Research Highlights (more...)

  • Epr

    Are nanomedicines right for you?

    Nanoparticles promise to deliver toxic chemotherapeutics more safely and efficiently to solid tumors, but clinical responses to such treatments have been mixed: some patients respond extremely well while others do not. Using advanced imaging techniques, researchers at CSB have discovered a way to repurpose FDA-approved magnetic nanoparticles for predicting how effectively nanomedicines can accumulate in tumors. Published in Science Translational Medicine, this “companion diagnostic" approach suggests that clinical imaging can be used to select patients most likely to benefit from the most advanced nanomedicine treatments.

  • Tam

    Macrophages act as drug delivery depots of nanomedicines

    Solid tumors often contain large numbers of immune cells including macrophages that feed cancer growth and metastasis. CSB researchers discovered that these tumor associated macrophages can be co-opted by nanomaterials to serve as drug depots, gradually delivering chemotherapy to neighboring cancer cells. Driven by new intravital imaging technology and published in Nature Communications, this research presents a new paradigm for therapeutic design and for selecting patients into clinical trials.

  • Stem_cells

    Bone marrow stem cells are alerted to heart attack

    Blood cells, including inflammatory monocytes, are made in the bone marrow and ultimately derive from hematopoietic stem cells. Until now it was unknown which bone marrow cells expand in acute myocardial infarction. Recent work published in Cell Stem Cell identified a subpopulation of short-term stem cells as the most upstream activation point after MI. The surface marker CCR2 identifies, in mice and in humans, the cell subset that sit almost at the very top of the hematopoietic tree as particularly responsive to an injury of the heart. The myeloid translocation gene 16 regulates their emergence, and may provide a therapeutic target to dampen leukocyte production that could otherwise jeopardize resolution of inflammatory activity in cardiovascular organs.

  • D3

    Smartphone Sees Cancer

    With their ubiquitous presence and superb computation power, smartphones now bring unprecedented opportunities to realize mobile healthcare. Reported in PNAS, CSB researchers have developed a new smartphone-based system, D3 (digital diffraction diagnosis), for on-the-spot molecular detection. This system, complete with a custom App, was used for cervical cancer screen and diagnosing aggressive lymphomas, prevalent cancers in low and middle-income countries.

  • Sepsis

    A new lead in solving sepsis

    The complication of an infection known as sepsis (or “blood poisoning”) is extremely dangerous, claiming up to half a million lives in the United States every year. A study from the Swirski lab has shown that a growth factor called interleukin-3 (IL-3) amplifies inflammation in sepsis and potentiates septic shock, the most severe form of sepsis. The authors show that IL-3 induces the emergency production of inflammatory monocytes and neutrophils, which are sources of the hallmark cytokines that comprise a lethal cytokine storm. A subset of B-1 B cells, discovered in the Swirski lab and named IRA B cells, are abundant sources of IL-3 in sepsis. Patients diagnosed with sepsis with high IL-3 in their blood die more often than those containing low IL-3. The findings are reported in the March 13th issue of Science.

  • Eribulin

    When our drugs don't work.

    Eribulin was developed as a potent anticancer agent, but it fails in many patients for unknown reasons. In a recent study, CSB researchers used microscopic imaging in tumors to show that resistance is primarily due to MDR1-mediated drug efflux. It was discovered that a new nano-encapsulated MDR1 inhibitor was able to restore drug efficacy. These studies show that in vivo imaging is a powerful strategy for elucidating mechanisms of drug resistance in heterogeneous tumors and for evaluating strategies to overcome this resistance.

  • Stress

    Stem cells get stressed out too!

    For decades, doctors knew that chronic stress is bad for you. The study by Heidt and Sager found that psychosocial stress activates bone marrow stem cells, which in turn triggers overproduction of inflammatory leukocytes, including neutrophils and monocytes. These leukocytes are more numerous in blood and accumulate in atherosclerotic lesions, putting the individual at higher risk for myocardial infarction and stroke.

  • Nanoholes

    Tiny holes enable big measurements

    A new technology developed at CSB allows profiling of small subcellular structures such as exosomes. The technology uses tiny gold grids studded with nanoholes in array format. Each of the holes has been modified with different antibodies. Biomarkers interacting with these tiny nano holes change the light properties (nano-plasmons), an effect which can optically detected. This technology (”nPLEX”) will allow high-throughput analysis of a number of clinically important biomarkers.

