Weissleder, Ralph, MD, PhD

Thrall Professor of Radiology
Professor of Systems Biology
Director, Center for Systems Biology

Phone: 617-726-8226
Email: rweissleder@mgh.harvard.edu
Lab: Weissleder, Ralph

Dr. Weissleder has been the Director of CSB at Massachusetts General Hospital (MGH) since its inception in 2007. He is the Thrall Professor of Radiology and Professor of Systems Biology at Harvard Medical School, and Attending Clinician in Interventional Radiology at MGH. Dr. Weissleder is also a member of the Department of Systems Biology at HMS and the Harvard Cancer Center. He is also a member of MGH’s Executive Committee on Research (ECOR) and participates in several other Institutional Committees.

The Weissleder group develops molecular technologies for noninvasive imaging of cellular function, and uses these technologies to study basic human biology and create next generation diagnostics and therapeutics. Many important biological processes occur deep inside our body. Their study requires new technologies to understand function at the single cell level. To develop such technologies, he pursues fundamental advances in chemistry, molecular engineering, bioengineering and modeling. His work also takes advantage of imaging tissues and cells obtained by minimally invasive image guided interventions. His primary interests are in cancer and in inflammation. His work on imaging, nanomaterials and miniaturized sensing technologies has led to a number of new technologies and advanced clinical trials. He is a cofounder of T2Biosystems and Lumicell. Dr. Weissleder is currently the principal investigator of several National Institute of Health grants and consortia. He has published over 940 publications (h-index >185) in peer reviewed journals and has authored several textbooks. He is one of the top 100 ranking scientists in the world according a world ranking list (PLOS Biology, August 12, 2019)

He is a member of the National Academy of Medicine, the American Academy of Arts and Sciences, the National Academy of Inventors and the German Academy of Sciences (Leopoldina). His work has been honored with numerous awards including the J. Taylor International Prize in Medicine, the Millenium Pharmaceuticals Innovator Award, the AUR Memorial Award, the ARRS President’s Award, The Society for Molecular Imaging Lifetime Achievement Award, the Academy of Molecular Imaging 2006 Distinguished Basic Scientist Award, the 2008 RSNA Outstanding Researcher Award and gold medalist of the ESR. In 2014 Dr. Weissleder was named by Thomson Reuters as one of the “The World’s Most Influential Scientific Minds”.

Publications

  • Nahrendorf M, Hoyer FF, Meerwaldt AE, van Leent MMT, Senders ML, Calcagno C, Robson PM, Soultanidis G, Pérez-Medina C, Teunissen AJP, Toner YC, Ishikawa K, Fish K, Sakurai K, van Leeuwen EM, Klein ED, Sofias AM, Reiner T, Rohde D, Aguirre AD, Wojtkiewicz G, Schmidt S, Iwamoto Y, Izquierdo-Garcia D, Caravan P, Swirski FK, Weissleder R, Mulder WJM Imaging Cardiovascular and Lung Macrophages With the Positron Emission Tomography Sensor <sup>64</sup>Cu-Macrin in Mice, Rabbits, and Pigs. Circ Cardiovasc Imaging. 2020;13(10):e010586 - PMID: 33076700 - DOI: 10.1161/CIRCIMAGING.120.010586

  • Pfirschke C, Engblom C, Gungabeesoon J, Lin Y, Rickelt S, Zilionis R, Messemaker M, Siwicki M, Gerhard GM, Kohl A, Meylan E, Weissleder R, Klein AM, Pittet MJ Tumor-Promoting Ly-6G<sup>+</sup> SiglecF<sup>high</sup> Cells Are Mature and Long-Lived Neutrophils. Cell Rep. 2020;32(12):108164 - PMID: 32966785 - PMCID: PMC7508173 - DOI: 10.1016/j.celrep.2020.108164

  • Wang SJ, Li R, Ng TSC, Luthria G, Oudin MJ, Prytyskach M, Kohler RH, Weissleder R, Lauffenburger DA, Miller MA Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy. Sci Adv. 2020;6(21):ePub - PMID: 32937338 - PMCID: PMC7244320 - DOI: 10.1126/sciadv.aaz8521

  • Pai SI, Faquin WC, Sadow PM, Pittet MJ, Weissleder R New Technology on the Horizon: Fast Analytical Screening Technique FNA (FAST-FNA) Enables Rapid, Multiplex Biomarker Analysis in Head and Neck Cancers. Cancer Cytopathol. 2020;:ePub - PMID: 32841527 - DOI: 10.1002/cncy.22305

  • Fumene Feruglio P, Vinegoni C, Weissleder R Extended dynamic range imaging for noise mitigation in fluorescence anisotropy imaging. J Biomed Opt. 2020;25(8):ePub - PMID: 32820624 - PMCID: PMC7439791 - DOI: 10.1117/1.JBO.25.8.086003

  • Min J, Son T, Hong JS, Cheah PS Wegemann A, Murlidharan K, Weissleder R, Lee H, Im H Plasmon-Enhanced Biosensing for Multiplexed Profiling of Extracellular Vesicles. Adv Biosyst. 2020;2020:2000003 - PMID: 32815321 - DOI: 10.1002/adbi.202000003

  • Bachar Issa TH, Vinegoni C, Shaw A, Fumene Feruglio P, Weissleder R, Uminsky D Video-Rate Acquisition Fluorescence Microscopy via Generative Adversarial Networks. EasyChair. 2020;:ePub

  • Min J*, Chin LK*, Oh J, Landeros C, Vinegoni C, Lee J, Lee SJ, Park JY, Liu AQ, Castro CM, Lee H, Im H, Weissleder R CytoPAN—Portable cellular analyses for rapid point-of-care cancer diagnosis. Sci Transl Med. 2020;12:eaaz9746 - PMID: 32759277 - DOI: 10.1126/scitranslmed.aaz9746

  • Kilic T, Weissleder R, Lee H Molecular and immunological diagnostic tests of COVID-19 – current status and challenges. iScience. 2020;23(8):101406 - PMID: 32771976 - PMCID: PMC7381402 - DOI: 10.1016/j.isci.2020.101406

  • Koch PD, Pittet MJ, Weissleder R The chemical biology of IL-12 production via the non-canonical NFkB pathway. RSC Chemical Biology. 2020;1:166-176 - DOI: 10.1039/d0cb00022a

  • Luthria G, Li R, Wang S, Prytyskach M, Kohler RH, Lauffenburger DA, Mitchison TJ, Weissleder R, Miller MA In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells. Nat Commun. 2020;11:3521 - PMID: 32665556 - PMCID: PMC7360550 - DOI: 10.1038/s41467-020-17147-y

  • Weissleder R, Lee H, Ko J, Pittet MJ COVID-19 diagnostics in context. Sci Transl Med. 2020;12(546):eabc1931 - PMID: 32493791 - DOI: 10.1126/scitranslmed.abc1931

  • Ferguson S, Weissleder R Modeling EV Kinetics for Use in Early Cancer Detection. Adv Biosyst. 2020;:e1900305 - PMID: 32394646 - DOI: 10.1002/adbi.201900305

  • Van Deun J, Jo A, Li H, Lin HY, Weissleder R, Im H, Lee H Integrated Dual-Mode Chromatography to Enrich Extracellular Vesicles from Plasma. Adv Biosyst. 2020;:e1900310 - PMID: 32351054 - DOI: 10.1002/adbi.201900310

  • Wang Y, Cao T, Ko J, Shen Y, Zong W, Sheng K, Cao W, Sun S, Cai L, Zhou YL, Zhang XX, Zong C, Weissleder R, Weitz D Dissolvable Polyacrylamide Beads for High-Throughput Droplet DNA Barcoding. Adv Sci. 2020;7(8):1903463 - PMID: 32328429 - PMCID: PMC7175265 - DOI: 10.1002/advs.201903463

  • Marquard AN, Carlson JCT, Weissleder R Expanding the scope of antibody rebridging with new pyridazinedione-TCO constructs. Bioconjug Chem. 2020;31(6):1616-1623 - PMID: 32286045 - DOI: 10.1021/acs.bioconjchem.0c00155

  • Li R, Ng TSC, Garlin MA, Weissleder R*, Miller MA* Understanding the In Vivo Fate of Advanced Materials by Imaging. Adv Funct Mater. 2020;:1910369 - DOI: 10.1002/adfm.201910369

  • Vinegoni C, Fumene Feruglio P, Courties G, Schmidt S, Hulsmans M, Lee S, Wang R, Sosnovik D, Nahrendorf M, Weissleder R Fluorescence microscopy tensor imaging representations for large-scale dataset analysis. Sci Rep. 2020;10(1):5632 - PMID: 32221334 - PMCID: PMC7101442 - DOI: 10.1038/s41598-020-62233-2

  • Weissleder R, Pittet MJ The expanding landscape of inflammatory cells affecting cancer therapy. Nat Biomed Eng. 2020;4(5):489-498 - PMID: 32203281 - PMCID: PMC7405944 - DOI: 10.1038/s41551-020-0524-y

  • Ko J, Wang Y, Carlson JCT, Marquard A, Gungabeesoon J, Charest A, Weitz D, Pittet MJ, Weissleder R Single Extracellular Vesicle Protein Analysis Using Immuno- Droplet Digital Polymerase Chain Reaction Amplification. Adv Biosyst. 2020;:ePub - DOI: 10.1002/adbi.201900307

  • Figueiredo JL, Santa-Cruz F, Lima-Filho JL, Hilgendorf I, Aikawa M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK, Robbins CS A durable murine model of spleen transplantation with arterial and venous anastomoses. Sci Rep. 2020;10(1):3979 - PMID: 32132617 - PMCID: PMC7055260 - DOI: 10.1038/s41598-020-60983-7

  • Weissleder R, Lee H Automated molecular-image cytometry and analysis in modern oncology. Nature Review Materials. 2020;:ePub - DOI: 10.1038/s41578-020-0180-6

  • Cremer S, Schloss MJ, Vinegoni C, Foy BH, Zhang S, Rohde D, Hulsmans M, Fumene Feruglio P, Schmidt S, Wojtkiewicz G, Higgins JM, Weissleder R, Swirski FK, Nahrendorf M Diminished Reactive Hematopoiesis and Cardiac Inflammation in a Mouse Model of Recurrent Myocardial Infarction. J Am Coll Cardiol. 2020;75(8):901-915 - PMID: 32130926 - PMCID: PMC7254576 - DOI: 10.1016/j.jacc.2019.12.056

  • Herrmann K, Schwaiger M, Lewis JS, Solomon SB, McNeil BJ, Baumann M, Gambhir SS, Hricak H, Weissleder R Radiotheranostics: a roadmap for future development. Lancet Oncol. 2020;21(3):e146–56 - PMID: 32135118 - PMCID: PMC7367151 - DOI: 10.1016/S1470-2045(19)30821-6 - Cover

  • Ko J, Oh J, Ahmed MS, Carlson JCT, Weissleder R Ultra-fast cycling for multiplexed cellular fluorescence imaging. Angew Chem Int Ed Engl. 2020;59(17):6839-6846 - PMID: 32004403 - DOI: 10.1002/anie.201915153

  • Raisbeck JC, Allen M, Weissleder R, Im H, Lee H Evolution Strategies Converges to Finite Differences. arXiv. 2020;:ePub

  • Calcagno DM, Ng RP, Toomu A, Zhang C, Huang K, Aguirre AD, Weissleder R, Daniels LB, Fu Z, King KR Type I interferon responses to ischemic injury begin in the bone marrow of mice and humans and depend on Tet2, Nrf2, and Irf3. Sci Immunol. 2020;:ePub - PMID: 32978242 - DOI: 10.1126/sciimmunol.aaz1974

  • Koch PD, Rodell CB, Kohler RH, Pittet MJ, Weissleder R Myeloid Cell-Targeted Nanocarriers Efficiently Inhibit Cellular Inhibitor of Apoptosis for Cancer Immunotherapy. Cell Chem Biol. 2020;27(1):94-104.e5 - PMID: 31902676 - PMCID: PMC7422681 - DOI: 10.1016/j.chembiol.2019.12.007

  • Koch PD, Ahmed MS, Kohler RH, Li R, Weissleder R Imaging of Tie2 with a fluorescently labeled small molecule affinity ligand. ACS Chem Biol. 2020;15(1):151-157 - PMID: 31809013 - DOI: 10.1021/acschembio.9b00724

  • Li R, Attari A, Prytyskach M, Garlin MA, Weissleder R, Miller MA Single‐Cell Intravital Microscopy of Trastuzumab Quantifies Heterogeneous in vivo Kinetics. Cytometry A. 2020;97(5):528-539 - PMID: 31423731 - PMCID: PMC7028488 - DOI: 10.1002/cyto.a.23872

  • Harisinghani MG, O’Shea A, Weissleder R Advances in clinical MRI technology. Sci Transl Med. 2019;11 (523):eaba2591 - PMID: 31852796 - DOI: 10.1126/scitranslmed.aba2591

  • Yekula A, Minciacchi VR, Morello M, Shao H, Park Y, Zhang X, Muralidharan K, Freeman MR, Weissleder R, Lee H, Carter B, Breakefield XO, Di Vizio D, Balaj L Large and small extracellular vesicles released by glioma cells in vitro and in vivo. J Extracell Vesicles. 2019;9(1):1689784 - PMID: 31839905 - PMCID: PMC6896449 - DOI: 10.1080/20013078.2019.1689784

  • Liao HW, Garris C, Pfirschke C, Rickelt S, Arlauckas S, Siwicki M, Kohler RH, Weissleder R, Sundvold-Gjerstad V, Sveinbjørnsson B, Rekdal Ø, Pittet MJ LTX-315 sequentially promotes lymphocyte-independent and lymphocyte-dependent antitumor effects. Cell Stress. 2019;3(11):348-360 - PMID: 31799501 - PMCID: PMC6859426 - DOI: 10.15698/cst2019.11.204

  • Chin LY, Carroll C, Raigani S, Detelich DM, Tessier SN, Wojtkiewicz GR, Schmidt SP, Weissleder R, Yeh H, Uygun K, Parekkadan B Ex vivo perfusion-based engraftment of genetically engineered cell sensors into transplantable organs. PLoS ONE. 2019;14(12):e0225222 - PMID: 31790444 - PMCID: PMC6886851 - DOI: 10.1371/journal.pone.0225222

  • Zaborowski MP, Cheah PS, Zhang X, Bushko I, Lee K, Sammarco A, Zappulli V, Maas SLN, Allen RM, Rumde P, György B, Aufiero M, Schweiger MW, Lai CP, Weissleder R, Lee H, Vickers KC, Tannous BA, Breakefield XO Membrane-bound Gaussia luciferase as a tool to track shedding of membrane proteins from the surface of extracellular vesicles. Sci Rep. 2019;9(1):17387 - PMID: 31758005 - PMCID: PMC6874653 - DOI: 10.1038/s41598-019-53554-y

  • Hoyer FF*, Naxerova K*, Schloss MJ, Hulsmans M, Nair AV, Dutta P, Calcagno DM, Herisson F, Anzai A, Sun Y, Wojtkiewicz G, Rohde D, Frodermann V, Vandoorne K, Courties G, Iwamoto Y, Garris CS, Williams DL, Breton S, Brown D, Whalen M, Libby P, Pittet MJ, King KR, Weissleder R, Swirski FK, Nahrendorf M Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge. Immunity. 2019;51(5):899-914.e7 - PMID: 31732166 - PMCID: PMC6892583 - DOI: 10.1016/j.immuni.2019.10.010

  • Rodell CB, Koch PD, Weissleder R Screening for new macrophage therapeutics. Theranostics. 2019;9(25):7714-7729 - PMID: 31695796 - PMCID: PMC6831478 - DOI: 10.7150/thno.34421

  • Rodell CB, Ahmed MS, Garris CS, Pittet MJ, Weissleder R Development of adamantane-conjugated TLR7/8 agonists for supramolecular delivery and cancer immunotherapy. Theranostics. 2019;9(26):8426-8436 - PMID: 31879528 - PMCID: PMC6924259 - DOI: 10.7150/thno.35434

  • Ng TSC, Garlin MA, Weissleder R, Miller MA Understanding the EPR effect through image-guided systems pharmacology. Theranostics. 2019;:ePub

  • Pathania D, Landeros C, Rohrer L, D’Agostino V, Hong S, Degani I, Avila-Wallace M, Pivovarov M, Randall T, Weissleder R, Lee H, Im H, Castro CM Point-of-care cervical cancer screening using deep learning-based microholography. Theranostics. 2019;9(26):8438-8447 - PMID: 31879529 - PMCID: PMC6924258 - DOI: 10.7150/thno.37187

  • Park SG, Xiao X, Min J, Mun CW, Jung HS, Giannini V, Weissleder R, Maier SA, Im H, Kim DH Self‐Assembly of Nanoparticle‐Spiked Pillar Arrays for Plasmonic Biosensing. Adv Funct Mater. 2019;29(43):1904257 - DOI: 10.1002/adfm.201904257

  • Huang CH, Park YI, Lin HY, Pathania D, Park KS, Avila-Wallace M, Castro CM, Weissleder R, Lee H Compact and Filter-Free Luminescence Biosensor for Mobile <i>In-Vitro</i> Diagnoses. ACS Nano. 2019;13(10):11698-11706 - PMID: 31461265 - PMCID: PMC7307311 - DOI: 10.1021/acsnano.9b05634

  • Marquard AN, Carlson JCT, Weissleder R Glass Chemistry to Analyze Human Cells under Adverse Conditions. ACS Omega. 2019;4:11515−11521 - PMID: 31460257 - PMCID: PMC6682085 - DOI: 10.1021/acsomega.9b01036

  • Gyuris A, Navarrete-Perea J, Jo A, Cristea S, Zhou S, Fraser K, Wei Z, Krichevsky AM, Weissleder R, Lee H, Gygi SP, Charest A Physical and Molecular Landscapes of Mouse Glioma Extracellular Vesicles Define Heterogeneity. Cell Rep. 2019;27(13):3972-3987.e6 - PMID: 31242427 - PMCID: PMC6604862 - DOI: 10.1016/j.celrep.2019.05.089

  • Florian S, Iwamoto Y, Coughlin M, Weissleder R, Mitchison TJ A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor. Proc Natl Acad Sci U S A. 2019;116(23):11444-11453 - PMID: 31101720 - PMCID: PMC6561274 - DOI: 10.1073/pnas.1702372116

  • Zaborowski MP, Lee K, Na YJ, Sammarco A, Zhang X, Iwanicki M, Cheah PS, Lin HY, Zinter M, Chou CY, Fulci G, Tannous BA, Lai CP, Birrer MJ, Weissleder R, Lee H, Breakefield XO Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles. Cell Rep. 2019;27(1):255-268.e6 - PMID: 30943406 - PMCID: PMC6528836 - DOI: 10.1016/j.celrep.2019.03.003

  • Erel-Akbaba G, Carvalho LA, Tian T, Zinter M, Akbaba H, Obeid PJ, Chiocca EA, Weissleder R, Kantarci AG, Tannous BA Radiation-Induced Targeted Nanoparticle- Based Gene Delivery for Brain Tumor Therapy. ACS Nano. 2019;13(4):4028-4040 - PMID: 30916923 - PMCID: PMC7104714 - DOI: 10.1021/acsnano.8b08177

  • He S*, Kahles F*, Rattik S*, Nairz M, McAlpine CS, Anzai A, Selgrade D, Fenn AM, Chan CT, Mindur JE, Valet C, Poller WC, Halle L, Rotllan N, Iwamoto Y, Wojtkiewicz GR, Weissleder R, Libby P, Fernández-Hernando C, Drucker DJ, Nahrendorf M, Swirski FK Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease. Nature. 2019;566(7742):115-119 - PMID: 30700910 - PMCID: PMC6367023 - DOI: 10.1038/s41586-018-0849-9

  • Bae SH, Jo A, Park JH, Lim CW, Choi Y, Oh J, Park JM, Kong T, Weissleder R, Lee H, Moon J Bioassay for monitoring the anti-aging effect of cord blood treatment. Theranostics. 2019;9(1):1-10 - PMID: 30662549 - PMCID: PMC6332798 - DOI: 10.7150/thno.30422

  • Ahmed MS, Rodell CB, Hulsmans M, Kohler RH, Aguirre A, Nahrendorf M, Weissleder R A Supramolecular Nanocarrier for Delivery of Amiodarone Anti-Arrhythmic Therapy to the Heart. Bioconjug Chem. 2019;30(3):733-740 - PMID: 30615425 - PMCID: PMC6483069 - DOI: 10.1021/acs.bioconjchem.8b00882

  • Fraser K, Jo A, Giedt J, Vinegoni C, Yang KS, Peruzzi P, Chiocca EA, Breakefield XO, Lee H, Weissleder R Characterization of single microvesicles in plasma from glioblastoma patients. Neuro Oncol. 2019;21(5):606-615 - PMID: 30561734 - PMCID: PMC6502493 - DOI: 10.1093/neuonc/noy187

  • Vinegoni C, Feruglio PF, Weissleder R High dynamic range fluorescence imaging. IEEE J Sel Top Quantum Electron. 2018;25(1):ePub - PMID: 31598059 - PMCID: PMC6785194 - DOI: 10.1109/JSTQE.2018.2881608

  • Vinegoni C, Feruglio PF, Weissleder R High dynamic range fluorescence imaging. IEEE J Sel Top Quantum Electron. 2018;25(1):ePub - PMID: 31598059 - PMCID: PMC6785194 - DOI: 10.1109/JSTQE.2018.2881608

  • Miller MA, Mikula H, Luthria G, Li R, Kronister S, Prytyskach M, Kohler RH, Mitchison T, Weissleder R Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation. ACS Nano. 2018;12(12):12814-12826 - PMID: 30550257 - PMCID: PMC6307086 - DOI: 10.1021/acsnano.8b07954

  • Kim HY, Li R, Ng TSC, Courties G, Rodell CB, Prytyskach M, Kohler RH, Pittet M, Nahrendorf M, Weissleder R, Miller MA Quantitative Imaging of Tumor Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin. ACS Nano. 2018;12(12):12015-12029 - PMID: 30508377 - PMCID: PMC6482841 - DOI: 10.1021/acsnano.8b04338

  • Garris CS*, Arlauckas SP*, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12. Immunity. 2018;49:1-14 - PMID: 30552023 - PMCID: PMC6301092 - DOI: 10.1016/j.immuni.2018.09.024

  • Kim SJ*, Wang C*, Zhao B, Im H, Min J, Choi HJ, Tadros J, Choi NR, Castro CM, Weissleder R, Lee H, Lee K Deep transfer learning-based hologram classification for molecular diagnostics. Sci Rep. 2018;8(1):17003 - PMID: 30451953 - PMCID: PMC6242900 - DOI: 10.1038/s41598-018-35274-x

  • Pineda JJ, Miller MA, Song Y, Kuhn H, Mikula H, Tallapragada N, Weissleder R, Mitchison TJ Site occupancy calibration of taxane pharmacology in live cells and tissues. Proc Natl Acad Sci U S A. 2018;115(48):E11406-E11414 - PMID: 30429313 - PMCID: PMC6275538 - DOI: 10.1073/pnas.1800047115

  • Arlauckas SP*, Garren SB*, Garris CS, Kohler RH, Oh J, Pittet MJ, Weissleder R Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages. Theranostics. 2018;8(21):5842-5854 - PMID: 30613266 - PMCID: PMC6299430 - DOI: 10.7150/thno.26888

  • Oh J, Magnuson A, Benoist C, Pittet MJ, Weissleder R Age-related tumor growth in mice is related to integrin α 4 in CD8+ T cells. JCI Insight. 2018;3(21):ePub - PMID: 30385729 - PMCID: PMC6238736 - DOI: 10.1172/jci.insight.122961

  • Giedt RJ, Pathania D, Carlson JCT, McFarland PJ, Del Castillo AF, Juric D, Weissleder R Single-cell barcode analysis provides a rapid readout of cellular signaling pathways in clinical specimens. Nat Commun. 2018;9(1):4550 - PMID: 30382095 - PMCID: PMC6208406 - DOI: 10.1038/s41467-018-07002-6

  • Magnuson AM, Kiner E, Ergun A, Park JS, Asinovski N, Ortiz-Lopez A, Kilcoyne A, Paoluzzi-Tomada E, Weissleder R, Mathis D, Benoist C Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types. Proc Natl Acad Sci U S A. 2018;115(45):E10672-E10681 - PMID: 30348759 - PMCID: PMC6233093 - DOI: 10.1073/pnas.1810580115

  • Hulsmans M, Aguirre AD, Bonner M, Bapat A, Cremer S, Iwamoto Y, King KR, Swirski FK, Milan DJ, Weissleder R, Nahrendorf M Miniaturized, Programmable Pacemaker for Long-Term Studies in the Mouse. Circ Res. 2018;123(11):1208-1219 - PMID: 30571465 - PMCID: PMC6309285 - DOI: 10.1161/CIRCRESAHA.118.313429

  • Pittet MJ, Garris CS, Arlauckas SP, Weissleder R Recording the wild lives of immune cells. Sci Immunol. 2018;3(27):ePub - PMID: 30194240 - PMCID: PMC6771424 - DOI: 10.1126/sciimmunol.aaq0491

  • Aganj I, Harisinghani MG, Weissleder R, Fischl B Unsupervised medical image segmentation based on the local center of mass. Sci Rep. 2018;8:13012 - PMID: 30158534 - PMCID: PMC6115387 - DOI: 10.1038/s41598-018-31333-5

  • Herisson F, Frodermann V, Courties G, Rohde D, Sun Y, Vandoorne K, Wojtkiewicz GR, Santos Masson G, Vinegoni C, Kim J, Kim DE, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration. Nat Neurosci. 2018;21(9):1209-1217 - PMID: 30150661 - PMCID: PMC6148759 - DOI: 10.1038/s41593-018-0213-2

  • Min J, Im H, Allen M, McFarland PJ, Degani I, Yu H, Normandin E, Pathania D, Patel J, Castro CM, Weissleder R, Lee H Computational Optics Enables Breast Cancer Profiling in Point-Of-Care Settings. ACS Nano. 2018;12(9):9081-9090 - PMID: 30113824 - PMCID: PMC6519708 - DOI: 10.1021/acsnano.8b03029

  • Im H, Pathania D, McFarland PJ, Sohani AR, Degani I, Allen M, Coble M, Kilcoyne A, Hong S, Rohrer L, Abramson JS, Dryden-Peterson S, Fexon L, Pivovarov M, Chabner B, Lee H, Castro CM, Weissleder R Design and clinical validation of a point-of-care device for the diagnosis of lymphoma via contrast- enhanced microholography and machine learning. Nat Biomed Eng. 2018;2(9):666-674 - PMID: 30555750 - PMCID: PMC6291220 - DOI: 10.1038/s41551-018-0265-3

  • Vandoorne K, Rohde D, Kim HY, Courties G, Wojtkiewicz GR, Honold L, Hoyer FF, Frodermann V, Nayar R, Herisson FE, Jung Y, Désogère P, Vinegoni C, Caravan P, Weissleder R, Sosnovik DE, Lin CP, Swirski FK, Nahrendorf M Imaging the Vascular Bone Marrow Niche During Inflammatory Stress. Circ Res. 2018;123(4):415-427 - PMID: 29980569 - PMCID: PMC6202141 - DOI: 10.1161/CIRCRESAHA.118.313302

  • Sahin A, Sanchez C, Bullain S, Waterman P, Weissleder R, Carter BS Development of third generation anti-EGFRvIII chimeric T cells and EGFRvIII-expressing artificial antigen presenting cells for adoptive cell therapy for glioma. PLoS ONE. 2018;13(7):e0199414 - PMID: 29975720 - PMCID: PMC6033533 - DOI: 10.1371/journal.pone.0199414

  • Schoenberg SO, Attenberger UI, Solomon SB, Weissleder R Developing a Roadmap for Interventional Oncology. Oncologist. 2018;23(10):1162-1170 - PMID: 29959284 - PMCID: PMC6263130 - DOI: 10.1634/theoncologist.2017-0654

  • Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, Kohler RH, Pittet MJ, Weissleder R TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy. Nature Biomedical Engineering. 2018;2:578-588 - PMID: 30345161 - PMCID: PMC6192054 - DOI: 10.1038/s41551-018-0236-8

  • Ingram JR, Blomberg OS, Rashidian M, Ali L, Garforth S, Fedorov E, Fedorov AA, Bonanno JB, Le Gall C, Crowley S, Espinosa C, Biary T, Keliher EJ, Weissleder R, Almo SC, Dougan SK, Ploegh HL, Dougan M Anti-CTLA-4 therapy requires an Fc domain for efficacy. Proc Natl Acad Sci U S A. 2018;115(15):3912-3917 - PMID: 29581255 - PMCID: PMC5899492 - DOI: 10.1073/pnas.1801524115

  • Ricklefs FL, Alayo Q, Krenzlin H, Mahmoud AB, Speranza MC, Nakashima H, Hayes JL, Lee K, Balaj L, Passaro C, Rooj AK, Krasemann S, Carter BS, Chen CC, Steed T, Treiber J, Rodig S, Yang K, Nakano I, Lee H, Weissleder R, Breakefield XO, Godlewski J, Westphal M, Lamszus K, Freeman GJ, Bronisz A, Lawler SE, Chiocca EA Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles. Sci Adv. 2018;4(3):eaar2766 - PMID: 29532035 - PMCID: PMC5842038 - DOI: 10.1126/sciadv.aar2766

  • Min J, Nothing M, Coble B, Zheng H, Park J, Im H, Weber GF, Castro CM, Swirski FK, Weissleder R, Lee H Integrated Biosensor for Rapid and Point-Of-Care Sepsis Diagnosis. ACS Nano. 2018;12(4):3378-3384 - PMID: 29533646 - PMCID: PMC6019292 - DOI: 10.1021/acsnano.7b08965

  • Lin HY, Yang KS, Curley C, Lee H, Welch MW, Wolpin BM, Weissleder R, Im H, Castro C Bead Enhancement of EV Analysis. bioRxiv. 2018;:ePub - DOI: 10.1101/269423

  • Vinegoni C, Feruglio PF, Gryczynski I, Mazitschek R, Weissleder R Fluorescence anisotropy imaging in drug discovery. Adv Drug Deliv Rev. 2018;151-152:262-288 - PMID: 29410158 - PMCID: PMC6072632 - DOI: 10.1016/j.addr.2018.01.019

  • Shao H, Im H, Castro CM, Breakefield X, Weissleder R, Lee H New Technologies for Analysis of Extracellular Vesicles. Chem Rev. 2018;118(4):1917-1950 - PMID: 29384376 - PMCID: PMC6029891 - DOI: 10.1021/acs.chemrev.7b00534

  • Carlson J, Mikula H, Weissleder R Unraveling tetrazine-triggered bioorthogonal elimination enables chemical tools for ultrafast release and universal cleavage. J Am Chem Soc. 2018;140(10):3603-3612 - PMID: 29384666 - PMCID: PMC5857921 - DOI: 10.1021/jacs.7b11217

  • Hulsmans M, Sager HB, Roh JD, Valero-Muñoz M, Houstis NE, Iwamoto Y, Sun Y, Wilson RM, Wojtkiewicz G, Tricot B, Osborne MT, Hung J, Vinegoni C, Naxerova K, Sosnovik DE, Zile MR, Bradshaw AD, Liao R, Tawakol A, Weissleder R, Rosenzweig A, Swirski FK, Sam F, Nahrendorf M Cardiac macrophages promote diastolic dysfunction. J Exp Med. 2018;215(2):423-440 - PMID: 29339450 - PMCID: PMC5789416 - DOI: 10.1084/jem.20171274

  • Lee K, Fraser K, Ghaddar B, Yang K, Kim E, Balaj L, Chiocca A, Breakefield XO, Lee H, Weissleder R Multiplexed Profiling of Single Extracellular Vesicles. ACS Nano. 2018;12(1):494-503 - PMID: 29286635 - PMCID: PMC5898240 - DOI: 10.1021/acsnano.7b07060

  • Park J*, Im H*, Hong S, Castro CM, Weissleder R, Hakho Lee H Analyses of Intravesicular Exosomal Proteins Using a Nano-Plasmonic System. ACS Photonics. 2018;5(2):487-494 - PMID: 29805987 - PMCID: PMC5966285 - DOI: 10.1021/acsphotonics.7b00992

  • Speranza MC, Passaro C, Ricklefs F, Kasai K, Klein SR, Nakashima H, Kaufmann JK, Ahmed AK, Nowicki MO, Obi P, Bronisz A, Aguilar-Cordova E, Aguilar LK, Guzik BW, Breakefield X, Weissleder R, Freeman GJ, Reardon DA, Wen P, Chiocca EA, Lawler SE Preclinical investigation of gene-mediated cytotoxic immunotherapy and checkpoint blockade in glioblastoma. Neuro Oncol. 2018;20(2):225-235 - PMID: 29016938 - PMCID: PMC5777502 - DOI: 10.1093/neuonc/nox139

  • Kakkar A, Traverso G, Farokhzad OC, Weissleder R, Langer R Evolution of macromolecular complexity in drug delivery systems. Nat Rev Chem. 2017;1(8):ePub - PMID: 31286060 - PMCID: PMC6613785 - DOI: 10.1038/s41570-017-0063

  • Kim SJ, Zhao B, Im H, Min J, Choi N, Castro CM, Weissleder R, Lee H, Lee K Deep-learning based hologram classification for molecular diagnostics. bioRxiv. 2017;192559:ePub - DOI: 10.1101/192559

  • Engblom C*, Pfirschke C*, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils. Science. 2017;358:eaal5081 - PMID: 29191879 - PMCID: PMC6343476 - DOI: 10.1126/science.aal5081

  • Miller MA, Kim E, Cuccarese MF, Plotkin AL, Prytyskach M, Kohler RH, Pittet MJ, Weissleder R Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease. Chem Commun. 2017;54(1):42-45 - PMID: 29185561 - PMCID: PMC5736449 - DOI: 10.1039/c7cc07581b

  • Park K, Kim H, Kim S, Lee K, Park S, Song J, Min C, Khanam F, Rashu R, Bhuiyan TR, Ryan ET, Qadri F, Weissleder R, Cheon J, Charles RC, Lee H Nano-Magnetic System For Rapid Diagnosis Of Acute Infection. ACS Nano. 2017;11(11):11425-11432 - PMID: 29121461 - PMCID: PMC6296367 - DOI: 10.1021/acsnano.7b06074

  • King KR, Aguirre AD, Ye YX, Sun Y, Roh JD, Ng Jr RP, Kohler RH, Arlauckas SP, Iwamoto Y, Savol A, Sadreyev RI, Kelly M, Fitzgibbons TP, Fitzgerald KA, Mitchison T, Libby P, Nahrendorf M, Weissleder R IRF3 and type I interferons fuel a fatal response to myocardial infarction. Nature Med. 2017;23(12):1481-1487 - PMID: 29106401 - PMCID: PMC6477926 - DOI: 10.1038/nm.4428

  • Min C, Park J, Mun JK, Lim Y, Min J, Lim JW, Kang DM, Ahn HK, Shin TH, Cheon J, Lee HS, Weissleder R, Castro CM, Lee H Integrated microHall magnetometer to measure the magnetic properties of nanoparticles. Lab Chip. 2017;17(23):4000-4007 - PMID: 29067383 - PMCID: PMC5698130 - DOI: 10.1039/c7lc00934h

  • Frenk NE, Spring L, Muzikansky A, Vadvala HV Gurski JM Jr, Henderson LE, Mino-Kenudson M, Ly A, Bardia A, Finkelstein D, Engelman J, Mueller PR, Juric D, Weissleder R High-Content Biopsies Facilitate Molecular Analyses and Do Not Increase Complication Rates in Patients With Advanced Solid Tumors. JCO Precis Oncol. 2017;1:1-9

  • Park J, Lin HY, Assaker JP, Jeong S, Huang CH, Kurdi A, Lee K, Fraser K, Min C, Eskandari S, Routray S, Tannous BA, Abdi R, Riella L, Chandraker A, Castro CM, Weissleder R, Lee H, Azzi JR Integrated Kidney Exosome Analysis (iKEA) For The Detection Of Kidney Transplant Rejection. ACS Nano. 2017;11(11):11041-11046 - PMID: 29053921 - PMCID: PMC6237084 - DOI: 10.1021/acsnano.7b05083

  • Anzai A, Choi JL, He S, Fenn AM, Nairz M, Rattik S, McAlpine CS, Mindur JE, Chan CT, Iwamoto Y, Tricot B, Wojtkiewicz GR, Weissleder R, Libby P, Nahrendorf M, Stone JR, Becher B, Swirski FK The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes. J Exp Med. 2017;214(11):3293-3310 - PMID: 28978634 - PMCID: PMC5679174 - DOI: 10.1084/jem.20170689

  • Ingram JR, Dougan M, Rashidian M, Knoll M, Keliher EJ, Garrett S, Garforth S, Blomberg OS, Espinosa C, Bhan A, Almo SC, Weissleder R, Lodish H, Dougan SK, Ploegh HL PD-L1 is an activation-independent marker of brown adipocytes. Nat Commun. 2017;8(1):647 - PMID: 28935898 - PMCID: PMC5608754 - DOI: 10.1038/s41467-017-00799-8

  • Mohan JF, Kohler RH, Hill JA, Weissleder R, Mathis D, Benoist C Imaging the emergence and natural progression of spontaneous autoimmune diabetes. Proc Natl Acad Sci U S A. 2017;114(37):E7776-E7785 - PMID: 28839093 - PMCID: PMC5604023 - DOI: 10.1073/pnas.1707381114

  • Miller MA, Weissleder R Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior. Adv Drug Deliv Rev. 2017;113:61-86 - PMID: 27266447 - PMCID: PMC5136524 - DOI: 10.1016/j.addr.2016.05.023

  • Lin HY, Huang CH, Park J, Pathania D, Castro CM, Fasano A, Weissleder R, Lee H Integrated Magneto-Chemical Sensor For On-Site Food Allergen Detection. ACS Nano. 2017;11(10):10062-10069 - PMID: 28792732 - DOI: 10.1021/acsnano.7b04318

  • Im H, Lee K, Weissleder R, Lee H, Castro CM Novel nanosensing technologies for exosome detection and profiling. Lab Chip. 2017;17(17):2892-2898 - PMID: 28745363 - PMCID: PMC5572557 - DOI: 10.1039/c7lc00247e

  • Mamuya FA, Xie D, Lei L, Huang M, Tsuji K, Capen DE, Yang B, Weissleder R, Păunescu TG, Lu HJ Deletion of β-1 integrin in collecting duct principal cells leads to tubular injury and renal medullary fibrosis. Am J Physiol Renal Physiol. 2017;:ajprenal.00038.2017 - PMID: 28701310 - PMCID: PMC5668581 - DOI: 10.1152/ajprenal.00038.2017

