Aguirre Lab
Read BioMy laboratory is both at the Center for Systems Biology at MGH and the Wellman Center for Photomedicine. We are also closely affiliated with the MGH Cardiovascular Research Center. We both develop and apply innovative molecular imaging and advanced microscopy technologies to investigate the pathophysiology of myocardial infarction, heart failure, and circulatory shock. We have pioneered the use of cardiac intravital microscopy to study the beating heart at cellular resolution in animal models and have explored multiple applications of this technology.
Example projects using in the lab currently include 1) investigation of the remodeling and regulation of the coronary microcirculation in heart failure and 2) mapping of cardiac arrhythmia at the cellular scale using intravital microscopy. In addition, our laboratory studies acute decompensated heart failure and shock in human patients using data from the cardiac intensive care units at the MGH. We work in collaboration with investigators at the MGH Clinical Data Animation Center and at MIT on projects aimed at developing novel clinical diagnostics and predictive analytics for circulatory shock and cardiac arrest. Our work has been funded by the National Institutes of Health, the American Heart Association, and CRICO.
Recent Publications
Chandrasekhar A, Padrós-Valls R, Pallarès-López R, Palanques-Tost E, Houstis N, Sundt TM, Lee HS, Sodini CG, Aguirre AD Tissue perfusion pressure enables continuous hemodynamic evaluation and risk prediction in the intensive care unit. Nat Med. 2023;29(8):1998-2006 - PMID: 37550417 - DOI: 10.1038/s41591-023-02474-6
Zeller MWG, Wang C, Keliher EJ, Wojtkiewicz GR, Aguirre A, Maresca K, Su C, Buckbinder L, Wang J, Nahrendorf M, Chen JW Myeloperoxidase PET Imaging Tracks Intracellular and Extracellular Treatment Changes in Experimental Myocardial Infarction. Int J Mol Sci. 2023;24(6):ePub - PMID: 36982778 - PMCID: PMC10057533 - DOI: 10.3390/ijms24065704
Foy BH, Sundt TM, Carlson JCT, Aguirre AD, Higgins JM Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations. Nat Commun. 2022;13(1):4705 - PMID: 35995789 - PMCID: PMC9395541 - DOI: 10.1038/s41467-022-32222-2
Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi SL, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J, Shiau C, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco MS, Nguyen L, Delorey T, Phillips D, Barth JL, Kem M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgji V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem JM, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Castillo CF, Liss AS, Ting DT, Jacks T, Regev A Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment. Nat Genet. 2022;54(8):1178-1191 - PMID: 35902743 - PMCID: PMC10290535 - DOI: 10.1038/s41588-022-01134-8 - Cover
Grune J, Lewis AJM, Yamazoe M, Hulsmans M, Rohde D, Xiao L, Zhang S, Ott C, Calcagno DM, Zhou Y, Timm K, Shanmuganathan M, Pulous FE, Schloss MJ, Foy BH, Capen D, Vinegoni C, Wojtkiewicz GR, Iwamoto I, Grune T, Brown D, Higgins J, Ferreira VM, Herring N, Channon KM, Neubauer S, Oxford Acute Myocardial Infarction (OxAMI) Study, Sosnovik DE, Milan DJ, Swirski FK, King KR, Aguirre AD, Ellinor PT, Nahrendorf M Neutrophils incite and macrophages avert electrical storm after myocardial infarction. Nat Cardiovasc Res. 2022;1(7):649-664 - PMID: 36034743 - PMCID: PMC9410341 - DOI: 10.1038/s44161-022-00094-w
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