Aguirre Lab
Read BioMy laboratory is both at the Center for Systems Biology at MGH and the Wellman Center for Photomedicine. We are also closely affiliated with the MGH Cardiovascular Research Center. We both develop and apply innovative molecular imaging and advanced microscopy technologies to investigate the pathophysiology of myocardial infarction, heart failure, and circulatory shock. We have pioneered the use of cardiac intravital microscopy to study the beating heart at cellular resolution in animal models and have explored multiple applications of this technology.
Example projects using in the lab currently include 1) investigation of the remodeling and regulation of the coronary microcirculation in heart failure and 2) mapping of cardiac arrhythmia at the cellular scale using intravital microscopy. In addition, our laboratory studies acute decompensated heart failure and shock in human patients using data from the cardiac intensive care units at the MGH. We work in collaboration with investigators at the MGH Clinical Data Animation Center and at MIT on projects aimed at developing novel clinical diagnostics and predictive analytics for circulatory shock and cardiac arrest. Our work has been funded by the National Institutes of Health, the American Heart Association, and CRICO.
Recent Publications
Haimovich JS, Kolossváry M, Alam R, Padrós-Valls R, Lu MT, Aguirre AD
Risk stratification of chest pain in the emergency department using artificial intelligence applied to electrocardiograms. Open Heart. 2025;12(2):ePub - PMID: 40889954 - PMCID: PMC12406858 - DOI: 10.1136/openhrt-2025-003343Ayers BC, Olverson G, Chukwudi C, Higuita ML, Ajenu E, Bolger-Chen M, Catricala J, Pitti A, Moshe YK, Kang J, Aguirre AD, Sundt TM, Michel E, Osho A, Tessier SN, Alireza Rabi S, D'Alessandro D
Video kinematics of an unloaded, ex-vivo beating heart can predict future loaded heart function. J Heart Lung Transplant. 2025;44(11):1823-1826 - PMID: 40716473 - DOI: 10.1016/j.healun.2025.07.023Ayers BC, Aguirre AD, Sundt TM, Lu MT, Jassar A
An open-source, automated machine learning approach for large-scale image retrieval for thoracic aorta analysis studies. JAMIA Open. 2025;8(4):ooaf066 - PMID: 40662082 - PMCID: PMC12257624 - DOI: 10.1093/jamiaopen/ooaf066Li J, Aguirre AD, Moura V, Jin J, Liu C, Zhong L, Sun C, Clifford G, Westover MB, Hong S
An Electrocardiogram Foundation Model Built on over 10 Million Recordings. NEJM AI. 2025;2(7):ePub - PMID: 40771651 - PMCID: PMC12327759 - DOI: 10.1056/aioa2401033Palanques-Tost E, Pallarès-López R, Padrós-Valls R, Song S, Reinertsen E, Churchill TW, Stockwell P, Pomerantsev E, Garasic J, Sundt TM, Shah P, Houstis NE, Aguirre AD
Cardiac Output Estimation in the Intensive Care Unit. JACC Adv. 2025;4(5):101663 - PMID: 40286350 - PMCID: PMC12101535 - DOI: 10.1016/j.jacadv.2025.101663- More publications ...