  • Miller MA, Askevold B, Mikula H, Kohler RH, Pirovich D, Weissleder R Nano-palladium is a cellular catalyst for in vivo chemistry. Nat Commun. 2017;8:15906 - PMID: 28699627 - PMCID: PMC5510178 - DOI: 10.1038/ncomms15906

  • Miller MA, Arlauckas S, Weissleder R Prediction of Anti-cancer Nanotherapy Efficacy by Imaging. Nanotheranostics. 2017;1(3):296-312 - PMID: 29071194 - PMCID: PMC5646731 - DOI: 10.7150/ntno.20564

  • Vinegoni C, Fumene Feruglio P, Brand C, Lee S, Nibbs AE, Stapleton S, Shah S, Gryczynski I, Reiner T, Mazitschek R, Weissleder R Measurement of drug-target engagement in live cells by two-photon fluorescence anisotropy imaging. Nat Protoc. 2017;12(7):1472-1497 - PMID: 28686582 - PMCID: PMC5928516 - DOI: 10.1038/nprot.2017.043

  • Miller MA, Weissleder R Imaging of anticancer drug action in single cells. Nat Rev Cancer. 2017;17(7):399–414 - PMID: 28642603 - PMCID: PMC7552440 - DOI: 10.1038/nrc.2017.41

  • Jeong S, Eskandari R, Park SM, Alvarez J, Tee SS, Weissleder R, Kharas MG, Lee H, Keshari KR Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer. Sci Adv. 2017;3(6):e1700341 - PMID: 28630930 - PMCID: PMC5473678 - DOI: 10.1126/sciadv.1700341

  • Miller MA, Chandra R, Cuccarese MF, Pfirschke C, Engblom C, Stapleton S, Adhikary U, Kohler RH, Mohan JF, Pittet MJ, Weissleder R Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts. Sci Transl Med. 2017;9(392):eaal0225 - PMID: 28566423 - PMCID: PMC6681815 - DOI: 10.1126/scitranslmed.aal0225

  • Yang KS*, Im H*, Hong S, Pergolini I, Del Castillo AF, Wang R, Clardy S, Huang CH, Pille C, Ferrone S, Yang R, Castro CM, Lee H, Del Castillo CF, Weissleder R Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy. Sci Transl Med. 2017;9(391):eaal3226 - PMID: 28539469 - PMCID: PMC5846089 - DOI: 10.1126/scitranslmed.aal3226

  • Godlewski J, Ferrer-Luna R, Rooj AK, Mineo M, Ricklefs F, Takeda YS, Nowicki MO, Salińska E, Nakano I, Lee H, Weissleder R, Beroukhim R, Chiocca EA, Bronisz A MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer. Stem Cell Reports. 2017;8(6):1497-1505 - PMID: 28528698 - PMCID: PMC5470095 - DOI: 10.1016/j.stemcr.2017.04.024

  • Arlauckas SP*, Garris CS*, Kohler RH, Kitaoka M, Cuccarese MF, Yang KS, Miller MA, Carlson JC, Freeman GJ, Anthony RM, Weissleder R, Pittet MJ In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy. Sci Transl Med. 2017;9(389):eaal3604 - PMID: 28490665 - PMCID: PMC5734617 - DOI: 10.1126/scitranslmed.aal3604

  • Mikula H, Stapleton S, Kohler RH, Vinegoni C, Weissleder R Design and Development of Fluorescent Vemurafenib Analogs for In Vivo Imaging. Theranostics. 2017;7(5):1257-1265 - PMID: 28435463 - PMCID: PMC5399591 - DOI: 10.7150/thno.18238

  • Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M Macrophages Facilitate Electrical Conduction in the Heart. Cell. 2017;169:510-522 - PMID: 28431249 - PMCID: PMC5474950 - DOI: 10.1016/j.cell.2017.03.050

  • Seo KJ, Qiang Y, Bilgin I, Kar S, Vinegoni C, Weissleder R, Fang H Transparent Electrophysiology Microelectrodes and Interconnects from Metal Nanomesh. ACS Nano. 2017;11(4):4365-4372 - PMID: 28391679 - DOI: 10.1021/acsnano.7b01995

  • Lee S, Courties G, Nahrendorf M, Weissleder R, Vinegoni C Motion characterization scheme to minimize motion artifacts in intravital microscopy. J Biomed Opt. 2017;22(3):36005 - PMID: 28253383 - PMCID: PMC5333764 - DOI: 10.1117/1.JBO.22.3.036005

  • Cuccarese MF, Dubach JM, Pfirschke C, Engblom C, Garris C, Miller MA, Pittet MJ, Weissleder R Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging. Nat Commun. 2017;8:14293 - PMID: 28176769 - PMCID: PMC5309815 - DOI: 10.1038/ncomms14293

  • Hong S, Park KS, Weissleder R, Castro CM, Lee H Facile silicification of plastic surface for bioassays. Chem Commun. 2017;53(13):2134-2137 - PMID: 28134385 - PMCID: PMC5327824 - DOI: 10.1039/c6cc09359k

  • Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, Kim HY, Wang C, Chen JW, Swirski FK, Wey HY, Hooker J, Fayad ZA, Mulder WJ, Weissleder R, Nahrendorf M Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease. Nat Commun. 2017;8:14064 - PMID: 28091604 - PMCID: PMC5241815 - DOI: 10.1038/ncomms14064

  • Gee MS, Ghazani AA, Haq R, Wargo JA, Sebas M, Sullivan RJ, Lee H, Weissleder R Point of care assessment of melanoma tumor signaling and metastatic burden from μNMR analysis of tumor fine needle aspirates and peripheral blood. Nanomedicine. 2017;13(3):821-828 - PMID: 27993725 - PMCID: PMC5392428 - DOI: 10.1016/j.nano.2016.12.006

  • Park YI, Kim E, Huang CH, Park KS, Castro CM, Lee H, Weissleder R Facile Coating Strategy to Functionalize Inorganic Nanoparticles for Biosensing. Bioconjug Chem. 2017;28(1):33-37 - PMID: 27792877 - PMCID: PMC5474933 - DOI: 10.1021/acs.bioconjchem.6b00524

  • Pucci F, Rickelt S, Newton AP, Garris C, Nunes E, Evavold C, Pfirschke C, Engblom C, Mino-Kenudson M, Hynes RO, Weissleder R, Pittet MJ PF4 Promotes Platelet Production and Lung Cancer Growth. Cell Rep. 2016;17(7):1764-1772 - PMID: 27829148 - PMCID: PMC5108525 - DOI: 10.1016/j.celrep.2016.10.031

  • Giedt RJ, Fumene Feruglio P, Pathania D, Yang KS, Kilcoyne A, Vinegoni C, Mitchison TJ, Weissleder R Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response. Sci Rep. 2016;6:32985 - PMID: 27609668 - PMCID: PMC5017129 - DOI: 10.1038/srep32985

  • Park KS, Chung HJ, Khanam F, Lee H, Rashu R, Bhuiyan MT, Berger A, Harris JB, Calderwood SB, Ryan ET, Qadri F, Weissleder R, Charles RC A magneto-DNA nanoparticle system for the rapid and sensitive diagnosis of enteric fever. Sci Rep. 2016;6:32878 - PMID: 27605393 - PMCID: PMC5015101 - DOI: 10.1038/srep32878

  • Weissleder R, Schwaiger MC, Gambhir SS, Hricak H Imaging approaches to optimize molecular therapies. Sci Transl Med. 2016;8(355):355ps16 - PMID: 27605550 - DOI: 10.1126/scitranslmed.aaf3936

  • Hong S, Pirovich D, Kilcoyne A, Huang CH, Lee H, Weissleder R Supramolecular Metallo-Bioadhesive for Minimally Invasive Use. Adv Mater. 2016;28(39):8675-8680 - PMID: 27515068 - PMCID: PMC5144581 - DOI: 10.1002/adma.201602606

  • Dutta P, Hoyer FF, Sun Y, Iwamoto Y, Tricot B, Weissleder R, Magnani JL, Swirski FK, Nahrendorf M E-Selectin Inhibition Mitigates Splenic HSC Activation and Myelopoiesis in Hypercholesterolemic Mice With Myocardial Infarction. Arterioscler Thromb Vasc Biol. 2016;36(9):1802-8 - PMID: 27470513 - PMCID: PMC5001901 - DOI: 10.1161/ATVBAHA.116.307519

  • Clardy SM, Kohler RH, Vinegoni C, Iwamoto Y, Keliher EJ, Weissleder R Two-photon imaging of pancreatic beta cells in real time in vivo. Technology. 2016;4(2):130-134

  • Sager HB, Hulsmans M, Lavine KJ, Beltrami Moreira MB, Heidt T, Courties G, Sun Y, Iwamoto Y, Tricot B, Khan OF, Dahlman JE, Borodovsky A, Fitzgerald K, Anderson DG, Weissleder R, Libby P, Swirski FK, Nahrendorf M Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure. Circ Res. 2016;119(7):853-64 - PMID: 27444755 - PMCID: PMC5378496 - DOI: 10.1161/CIRCRESAHA.116.309001

  • Pathania D*, Im H*, Kilcoyne A, Sohani AR, Fexon L, Pivovarov M, Abramson JS, Randall TC, Chabner BA, Weissleder R, Lee H, Castro CM Holographic Assessment of Lymphoma Tissue (HALT) for Global Oncology Field Applications. Theranostics. 2016;6(10):1603-10 - PMID: 27446494 - PMCID: PMC4955059 - DOI: 10.7150/thno.15534

  • Theurl I, Hilgendorf I, Nairz M, Tymoszuk P, Haschka D, Asshoff M, He S, Gerhardt LM, Holderried TA, Seifert M, Sopper S, Fenn AM, Anzai A, Rattik S, McAlpine C, Theurl M, Wieghofer P, Iwamoto Y, Weber GF, Harder NK, Chousterman BG, Arvedson TL, McKee M, Wang F, Lutz OM, Rezoagli E, Babitt JL, Berra L, Prinz M, Nahrendorf M, Weiss G, Weissleder R, Lin HY, Swirski FK On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver. Nature Med. 2016;22(8):945-951 - PMID: 27428900 - PMCID: PMC4957133 - DOI: 10.1038/nm.4146

  • Meimetis LG, Giedt R, Mikyla H, Carlson J, Kohler R, Pirovich DB, Weissleder R Fluorescent vinblastine probes for live cell imaging. Chem Commun. 2016;52(64):9953-6 - PMID: 27439765 - PMCID: PMC4970878 - DOI: 10.1039/c6cc04129a

  • Vinegoni C, Dubach JM, Feruglio PF, Weissleder R Two-Photon Fluorescence Anisotropy Microscopy for Imaging and Direct Measurement of Intracellular Drug Target Engagement. IEEE J Sel Top Quant. 2016;22 (3):6801607 - PMID: 27440991 - PMCID: PMC4946648 - DOI: 10.1109/JSTQE.2015.2501384

  • Sager HB, Dutta P, Dahlman JE, Hulsmans M, Courties G, Sun Y, Heidt T, Vinegoni C, Borodovsky A, Fitzgerald K, Wojtkiewicz GR, Iwamoto Y, Tricot B, Khan OF, Kauffman KJ, Xing Y, Shaw TE, Libby P, Langer R, Weissleder R, Swirski FK, Anderson DG, Nahrendorf M RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction. Sci Transl Med. 2016;8:342 - PMID: 27280687 - PMCID: PMC5125383 - DOI: 10.1126/scitranslmed.aaf1435

  • Park KS*, Huang CH*, Lee K, Yoo YE, Castro CM, Weissleder R, Lee H Rapid identification of health care–associated infections with an integrated fluorescence anisotropy system. Sci Adv. 2016;2(5):e1600300 - PMID: 28861468 - PMCID: PMC5565941 - DOI: 10.1126/sciadv.1600300

  • Cho CF, Lee K, Speranza MC, Bononi FC, Viapiano MS, Luyt LG, Weissleder R, Chiocca EA, Lee H, Lawler SE Design of a microfluidic chip for magnetic-activated sorting of one-bead-one-compound libraries. ACS Comb Sci. 2016;18(6):271-8 - PMID: 27124678 - PMCID: PMC5321554 - DOI: 10.1021/acscombsci.5b00180

  • Song J, Leon Swisher C, Im H, Jeong S, Pathania D, Iwamoto Y, Pivovarov M, Weissleder R, Lee H Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography. Sci Rep. 2016;6:24681 - PMID: 27098438 - PMCID: PMC4838824 - DOI: 10.1038/srep24681

  • Vinegoni C, Leon Swisher C, Fumene Feruglio P, Giedt RJ, Rousso DL, Stapleton S, Weissleder R Real-time high dynamic range laser scanning microscopy. Nat Commun. 2016;7:11077 - PMID: 27032979 - PMCID: PMC4821995 - DOI: 10.1038/ncomms11077

  • Ricklefs F, Mineo M, Rooj AK, Nakano I, Charest A, Weissleder R, Breakefield XO, Chiocca EA, Godlewski J, Bronisz A Extracellular vesicles from high grade glioma exchange diverse pro-oncogenic signals that maintain intratumoral heterogeneity. Cancer Res. 2016;76(10):2876-2881 - PMID: 27013191 - PMCID: PMC4873326 - DOI: 10.1158/0008-5472.CAN-15-3432

  • Miller MA, Oudin MJ, Sullivan RJ, Wang SJ, Meyer AS, Im H, Frederick DT, Tadros J, Griffith LG, Lee H, Weissleder R, Flaherty KT, Gertler FB, Lauffenburger DA Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance. Cancer Discov. 2016;6(4):382-99 - PMID: 26984351 - PMCID: PMC5087317 - DOI: 10.1158/2159-8290.CD-15-0933

  • Im H, Park YI, Pathania D, Castro CM, Weissleder R, Lee H Digital diffraction detection of protein markers for avian influenza. Lab Chip. 2016;16(8):1340-5 - PMID: 26980325 - PMCID: PMC4829473 - DOI: 10.1039/c5lc01558h

  • Pucci F, Garris C, Lai CP, Newton A, Pfirschke C, Engblom C, Alvarez D, Sprachman M, Evavold C, Magnuson A, von Andrian UH, Glatz K, Breakefield XO, Mempel TR, Weissleder R, Pittet MJ SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions. Science. 2016;352(6282):242-246 - PMID: 26989197 - PMCID: PMC4960636 - DOI: 10.1126/science.aaf1328

  • King K, Grazette LP, Paltoo DN, McDevitt JT, Sia SK, Barrett PM, Apple FS, Gurbel PA, Weissleder R, Leeds H, Iturriaga EJ, Rao A, Adhikari B, Desvigne-Nickens P, Galis ZS, Libby P Point-of-Care Technologies for Precision Cardiovascular Care and Clinical Research: National Heart, Lung, and Blood Institute Working Group. JACC Basic Transl Sci. 2016;1(1-2):73-86 - PMID: 26977455 - PMCID: PMC4787294 - DOI: 10.1016/j.jacbts.2016.01.008

  • Cameron-Vendrig A, Reheman A, Siraj MA, Xu XR, Wang Y, Lei X, Afroze T, Shikatani E, El-Mounayri O, Noyan H, Weissleder R, Ni H, Husain M Glucagon-like peptide-1 receptor activation attenuates platelet aggregation and thrombosis. Diabetes. 2016;65(6):1714-23 - PMID: 26936963 - DOI: 10.2337/db15-1141

  • Roy J*, Kim B*, Hill E, Visconti P, Krapf D, Vinegoni C, Weissleder R, Brown D, Breton S Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging. Nat Commun. 2016;7:10666 - PMID: 26868824 - PMCID: PMC4754344 - DOI: 10.1038/ncomms10666

  • Pfirschke C, Engblom C, Rickelt S, Cortez-Retamozo V, Garris C, Pucci F, Yamasaki T, Poirier-Colame V, Newton A, Redouane Y, Lin YJ, Wojtkiewicz G, Iwamoto Y, Mino-Kenudson M, Huynh TG, Hynes RO, Freeman GJ Kroemer G, Zitvogel L, Weissleder R, Pittet MJ Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy. Immunity. 2016;44:1-12 - PMID: 26872698 - PMCID: PMC4758865 - DOI: 10.1016/j.immuni.2015.11.024

  • Jeong S, Park J, Pathania D, Castro CM, Weissleder R, Lee H Integrated Magneto-Electrochemical Sensor for Exosome Analysis. ACS Nano. 2016;10(2):1802-1809 - PMID: 26808216 - PMCID: PMC4802494 - DOI: 10.1021/acsnano.5b07584

  • Hong S, Carlson J, Lee H, Weissleder R Bioorthogonal Radiopaque Hydrogel for Endoscopic Delivery and Universal Tissue Marking. Adv Healthc Mater. 2016;5(4):421-426 - PMID: 26688173 - PMCID: PMC4811597 - DOI: 10.1002/adhm.201500780

  • Meimetis LG, Boros E, Carlson JC, Ran C, Caravan P, Weissleder R Bioorthogonal fluorophore linked DFO - Technology enabling facile chelator quantification and multimodal imaging of antibodies. Bioconjug Chem. 2016;27(1):257-63 - PMID: 26684717 - PMCID: PMC4858350 - DOI: 10.1021/acs.bioconjchem.5b00630

  • Rashidian M, Keliher E, Dougan M, Juras PK, Cavallari M, Wojtkiewicz GR, Jacobsen J, Edens JG, Tas JM, Victora G, Weissleder R, Ploegh H The use of (18)F-2-fluorodeoxyglucose (FDG) to label antibody fragments for immuno-PET of pancreatic cancer. ACS Cent Sci. 2015;1(3):142-147 - PMID: 26955657 - PMCID: PMC4778250 - DOI: 10.1021/acscentsci.5b00121

  • Koo H, Choi M, Kim E, Hahn SK, Weissleder R, Yun SH Bioorthogonal Click Chemistry-Based Synthetic Cell Glue. Small. 2015;11(48):6458-66 - PMID: 26768353 - PMCID: PMC5556392 - DOI: 10.1002/smll.201502972

  • Kuijten MM, Hannah Degeling M, Chen JW, Wojtkiewicz G, Waterman P, Weissleder R, Azzi J, Nicolay K, Tannous BA Multimodal targeted high relaxivity thermosensitive liposome for in vivo imaging. Sci Rep. 2015;5:17220 - PMID: 26610702 - PMCID: PMC4661695 - DOI: 10.1038/srep17220

  • Weissleder R, Nahrendorf M Advancing biomedical imaging. Proc Natl Acad Sci U S A. 2015;112(47):14424-8 - PMID: 26598657 - PMCID: PMC4664297 - DOI: 10.1073/pnas.1508524112

  • Miller MA, Gadde S, Pfirschke C, Engblom C, Sprachman MM, Kohler RH, Yang KS, Laughney AM, Wojtkiewicz G, Kamal N, Bhonagiri S, Pittet MJ, Farokhzad OC, Weissleder R Predicting therapeutic nano-medicine efficacy using a companion MR imaging nanoparticle. Sci Transl Med. 2015;7:314 - PMID: 26582898 - PMCID: PMC5462466 - DOI: 10.1126/scitranslmed.aac6522

  • Ullal AV, Weissleder R Photocleavable DNA Barcoding Antibodies for Multiplexed Protein Analysis in Single Cells. Methods Mol Biol. 2015;1346:47-54 - PMID: 26542714 - DOI: 10.1007/978-1-4939-2987-0_4

  • Miller MA, Zheng YR, Gadde S, Pfirschke C, Zope H, Engblom C, Kohler RH, Iwamoto Y, Yang KS, Askevold B, Kolishetti N, Pittet M, Lippard SJ, Farokhzad OC, Weissleder R Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug. Nat Commun. 2015;6:8692 - PMID: 26503691 - PMCID: PMC4711745 - DOI: 10.1038/ncomms9692

  • Vinegoni C, Aguirre AD, Lee S, Weissleder R Imaging the beating heart in the mouse using intravital microscopy techniques. Nat Protoc. 2015;10(11):1802-1819 - PMID: 26492138 - PMCID: PMC5380003 - DOI: 10.1038/nprot.2015.119

  • Park KS, Charles RC, Ryan ET, Weissleder R*, Lee H* Fluorescence polarization-based nucleic acid testing for rapid and cost-effective diagnosis of infectious disease. Chem Eur J. 2015;21(46):16359-63 - PMID: 26420633 - PMCID: PMC4816641 - DOI: 10.1002/chem.201502934

  • Ye YX, Calcagno C, Binderup T, Courties G, Keliher E, Wojtkiewicz GR, Iwamoto Y, Tang J, Perez-Medina C, Mani V, Ishino S, Johnbeck CB, Knigge U, Fayad ZA, Libby P, Weissleder R, Tawakol A, Dubey S, Belanger AP, Di Carli MF, Swirski FK, Kjær A, Mulder W, Nahrendorf M Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis. Circ Res. 2015;117(10):835-45 - PMID: 26394773 - PMCID: PMC4619168 - DOI: 10.1161/CIRCRESAHA.115.307024

  • Whitley MJ, Weissleder R, Kirsch DG Tailoring Adjuvant Radiation Therapy by Intraoperative Imaging to Detect Residual Cancer. Semin Radiat Oncol. 2015;25(4):313-21 - PMID: 26384279 - PMCID: PMC4575408 - DOI: 10.1016/j.semradonc.2015.05.005

  • Sager HB, Heidt T, Hulsmans M, Dutta P, Courties G, Sebas M, Wojtkiewicz GR, Tricot B, Iwamoto Y, Sun Y, Weissleder R, Libby P, Swirski FK, Nahrendorf M Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction. Circulation. 2015;132(20):1880-90 - PMID: 26358260 - PMCID: PMC4651795 - DOI: 10.1161/CIRCULATIONAHA.115.016160

  • Clardy SM, James F. Mohan JF, Vinegoni C, Keliher EJ, Iwamoto Y, Benoist C, Mathis D, Weissleder R Rapid, high efficiency isolation of pancreatic ß-cells. Sci Rep. 2015;5:13681 - PMID: 26330153 - PMCID: PMC4557033 - DOI: 10.1038/srep13681

  • Lee H, Shin TH, Cheon J, Weissleder R Recent Developments in Magnetic Diagnostic Systems. Chem Rev. 2015;115(19):10690-724 - PMID: 26258867 - PMCID: PMC5791529 - DOI: 10.1021/cr500698d

  • He S, Chousterman BG, Fenn A, Anzai A, Nairz M, Brandt M, Hilgendorf I, Sun Y, Ye YX, Iwamoto Y, Tricot B, Weissleder R, Macphee C, Libby P, Nahrendorf M, Swirski FK Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages. Circ Heart Fail. 2015;8(5):980-7 - PMID: 26232205 - PMCID: PMC4568849 - DOI: 10.1161/CIRCHEARTFAILURE.115.002334

  • Konishi M, Erdem SS, Weissleder R, Lichtman AH, McCarthy J, Libby P Imaging Granzyme B Activity Assesses Immune-Mediated Myocarditis. Circ Res. 2015;117(6):502-12 - PMID: 26199323 - PMCID: PMC4553143 - DOI: 10.1161/CIRCRESAHA.115.306364

  • Chung HJ, Pellegrini KL, Chung J, Wanigasuriya K, Jayawardene I, Lee K, Lee H, Vaidya VS, Weissleder R Nanoparticle Detection of Urinary Markers for Point-of-Care Diagnosis of Kidney Injury. PLoS ONE. 2015;10(7):e0133417 - PMID: 26186708 - PMCID: PMC4506142 - DOI: 10.1371/journal.pone.0133417

  • Abazari A, Meimetis LG, Budin G, Bale SS, Weissleder R, Toner M Engineered Trehalose Permeable to Mammalian Cells. PLoS ONE. 2015;10(6):e0130323 - PMID: 26115179 - PMCID: PMC4482662 - DOI: 10.1371/journal.pone.0130323

  • Park YI, Im H, Weissleder R, Lee H Nanostar clustering improves the sensitivity of plasmonic assays. Bioconjug Chem. 2015;26(8):1470-1474 - PMID: 26102604 - PMCID: PMC5292976 - DOI: 10.1021/acs.bioconjchem.5b00343

  • Glenn DR#, Lee K#, Park H, Weissleder R, Yacoby A, Lukin MD, Lee H*, Walsworth RL*, Connolly CB* Single-cell magnetic imaging using a quantum diamond microscope. Nat Methods. 2015;12(8):736-738 - PMID: 26098019 - PMCID: PMC4521973 - DOI: 10.1038/nmeth.3449

  • Tawakol A, Hara T, Truelove J, Wojtkiewicz GR, Hucker WJ, MacNabb MH, Brownell AL, Jokivarsi K, Kessinger CW, Jaff MR, Henke PK, Weissleder R, Jaffer FA Response to Letter Regarding Article, "18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Enables the Detection of Recurrent Same-Site Deep Vein Thrombosis by Illuminating Recently Formed, Neutrophil-Rich Thrombus". Circulation. 2015;131(24):e531-2 - PMID: 26078375 - DOI: 10.1161/CIRCULATIONAHA.115.014802

  • Vinegoni C, Lee S, Aguirre AD, Weissleder R New techniques for motion-artifact-free in vivo cardiac microscopy. Front Physiol. 2015;6:147 - PMID: 26029116 - PMCID: PMC4428079 - DOI: 10.3389/fphys.2015.00147

  • Kim E, Yang K, Kohler R, Dubach JM, Mikula H, Weissleder R Optimized Near-IR fluorescent agents for in vivo imaging of Btk expression. Bioconjug Chem. 2015;26(8):1513-1518 - PMID: 26017814 - PMCID: PMC4772718 - DOI: 10.1021/acs.bioconjchem.5b00152

  • Vinegoni C, Dubach JM, Thurber GM, Miller MA, Mazitschek R, Weissleder R Advances in measuring single-cell pharmacokinetics and pharmacology in vivo. Drug Discov Today. 2015;20(9):1087-92 - PMID: 26024776 - PMCID: PMC4567932 - DOI: 10.1016/j.drudis.2015.05.011

  • Turetsky A, Lee K, Song J, Giedt RJ, Kim E, Kovach AE, Hochberg EP, Castro CM, Lee H, Weissleder R On chip analysis of CNS lymphoma in cerebrospinal fluid. Theranostics. 2015;5(8):796-804 - PMID: 26000053 - PMCID: PMC4440438 - DOI: 10.7150/thno.11220

  • Yang KS, Kohler RH, Landon M, Giedt R, Weissleder R Single cell resolution in vivo imaging of DNA damage following PARP inhibition. Sci Rep. 2015;5:10129 - PMID: 25984718 - PMCID: PMC4434991 - DOI: 10.1038/srep10129

  • Lai CP, Kim EY, Badr CE, Weissleder R, Mempel TR, Tannous BA, Breakefield XO Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters. Nat Commun. 2015;6:7029 - PMID: 25967391 - PMCID: PMC4435621 - DOI: 10.1038/ncomms8029

  • Shao H, Chung J, Lee K, Balaj L, Min C, Carter BS, Hochberg FH, Breakefield XO, Lee H*, Weissleder R* Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma. Nat Commun. 2015;6:6999 - PMID: 25959588 - PMCID: PMC4430127 - DOI: 10.1038/ncomms7999

  • Dutta P, Sager HB, Stengel KR, Naxerova K, Courties G, Saez B, Silberstein L, Heidt T, Sebas M, Sun Y, Wojtkiewicz G, Feruglio PF, King K, Baker JN, van der Laan AM, Borodovsky A, Fitzgerald K, Hulsmans M, Hoyer F, Iwamoto Y, Vinegoni C, Brown D, Di Carli M, Libby P, Hiebert SW, Scadden DT, Swirski FK, Weissleder R, Nahrendorf M Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells. Cell Stem Cell. 2015;16 (5):477-487 - PMID: 25957903 - PMCID: PMC4426344 - DOI: 10.1016/j.stem.2015.04.008

  • Im H, Shao H, Weissleder R, Castro CM, Lee H Nano-plasmonic exosome diagnostics. Expert Rev Mol Diagn. 2015;:1-9 - PMID: 25936957 - PMCID: PMC4675626 - DOI: 10.1586/14737159.2015.1041378

  • Rashidian M, Keliher EJ, Bilate AM, Duarte JN, Wojtkiewicz GR, Jacobsen JT, Cragnolini J, Swee LK, Victora GD, Weissleder R, Ploegh HL Noninvasive imaging of immune responses. Proc Natl Acad Sci U S A. 2015;112(19):6146-51 - PMID: 25902531 - PMCID: PMC4434737 - DOI: 10.1073/pnas.1502609112

  • Chittajallu DR, Florian S, Kohler RH, Iwamoto Y, Orth JD, Weissleder R*, Danuser G*, Mitchison TJ* In vivo cell-cycle profiling in xenograft tumors by quantitative intravital microscopy. Nat Methods. 2015;12(6):577-585 - PMID: 25867850 - PMCID: PMC4579269 - DOI: 10.1038/nmeth.3363

  • Im H, Castro CM, Shao H, Liong M, Song J, Pathania D, Fexon L, Min C, Avila-Wallace M, Zurkiya O, Rho J, Magaoay B, Tambouret RH, Pivovarov M, Weissleder R*, Lee H* Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone. Proc Natl Acad Sci U S A. 2015;112(18):5613-8 - PMID: 25870273 - PMCID: PMC4426451 - DOI: 10.1073/pnas.1501815112

  • Dutta P, Hoyer FF, Grigoryeva LS, Sager HB, Leuschner F, Courties G, Borodovsky A, Novobrantseva T, Ruda VM, Fitzgerald K, Iwamoto Y, Wojtkiewicz G, Sun Y, Da Silva N, Libby P, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M Macrophages retain hematopoietic stem cells in the spleen via VCAM-1. J Exp Med. 2015;212(4):497-512 - PMID: 25800955 - PMCID: PMC4387283 - DOI: 10.1084/jem.20141642

  • Nair AV, Keliher EJ, Core AB, Brown D, Weissleder R Characterizing the Interactions of Organic Nanoparticles with Renal Epithelial Cells in Vivo. ACS Nano. 2015;9(4):3641-53 - PMID: 25790730 - PMCID: PMC4414893 - DOI: 10.1021/acsnano.5b00428

  • Weber GF, Chousterman BG, He S, Fenn AM, Nairz M, Anzai A, Brenner T, Uhle F, Iwamoto Y, Robbins CS, Noiret L, Maier SL, Zönnchen T, Rahbari NN, Schölch S, Klotzsche-von Ameln A, Chavakis T, Weitz J, Hofer S, Weigand MA, Nahrendorf M, Weissleder R, Swirski FK Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis. Science. 2015;347(6227):1260-1265 - PMID: 25766237 - PMCID: PMC4376966 - DOI: 10.1126/science.aaa4268

  • Chen S, Sanjana NE, Zheng K, Shalem O, Lee K, Shi X, Scott DA, Song J, Pan JQ, Weissleder R, Lee H, Zhang F, Sharp PA Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis. Cell. 2015;160(6):1246-60 - PMID: 25748654 - PMCID: PMC4380877 - DOI: 10.1016/j.cell.2015.02.038

  • Kessinger CW, Kim JW, Henke PK, Thompson B, McCarthy JR, Hara T, Sillesen M, Margey RJ, Libby P, Weissleder R, Lin CP, Jaffer FA Statins Improve the Resolution of Established Murine Venous Thrombosis: Reductions in Thrombus Burden and Vein Wall Scarring. PLoS ONE. 2015;10(2):e0116621 - PMID: 25680183 - PMCID: PMC4334538 - DOI: 10.1371/journal.pone.0116621

  • Lee K, Shao H, Weissleder R, Lee H Acoustic Purification of Extracellular Microvesicles. ACS Nano. 2015;9(3):2321-7 - PMID: 25672598 - PMCID: PMC4373978 - DOI: 10.1021/nn506538f

  • Gaglia JL, Harisinghani M, Aganj I, Wojtkiewicz GR, Hedgire S, Benoist C Mathis D, Weissleder R Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients. Proc Natl Acad Sci U S A. 2015;112(7):2139-44 - PMID: 25650428 - PMCID: PMC4343112 - DOI: 10.1073/pnas.1424993112

  • Magnuson AM, Thurber GM, Kohler RH, Weissleder R, Mathis D, Benoist C Population dynamics of islet-infiltrating cells in autoimmune diabetes. Proc Natl Acad Sci U S A. 2015;112(5):1511-6 - PMID: 25605891 - PMCID: PMC4321317 - DOI: 10.1073/pnas.1423769112

  • Langer R, Weissleder R Nanotechnology. JAMA. 2015;313(2):135-136 - PMID: 25585320 - DOI: 10.1001/jama.2014.16315

  • Courties G, Herisson F, Sager H, Heidt T, Ye Y, Ying W, Sun Y, Severe N, Dutta P, Scharff J, Scadden D, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M Ischemic Stroke Activates Hematopoietic Bone Marrow Stem Cells. Circ Res. 2015;116(3):407-17 - PMID: 25362208 - PMCID: PMC4312511 - DOI: 10.1161/CIRCRESAHA.116.305207

  • Alagesan B, Contino G, Guimaraes AR, Corcoran RB, Desphande V, Wojtkiewicz GR, Hezel AF, Wong KK, Loda M, Weissleder R, Benes CH, Engelman JA, Bardeesy N Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer. Clin Cancer Res. 2015;21(2):396-404 - PMID: 25348516 - PMCID: PMC4447091 - DOI: 10.1158/1078-0432.CCR-14-1591

  • Leuschner F, Courties G, Dutta P, Mortensen LJ, Gorbatov R, Sena B, Novobrantseva TI, Borodovsky A, Fitzgerald K, Koteliansky V, Iwamoto Y, Bohlender M, Meyer S, Lasitschka F, Meder B, Katus HA, Lin C, Libby P, Swirski FK, Anderson DG, Weissleder R, Nahrendorf M Silencing of CCR2 in myocarditis. Eur Heart J. 2015;36(23):1478-88 - PMID: 24950695 - PMCID: PMC4465633 - DOI: 10.1093/eurheartj/ehu225

  • Alieva M, Ritsma L, Giedt RJ, Weissleder R, van Rheenen J Imaging windows for long-term intravital imaging: general overview. Intravital. 2014;3:2: e29917

  • Shen K, Luk S, Hicks DF, Elman JS, Bohr S, Iwamoto Y, Murray R, Pena K, Wang F, Seker E, Weissleder R, Yarmush ML, Toner M, Sgroi D, Parekkadan B Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays. Nat Commun. 2014;5:5662 - PMID: 25489927 - PMCID: PMC4261930 - DOI: 10.1038/ncomms6662

  • Fu W, Farache J, Clardy SM, Hattori K, Mander P, Lee K, Rioja I, Weissleder R, Prinjha RK, Benoist C, Mathis D Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells. eLife. 2014;3:e04631 - PMID: 25407682 - PMCID: PMC4270084 - DOI: 10.7554/eLife.04631

  • Laughney AM, Kim E, Sprachman MM, Miller MA, Kohler RH, Yang KS, Orth JD, Mitchison TJ, Weissleder R Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin. Sci Transl Med. 2014;6 (261):261ra152 - PMID: 25378644 - PMCID: PMC4330962 - DOI: 10.1126/scitranslmed.3009318

  • Giedt RJ, Sprachman M, Yang K, Weissleder R Imaging cellular distribution of Bcl inhibitors using small molecule drug conjugates. Bioconjug Chem. 2014;25(11):2081-2085 - PMID: 25333750 - PMCID: PMC4240345 - DOI: 10.1021/bc500433k

  • Taqueti VR, Di Carli MF, Jerosch-Herold M, Sukhova GK, Murthy VL, Folco EJ, Kwong RY, Ozaki CK, Belkin M, Nahrendorf M, Weissleder R, Libby P Increased Microvascularization and Vessel Permeability Associate with Active Inflammation in Human Atheromata. Circ Cardiovasc Imaging. 2014;7(6):920-929 - PMID: 25170063 - PMCID: PMC4237630 - DOI: 10.1161/CIRCIMAGING.114.002113

  • Dubach JM, Vinegoni C, Weissleder R Steady state anisotropy two-photon microscopy resolves multiple, spectrally similar fluorophores, enabling in vivo multilabel imaging. Opt Lett. 2014;39(15):4482-4485 - PMID: 25078208 - PMCID: PMC4341989 - DOI: 10.1364/OL.39.004482

  • Hara T, Truelove J, Tawakol A, Wojtkiewicz GR, Hucker WJ, MacNabb MH, Brownell AL, Jokivarsi K, Kessinger CW, Jaff MR, Henke PK, Weissleder R, Jaffer FA FDG-PET/CT Enables the Detection of Recurrent Same-Site Deep Vein Thrombosis by Illuminating Recently Formed, Neutrophil-Rich Thrombus. Circulation. 2014;130(13):1044-52 - PMID: 25070665 - PMCID: PMC4174982 - DOI: 10.1161/CIRCULATIONAHA.114.008902

  • Aguirre AD, Vinegoni C, Sebas M, Weissleder R Intravital imaging of cardiac function at the single-cell level. Proc Natl Acad Sci U S A. 2014;111(31):11257-62 - PMID: 25053815 - PMCID: PMC4128110 - DOI: 10.1073/pnas.1401316111

  • Stangenberg L, Burzyn D, Binstadt BA, Weissleder R, Mahmood U, Benoist C, Mathis D Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature. Proc Natl Acad Sci U S A. 2014;111(31):11419-24 - PMID: 25049388 - PMCID: PMC4128122 - DOI: 10.1073/pnas.1410854111

  • Heidt T, Sager HB, Courties G, Dutta P, Iwamoto Y, Zaltsman A, von Zur Muhlen C, Bode C, Fricchione GL, Denninger J, Lin CP, Vinegoni C, Libby P, Swirski FK, Weissleder R, Nahrendorf M Chronic variable stress activates hematopoietic stem cells. Nature Med. 2014;20(7):754-758 - PMID: 24952646 - PMCID: PMC4087061 - DOI: 10.1038/nm.3589

  • Meimetis LG, Carlson JC, Giedt RJ, Kohler RH, Weissleder R Ultrafluorogenic Coumarin-Tetrazine Probes for Real-Time Biological Imaging. Angew Chem Int Ed Engl. 2014;53(29):7531-4 - PMID: 24915832 - PMCID: PMC4122131 - DOI: 10.1002/anie.201403890

  • Issadore D, Park YI, Shao H, Min C, Lee K, Liong M, Weissleder R*, Lee H* Magnetic sensing technology for molecular analyses. Lab Chip. 2014;14(14):2385-97 - PMID: 24887807 - PMCID: PMC4098149 - DOI: 10.1039/c4lc00314d

  • Dubach JM, Vinegoni C, Mazitschek R, Fumene Feruglio P, Cameron LA, Weissleder R In vivo imaging of specific drug-target binding at subcellular resolution. Nat Commun. 2014;5:3946 - PMID: 24867710 - PMCID: PMC4362617 - DOI: 10.1038/ncomms4946

