My laboratory is both at the Center for Systems Biology at MGH and the Wellman Center for Photomedicine. We are also closely affiliated with the MGH Cardiovascular Research Center. We both develop and apply innovative molecular imaging and advanced microscopy technologies to investigate the pathophysiology of myocardial infarction, heart failure, and circulatory shock. We have pioneered the use of cardiac intravital microscopy to study the beating heart at cellular resolution in animal models and have explored multiple applications of this technology.
Example projects using in the lab currently include 1) investigation of the remodeling and regulation of the coronary microcirculation in heart failure and 2) mapping of cardiac arrhythmia at the cellular scale using intravital microscopy. In addition, our laboratory studies acute decompensated heart failure and shock in human patients using data from the cardiac intensive care units at the MGH. We work in collaboration with investigators at the MGH Clinical Data Animation Center and at MIT on projects aimed at developing novel clinical diagnostics and predictive analytics for circulatory shock and cardiac arrest. Our work has been funded by the National Institutes of Health, the American Heart Association, and CRICO.
Aguirre AD, Arbab-Zadeh A, Soeda T, Fuster V, Jang IK Optical Coherence Tomography of Plaque Vulnerability and Rupture: JACC Focus Seminar Part 1/3. J Am Coll Cardiol. 2021;78(12):1257-1265 - PMID: 34531027
Ong CS, Reinertsen E, Sun H, Moonsamy P, Mohan N, Funamoto M, Kaneko T, Shekar PS, Schena S, Lawton JS, D'Alessandro DA, Westover MB, Aguirre AD, Sundt TM Prediction of operative mortality for patients undergoing cardiac surgical procedures without established risk scores. J Thorac Cardiovasc Surg. 2021;:ePub - PMID: 34607725
Calcagno DM, Zhang C, Toomu A, Huang K, Ninh VK, Miyamoto S, Aguirre AD, Fu Z, Heller Brown J, King KR SiglecF(HI) Marks Late-Stage Neutrophils of the Infarcted Heart: A Single-Cell Transcriptomic Analysis of Neutrophil Diversification. J Am Heart Assoc. 2021;10(4):e019019 - PMID: 33525909 - PMCID: PMC7955351 - DOI: 10.1161/JAHA.120.019019
Nahrendorf M, Hoyer FF, Meerwaldt AE, van Leent MMT, Senders ML, Calcagno C, Robson PM, Soultanidis G, Pérez-Medina C, Teunissen AJP, Toner YC, Ishikawa K, Fish K, Sakurai K, van Leeuwen EM, Klein ED, Sofias AM, Reiner T, Rohde D, Aguirre AD, Wojtkiewicz G, Schmidt S, Iwamoto Y, Izquierdo-Garcia D, Caravan P, Swirski FK, Weissleder R, Mulder WJM Imaging Cardiovascular and Lung Macrophages With the Positron Emission Tomography Sensor 64Cu-Macrin in Mice, Rabbits, and Pigs. Circ Cardiovasc Imaging. 2020;13(10):e010586 - PMID: 33076700 - PMCID: PMC7583675 - DOI: 10.1161/CIRCIMAGING.120.010586
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