  • Dna_barcode

    More (proteomic) bang-for-your-buck

    Extracting maximal information from minimal, easily acquired samples is the holy grail for patient monitoring in clinical trials. A new technology developed at the CSB, holds promise for revolutionizing clinical monitoring by allowing vast amounts of proteomic information to be obtained from minute samples.

  • Ascites_1

    Repurposing often discarded ascites

    Buildup of cancer-containing fluid in the abdomen (ascites) is a common occurrence suffered by many patients with advanced malignancies. Researchers have developed and tested a novel microfluidic chip, reported in PNAS, to selectively detect ascites tumor cells and enable further testing. This approach seeks to repurpose ascites for serial pharmacodynamic readouts.

  • Plaque_sm

    Proliferation rules

    According to a recent study by CSB researchers, the primary driver of atherosclerotic plaque growth is local proliferation of plaque-resident inflammatory cells. This finding not only challenges previous assumptions that plaque growth is the exclusive result of cell recruitment from the blood, but now raises hope for the future development of targeted atherosclerotic treatment. Findings are reported in Nature Medicine.

  • Bact

    Cracking bacterial code for quick diagnosis

    Researchers have developed a quick and sensitive method for identifying and characterizing infectious bacteria in patient samples. The genetic test uses specially designed DNA probes that seek out and magnetically label regions of bacterial RNA. Reported in Nature Nanotechnology, this diagnostic technique is powerful enough to detect and differentiate single bacteria in under 2 hours.

  • Device_med

    Faster cheaper TB diagnosis

    A nanotechnology inspired genetic test has been developed to detect tuberculosis (TB) directly in sputum. The method not only distinguishes different forms of TB but also sheds light on drug resistant strains. The innovative device, described in Nature Communications, is also capable of comprehensive diagnosis in two hours and is sensitive enough to detect single bacteria.

  • Exosome3

    The magic of “cell dust”

    A novel diagnostic platform has been shown capable of detecting minuscule particles shed by cells, known as microvesicles, in a drop of blood. In a groundbreaking study, published in Nature Medicine, we demonstrate that by using nanotechnology together with nuclear magnetic resonance (NMR), microvesicles shed by brain cancer cells can be reliably detected in human blood samples.

  • Beating_heart

    Imaging the beating heart in the living body

    Imaging individual cells in a live beating heart has been nearly impossible. Yet, this would offer unprecedented opportunities to better understand heart diseases. A new imaging method - reported in the October issue of Nature Communications - and developed by researchers at the Center for System Biology now allows single cell resolution imaging in cardiovascular research.

  • Ctcs

    Finding a needle in a haystack

    Researchers have developed a novel microchip that can rapidly scan through the enormous number of cells in a blood sample to find very rare circulating tumor cells. Using a combination of microelectronics, microfluidics, and nanotechnology, this new system, described in the July issue of Science Translational Medicine, now has the potential for rapid and accurate on-the-spot cancer diagnosis and treatment monitoring.

  • Athero

    Not just a ‘plumbing’ disease

    New research at the Center for Systems Biology (CSB) has shown that heart attacks are not just a “plumbing” problem in the arteries but a ‘whole system’ condition, resulting in widespread inflammation and a predisposition for a secondary attack.

  • Sicklecells4

    Sickle symptoms linked to cell flow

    The genetic abnormality that causes blood cells to deform and clog vessels in sickle cell disease results in wide symptom variability across patients. Until now, there has been no way to distinguish patients with severe from patients with mild disease. A novel technique, however, has shown promise in differentiating patients based on the rate at which their blood stops flowing under low oxygen.

  • Ira_cell

    A new cell discovered

    Sepsis is a life-threatening condition characterized by whole-body inflammation to overwhelming infection. A newly discovered cell type known as “innate response activator” has been found to protect against sepsis. This discovery will likely provide insight into the development of sepsis and potentially lead to new avenues for therapeutic intervention.

  • Fourescent_small

    Novel therapy turns off navigation system in disease-promoting cells

    By manipulating the molecular navigation system used by inflammatory immune cells to reach sites of tissue damage, researchers at the Center for Systems Biology may have struck upon an effective novel anti-inflammatory treatment. Given that inflammation is an exacerbator of almost all major diseases, this therapy could potentially have wide-spread benefit.