  • Weber GF, Chousterman BG, Hilgendorf I, Robbins CS, Theurl I, Gerhardt LM, Iwamoto Y, Quach TD, Ali M, Chen JW, Rothstein TL, Nahrendorf M, Weissleder R, Swirski FK Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis. J Exp Med. 2014;211(6):1243-56 - PMID: 24821911 - PMCID: PMC4042649 - DOI: 10.1084/jem.20131471

  • Sprachman M, Laughney A, Kohler R, Weissleder R In Vivo Imaging of Multidrug Resistance Using a Third Generation MDR1 Inhibitor. Bioconjug Chem. 2014;25(6):1137-42 - PMID: 24806886 - PMCID: PMC4098115 - DOI: 10.1021/bc500154c

  • Zeglis BM, Emmetiere F, Pillarsetty N, Weissleder R, Lewis JS, Reiner T Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid-Phase Peptide Synthesis. ChemistryOpen. 2014;3(2):48-53 - PMID: 24808990 - PMCID: PMC4000166 - DOI: 10.1002/open.201402000

  • Heidt T, Courties G, Dutta P, Sager H, Sebas M, Iwamoto Y, Sun Y, Da Silva N, Panizzi P, van der Laan AM, Swirski FK, Weissleder R, Nahrendorf M Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction. Circ Res. 2014;115(2):284-95 - PMID: 24786973 - PMCID: PMC4082439 - DOI: 10.1161/CIRCRESAHA.115.303567

  • Turetsky A, Kim E, Kohler RH, Miller MA, Weissleder R Single cell imaging of Bruton's tyrosine kinase using an irreversible inhibitor. Sci Rep. 2014;4:4782 - PMID: 24759210 - PMCID: PMC3998017 - DOI: 10.1038/srep04782

  • Morton AM, Sefik E, Upadhyay R, Weissleder R, Benoist C, Mathis D Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut. Proc Natl Acad Sci U S A. 2014;111(18):6696-701 - PMID: 24753589 - PMCID: PMC4020091 - DOI: 10.1073/pnas.1405634111

  • Im H*, Shao H*, Park YI, Peterson VM, Castro CM, Weissleder R*, Lee H* Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor. Nat Biotechnol. 2014;32(5):490-5 - PMID: 24752081 - PMCID: PMC4356947 - DOI: 10.1038/nbt.2886

  • Lee S, Vinegoni C, Sebas M, Weissleder R Automated motion artifact removal for intravital microscopy, without a priori information. Sci Rep. 2014;4:4507 - PMID: 24676021 - PMCID: PMC3968488 - DOI: 10.1038/srep04507

  • Kim E, Yang KS, Giedt RJ, Weissleder R Red Si-rhodamine drug conjugates enable imaging in GFP cells. Chem Commun. 2014;50(34):4504-7 - PMID: 24663433 - PMCID: PMC4028821 - DOI: 10.1039/c4cc00144c

  • Winkler DA, Burden FR, Yan B, Weissleder R, Tassa C, Shaw S, Epa VC Modelling and predicting the biological effects of nanomaterials. SAR QSAR Environ Res. 2014;25(2):161-72 - PMID: 24625316 - DOI: 10.1080/1062936X.2013.874367

  • Hilgendorf I, Gerhardt L, Tan TC, Winter C, Holderried TA, Chousterman BG, Iwamoto Y, Liao R, Zirlik A, Scherrer-Crosbie M, Hedrick CC, Libby P, Nahrendorf M, Weissleder R, Swirski FK Ly-6Chigh Monocytes Depend on Nr4a1 to Balance both Inflammatory and Reparative Phases in the Infarcted Myocardium. Circ Res. 2014;114(10):1611-22 - PMID: 24625784 - PMCID: PMC4017349 - DOI: 10.1161/CIRCRESAHA.114.303204

  • Keliher EJ, Klubnick JA Reiner T, Mazitschek R, Weissleder R Efficient Acid-Catalyzed (18) F/(19) F Fluoride Exchange of BODIPY Dyes. ChemMedChem. 2014;9(7):1368-73 - PMID: 24596307 - PMCID: PMC4145401 - DOI: 10.1002/cmdc.201300506

  • Elman JS, Murray RM, Wang F, Shen K, Gao S, Conway KE, Yarmush ML, Tannous BA, Weissleder R, Parekkadan B Pharmacokinetics of natural and engineered secreted factors delivered by mesenchymal stromal cells. PLoS ONE. 2014;9(2):e89882 - PMID: 24587097 - PMCID: PMC3931832 - DOI: 10.1371/journal.pone.0089882

  • Thurber G, Reiner T, Yang K, Kohler R, Weissleder R Effect of Small Molecule Modification on Single Cell Pharmacokinetics of PARP Inhibitors. Mol Cancer Ther. 2014;13(4):986-95 - PMID: 24552776 - PMCID: PMC3981972 - DOI: 10.1158/1535-7163.MCT-13-0801

  • Liong M, Im H, Majmudar MD, Aguirre AD, Sebas M, Lee H*, Weissleder R* Magnetic Ligation Method for Quantitative Detection of MicroRNAs. Adv Healthc Mater. 2014;3(7):1015-9 - PMID: 24532323 - PMCID: PMC4107040 - DOI: 10.1002/adhm.201300672

  • Miller MA, Askevold B, Yang KS, Kohler RH, Weissleder R Platinum Compounds for High-Resolution In Vivo Cancer Imaging. ChemMedChem. 2014;9(6):1131-5 - PMID: 24504646 - PMCID: PMC4037345 - DOI: 10.1002/cmdc.201300502

  • Bronisz A, Wang Y, Nowicki MO, Peruzzi P, Ansari KI, Ogawa D, Balaj L, De Rienzo G, Mineo M, Nakano I, Ostrowski MC, Hochberg F, Weissleder R, Lawler SE, Chiocca EA, Godlewski J Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1. Cancer Res. 2014;74(3):738-50 - PMID: 24310399 - PMCID: PMC3928601 - DOI: 10.1158/0008-5472.CAN-13-2650

  • Hilgendorf I, Theurl I, Gerhardt LM, Robbins CS, Weber GF, Gonen A, Iwamoto Y, Degousee N, Holderried TA, Winter C, Zirlik A, Lin HY, Sukhova GK, Butany J, Rubin BB, Witztum JL, Libby P, Nahrendorf M, Weissleder R, Swirski FK Innate Response Activator B Cells Aggravate Atherosclerosis by Stimulating TH1 Adaptive Immunity. Circulation. 2014;129(16):1677-87 - PMID: 24488984 - PMCID: PMC3997655 - DOI: 10.1161/CIRCULATIONAHA.113.006381

  • Weissleder R, Nahrendorf M, Pittet MJ Imaging macrophages with nanoparticles. Nat Mater. 2014;13(2):125-38 - PMID: 24452356 - DOI: 10.1038/nmat3780

  • Ullal AV*, Peterson V*, Agasti SS, Tuang S, Juric D, Castro CM, Weissleder R Cancer Cell Profiling by Barcoding Allows Multiplexed Protein Analysis in Fine-Needle Aspirates. Sci Transl Med. 2014;6(219):219ra9 - PMID: 24431113 - PMCID: PMC4063286 - DOI: 10.1126/scitranslmed.3007361

  • Courties G, Heidt T, Sebas M, Iwamoto Y, Jeon D, Truelove J, Tricot B, Wojtkiewicz G, Dutta P, Sager HB, Borodovsky A, Novobrantseva T, Klebanov B, Fitzgerald K, Anderson DG, Libby P, Swirski FK, Weissleder R, Nahrendorf M In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing. J Am Coll Cardiol. 2014;63(15):1556-66 - PMID: 24361318 - PMCID: PMC3992176 - DOI: 10.1016/j.jacc.2013.11.023

  • Vinegoni C, Lee S, Feruglio PF, Weissleder R Advanced Motion Compensation Methods for Intravital Optical Microscopy. IEEE J Sel Top Quant. 2014;20(2):ePub - PMID: 24273405 - PMCID: PMC3832946 - DOI: 10.1109/JSTQE.2013.2279314

  • Ghazani A, Pectasides M, Sharma A, Castro CM, Mino-Kenudson M, Lee H, Shepard JA, Weissleder R Molecular characterization of scant lung tumor cells using iron-oxide nanoparticles and micro-nuclear magnetic resonance. Nanomedicine. 2014;10 :661-668 - PMID: 24200523 - PMCID: PMC3966960 - DOI: 10.1016/j.nano.2013.10.008

  • McDermott S, Thayer SP, Fernandez-Del Castillo C, Mino-Kenudson M, Weissleder R, Harisinghani MG Accurate prediction of nodal status in preoperative patients with pancreatic ductal adenocarcinoma using next-gen nanoparticle. Transl Oncol. 2013;6(6):670-5 - PMID: 24466369 - PMCID: PMC3890701 - DOI: 10.1593/tlo.13400

  • Coffey SE, Giedt RJ, Weissleder R Automated analysis of clonal cancer cells by intravital imaging. Intravital. 2013;2(3):ePub - PMID: 24349895 - PMCID: PMC3859690 - DOI: 10.4161/intv.26138

  • Rho J, Chung J, Im H, Liong M, Shao H, Castro CM, Weissleder R, Lee H Magnetic Nanosensor for Detection and Profiling of Erythrocyte-Derived Microvesicles. ACS Nano. 2013;7(12):11227-33 - PMID: 24295203 - PMCID: PMC3898036 - DOI: 10.1021/nn405016y

  • Peterson VM*, Castro CM*, Chung J, Miller NC, Ullal AV, Castano MD, Penson RT, Lee H, Birrer MJ, Weissleder R Ascites analysis by a microfluidic chip allows tumor-cell profiling. Proc Natl Acad Sci U S A. 2013;110(51):E4978-86 - PMID: 24297935 - PMCID: PMC3870756 - DOI: 10.1073/pnas.1315370110

  • Kim E, Yang K, Weissleder R Bioorthogonal Small Molecule Imaging Agents Allow Single-Cell Imaging of MET. PLoS ONE. 2013;8 (11):e81275 - PMID: 24265843 - PMCID: PMC3827223 - DOI: 10.1371/journal.pone.0081275

  • Vinegoni C, Lee S, Feruglio PF, Marzola P, Nahrendorf M, Weissleder R Sequential average segmented microscopy for high signal-to-noise ratio motion-artifact-free in vivo heart imaging. Biomed Opt Express. 2013;4(10):2095-106 - PMID: 24156067 - PMCID: PMC3799669 - DOI: 10.1364/BOE.4.002095

  • Agasti SS, Laughney AM, Kohler RH, Weissleder R A photoactivatable drug–caged fluorophore conjugate allows direct quantification of intracellular drug transport. Chem Commun. 2013;49(94):11050-2 - PMID: 24135896 - PMCID: PMC3856557 - DOI: 10.1039/c3cc46089d

  • Tassa C, Liong M, Hilderbrand S, Sandler JE, Reiner T, Keliher EJ, Weissleder R, Shaw SY Microfluidic On-chip Capture-cycloaddition Reaction to Reversibly Immobilize Small Molecules or Multi-component Structures for Biosensor Applications. J Vis Exp. 2013;(79):e50772 - PMID: 24084440 - PMCID: PMC3924759 - DOI: 10.3791/50772

  • Chung J*, Issadore D*, Ullal A*, Lee K, Weissleder R*, Lee H* Rare cell isolation and profiling on a hybrid magnetic/size-sorting chip. Biomicrofluidics. 2013;7(5):54107 - PMID: 24404070 - PMCID: PMC3790798 - DOI: 10.1063/1.4821923

  • Yoon TJ, Shao H, Weissleder R, Lee H Oxidation Kinetics and Magnetic Properties of Elemental Iron Nanoparticles. Part. Part. Syst. Charact. 2013;30:667–671 - PMID: 24077230 - PMCID: PMC3783348 - DOI: 10.1002/ppsc.201300013

  • Yang* KS, Budin* G, Tassa C, Kister O, Weissleder R Bioorthogonal Approach to Identify Unsuspected Drug Targets in Live Cells. Angew Chem Int Ed Engl. 2013;52(40):10593-7 - PMID: 23960025 - PMCID: PMC3856564 - DOI: 10.1002/anie.201304096

  • Robbins CS, Hilgendorf I, Weber GF, Theurl I, Iwamoto Y, Figueiredo JL, Gorbatov R, Sukhova GK, Gerhardt LM, Smyth D, Zavitz CC, Shikatani EA, Parsons M, Rooijen NV, Lin HY, Husain M, Libby P, Nahrendorf M, Weissleder R, Swirski FK Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nature Med. 2013;19(9):1166-72 - PMID: 23933982 - PMCID: PMC3769444 - DOI: 10.1038/nm.3258

  • Keliher EJ, Reiner T, Earley S, Klubnick J, Tassa C, Lee AJ, Ramaswamy S, Bardeesy N, Hanahan D, Depinho RA, Castro CM, Weissleder R Targeting cathepsin e in pancreatic cancer by a small molecule allows in vivo detection. Neoplasia. 2013;15(7):684-93 - PMID: 23814481 - PMCID: PMC3689232 - DOI: 10.1593/neo.13276

  • Ueno T, Dutta P, Keliher E, Leuschner F, Majmudar M, Marinelli B, Iwamoto Y, Figueiredo JL, Christen T, Swirski FK, Libby P, Weissleder R, Nahrendorf M Nanoparticle PET-CT Detects Rejection and Immunomodulation in Cardiac Allografts. Circ Cardiovasc Imaging. 2013;6(4):568-73 - PMID: 23771986 - PMCID: PMC3734553 - DOI: 10.1161/CIRCIMAGING.113.000481

  • Carlson JC, Meimetis LG, Hilderbrand SA, Weissleder R BODIPY-Tetrazine Derivatives as Superbright Bioorthogonal Turn-on Probes. Angew Chem Int Ed Engl. 2013;52(27):6917-6920 - PMID: 23712730 - PMCID: PMC3875324 - DOI: 10.1002/anie.201301100

  • Zeglis BM, Sevak KK, Reiner T, Mohindra P, Carlin SD, Zanzonico P, Weissleder R, Lewis JS A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels-Alder Click Chemistry. J Nucl Med. 2013;54(8):1389-96 - PMID: 23708196 - PMCID: PMC4151562 - DOI: 10.2967/jnumed.112.115840

  • Chung HJ, Castro CM, Im H, Lee H*, Weissleder R* A magneto-DNA nanoparticle system for rapid detection and phenotyping of bacteria. Nat Nanotechnol. 2013;8(5):369-75 - PMID: 23644570 - PMCID: PMC3711657 - DOI: 10.1038/nnano.2013.70

  • Majmudar MD, Keliher EJ, Heidt T, Leuschner F, Truelove J, Sena BF, Gorbatov R, Iwamoto Y, Dutta P, Wojtkiewicz G, Courties G, Sebas M, Borodovsky A, Fitzgerald K, Nolte MW, Dickneite G, Chen JW, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice. Circulation. 2013;127(20):2038-2046 - PMID: 23616627 - PMCID: PMC3661714 - DOI: 10.1161/CIRCULATIONAHA.112.000116

  • Liong M, Hoang AN, Chung J, Gural N, Ford CB, Min C, Shah RR, Ahmad R, Fernandez-Suarez M, Fortune SM, Toner M, Lee H*, Weissleder R* Magnetic barcode assay for genetic detection of pathogens. Nat Commun. 2013;4:1752 - PMID: 23612293 - PMCID: PMC3635151 - DOI: 10.1038/ncomms2745

  • Shan G, Weissleder R, Hilderbrand SA Upconverting Organic Dye Doped Core-Shell Nano-Composites for Dual-Modality NIR Imaging and Photo-Thermal Therapy. Theranostics. 2013;3(4):267-74 - PMID: 23606913 - PMCID: PMC3630527 - DOI: 10.7150/thno.5226

  • Gounaris E, Martin J, Ishihara Y, Khan MW, Lee G, Sinh P, Chen EZ, Angarone M, Weissleder R, Khazaie K, Barrett TA Fluorescence Endoscopy of Cathepsin Activity Discriminates Dysplasia from Colitis. Inflamm Bowel Dis. 2013;19(7):1339-1345 - PMID: 23591598 - PMCID: PMC4306589 - DOI: 10.1097/MIB.0b013e318281f3f8

  • Giedt RJ, Koch PD, Weissleder R Single Cell Analysis of Drug Distribution by Intravital Imaging. PLoS ONE. 2013;8(4):e60988 - PMID: 23593370 - PMCID: PMC3622689 - DOI: 10.1371/journal.pone.0060988

  • Ghazani AA, McDermott S, Pectasides M, Sebas M, Mino-Kenudson M, Lee H, Weissleder R, Castro CM Comparison of select cancer biomarkers in human circulating and bulk tumor cells using magnetic nanoparticles and miniaturized micro-NMR system. Nanomedicine (Lond). 2013;9(7):1009-17 - PMID: 23570873 - PMCID: PMC4330975 - DOI: 10.1016/j.nano.2013.03.011

  • Issadore D*, Chung HJ*, Chung J, Budin G, Weissleder R*, Lee H* μHall Chip for Sensitive Detection of Bacteria. Adv Healthc Mater. 2013;2(9):1224-8 - PMID: 23495188 - PMCID: PMC4340655 - DOI: 10.1002/adhm.201200380

  • Thurber GM, Yang KS, Reiner T, Kohler RH, Sorger P, Mitchison T, Weissleder R Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nat Commun. 2013;4:1504 - PMID: 23422672 - PMCID: PMC3579506 - DOI: 10.1038/ncomms2506

  • Liu R, Rallo R, Weissleder R, Tassa C, Shaw S, Cohen Y Nano-SAR Development for Bioactivity of Nanoparticles with Considerations of Decision Boundaries. Small. 2013;9(9-10):1842-52 - PMID: 23423856 - DOI: 10.1002/smll.201201903

  • Cortez-Retamozo V, Etzrodt M, Newton A, Ryan R, Pucci F, Sio SW, Kuswanto W, Rauch PJ, Chudnovskiy A, Iwamoto Y, Kohler R, Marinelli B, Gorbatov R, Wojtkiewicz G, Panizzi P, Mino-Kenudson M, Forghani R, Figueiredo JL, Chen JW, Xavier R, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ Angiotensin II Drives the Production of Tumor-Promoting Macrophages. Immunity. 2013;38(2):296-308 - PMID: 23333075 - PMCID: PMC3582771 - DOI: 10.1016/j.immuni.2012.10.015

  • Majmudar MD, Yoo J, Keliher E, Truelove JJ, Iwamoto Y, Sena B, Dutta P, Borodovsky A, Fitzgerald K, Di Carli MF, Libby P, Anderson D, Swirski FK, Weissleder R, Nahrendorf M Polymeric Nanoparticle PET/MR Imaging Allows Macrophage Detection in Atherosclerotic Plaques. Circ Res. 2013;112(5):755-61 - PMID: 23300273 - PMCID: PMC3586287 - DOI: 10.1161/CIRCRESAHA.111.300576

  • Agasti SS, Kohler RH, Liong M, Peterson VM, Lee H, Weissleder R Dual Imaging and Photoactivated Nanoprobe for Controlled Cell Tracking. Small. 2013;9(2):222-7 - PMID: 22996932 - PMCID: PMC3552149 - DOI: 10.1002/smll.201201007

  • Feruglio PF, Vinegoni C, Fexon L, Thurber G, Sbarbati A, Weissleder R Noise suppressed, multifocus image fusion for enhanced intraoperative navigation. J Biophotonics. 2013;6(4):363-70 - PMID: 22887724 - PMCID: PMC3779878 - DOI: 10.1002/jbio.201200086

  • Keliher EJ, Reiner T, Thurber GM, Upadhyay R, Weissleder R Efficient (18)F-Labeling of Synthetic Exendin-4 Analogues for Imaging Beta Cells. ChemistryOpen. 2012;1(4):177-183 - PMID: 23997998 - PMCID: PMC3758109 - DOI: 10.1002/open.201200014

  • Novobrantseva TI, Borodovsky A, Wong J, Klebanov B, Zafari M, Yucius K, Querbes W, Ge P, Ruda VM, Milstein S, Speciner L, Duncan R, Barros S, Basha G, Cullis P, Akinc A, Donahoe JS, Narayanannair Jayaprakash K, Jayaraman M, Bogorad RL, Love K, Whitehead K, Levins C, Manoharan M, Swirski FK, Weissleder R, Langer R, Anderson DG, de Fougerolles A, Nahrendorf M, Koteliansky V Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells. Mol Ther Nucleic Acids. 2012;1:e4 - PMID: 23344621 - PMCID: PMC3381593 - DOI: 10.1038/mtna.2011.3

  • Vinegoni C, Lee S, Gorbatov R, Weissleder R Motion compensation using a suctioning stabilizer for intravital microscopy. Intravital. 2012;1:115-121 - PMID: 24086796 - PMCID: PMC3786172 - DOI: 10.4161/intv.23017

  • Kastrup CJ, Nahrendorf M, Figueiredo JL, Lee H, Kambhampati S, Lee T, Cho SW, Gorbatov R, Iwamoto Y, Dang TT, Dutta P, Yeon JH, Cheng H, Pritchard CD, Vegas AJ, Siegel CD, Macdougall S, Okonkwo M, Thai A, Stone JR, Coury AJ, Weissleder R, Langer R, Anderson DG Painting blood vessels and atherosclerotic plaques with an adhesive drug depot. Proc Natl Acad Sci U S A. 2012;109(52):21444-9 - PMID: 23236189 - PMCID: PMC3535589 - DOI: 10.1073/pnas.1217972110

  • Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, Macdonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism. Cell. 2012;151(6):1185-99 - PMID: 23217706 - PMCID: PMC3526953 - DOI: 10.1016/j.cell.2012.10.047

  • Chen JW, Figueiredo JL, Wojtkiewicz GR, Siegel C, Iwamoto Y, Kim DE, Nolte MW, Dickneite G, Weissleder R, Nahrendorf M Selective Factor XIIa Inhibition Attenuates Silent Brain Ischemia: Application of Molecular Imaging Targeting Coagulation Pathway. JACC Cardiovasc Imaging. 2012;5(11):1127-38 - PMID: 23153913 - PMCID: PMC3502014 - DOI: 10.1016/j.jcmg.2012.01.025

  • Lee J, Li M, Milwid J, Dunham J, Vinegoni C, Gorbatov R, Iwamoto Y, Wang F, Shen K, Hatfield K, Enger M, Shafiee S, McCormack E, Ebert BL, Weissleder R, Yarmush ML, Parekkadan B Implantable microenvironments to attract hematopoietic stem/cancer cells. Proc Natl Acad Sci U S A. 2012;109(48):19638-43 - PMID: 23150542 - PMCID: PMC3511730 - DOI: 10.1073/pnas.1208384109

  • Shao H, Chung J, Balaj L, Charest A, Bigner DD, Carter BS, Hochberg FH, Breakefield XO, Weissleder R*, Lee H* Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy. Nature Med. 2012;18(12):1835-1840 - PMID: 23142818 - PMCID: PMC3518564 - DOI: 10.1038/nm.2994

  • Agasti SS, Liong M, Peterson VM, Lee H, Weissleder R Photocleavable DNA barcode-antibody conjugates allow sensitive and multiplexed protein analysis in single cell. J Am Chem Soc. 2012;134(45):18499-18502 - PMID: 23092113 - PMCID: PMC3498844 - DOI: 10.1021/ja307689w

  • Lee S, Vinegoni C, Feruglio PF, Weissleder R Improved intravital microscopy via synchronization of respiration and holder stabilization. J Biomed Opt. 2012;17(9):96018-1 - PMID: 23085919 - PMCID: PMC3449295 - DOI: 10.1117/1.JBO.17.9.096018

  • Epa VC, Burden FR, Tassa C, Weissleder R, Shaw SY, Winkler DA Modelling biological activities of nanoparticles. Nano Lett. 2012;12(11):5808-5812 - PMID: 23039907 - DOI: 10.1021/nl303144k

  • Ripplinger CM, Kessinger CW, Li C, Kim JW, McCarthy JR, Weissleder R, Henke PK, Lin CP, Jaffer FA Inflammation Modulates Murine Venous Thrombosis Resolution In Vivo: Assessment by Multimodal Fluorescence Molecular Imaging. Arterioscler Thromb Vasc Biol. 2012;32(11):2616-24 - PMID: 22995524 - PMCID: PMC3516622 - DOI: 10.1161/ATVBAHA.112.251983

  • Lee S, Vinegoni C, Feruglio PF, Fexon L, Gorbatov R, Pivovarov M, Sbarbati A, Nahrendorf M, Weissleder R Real-time in vivo imaging of the beating mouse heart at microscopic resolution. Nat Commun. 2012;3:1054 - PMID: 22968700 - PMCID: PMC3622400 - DOI: 10.1038/ncomms2060

  • Lu X, Agasti SS, Vinegoni C, Waterman P, Depinho R, Weissleder R Optochemogenetics (OCG) allows more precise control of genetic engineering in mice with CreER regulators. Bioconjug Chem. 2012;23(9):1945-51 - PMID: 22917215 - PMCID: PMC3775343 - DOI: 10.1021/bc300319c

  • Waters JD, Sanchez C, Sahin A, Futalan D, Gonda DD, Scheer JK, Akers J, Palanichamy K, Waterman P, Chakravarti A, Weissleder R, Morse B, Marsh N, Furfine E, Chen CC, Carvajal I, Carter BS CT322, a VEGFR-2 antagonist, demonstrates anti-glioma efficacy in orthotopic brain tumor model as a single agent or in combination with temozolomide and radiation therapy. J Neurooncol. 2012;110(1):37-48 - PMID: 22875706 - PMCID: PMC4291475 - DOI: 10.1007/s11060-012-0948-7

  • Chung J*, Shao H*, Reiner T, Issadore D, Weissleder R, Lee H Cell Sorting: Microfluidic Cell Sorter (μFCS) for On-chip Capture and Analysis of Single Cells. Adv Healthc Mater. 2012;1(4):432-6 - PMID: 23184773 - PMCID: PMC3508764 - DOI: 10.1002/adhm.201200046

  • Min C, Shao H, Liong M, Yoon TJ, Weissleder R, Lee H Mechanism of Magnetic Relaxation Switching Sensing. ACS Nano. 2012;6(8):6821-8 - PMID: 22762250 - PMCID: PMC3429660 - DOI: 10.1021/nn301615b

  • Tassa C, Liong M, Hilderbrand S, Sandler JE, Reiner T, Keliher EJ, Weissleder R, Shaw SY On-chip bioorthogonal chemistry enables immobilization of in situ modified nanoparticles and small molecules for label-free monitoring of protein binding and reaction kinetics. Lab Chip. 2012;12(17):3103-10 - PMID: 22760641 - PMCID: PMC3411869 - DOI: 10.1039/c2lc40337d

  • Issadore D, Chung J*, Shao H*, Liong M, Ghazani AA, Castro CM, Weissleder R*, Lee H* Ultrasensitive Clinical Enumeration of Rare Cells ex Vivo Using a Micro-Hall Detector. Sci Transl Med. 2012;4 (141):141ra92 - PMID: 22764208 - PMCID: PMC3603277 - DOI: 10.1126/scitranslmed.3003747

  • Budin G*, Chung HJ*, Lee H, Weissleder R A Magnetic Gram Stain for Bacterial Detection. Angew Chem Int Ed Engl. 2012;51(31):7752-5 - PMID: 22744868 - PMCID: PMC3496380 - DOI: 10.1002/anie.201202982

  • Ghazani AA, Castro CM, Gorbatov R, Lee H, Weissleder R Sensitive and Direct Detection of Circulating Tumor Cells by Multimarker µ-Nuclear Magnetic Resonance. Neoplasia. 2012;14(5):388-95 - PMID: 22745585 - PMCID: PMC3384426 - DOI: 10.1596/neo.12696

  • Dutta P*, Courties G*, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, Thompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AN, Niessen HWM, Piek JJ, Rubin BB, Butany J, Stone JR, Katus HA, Murphy SA, Morrow DA, Sabatine MS, Vinegoni C, Moskowitz MA, Pittet MJ, Libby P, Lin CP, Swirski FK, Weissleder R, Nahrendorf M Myocardial infarction accelerates atherosclerosis. Nature. 2012;487(7407):325-9 - PMID: 22763456 - PMCID: PMC3401326 - DOI: 10.1038/nature11260

  • Hara T, Bhayana B, Thompson B, Kessinger CW, Khatri A, McCarthy JR, Weissleder R, Lin CP, Tearney GJ, Jaffer FA Molecular imaging of fibrin deposition in deep vein thrombosis using fibrin-targeted near-infrared fluorescence. JACC Cardiovasc Imaging. 2012;5(6):607-15 - PMID: 22698530 - PMCID: PMC3376390 - DOI: 10.1016/j.jcmg.2012.01.017

  • Fukuda D, Aikawa E, Swirski FK, Novobrantseva TI, Kotelianski V, Gorgun CZ, Chudnovskiy A, Yamazaki H, Croce K, Weissleder R, Aster JC, Hotamisligil GS, Yagita H, Aikawa M Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Proc Natl Acad Sci U S A. 2012;109(27):E1868-77 - PMID: 22699504 - PMCID: PMC3390871 - DOI: 10.1073/pnas.1116889109

  • Yang KS, Budin G, Reiner T, Vinegoni C, Weissleder R Bioorthogonal Imaging of Aurora Kinase A in Live Cells. Angew Chem Int Ed Engl. 2012;51(27):6598-603 - PMID: 22644700 - PMCID: PMC3523717 - DOI: 10.1002/anie.201200994

  • Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik JH, Lim C, Guimaraes AR, Martin ES, Chang J, Hezel AF, Perry SR, Hu J, Gan B, Xiao Y, Asara JM, Weissleder R, Wang YA, Chin L, Cantley LC, Depinho RA Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism. Cell. 2012;149(3):656-70 - PMID: 22541435 - PMCID: PMC3472002 - DOI: 10.1016/j.cell.2012.01.058

  • Vinegoni C, Feruglio PF, Razansky D, Gorbatov R, Ntziachristos V, Sbarbati A, Nahrendorf M, Weissleder R Mapping molecular agents distributions in whole mice hearts using born-normalized optical projection tomography. PLoS ONE. 2012;7(4):e34427 - PMID: 22509302 - PMCID: PMC3324534 - DOI: 10.1371/journal.pone.0034427

  • Liu X, Nielsen GP, Rosenberg AE, Waterman PR, Yang W, Choy E, Sassi S, Yang S, Harmon DC, Yang C, Schwab JH, Kobayashi E, Mankin HJ, Xavier R, Weissleder R, Duan Z, Hornicek FJ Establishment and characterization of a novel chordoma cell line: CH22. J Orthop Res. 2012;30(10):1666-73 - PMID: 22504929 - DOI: 10.1002/jor.22113

  • Earley S, Vinegoni C, Dunham J, Gorbatov R, Fumene Feruglio P, Weissleder R In vivo imaging of drug-induced mitochondrial outer membrane permeabilization at single cell resolution. Cancer Res. 2012;72(12):2949-56 - PMID: 22505651 - PMCID: PMC3603290 - DOI: 10.1158/0008-5472.CAN-11-4096

  • Etzrodt M, Cortez-Retamozo V, Newton A, Zhao J, Ng A, Wildgruber M, Romero P, Wurdinger T, Xavier RJ, Geissmann F, Meylan E, Nahrendorf M, Swirski FK, Baltimore D, Weissleder R, Pittet MJ Regulation of Monocyte Functional Heterogeneity by miR-146a and Relb. Cell Rep. 2012;1(4):1-8 - PMID: 22545247 - PMCID: PMC3334310 - DOI: 10.1016/j.celrep.2012.02.009

  • Hendricks JA, Keliher EJ, Wan D, Hilderbrand SA, Weissleder R, Mazitschek R Synthesis of [(18) F]BODIPY: Bifunctional Reporter for Hybrid Optical/Positron Emission Tomography Imaging. Angew Chem Int Ed Engl. 2012;51(19):4603-6 - PMID: 22473535 - PMCID: PMC3343182 - DOI: 10.1002/anie.201107957

  • Reiner T, Lacy J, Keliher EJ, Yang KS, Ullal A, Kohler RH, Vinegoni C, Weissleder R Imaging Therapeutic PARP Inhibition In Vivo through Bioorthogonally Developed Companion Imaging Agents. Neoplasia. 2012;14(3):169-177 - PMID: 22496617 - PMCID: PMC3323895 - DOI: 10.1593/neo.12414

  • Forghani R, Wojtkiewicz GR, Zhang Y, Seeburg D, Bautz BR, Pulli B, Milewski AR, Atkinson WL, Iwamoto Y, Zhang ER, Etzrodt M, Rodriguez E, Robbins CS, Swirski FK, Weissleder R, Chen JW Demyelinating Diseases: Myeloperoxidase as an Imaging Biomarker and Therapeutic Target. Radiology. 2012;263(2):451-60 - PMID: 22438365 - PMCID: PMC3329272 - DOI: 10.1148/radiol.12111593

  • Peterson VM, Castro CM, Lee H, Weissleder R Orthogonal Amplification of Nanoparticles for Improved Diagnostic Sensing. ACS Nano. 2012;6(4):3506-13 - PMID: 22424443 - PMCID: PMC3337350 - DOI: 10.1021/nn300536y

  • Devaraj NK, Thurber GM, Keliher EJ, Marinelli B, Weissleder R Reactive polymer enables efficient in vivo bioorthogonal chemistry. Proc Natl Acad Sci U S A. 2012;109(13):4762-7 - PMID: 22411831 - PMCID: PMC3324005 - DOI: 10.1073/pnas.1113466109

  • Niers JM*, Chen JW*, Lewandrowski G, Kerami M, Garanger E, Wojtkiewicz G, Waterman P, Keliher E, Weissleder R, Tannous BA Single Reporter for Targeted Multimodal in Vivo Imaging. J Am Chem Soc. 2012;134(11):5149-56 - PMID: 22397453 - PMCID: PMC3310895 - DOI: 10.1021/ja209868g

  • Fu W, Wojtkiewicz G, Weissleder R, Benoist C, Mathis D Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging. Nat Immunol. 2012;13(4):361-8 - PMID: 22366893 - PMCID: PMC3309063 - DOI: 10.1038/ni.2233

  • McCarthy JR, Sazonova IY, Erdem SS, Hara T, Thompson BD, Patel P, Botnaru I, Lin CP, Reed GL, Weissleder R, Jaffer FA Multifunctional nanoagent for thrombus-targeted fibrinolytic therapy. Nanomedicine (Lond). 2012;7(7):1017-28 - PMID: 22348271 - PMCID: PMC3360120 - DOI: 10.2217/nnm.11.179

  • Rao SM, Auger JL, Gaillard P, Weissleder R, Wada E, Torres R, Kojima M, Benoist C, Mathis D, Binstadt BA The neuropeptide neuromedin U promotes autoantibody-mediated arthritis. Arthritis Res Ther. 2012;14(1):R29 - PMID: 22314006 - PMCID: PMC3392824 - DOI: 10.1186/ar3732

  • Cortez-Retamozo V, Etzrodt M, Newton A, Rauch PJ, Chudnovskiy A, Berger C, Ryan RJ, Iwamoto Y, Marinelli B, Gorbatov R, Forghani R, Novobrantseva TI, Koteliansky V, Figueiredo JL, Chen JW, Anderson DG, Nahrendorf M, Swirski FK, Weissleder R, Pittet MJ Origins of tumor-associated macrophages and neutrophils. Proc Natl Acad Sci U S A. 2012;109(7):2491-6 - PMID: 22308361 - PMCID: PMC3289379 - DOI: 10.1073/pnas.1113744109

  • Shao H, Min C, Issadore D, Liong M, Yoon TJ, Weissleder R, Lee H Magnetic Nanoparticles and microNMR for Diagnostic Applications. Theranostics. 2012;2(1):55-65 - PMID: 22272219 - PMCID: PMC3263516 - DOI: 10.7150/thno.3465

  • Rauch PJ*, Chudnovskiy A*, Robbins CS*, Weber GF, Etzrodt M, Hilgendorf I, Tiglao E, Figueiredo JL, Iwamoto Y, Theurl I, Gorbatov R, Waring MT, Chicoine AT, Mouded M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK Innate Response Activator B Cells Protect Against Microbial Sepsis. Science. 2012;335(6068):597-601 - PMID: 22245738 - PMCID: PMC3279743 - DOI: 10.1126/science.1215173

  • Leuschner F, Rauch PJ, Ueno T, Gorbatov R, Marinelli B, Lee WW, Dutta P, Wei Y, Robbins C, Iwamoto Y, Sena B, Chudnovskiy A, Panizzi P, Keliher E, Higgins JM, Libby P, Moskowitz MA, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis. J Exp Med. 2012;209(1):123-37 - PMID: 22213805 - PMCID: PMC3260875 - DOI: 10.1084/jem.20111009

  • Lee WW, Marinelli B, van der Laan AM, Sena BF, Gorbatov R, Leuschner F, Dutta P, Iwamoto Y, Ueno T, Begieneman MPV, Niessen HWM, Piek JJ, Vinegoni C, Pittet MJ, Swirski FK, Tawakol A, Di Carli M, Weissleder R, Nahrendorf M PET/MRI of Inflammation in Myocardial Infarction. J Am Coll Cardiol. 2012;59:153-163 - PMID: 22222080 - PMCID: PMC3257823 - DOI: 10.1016/j.jacc.2011.08.066

  • Karver MR, Weissleder R, Hilderbrand SA Bioorthogonal Reaction Pairs Enable Simultaneous, Selective, Multi-Target Imaging. Angew Chem Int Ed Engl. 2012;51(4):920-2 - PMID: 22162316 - PMCID: PMC3304098 - DOI: 10.1002/anie.201104389

  • Agasti SS, Liong M, Tassa C, Chung HJ, Shaw SY, Lee H, Weissleder R Supramolecular Host-Guest Interaction for Labeling and Detection of Cellular Biomarkers. Angew Chem Int Ed Engl. 2012;51(2):450-4 - PMID: 22113923 - PMCID: PMC3309171 - DOI: 10.1002/anie.201105670

  • Su HS, Nahrendorf M, Panizzi PR, Breckwoldt MO, Rodriguez E, Iwamoto Y, Aikawa E, Weissleder R, Chen JW Vasculitis: Molecular Imaging by Targeting the Inflammatory Enzyme Myeloperoxidase. Radiology. 2012;262(1):181-90 - PMID: 22084204 - PMCID: PMC3244672 - DOI: 10.1148/radiol.11110040

  • Zhang W, Fulci G, Buhrman JS, Stemmer-Rachamimov AO, Chen JW, Wojtkiewicz GR, Weissleder R, Rabkin SD, Martuza RL Bevacizumab With Angiostatin-armed oHSV Increases Antiangiogenesis and Decreases Bevacizumab-induced Invasion in U87 Glioma. Mol Ther. 2012;20(1):37-45 - PMID: 21915104 - PMCID: PMC3255598 - DOI: 10.1038/mt.2011.187

