Ralph Weissleder's Lab
The Lab has a unique operation. We have always focused on selecting ideas that would have the greatest positive impact for humanity (for some current projects see here). Our primary focus is to:
- Obtain a deeper understanding of human biology in health and disease
- Translate new biological understanding into clinically useful diagnostics
- Identify new therapeutic approaches and drug targets
- Quantitative in vivo measurements
- Systems-wide global measurements
- Dynamic, serial measurements
- An fine-grained understanding of in vivo function
Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging.
Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease.
Quantitating drug-target engagement in single cells in vitro and in vivo.
Nat Chem Biol. 2016;13(2):168-173 - PMID: 27918558
Motion characterization scheme to minimize motion artifacts in intravital microscopy.
J Biomed Opt. 2017;22(3):36005 - PMID: 28253383
2017-02-10: Ralph Weissleder, MD PhD is one of more than 100 scientists and leaders who signed the letter “Convergence: The future of health”. It was released in Science. (pdf)
2017-02-09: Miles Miller, PhD and Kevin King, MD, PhD have been selected to serve as Associate Scientific Advisors (ASAs) for Science's sister journal, Science Translational Medicine, for 2017-2018.
2016-12-14: Sean Arlauckas, PhD of the Weissleder Lab received the honor of “Top Poster” at the 2nd Annual Symposium of the Harvard Program in Therapeutic Sciences. Congratulations, Sean!
2016-12-13: Ralph Weissleder, MD, PhD has been elected as a member of the National Academy of Inventors. The NAI Fellows Selection Committee has chosen Ralph for induction as he “has demonstrated a highly prolific spirit of innovation in creating or facilitating outstanding inventions that have made a tangible impact on quality of life, economic development, and the welfare of society.” Congratulations on this great achievement and recognition as a truly prolific academic inventor!
2016-10-07: Divya Pathania, PhD was selected to receive Translational Research Award for Lymphoma-D3 project at MGH Clinical Research Day. Congratulations, Divya!