  • Probing_the_heart_for_infection

    Probing the heart for infection

    A new imaging probe developed by researchers at the Center for Systems Biology can detect acute endocarditis, a rapidly progressing infection of the heart valves. This imaging agent binds tightly to a product released by the most deadly cause of the infection-Staphylococcus aureus-rendering it visible by both optical and PET imaging. Ultimately, the agent could be used to rapidly diagnose, and thus treat, this potentially fatal condition.

  • Spleen

    The spleen's newly discovered function

    While the spleen has long held a reputation for redundancy, recent research has now shown that quite the opposite is true. The spleen, in fact, appears to play an important role in the repair of tissue. Mikael Pittet, one of the four lead investigators responsible for this finding, discusses this work and its possible implications.

  • Glow

    Glow-in-the-dark plaques

    Finding new uses for already FDA approved drugs is a speedy way of translating new biological discoveries into patient benefit. Using a novel catheter-based imaging system, the fluorescent dye Indocyanine green has been shown capable of highlighting the culprits responsible for strokes and heart attacks, namely inflamed arterial plaques.

  • Cell_gray

    When small meets speedy...

    In today's fast paced world, waiting for anything is often frustrating and stressful. But few delays can be worse than that following a diagnostic blood test or biopsy, where results can take days to come back. Recently, a new portable device, known as DMR has been shown capable of on the spot cancer diagnosis.

The MGH Center for Systems Biology (CSB) was established as one of the five thematic interdisciplinary Centers at MGH. It is home to over 200 researchers in 12 PI groups. The mission of the Center is to analyze at a systems level how biological molecules, proteins and cells interact in both healthy and diseased states.

Through a multidisciplinary approach that combines clinical insight with powerful technologies, CSB faculty pursue systems-level research that is at once fundamental, and yet immediately linked to the diagnosis and treatment of human disease. While these approaches are generalizable to many diseases, the Center has particular strengths in complex human conditions such as cancer, cardiovascular disease, diabetes, autoimmune disease, and renal disease. This goal is enabled by particular faculty expertise in genomics, chemical biology, physiology, bioimaging, and nanotechnology.

The Center has close links with the HMS Department of Systems Biology, clinical departments at MGH, other MGH thematic centers, MIT, and the Broad Institute.

Recent Publications (more...)

Ramasamy S, Saez B, Mukhopadhyay S, Ding D, Ahmed AM, Chen X, Pucci F, Yamin R, Wang J, Pittet MJ, Kelleher CM, Scadden DT, Sweetser DA
Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway.
Proc Natl Acad Sci U S A. 2016;:ePub - PMID: 26831087
Drier Y, Cotton MJ, Williamson KE, Gillespie SM, Ryan RJ, Kluk MJ, Carey CD, Rodig SJ, Sholl LM, Afrogheh AH, Faquin WC, Queimado L, Qi J, Wick MJ, El-Naggar AK, Bradner JE, Moskaluk CA, Aster JC, Knoechel B, Bernstein BE
An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma.
Nat Genet. 2016;:ePub - PMID: 26829750
Jeong S, Park J, Pathania D, Castro CM, Weissleder R, Lee H
Integrated Magneto-Electrochemical Sensor for Exosome Analysis.
ACS Nano. 2016;:ePub - PMID: 26808216
Calcagno C, Mulder WJ, Nahrendorf M, Fayad ZA
Systems Biology and Noninvasive Imaging of Atherosclerosis.
Arterioscler Thromb Vasc Biol. 2016;36(2):e1-8 - PMID: 26819466

Recent News (more...)

2015-12-30: Filip Swirski, PhD is the recipient of the 2016 MGH Martin Prize for Fundamental Research. Congratulations, Fil!
2015-12-02: Memorial Sloan Kettering has named Bradley E. Bernstein as a recipient of this year’s Paul Marks Prize for Cancer Research. The award recognizes promising investigators aged 45 or younger for their efforts in advancing cancer research. Congratulations, Brad!
2015-10-20: Kevin King was recently selected as a finalist in the Northwestern Cardiovascular Young Investigator's Forum. His project won the 1st place Fellow's Basic Science.
2015-09-28: Roy Malka from the Higgins Lab, has won the prize for best MGH Pathology poster from a resident or fellow this year for his abstract entitled “Patient-Specific Inference of Average Glucose from Glycated Hemoglobin: Toward Personalized Diabetic Monitoring with Precision Laboratory Medicine”. Congratulations, Roy!
2015-09-24: Dong-Eog Kim (Dongguk University, Seoul) and Matthias Nahrendorf received the “Global Research Lab” award from the Korean government, an initiative that integrates US and Korean scientists.

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