  • Thomas S, Waterman P, Chen S, Marinelli B, Seaman M, Rodig S, Ross RW, Josephson L, Weissleder R, Kelly KA Development of Secreted Protein and Acidic and Rich in Cysteine (SPARC) Targeted Nanoparticles for the Prognostic Molecular Imaging of Metastatic Prostate Cancer. J Nanomedic Nanotechnol. 2011;2(4):112 - PMID: 22319675 - PMCID: PMC3273319 - DOI: 10.4172/2157-7439.1000112

  • Pittet MJ, Weissleder R Intravital imaging. Cell. 2011;147(5):983-91 - PMID: 22118457 - PMCID: PMC3824153 - DOI: 10.1016/j.cell.2011.11.004

  • Weissleder R, Castro C Interview: Nanomedicine in oncology: miniaturized means to an enormous end. Nanomedicine (Lond). 2011;6(9):1495-8 - PMID: 22077461 - DOI: 10.2217/nnm.11.138

  • Liong M, Fernandez-Suarez M, Issadore D, Min C, Tassa C, Reiner T, Fortune SM, Toner M, Lee H, Weissleder R Specific Pathogen Detection Using Bioorthogonal Chemistry and Diagnostic Magnetic Resonance. Bioconjug Chem. 2011;22(12):2390-4 - PMID: 22043803 - PMCID: PMC3263317 - DOI: 10.1021/bc200490r

  • Keliher E, Yoo J, Nahrendorf M, Lewis JS, Marinelli B, Newton A, Pittet M, Weissleder R 89Zr Labeled Dextran Nanoparticles Enable in vivo Macrophage Imaging. Bioconjug Chem. 2011;22(12):2383-9 - PMID: 22035047 - PMCID: PMC3244512 - DOI: 10.1021/bc200405d

  • Settles M, Etzrodt M, Kosanke K, Schiemann M, Zimmermann A, Meier R, Braren R, Huber A, Rummeny EJ, Weissleder R, Swirski FK, Wildgruber M Different capacity of monocyte subsets to phagocytose iron-oxide nanoparticles. PLoS ONE. 2011;6(10):e25197 - PMID: 21984904 - PMCID: PMC3184946 - DOI: 10.1371/journal.pone.0025197

  • Leuschner F, Dutta P, Gorbatov R, Novobrantseva TI, Donahoe JS, Courties G, Lee KM, Kim JI, Markmann JF, Marinelli B, Panizzi P, Lee WW, Iwamoto Y, Milstein S, Epstein-Barash H, Cantley W, Wong J, Cortez-Retamozo V, Newton A, Love K, Libby P, Pittet MJ, Swirski FK, Koteliansky V, Langer R, Weissleder R, Anderson DG, Nahrendorf M Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol. 2011;29(11):1005-10 - PMID: 21983520 - PMCID: PMC3212614 - DOI: 10.1038/nbt.1989

  • Ullal AV, Reiner T, Yang KS, Gorbatov R, Min C, Issadore D, Lee H, Weissleder R Nanoparticle Mediated Measurement of Target-Drug Binding in Cancer Cells. ACS Nano. 2011;5(11):9216-24 - PMID: 21962084 - PMCID: PMC3297118 - DOI: 10.1021/nn203450p

  • Chung H, Reiner T, Budin G, Min C, Liong M, Issadore D, Lee H, Weissleder R Ubiquitous Detection of Gram-Positive Bacteria with Bioorthogonal Magnetofluorescent Nanoparticles. ACS Nano. 2011;5(11):8834-41 - PMID: 21967150 - PMCID: PMC3222727 - DOI: 10.1021/nn2029692

  • Budin G, Yang KS, Reiner T, Weissleder R Bioorthogonal Probes for Polo-like Kinase 1 Imaging and Quantification. Angew Chem Int Ed Engl. 2011;50(40):9378-81 - PMID: 21948435 - PMCID: PMC3187564 - DOI: 10.1002/anie.201103273

  • Karver M, Weissleder R, Hilderbrand SA Synthesis and Evaluation of a Series of 1,2,4,5-Tetrazines for Bioorthogonal Conjugation. Bioconjug Chem. 2011;22(11):2263-2270 - PMID: 21950520 - PMCID: PMC3254257 - DOI: 10.1021/bc200295y

  • Yoon TJ*, Lee H*, Shao H, Hilderbrand SA, Weissleder R Multicore Assemblies Potentiate Magnetic Properties of Biomagnetic Nanoparticles. Adv Mater. 2011;23(41):4793-7 - PMID: 21953810 - PMCID: PMC3224986 - DOI: 10.1002/adma.201102948

  • Thurber GM, Weissleder R A Systems Approach for Tumor Pharmacokinetics. PLoS ONE. 2011;6(9):e24696 - PMID: 21935441 - PMCID: PMC3173470 - DOI: 10.1371/journal.pone.0024696

  • Zeglis BM, Mohindra P, Weissmann GI, Divilov V, Hilderbrand SA, Weissleder R, Lewis JS A Modular Strategy for the Construction of Radiometallated Antibodies for Positron Emission Tomography Based on Inverse Electron Demand Diels-Alder Click Chemistry. Bioconjug Chem. 2011;22(10):2048-59 - PMID: 21877749 - PMCID: PMC3197258 - DOI: 10.1021/bc200288d

  • Panizzi P*, Nahrendorf M*, Jose-Luiz Figueiredo JL, Panizzi J, Marinelli B, Iwamoto Y, Keliher E, Maddur AA, Waterman P, Kroh HK, Leuschner F, Aikawa E, Swirski FK, Pittet MJ, Hackeng TM, Fuentes-Prior P, Schneewind O, Bock PE, Weissleder R In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation. Nature Med. 2011;17(9):1142-6 - PMID: 21857652 - PMCID: PMC3169740 - DOI: 10.1038/nm.2423

  • Liong M, Tassa C, Shaw SY, Lee H, Weissleder R Multiplexed Magnetic Labeling Amplification Using Oligonucleotide Hybridization. Adv Mater. 2011;23(36):H254-7 - PMID: 21780311 - PMCID: PMC3584698 - DOI: 10.1002/adma.201101401

  • Reiner T, Thurber G, Gaglia J, Vinegoni C, Liew CW, Upadhyay R, Kohler RH, Li L, Kulkarni RN, Benoist C, Mathis D, Weissleder R Accurate measurement of pancreatic islet {beta}-cell mass using a second-generation fluorescent exendin-4 analog. Proc Natl Acad Sci U S A. 2011;108(31):12815-20 - PMID: 21768367 - PMCID: PMC3150928 - DOI: 10.1073/pnas.1109859108

  • Hendricks JA, Keliher EJ, Marinelli B, Reiner T, Weissleder R, Mazitschek R In Vivo PET-imaging of Histone Deacetylases by 18F-Suberoylanilide Hydroxamic Acid (18F-SAHA). J Med Chem. 2011;54(15):5576-82 - PMID: 21721525 - PMCID: PMC3150598 - DOI: 10.1021/jm200620f

  • Orth JD, Kohler RH, Foijer F, Sorger PK, Weissleder R, Mitchison TJ Analysis of Mitosis and Antimitotic Drug Responses in Tumors by In Vivo Microscopy and Single-Cell Pharmacodynamics. Cancer Res. 2011;71(13):4608-16 - PMID: 21712408 - PMCID: PMC3129392 - DOI: 10.1158/0008-5472.CAN-11-0412

  • Jaffer FA, Calfon MA, Rosenthal A, Mallas G, Razansky RN, Mauskapf A, Weissleder R, Libby P, Ntziachristos V Two-dimensional intravascular near-infrared fluorescence molecular imaging of inflammation in atherosclerosis and stent-induced vascular injury. J Am Coll Cardiol. 2011;57(25):2516-26 - PMID: 21679853 - PMCID: PMC3123768 - DOI: 10.1016/j.jacc.2011.02.036

  • Tassa C, Shaw SY, Weissleder R Dextran-Coated Iron Oxide Nanoparticles: A Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy. Accounts Chem Res. 2011;44(10):842-52 - PMID: 21661727 - PMCID: PMC3182289 - DOI: 10.1021/ar200084x

  • Devaraj NK, Weissleder R Biomedical Applications of Tetrazine Cycloadditions. Accounts Chem Res. 2011;44(9):816-27 - PMID: 21627112 - PMCID: PMC3166440 - DOI: 10.1021/ar200037t

  • Vinegoni C, Botnaru I, Aikawa E, Calfon MA, Iwamoto Y, Folco EJ, Ntziachristos V, Weissleder R, Libby P, Jaffer FA Indocyanine Green Enables Near-Infrared Fluorescence Imaging of Lipid-Rich, Inflamed Atherosclerotic Plaques. Sci Transl Med. 2011;3 (84) ra45):84ra45 - PMID: 21613624 - PMCID: PMC3112179 - DOI: 10.1126/scitranslmed.3001577

  • Yoon TJ*, Lee H*, Shao H, Weissleder R Highly magnetic core-shell nanoparticles with a unique magnetization mechanism. Angew Chem Int Ed Engl. 2011;50(20):4663-6 - PMID: 21495138 - PMCID: PMC3334859 - DOI: 10.1002/anie.201100101

  • Buxton DB, Antman M, Danthi N, Dilsizian V, Fayad ZA, Garcia MJ, Jaff MR, Klimas M, Libby P, Nahrendorf M, Sinusas AJ, Wickline SA, Wu JC, Bonow RO, Weissleder R Report of the national heart, lung, and blood institute working group on the translation of cardiovascular molecular imaging. Circulation. 2011;123(19):2157-63 - PMID: 21576680 - PMCID: PMC3119488 - DOI: 10.1161/CIRCULATIONAHA.110.000943

  • Kleijn A*, Chen JW*, Buhrman JS, Wojtkiewicz GR, Iwamoto Y, Lamfers ML, Stemmer-Rachamimov AO, Rabkin SD, Weissleder R, Martuza RL, Fulci G Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging. Clin Cancer Res. 2011;17(13):4484-93 - PMID: 21558403 - PMCID: PMC3131449 - DOI: 10.1158/1078-0432.CCR-11-0575

  • Issadore D, Min C, Liong M, Chung J, Weissleder R, Lee H Miniature magnetic resonance system for point-of-care diagnostics. Lab Chip. 2011;11(13):2282-7 - PMID: 21547317 - PMCID: PMC3115660 - DOI: 10.1039/c1lc20177h

  • Deliolanis NC, Wurdinger T, Pike L, Tannous BA, Breakefield XO, Weissleder R, Ntziachristos V In vivo tomographic imaging of red-shifted fluorescent proteins. Biomed Opt Express. 2011;2(4):887-900 - PMID: 21483611 - PMCID: PMC3072128 - DOI: 10.1364/BOE.2.000887

  • Shao F, Yuan H, Josephson L, Weissleder R, Hilderbrand SA Facile Synthesis of Monofunctional Pentamethine Carbocyanine Fluorophores. Dyes Pigm. 2011;90(2):119-122 - PMID: 21475610 - PMCID: PMC3070263 - DOI: 10.1016/j.dyepig.2010.12.008

  • Haun JB, Yoon TJ, Lee H, Weissleder R Molecular Detection of Biomarkers and Cells Using Magnetic Nanoparticles and Diagnostic Magnetic Resonance. Methods Mol Biol. 2011;726:33-49 - PMID: 21424441 - DOI: 10.1007/978-1-61779-052-2_3

  • Keliher EJ, Reiner T, Turetsky A, Hilderbrand SA, Weissleder R High-Yielding, Two-Step (18) F Labeling Strategy for (18) F-PARP1 Inhibitors. ChemMedChem. 2011;6(3):424-7 - PMID: 21360818 - PMCID: PMC3136544 - DOI: 10.1002/cmdc.201000426

  • Haun J, Devaraj NK, Marinelli B, Lee H, Weissleder R Probing Intracellular Biomarkers and Mediators of Cell Activation Using Nanosensors and Bioorthogonal Chemistry. ACS Nano. 2011;5(4):3204-13 - PMID: 21351804 - PMCID: PMC3088084 - DOI: 10.1021/nn200333m

  • Haun JB*, Castro CM*, Wang R, Peterson VM, Marinelli BS, Lee H, Weissleder R. Micro-NMR for Rapid Molecular Analysis of Human Tumor Samples . Sci Transl Med. 2011;3(71):71ra16 - PMID: 21346169 - PMCID: PMC3086073 - DOI: 10.1126/scitranslmed.3002048

  • Reiner T, Keliher EJ, Earley S, Marinelli B, Weissleder R Synthesis and In Vivo Imaging of a (18) F-Labeled PARP1 Inhibitor Using a Chemically Orthogonal Scavenger-Assisted High-Performance Method. Angew Chem Int Ed Engl. 2011;50(8):1922-5 - PMID: 21328671 - PMCID: PMC3471140 - DOI: 10.1002/anie.201006579

  • Kirsch DG, Grimm J, Guimaraes AR, Weissleder R In response to dr. Garbow and colleagues. Int J Radiat Oncol Biol Phys. 2011;79(3):959 - PMID: 21281902

  • Nahrendorf M, Keliher E, Marinelli B, Leuschner F, Robins CS, Gerszten RE, Pittet MJ, Swirski FK, Weissleder R Detection of Macrophages in Aortic Aneurysms by Nanoparticle Positron Emission Tomography-Computed Tomography. Arterioscler Thromb Vasc Biol. 2011;31(4):750-7 - PMID: 21252070 - PMCID: PMC3060293 - DOI: 10.1161/ATVBAHA.110.221499

  • Quillard T, Croce K, Jaffer FA, Weissleder R, Libby P Molecular imaging of macrophage protease activity in cardiovascular inflammation in vivo. Thromb Haemostasis. 2011;105(5):828-36 - PMID: 21225096 - PMCID: PMC3087830 - DOI: 10.1160/TH10-09-0589

  • Niers JM, Chen JW, Weissleder R, Tannous BA Enhanced in Vivo Imaging of Metabolically Biotinylated Cell Surface Reporters. Anal Chem. 2011;83(3):994-9 - PMID: 21214190 - PMCID: PMC3059349 - DOI: 10.1021/ac102758m

  • Sun N, Yoon TJ, Lee H, Andress W, Weissleder R, Ham D Palm NMR and 1-Chip NMR. IEEE J Solid-ST Circ. 2011;46(1):342-352

  • Xia Y, Cortez-Retamozo V, Niederkofler V, Salie R, Chen S, Samad TA, Hong CC, Arber S, Vyas JM, Weissleder R, Pittet MJ, Lin HY Dragon (Repulsive Guidance Molecule b) Inhibits IL-6 Expression in Macrophages. J Immunol. 2011;186(3):1369-76 - PMID: 21187450 - PMCID: PMC3670585 - DOI: 10.4049/jimmunol.1002047

  • Figueiredo JL, Nahrendorf M, Vinegoni C, Weissleder R Intraoperative Near-infrared Fluorescent Cholangiography (NIRFC) in Mouse Models of Bile Duct Injury: Reply. World J Surg. 2011;35(3):694-5 - PMID: 20645091 - DOI: 10.1007/s00268-010-0728-5

  • Shao H, Yoon TJ, Liong M, Weissleder R, Lee H Magnetic nanoparticles for biomedical NMR-based diagnostics. Beilstein J Nanotechnol. 2010;1:142154 - PMID: 21977404 - PMCID: PMC3045933 - DOI: 10.3762/bjnano.1.17

  • Gros J, Hu JK, Vinegoni C, Feruglio PF, Weissleder R, Tabin CJ WNT5A/JNK and FGF/MAPK Pathways Regulate the Cellular Events Shaping the Vertebrate Limb Bud. Curr Top Dev Biol. 2010;20(22):1993-2002 - PMID: 21055947 - PMCID: PMC2998074 - DOI: 10.1016/j.cub.2010.09.063

  • Reiner T, Earley S, Turetsky A, Weissleder R Bioorthogonal Small-Molecule Ligands for PARP1 Imaging in Living Cells. Chembiochem. 2010;11(17):2374-2377 - PMID: 20967817 - PMCID: PMC3034378 - DOI: 10.1002/cbic.201000477

  • Morishige K, Kacher DF, Libby P, Josephson L, Ganz P, Weissleder R, Aikawa M High-Resolution Magnetic Resonance Imaging Enhanced With Superparamagnetic Nanoparticles Measures Macrophage Burden in Atherosclerosis. Circulation. 2010;122(17):1707-15 - PMID: 20937980 - PMCID: PMC3003265 - DOI: 10.1161/CIRCULATIONAHA.109.891804

  • Leuschner F, Panizzi P, Chico-Calero I, Lee WW, Ueno T, Cortez-Retamozo V, Waterman P, Gorbatov R, Marinelli B, Iwamoto Y, Chudnovskiy A, Figueiredo JL, Sosnovik DE, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M Angiotensin-Converting Enzyme Inhibition Prevents the Release of Monocytes From Their Splenic Reservoir in Mice With Myocardial Infarction. Circ Res. 2010;107(11):1364-73 - PMID: 20930148 - PMCID: PMC2992104 - DOI: 10.1161/CIRCRESAHA.110.227454

  • Thurber GM, Figueiredo JL, Weissleder R Detection limits of intraoperative near infrared imaging for tumor resection. J Surg Oncol. 2010;102(7):758-64 - PMID: 20872807 - PMCID: PMC3758114 - DOI: 10.1002/jso.21735

  • Condeelis J, Weissleder R In Vivo Imaging in Cancer. Cold Spring Harb Perspect Biol. 2010;2(12):a003848 - PMID: 20861158 - PMCID: PMC2982169 - DOI: 10.1101/cshperspect.a003848

  • Fourches D, Pu D, Tassa C, Weissleder R, Shaw SY, Mumper RJ, Tropsha A Quantitative Nanostructure-Activity Relationship Modeling. ACS Nano. 2010;4(10):5703-12 - PMID: 20857979 - PMCID: PMC2997621 - DOI: 10.1021/nn1013484

  • Liong M, Shao H, Haun JB, Lee H, Weissleder R Carboxymethylated Polyvinyl Alcohol Stabilizes Doped Ferrofluids for Biological Applications. Adv Mater. 2010;22(45):5168-72 - PMID: 20859943 - PMCID: PMC2993874 - DOI: 10.1002/adma.201002219

  • McCarthy JR, Bhaumik J, Karver MR, Sibel Erdem S, Weissleder R Targeted nanoagents for the detection of cancers. Mol Oncol. 2010;4(6):511-28 - PMID: 20851695 - PMCID: PMC2981649 - DOI: 10.1016/j.molonc.2010.08.003

  • Fumene Feruglio P, Vinegoni C, Gros J, Sbarbati A, Weissleder R Block matching 3D random noise filtering for absorption optical projection tomography. Phys Med Biol. 2010;55(18):5401-5415 - PMID: 20736500 - PMCID: PMC2934766 - DOI: 10.1088/0031-9155/55/18/009

  • McCarthy JR, Korngold E, Weissleder R, Jaffer FA A Light-Activated Theranostic Nanoagent for Targeted Macrophage Ablation in Inflammatory Atherosclerosis. Small. 2010;6(18):2041-9 - PMID: 20721949 - PMCID: PMC3018665 - DOI: 10.1002/smll.201000596

  • Chang K, Francis SA, Aikawa E, Figueiredo JL, Kohler RH, McCarthy JR, Weissleder R, Plutzky J, Jaffer FA Pioglitazone Suppresses Inflammation In Vivo in Murine Carotid Atherosclerosis. Novel Detection by Dual-Target Fluorescence Molecular Imaging. Arterioscler Thromb Vasc Biol. 2010;30(10):1933-9 - PMID: 20689078 - PMCID: PMC3030475 - DOI: 10.1161/ATVBAHA.110.206342

  • Haun JB, Devaraj NK, Hilderbrand SA, Lee H, Weissleder R Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection. Nat Nanotechnol. 2010;5(9):660-5 - PMID: 20676091 - PMCID: PMC2934903 - DOI: 10.1038/nnano.2010.148

  • Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, Kim J, Aryee MJ, Ji H, Ehrlich LI, Yabuuchi A, Takeuchi A, Cunniff KC, Hongguang H, McKinney-Freeman S, Naveiras O, Yoon TJ, Irizarry RA, Jung N, Seita J, Hanna J, Murakami P, Jaenisch R, Weissleder R, Orkin SH, Weissman IL, Feinberg AP, Daley GQ Epigenetic memory in induced pluripotent stem cells. Nature. 2010;467(7313):285-90 - PMID: 20644535 - PMCID: PMC3150836 - DOI: 10.1038/nature09342

  • Hjortnaes J, Butcher J, Figueiredo JL, Riccio M, Kohler RH, Kozloff KM, Weissleder R, Aikawa E Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation. Eur Heart J. 2010;31(16):1975-84 - PMID: 20601388 - PMCID: PMC2921509 - DOI: 10.1093/eurheartj/ehq237

  • Reiner T, Kohler RH, Liew CW, Hill JA, Gaglia J, Kulkarni RN, Weissleder R Near-Infrared Fluorescent Probe for Imaging of Pancreatic B Cells. Bioconjug Chem. 2010;21:1362-1368 - PMID: 20583828 - PMCID: PMC2912453 - DOI: 10.1021/bc100184w

  • Swirski FK, Wildgruber M, Ueno T, Figueiredo JL, Panizzi P, Iwamoto Y, Zhang E, Stone JR, Rodriguez E, Chen JW, Pittet MJ, Weissleder R, Nahrendorf M Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice. J Clin Invest. 2010;120(7):2627-34 - PMID: 20577051 - PMCID: PMC2898607 - DOI: 10.1172/JCI42304

  • Libby P, Nahrendorf M, Weissleder R Molecular imaging of atherosclerosis: a progress report. Tex Heart I J. 2010;37(3):324-7 - PMID: 20548813 - PMCID: PMC2879214

  • Taniguchi CM, Winnay J, Kondo T, Bronson RT, Guimaraes AR, Aleman JO, Luo J, Stephanopoulos G, Weissleder R, Cantley LC, Kahn CR The Phosphoinositide 3-Kinase Regulatory Subunit p85{alpha} Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling. Cancer Res. 2010;70(13):5305-5315 - PMID: 20530665 - PMCID: PMC3204358 - DOI: 10.1158/0008-5472.CAN-09-3399

  • Han HS, Devaraj NK, Lee J, Hilderbrand SA, Weissleder R, Bawendi MG Development of a Bioorthogonal and Highly Efficient Conjugation Method for Quantum Dots Using Tetrazine-Norbornene Cycloaddition. J Am Chem Soc. 2010;132(23):7838-9 - PMID: 20481508 - PMCID: PMC2892974 - DOI: 10.1021/ja101677r

  • Libby P, DiCarli M, Weissleder R The Vascular Biology of Atherosclerosis and Imaging Targets. J Nucl Med. 2010;51 Suppl 1:33S-37S - PMID: 20395349 - DOI: 10.2967/jnumed.109.069633

  • Bratlie KM, Dang TT, Lyle S, Nahrendorf M, Weissleder R, Langer R, Anderson DG Rapid biocompatibility analysis of materials via in vivo fluorescence imaging of mouse models. PLoS ONE. 2010;5(4):e10032 - PMID: 20386609 - PMCID: PMC2850367 - DOI: 10.1371/journal.pone.0010032

  • Nahrendorf M, Keliher E, Marinelli B, Waterman P, Feruglio PF, Fexon L, Pivovarov M, Swirski FK, Pittet MJ, Vinegoni C, Weissleder R Hybrid PET-optical imaging using targeted probes. Proc Natl Acad Sci U S A. 2010;107(17):7910-5 - PMID: 20385821 - PMCID: PMC2867879 - DOI: 10.1073/pnas.0915163107

  • Panizzi P, Swirski FK, Figueiredo JL, Waterman P, Sosnovik DE, Aikawa E, Libby P, Pittet M, Weissleder R, Nahrendorf M Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis. J Am Coll Cardiol. 2010;55(15):1629-38 - PMID: 20378083 - PMCID: PMC2852892 - DOI: 10.1016/j.jacc.2009.08.089

  • Vinegoni C, Fumene Feruglio P, Cortez-Retamozo V, Razansky D, Medoff BD, Ntziachristos V, Sbarbati A, Pittet M, Weissleder R Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomography. Opt Lett. 2010;35(7):1088-90 - PMID: 20364226 - PMCID: PMC2900933 - DOI: 10.1364/OL.35.001088

  • Haun JB, Yoon TJ, Lee H, Weissleder R Magnetic nanoparticle biosensors. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010;2(3):291-304 - PMID: 20336708 - DOI: 10.1002/wnan.84

  • van Eekelen M, Sasportas LS, Kasmieh R, Yip S, Figueiredo JL, Louis DN, Weissleder R, Shah K Human stem cells expressing novel TSP-1 variant have anti-angiogenic effect on brain tumors. Oncogene. 2010;29(22):3185-95 - PMID: 20305695 - PMCID: PMC3390229 - DOI: 10.1038/onc.2010.75

  • Devaraj NK, Hilderbrand S, Upadhyay R, Mazitschek R, Weissleder R Bioorthogonal Turn-On Probes for Imaging Small Molecules inside Living Cells. Angew Chem Int Ed Engl. 2010;19 (49):2869-2872 - PMID: 20306505 - PMCID: PMC3433403 - DOI: 10.1002/anie.200906120

  • Kirsch DG, Grimm J, Guimaraes AR, Wojtkiewicz GR, Perez BA, Santiago PM, Anthony NK, Forbes T, Doppke K, Weissleder R, Jacks T Imaging Primary Lung Cancers in Mice to Study Radiation Biology. Int J Radiat Oncol Biol Phys. 2010;76(4):973-977 - PMID: 20206017 - PMCID: PMC2847457 - DOI: 10.1016/j.ijrobp.2009.11.038

  • Vallet S, Mukherjee S, Vaghela N, Hideshima T, Fulciniti M, Pozzi S, Santo L, Cirstea D, Patel K, Sohani AR, Guimaraes A, Xie W, Chauhan D, Schoonmaker JA, Attar E, Churchill M, Weller E, Munshi N, Seehra JS, Weissleder R, Anderson KC, Scadden DT, Raje N Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease. Proc Natl Acad Sci U S A. 2010;107(11):5124-9 - PMID: 20194748 - PMCID: PMC2841922 - DOI: 10.1073/pnas.0911929107

  • Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1alpha. Cell. 2010;140(2):280-293 - PMID: 20141841 - PMCID: PMC2821045 - DOI: 10.1016/j.cell.2009.12.041

  • Hingtgen SD, Kasmieh R, van de Water J, Weissleder R, Shah K Determining Multiple Aspects of Stem Cell-Based Therapies Using Novel Diagnostic and Therapeutic Multifunctional Molecules. Stem Cells. 2010;28(4):832-41 - PMID: 20127797 - PMCID: PMC3021283 - DOI: 10.1002/stem.313

  • Hamilton AM, Rogers KA, Belisle AJ, Ronald JA, Rutt BK, Weissleder R, Boughner DR Early identification of aortic valve sclerosis using iron oxide enhanced MRI. J Magn Reson Imaging. 2010;31(1):110-6 - PMID: 20027578 - PMCID: PMC5638659 - DOI: 10.1002/jmri.22008

  • Rodriguez E, Nilges M, Weissleder R, Chen JW Activatable magnetic resonance imaging agents for myeloperoxidase sensing: mechanism of activation, stability, and toxicity. J Am Chem Soc. 2010;132(1):168-77 - PMID: 19968300 - PMCID: PMC2802665 - DOI: 10.1021/ja905274f

  • Figueiredo JL, Siegel C, Nahrendorf M, Weissleder R Intraoperative Near-Infrared Fluorescent Cholangiography (NIRFC) in Mouse Models of Bile Duct Injury. World J Surg. 2010;34 (2):336-343 - PMID: 20033407 - PMCID: PMC2809822 - DOI: 10.1007/s00268-009-0332-8

  • Tassa C, Duffner JL, Lewis TA, Weissleder R, Schreiber SL, Koehler AN, Shaw SY Binding Affinity and Kinetic Analysis of Targeted Small Molecule-Modified Nanoparticles. Bioconjug Chem. 2010;21:14-19 - PMID: 20028085 - PMCID: PMC2902264 - DOI: 10.1021/bc900438a

  • Martinez-Boubeta C, Balcells L, Cristool R, Sanfeliu C, Rodriguez E, Weissleder R, Lope-Piedrafita S, Simeonidis K, Angelakeris M, Sandiumenge F, Calleja A, Casas L, Monty C, Martinez B Self-assembled Multifunctional Fe/MgO Nanospheres for Magnetic Resonance Imaging and Hyperthermia. Nanomedicine. 2010;6(2):362-370 - PMID: 19800988 - DOI: 10.1016/j.nano.2009.09.003

  • Taboada E, Solanas R, Rodriguez E, Weissleder R, Roig A Supercritical-Fluid-Assisted One-Pot Synthesis of Biocompatible Core (&#947;-Fe2O3)/Shell(SiO2) Nanoparticles as High Relaxivity T2-Contrast Agents for Magnetic Resonance Imaging. Adv Funct Mater. 2009;19 :2319-2324

  • Chen S, Reynolds F, Yu L, Weissleder R, Josephson L A screening paradigm for the design of improved polymer-coated superparamagnetic iron oxide nanoparticles. J Mater Chem. 2009;19:6387-6392

  • Vinegoni C, Fexon L, Fumene Feruglio P, Pivovarov M, Figueiredo JL, Nahrendorf M, Pozzo A, Sbarbati A, Weissleder R High throughput transmission optical projection tomography using low cost graphics processing unit. Opt Express. 2009;17(25):22320-22332 - PMID: 20052155 - PMCID: PMC2805020 - DOI: 10.1364/OE.17.022320

  • Tsai CC, Vinegoni C, Weissleder R Diffractionless beam in free space with adiabatic changing refractive index in a single mode tapered slab waveguide. Opt Express. 2009;17(24):21723-31 - PMID: 19997414 - PMCID: PMC2805120 - DOI: 10.1364/OE.17.021723

  • Thurber GM, Figueiredo JL, Weissleder R Multicolor Fluorescent Intravital Live Microscopy (FILM) for Surgical Tumor Resection in a Mouse Xenograft Model. PLoS ONE. 2009;4(11):e8053 - PMID: 19956597 - PMCID: PMC2779447 - DOI: 10.1371/journal.pone.0008053

  • Sosnovik DE, Garanger E, Aikawa E, Nahrendorf M, Figuiredo JL, Dai G, Reynolds F, Rosenzweig A, Weissleder R, Josephson L Molecular MRI of Cardiomyocyte Apoptosis With Simultaneous Delayed-Enhancement MRI Distinguishes Apoptotic and Necrotic Myocytes In Vivo: Potential for Midmyocardial Salvage in Acute Ischemia. Circ Cardiovasc Imaging. 2009;2(6):460-467 - PMID: 19920044 - PMCID: PMC2780438 - DOI: 10.1161/CIRCIMAGING.109.859678

  • Sosnovik DE, Nahrendorf M, Panizzi P, Matsui T, Aikawa E, Dai G, Li L, Reynolds F, Dorn GW, Weissleder R, Josephson L, Rosenzweig A Molecular MRI Detects Low Levels of Cardiomyocyte Apoptosis in a Transgenic Model of Chronic Heart Failure. Circ Cardiovasc Imaging. 2009;2(6):468-475 - PMID: 19920045 - PMCID: PMC2782621 - DOI: 10.1161/CIRCIMAGING.109.863779

  • Smith RA, Yuan H, Weissleder R, Cantley LC, Josephson L A Wortmannin-Cetuximab as a Double Drug. Bioconjug Chem. 2009;20 :2185-2189 - PMID: 19883074 - PMCID: PMC3386608 - DOI: 10.1021/bc900176a

  • Nahrendorf M, Keliher E, Panizzi P, Zhang H, Hembrador S, Figueiredo JL, Aikawa E, Kelly K, Libby P, Weissleder R 18F-4V for PET-CT Imaging of VCAM-1 Expression in Atherosclerosis. J Am Coll Cardiol Img. 2009;2:1213-1222 - PMID: 19833312 - PMCID: PMC2773129 - DOI: 10.1016/j.jcmg.2009.04.016

  • Panizzi P, Nahrendorf M, Wildgruber M, Waterman P, Figueiredo JL, Aikawa E, McCarthy J, Weissleder R, Hilderbrand SA Oxazine Conjugated Nanoparticle Detects in Vivo Hypochlorous Acid and Peroxynitrite Generation. J Am Chem Soc. 2009;131(43):15739-44 - PMID: 19817443 - PMCID: PMC2773134 - DOI: 10.1021/ja903922u

  • Duchrow T, Shtatland T, Guettler D, Pivovarov M, Kramer S, Weissleder R Enhancing navigation in biomedical databases by community voting and database-driven text classification. BMC Bioinformatics. 2009;10(1):317 - PMID: 19799796 - PMCID: PMC2768718 - DOI: 10.1186/1471-2105-10-317

  • Vinegoni C, Razansky D, Hilderbrand SA, Shao F, Ntziachristos V, Weissleder R Transillumination fluorescence imaging in mice using biocompatible upconverting nanoparticles. Opt Lett. 2009;34(17):2566-8 - PMID: 19724491 - PMCID: PMC2749971 - DOI: 10.1364/OL.34.002566

  • Vinegoni C, Razansky D, Pitsouli C, Perrimon N, Ntziachristos V, Weissleder R Mesoscopic fluorescence tomography for in-vivo imaging of developing Drosophila. J Vis Exp. 2009;(30):pii:1510 - PMID: 19696720 - PMCID: PMC2736679 - DOI: 10.3791/1510

  • Devaraj NK, Upadhyay R, Haun JB, Hilderbrand SA, Weissleder R Fast and Sensitive Pretargeted Labeling of Cancer Cells through a Tetrazine/trans-Cyclooctene Cycloaddition. Angew Chem Int Ed Engl. 2009;48(38):7013-6 - PMID: 19697389 - PMCID: PMC2790075 - DOI: 10.1002/anie.200903233

  • McCarthy JR, Bhaumik J, Merbouh N, Weissleder R High-yielding syntheses of hydrophilic conjugatable chlorins and bacteriochlorins. Org Biomol Chem. 2009;7(17):3430-6 - PMID: 19675897 - PMCID: PMC2749955 - DOI: 10.1039/b908713c

  • Ronald JA*, Chen JW*, Chen Y, Hamilton AM, Rodriguez E, Reynolds F, Hegele RA, Rogers KA, Querol M, Bogdanov A, Weissleder R, Rutt BK Enzyme-Sensitive Magnetic Resonance Imaging Targeting Myeloperoxidase Identifies Active Inflammation in Experimental Rabbit Atherosclerotic Plaques. Circulation. 2009;120(7):592-9 - PMID: 19652086 - PMCID: PMC2736635 - DOI: 10.1161/CIRCULATIONAHA.108.813998

  • Stangenberg L, Ellson C, Cortez-Retamozo V, Ortiz-Lopez A, Yuan H, Blois J, Smith RA, Yaffe MB, Weissleder R, Benoist C, Mathis D, Josephson L, Mahmood U Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function. Arthritis Rheum. 2009;60:2314-2324 - PMID: 19644878 - PMCID: PMC3080016 - DOI: 10.1002/art.24704

  • Swirski* FK, Nahrendorf* M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites. Science. 2009;325 (5940):612-6 - PMID: 19644120 - PMCID: PMC2803111 - DOI: 10.1126/science.1175202

  • Lee H*, Yoon TJ*, Figueiredo JL, Swirski FK, Weissleder R Rapid detection and profiling of cancer cells in fine-needle aspirates. Proc Natl Acad Sci U S A. 2009;106 (30):12459-12464 - PMID: 19620715 - PMCID: PMC2718371 - DOI: 10.1073/pnas.0902365106

  • Bhaumik J, Weissleder R, McCarthy JR Synthesis and Photophysical Properties of Sulfonamidophenyl Porphyrins as Models for Activatable Photosensitizers. J Org Chem. 2009;74(16):5894-901 - PMID: 19610602 - PMCID: PMC2888918 - DOI: 10.1021/jo900832y

  • Nahrendorf M, Waterman P, Thurber G, Groves K, Rajopadhye M, Panizzi P, Marinelli B, Aikawa E, Pittet MJ, Swirski FK, Weissleder R Hybrid In Vivo FMT-CT Imaging of Protease Activity in Atherosclerosis With Customized Nanosensors. Arterioscler Thromb Vasc Biol. 2009;29(10):1444-51 - PMID: 19608968 - PMCID: PMC2746251 - DOI: 10.1161/ATVBAHA.109.193086

  • Garanger E, Hilderbrand SA, Blois JT, Sosnovik DE, Weissleder R, Josephson L A DNA-binding Gd chelate for the detection of cell death by MRI. Chem Commun. 2009;(29):4444-6 - PMID: 19597620 - PMCID: PMC2754278 - DOI: 10.1039/b907375b

  • Hilderbrand SA, Shao F, Salthouse C, Mahmood U, Weissleder R Upconverting luminescent nanomaterials: application to in vivo bioimaging. Chem Commun. 2009;28:4188-90 - PMID: 19585016 - PMCID: PMC2748243 - DOI: 10.1039/b905927j

  • Rajendran R*, Ronald JA*, Ye T, Minqin R, Chen JW, Weissleder R, Rutt BK, Halliwell B, Watt F Nuclear Microscopy: A Novel Technique for Quantitative Imaging of Gadolinium Distribution within Tissue Sections. Microsc Micoranal. 2009;15:338-44 - PMID: 19575834 - PMCID: PMC2802450 - DOI: 10.1017/S1431927609090813

  • Ross RW, Zietman AL, Xie W, Coen JJ, Dahl DM, Shipley WU, Kaufman DS, Islam T, Guimaraes AR, Weissleder R, Harisinghani M Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy. Clin Imaging. 2009;33(4):301-5 - PMID: 19559353 - DOI: 10.1016/j.clinimag.2009.01.013

  • Lee H*, Yoon TJ*, Weissleder R Ultrasensitive Detection of Bacteria Using Core-Shell Nanoparticles and an NMR-Filter System. Angew Chem Int Ed Engl. 2009;48(31):5657-60 - PMID: 19554581 - PMCID: PMC2453069 - DOI: 10.1002/anie.200901791

  • Yoon SS, Stangenberg L, Lee YJ, Rothrock C, Dreyfuss JM, Baek KH, Waterman PR, Nielsen GP, Weissleder R, Mahmood U, Park PJ, Jacks T, Dodd RD, Fisher CJ, Ryeom S, Kirsch DG Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma. Int J Radiat Oncol Biol Phys. 2009;74(4):1207-16 - PMID: 19545786 - PMCID: PMC2733223 - DOI: 10.1016/j.ijrobp.2009.02.052

  • Vonken EJ, Korosoglou G, Yu J, Schar M, Weissleder R, Stuber M On the dual contrast enhancement mechanism in frequency-selective inversion-recovery magnetic resonance angiography (IRON-MRA). Magn Reson Med. 2009;62(2):314-24 - PMID: 19526511 - PMCID: PMC2742771 - DOI: 10.1002/mrm.22027

