Charles Lin

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Charles Lin's Lab

Approach and Findings

The main research focus of our group is to develop minimally invasive optical techniques for in vivo imaging and monitoring of cells and tissues as well as therapeutic applications of lasers. The diagnostic techniques will help to answer important biological questions, such as:

  • In-vivo monitoring of cell trafficking in circulation
  • Imaging of vasculature and microenvironment in tissue
  • Interaction of cells with microenvironment

The therapeutic techniques allow us to target cellular and subcellular structures by means of selective absorption of endogenous or exogenous chromophores. Selective targeting may be helpful for treating various pathologies, such as retinal diseases or destruction of tumors, without causing adverse side effects to healthy tissue.

Recent Publications (more...)

Shao L, Chang J, Feng W, Wang X, Williamson EA, Li Y, Schajnovitz A, Scadden D, Mortensen LJ, Lin CP, Li L, Paulson A, Downing J, Zhou D, Hromas RA
The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow.
Nat Commun. 2018;9(1):2377 - PMID: 29915352 - PMCID: PMC6006146 - DOI: 10.1038/s41467-018-04716-5
Park CO, Fu X, Jiang X, Pan Y, Teague JE, Collins N, Tian T, O'Malley JT, Emerson RO, Kim JH, Jung Y, Watanabe R, Fuhlbrigge RC, Carbone FR, Gebhardt T, Clark RA, Lin CP, Kupper TS
Staged development of long lived TCRαβ Th17 resident memory T cell population to Candida albicans after skin infection.
J Allergy Clin Immunol. 2017;142(2):647-662 - PMID: 29128674 - PMCID: PMC5943196 - DOI: 10.1016/j.jaci.2017.09.042
Charan K, Li B, Wang M, Lin CP, Xu C
Fiber-based tunable repetition rate source for deep tissue two-photon fluorescence microscopy.
Biomed Opt Express. 2018;9(5):2304-2311 - PMID: 29760989 - PMCID: PMC5946790 - DOI: 10.1364/BOE.9.002304