Weissleder

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Ralph Weissleder's Lab

Weissleder_research

My laboratory has currently three major areas of interest: 1) Quantitative single cell analysis of cancers during drug treatments in vivo (systems pharmacology); 2) Use of chemical biology and bioorthogonal chemistries to perturb and analyze protein networks to identify new drug targets; 3) Use of next-gen sensing technologies ("chips") for real-time analysis of human biology.

The lab uses a variety of tools and platforms for data acquisition. In general, we aim at obtaining:

  • Quantitative measurements
  • Systems, wide global measurements
  • Integration of multiple, different data sets into models
  • Dynamic, serial measurements
  • Systems perturbations

Recent Publications (more...)

Rashidian M, Keliher EJ, Bilate AM, Duarte JN, Wojtkiewicz GR, Jacobsen JT, Cragnolini J, Swee LK, Victora GD, Weissleder R, Ploegh HL
Noninvasive imaging of immune responses.
Proc Natl Acad Sci U S A. 2015;:ePub - PMID: 25902531
Chittajallu DR, Florian S, Kohler RH, Iwamoto Y, Orth JD, Weissleder R*, Danuser G*, Mitchison TJ*
In vivo cell-cycle profiling in xenograft tumors by quantitative intravital microscopy
Nat Methods. 2015;:ePub - PMID: 25867850
Im H, Castro CM, Shao H, Liong M, Song J, Pathania D, Fexon L, Min C, Avila-Wallace M, Zurkiya O, Rho J, Magaoay B, Tambouret RH, Pivovarov M, Weissleder R*, Lee H*
Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone
Proc Natl Acad Sci U S A. 2015;:ePub - PMID: 25870273
Kessinger CW, Kim JW, Henke PK, Thompson B, McCarthy JR, Hara T, Sillesen M, Margey RJ, Libby P, Weissleder R, Lin CP, Jaffer FA
Statins Improve the Resolution of Established Murine Venous Thrombosis: Reductions in Thrombus Burden and Vein Wall Scarring.
PLoS ONE. 2015;10(2):e0116621 - PMID: 25680183 - PMCID: PMC4334538

Recent News (more...)

2014-08-04: Ralph Weissleder, MD, PhD is listed among “The World’s Most Influential Scientific Minds”. In order to be included on the list researchers had to publish the highest number of articles that rank among those most frequently cited by fellow researchers. (pdf)
2014-06-04: Congratulations to Hyungsoon Im, PhD and Miles Miller, PhD who won MGH ORCD 2014 Research Fellows Poster Celebration Awards.
2014-04-24: Biocompare features work of Lee Lab and Weissleder Lab in using exosomes as a relatively noninvasive biomarker for tumor burden and treatment efficacy.
2014-04-01: Aaron Aguirre, MD, PhD has been awarded a John S. LaDue Memorial Fellowship at Harvard Medical School. Congratulations, Aaron!
2014-03-07: Aaron Aguirre, MD, PhD has been awarded the Eugene Braunwald Fellowship in Cardiovascular Medicine and Science. Congratulations, Aaron!