  • Yuan H, Pupo MT, Blois J, Smith A, Weissleder R, Clardy J, Josephson L A stabilized demethoxyviridin derivative inhibits PI3 kinase. Bioorg Med Chem Lett. 2009;19(15):4223-7 - PMID: 19523825 - PMCID: PMC2877487 - DOI: 10.1016/j.bmcl.2009.05.105

  • Smith A, Blois J, Yuan H, Aikawa E, Ellson C, Figueiredo JL, Weissleder R, Kohler R, Yaffe MB, Cantley LC, Josephson L The antiproliferative cytostatic effects of a self-activating viridin prodrug. Mol Cancer Ther. 2009;8(6):1666-1675 - PMID: 19509266 - PMCID: PMC2740925 - DOI: 10.1158/1535-7163.MCT-08-1012

  • McCarthy JR, Patel P, Botnaru I, Haghayeghi P, Weissleder R, Jaffer FA Multimodal Nanoagents for the Detection of Intravascular Thrombi. Bioconjug Chem. 2009;20(6):1251-5 - PMID: 19456115 - PMCID: PMC2733224 - DOI: 10.1021/bc9001163

  • Figueiredo JL, Nahrendorf M, Sosnovik DE, Weissleder R MRI of a Novel Murine Working Heart Transplant Model. Circ Heart Fail. 2009;2:272-274 - PMID: 19718275 - PMCID: PMC2733535 - DOI: 10.1161/CIRCHEARTFAILURE.109.852707

  • Daniel KD, Kim GY, Vassiliou CC, Galindo M, Guimaraes AR, Weissleder R, Charest A, Langer R, Cima MJ Implantable diagnostic device for cancer monitoring. Biosens Bioelectron. 2009;24(11):3252-7 - PMID: 19442510 - PMCID: PMC2738970 - DOI: 10.1016/j.bios.2009.04.010

  • Wildgruber M, Lee H, Chudnovskiy A, Yoon T, Etzrodt M, Pittet M, Nahrendorf M, Croce K, Libby P, Weissleder R, Swirski F Monocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensors. PLoS ONE. 2009;4(5):e5663 - PMID: 19461894 - PMCID: PMC2680949 - DOI: 10.1371/journal.pone.0005663

  • Vinegoni C, Razansky D, Figueiredo JL, Fexon L, Pivovarov M, Nahrendorf M, Ntziachristos V, Weissleder R Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging. J Vis Exp. 2009;28:1389 - PMID: 19578329 - PMCID: PMC2794886 - DOI: 10.3791/1389

  • Sun N, Liu Y, Lee H, Weissleder R, Ham D CMOS RF Biosensor Utilizing Nuclear Magnetic Resonance. IEEE J Solid-ST Circ. 2009;44:1629-1643

  • Bullain SS, Sahin A, Szentirmai O, Sanchez C, Lin N, Baratta E, Waterman P, Weissleder R, Mulligan RC, Carter BS Genetically engineered T cells to target EGFRvIII expressing glioblastoma. J Neuro-Oncol. 2009;94(3):373-82 - PMID: 19387557 - PMCID: PMC2730985 - DOI: 10.1007/s11060-009-9889-1

  • Swirski FK, Weissleder R, Pittet MJ Heterogeneous In Vivo Behavior of Monocyte Subsets in Atherosclerosis. Arterioscler Thromb Vasc Biol. 2009;29(10):1424-32 - PMID: 19372462 - PMCID: PMC2746262 - DOI: 10.1161/ATVBAHA.108.180521

  • Jaffer FA, Libby P, Weissleder R Optical and Multimodality Molecular Imaging. Insights Into Atherosclerosis. Arterioscler Thromb Vasc Biol. 2009;29(7):1017-24 - PMID: 19359659 - PMCID: PMC2733228 - DOI: 10.1161/ATVBAHA.108.165530

  • Leimgruber A, Berger C, Cortez-Retamozo V, Etzrodt M, Newton A, Waterman P, Figueiredo JL, Kohler R, Elpek N, Mempel TR, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle. Neoplasia. 2009;11(5):459-468 - PMID: 19412430 - PMCID: PMC2672160 - DOI: 10.1593/neo.09356

  • Christen T*, Nahrendorf M*, Wildgruber M, Swirski FK, Aikawa E, Waterman P, Shimizu K, Weissleder R, Libby P Molecular Imaging of Innate Immune Cell Function in Transplant Rejection. Circulation. 2009;119(14):1925-32 - PMID: 19332470 - PMCID: PMC2676889 - DOI: 10.1161/CIRCULATIONAHA.108.796888

  • Koh I, Hong R, Weissleder R, Josephson L Nanoparticle-Target Interactions Parallel Antibody-Protein Interactions. Anal Chem. 2009;81(9):3618-22 - PMID: 19323458 - PMCID: PMC2690647 - DOI: 10.1021/ac802717c

  • Aikawa E, Aikawa M, Libby P, Figueiredo JL, Rusanescu G, Iwamoto Y, Fukuda D, Kohler RH, Shi GP, Jaffer FA, Weissleder R Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease. Circulation. 2009;119(13):1785-94 - PMID: 19307473 - PMCID: PMC2717745 - DOI: 10.1161/CIRCULATIONAHA.108.827972

  • Sasportas LS, Kasmieh R, Wakimoto H, Hingtgen S, van de Water JA, Mohapatra G, Figueiredo JL, Martuza RL, Weissleder R, Shah K Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy. Proc Natl Acad Sci U S A. 2009;106(12):4822-7 - PMID: 19264968 - PMCID: PMC2660771 - DOI: 10.1073/pnas.0806647106

  • Tannous BA, Christensen AP, Pike L, Wurdinger T, Perry KF, Saydam O, Jacobs AH, Garcia-Anoveros J, Weissleder R, Sena-Esteves M, Corey DP, Breakefield XO Mutant Sodium Channel for Tumor Therapy. Mol Cancer Ther. 2009;17(5):810-9 - PMID: 19259066 - PMCID: PMC2751883 - DOI: 10.1038/mt.2009.33

  • Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, Pfannl R, Bronson RT, Chen JW, Weissleder R, Housman DE, Charest A Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proc Natl Acad Sci U S A. 2009;106(8):2712-6 - PMID: 19196966 - PMCID: PMC2650331 - DOI: 10.1073/pnas.0813314106

  • Vinegoni C, Razansky D, Figueiredo JL, Nahrendorf M, Ntziachristos V, Weissleder R Normalized Born ratio for fluorescence optical projection tomography. Opt Lett. 2009;34(3):319-21 - PMID: 19183644 - PMCID: PMC2771918 - DOI: 10.1364/ol.34.000319

  • Kelly K*, Shaw SY*, Nahrendorf M, Kristoff K, Aikawa E, Schreiber SL, Clemons PA, Weissleder R. Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries. Integr Biol (Camb). 2009;1(4):311-317 - PMID: 20023731 - PMCID: PMC2748356 - DOI: 10.1039/b821775k

  • McCann CM, Waterman P, Figueiredo JL, Aikawa E, Weissleder R, Chen JW Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy. Neuroimage. 2009;45(2):360-9 - PMID: 19154791 - PMCID: PMC2707831 - DOI: 10.1016/j.neuroimage.2008.12.022

  • Devaraj NK*, Keliher EJ*, Thurber GM, Nahrendorf M, Weissleder R (18)F Labeled Nanoparticles for in Vivo PET-CT Imaging. Bioconjug Chem. 2009;20(2):397-401 - PMID: 19138113 - PMCID: PMC2644737 - DOI: 10.1021/bc8004649

  • Sheth RA, Upadhyay R, Stangenberg L, Sheth R, Weissleder R, Mahmood U Improved detection of ovarian cancer metastases by intraoperative quantitative fluorescence protease imaging in a pre-clinical model. Gynecol Oncol. 2009;112(3):616-22 - PMID: 19135233 - PMCID: PMC2664404 - DOI: 10.1016/j.ygyno.2008.11.018

  • Garanger E, Weissleder R, Josephson L A Multifunctional Single-Attachment-Point Reagent for Controlled Protein Biotinylation. Bioconjug Chem. 2009;20(1):170-173 - PMID: 19072220 - PMCID: PMC2692913 - DOI: 10.1021/bc800392t

  • Kozloff KM, Quinti L, Patntirapong S, Hauschka PV, Tung CH, Weissleder R, Mahmood U Non-invasive optical detection of cathepsin K-mediated fluorescence reveals osteoclast activity in vitro and in vivo. Bone. 2009;44:190-198 - PMID: 19007918 - PMCID: PMC2656637 - DOI: 10.1016/j.bone.2008.10.036

  • Salthouse C, Weissleder R, Mahmood U Development of a Time Domain Fluorimeter (TDF) for Fluorescent Lifetime Multiplexing Analysis. 2008;3:204-211

  • Rusanescu G, Weissleder R, Aikawa E Notch signaling in cardiovascular disease and calcification. Curr Cardiol Review. 2008;4(3):148-56 - PMID: 19936191 - PMCID: PMC2780816 - DOI: 10.2174/157340308785160552

  • Salthouse CD, Weissleder R, Mahmood U Development of a Time Domain Fluorimeter for Fluorescent Lifetime Multiplexing Analysis. IEEE T Biomed Circuits Syst. 2008;2(3):204-211 - PMID: 19830273 - PMCID: PMC2760943 - DOI: 10.1109/TBCAS.2008.2003195

  • Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, Bronson R, Chen J, Weissleder R, Housman D, Charest A. Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene function in gliomagenesis. Proc Natl Acad Sci U S A. 2008;:ePub

  • Salthouse C, Hilderbrand S, Weissleder R, Mahmood U Design and demonstration of a small-animal up-conversion imager. Opt Express. 2008;16 (26):21731-7 - PMID: 19104605 - PMCID: PMC2717740 - DOI: 10.1364/oe.16.021731

  • Jeong JH, Wang Z, Guimaraes AS, Ouyang X, Figueiredo JL, Ding Z, Jiang S, Guney I, Kang GH, Shin E, Hahn WC, Loda MF, Abate-Shen C, Weissleder R, Chin L BRAF activation initiates but does not maintain invasive prostate adenocarcinoma. PLoS ONE. 2008;3(12):e3949 - PMID: 19079609 - PMCID: PMC2597248 - DOI: 10.1371/journal.pone.0003949

  • Devaraj N, Weissleder R, Hilderbrand S Tetrazine-Based Cycloadditions: Application to Pretargeted Live Cell Imaging. Bioconjug Chem. 2008;19(12):2297-2299 - PMID: 19053305 - PMCID: PMC2677645 - DOI: 10.1021/bc8004446

  • Shao F, Weissleder R, Hilderbrand SA Monofunctional Carbocyanine Dyes for Bio- and Bioorthogonal Conjugation. Bioconjug Chem. 2008;19(12): :2487-2491 - PMID: 19053316 - PMCID: PMC2656649 - DOI: 10.1021/bc800417b

  • Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y, Chirieac LR, Kaur R, Lightbown A, Simendinger J, Li T, Padera RF, Garcia-Echeverria C, Weissleder R, Mahmood U, Cantley LC, Wong KK Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nature Med. 2008;14(12)::1351-1356 - PMID: 19029981 - PMCID: PMC2683415 - DOI: 10.1038/nm.1890

  • Niedre MJ, de Kleine RH, Aikawa E, Kirsch DG, Weissleder R, Ntziachristos V Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo. Proc Natl Acad Sci U S A. 2008;105(49)::19126-19131 - PMID: 19015534 - PMCID: PMC2614726 - DOI: 10.1073/pnas.0804798105

  • Breckwoldt M*, Chen JW*, Stangenberg L, Aikawa E, Rodriguez E, Qiu S, Moskowitz M, Weissleder R Tracking the Inflammatory Response in Stroke in Vivo by Sensing the Enzyme Myeloperoxidase. Proc Natl Acad Sci U S A. 2008;105 (47):18584-18589 - PMID: 19011099 - PMCID: PMC2587593 - DOI: 10.1073/pnas.0803945105

  • Hingtgen S, Ren X, Terwilliger E, Classon M, Weissleder R, Shah K Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and Temozolomide. Mol Cancer Ther. 2008;7(11):3575-85 - PMID: 19001440 - PMCID: PMC2748233 - DOI: 10.1158/1535-7163.MCT-08-0640

  • Cortez-Retamozo V, Swirski FK, Waterman P, Yuan H, Figueiredo JL, Newton AP, Upadhyay R, Vinegoni C, Kohler R, Blois J, Smith A, Nahrendorf M, Josephson L, Weissleder R, Pittet MJ Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation. J Clin Invest. 2008;118(12):4058-66 - PMID: 19033674 - PMCID: PMC2579705 - DOI: 10.1172/JCI36335

  • Wurdinger T, Tannous BA, Saydam O, Skog J, Grau S, Soutschek J, Weissleder R, Breakefield XO, Krichevsky AM miR-296 Regulates Growth Factor Receptor Overexpression in Angiogenic Endothelial Cells. Cancer Cell. 2008;14(5):382-393 - PMID: 18977327 - PMCID: PMC2597164 - DOI: 10.1016/j.ccr.2008.10.005

  • Guimaraes AR, Rakhlin E, Weissleder R, Thayer SP Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft model. Pancreas. 2008;37(4):440-4 - PMID: 18953259 - PMCID: PMC3806135 - DOI: 10.1097/MPA.0b013e31817c5113

  • Girnun GD, Chen L, Silvaggi J, Drapkin R, Chirieac LR, Padera RF, Upadhyay R, Vafai SB, Weissleder R, Mahmood U, Naseri E, Buckley S, Li D, Force J, McNamara K, Demetri G, Spiegelman BM, Wong KK Regression of drug-resistant lung cancer by the combination of rosiglitazone and Carboplatin. Clin Cancer Res. 2008;14(20):6478-86 - PMID: 18927287 - PMCID: PMC2696122 - DOI: 10.1158/1078-0432.CCR-08-1128

  • Jaffer FA, Vinegoni C, John MC, Aikawa E, Gold HK, Finn AV, Ntziachristos V, Libby P, Weissleder R Real-Time Catheter Molecular Sensing of Inflammation in Proteolytically Active Atherosclerosis. Circulation. 2008;118(18):1802-9 - PMID: 18852366 - PMCID: PMC2729441 - DOI: 10.1161/CIRCULATIONAHA.108.785881

  • Garanger E, Aikawa E, Reynolds F, Weissleder R, Josephson L Simplified syntheses of complex multifunctional nanomaterials. Chem Commun. 2008;39:4792-4 - PMID: 18830495 - PMCID: PMC2692914 - DOI: 10.1039/b809537j

  • Perez JM, Grimm J, Josephson L, Weissleder R Integrated nanosensors to determine levels and functional activity of human telomerase. Neoplasia. 2008;10(10):1066-72 - PMID: 18813356 - PMCID: PMC2546593 - DOI: 10.1593/neo.08350

  • Korosoglou G, Shah S, Vonken EJ, Gilson WD, Schar M, Tang L, Kraitchman DL, Boston RC, Sosnovik DE, Weiss RG, Weissleder R, Stuber M Off-Resonance Angiography: A New Method to Depict Vessels--Phantom and Rabbit Studies. Radiology. 2008;249(2)::501-509 - PMID: 18780823 - PMCID: PMC2657865 - DOI: 10.1148/radiol.2491071706

  • Gounaris E, Tung CH, Restaino C, Maehr R, Kohler R, Joyce JA, Plough HL, Barrett TA, Weissleder R, Khazaie K Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. PLoS ONE. 2008;3:e2916 - PMID: 18698347 - PMCID: PMC2488397 - DOI: 10.1371/journal.pone.0002916

  • Korosoglou G, Weiss RG, Kedziorek DA, Walczak P, Gilson WD, Schar M, Sosnovik DE, Kraitchman DL, Boston RC, Bulte JW, Weissleder R, Stuber M Noninvasive detection of macrophage-rich atherosclerotic plaque in hyperlipidemic rabbits using positive contrast magnetic resonance imaging. J Am Coll Cardiol. 2008;52:483-91 - PMID: 18672170 - PMCID: PMC2628468 - DOI: 10.1016/j.jacc.2008.03.063

  • Hilderbrand SA, Kelly KA, Niedre M, Weissleder R Near Infrared Fluorescence-Based Bacteriophage Particles for Ratiometric pH Imaging. Bioconjug Chem. 2008;19(8):1635-9 - PMID: 18666791 - PMCID: PMC2705288 - DOI: 10.1021/bc800188p

  • Sosnovik DE, Nahrendorf M, Weissleder R Targeted imaging of myocardial damage. Nat Clin Pract Card. 2008;5 Suppl 2:S63-70 - PMID: 18641609 - PMCID: PMC2597275 - DOI: 10.1038/ncpcardio1115

  • Gee MS, Upadhyay R, Bergquist H, Alencar H, Reynolds F, Maricevich M, Weissleder R, Josephson L, Mahmood U Human Breast Cancer Tumor Models: Molecular Imaging of Drug Susceptibility and Dosing during HER2/neu-targeted Therapy. Radiology. 2008;248(3):925-35 - PMID: 18647846 - PMCID: PMC2798096 - DOI: 10.1148/radiol.2482071496

  • Lin KY, Maricevich M, Bardeesy N, Weissleder R, Mahmood U In vivo quantitative microvasculature phenotype imaging of healthy and malignant tissues using a fiber-optic confocal laser microprobe. Transl Oncol. 2008;1:84-94 - PMID: 18633456 - PMCID: PMC2510813 - DOI: 10.1593/tlo.08118

  • Blois J, Yuan H, Smith A, Pacold ME, Weissleder R, Cantley LC, Josephson L Slow Self-Activation Enhances The Potency of Viridin Prodrugs. J Med Chem. 2008;51(15):4699-707 - PMID: 18630894 - PMCID: PMC2663427 - DOI: 10.1021/jm800374f

  • Lee H, Sun E, Ham D, Weissleder R Chip-NMR biosensor for detection and molecular analysis of cells. Nature Med. 2008;14(8):869-74 - PMID: 18607350 - PMCID: PMC2729055 - DOI: 10.1038/nm.1711

  • Taktak S, Weissleder R, Josephson L Electrode Chemistry Yields a Nanoparticle-Based NMR Sensor for Calcium. Langmuir. 2008;24 (14):7596-7598 - PMID: 18558729 - PMCID: PMC2748273 - DOI: 10.1021/la8006298

  • McCarthy JR, Weissleder R Multifunctional magnetic nanoparticles for targeted imaging and therapy. Adv Drug Deliv Rev. 2008;60:1241-1251 - PMID: 18508157 - PMCID: PMC2583936 - DOI: 10.1016/j.addr.2008.03.014

  • Shaw SY, Westly EC, Pittet MJ, Subramanian A, Schreiber SL, Weissleder R Perturbational profiling of nanomaterial biologic activity. Proc Natl Acad Sci U S A. 2008;105:7387-7392 - PMID: 18492802 - PMCID: PMC2396702 - DOI: 10.1073/pnas.0802878105

  • Shah K, Hingtgen S, Kasmieh R, Figueiredo JL, Garcia-Garcia E, Martinez-Serrano A, Breakefield X, Weissleder R Bimodal viral vectors and in vivo imaging reveal the fate of human neural stem cells in experimental glioma model. J Neurosci. 2008;28:4406-13 - PMID: 18434519 - PMCID: PMC3021321 - DOI: 10.1523/JNEUROSCI.0296-08.2008

  • Korosoglou G, Tang L, Kedziorek D, Cosby K, Gilson WD, Vonken EJ, Schar M, Sosnovik D, Kraitchman DL, Weiss RG, Weissleder R, Stuber M Positive contrast MR-lymphography using inversion recovery with ON-resonant water suppression (IRON). J Magn Reson Imaging. 2008;27(5):1175-1180 - PMID: 18425827 - PMCID: PMC2740932 - DOI: 10.1002/jmri.21337

  • Koh I, Hong R, Weissleder R, Josephson L Sensitive NMR Sensors Detect Antibodies to Influenza. Angew Chem Int Ed Engl. 2008;47(22):4119-4121 - PMID: 18428168 - PMCID: PMC2668198 - DOI: 10.1002/anie.200800069

  • Kelly KA, Bardeesy N, Anbazhagan R, Gurumurthy S, Berger J, Alencar H, Depinho RA, Mahmood U, Weissleder R Targeted Nanoparticles for Imaging Incipient Pancreatic Ductal Adenocarcinoma. PLoS Med. 2008;5(4):e85 - PMID: 18416599 - PMCID: PMC2292750 - DOI: 10.1371/journal.pmed.0050085

  • Kelly KA, Setlur SR, Ross R, Anbazhagan R, Waterman P, Rubin MA, Weissleder R Detection of early prostate cancer using a hepsin-targeted imaging agent. Cancer Res. 2008;68(7):2286-91 - PMID: 18381435 - PMCID: PMC2709884 - DOI: 10.1158/0008-5472.CAN-07-1349

  • Weissleder R, Pittet MJ Imaging in the era of molecular oncology. Nature. 2008;452:580-589 - PMID: 18385732 - PMCID: PMC2708079 - DOI: 10.1038/nature06917

  • Nahrendorf M, Sosnovik DE, Weissleder R MR-optical imaging of cardiovascular molecular targets. Basic Res Cardiol. 2008;103:87-94 - PMID: 18324364 - PMCID: PMC2664635 - DOI: 10.1007/s00395-008-0707-2

  • Sosnovik DE, Nahrendorf M, Weissleder R Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications. Basic Res Cardiol. 2008;103(2):122-30 - PMID: 18324368 - PMCID: PMC2597271 - DOI: 10.1007/s00395-008-0710-7

  • Hong R, Cima MJ, Weissleder R, Josephson L Magnetic microparticle aggregation for viscosity determination by MR. Magn Reson Med. 2008;59:515-520 - PMID: 18306403 - PMCID: PMC2740908 - DOI: 10.1002/mrm.21526

  • Figueiredo JL, Passerotti CC, Sponholtz T, Nguyen HT, Weissleder R A Novel Method of Imaging Calcium Urolithiasis Using Fluorescence. J Urolology. 2008;179:1610-1614 - PMID: 18295253 - DOI: 10.1016/j.juro.2007.11.100

  • Guimaraes AR, Tabatabei S, Dahl D, McDougal WS, Weissleder R, Harisinghani MG Pilot Study Evaluating Use of Lymphotrophic Nanoparticle-Enhanced Magnetic Resonance Imaging for Assessing Lymph Nodes in Renal Cell Cancer. Urology. 2008;71(4):708-12 - PMID: 18295316 - DOI: 10.1016/j.urology.2007.11.096

  • Nahrendorf M, Aikawa E, Figueiredo JL, Stangenberg L, van den Borne S, Blankesteijn M, Sosnovik D, Jaffer F, Tung CH, Weissleder R Transglutaminase activity in acute infarcts predicts healing outcome and let ventricular remodelling : implications for FXIII therapy and antithrombin use in myocardial infarction. Eur Heart J. 2008;29:445-454 - PMID: 18276618 - DOI: 10.1093/eurheartj/ehm558

  • Nahrendorf M*, Sosnovik D*, Chen JW, Panizzi P, Figueiredo JL, Aikawa E, Libby P, Swirski FK, Weissleder R Activatable Magnetic Resonance Imaging Agent Reports Myeloperoxidase Activity in Healing Infarcts and Noninvasively Detects the Antiinflammatory Effects of Atorvastatin on Ischemia-Reperfusion Injury. Circulation. 2008;117(9):1153-60 - PMID: 18268141 - PMCID: PMC2673051 - DOI: 10.1161/CIRCULATIONAHA.107.756510

  • Chen JW, Breckwoldt MO, Aikawa E, Chiang G, Weissleder R Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis. Brain. 2008;131(Pt 4):1123-33 - PMID: 18234693 - PMCID: PMC4044727 - DOI: 10.1093/brain/awn004

  • Wurdinger T, Badr C, Pike L, de Kleine R, Weissleder R, Breakefield XO, Tannous BA A secreted luciferase for ex vivo monitoring of in vivo processes. Nat Methods. 2008;5:171-173 - PMID: 18204457 - PMCID: PMC2699561 - DOI: 10.1038/nmeth.1177

  • Kircher M, Grimm J, Swirski FK, Libby P, Gerszten R, Allport J, Weissleder R Noninvasive in vivo imaging of monocyte trafficking to atherosclerotic lesions. Circulation. 2008;117:388-395 - PMID: 18172031 - PMCID: PMC2705289 - DOI: 10.1161/CIRCULATIONAHA.107.719765

  • Korngold EC, Jaffer FA, Weissleder R, Sosnovik DE Noninvasive imaging of apoptosis in cardiovascular disease. Heart Fail Rev. 2008;13(2)::163-173 - PMID: 18074226 - PMCID: PMC2597223 - DOI: 10.1007/s10741-007-9068-4

  • Barnes KR, Blois J, Smith A, Yuan H, Reynolds F, Weissleder R, Cantley LC, Josephson L Fate of a Bioactive Fluorescent Wortmannin Derivative in Cells. Bioconjug Chem. 2008;19:130-137 - PMID: 17988080 - DOI: 10.1021/bc7002204

  • Nahrendorf M, Zhang H, Hembrador S, Panizzi P, Sosnovik D, Aikawa E, Libby P, Swirski F, Weissleder R. Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis. Circulation. 2008;117:379-387 - PMID: 18158358 - PMCID: PMC2663426 - DOI: 10.1161/CIRCULATIONAHA.107.741181

  • Hilderbrand SA, Weissleder R One-Pot Synthesis of New Symmetric and Asymmetric Xanthene Dyes. Tetrahedron Lett. 2007;48(25):4383-4385 - PMID: 19834587 - PMCID: PMC2761723 - DOI: 10.1016/j.tetlet.2007.04.088

  • Gounaris E, Erdman SE, Restaino C, Gurish MF, Friend DS, Gounari F, Lee DM, Zhang G, Glickman JN, Shin K, Rao VP, Poutahidis T, Weissleder R, McNagny KM, Khazaie K Mast cells are an essential hematopoietic component for polyp development. Proc Natl Acad Sci U S A. 2007;104:19977-82 - PMID: 18077429 - PMCID: PMC2148408 - DOI: 10.1073/pnas.0704620104

  • Harisinghani M, Ross R, Guimaraes A, Weissleder R Utility of a New Bolus-Injectable Nanoparticle for Clinical Cancer Staging. Neoplasia. 2007;(9)12:1160-1165 - PMID: 18084623 - PMCID: PMC2134912 - DOI: 10.1593/neo.07940

  • Kurozumi K, Hardcastle J, Thakur R, Yang M, Christoforidis G, Fulci G, Hochberg F, Weissleder R, Carson W, Chiocca A, Kaur B. Effect of Tumor Microenvironment Modulation on the Efficacy of Oncolytic Virus Therapy. J Natl Cancer I. 2007;(99) 23:1768-1781 - PMID: 18042934 - DOI: 10.1093/jnci/djm229

  • Shepherd J, Hilderbrand SA, Waterman P, Heinecke JW, Weissleder R, Libby P A fluorescent probe for the detection of myeloperoxidase activity in atherosclerosis-associated macrophages. Chem Biol. 2007;14:1221-31 - PMID: 18022561 - PMCID: PMC2785040 - DOI: 10.1016/j.chembiol.2007.10.005

  • Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med. 2007;204(12):3037-47 - PMID: 18025128 - PMCID: PMC2118517 - DOI: 10.1084/jem.20070885

  • Taktak S, Sosnovik D, Cima MJ, Weissleder R, Josephson L Multiparameter Magnetic Relaxation Switch Assays. Anal Chem. 2007;(79) 23:8863-9 - PMID: 17983206 - DOI: 10.1021/ac701976p

  • Swirski FK, Berger CR, Figueiredo JL, Mempel TR, von Andrian UH, Pittet MJ, Weissleder R A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses. PLoS ONE. 2007;2(10):e1075 - PMID: 17957257 - PMCID: PMC2034600 - DOI: 10.1371/journal.pone.0001075

  • Upadhyay R, Sheth RA, Weissleder R, Mahmood U Quantitative Real-time Catheter-based Fluorescence Molecular Imaging in Mice. Radiology. 2007;245(2):523-31 - PMID: 17940307 - DOI: 10.1148/radiol.2452061613

  • Law B, Weissleder R, Tung CH Protease-Sensitive Fluorescent Nanofibers. Bioconjug Chem. 2007;(18) 6 ::1701-1704 - PMID: 17915958 - PMCID: PMC2528070 - DOI: 10.1021/bc070054z

  • Fulci G, Dmitrieva N, Gianni D, Fontana EJ, Pan X, Lu Y, Kaufman CS, Kaur B, Lawler SE, Lee RJ, Marsh CB, Brat DJ, van Rooijen N, Rachamimov AS, Hochberg FH, Weissleder R, Martuza RL, Chiocca EA Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses. Cancer Res. 2007;67(19):9398-406 - PMID: 17909049 - PMCID: PMC2850558 - DOI: 10.1158/0008-5472.CAN-07-1063

  • Corsten MF, Miranda R, Kasmieh R, Krichevsky AM, Weissleder R, Shah K MicroRNA-21 Knockdown Disrupts Glioma Growth In vivo and Displays Synergistic Cytotoxicity with Neural Precursor Cell Delivered S-TRAIL in Human Gliomas. Cancer Res. 2007;67(19):8994-9000 - PMID: 17908999 - DOI: 10.1158/0008-5472.CAN-07-1045

  • Aikawa E, Nahrendorf M, Figueiredo JL, Swirski F, Shtatland T, Kohler RH, Jaffer F, Aikawa M, Weissleder R. Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo. . Circulation. 2007;116(24):2841-50 - PMID: 18040026 - DOI: 10.1161/CIRCULATIONAHA.107.732867

  • Jaffer FA, Libby P, Weissleder R Molecular imaging of cardiovascular disease. Circulation. 2007;116(9):1052-61 - PMID: 17724271 - DOI: 10.1161/CIRCULATIONAHA.106.647164

  • Tam JM, Upadhyay R, Pittet MJ, Weissleder R, Mahmood U Improved in vivo whole-animal detection limits of green fluorescent protein-expressing tumor lines by spectral fluorescence imaging. Mol Imaging. 2007;6(4):269-76 - PMID: 17711782

  • Gee MS, Upadhyay R, Bergquist H, Weissleder R, Josephson L, Mahmood U Multiparameter noninvasive assessment of treatment susceptibility, drug target inhibition and tumor response guides cancer treatment. Int J Cancer. 2007;(121) 11:2492-2500 - PMID: 17683072 - DOI: 10.1002/ijc.22995

  • Shtatland T, Guettler D, Kossodo M, Pivovarov M, Weissleder R PepBank - a database of peptides based on sequence text mining and public peptide data sources. BMC Bioinformatics. 2007;8(1):280 - PMID: 17678535 - PMCID: PMC1976427 - DOI: 10.1186/1471-2105-8-280

  • Kirsch DG, Dinulescu DM, Miller JB, Grimm J, Santiago PM, Young NP, Nielsen GP, Quade BJ, Chaber CJ, Schultz CP, Takeuchi O, Bronson RT, Crowley D, Korsmeyer SJ, Yoon SS, Hornicek FJ, Weissleder R, Jacks T A spatially and temporally restricted mouse model of soft tissue sarcoma. Nature Med. 2007;13(8):992-997 - PMID: 17676052 - DOI: 10.1038/nm1602

  • Arwert E, Hingtgen S, Figueiredo JL, Bergquist H, Mahmood U, Weissleder R, Shah K. Visualizing the dynamics of EGFR activity and antiglioma therapies in vivo. Cancer Res. 2007;67 (15):7335-7342 - PMID: 17671203 - DOI: 10.1158/0008-5472.CAN-07-0077

  • Kim Y, Choi Y, Weissleder R, Tung CH Membrane permeable esterase-activated fluorescent imaging probe. Bioorg Med Chem Lett. 2007;17(18):5054-7 - PMID: 17664067 - PMCID: PMC1995663 - DOI: 10.1016/j.bmcl.2007.07.026

  • Kelly KA, Carson J, McCarthy JR, Weissleder R Novel Peptide Sequence ("IQ-tag") with High Affinity for NIR Fluorochromes Allows Protein and Cell Specific Labeling for In Vivo Imaging. PLoS ONE. 2007;2:e665 - PMID: 17653285 - PMCID: PMC1919420 - DOI: 10.1371/journal.pone.0000665

  • Wu HJ, Sawaya H, Binstadt B, Brickelmaier M, Blasius A, Gorelik L, Mahmood U, Weissleder R, Carulli J, Benoist C, Mathis D. Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk. J Exp Med. 2007;204:1911-1922 - PMID: 17646407 - PMCID: PMC2118664 - DOI: 10.1084/jem.20070285

  • Pittet M, Grimm J, Berger C, Tamura T, Wojtkiewicz G, Nahrendorf M, Romero P, Swirski F, Weissleder R. In vivo imaging of T cell delivery to tumors after adoptive transfer therapy. Proc Natl Acad Sci U S A. 2007;104:12457-12461 - PMID: 17640914 - PMCID: PMC1941490 - DOI: 10.1073/pnas.0704460104

  • Sosnovik DE, Weissleder R Emerging concepts in molecular MRI. Curr Opin Biotech. 2007;18(1):4-10 - PMID: 17126545 - DOI: 10.1016/j.copbio.2006.11.001

  • Kock N, Kasmieh R, Weissleder R, Shah K Tumor Therapy Mediated by Lentiviral Expression of shBcl-2 and S-TRAIL. Neoplasia. 2007;9(5):435-42 - PMID: 17534449 - PMCID: PMC1877976 - DOI: 10.1593/neo.07223

  • Kim YM, Hilderbrand S, Weissleder R, Tung CH Sugar sensing based on induced pH changes. Chem Commun. 2007;(22):2299-2301 - PMID: 17534523 - DOI: 10.1039/b700741h

  • Sheth RA, Upadhyay R, Weissleder R, Mahmood U Real-time multichannel imaging framework for endoscopy, catheters, and fixed geometry intraoperative systems. Mol Imaging. 2007;6(3):147-55 - PMID: 17532881

  • Alencar H, Funovics MA, Figueiredo J, Sawaya H, Weissleder R, Mahmood U Colonic Adenocarcinomas: Near-Infrared Microcatheter Imaging of Smart Probes for Early Detection. Radiology. 2007;244(1):232-8 - PMID: 17507718 - DOI: 10.1148/radiol.2441052114

  • Kozloff KM, Weissleder R, Mahmood U Non-Invasive Optical Detection of Bone Mineral. J Bone Miner Res. 2007;(22) 8:1208-1216 - PMID: 17488196 - DOI: 10.1359/jbmr.070504

  • Sosnovik DE, Nahrendorf M, Weissleder R Molecular magnetic resonance imaging in cardiovascular medicine. Circulation. 2007;115(15):2076-86 - PMID: 17438163 - DOI: 10.1161/CIRCULATIONAHA.106.658930

  • Jaffer FA, Kim DE, Quinti L, Tung CH, Aikawa E, Pande AN, Kohler RH, Shi GP, Libby P, Weissleder R Optical Visualization of Cathepsin K Activity in Atherosclerosis With a Novel, Protease-Activatable Fluorescence Sensor. Circulation. 2007;115(17):2292-8 - PMID: 17420353 - DOI: 10.1161/CIRCULATIONAHA.106.660340

  • Hilderbrand S, Weissleder R. Optimized pH-responsive cyanine fluorochromes for detection of acidic environments. Chem Commun. 2007;(26):2747-9 - PMID: 17594041 - DOI: 10.1039/b703764c

  • McCarthy J, Kelly KA, Sun EY, Weissleder R. Targeted delivery of multifunctional magnetic nanoparticles. Nanomedicine. 2007;2(2):153-167 - PMID: 17716118 - DOI: 10.2217/17435889.2.2.153

  • Yuan H, Barnes KR, Weissleder R, Cantley L, Josephson L Covalent Reactions of Wortmannin under Physiological Conditions. Chem Biol. 2007;14(3):321-8 - PMID: 17379147 - DOI: 10.1016/j.chembiol.2007.02.007

  • Nahrendorf M, Sosnovik D, Waterman P, Swirski F, Pande A, Aikawa E, Figueiredo JL, Pittet M, Weissleder R. Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct. Circ Res. 2007;100:1218-1225 - PMID: 17379832 - DOI: 10.1161/01.RES.0000265064.46075.31

  • Sosnovik DE, Nahrendorf M, Deliolanis N, Novikov M, Aikawa E, Josephson L, Rosenzweig A, Weissleder R, Ntziachristos V Fluorescence Tomography and Magnetic Resonance Imaging of Myocardial Macrophage Infiltration in Infarcted Myocardium In Vivo. Circulation. 2007;115:1384-1391 - PMID: 17339546 - DOI: 10.1161/CIRCULATIONAHA.106.663351

  • Nahrendorf M, Badea C, Hedlund LW, Figueiredo JL, Sosnovik DE, Johnson GA, Weissleder R High Resolution Imaging of Murine Myocardial Infarction With Delayed Enhancement Cine Micro-CT. Am J Physiol-Heart C. 2007;292(6):3172-8 - PMID: 17322414 - PMCID: PMC2680216 - DOI: 10.1152/ajpheart.01307.2006

  • Montet X, Figueiredo JL, Alencar H, Ntziachristos V, Mahmood U, Weissleder R. Tomographic fluorescence imaging of tumor vascular volume in mice. Radiology. 2007;242 (3):751-758 - PMID: 17325064 - DOI: 10.1148/radiol.2423052065

  • Montet-Abou K, Montet X, Weissleder R, Josephson L Cell internalization of magnetic nanoparticles using transfection agents. Mol Imaging. 2007;(6) 1:1-9 - PMID: 17311760

  • Ho NH, Weissleder R, Tung CH A Self-Immolative Reporter For beta-Galactosidase Sensing. Chembiochem. 2007;8:560-566 - PMID: 17300128 - DOI: 10.1002/cbic.200600386

  • Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T Restoration of p53 function leads to tumour regression in vivo. Nature. 2007;445:661-5 - PMID: 17251932 - DOI: 10.1038/nature05541

  • McCarthy JR, Weissleder R Model Systems for Fluorescence and Singlet Oxygen Quenching by Metalloporphyrins. ChemMedChem. 2007;2:360-365 - PMID: 17245681 - DOI: 10.1002/cmdc.200600244

  • Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R Multimodality Molecular Imaging Identifies Proteolytic and Osteogenic Activities in Early Aortic Valve Disease. Circulation. 2007;115:377-386 - PMID: 17224478 - DOI: 10.1161/CIRCULATIONAHA.106.654913

  • Swirski FK, Libby P, Aikawa E, Alcaide P, Luscinskas FW, Weissleder R, Pittet MJ Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest. 2007;117(1):195-205 - PMID: 17200719 - PMCID: PMC1716211 - DOI: 10.1172/JCI29950

