/advs.202200415

  • Grune J, Lewis AJM, Yamazoe M, Hulsmans M, Rohde D, Xiao L, Zhang S, Ott C, Calcagno DM, Zhou Y, Timm K, Shanmuganathan M, Pulous FE, Schloss MJ, Foy BH, Capen D, Vinegoni C, Wojtkiewicz GR, Iwamoto I, Grune T, Brown D, Higgins J, Ferreira VM, Herring N, Channon KM, Neubauer S, Oxford Acute Myocardial Infarction (OxAMI) Study, Sosnovik DE, Milan DJ, Swirski FK, King KR, Aguirre AD, Ellinor PT, Nahrendorf M Neutrophils incite and macrophages avert electrical storm after myocardial infarction. Nat Cardiovasc Res. 2022;1(7):649-664 - PMID: 36034743 - PMCID: PMC9410341 - DOI: 10.1038/s44161-022-00094-w

  • More publications ...

News

2015-06-24:

Recent CSB work has been published on BPoD – Biomedical Picture of the Day.

2012-12-11:

"Imaging Early MS" - An Interview with John Chen, M.D., Ph.D. by Dana Foundation (pdf)

2012-09-10:

Dont forget to register for the upcoming Harvard CME course on Molecular Imaging. The course is being chaired by Drs. Frangioni and Weissleder and features over 30 invited speakers covering all topics of molecular imaging. More information can be found here.

2012-04-13:

"Magnetic Nanoparticles Predict Diabetes Onset" - HMS Focus highlights describes developed at CSB a magnetic nanoparticle-based MRI technique for predicting whether and when subjects with a genetic predisposition for diabetes will develop the disease. (pdf)