Charles Lin

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Charles Lin's Lab

Approach and Findings

The main research focus of our group is to develop minimally invasive optical techniques for in vivo imaging and monitoring of cells and tissues as well as therapeutic applications of lasers. The diagnostic techniques will help to answer important biological questions, such as:

  • In-vivo monitoring of cell trafficking in circulation
  • Imaging of vasculature and microenvironment in tissue
  • Interaction of cells with microenvironment

The therapeutic techniques allow us to target cellular and subcellular structures by means of selective absorption of endogenous or exogenous chromophores. Selective targeting may be helpful for treating various pathologies, such as retinal diseases or destruction of tumors, without causing adverse side effects to healthy tissue.

Recent Publications (more...)

Lee SK, Mortensen LJ, Lin CP, Tung CH
An authentic imaging probe to track cell fate from beginning to end.
Nat Commun. 2014;5:5216 - PMID: 25323442
Saez B, Ferraro F, Yusuf RZ, Cook CM, Yu VW, Pardo-Saganta A, Sykes SM, Palchaudhuri R, Schajnovitz A, Lotinun S, Lymperi S, Mendez-Ferrer S, Del Toro R, Day R, Vasic R, Acharya SS, Baron R, Lin CP, Yamaguchi Y, Wagers AJ, Scadden DT
Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning.
Blood. 2014;124(19):2937-47 - PMID: 25202142 - PMCID: PMC4224192
Aceto N, Bardia A, Miyamoto DT, Donaldson MC, Wittner BS, Spencer JA, Yu M, Pely A, Engstrom A, Zhu H, Brannigan BW, Kapur R, Stott SL, Shioda T, Ramaswamy S, Ting DT, Lin CP, Toner M, Haber DA, Maheswaran S
Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis.
Cell. 2014;158(5):1110-22 - PMID: 25171411 - PMCID: PMC4149753
Levy O, Mortensen LJ, Boquet G, Tong Z, Perrault C, Benhamou B, Zhang J, Stratton T, Han E, Safaee H, Musabeyezu J, Yang Z, Multon MC, Rothblatt J, Deleuze JF, Lin CP, Karp JM
A Small-Molecule Screen for Enhanced Homing of Systemically Infused Cells.
Cell Rep. 2015;10(8):1261-1268 - PMID: 25732817