  • Izmailova ES, Paz N, Alencar H, Chun M, Schopf L, Hepperle M, Lane JH, Harriman G, Xu Y, Ocain T, Weissleder R, Mahmood U, Healy AM, Jaffee B Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis. Arth Rheum/AR C Res. 2007;56(1):117-128 - PMID: 17195214 - DOI: 10.1002/art.22303

  • Grimm J, Kircher MF, Weissleder R Cell tracking : Principles and applications. Radiologe. 2007;47(1):25-33 - PMID: 17187264 - DOI: 10.1007/s00117-006-1449-5

  • Nahrendorf M, Weissleder R Advances in cardiovascular medicine through molecular imaging. Radiologe. 2007;47(1):18-24 - PMID: 17187263 - DOI: 10.1007/s00117-006-1450-z

  • Nahrendorf M, Weissleder R, Ertl G Does FXIII Deficiency Impair Wound Healing after Myocardial Infarction?. PLoS ONE. 2006;1:e48 - PMID: 17183677 - PMCID: PMC1762326 - DOI: 10.1371/journal.pone.0000048

  • Kelly KA, Waterman P, Weissleder R. In vivo imaging of molecularly targeted phage. Neoplasia. 2006;8 (12):1011-1018

  • Kim DE, Tsuji K, Kim YR, Mueller FJ, Eom HS, Snyder EY, Lo EH, Weissleder R, Schellingerhout D Neural Stem Cell Transplant Survival in Brains of Mice: Assessing the Effect of Immunity and Ischemia by using Real-time Bioluminescent Imaging. Radiology. 2006;241(3):822-830 - PMID: 17114629 - DOI: 10.1148/radiol.2413050466

  • Saksena M, Harisinghani M, Hahn P, Kim J, Saokar A, King B, Weissleder R Comparison of lymphotropic nanoparticle-enhanced MRI sequences in patients with various primary cancers. AJR Am J Roentgenol. 2006;187(6):W582-8 - PMID: 17114509 - DOI: 10.2214/AJR.05.0873

  • Campanella GS, Grimm J, Manice LA, Colvin RA, Medoff BD, Wojtkiewicz GR, Weissleder R, Luster AD Oligomerization of CXCL10 Is Necessary for Endothelial Cell Presentation and In Vivo Activity. J Immunol. 2006;177:6991-8 - PMID: 17082614 - DOI: 10.4049/jimmunol.177.10.6991

  • Jaffer FA, Sosnovik DE, Nahrendorf M, Weissleder R Molecular imaging of myocardial infarction. J Mol Cell Cardiol. 2006;41:921-933 - PMID: 17067633 - DOI: 10.1016/j.yjmcc.2006.09.008

  • Lamfers ML, Fulci G, Gianni D, Tang Y, Kurozumi K, Kaur B, Moeniralm S, Saeki Y, Carette JE, Weissleder R, Vandertop WP, van Beusechem VW, Dirven CM, Chiocca EA Cyclophosphamide Increases Transgene Expression Mediated by an Oncolytic Adenovirus in Glioma-Bearing Mice Monitored by Bioluminescence Imaging. Mol Ther. 2006;4(6):779-88 - PMID: 16996314 - PMCID: PMC2819149 - DOI: 10.1016/j.ymthe.2006.08.008

  • Choi Y, Weissleder R, Tung CH Protease-mediated phototoxicity of a polylysine-chlorin(E6) conjugate. ChemMedChem. 2006;1:698-701 - PMID: 16902920 - DOI: 10.1002/cmdc.200600053

  • Funovics MA, Alencar H, Montet X, Weissleder R, Mahmood U Simultaneous fluorescence imaging of protease expression and vascularity during murine colonoscopy for colonic lesion characterization. Gastrointest Endosc. 2006;64(4):589-97 - PMID: 16996355 - DOI: 10.1016/j.gie.2006.02.048

  • Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby P, Weissleder R Noninvasive Vascular Cell Adhesion Molecule-1 Imaging Identifies Inflammatory Activation of Cells in Atherosclerosis. Circulation. 2006;114:1504-1511 - PMID: 17000904 - DOI: 10.1161/CIRCULATIONAHA.106.646380

  • Montet X, Funovics M, Montet-Abou K, Weissleder R, Josephson L. Multivalent effects of RGD peptides obtained by nanoparticle display. J Med Chem. 2006;49(20):6087-6093

  • Newton JR, Kelly KA, Mahmood U, Weissleder R, Deutscher SL In vivo selection of phage for the optical imaging of PC-3 human prostate carcinoma in mice. Neoplasia. 2006;8(9):772-80 - PMID: 16984734 - PMCID: PMC1584300 - DOI: 10.1593/neo.06331

  • Hynynen K, McDannold N, Vykhodtseva N, Raymond S, Weissleder R, Jolesz FA, Sheikov N Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery. J Neurosurg. 2006;105:445-54 - PMID: 16961141 - DOI: 10.3171/jns.2006.105.3.445

  • Zacharakis G, Shih H, Ripoll J, Weissleder R, Ntziachristos V Normalized transillumination of fluorescent proteins in small animals. Mol Imaging. 2006;5 (2):153-9 - PMID: 16954030

  • Jaffer F, Nahrendorf M, Sosnovik D, Kelly KA, Aikawa E, Weissleder R Cellular Imaging of Inflammation in Atherosclerosis Using Magnetofluorescent Nanomaterials. Mol Imaging. 2006;(5) 2 :85-92 - PMID: 16954022

  • Law B, Quinti L, Choi YD, Weissleder R, Tung CH A Mitochondrial Targeted Fusion Peptide Exhibits Remarkable Cytotoxicity. Mol Cancer Ther. 2006;5 (8):1944-1949 - PMID: 16928814 - DOI: 10.1158/1535-7163.MCT-05-0509

  • Sun EY, Weissleder R, Josephson L. Continuous Analyte Sensing with Magnetic Nanoswitches. Small. 2006;(2) 10:1144-1147 - PMID: 17193579 - DOI: 10.1002/smll.200600204

  • Sun EY, Josephson L, Weissleder R. Clickable nanoparticles for targeted imaging. Mol Imaging. 2006;(5) 2:122-128 - PMID: 16954026

  • Fulci G, Breymann L,Gianni D, Kurozomi K, Rhee S, Yu J, Kaur B, Louis D, Weissleder R, Caligiuri M, Chiocca A. Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses. Proc Natl Acad Sci U S A. 2006;103:12873-12878 - PMID: 16908838 - PMCID: PMC1568940 - DOI: 10.1073/pnas.0605496103

  • Mempel T, Pittet M, Khazaie K, Weninger W, Weissleder R, von Boehmer H, von Adrian U. Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity. 2006;25(1):129-41 - PMID: 16860762 - DOI: 10.1016/j.immuni.2006.04.015

  • Chen JW, Querol Sans M, Bogdanov Jr A, Weissleder R Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates. Radiology. 2006;240 (2):473-81 - PMID: 16864673 - DOI: 10.1148/radiol.2402050994

  • Galande A, Hilderbrand S, Weissleder R, Tung CH. Enzyme-targeted fluorescent imaging probes on a multiple antigenic peptide core. J Med Chem. 2006;49(15):4715-20 - PMID: 16854078 - DOI: 10.1021/jm051001a

  • Choi YD, Weissleder R, Tung CH. Selective antitumor effect of novel protease-mediated photodynamic agent. Cancer Res. 2006;66 (14):7225-7229 - PMID: 16849570 - DOI: 10.1158/0008-5472.CAN-06-0448

  • Montet X, Weissleder R, Josephson L. Imaging pancreatic cancer with a peptide-nanoparticle conjugate targeted to normal pancreas. Bioconjug Chem. 2006;17(4):905-911 - PMID: 16848396 - DOI: 10.1021/bc060035+

  • McCarthy J, Jaffer F, Weissleder R. A Macrophage Targeted Theranostic Nanoparticle for Biomedical Applications . Small. 2006;2(8-9):983-987 - PMID: 17193154 - DOI: 10.1002/smll.200600139

  • Hsiao JK, Law B, Weissleder R, Tung CH In-vivo imaging of tumor associated urokinase-type plasminogen activator activity. J Biomed Opt. 2006;11(3):34013 - PMID: 16822063 - DOI: 10.1117/1.2204029

  • Deguchi JO, Aikawa M, Tung CH, Aikawa E, Kim DE, Ntziachristos V, Weissleder R, Libby P Inflammation in Atherosclerosis. Visualizing Matrix Metalloproteinase Action in Macrophages In Vivo. Circulation. 2006;114:55-62 - PMID: 16801460 - DOI: 10.1161/CIRCULATIONAHA.106.619056

  • Swirski FK, Pittet MJ, Kircher MF, Aikawa E, Jaffer FA, Libby P, Weissleder R Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease. Proc Natl Acad Sci U S A. 2006;103(27):10340-5 - PMID: 16801531 - PMCID: PMC1502459 - DOI: 10.1073/pnas.0604260103

  • Pittet M, Swirski F, Reynolds F, Josephson L, Weissleder R. Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles. Nat Protoc. 2006;1(1):73-79 - PMID: 17406214 - DOI: 10.1038/nprot.2006.11

  • Ji H, Li D, Chen L, Shimamura T, Kobayashi S, McNamara K, Mahmood U, Mitchell A, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Kim W, Janne PA, Shapiro GI, Tenen D, Johnson BE, Weissleder R, Sharpless NE, Wong KK The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell. 2006;9(6):485-95 - PMID: 16730237 - DOI: 10.1016/j.ccr.2006.04.022

  • Weissleder R. Molecular Imaging in Cancer. Science. 2006;312:1168-1171 - PMID: 16728630 - DOI: 10.1126/science.1125949

  • Deramaudt TB, Takaoka M, Upadhyay R, Bowser MJ, Porter J, Lee A, Rhoades B, Johnstone CN, Weissleder R, Hingorani SR, Mahmood U, Rustgi AK N-Cadherin and Keratinocyte Growth Factor Receptor Mediate the Functional Interplay between Ki-RASG12V and p53V143A in Promoting Pancreatic Cell Migration, Invasion, and Tissue Architecture Disruption. Mol Cell Biol. 2006;26(11):4185-200 - PMID: 16705170 - PMCID: PMC1489079 - DOI: 10.1128/MCB.01055-05

  • Kelly KA, Nahrendorf M, Yu AM, Reynolds F, Weissleder R In Vivo Phage Display Selection Yields Atherosclerotic Plaque Targeted Peptides for Imaging. Mol Imaging Biol. 2006;8(4):201-7 - PMID: 16791746 - DOI: 10.1007/s11307-006-0043-6

  • Pande AN, Kohler RH, Aikawa E, Weissleder R, Jaffer FA Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy. J Biomed Opt. 2006;11(2):21009 - PMID: 16674184 - DOI: 10.1117/1.2186337

  • Kelly KA, Clemons PA, Yu AM, Weissleder R High throughput identification of phage-derived imaging agents. Mol Imaging. 2006;5(1):24-30 - PMID: 16779967

  • Trehin R, Figueiredo JL, Pittet M, Weissleder R, Josephson L, Mahmood U. Fluorescent Nanoparticle Uptake for Brain Tumor Visualization. Neoplasia. 2006;8(4):302-311 - PMID: 16756722 - PMCID: PMC1600680 - DOI: 10.1593/neo.05751

  • Tannous B*, Grimm J*, Perry K, Chen J, Weissleder R, Breakefield X. Metabolic Biotinylation of Cell Surface Receptors for in vivo Imaging. Nat Methods. 2006;3(5):391-396 - PMID: 16628210 - DOI: 10.1038/nmeth875

  • Kang HW, Torres D, Wald L, Weissleder R, Bogdanov AA Targeted imaging of human endothelial-specific marker in a model of adoptive cell transfer. Lab Invest. 2006;86(6):599-609 - PMID: 16607378 - DOI: 10.1038/labinvest.3700421

  • Law B, Weissleder R, Tung CH Peptide-based Biomaterials for Protease-Enhanced Drug Delivery. Biomacromolecules. 2006;7(4):1261-1265 - PMID: 16602747 - DOI: 10.1021/bm050920f

  • Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA Both p16Ink4a and the p19Arf-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A. 2006;103:5947-5952 - PMID: 16585505 - PMCID: PMC1458678 - DOI: 10.1073/pnas.0601273103

  • Jaffer F, Libby P, Weissleder R. Molecular and Cellular Imaging of Atherosclerosis, Emerging Applications. J Am Coll Cardiol. 2006;47:1328-1338 - PMID: 16580517 - DOI: 10.1016/j.jacc.2006.01.029

  • Choi YD, McCarthy J, Weissleder R, Tung CH Conjugation of a Photosensitizer to an Oligoarginine-based Cell-penetrating Peptide Increases the Efficacy of Photodynamic Therapy. ChemMedChem. 2006;1(4):458-463 - PMID: 16892381 - DOI: 10.1002/cmdc.200500036

  • Montet X, Montet-Abou K, Reynolds F, Weissleder R, Josephson L. Nanoparticle Imaging of Integrins on Tumor Cells. Neoplasia. 2006;8(3):214-222 - PMID: 16611415 - PMCID: PMC1578521 - DOI: 10.1593/neo.05769

  • Montet X, Yuan H, Weissleder R, Josephson L Enzyme-based visualization of receptor-ligand binding in tissues. Lab Invest. 2006;86(5):517-25 - PMID: 16568109 - DOI: 10.1038/labinvest.3700404

  • Yen L, Magnier M, Weissleder R, Stockwell BR, Mulligan RC Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA. 2006;12(5):797-806 - PMID: 16556935 - PMCID: PMC1440893 - DOI: 10.1261/rna.2300406

  • Galande A, Weissleder R, Tung CH. Fluorescence Probe with a pH-Sensitive Trigger. Bioconjug Chem. 2006;17 (2):255-257 - PMID: 16536452 - DOI: 10.1021/bc050330e

  • Ho NH, Weissleder R, Tung CH Development of a dual fluorogenic and chromogenic dipeptidyl peptidase IV substrate. Bioorg Med Chem. 2006;16:2599-2602 - PMID: 16517162 - DOI: 10.1016/j.bmcl.2006.02.045

  • Nahrendorf M, Hu K, Frantz S, Jaffer F, Tung CH, Hiller KH, Voll S, Nordbeck P, Sosnovik D, Gattenlohner S, Novikov M, Dickneite G, Reed G, Jakob P, Rosenzweig A, Bauer W, Weissleder R, Ertl G. Factor XIII Deficiency Causes Cardiac Rupture, Impairs Wound Healing, and Aggravates Cardiac Remodeling in Mice with Myocardial Infarction. Circulation. 2006;113(9):1196-1202 - PMID: 16505171 - PMCID: PMC4066325 - DOI: 10.1161/CIRCULATIONAHA.105.602094

  • Vianello F, Papeta N, Chen T, Kraft P, White N, Hart WK, Kircher MF, Swart E, Rhee S, Palu G, Irimia D, Toner M, Weissleder R, Poznansky MC Murine B16 Melanomas Expressing High Levels of the Chemokine Stromal-Derived Factor-1/CXCL12 Induce Tumor-Specific T Cell Chemorepulsion and Escape from Immune Control. J Immunol. 2006;176(5):2902-14 - PMID: 16493048 - DOI: 10.4049/jimmunol.176.5.2902

  • Quinti L, Weissleder R, Tung CH A Fluorescent Nanosensor for Apoptotic Cells. Nano Lett. 2006;6 (3):488-490 - PMID: 16522048 - DOI: 10.1021/nl0524694

  • Binstadt BA, Patel PR, Alencar H, Nigrovic PA, Lee DM, Mahmood U, Weissleder R, Mathis D, Benoist C Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol. 2006;7(3):284-92 - PMID: 16444258 - DOI: 10.1038/ni1306

  • Rabin O, Manuel Perez J, Grimm J, Wojtkiewicz G, Weissleder R An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles. Nat Mater. 2006;5(2):118-22 - PMID: 16444262 - DOI: 10.1038/nmat1571

  • Yuan H, Luo J, Weissleder R, Cantley L, Josephson L Wortmannin-C20 Conjugates Generate Wortmannin. J Med Chem. 2006;49(2):740-747 - PMID: 16420059 - DOI: 10.1021/jm050699p

  • Ho NH, Weissleder R, Tung CH Development of water-soluble far-red fluorogenic dyes for enzyme sensing. Tetrahedron. 2006;62:578-585

  • Banerjee P, Weissleder R, Bogdanov A Linear Polyethyleneimine Grafted to a Hyperbranched Poly(ethylene glycol)-like Core: A Copolymer for Gene Delivery. Bioconjug Chem. 2006;17(1):125-31 - PMID: 16417260 - DOI: 10.1021/bc050083e

  • Sun EY, Josephson L, Kelly KA, Weissleder R Development of nanoparticle libraries for biosensing. Bioconjug Chem. 2006;17(1):109-13 - PMID: 16417258 - DOI: 10.1021/bc050290e

  • Messerli SM, Prabhakar S, Tang Y, Mahmood U, Weissleder R, Bronson R, Martuza R, Rabkin S, Breakefield XO Treatment of schwannomas with an oncolytic recombinant herpes simplex virus in murine models of neurofibromatosis type 2. Hum Gene Ther. 2006;17(1):20-30 - PMID: 16409122 - DOI: 10.1089/hum.2006.17.20

  • Zhang M, Alicot EM, Chiu I, Li J, Verna N, Vorup-Jensen T, Kessler B, Shimaoka M, Chan R, Friend D, Mahmood U, Weissleder R, Moore FD, Carroll MC Identification of the target self-antigens in reperfusion injury. J Exp Med. 2006;203(1):141-152 - PMID: 16390934 - PMCID: PMC2118091 - DOI: 10.1084/jem.20050390

  • Montet X, Rajopadhye M, Weissleder R. An albumin-activated far-red fluorochrome for in vivo imaging. ChemMedChem. 2006;1(1):66-69 - PMID: 16892337 - DOI: 10.1002/cmdc.200500028

  • Harisinghani MG, Saksena MA, Hahn PF, King B, Kim J, Torabi MT, Weissleder R Ferumoxtran-10-Enhanced MR Lymphangiography: Does Contrast-Enhanced Imaging Alone Suffice for Accurate Lymph Node Characterization?. AJR Am J Roentgenol. 2006;186(1):144-8 - PMID: 16357394 - DOI: 10.2214/AJR.04.1287

  • Achilefu S, Contag CH, Savitsky AP, Weissleder R Chemical and Genetic Sensors in Biomedical Research. J Biomed Opt. 2005;10(4):41201 - PMID: 23171967

  • Zacharakis G, Ripoli G, Weissleder R, Ntziachristos V Fluorescent Protein Tomography Scanner for Small Animal Imaging. 2005;(24) 7:878-885

  • Kim CF, Jackson EL, Kirsch DG, Grimm J, Shaw AT, Lane K, Kissil J, Olive KP, Sweet-Cordero A, Weissleder R, Jacks T Mouse Models of Human Non-Small-Cell Lung Cancer: Raising the Bar. Cold Spring Harb Symp Quant Biol. 2005;70:241-250 - PMID: 16869760 - DOI: 10.1101/sqb.2005.70.037

  • Brown AB, Mahmood U, Cortes ML, Tang Y, Dai G, Stemmer-Rachamimov A, Prabhakar S, Leishear K, Onda H, Kwiatkowski D, Weissleder R, Breakefield X Magnetic resonance imaging and characterization of spontaneous lesions in a transgenic mouse model of tuberous sclerosis as a model for endothelial cell-based transgene delivery. Hum Gene Ther. 2005;16:1367-76 - PMID: 16390268 - DOI: 10.1089/hum.2005.16.1367

  • McCarthy JR, Perez JM, Brueckner C, Weissleder R Polymeric Nanoparticle Preparation that Eradicates Tumors. Nano Lett. 2005;5:2552-6 - PMID: 16351214 - DOI: 10.1021/nl0519229

  • Zacharakis G, Kambara H, Shih H, Ripoll J, Grimm J, Saeki Y, Weissleder R, Ntziachristos V. Volumetric tomography of fluorescent proteins through small animals in vivo. Proc Natl Acad Sci U S A. 2005;102:18252-18257 - PMID: 16344470 - PMCID: PMC1317905 - DOI: 10.1073/pnas.0504628102

  • Chen WT, Khazaie K, Zhang G, Weissleder R, Tung CH Detection of dysplastic intestinal adenomas using a fluorescent folate imaging probe. Mol Imaging. 2005;4 (1):67-74 - PMID: 15912902

  • Sosnovik D, Weissleder R Magnetic resonance and fluorescence based molecular imaging technologies. Prog Drug Res. 2005;62:83-115 - PMID: 16329255 - DOI: 10.1007/3-7643-7426-8_3

  • Alencar H, Mahmood U, Kawano Y, Hirata T, Weissleder R Novel Multiwavelength Microscopic Scanner for Mouse Imaging. Neoplasia. 2005;7(11):977-983 - PMID: 16331883 - PMCID: PMC1502018 - DOI: 10.1593/neo.05376

  • Kelloff GJ, Krohn KA, Larson SM, Weissleder R, Mankoff DA, Hoffman JM, Link JM, Guyton KZ, Eckelman WC, Scher HI, O The progress and promise of molecular imaging probes in oncologic drug development. Clin Cancer Res. 2005;11(22):7967-85 - PMID: 16299226 - DOI: 10.1158/1078-0432.CCR-05-1302

  • Querol Sans M*, Chen JW*, Weissleder R, Bogdanov AA Myeloperoxidase Activity Imaging Using (67)Ga Labeled Substrate. Mol Imaging Biol. 2005;:1-8 - PMID: 16292477 - DOI: 10.1007/s11307-005-0020-5

  • Harisinghani MG, Saksena M, Ross RW, Tabatabaei S, Dahl D, McDougal S, Weissleder R A pilot study of lymphotrophic nanoparticle-enhanced magnetic resonance imaging technique in early stage testicular cancer: a new method for noninvasive lymph node evaluation. Urology. 2005;66(5):1066-71 - PMID: 16286125 - DOI: 10.1016/j.urology.2005.05.049

  • Pivovarov M, Bhandary G, Mahmood U, Zahlmann G, Naraghi M, Weissleder R MIPortal: A High Capacity Server for Molecular Imaging Research. Mol Imaging. 2005;4(4):425-31 - PMID: 16285904

  • Shih HA, Harisinghani M, Zietman AL, Wolfgang JA, Saksena M, Weissleder R. Mapping of nodal disease in locally advanced prostate cancer: Rethinking the clinical target volume for pelvic nodal irradiation based on vascular rather than bony anatomy. Int J Radiat Oncol Biol Phys. 2005;63(4):1262-9 - PMID: 16253781 - DOI: 10.1016/j.ijrobp.2005.07.952

  • Funovics M, Montet X, Reynolds F, Weissleder R, Josephson L. Nanoparticles for the Optical Imaging of Tumor E-selectin. Neoplasia. 2005;7(10):904-11 - PMID: 16242073 - DOI: 10.1593/neo.05352

  • Weissleder R, Kelly K, Sun E, Shtatland T, Josephson L. Cell-specific targeting of nanoparticles by multivalent attachment of small molecules. Nat Biotechnol. 2005;23:1418-1423 - PMID: 16244656 - DOI: 10.1038/nbt1159

  • Kim YR, Yudina A, Figueiredo J, Reichardt W, Hu-Lowe D, Petrovsky A, Kang HW, Torres D, Mahmood U, Weissleder R, Bogdanov AA Jr. Detection of Early Antiangiogenic Effects in Human Colon Adenocarcinoma Xenografts: In vivo Changes of Tumor Blood Volume in Response to Experimental VEGFR Tyrosine Kinase Inhibitor. Cancer Res. 2005;65(20):9253-60 - PMID: 16230386 - DOI: 10.1158/0008-5472.CAN-03-2619

  • Reichardt W, Hu-Lowe D, Torres D, Weissleder R, Bogdanov A Jr. Imaging of VEGF receptor kinase inhibitor-induced antiangiogenic effects in drug-resistant human adenocarcinoma model. Neoplasia. 2005;7(9):847-53 - PMID: 16229807 - PMCID: PMC1351316 - DOI: 10.1593/neo.05139

  • Montet-Abou K, Montet X, Weissleder R, Josephson L. Transfection agent induced nanoparticle cell loading. Mol Imaging. 2005;4(3):165-71 - PMID: 16194448

  • Graves EE, Yessayan D, Turner G, Weissleder R, Ntziachristos V. Validation of in vivo fluorochrome concentrations measured using fluorescence molecular tomography. J Biomed Opt. 2005;10(4):44019 - PMID: 16178652 - DOI: 10.1117/1.1993427

  • Grimm J, Kirsch DG, Windsor SD, Kim CF, Santiago PM, Ntziachristos V, Jacks T, Weissleder R. Use of gene expression profiling to direct in vivo molecular imaging of lung cancer. Proc Natl Acad Sci U S A. 2005;102(40):14404-14409 - PMID: 16183744 - PMCID: PMC1242291 - DOI: 10.1073/pnas.0503920102

  • Hilderbrand SA, Kelly KA, Weissleder R, Tung CH. Monofunctional near-infrared fluorochromes for imaging applications. Bioconjug Chem. 2005;16(5):1275-81 - PMID: 16173808 - DOI: 10.1021/bc0501799

  • Reynolds F, Weissleder R, Josephson L. Protamine as an efficient membrane-translocating Peptide. Bioconjug Chem. 2005;16(5):1240-5 - PMID: 16173804 - DOI: 10.1021/bc0501451

  • Tang Y, Kim M, Carrasco D, Kung AL, Chin L, Weissleder R. In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time magnetic resonance imaging. Cancer Res. 2005;65(18):8324-30 - PMID: 16166309 - DOI: 10.1158/0008-5472.CAN-05-0027

  • Turvey SE, Swart E, Denis MC, Mahmood U, Benoist C, Weissleder R, Mathis D. Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes. J Clin Invest. 2005;115(9):2454-2461 - PMID: 16110329 - PMCID: PMC1187933 - DOI: 10.1172/JCI25048

  • Sosnovik DE, Schellenberger EA, Nahrendorf M, Novikov MS, Matsui T, Dai G, Reynolds F, Grazette L, Rosenzweig A, Weissleder R, Josephson L. Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle. Magn Reson Med. 2005;54(3):718-724 - PMID: 16086367 - DOI: 10.1002/mrm.20617

  • Zhu B, Jaffer F, Nztiachristos V, Weissleder R Development of a near infrared fluorescence catheter: operating characteristics and feasibility for atherosclerotic plaque detection. J Phys D Appl Phys. 2005;38:2701-2707

  • Choi HK, Yessayan D, Choi HJ, Schellenberger E, Bogdanov A, Josephson L, Weissleder R, Ntziachristos V. Quantitative analysis of chemotherapeutic effects in tumors using in vivo staining and correlative histology. Cell Oncol. 2005;27(3):183-90 - PMID: 16037639 - PMCID: PMC4615174 - DOI: 10.1155/2005/791936

  • Zacharakis G, Ripoll J, Weissleder R, Ntziachristos V. Fluorescent protein tomography scanner for small animal imaging. IEEE T Med Imaging. 2005;24(7):878-85 - PMID: 16011317 - DOI: 10.1109/tmi.2004.843254

  • Law B, Weissleder R, Tung CH. Mechanism-Based Fluorescent Reporter for Protein Kinase A Detection. Chembiochem. 2005;6(8):1361-1367 - PMID: 16010698 - DOI: 10.1002/cbic.200500027

  • Montet X, Ntziachristos V, Grimm J, Weissleder R. Tomographic Fluorescence Mapping of Tumor Targets. Cancer Res. 2005;65 (14):6330-6336 - PMID: 16024635 - DOI: 10.1158/0008-5472.CAN-05-0382

  • Wunder A, Schellenberger E, Mahmood U, Bogdanov A Jr, Muller-Ladner U, Weissleder R, Josephson L. Methotrexate-induced accumulation of fluorescent annexin v in collagen-induced arthritis. Mol Imaging. 2005;4(1):1-6 - PMID: 15967121

  • Shah K, Tung CH, Breakefield X, Weissleder R. In vivo imaging of S-TRAIL-mediated tumor regression and apoptosis. Mol Ther. 2005;11 (6):926-931 - PMID: 15922963 - DOI: 10.1016/j.ymthe.2005.01.017

  • Bremer C, Ntziachristos V, Weitkamp B, Theilmeier G, Heindel W, Weissleder R. Optical Imaging of Spontaneous Breast Tumors Using Protease Sensing . Invest Radiol. 2005;(6):321-327 - PMID: 15905717 - DOI: 10.1097/01.rli.0000163797.23172.90

  • Alencar H, King R, Funovics M, Stout C, Weissleder R, Mahmood U. A novel mouse model for segmental orthotopic colon cancer. Int J Cancer. 2005;117(3):335-9 - PMID: 15900588 - DOI: 10.1002/ijc.21185

  • Yuan H, Luo J, Field S, Weissleder R, Cantley L, Josephson L. Synthesis and Activity of C11-Modified Wortmannin Probes for P13 Kinase. Bioconjug Chem. 2005;(3):669-675 - PMID: 15898736 - DOI: 10.1021/bc049714f

  • Tsourkas A, Shinde-Patil VR, Kelly KA, Patel P, Wolley A, Allport JR, Weissleder R. In Vivo Imaging of Activated Endothelium Using an Anti-VCAM-1 Magneto optical Probe. Bioconjug Chem. 2005;(3):576-581 - PMID: 15898724 - DOI: 10.1021/bc050002e

  • Querol M, Chen JW, Weissleder R, Bogdanov A Jr. DTPA-bisamide-Based MR Sensor Agents for Peroxidase Imaging. Org Lett. 2005;7(9):1719-22 - PMID: 15844889 - DOI: 10.1021/ol050208v

  • Tsourkas A, Newton G, Perez JM, Basilion J, Weissleder R. Detection of Peroxidase-Mediated Dityrosine Formation with Enhanced Yellow Fluorescent Protein. Anal Chem. 2005;77:2862-2867 - PMID: 15859603 - DOI: 10.1021/ac0480747

  • Chen J, Tung CH, Allport JR, Chen S, Weissleder R, Huang PL. Near-Infrared Fluorescent Imaging of Matrix Metalloproteinase Activity After Myocardial Infarction. Circulation. 2005;111:1800-1805 - PMID: 15809374 - PMCID: PMC3733536 - DOI: 10.1161/01.CIR.0000160936.91849.9F

  • Shinde Patil VR, Friedrich EB, Wolley AE, Gerszten RE, Allport JR, Weissleder R. Bone Marrow-Derived lin(-)c-kit(+)Sca-1(+) Stem Cells Do Not Contribute to Vasculogenesis in Lewis Lung Carcinoma. Neoplasia. 2005;7(3):234-40 - PMID: 15799823 - PMCID: PMC1501134 - DOI: 10.1593/neo.04523

  • Shah K, Weissleder R Molecular Optical Imaging: Applications Leading to the Development of Present Day Therapeutics. NeuroRx. 2005;2:215-225 - PMID: 15897946 - PMCID: PMC1064987 - DOI: 10.1602/neurorx.2.2.215

  • Gillies R, Hoffman J, Lam K, Menkens A, Piwnica-Worms D, Sullivan D, Weissleder R. Meeting Report: High-Throughput Technologies for In Vivo Imaging Agents. Mol Imaging. 2005;4:1-6

  • Galande A, Weissleder R, Tung CH. An Effective Method of On-Resin Disulfide Bond Formation in Peptides. J Comb Chem. 2005;7:174-177 - PMID: 15762743 - DOI: 10.1021/cc049839r

  • Ntziachristos V, Ripoll J, Wang L, Weissleder R Looking and Listening to light: the evolution of whole-body photonic imaging. Nat Biotechnol. 2005;23:313-320 - PMID: 15765087 - DOI: 10.1038/nbt1074

  • Tannous BA, Kim DE, Fernandez JL, Weissleder R, Breakefield XO. Codon-optimized gaussia luciferase cDNA for Mammalian gene expression in culture and in vivo. Mol Ther. 2005;11(3):435-43 - PMID: 15727940 - DOI: 10.1016/j.ymthe.2004.10.016

  • Jaffer F, Weissleder R Molecular Imaging in the Clinical Arena. JAMA. 2005;293(7):855-62 - PMID: 15713776 - DOI: 10.1001/jama.293.7.855

  • Law B, Hsiao JK, Bugge TH, Weissleder R, Tung CH. Optical zymography for specific detection of urokinase plasminogen activator activity in biological samples. Anal Biochem. 2005;338(1):151-158 - PMID: 15707946 - DOI: 10.1016/j.ab.2004.11.039

  • Tung CH, Quinti L, Jaffer F, Weissleder R A Branched Fluorescent Peptide Probe for Imaging of Activated Platelets. Mol Pharmacol. 2005;2:92-95 - PMID: 15804182 - DOI: 10.1021/mp0499048

  • Reynolds F, O'loughlin T, Weissleder R, Josephson L. Method of Determining Nanoparticle Core Weight. Anal Bioanal Chem. 2005;77(3):814-817 - PMID: 15679348 - DOI: 10.1021/ac049307x

  • Kim DE, Jaffer FA, Weissleder R, Tung CH, Schellingerhout D. Near-infrared fluorescent imaging of cerebral thrombi and blood-brain barrier disruption in a mouse model of cerebral venous sinus thrombosis. J Cereb Blood Flow Metab. 2005;25(2):226-33 - PMID: 15678125 - DOI: 10.1038/sj.jcbfm.9600023

  • Kelly KA, Allport JR, Tsourkas A, Shinde-Patil VR, Josephson L, Weissleder R. Detection of Vascular Adhesion Molecule-1 Expression Using a Novel Multimodal Nanoparticle. Circ Res. 2005;96(3):327-36 - PMID: 15653572 - DOI: 10.1161/01.RES.0000155722.17881.dd

  • Koch AM, Reynolds F, Merkle HP, Weissleder R, Josephson L. Transport Of Surface-Modified Nanoparticles Through Cell Monolayers. Chembiochem. 2005;6(2):337-345 - PMID: 15651046 - DOI: 10.1002/cbic.200400174

  • Chen WT, Mahmood U, Weissleder R, Tung CH Arthritis imaging using a near-infrared fluorescence folate-targeted probe. Arthritis Res Ther. 2005;7:R310-R317 - PMID: 15743478 - PMCID: PMC1065321 - DOI: 10.1186/ar1483

  • Chen ML, Pittet MJ, Gorelik L, Flavell RA, Weissleder R, von Boehmer H, Khazaie K. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-{beta} signals in vivo. Proc Natl Acad Sci U S A. 2005;102(2):419-24 - PMID: 15623559 - PMCID: PMC544311 - DOI: 10.1073/pnas.0408197102

  • Shah K, Bureau E, Kim DE, Yang K, Tang Y, Weissleder R, Breakefield XO. Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression. Ann Neurol. 2005;57(1):34-41 - PMID: 15622535 - DOI: 10.1002/ana.20306

  • Bogdanov AA Jr, Chen JW, Kang HW, Weissleder R. Magnetic resonance signal amplification probes. Ernst Schering Res Found Workshop. 2005;49:147-57 - PMID: 15524215 - DOI: 10.1007/3-540-26809-x_8

  • Tsourkas A, Weissleder R Illuminating the dynamics of intracellular activity with . Mech Chem Biosyst. 2004;1:133-45 - PMID: 16783939

  • Harisinghani MG, Weissleder R Sensitive, noninvasive detection of lymph node metastases. PLoS Med. 2004;1(3):e66 - PMID: 15630471 - PMCID: PMC539052 - DOI: 10.1371/journal.pmed.0010066

  • Chen WT, Tung CH, Weissleder R Imaging reactive oxygen species in arthritis. Mol Imaging. 2004;3(3):159-62 - PMID: 15530251 - DOI: 10.1162/1535350042380290

  • Metelev V, Weissleder R, Bogdanov A Jr Synthesis and Properties of Fluorescent NF-kappaB-Recognizing Hairpin Oligodeoxyribonucleotide Decoys. Bioconjug Chem. 2004;15(6):1481-1487 - PMID: 15546218 - DOI: 10.1021/bc049916b

  • Pham W, Choi Y, Weissleder R, Tung CH Developing a Peptide-Based Near-Infrared Molecular Probe for Protease Sensing. Bioconjug Chem. 2004;15(6):1403-1407 - PMID: 15546208 - DOI: 10.1021/bc049924s

  • Chen JW, Pham W, Weissleder R, Bogdanov A Jr Human myeloperoxidase: A potential target for molecular MR imaging in atherosclerosis. Magn Reson Med. 2004;52(5):1021-8 - PMID: 15508166 - DOI: 10.1002/mrm.20270

  • Graves EE, Weissleder R, Ntziachristos V Fluorescence molecular imaging of small animal tumor models. Curr Mol Med. 2004;4(4):419-30 - PMID: 15354872 - DOI: 10.2174/1566524043360555

  • Schellenberger EA, Sosnovik D, Weissleder R, Josephson L Magneto/Optical annexin v, a multimodal protein. Bioconjug Chem. 2004;15(5):1062-7 - PMID: 15366960 - DOI: 10.1021/bc049905i

  • Banerjee P, Reichardt W, Weissleder R, Bogdanov A Jr Novel hyperbranched dendron for gene transfer in vitro and in vivo. Bioconjug Chem. 2004;15(5):960-8 - PMID: 15366948 - DOI: 10.1021/bc0342128

  • Kelly K, Alencar H, Funovics M, Mahmood U, Weissleder R Detection of invasive colon cancer using a novel, targeted, library-derived fluorescent peptide. Cancer Res. 2004;64(17):6247-51 - PMID: 15342411 - DOI: 10.1158/0008-5472.CAN-04-0817

  • Wunder A, Tung CH, Muller-Ladner U, Weissleder R, Mahmood U In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment response. Arth Rheum/AR C Res. 2004;50(8):2459-65 - PMID: 15334458 - DOI: 10.1002/art.20379

  • Kim YR, Savellano MD, Savellano DH, Weissleder R, Bogdanov A Jr Measurement of tumor interstitial volume fraction: Method and implication for drug delivery. Magn Reson Med. 2004;52(3):485-94 - PMID: 15334566 - DOI: 10.1002/mrm.20182

  • Pham W, Kircher MF, Weissleder R, Tung CH Enhancing membrane permeability by Fatty acylation of oligoarginine peptides. Chembiochem. 2004;5(8):1148-51 - PMID: 15300843 - DOI: 10.1002/cbic.200400063

  • Ntziachristos V, Schellenberger EA, Ripoll J, Yessayan D, Graves E, Bogdanov A Jr, Josephson L, Weissleder R Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate. Proc Natl Acad Sci U S A. 2004;101(33):12294-9 - PMID: 15304657 - PMCID: PMC514472 - DOI: 10.1073/pnas.0401137101

  • Denis MC, Mahmood U, Benoist C, Mathis D, Weissleder R Imaging inflammation of the pancreatic islets in type 1 diabetes. Proc Natl Acad Sci U S A. 2004;101(34):12634-9 - PMID: 15304647 - PMCID: PMC515109 - DOI: 10.1073/pnas.0404307101

