Charles Lin

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Charles Lin's Lab

Approach and Findings

The main research focus of our group is to develop minimally invasive optical techniques for in vivo imaging and monitoring of cells and tissues as well as therapeutic applications of lasers. The diagnostic techniques will help to answer important biological questions, such as:

  • In-vivo monitoring of cell trafficking in circulation
  • Imaging of vasculature and microenvironment in tissue
  • Interaction of cells with microenvironment

The therapeutic techniques allow us to target cellular and subcellular structures by means of selective absorption of endogenous or exogenous chromophores. Selective targeting may be helpful for treating various pathologies, such as retinal diseases or destruction of tumors, without causing adverse side effects to healthy tissue.

Recent Publications (more...)

Yu VW, Yusuf RZ, Oki T, Wu J, Saez B, Wang X, Cook C, Baryawno N, Ziller MJ, Lee E, Gu H, Meissner A, Lin CP, Kharchenko PV, Scadden DT
Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells.
Cell. 2016;167(5):1310-1322.e17 - PMID: 27863245
Ito K, Turcotte R, Cui J, Zimmerman SE, Pinho S, Mizoguchi T, Arai F, Runnels JM, Alt C, Teruya-Feldstein J, Mar JC, Singh R, Suda T, Lin CP, Frenette PS, Ito K
Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance.
Science. 2016;:ePub - PMID: 27738012
Silberstein L, Goncalves KA, Kharchenko PV, Turcotte R, Kfoury Y, Mercier F, Baryawno N, Severe N, Bachand J, Spencer JA, Papazian A, Lee D, Chitteti BR, Srour EF, Hoggatt J, Tate T, Lo Celso C, Ono N, Nutt S, Heino J, Sipilä K, Shioda T, Osawa M, Lin CP, Hu GF, Scadden DT
Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators.
Cell Stem Cell. 2016;19(4):530-543 - PMID: 27524439
Yang Z, Concannon J, Ng KS, Seyb K, Mortensen LJ, Ranganath S, Gu F, Levy O, Tong Z, Martyn K, Zhao W, Lin CP, Glicksman MA, Karp JM
Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulation.
Sci Rep. 2016;6:30263 - PMID: 27457881 - PMCID: PMC4960598