Rapid and efficient diagnosis of bacterial infection is critical in combating infections, esp. in the hospital setting where drug resistnace to antibiotics is on the rise. CSB investigators have developed a new device to shorten the diagnosis of bacterial infection to less than 2 hours. The “PAD” system (short for polarization diagnostics) is a combination of optical read-outs of genetic bacterial information and can ultimately performed in a physician’s office at low cost.
The MGH Center for Systems Biology (CSB) was established as one of the five
thematic interdisciplinary Centers
at MGH. It is home to over 200 researchers in 12 PI groups. The mission of the Center is to analyze at a systems level how biological molecules, proteins and cells interact in both healthy and diseased states.
Through a multidisciplinary approach that combines clinical insight with powerful technologies, CSB faculty pursue systems-level research that is at once fundamental, and yet immediately linked to the diagnosis and treatment of human disease. While these approaches are generalizable to many diseases, the Center has particular strengths in complex human conditions such as cancer, cardiovascular disease, diabetes, autoimmune disease, and renal disease. This goal is enabled by particular faculty expertise in genomics, chemical biology, physiology, bioimaging, and nanotechnology.
The Center has close links with the HMS Department of Systems Biology, clinical departments at MGH, other MGH thematic centers, MIT, and the Broad Institute.
Single-molecule decoding of combinatorially modified nucleosomes.
Science. 2016;352(6286):717-21 - PMID: 27151869
Distinct bone marrow blood vessels differentially regulate haematopoiesis.
Nature. 2016;532(7599):323-328 - PMID: 27074509
Neutrophils suppress intraluminal NK-mediated tumor cell clearance and enhance extravasation of disseminated carcinoma cells.
Cancer Discov. 2016;:ePub - PMID: 27072748
Rapid identification of health care–associated infections with an integrated fluorescence anisotropy system
2016-05-09: Massachusetts General Hospital
has been named the #1 healthcare organization for research by the Nature Index
, which tracked the number of articles published in high-impact research journals from February 2015 to January 2016. According to the index, Mass General topped the list of more than 380 healthcare organizations in publishing productivity during that time frame.
2016-04-20: Ralph Weissleder, MD, PhD
, Director of CSB, has been selected to become a member of the American Academy of Arts and Sciences
this year! The American Academy, which was established in 1780 by John Adams and other founders of the United States, is one of the world’s oldest and most prestigious honorary societies. The new class of members, comprising leaders in science, social science, humanities, art, business and public affairs, will be inducted at a ceremony Oct. 8 in Cambridge, MA. Congratulations, Ralph!