  • Law B, Curino A, Bugge TH, Weissleder R, Tung CH Design, synthesis, and characterization of urokinase plasminogen-activator-sensitive near-infrared reporter. Chem Biol. 2004;11(1):99-106 - PMID: 15112999 - DOI: 10.1016/j.chembiol.2003.12.017

  • Messerli SM, Prabhakar S, Tang Y, Shah K, Cortes ML, Murthy V, Weissleder R, Breakefield XO, Tung CH A novel method for imaging apoptosis using a caspase-1 near-infrared fluorescent probe. Neoplasia. 2004;6(2):95-105 - PMID: 15140398 - PMCID: PMC1502090 - DOI: 10.1593/neo.03214

  • Allport JR, Shinde Patil VR, Weissleder R Murine Neuronal Progenitor Cells are Preferentially Recruited to Tumor Vasculature via alpha(4)-integrin and SDF-1alpha-Dependent Mechanisms. Cancer Biol Ther. 2004;3(9):838-44 - PMID: 15254391 - DOI: 10.4161/cbt.3.9.1036

  • Kelly KA, Reynolds F, Weissleder R, Josephson L Fluorescein isothiocyanate-hapten immunoassay for determination of peptide-cell interactions. Anal Biochem. 2004;330(2):181-5 - PMID: 15203322 - DOI: 10.1016/j.ab.2004.02.035

  • Gondi CS, Lakka SS, Yanamandra N, Olivero WC, Dinh DH, Gujrati M, Tung CH, Weissleder R, Rao JS Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas. Cancer Res. 2004;64(12):4069-77 - PMID: 15205313 - DOI: 10.1158/0008-5472.CAN-04-1243

  • Jaffer FA, Tung CH, Wykrzykowska JJ, Ho NH, Houng AK, Reed GL, Weissleder R Molecular Imaging of Factor XIIIa Activity in Thrombosis Using a Novel, Near-Infrared Fluorescent Contrast Agent That Covalently Links to Thrombi. Circulation. 2004;110(2):170-6 - PMID: 15210587 - DOI: 10.1161/01.CIR.0000134484.11052.44

  • Funovics MA, Weissleder R, Mahmood U Catheter-based in vivo imaging of enzyme activity and gene expression: feasibility study in mice. Radiology. 2004;231(3):659-66 - PMID: 15163807 - DOI: 10.1148/radiol.2313030831

  • Shah K, Jacobs A, Breakefield XO, Weissleder R Molecular imaging of gene therapy for cancer. Gene Ther. 2004;11(15):1175-87 - PMID: 15141158 - DOI: 10.1038/sj.gt.3302278

  • Shah K, Tung CH, Yang K, Weissleder R, Breakefield XO Inducible release of TRAIL fusion proteins from a proapoptotic form for tumor therapy. Cancer Res. 2004;64(9):3236-42 - PMID: 15126365 - DOI: 10.1158/0008-5472.can-03-3516

  • Tsourkas A, Hofstetter O, Hofstetter H, Weissleder R, Josephson L Magnetic Relaxation Switch Immunosensors Detect Enantiomeric Impurities. Angew Chem Int Ed Engl. 2004;43(18):2395-2399 - PMID: 15114571 - DOI: 10.1002/anie.200352998

  • Schellenberger EA, Weissleder R, Josephson L Optimal modification of annexin v with fluorescent dyes. Chembiochem. 2004;5:271-4 - PMID: 14997518 - DOI: 10.1002/cbic.200300741

  • Schellenberger EA, Reynolds F, Weissleder R, Josephson L Surface-functionalized nanoparticle library yields probes for apoptotic cells. Chembiochem. 2004;5:275-9 - PMID: 14997519 - DOI: 10.1002/cbic.200300713

  • Perez JM, Josephson L, Weissleder R Use of magnetic nanoparticles as nanosensors to probe for molecular interactions. Chembiochem. 2004;5:261-4 - PMID: 14997516 - DOI: 10.1002/cbic.200300730

  • Kircher MF, Weissleder R, Josephson L A dual fluorochrome probe for imaging proteases. Bioconjug Chem. 2004;15:242-8 - PMID: 15025519 - DOI: 10.1021/bc034151d

  • Jaffer FA, Weissleder R Seeing within: molecular imaging of the cardiovascular system. Circ Res. 2004;94(4):433-45 - PMID: 15001542 - DOI: 10.1161/01.RES.0000119321.18573.5A

  • Kim DE, Schellingerhout D, Ishii K, Shah K, Weissleder R Imaging of Stem Cell Recruitment to Ischemic Infarcts in a Murine Model. Stroke. 2004;35:952-7 - PMID: 14988578 - DOI: 10.1161/01.STR.0000120308.21946.5D

  • Tung CH, Zeng Q, Shah K, Kim DE, Schellingerhout D, Weissleder R In Vivo Imaging of ?-Galactosidase Activity Using Far Red Fluorescent Switch. Cancer Res. 2004;64:1579-1583 - PMID: 14996712 - DOI: 10.1158/0008-5472.can-03-3226

  • Perez JM, Simeone FJ, Tsourkas A, Josephson L, Weissleder R Peroxidase substrate nanosensors for MR imaging. Nano Lett. 2004;4:119-122

  • Graves EE, Culver JP, Ripoll J, Weissleder R, Ntziachristos V Singular-value analysis and optimization of experimental parameters in fluorescence molecular tomography. J Opt Soc Am A . 2004;21(2):231-41 - PMID: 14763766 - DOI: 10.1364/josaa.21.000231

  • Grimm J, Perez JM, Josephson L, Weissleder R Novel nanosensors for rapid analysis of telomerase activity. Cancer Res. 2004;64:639-43 - PMID: 14744779 - DOI: 10.1158/0008-5472.can-03-2798

  • Shah K, Tung CH, Chang CH, Slootweg E, O'Loughlin T, Breakefield XO, Weissleder R In vivo imaging of HIV protease activity in amplicon vector-transduced gliomas. Cancer Res. 2004;64:273-8 - PMID: 14729634 - DOI: 10.1158/0008-5472.can-03-1123

  • Zhao M, Weissleder R Intracellular cargo delivery using tat peptide and derivatives. Med Res Rev. 2004;24:1-12 - PMID: 14595670 - DOI: 10.1002/med.10056

  • Pham W, Weissleder R, Tung CH A practical approach for the preparation of monofunctional azulenyl squaraine dye. Tetrahedron Lett. 2003;44(20):3975-3978 - PMID: 20740053 - PMCID: PMC2926986 - DOI: 10.1016/S0040-4039(03)00819-0

  • Hogemann-Savellano D, Bos E, Blondet C, Sato F, Abe T, Josephson L, Weissleder R, Gaudet J, Sgroi D, Peters PJ, Basilion JP. The transferrin receptor: a potential molecular imaging marker for human cancer. Neoplasia. 2003;5(6):495-506 - PMID: 14965443 - PMCID: PMC1502574 - DOI: 10.1016/s1476-5586(03)80034-9

  • Allport JR, Weissleder R Murine Lewis lung carcinoma-derived endothelium expresses markers of endothelial activation and requires tumor-specific extracellular matrix in vitro. Neoplasia. 2003;5:205-17 - PMID: 12869304 - PMCID: PMC1502407 - DOI: 10.1016/S1476-5586(03)80053-2

  • Bremer C, Ntziachristos V, Weissleder R Optical-based molecular imaging: contrast agents and potential medical applications. Eur J Radiol. 2003;13:231-43 - PMID: 12598985 - DOI: 10.1007/s00330-002-1610-0

  • Bremer C, Mustafa M, Bogdanov A Jr, Ntziachristos V, Petrovsky A, Weissleder R Steady-state blood volume measurements in experimental tumors with different angiogenic burdens a study in mice. Radiology. 2003;226:214-20 - PMID: 12511693 - DOI: 10.1148/radiol.2261012140

  • Funovics MA, Alencar H, Su HS, Khazaie K, Weissleder R, Mahmood U Miniaturized multichannel near infrared endoscope for mouse imaging. Mol Imaging. 2003;2:350-7 - PMID: 14717334 - DOI: 10.1162/153535003322750691

  • Funovics M, Weissleder R, Tung CH Protease sensors for bioimaging. Anal Bioanal Chem. 2003;377:956-63 - PMID: 12955390 - DOI: 10.1007/s00216-003-2199-0

  • Graves EE, Ripoll J, Weissleder R, Ntziachristos V A submillimeter resolution fluorescence molecular imaging system for small animal imaging. Med Phys. 2003;30:901-11 - PMID: 12772999 - DOI: 10.1118/1.1568977

  • Harisinghani MG, Barentsz J, Hahn PF, Deserno WM, Tabatabaei S, van de Kaa CH, de la Rosette J, Weissleder R Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med. 2003;348:2491-9 - PMID: 12815134 - DOI: 10.1056/NEJMoa022749

  • Josephson L, Mahmood U, Wunderbaldinger P, Tang Y, Weissleder R Pan and sentinel lymph node visualization using a near-infrared fluorescent probe. Mol Imaging. 2003;2:18-23 - PMID: 12926234 - DOI: 10.1162/153535003765276255

  • Kircher MF, Mahmood U, King RS, Weissleder R, Josephson L A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation. Cancer Res. 2003;63:8122-5 - PMID: 14678964

  • Kircher MF, Allport, JR, Graves EE, Love V, Josephson L, Lichtman AH, Weissleder R In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors. Cancer Res. 2003;63:6838-46 - PMID: 14583481

  • Koch AM, Reynolds F, Kircher MF, Merkle HP, Weissleder R, Josephson L Uptake and metabolism of a dual fluorochrome Tat-nanoparticle in HeLa cells. Bioconjug Chem. 2003;14:1115-21 - PMID: 14624624 - DOI: 10.1021/bc034123v

  • Lin Y, Weissleder R, Tung CH Synthesis and properties of sulfhydryl-reactive near-infrared cyanine fluorochromes for fluorescence imaging. Mol Imaging. 2003;2:87-92 - PMID: 12964306 - DOI: 10.1162/153535003322331975

  • Mahmood U, Weissleder R Near-infrared optical imaging of proteases in cancer. Mol Cancer Ther. 2003;2:489-96 - PMID: 12748311

  • Moffat BA, Reddy GR, McConville P, Hall DE, Chenevert TL, Kopelman RR, Philbert M, Weissleder R, Rehemtulla A, Ross BD A novel polyacrylamide magnetic nanoparticle contrast agent for molecular imaging using MRI. Mol Imaging. 2003;2:324-32 - PMID: 14717331 - DOI: 10.1162/153535003322750664

  • Moon, WK, Lin Y, O'Loughlin T, Tang Y, Kim DE, Weissleder R, Tung CH Enhanced tumor detection using a folate receptor-targeted near-infrared fluorochrome conjugate. Bioconjug Chem. 2003;14:539-45 - PMID: 12757377 - DOI: 10.1021/bc0340114

  • Ntziachristos V, Bremer C, Weissleder R Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging. Eur J Radiol. 2003;13:195-208 - PMID: 12541130 - DOI: 10.1007/s00330-002-1524-x

  • Perez JM, Simeone FJ, Saeki Y, Josephson L, Weissleder R Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological media. J Am Chem Soc. 2003;125:10192-3 - PMID: 12926940 - DOI: 10.1021/ja036409g

  • Petrovsky A, Schellenberger E, Josephson L, Weissleder R, Bogdanov A Jr Near-infrared fluorescent imaging of tumor apoptosis. Cancer Res. 2003;63:1936-42 - PMID: 12702586

  • Pham W, Lai WF, Weissleder R, Tung CH High efficiency synthesis of a bioconjugatable near-infrared fluorochrome. Bioconjug Chem. 2003;14:1048-51 - PMID: 13129411 - DOI: 10.1021/bc034070h

  • Rudin M, Weissleder R Molecular imaging in drug discovery and development. Nat Rev Drug Discov. 2003;2:123-31 - PMID: 12563303 - DOI: 10.1038/nrd1007

  • Schellenberger EA, Bogdanov A Jr, Petrovsky A, Ntziachristos V, Weissleder R, Josephson L Optical imaging of apoptosis as a biomarker of tumor response to chemotherapy. Neoplasia. 2003;5:187-92 - PMID: 12869301 - PMCID: PMC1502408 - DOI: 10.1016/S1476-5586(03)80050-7

  • Shah K, Tang Y, Breakefield X, Weissleder R Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo. Oncogene. 2003;22:6865-72 - PMID: 14534533 - DOI: 10.1038/sj.onc.1206748

  • Simonova M, Shtanko O, Sergeyev N, Weissleder R, Bogdanov A Jr Engineering of technetium-99m-binding artificial receptors for imaging gene expression. J Gene Med. 2003;5:1056-66 - PMID: 14661181 - DOI: 10.1002/jgm.448

  • Tang Y, Shah K, Messerli SM, Snyder E, Breakefield X, Weissleder R In vivo tracking of neural progenitor cell migration to glioblastomas. Hum Gene Ther. 2003;14:1247-54 - PMID: 12952596 - DOI: 10.1089/104303403767740786

  • Tung CH, Ho NH, Zeng Q, Tang Y, Jaffer FA, Reed GL, Weissleder R Novel Factor XIII Probes for Blood Coagulation Imaging. Chembiochem. 2003;4:897-899 - PMID: 12964167 - DOI: 10.1002/cbic.200300602

  • Tung CH, Weissleder R Arginine containing peptides as delivery vectors. Adv Drug Deliv Rev. 2003;55:281-94 - PMID: 12564981 - DOI: 10.1016/s0169-409x(02)00183-7

  • Weissleder R, Ntziachristos V Shedding light onto live molecular targets. Nature Med. 2003;9:123-8 - PMID: 12514725 - DOI: 10.1038/nm0103-123

  • Yip S, Aboody KS, Burns M, Imitola J, Boockvar JA, Allport J, Park KI, Teng YD, Lachyankar M, McIntosh T, O'Rourke DM, Khoury S, Weissleder R, Black PM, Weiss W, Snyder EY Neural stem cell biology may be well suited for improving brain tumor therapies. Cancer J. 2003;9:189-204 - PMID: 12952304 - DOI: 10.1097/00130404-200305000-00007

  • Zhao M, Josephson L, Tang Y, Weissleder R Magnetic sensors for protease assays. Angew Chem Int Ed Engl. 2003;42:1375-8 - PMID: 12671972 - DOI: 10.1002/anie.200390352

  • Ntziachristos V, Ripoll J, Weissleder R Would near-infrared fluorescence signals propagate through large human organs for clinical studies?. Opt Lett. 2002;27(5):333-5 - PMID: 18007794 - DOI: 10.1364/ol.27.000333

  • Ripoll J, Nieto-Vesperinas M, Weissleder R, Ntziachristos V Fast analytical approximation for arbitrary geometries in diffuse optical tomography. Opt Lett. 2002;27(7):527-9 - PMID: 18007854 - DOI: 10.1364/ol.27.000527

  • Ntziachristos V, Ripoll J, Weissleder R Would near-infrared fluorescence signals propagate through large human organs for clinical studies? Errata. Opt Lett. 2002;27(18):1652 - PMID: 18026531 - DOI: 10.1364/ol.27.001652

  • Pham W, Weissleder R, Tung CH Intermolecular [8+2] cycloaddition reactions of 2H-3-methoxycarbonylcyclohepta[b]furan-2-one with vinyl ethers: an approach to bicyclo[5.3.0]azulene derivatives. Tetrahedron Lett. 2002;43(1):19-20 - PMID: 20740048 - PMCID: PMC2926969 - DOI: 10.1016/S0040-4039(01)02061-5

  • Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell. 2002;1:269-77 - PMID: 12086863 - DOI: 10.1016/s1535-6108(02)00046-6

  • Bogdanov A Jr, Matuszewski L, Bremer C, Petrovsky A, Weissleder R Oligomerization of paramagnetic substrates result in signal amplification and can be used for MR imaging of molecular targets. Mol Imaging. 2002;1:16-23 - PMID: 12920857 - DOI: 10.1162/153535002753395671

  • Bogdanov AA Jr, Lin CP, Simonova M, Matuszewski L, Weissleder R Cellular activation of the self-quenched fluorescent reporter probe in tumor microenvironment. Neoplasia. 2002;4:228-36 - PMID: 11988842 - PMCID: PMC1531696 - DOI: 10.1038/sj/neo/7900238

  • Bremer C, Tung CH, Weissleder R Molecular imaging of MMP expression and therapeutic MMP inhibition. Acad Radiol. 2002;9 Suppl 2:S314-5 - PMID: 12188259 - DOI: 10.1016/s1076-6332(03)80214-3

  • Bremer C, Tung CH, Bogdanov A Jr, Weissleder R Imaging of differential protease expression in breast cancers for detection of aggressive tumor phenotypes. Radiology. 2002;222:814-8 - PMID: 11867806 - DOI: 10.1148/radiol.2223010812

  • Chen J, Tung CH, Mahmood U, Ntziachristos V, Gyurko R, Fishman MC, Huang PL, Weissleder R In vivo imaging of proteolytic activity in atherosclerosis. Circulation. 2002;105:2766-71 - PMID: 12057992 - DOI: 10.1161/01.cir.0000017860.20619.23

  • Harisinghani MG, Barentsz JO, Hahn PF, Deserno W, de la Rosette J, Saini S, Marten K, Weissleder R MR lymphangiography for detection of minimal nodal disease in patients with prostate cancer. Acad Radiol. 2002;9 Suppl 2:S312-3 - PMID: 12188258 - DOI: 10.1016/s1076-6332(03)80213-1

  • Hogemann D, Ntziachristos V, Josephson L, Weissleder R High throughput magnetic resonance imaging for evaluating targeted nanoparticle probes. Bioconjug Chem. 2002;13:116-21 - PMID: 11792186 - DOI: 10.1021/bc015549h

  • Ichikawa T, Hogemann D, Saeki Y, Tyminski E, Terada K, Weissleder R, Chiocca EA, Basilion JP MRI of transgene expression: correlation to therapeutic gene expression. Neoplasia. 2002;4:523-30 - PMID: 12407446 - PMCID: PMC1503666 - DOI: 10.1038/sj.neo.7900266

  • Jaffer FA, Tung CH, Gerszten RE, Weissleder R In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe. Arterioscler Thromb Vasc Biol. 2002;22:1929-35 - PMID: 12426227 - DOI: 10.1161/01.atv.0000033089.56970.2d

  • Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM, Boackle SA, Takahashi K, Holers VM, Walport M, Gerard C, Ezekowitz A, Carroll MC, Brenner M, Weissleder R, Verbeek JS, Duchatelle V, Degott C, Benoist C, Mathis D Arthritis critically dependent on innate immune system players. Immunity. 2002;16:157-68 - PMID: 11869678 - DOI: 10.1016/s1074-7613(02)00275-3

  • Josephson L, Kircher MF, Mahmood U, Tang Y, Weissleder R Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjug Chem. 2002;13:554-60 - PMID: 12009946 - DOI: 10.1021/bc015555d

  • Kang HW, Weissleder R, Bogdanov A Jr Targeting of MPEG-protected polyamino acid carrier to human E-selectin in vitro. Amino Acids. 2002;23:301-8 - PMID: 12373551 - DOI: 10.1007/s00726-001-0142-2

  • Kang HW, Josephson L, Petrovsky A, Weissleder R, Bogdanov A Jr Magnetic resonance imaging of inducible E-selectin expression in human endothelial cell culture. Bioconjug Chem. 2002;13:122-7 - PMID: 11792187 - DOI: 10.1021/bc0155521

  • Kim YR, Savellano MD, Weissleder R, Bogdanov A Jr Steady-state and dynamic contrast MR imaging of human prostate cancer xenograft tumors: a comparative study. Technol Cancer Res T. 2002;1:489-95 - PMID: 12625776 - DOI: 10.1177/153303460200100609

  • Kircher MF, Josephson L, Weissleder R Ratio imaging of enzyme activity using dual wavelength optical reporters. Mol Imaging. 2002;1:89-95 - PMID: 12920849 - DOI: 10.1162/153535002320162741

  • Lin Y, Weissleder R, Tung CH Novel near-infrared cyanine fluorochromes: synthesis, properties, and bioconjugation. Bioconjug Chem. 2002;13:605-10 - PMID: 12009952 - DOI: 10.1021/bc0155723

  • Mahmood U, Tung CH, Tang Y, Weissleder R Feasibility of in vivo multichannel optical imaging of gene expression: experimental study in mice. Radiology. 2002;224:446-51 - PMID: 12147841 - DOI: 10.1148/radiol.2242011589

  • Mahmood U, Weissleder R Some tools for molecular imaging. Acad Radiol. 2002;9:629-31 - PMID: 12061735 - DOI: 10.1016/s1076-6332(03)80306-9

  • Marten K, Bremer C, Khazaie K, Sameni M, Sloane B, Tung CH, Weissleder R Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice. Gastroenterology. 2002;122:406-14 - PMID: 11832455 - DOI: 10.1053/gast.2002.30990

  • Melder RJ, Munn LL, Stoll BR, Marecos EM, Baxter LT, Weissleder R, Jain RK Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model. Neoplasia. 2002;4:3-8 - PMID: 11922388 - PMCID: PMC1503314 - DOI: 10.1038/sj/neo/7900209

  • Messerli SM, Tang Y, Giovannini M, Bronson R, Weissleder R, Breakefield XO Detection of spontaneous schwannomas by MRI in a transgenic murine model of neurofibromatosis type 2. Neoplasia. 2002;4:501-9 - PMID: 12407444 - PMCID: PMC1503664 - DOI: 10.1038/sj.neo.7900265

  • Moore, A, Sun PZ, Cory D, Hogemann D, Weissleder R, Lipes MA MRI of insulitis in autoimmune diabetes. Magn Reson Med. 2002;47:751-8 - PMID: 11948737 - DOI: 10.1002/mrm.10110

  • Ntziachristos, V, Bremer C, Graves EE, Ripoll J, Weissleder R In vivo tomographic imaging of near-infrared fluorescent probes. Mol Imaging. 2002;1:82-8 - PMID: 12920848 - DOI: 10.1162/153535002320162732

  • Ntziachristos, V, Bremer C, Tung C, Weissleder R Imaging cathepsin B up-regulation in HT-1080 tumor models using fluorescence-mediated molecular tomography (FMT). Acad Radiol. 2002;9 Suppl 2:S323-5 - PMID: 12188262 - DOI: 10.1016/s1076-6332(03)80217-9

  • Ntziachristos V, Tung CH, Bremer C, Weissleder R Fluorescence molecular tomography resolves protease activity in vivo. Nature Med. 2002;8:757-60 - PMID: 12091907 - DOI: 10.1038/nm729

  • Ntziachristos V, Weissleder R Charge-coupled-device based scanner for tomography of fluorescent near-infrared probes in turbid media. Med Phys. 2002;29:803-9 - PMID: 12033576 - DOI: 10.1118/1.1470209

  • Perez JM, Josephson L, O'Loughlin T, Hogemann D, Weissleder R Magnetic relaxation switches capable of sensing molecular interactions. Nat Biotechnol. 2002;20:816-20 - PMID: 12134166 - DOI: 10.1038/nbt720

  • Perez JM, O'Loughin T, Simeone F J, Weissleder R, Josephson L DNA-based magnetic nanoparticle assembly acts as a magnetic relaxation nanoswitch allowing screening of DNA-cleaving agents. J Am Chem Soc. 2002;124:2856-7 - PMID: 11902860 - DOI: 10.1021/ja017773n

  • Pham W, Weissleder R, Tung CH An azulene dimer as a near-infrared quencher. Angew Chem Int Ed Engl. 2002;41:3659-62, 3519 - PMID: 12370922 - DOI: 10.1002/1521-3773(20021004)41:19&lt;3659::AID-ANIE3659&gt;3.0.CO;2-Q

  • Schellenberger EA, Bogdanov A Jr, Hogemann D, Tait J, Weissleder R, Josephson L Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI. Mol Imaging. 2002;1:102-7 - PMID: 12920851 - DOI: 10.1162/153535002320162769

  • Schellenberger EA, Hogemann D, Josephson L, Weissleder R Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI. Acad Radiol. 2002;9 Suppl 2:S310-1 - PMID: 12188257 - DOI: 10.1016/s1076-6332(03)80212-x

  • Schellingerhout D, Accorsi R, Mahmood U, Idoine J, Lanza RC, Weissleder R Coded aperture nuclear scintigraphy: a novel small animal imaging technique. Mol Imaging. 2002;1:344-53 - PMID: 12926230 - DOI: 10.1162/153535002321093954

  • Tung CH, Mueller S, Weissleder R Novel branching membrane translocational peptide as gene delivery vector. Bioorg Med Chem. 2002;10:3609-14 - PMID: 12213476 - DOI: 10.1016/s0968-0896(02)00248-1

  • Tung CH, Lin Y, Moon WK, Weissleder R A receptor-targeted near-infrared fluorescence probe for in vivo tumor imaging. Chembiochem. 2002;3:784-6 - PMID: 12203978 - DOI: 10.1002/1439-7633(20020802)3:8&lt;784::AID-CBIC784&gt;3.0.CO;2-X

  • Tung CH, Gerszten RE, Jaffer FA, Weissleder R A novel near-infrared fluorescence sensor for detection of thrombin activation in blood. Chembiochem. 2002;3:207-11 - PMID: 11921399 - DOI: 10.1002/1439-7633(20020301)3:2/3&lt;207::AID-CBIC207&gt;3.0.CO;2-B

  • Weissleder R Scaling down imaging: molecular mapping of cancer in mice. Nat Rev Cancer. 2002;2:1-8 - PMID: 11902581 - DOI: 10.1038/nrc701

  • Wunderbaldinger P, Josephson L, Weissleder R Crosslinked iron oxides (CLIO): a new platform for the development of targeted MR contrast agents. Acad Radiol. 2002;9 Suppl 2:S304-6 - PMID: 12188255 - DOI: 10.1016/s1076-6332(03)80210-6

  • Wunderbaldinger P, Josephson L, Weissleder R Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles. Bioconjug Chem. 2002;13:264-8 - PMID: 11906263 - DOI: 10.1021/bc015563u

  • Wunderbaldinger P, Josephson L, Bremer C, Moore A, Weissleder R Detection of lymph node metastases by contrast-enhanced MRI in an experimental model. Magn Reson Med. 2002;47:292-7 - PMID: 11810672 - DOI: 10.1002/mrm.10068

  • Zhao M, Kircher MF, Josephson L, Weissleder R Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake. Bioconjug Chem. 2002;13:840-4 - PMID: 12121140 - DOI: 10.1021/bc0255236

  • Josephson L, Perez JM, Weissleder R Magnetic Nanosensors for the Detection of Oligonucleotide Sequences. Angew Chem Int Ed Engl. 2001;40(17):3204-3206 - PMID: 29712059 - DOI: 10.1002/1521-3773(20010903)40:17&lt;3204::AID-ANIE3204&gt;3.0.CO;2-H

  • Ntziachristos V, Weissleder R Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation. Opt Lett. 2001;26(12):893-5 - PMID: 18040483 - DOI: 10.1364/ol.26.000893

  • Allport JR, Weissleder R In vivo imaging of gene and cell therapies. Exp Hematol. 2001;29:1237-46 - PMID: 11698119 - DOI: 10.1016/s0301-472x(01)00739-1

  • Bogdanov A Jr, Tung CH, Bredow S, Weissleder R DNA binding chelates for nonviral gene delivery imaging. Gene Ther. 2001;8:515-22 - PMID: 11319618 - DOI: 10.1038/sj.gt.3301410

  • Bremer C, Bredow S, Mahmood U, Weissleder R, Tung CH Optical imaging of matrix metalloproteinase-2 activity in tumors: feasibility study in a mouse model. Radiology. 2001;221:523-9 - PMID: 11687699 - DOI: 10.1148/radiol.2212010368

  • Bremer C, Tung CH, Weissleder R In vivo molecular target assessment of matrix metalloproteinase inhibition. Nature Med. 2001;7:743-8 - PMID: 11385514 - DOI: 10.1038/89126

  • Bremer C, Bogdanov AA, Weissleder R [Imaging of angiogenesis]. Radiologe. 2001;41:138-45 - PMID: 11253099 - DOI: 10.1007/s001170050956

  • Bremer C, Ntziachristos V, Mahmood U, Tung CH, Weissleder R [Progress in optical imaging]. Radiologe. 2001;41:131-7 - PMID: 11253098 - DOI: 10.1007/s001170050955

  • Bremer C, Weissleder R In vivo imaging of gene expression. Acad Radiol. 2001;8:15-23 - PMID: 11201452 - DOI: 10.1016/s1076-6332(03)80739-0

  • Dodd CH, Hsu HC, Chu WJ, Yang P, Zhang HG, Mountz JD Jr, Zinn K, Forder J, Josephson L, Weissleder R, Mountz JM, Mountz JD Normal T-cell response and in vivo magnetic resonance imaging of T cells loaded with HIV transactivator-peptide-derived superparamagnetic nanoparticles. J Immunol Methods. 2001;256:89-105 - PMID: 11516758 - DOI: 10.1016/s0022-1759(01)00433-1

  • Harisinghani MG, Jhaveri KS, Weissleder R, Schima W, Saini S, Hahn PF, Mueller PR MRI contrast agents for evaluating focal hepatic lesions. Clin Radiol. 2001;56:714-25 - PMID: 11585393 - DOI: 10.1053/crad.2001.0764

  • Harisinghani MG, Saini S, Weissleder R, Rubin D, deLange E, Harms S, Weinreb J, Small W, Sukerkar A, Brown JJ, Zelch J, Lucas M, Morris M, Hahn PF Splenic imaging with ultrasmall superparamagnetic iron oxide ferumoxtran-10 (AMI-7227): preliminary observations. J Comput Assist Tomogr. 2001;25:770-6 - PMID: 11584239 - DOI: 10.1097/00004728-200109000-00017

  • Hogemann D, Basilion JP, Weissleder R [Molecular imaging in magnetic resonance tomography and nuclear medicine]. Radiologe. 2001;41:116-20 - PMID: 11253096 - DOI: 10.1007/s001170050953

  • Moore A, Bonner-Weir S, Weissleder R Noninvasive in vivo measurement of beta-cell mass in mouse model of diabetes. Diabetes. 2001;50:2231-6 - PMID: 11574403 - DOI: 10.2337/diabetes.50.10.2231

  • Moore A, Josephson L, Bhorade RM, Basilion JP, Weissleder R Human transferrin receptor gene as a marker gene for MR imaging. Radiology. 2001;221:244-50 - PMID: 11568347 - DOI: 10.1148/radiol.2211001784

  • O'Neill MJ, Weissleder R, Gervais DA, Hahn PF, Mueller PR Tunneled peritoneal catheter placement under sonographic and fluoroscopic guidance in the palliative treatment of malignant ascites. AJR Am J Roentgenol. 2001;177:615-8 - PMID: 11517056 - DOI: 10.2214/ajr.177.3.1770615

  • Spear MA, Breakefield XO, Beltzer J, Schuback D, Weissleder R, Pardo FS, Ladner R Isolation, characterization, and recovery of small peptide phage display epitopes selected against viable malignant glioma cells. Cancer Gene Ther. 2001;8:506-11 - PMID: 11498772 - DOI: 10.1038/sj.cgt.7700334

  • Wagenaar DJ, Weissleder R, Hengerer A Glossary of molecular imaging terminology. Acad Radiol. 2001;8:409-20 - PMID: 11345272 - DOI: 10.1016/S1076-6332(03)80549-4

  • Weissleder R, Mahmood U Molecular imaging. Radiology. 2001;219:316-33 - PMID: 11323453 - DOI: 10.1148/radiology.219.2.r01ma19316

  • Weissleder R, Bogdanov A Jr, Tung CH, Weinmann HJ Size optimization of synthetic graft copolymers for in vivo angiogenesis imaging. Bioconjug Chem. 2001;12:213-9 - PMID: 11312682 - DOI: 10.1021/bc000091p

  • Weissleder R A clearer vision for in vivo imaging. Nat Biotechnol. 2001;19:316-7 - PMID: 11283581 - DOI: 10.1038/86684

  • Weissleder R [Experimental radiology in the USA]. Radiologe. 2001;41:115 - PMID: 11253095 - DOI: 10.1007/s001170050952

  • Wunderbaldinger P, Weissleder R [Experimental and clinical approaches to lymph node imaging]. Radiologe. 2001;41:121-30 - PMID: 11253097 - DOI: 10.1007/s001170050954

  • Contag C, Fraser S, Weissleder, R Strategies in in vivo molecular imaging. Neoreviews. 2000;1:225-232

  • Contag C, Weissleder R, Bachmann M, Fraser S Appllications of In Vivo Molecular Imaging in Biology and Medicine. Neoreviews. 2000;1:233-240

  • Bhorade R, Weissleder R, Nakakoshi T, Moore A, Tung CH Macrocyclic chelators with paramagnetic cations are internalized into mammalian cells via a HIV-tat derived membrane translocation peptide. Bioconjug Chem. 2000;11:301-5 - PMID: 10821645 - DOI: 10.1021/bc990168d

  • Bogdanov AA Jr, Simonova M, Weissleder R Engineering membrane proteins for nuclear medicine: applications for gene therapy and cell tracking. Q J Nucl Med Mol IM. 2000;44:224-35 - PMID: 11105587

  • Bredow S, Lewin M, Hofmann B, Marecos E, Weissleder R Imaging of tumour neovasculature by targeting the TGF-beta binding receptor endoglin. Eur J Cancer. 2000;36:675-81 - PMID: 10738134 - DOI: 10.1016/s0959-8049(99)00335-4

  • Hogemann D, Josephson L, Weissleder R, Basilion JP Improvement of MRI probes to allow efficient detection of gene expression. Bioconjug Chem. 2000;11:941-6 - PMID: 11087345 - DOI: 10.1021/bc000079x

  • Lewin M, Carlesso N, Tung CH, Tang XW, Cory D, Scadden DT, Weissleder R Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat Biotechnol. 2000;18:410-4 - PMID: 10748521 - DOI: 10.1038/74464

  • Moore A, Marecos E, Bogdanov A Jr, Weissleder R Tumoral distribution of long-circulating dextran-coated iron oxide nanoparticles in a rodent model. Radiology. 2000;214:568-74 - PMID: 10671613 - DOI: 10.1148/radiology.214.2.r00fe19568

  • Schellingerhout D, Rainov NG, Breakefield XO, Weissleder R Quantitation of HSV mass distribution in a rodent brain tumor model. Gene Ther. 2000;7:1648-55 - PMID: 11083473 - DOI: 10.1038/sj.gt.3301272

  • Simonova M, Wall A, Weissleder R, Bogdanov A Jr Tyrosinase mutants are capable of prodrug activation in transfected nonmelanotic cells. Cancer Res. 2000;60:6656-62 - PMID: 11118049

  • Tung CH, Mahmood U, Bredow S, Weissleder R In vivo imaging of proteolytic enzyme activity using a novel molecular reporter. Cancer Res. 2000;60:4953-8 - PMID: 10987312

  • Weissleder R, Moore A, Mahmood U, Bhorade R, Benveniste H, Chiocca EA, Basilion JP In vivo magnetic resonance imaging of transgene expression. Nature Med. 2000;6:351-5 - PMID: 10700241 - DOI: 10.1038/73219

  • Wunderbaldinger P, Bogdanov A, Weissleder R New approaches for imaging in gene therapy. Eur J Radiol. 2000;34:156-65 - PMID: 10927158 - DOI: 10.1016/s0720-048x(00)00196-0

  • Bogdanov A Jr, Marecos E, Cheng HC, Chandrasekaran L, Krutzsch HC, Roberts DD, Weissleder R Treatment of experimental brain tumors with trombospondin-1 derived peptides: an in vivo imaging study. Neoplasia. 1999;1:438-45 - PMID: 10933059 - PMCID: PMC1508110 - DOI: 10.1038/sj.neo.7900044

  • Bogdanov AA, Lewin M, Weissleder R Approaches and agents for imaging the vascular system. Adv Drug Deliv Rev. 1999;37:279-293 - PMID: 10837740 - DOI: 10.1016/s0169-409x(98)00098-2

  • Enochs WS, Harsh G, Hochberg F, Weissleder R Improved delineation of human brain tumors on MR images using a long-circulating, superparamagnetic iron oxide agent. J Magn Reson Imaging. 1999;9:228-32 - PMID: 10077018 - DOI: 10.1002/(sici)1522-2586(199902)9:2&lt;228::aid-jmri12&gt;3.0.co;2-k

  • Harisinghani MG, Saini S, Weissleder R, Hahn PF, Yantiss RK, Tempany C, Wood BJ, Mueller PR MR lymphangiography using ultrasmall superparamagnetic iron oxide in patients with primary abdominal and pelvic malignancies: radiographic-pathologic correlation. AJR Am J Roentgenol. 1999;172:1347-51 - PMID: 10227514 - DOI: 10.2214/ajr.172.5.10227514

  • Hofmann, B, Bogdanov A Jr, Marecos E, Ebert W, Semmler W, Weissleder R Mechanism of gadophrin-2 accumulation in tumor necrosis. J Magn Reson Imaging. 1999;9:336-41 - PMID: 10077034 - DOI: 10.1002/(sici)1522-2586(199902)9:2&lt;336::aid-jmri28&gt;3.0.co;2-3

  • Josephson L, Tung CH, Moore A, Weissleder R High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates. Bioconjug Chem. 1999;10:186-91 - PMID: 10077466 - DOI: 10.1021/bc980125h

  • Lewin M, Bredow S, Sergeyev N, Marecos E, Bogdanov A Jr, Weissleder R In vivo assessment of vascular endothelial growth factor-induced angiogenesis. Int J Cancer. 1999;83:798-802 - PMID: 10597197 - DOI: 10.1002/(sici)1097-0215(19991210)83:6&lt;798::aid-ijc16&gt;3.0.co;2-w

  • Mahmood U, Tung CH, Bogdanov A Jr, Weissleder R Near-infrared optical imaging of protease activity for tumor detection. Radiology. 1999;213:866-70 - PMID: 10580968 - DOI: 10.1148/radiology.213.3.r99dc14866

  • Schima W, Saini S, Petersein J, Weissleder R, Harisinghani M, Mayo-Smith W, Hahn PF MR imaging of the liver with Gd-BOPTA: quantitative analysis of T1-weighted images at two different doses. J Magn Reson Imaging. 1999;10:80-3 - PMID: 10398981 - DOI: 10.1002/(sici)1522-2586(199907)10:1&lt;80::aid-jmri11&gt;3.0.co;2-s

  • Simonova M, Weissleder R, Sergeyev N, Vilissova N, Bogdanov A Jr Targeting of green fluorescent protein expression to the cell surface. Biochem Bioph Res Co. 1999;262:638-42 - PMID: 10471377 - DOI: 10.1006/bbrc.1999.1251

