Ralph Weissleder's Lab
My laboratory has currently three major areas of interest:
1) Quantitative single cell analysis of cancers during drug treatments in vivo (systems pharmacology);
2) Use of chemical biology and bioorthogonal chemistries to perturb and analyze protein networks to identify new drug targets;
3) Use of next-gen sensing technologies ("chips") for real-time analysis of human biology.
The lab uses a variety of tools and platforms for data acquisition. In general, we aim at obtaining:
Systems, wide global measurements
Integration of multiple, different data sets into models
Dynamic, serial measurements
Ly-6Chigh Monocytes Depend on Nr4a1 to Balance both Inflammatory and Reparative Phases in the Infarcted Myocardium.
Imaging macrophages with nanoparticles.
Innate Response Activator B Cells Aggravate Atherosclerosis by Stimulating TH1 Adaptive Immunity.
Circulation. 2014;:ePub - PMID: 24488984
Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid-Phase Peptide Synthesis
Aaron Aguirre, MD, PhD has been awarded a John S. LaDue Memorial Fellowship at Harvard Medical School. Congratulations, Aaron!
Aaron Aguirre, MD, PhD has been awarded the Eugene Braunwald Fellowship in Cardiovascular Medicine and Science. Congratulations, Aaron!