Novel immune checkpoint blockade therapies can be extraordinarily effective but may benefit only the minority of patients whose tumors are pre-infiltrated by antitumor immune cells called CD8+ T cells. In a study published in Immunity, the Pittet lab at MGH Center for Systems Biology reports that rationally selected immunogenic chemotherapy can convert tumor microenvironments lacking T cells into ones displaying antitumor T cell immunity. This process makes unresponsive tumors sensitive to immune checkpoint blockade therapies and consequently raises hope to feasibly expand the proportion of human cancers responding to these therapies.
The MGH Center for Systems Biology (CSB) was established as one of the five
thematic interdisciplinary Centers
at MGH. It is home to over 200 researchers in 12 PI groups. The mission of the Center is to analyze at a systems level how biological molecules, proteins and cells interact in both healthy and diseased states.
Through a multidisciplinary approach that combines clinical insight with powerful technologies, CSB faculty pursue systems-level research that is at once fundamental, and yet immediately linked to the diagnosis and treatment of human disease. While these approaches are generalizable to many diseases, the Center has particular strengths in complex human conditions such as cancer, cardiovascular disease, diabetes, autoimmune disease, and renal disease. This goal is enabled by particular faculty expertise in genomics, chemical biology, physiology, bioimaging, and nanotechnology.
The Center has close links with the HMS Department of Systems Biology, clinical departments at MGH, other MGH thematic centers, MIT, and the Broad Institute.
Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging.
Nat Commun. 2016;7:10666 - PMID: 26868824
Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy
Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway.
Proc Natl Acad Sci U S A. 2016;:ePub - PMID: 26831087
Macrophage IκB Kinase α Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival, and Decreases Early Atherosclerosis.
Arterioscler Thromb Vasc Biol. 2016;:ePub - PMID: 26848161
2016-02-11: Dennis Brown, PhD
, Professor of Medicine and Director of the MGH Program in Membrane Biology, part of the Division of Nephrology and the Center for Systems Biology, was elected by a poll of its members as the new President Elect of the American Physiological Society (APS)
. Established in 1887, the American Physiological Society (APS) was the first U.S. society in the biomedical sciences field. The Society represents more than 11,000 members and publishes 14 peer-reviewed journals with a worldwide readership.
2015-10-20: Kevin King was recently selected as a finalist in the Northwestern Cardiovascular Young Investigator's Forum. His project won the 1st place Fellow's Basic Science.
Roy Malka from the Higgins Lab
, has won the prize for best MGH Pathology poster from a resident or fellow this year for his abstract entitled “Patient-Specific Inference of Average Glucose from Glycated Hemoglobin: Toward Personalized Diabetic Monitoring with Precision Laboratory Medicine”. Congratulations, Roy!