  • Tung CH, Bredow S, Mahmood U, Weissleder R Preparation of a cathepsin D sensitive near-infrared fluorescence probe for imaging. Bioconjug Chem. 1999;10:892-6 - PMID: 10502358 - DOI: 10.1021/bc990052h

  • Weissleder R Molecular imaging: exploring the next frontier. Radiology. 1999;212:609-14 - PMID: 10478223 - DOI: 10.1148/radiology.212.3.r99se18609

  • Weissleder R, Tung CH, Mahmood U, Bogdanov A Jr In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat Biotechnol. 1999;17:375-8 - PMID: 10207887 - DOI: 10.1038/7933

  • Zaharchuk G, Mandeville JB, Bogdanov AA Jr, Weissleder R, Rosen BR, Marota JJ Cerebrovascular dynamics of autoregulation and hypoperfusion. An MRI study of CBF and changes in total and microvascular cerebral blood volume during hemorrhagic hypotension. Stroke. 1999;30:2197-204; discussion 2204-5 - PMID: 10512929 - DOI: 10.1161/01.str.30.10.2197

  • Moore A, Weissleder R, Bogdanov A Uptake of dextran-coated monocrystalline iron oxides in tumor cells and macrophages. J Magn Reson Imaging. 1998;7(6):1140-5 - PMID: 9400860 - DOI: 10.1002/jmri.1880070629

  • Bogdanov A, Weissleder R The development of in vivo imaging systems to study gene expression. Trends Biotechnol. 1998;16(1):5-10 - PMID: 9470227 - DOI: 10.1016/S0167-7799(97)01150-5

  • Mandeville JB, Marota JJ, Kosofsky BE, Keltner JR, Weissleder R, Rosen BR, Weisskoff RM Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation. Magn Reson Med. 1998;39(4):615-24 - PMID: 9543424 - DOI: 10.1002/mrm.1910390415

  • Bogdanov A, Simonova M, Weissleder R Design of metal-binding green fluorescent protein variants. Biochim Biophys Acta. 1998;1397(1):56-64 - PMID: 9545533 - DOI: 10.1016/s0167-4781(97)00221-2

  • Marecos E, Weissleder R, Bogdanov A Antibody-mediated versus nontargeted delivery in a human small cell lung carcinoma model. Bioconjug Chem. 1998;9(2):184-91 - PMID: 9548533 - DOI: 10.1021/bc970146w

  • Harisinghani MG, Saini S, Hahn PF, Weissleder R, Mueller PR MR imaging of lymph nodes in patients with primary abdominal and pelvic malignancies using ultrasmall superparamagnetic iron oxide (Combidex). Acad Radiol. 1998;5 Suppl 1:S167-9, discussion S183-4 - PMID: 9561072 - DOI: 10.1016/s1076-6332(98)80095-0

  • Spear MA, Herrlinger U, Rainov N, Pechan P, Weissleder R, Breakefield XO Targeting gene therapy vectors to CNS malignancies. J Neurovirol. 1998;4(2):133-47 - PMID: 9584951 - DOI: 10.3109/13550289809114514

  • Moore A, Basilion JP, Chiocca EA, Weissleder R Measuring transferrin receptor gene expression by NMR imaging. Biochim Biophys Acta. 1998;1402(3):239-49 - PMID: 9606982 - DOI: 10.1016/s0167-4889(98)00002-0

  • Schoepf U, Marecos EM, Melder RJ, Jain RK, Weissleder R Intracellular magnetic labeling of lymphocytes for in vivo trafficking studies. Biotechniques. 1998;24(4):642-6, 648-51 - PMID: 9564539 - DOI: 10.2144/98244rr01

  • Reimer P, Bader A, Weissleder R Preclinical assessment of hepatocyte-targeted MR contrast agents in stable human liver cell cultures. J Magn Reson Imaging. 1998;8(3):687-9 - PMID: 9626887 - DOI: 10.1002/jmri.1880080326

  • de Marco G, Bogdanov A, Marecos E, Moore A, Simonova M, Weissleder R MR imaging of gene delivery to the central nervous system with an artificial vector. Radiology. 1998;208(1):65-71 - PMID: 9646794 - DOI: 10.1148/radiology.208.1.9646794

  • Callahan RJ, Bogdanov A, Fischman AJ, Brady TJ, Weissleder R Preclinical evaluation and phase I clinical trial of a 99mTc-labeled synthetic polymer used in blood pool imaging. AJR Am J Roentgenol. 1998;171(1):137-43 - PMID: 9648777 - DOI: 10.2214/ajr.171.1.9648777

  • Schellingerhout D, Bogdanov A, Marecos E, Spear M, Breakefield X, Weissleder R Mapping the in vivo distribution of herpes simplex virions. Hum Gene Ther. 1998;9(11):1543-9 - PMID: 9694153 - DOI: 10.1089/hum.1998.9.11-1543

  • Boiselle PM, Patz EF, Vining DJ, Weissleder R, Shepard JA, McLoud TC Imaging of mediastinal lymph nodes: CT, MR, and FDG PET. Radiographics. 1998;18(5):1061-9 - PMID: 9747607 - DOI: 10.1148/radiographics.18.5.9747607

  • Zaharchuk G, Bogdanov AA, Marota JJ, Shimizu-Sasamata M, Weisskoff RM, Kwong KK, Jenkins BG, Weissleder R, Rosen BR Continuous assessment of perfusion by tagging including volume and water extraction (CAPTIVE): a steady-state contrast agent technique for measuring blood flow, relative blood volume fraction, and the water extraction fraction. Magn Reson Med. 1998;40(5):666-78 - PMID: 9797148 - DOI: 10.1002/mrm.1910400504

  • Moore A, Marecos E, Simonova M, Weissleder R, Bogdanov A Novel gliosarcoma cell line expressing green fluorescent protein: A model for quantitative assessment of angiogenesis. Microvasc Res. 1998;56(3):145-53 - PMID: 9828152 - DOI: 10.1006/mvre.1998.2102

  • Frank H, Loewe R, Loewe C, Oberhuber G, Schwaighofer B, Huber K, Weissleder R Efficacy of thrombolytic therapy in pulmonary embolism determined by MION-enhanced MRA: an experimental study in rabbits. Invest Radiol. 1998;33(12):853-7 - PMID: 9851818 - DOI: 10.1097/00004424-199812000-00002

  • Weissleder R, Cheng HC, Marecos E, Kwong K, Bogdanov A Non-invasive in vivo mapping of tumour vascular and interstitial volume fractions. Eur J Cancer. 1998;34(9):1448-54 - PMID: 9849430 - DOI: 10.1016/s0959-8049(98)00195-6

  • Stiskal M, Schwickert HC, Demsar F, Roberts TP, Szolar D, Weissleder R, Brasch RC Contrast enhancement in experimental radiation-induced liver injury: comparison of hepatocellular and reticuloendothelial particulate contrast agents. J Magn Reson Imaging. 1997;6(2):286-90 - PMID: 9132091 - DOI: 10.1002/jmri.1880060205

  • Zimmer C, Wright SC, Engelhardt RT, Johnson GA, Kramm C, Breakefield XO, Weissleder R Tumor cell endocytosis imaging facilitates delineation of the glioma-brain interface. Exp Neurol. 1997;143(1):61-9 - PMID: 9000446 - DOI: 10.1006/exnr.1996.6350

  • Weissleder R, Cheng HC, Bogdanova A, Bogdanov A Magnetically labeled cells can be detected by MR imaging. J Magn Reson Imaging. 1997;7(1):258-63 - PMID: 9039625 - DOI: 10.1002/jmri.1880070140

  • Bogdanov A, Wright SC, Marecos EM, Bogdanova A, Martin C, Petherick P, Weissleder R A long-circulating co-polymer in &amp;quot;passive targeting&amp;quot; to solid tumors. J Drug Target. 1997;4(5):321-30 - PMID: 9169989 - DOI: 10.3109/10611869708995848

  • Reimer P, Bader A, Weissleder R Application of a stable cell culture assay for the functional assessment of novel MR contrast agents. Eur Radiol. 1997;7(4):527-31 - PMID: 9204333 - DOI: 10.1007/s003300050197

  • Harisinghani MG, Saini S, Weissleder R, Halpern EF, Schima W, Rubin DL, Stillman AE, Sica GT, Small WC, Hahn PF Differentiation of liver hemangiomas from metastases and hepatocellular carcinoma at MR imaging enhanced with blood-pool contrast agent Code-7227. Radiology. 1997;202(3):687-91 - PMID: 9051017 - DOI: 10.1148/radiology.202.3.9051017

  • Mandeville JB, Moore J, Chesler DA, Garrido L, Weissleder R, Weisskoff RM Dynamic liver imaging with iron oxide agents: effects of size and biodistribution on contrast. Magn Reson Med. 1997;37(6):885-90 - PMID: 9178240 - DOI: 10.1002/mrm.1910370613

  • Enochs WS, Petherick P, Bogdanova A, Mohr U, Weissleder R Paramagnetic metal scavenging by melanin: MR imaging. Radiology. 1997;204(2):417-23 - PMID: 9240529 - DOI: 10.1148/radiology.204.2.9240529

  • Weissleder R, Simonova M, Bogdanova A, Bredow S, Enochs WS, Bogdanov A MR imaging and scintigraphy of gene expression through melanin induction. Radiology. 1997;204(2):425-9 - PMID: 9240530 - DOI: 10.1148/radiology.204.2.9240530

  • Cheng HC, Khan MA, Bogdanov A, Kwong K, Weissleder R Relative blood volume measurements by magnetic resonance imaging facilitate detection of testicular torsion. Invest Radiol. 1997;32(12):763-9 - PMID: 9406017 - DOI: 10.1097/00004424-199712000-00007

  • Bogdanov A, Petherick P, Marecos E, Weissleder R In vivo localization of diglycylcysteine-bearing synthetic peptides by nuclear imaging of oxotechnetate transchelation. Nucl Med Biol. 1997;24(8):739-42 - PMID: 9428599 - DOI: 10.1016/s0969-8051(97)00117-0

  • Bader A, Reimer P, Knop E, Boker K, Christians U, Weissleder R, Sewing KF An organotypical in vitro model of the liver parenchyma for uptake studies of diagnostic MR receptor agents. Magn Reson Imaging. 1996;13(7):991-1002 - PMID: 8583878 - DOI: 10.1016/0730-725x(95)00053-j

  • Bogdanov AA, Martin C, Bogdanova AV, Brady TJ, Weissleder R An adduct of cis-diamminedichloroplatinum(II) and poly(ethylene glycol)poly(L-lysine)-succinate: synthesis and cytotoxic properties. Bioconjug Chem. 1996;7(1):144-9 - PMID: 8742003 - DOI: 10.1021/bc950089b

  • Papisov M, Weissleder R Drug delivery to lymphatic tissue. Crit Rev Ther Drug Carrier Syst. 1996;13(1-2):57-84 - PMID: 8853959

  • Harika L, Weissleder R, Poss K, Papisov MI Macromolecular intravenous contrast agent for MR lymphography: characterization and efficacy studies. Radiology. 1996;198(2):365-70 - PMID: 8596833 - DOI: 10.1148/radiology.198.2.8596833

  • Gupta H, Weissleder R Targeted contrast agents in MR imaging. Magn Reson Imaging. 1996;4(1):171-84 - PMID: 8673713

  • Petersein J, Saini S, Weissleder R Liver. II: Iron oxide-based reticuloendothelial contrast agents for MR imaging. Clinical review. Magn Reson Imaging. 1996;4(1):53-60 - PMID: 8673716

  • Reimer P, Weissleder R [Development and experimental use of receptor-specific MR contrast media]. Radiologe. 1996;36(2):153-63 - PMID: 8867433 - DOI: 10.1007/s001170050053

  • Remsen LG, McCormick CI, Roman-Goldstein S, Nilaver G, Weissleder R, Bogdanov A, Hellström I, Kroll RA, Neuwelt EA MR of carcinoma-specific monoclonal antibody conjugated to monocrystalline iron oxide nanoparticles: the potential for noninvasive diagnosis. AJNR Am J Neuroradiol. 1996;17(3):411-8 - PMID: 8881233

  • Shen TT, Bogdanov A, Bogdanova A, Poss K, Brady TJ, Weissleder R Magnetically labeled secretin retains receptor affinity to pancreas acinar cells. Bioconjug Chem. 1996;7(3):311-6 - PMID: 8816953 - DOI: 10.1021/bc960003u

  • Mohr U, Weissleder R [Lymph node diagnosis with imaging methods. An overview with special reference to recent developments in the area of MR contrast media]. Z Lymphol. 1996;20(1):15-20 - PMID: 8768044

  • Weissleder R Can gadolinium be safely given in renal failure?. AJR Am J Roentgenol. 1996;167(1):278-9 - PMID: 8659405 - DOI: 10.2214/ajr.167.1.8659405

  • Bogdanov A, Weissleder R, Brady T Long-circulating blood pool imaging agents. Adv Drug Deliv Rev. 1995;15:335-348

  • Weissleder R, Bogdanov A, Neuwelt EA, Papisov M Long-circulating iron oxides for MR imaging. Adv Drug Deliv Rev. 1995;16:321-334

  • Harika L, Weissleder R, Poss K, Zimmer C, Papisov MI, Brady TJ MR lymphography with a lymphotropic T1-type MR contrast agent: Gd-DTPA-PGM. Magn Reson Med. 1995;33(1):88-92 - PMID: 7891541 - DOI: 10.1002/mrm.1910330113

  • Frank H, Weissleder R, Papisov M [Presentation and quantification of acute myocardial infarct using antibody-bound MR contrast medium]. Z Kardiol. 1995;84(4):311-5 - PMID: 7785304

  • Weissleder R, Poss K, Wilkinson R, Zhou C, Bogdanov A Quantitation of slow drug release from an implantable and degradable gentamicin conjugate by in vivo magnetic resonance imaging. Antimicrob Agents Chemother. 1995;39(4):839-45 - PMID: 7785981 - PMCID: PMC162639 - DOI: 10.1128/aac.39.4.839

  • Petropoulos AE, Schaffer BK, Cheney ML, Enochs S, Zimmer C, Weissleder R MR imaging of neuronal transport in the guinea pig facial nerve: initial findings. Acta Otolaryngol. 1995;115(4):512-6 - PMID: 7572127 - DOI: 10.3109/00016489509139358

  • Gupta H, Weissleder R, Bogdanov AA, Brady TJ Experimental gastrointestinal hemorrhage: detection with contrast-enhanced MR imaging and scintigraphy. Radiology. 1995;196(1):239-44 - PMID: 7784574 - DOI: 10.1148/radiology.196.1.7784574

  • Zimmer C, Weissleder R, O'Connor D, LaPointe L, Brady TJ, Enochs WS Cerebral iron oxide distribution: in vivo mapping with MR imaging. Radiology. 1995;196(2):521-7 - PMID: 7617871 - DOI: 10.1148/radiology.196.2.7617871

  • Schulze E, Ferrucci JT, Poss K, Lapointe L, Bogdanova A, Weissleder R Cellular uptake and trafficking of a prototypical magnetic iron oxide label in vitro. Invest Radiol. 1995;30(10):604-10 - PMID: 8557500 - DOI: 10.1097/00004424-199510000-00006

  • Zimmer C, Weissleder R, Poss K, Bogdanova A, Wright SC, Enochs WS MR imaging of phagocytosis in experimental gliomas. Radiology. 1995;197(2):533-8 - PMID: 7480707 - DOI: 10.1148/radiology.197.2.7480707

  • Gupta H, Wilkinson RA, Bogdanov AA, Callahan RJ, Weissleder R Inflammation: imaging with methoxy poly(ethylene glycol)-poly-L-lysine-DTPA, a long-circulating graft copolymer. Radiology. 1995;197(3):665-9 - PMID: 7480736 - DOI: 10.1148/radiology.197.3.7480736

  • Muldoon LL, Nilaver G, Kroll RA, Pagel MA, Breakefield XO, Chiocca EA, Davidson BL, Weissleder R, Neuwelt EA Comparison of intracerebral inoculation and osmotic blood-brain barrier disruption for delivery of adenovirus, herpesvirus, and iron oxide particles to normal rat brain. Am J Pathol. 1995;147(6):1840-51 - PMID: 7495307 - PMCID: PMC1869962

  • Rainov NG, Zimmer C, Chase M, Kramm CM, Chiocca EA, Weissleder R, Breakefield XO Selective uptake of viral and monocrystalline particles delivered intra-arterially to experimental brain neoplasms. Hum Gene Ther. 1995;6(12):1543-52 - PMID: 8664379 - DOI: 10.1089/hum.1995.6.12-1543

  • Frank H, Weissleder R, Brady TJ Enhancement of MR angiography with iron oxide: preliminary studies in whole-blood phantom and in animals. AJR Am J Roentgenol. 1994;162(1):209-13 - PMID: 8273667 - DOI: 10.2214/ajr.162.1.8273667

  • Neuwelt EA, Weissleder R, Nilaver G, Kroll RA, Roman-Goldstein S, Szumowski J, Pagel MA, Jones RS, Remsen LG, McCormick CI Delivery of virus-sized iron oxide particles to rodent CNS neurons. Neurosurgery. 1994;34(4):777-84 - PMID: 8008188 - DOI: 10.1227/00006123-199404000-00048

  • Weissleder R, Heautot JF, Schaffer BK, Nossiff N, Papisov MI, Bogdanov A, Brady TJ MR lymphography: study of a high-efficiency lymphotrophic agent. Radiology. 1994;191(1):225-30 - PMID: 8134576 - DOI: 10.1148/radiology.191.1.8134576

  • Enochs WS, Weissleder R MR imaging of the peripheral nervous system. J Magn Reson Imaging. 1994;4(3):251-7 - PMID: 7520307 - DOI: 10.1002/jmri.1880040306

  • Reimer P, Saini S, Kwong KK, Cohen MS, Weissleder R, Brady TJ Dynamic gadolinium-enhanced echo-planar MR imaging of the liver: effect of pulse sequence and dose on enhancement. J Magn Reson Imaging. 1994;4(3):331-5 - PMID: 8061430 - DOI: 10.1002/jmri.1880040318

  • Frank H, Weissleder R, Bogdanov AA, Brady TJ Detection of pulmonary emboli by using MR angiography with MPEG-PL-GdDTPA: an experimental study in rabbits. AJR Am J Roentgenol. 1994;162(5):1041-6 - PMID: 8165978 - DOI: 10.2214/ajr.162.5.8165978

  • Lu DS, Saini S, Hahn PF, Goldberg M, Lee MJ, Weissleder R, Gerard B, Halpern E, Cats A T2-weighted MR imaging of the upper part of the abdomen: should fat suppression be used routinely?. AJR Am J Roentgenol. 1994;162(5):1095-100 - PMID: 8165989 - DOI: 10.2214/ajr.162.5.8165989

  • Bogdanov AA, Martin C, Weissleder R, Brady TJ Trapping of dextran-coated colloids in liposomes by transient binding to aminophospholipid: preparation of ferrosomes. Biochim Biophys Acta. 1994;1193(1):212-8 - PMID: 7518693 - DOI: 10.1016/0005-2736(94)90350-6

  • van Everdingen KJ, Enochs WS, Bhide PG, Nossiff N, Papisov M, Bogdanov A, Brady TJ, Weissleder R Determinants of in vivo MR imaging of slow axonal transport. Radiology. 1994;193(2):485-91 - PMID: 7526413 - DOI: 10.1148/radiology.193.2.7526413

  • Bogdanov AA, Callahan RJ, Wilkinson RA, Martin C, Cameron JA, Fischman AJ, Brady TJ, Weissleder R Synthetic copolymer kit for radionuclide blood-pool imaging. J Nucl Med. 1994;35(11):1880-6 - PMID: 7965173

  • Reimer P, Weissleder R, Shen T, Knoefel WT, Brady TJ Pancreatic receptors: initial feasibility studies with a targeted contrast agent for MR imaging. Radiology. 1994;193(2):527-31 - PMID: 7972773 - DOI: 10.1148/radiology.193.2.7972773

  • Weissleder R Liver MR imaging with iron oxides: toward consensus and clinical practice. Radiology. 1994;193(3):593-5 - PMID: 7972790 - DOI: 10.1148/radiology.193.3.7972790

  • Weissleder R, Reimer P Iron oxide based magnetopharmaceuticals for MR imaging. Eur J Radiol. 1993;3:198-212

  • Schaffer BK, Linker C, Papisov M, Tsai E, Nossiff N, Shibata T, Bogdanov A, Brady TJ, Weissleder R MION-ASF: biokinetics of an MR receptor agent. Magn Reson Imaging. 1993;11(3):411-7 - PMID: 7685055 - DOI: 10.1016/0730-725x(93)90074-n

  • Weissleder R, Wang YM, Papisov M, Bogdanov A, Schaffer B, Brady TJ, Wittenberg J Polymeric contrast agents for MR imaging of adrenal glands. J Magn Reson Imaging. 1993;3(1):93-7 - PMID: 8428107 - DOI: 10.1002/jmri.1880030116

  • Shen T, Weissleder R, Papisov M, Bogdanov A, Brady TJ Monocrystalline iron oxide nanocompounds (MION): physicochemical properties. Magn Reson Med. 1993;29(5):599-604 - PMID: 8505895 - DOI: 10.1002/mrm.1910290504

  • Bogdanov AA, Weissleder R, Frank HW, Bogdanova AV, Nossif N, Schaffer BK, Tsai E, Papisov MI, Brady TJ A new macromolecule as a contrast agent for MR angiography: preparation, properties, and animal studies. Radiology. 1993;187(3):701-6 - PMID: 8497616 - DOI: 10.1148/radiology.187.3.8497616

  • Enochs WS, Schaffer B, Bhide PG, Nossiff N, Papisov M, Bogdanov A, Brady TJ, Weissleder R MR imaging of slow axonal transport in vivo. Exp Neurol. 1993;123(2):235-42 - PMID: 8405287 - DOI: 10.1006/exnr.1993.1156

  • Weissleder R, Bogdanov A, Frank H, Nossiff N, Bogdanova A, Schaffer BK, Brady T, Wittenberg J AUR Memorial Award 1993. A drug system (PDH) for interventional radiology. Synthesis, properties, and efficacy. Invest Radiol. 1993;28(12):1083-9 - PMID: 8307710 - DOI: 10.1097/00004424-199312000-00001

  • Weissleder R, Papisov M Pharmaceutical iron oxides for MR imaging. J Magn Reson Imaging. 1992;4:1-6

  • Josephson L, Groman E, Weissleder R Contrast agents for magnetic resonance imaging of the liver. Targeted Diagn Ther. 1992;4:163-87 - PMID: 1797156

  • Weissleder R, Lee AS, Khaw BA, Shen T, Brady TJ Antimyosin-labeled monocrystalline iron oxide allows detection of myocardial infarct: MR antibody imaging. Radiology. 1992;182(2):381-5 - PMID: 1732953 - DOI: 10.1148/radiology.182.2.1732953

  • Reimer P, Weissleder R, Wittenberg J, Brady TJ Receptor-directed contrast agents for MR imaging: preclinical evaluation with affinity assays. Radiology. 1992;182(2):565-9 - PMID: 1732982 - DOI: 10.1148/radiology.182.2.1732982

  • Reimer P, Kwong KK, Weisskoff R, Cohen MS, Brady TJ, Weissleder R Dynamic signal intensity changes in liver with superparamagnetic MR contrast agents. J Magn Reson Imaging. 1992;2(2):177-81 - PMID: 1562768 - DOI: 10.1002/jmri.1880020210

  • Weissleder R, Bogdanov A, Papisov M Drug targeting in magnetic resonance imaging. Magn Reson Q. 1992;8(1):55-63 - PMID: 1567758

  • Reimer P, Weissleder R, Nickeleit V, Brady TJ Animal models for magnetic resonance imaging research of the liver. Invest Radiol. 1992;27(5):390-3 - PMID: 1582824 - DOI: 10.1097/00004424-199205000-00014

  • Lee AS, Weissleder R, Brady TJ, Wittenberg J Lymph nodes: microstructural anatomy at MR imaging. Radiology. 1991;178(2):519-22 - PMID: 1987619 - DOI: 10.1148/radiology.178.2.1987619

  • Reimer P, Weissleder R, Lee AS, Buettner S, Wittenberg J, Brady TJ Asialoglycoprotein receptor function in benign liver disease: evaluation with MR imaging. Radiology. 1991;178(3):769-74 - PMID: 1994416 - DOI: 10.1148/radiology.178.3.1994416

  • Seneterre E, Weissleder R, Jaramillo D, Reimer P, Lee AS, Brady TJ, Wittenberg J Bone marrow: ultrasmall superparamagnetic iron oxide for MR imaging. Radiology. 1991;179(2):529-33 - PMID: 2014305 - DOI: 10.1148/radiology.179.2.2014305

  • Reimer P, Weissleder R, Brady TJ, Yeager AE, Baldwin BH, Tennant BC, Wittenberg J Experimental hepatocellular carcinoma: MR receptor imaging. Radiology. 1991;180(3):641-5 - PMID: 1871273 - DOI: 10.1148/radiology.180.3.1871273

  • Chew FS, Weissleder R Mediastinal thymolipoma. AJR Am J Roentgenol. 1991;157(3):468 - PMID: 1872228 - DOI: 10.2214/ajr.157.3.1872228

  • Weissleder R, Lee AS, Fischman AJ, Reimer P, Shen T, Wilkinson R, Callahan RJ, Brady TJ Polyclonal human immunoglobulin G labeled with polymeric iron oxide: antibody MR imaging. Radiology. 1991;181(1):245-9 - PMID: 1887040 - DOI: 10.1148/radiology.181.1.1887040

  • Chew FS, Weissleder R Radiation-induced osteochondroma. AJR Am J Roentgenol. 1991;157(4):792 - PMID: 1892038 - DOI: 10.2214/ajr.157.4.1892038

  • Weissleder R Target-specific superparamagnetic MR contrast agents. Magn Reson Med. 1991;22(2):209-12; discussion 213-5 - PMID: 1812348 - DOI: 10.1002/mrm.1910220209

  • Hahn PF, Stark DD, Saini S, Rummeny E, Elizondo G, Weissleder R, Wittenberg J, Ferrucci JT The differential diagnosis of ringed hepatic lesions in MR imaging. AJR Am J Roentgenol. 1990;154(2):287-90 - PMID: 2153330 - DOI: 10.2214/ajr.154.2.2153330

  • Hahn PF, Stark DD, Weissleder R, Elizondo G, Saini S, Ferrucci JT Clinical application of superparamagnetic iron oxide to MR imaging of tissue perfusion in vascular liver tumors. Radiology. 1990;174(2):361-6 - PMID: 2296646 - DOI: 10.1148/radiology.174.2.2296646

  • Elizondo G, Weissleder R, Stark DD, Guerra J, Garza J, Fretz CJ, Todd LE, Ferrucci JT Hepatic cirrhosis and hepatitis: MR imaging enhanced with superparamagnetic iron oxide. Radiology. 1990;174(3 Pt 1):797-801 - PMID: 2305063 - DOI: 10.1148/radiology.174.3.2305063

  • Weissleder R, Elizondo G, Wittenberg J, Rabito CA, Bengele HH, Josephson L Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging. Radiology. 1990;175(2):489-93 - PMID: 2326474 - DOI: 10.1148/radiology.175.2.2326474

  • Weissleder R, Elizondo G, Wittenberg J, Lee AS, Josephson L, Brady TJ Ultrasmall superparamagnetic iron oxide: an intravenous contrast agent for assessing lymph nodes with MR imaging. Radiology. 1990;175(2):494-8 - PMID: 2326475 - DOI: 10.1148/radiology.175.2.2326475

  • Hahn PF, Stark DD, Lewis JM, Saini S, Elizondo G, Weissleder R, Fretz CJ, Ferrucci JT First clinical trial of a new superparamagnetic iron oxide for use as an oral gastrointestinal contrast agent in MR imaging. Radiology. 1990;175(3):695-700 - PMID: 2343116 - DOI: 10.1148/radiology.175.3.2343116

  • Fretz CJ, Stark DD, Metz CE, Elizondo G, Weissleder R, Shen JH, Wittenberg J, Simeone J, Ferrucci JT Detection of hepatic metastases: comparison of contrast-enhanced CT, unenhanced MR imaging, and iron oxide-enhanced MR imaging. AJR Am J Roentgenol. 1990;155(4):763-70 - PMID: 2119106 - DOI: 10.2214/ajr.155.4.2119106

  • Weissleder R, Reimer P, Lee AS, Wittenberg J, Brady TJ MR receptor imaging: ultrasmall iron oxide particles targeted to asialoglycoprotein receptors. AJR Am J Roentgenol. 1990;155(6):1161-7 - PMID: 2122660 - DOI: 10.2214/ajr.155.6.2122660

  • Reimer P, Weissleder R, Lee AS, Wittenberg J, Brady TJ Receptor imaging: application to MR imaging of liver cancer. Radiology. 1990;177(3):729-34 - PMID: 2243978 - DOI: 10.1148/radiology.177.3.2243978

  • Riojas GE, Weissleder R, Gonzalez HG, Miguel MC, Riojas AE, Morantes JG, Perez LET Physical principles of magnetic resonance imaging. Rev Mex Radiol. 1989;43:3-12

  • Weissleder R, Stark DD, Elizondo G, Hahn PF, Compton C, Saini S, Wittenberg J, Ferrucci JT MRI of hepatic lymphoma. Magn Reson Imaging. 1989;6(6):675-81 - PMID: 3062298 - DOI: 10.1016/0730-725x(88)90092-6

  • Rummeny E, Weissleder R, Stark DD, Saini S, Compton CC, Bennett W, Hahn PF, Wittenberg J, Malt RA, Ferrucci JT Primary liver tumors: diagnosis by MR imaging. AJR Am J Roentgenol. 1989;152(1):63-72 - PMID: 2535770 - DOI: 10.2214/ajr.152.1.63

  • Weissleder R, Stark DD, Engelstad BL, Bacon BR, Compton CC, White DL, Jacobs P, Lewis J Superparamagnetic iron oxide: pharmacokinetics and toxicity. AJR Am J Roentgenol. 1989;152(1):167-73 - PMID: 2783272 - DOI: 10.2214/ajr.152.1.167

  • Weissleder R, Elizondo G, Stark DD, Hahn PF, Marfil J, Gonzalez JF, Saini S, Todd LE, Ferrucci JT The diagnosis of splenic lymphoma by MR imaging: value of superparamagnetic iron oxide. AJR Am J Roentgenol. 1989;152(1):175-80 - PMID: 2783273 - DOI: 10.2214/ajr.152.1.175

  • Chen MC, Tsang YM, Stark DD, Weissleder R, Saini S, Brandhorst J, White DL, Engelstad BL, Ferrucci JT Hepatic metastases: rat models for imaging research. Magn Reson Imaging. 1989;7(1):1-8 - PMID: 2918813 - DOI: 10.1016/0730-725x(89)90318-4

  • Weissleder R, Stark DD Magnetic resonance imaging of liver tumors. Semin Ultrasound CT MR. 1989;10(1):63-77 - PMID: 2560665

  • Weissleder H, Weissleder R Interstitial lymphangiography: initial clinical experience with a dimeric nonionic contrast agent. Radiology. 1989;170(2):371-4 - PMID: 2911660 - DOI: 10.1148/radiology.170.2.2911660

  • Rummeny E, Saini S, Wittenberg J, Compton C, Hahn PF, Mueller PR, Simeone JF, Stark DD, Weissleder R, Dousset MG MR imaging of liver neoplasms. AJR Am J Roentgenol. 1989;152(3):493-9 - PMID: 2536996 - DOI: 10.2214/ajr.152.3.493

  • Weissleder R, Stark DD Magnetic resonance imaging of the liver. Magn Reson Q. 1989;5(2):97-121 - PMID: 2701280

  • Rummeny E, Weissleder R, Sironi S, Stark DD, Comptom CC, Hahn PF, Saini S, Wittenberg J, Ferrucci JT Central scars in primary liver tumors: MR features, specificity, and pathologic correlation. Radiology. 1989;171(2):323-6 - PMID: 2539605 - DOI: 10.1148/radiology.171.2.2539605

  • Dousset M, Weissleder R, Hendrick RE, Stark DD, Fretz CJ, Elizondo G, Hahn PF, Saini S, Ferrucci JT Short TI inversion-recovery imaging of the liver: pulse-sequence optimization and comparison with spin-echo imaging. Radiology. 1989;171(2):327-33 - PMID: 2704797 - DOI: 10.1148/radiology.171.2.2704797

  • Weissleder R, Elizondo G, Josephson L, Compton CC, Fretz CJ, Stark DD, Ferrucci JT Experimental lymph node metastases: enhanced detection with MR lymphography. Radiology. 1989;171(3):835-9 - PMID: 2717761 - DOI: 10.1148/radiology.171.3.2717761

  • Weissleder R, Thrall JH The lymphatic system: diagnostic imaging studies. Radiology. 1989;172(2):315-7 - PMID: 2748809 - DOI: 10.1148/radiology.172.2.2748809

  • Fretz CJ, Elizondo G, Weissleder R, Hahn PF, Stark DD, Ferrucci JT Superparamagnetic iron oxide-enhanced MR imaging: pulse sequence optimization for detection of liver cancer. Radiology. 1989;172(2):393-7 - PMID: 2748820 - DOI: 10.1148/radiology.172.2.2748820

  • Rummeny E, Saini S, Stark DD, Weissleder R, Compton CC, Ferrucci JT Detection of hepatic metastases with MR imaging: spin-echo vs phase-contrast pulse sequences at 0.6 T. AJR Am J Roentgenol. 1989;153(6):1207-11 - PMID: 2683677 - DOI: 10.2214/ajr.153.6.1207

  • Weissleder R, Galarza DA, Garza MA Lupus nephritis: classification, clinical features, and treatment. 1988;39(3):263-76 - PMID: 3324251

  • Weissleder R, Saini S, Stark DD, Elizondo G, Compton C, Wittenberg J, Ferrucci JT Pyogenic liver abscess: contrast-enhanced MR imaging in rats. 1988;150(1):115-20 - PMID: 3257107 - DOI: 10.2214/ajr.150.1.115

  • Weissleder R, Stark DD, Rummeny EJ, Compton CC, Ferrucci JT Splenic lymphoma: ferrite-enhanced MR imaging in rats. Radiology. 1988;166(2):423-30 - PMID: 3336717 - DOI: 10.1148/radiology.166.2.3336717

  • Weissleder R, Saini S, Stark DD, Wittenberg J, Ferrucci JT Dual-contrast MR imaging of liver cancer in rats. AJR Am J Roentgenol. 1988;150(3):561-6 - PMID: 3257610 - DOI: 10.2214/ajr.150.3.561

  • Hahn PF, Weissleder R, Stark DD, Saini S, Elizondo G, Ferrucci JT MR imaging of focal splenic tumors. AJR Am J Roentgenol. 1988;150(4):823-7 - PMID: 3279735 - DOI: 10.2214/ajr.150.4.823

  • Tsang YM, Stark DD, Chen MC, Weissleder R, Wittenberg J, Ferrucci JT Hepatic micrometastases in the rat: ferrite-enhanced MR imaging. Radiology. 1988;167(1):21-4 - PMID: 3347724 - DOI: 10.1148/radiology.167.1.3347724

  • Weissleder R, Stark DD, Compton CC, Simeone JF, Ferrucci JT Cholecystitis: diagnosis by MR imaging. Magn Reson Imaging. 1988;6(3):345-8 - PMID: 3398743 - DOI: 10.1016/0730-725x(88)90412-2

  • Weissleder H, Weissleder R Lymphedema: evaluation of qualitative and quantitative lymphoscintigraphy in 238 patients. Radiology. 1988;167(3):729-35 - PMID: 3363131 - DOI: 10.1148/radiology.167.3.3363131

  • Wittenberg J, Stark DD, Forman BH, Hahn PF, Saini S, Weissleder R, Rummeny E, Ferrucci JT Differentiation of hepatic metastases from hepatic hemangiomas and cysts by using MR imaging. AJR Am J Roentgenol. 1988;151(1):79-84 - PMID: 3259825 - DOI: 10.2214/ajr.151.1.79

  • Rummeny E, Weissleder R, Stark DD, Elizondo G, Ferrucci JT [Magnetic resonance tomography of focal liver and spleen lesions. Experiences using ferrite, a new RES-specific MR contrast medium]. Radiologe. 1988;28(8):380-6 - PMID: 3174975

  • Stark DD, Weissleder R, Elizondo G, Hahn PF, Saini S, Todd LE, Wittenberg J, Ferrucci JT Superparamagnetic iron oxide: clinical application as a contrast agent for MR imaging of the liver. Radiology. 1988;168(2):297-301 - PMID: 3393649 - DOI: 10.1148/radiology.168.2.3393649

  • Weissleder R, Hahn PF, Stark DD, Elizondo G, Saini S, Todd LE, Wittenberg J, Ferrucci JT Superparamagnetic iron oxide: enhanced detection of focal splenic tumors with MR imaging. Radiology. 1988;169(2):399-403 - PMID: 3174987 - DOI: 10.1148/radiology.169.2.3174987

  • Weissleder R, Galarza D, Garza MA Lupus nephritis: Classification, clinical features and treatment. Rev Invest Clin. 1987;39:263-276

  • Weissleder R, Marfil A, Martinez HR, Rangel-Guerra RA Limb girdle type muscular dystrophy associated with a Wolff-Parkinson-White syndrome. J Neurol Neurosurg Psych. 1987;50(4):500-1 - PMID: 3585373 - PMCID: PMC1031899 - DOI: 10.1136/jnnp.50.4.500

  • Weissleder R, Elizondo G, Stark DD Sonographic diagnosis of subclavian and internal jugular vein thrombosis. J Ultrasound Med. 1987;6(10):577-87 - PMID: 3316690 - DOI: 10.7863/jum.1987.6.10.577

  • Weissleder R, Hahn PF, Stark DD, Rummeny E, Saini S, Wittenberg J, Ferrucci JT MR imaging of splenic metastases: ferrite-enhanced detection in rats. AJR Am J Roentgenol. 1987;149(4):723-6 - PMID: 3498320 - DOI: 10.2214/ajr.149.4.723

  • Elizondo G, Weissleder R, Stark DD, Todd LE, Compton C, Wittenberg J, Ferrucci JT Amebic liver abscess: diagnosis and treatment evaluation with MR imaging. Radiology. 1987;165(3):795-800 - PMID: 2891154 - DOI: 10.1148/radiology.165.3.2891154

  • Weissleder R, Stark DD, Compton CC, Wittenberg J, Ferrucci JT Ferrite-enhanced MR imaging of hepatic lymphoma: an experimental study in rats. 1987;149(6):1161-5 - PMID: 3318339 - DOI: 10.2214/ajr.149.6.1161

  • Weissleder R, Bauer M After loading therapy with Cs-137 for cervical cancer: Evaluation of the first 117 patients treated. 1986;32:147-153