Eribulin was developed as a potent anticancer agent, but it fails in many patients for unknown reasons. In a recent study, CSB researchers used microscopic imaging in tumors to show that resistance is primarily due to MDR1-mediated drug efflux. It was discovered that a new nano-encapsulated MDR1 inhibitor was able to restore drug efficacy. These studies show that in vivo imaging is a powerful strategy for elucidating mechanisms of drug resistance in heterogeneous tumors and for evaluating strategies to overcome this resistance.
The MGH Center for Systems Biology (CSB) was established as one of the five
thematic interdisciplinary Centers
at MGH. It is home to over 200 researchers in 12 PI groups. The mission of the Center is to analyze at a systems level how biological molecules, proteins and cells interact in both healthy and diseased states.
Through a multidisciplinary approach that combines clinical insight with powerful technologies, CSB faculty pursue systems-level research that is at once fundamental, and yet immediately linked to the diagnosis and treatment of human disease. While these approaches are generalizable to many diseases, the Center has particular strengths in complex human conditions such as cancer, cardiovascular disease, diabetes, autoimmune disease, and renal disease. This goal is enabled by particular faculty expertise in genomics, chemical biology, physiology, bioimaging, and nanotechnology.
The Center has close links with the HMS Department of Systems Biology, clinical departments at MGH, other MGH thematic centers, MIT, and the Broad Institute.
Acoustic Purification of Extracellular Microvesicles.
Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients
Proc Natl Acad Sci U S A. 2015;112(7):2139-44 - PMID: 25650428
Integrative analysis of 111 reference human epigenomes.
Nature. 2015;518(7539):317-30 - PMID: 25693563
Modulation of Red Blood Cell Population Dynamics is a Fundamental Homeostatic Response to Disease.
Am J Hematol. 2015;:ePub - PMID: 25691355
2014-11-17: Kisoo Park and Jongmin Park were awarded with the prestigious post-doctoral research fellowship from National Research Foundation, Korea. Congratulations!
A multidisciplinary team lead by Dr. Herbert Y. Lin
and including CSB members Dr. Dennis Ausiello, Dr. Stanley Shaw, and Dr. Ravi Thadhani, Chief of Nephrology, working with Professor Michael Cima of the MIT Dept. of Materials Science and Engineering, have won a MGH-MIT Strategic Partnership Grand Challenge
in Diagnostics larger grant. The award will support the development of a portable, noninvasive device capable of accurately measuring blood volume using nuclear magnetic resonance (NMR). In addition, Dr. Lin is a Co-Investigator on a winning smaller grant lead by Dr. Anthony Samir of the Department of Radiology for the adaptation of an optical system for localizing the position of ultrasound transducers, which compensates for individual operator differences, to the noninvasive monitoring of tissue loss in chronic kidney disease. (pdf
A National Public Radio interview and article
related to the MGH-MIT Grand Challenge grants featuring Drs. Lin, Ausiello and Cima appeared recently.
(Electronic and Telecommunication Research Institute, Korea) and KBRI
(Korea Brain Research Institute) have signed an MoU
on research collaboration and academic exchange. The agreement is expected to promote international cooperation between these Institutions of complementary expertise, towards developing new sensing technologies.