Weissleder

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Ralph Weissleder's Lab

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The Lab has a unique operation. We have always focused on selecting ideas that would have the greatest positive impact for humanity (for some current projects see here). Our primary focus is to:

  • Obtain a deeper understanding of human biology in health and disease
  • Translate new biological understanding into clinically useful diagnostics
  • Identify new therapeutic approaches and drug targets
The lab uses a variety of tools and platforms (bioimaging, chemical biology, bioengineering) for data acquisition. In general, we aim at obtaining:
  • Quantitative in vivo measurements
  • Systems-wide global measurements
  • Dynamic, serial measurements
  • An fine-grained understanding of in vivo function
We strongly encourage an unusual interdisciplinary approach, fostering collaboration between scientists and clinicians from diverse backgrounds. This convergence approach has led to many exciting discoveries and innovations at the Weissleder Lab.

Recent Publications (more...)

Vinegoni C, Leon Swisher C, Fumene Feruglio P, Giedt RJ, Rousso DL, Stapleton S, Weissleder R
Real-time high dynamic range laser scanning microscopy.
Nat Commun. 2016;7:11077 - PMID: 27032979 - PMCID: PMC4821995
Ricklefs F, Mineo M, Rooj AK, Nakano I, Charest A, Weissleder R, Breakefield XO, Chiocca EA, Godlewski J, Bronisz A
Extracellular vesicles from high grade glioma exchange diverse pro-oncogenic signals that maintain intratumoral heterogeneity.
Cancer Res. 2016;76(10):2876-2881 - PMID: 27013191 - PMCID: PMC4873326
Pucci F, Garris C, Lai CP, Newton A, Pfirschke C, Engblom C, Alvarez D, Sprachman M, Evavold C, Magnuson A, von Andrian UH, Glatz K, Breakefield XO, Mempel TR, Weissleder R, Pittet MJ
SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions
Science. 2016;352(6282):242-246 - PMID: 26989197
Park KS*, Huang CH*, Lee K, Yoo YE, Castro CM, Weissleder R, Lee H
Rapid identification of health care–associated infections with an integrated fluorescence anisotropy system
Sci Adv. 2016;2(5):e1600300

Recent News (more...)

2016-05-17: NIH Director Dr. Collins has selected CSB new paper in Science Advances on a system for rapid identification of health care-associated infections to be featured on his blog - https://directorsblog.nih.gov/. (pdf)
2016-04-20: Ralph Weissleder, MD, PhD, Director of CSB, has been selected to become a member of the American Academy of Arts and Sciences this year! The American Academy, which was established in 1780 by John Adams and other founders of the United States, is one of the world’s oldest and most prestigious honorary societies. The new class of members, comprising leaders in science, social science, humanities, art, business and public affairs, will be inducted at a ceremony Oct. 8 in Cambridge, MA. Congratulations, Ralph!
2016-04-07: Hyungsoon Im, PhD and Kisoo Park, PhD won Poster of Distinction awards at the 69th Annual Meeting of the MGH Scientific Advisory Committee (SAC). Congratulations!
2016-03-22: nPLEX is one of the greatest hits among 20 years of Nature Biotechnology biomedical research! (pdf)
2015-10-20: Kevin King was recently selected as a finalist in the Northwestern Cardiovascular Young Investigator's Forum. His project won the 1st place Fellow's Basic Science.