Weissleder

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Ralph Weissleder's Lab

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The Lab has a unique operation. We have always focused on selecting ideas that would have the greatest positive impact for humanity (for some current projects see here). Our primary focus is to:

  • Obtain a deeper understanding of human biology in health and disease
  • Translate new biological understanding into clinically useful diagnostics
  • Identify new therapeutic approaches and drug targets
The lab uses a variety of tools and platforms (bioimaging, chemical biology, bioengineering) for data acquisition. In general, we aim at obtaining:
  • Quantitative in vivo measurements
  • Systems-wide global measurements
  • Dynamic, serial measurements
  • An fine-grained understanding of in vivo function
We strongly encourage an unusual interdisciplinary approach, fostering collaboration between scientists and clinicians from diverse backgrounds. This convergence approach has led to many exciting discoveries and innovations at the Weissleder Lab.

Recent Publications (more...)

Hoyer FF, Naxerova K, Schloss MJ, Hulsmans M, Nair AV, Dutta P, Calcagno DM, Herisson F, Anzai A, Sun Y, Wojtkiewicz G, Rohde D, Frodermann V, Vandoorne K, Courties G, Iwamoto Y, Garris CS, Williams DL, Breton S, Brown D, Whalen M, Libby P, Pittet MJ, King KR, Weissleder R, Swirski FK, Nahrendorf M
Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge.
Immunity. 2019;51(5):899-914.e7 - PMID: 31732166 - PMCID: PMC6892583 - DOI: 10.1016/j.immuni.2019.10.010
Rodell CB, Ahmed MS, Garris CS, Pittet MJ, Weissleder R
Development of adamantane-conjugated TLR7/8 agonists for supramolecular delivery and cancer immunotherapy
Theranostics. 2019;:ePub
Ng TSC, Garlin MA, Weissleder R, Miller MA
Understanding the EPR effect through image-guided systems pharmacology
Theranostics. 2019;:ePub
Koch PD, Ahmed MS, Kohler RH, Li R, Weissleder R
Imaging of Tie2 with a fluorescently labeled small molecule affinity ligand.
ACS Chem Biol. 2019;:ePub - PMID: 31809013 - DOI: 10.1021/acschembio.9b00724

Recent News (more...)

2019-08-21: New PLoS Biology paper presents detailed, standardized citation data annotated for multiple impact indicators and their composite across science. Ralph Weissleder is in the top 0.01% of scientists based on their impact. Several other CSB PIs are in the top 1%. The raw data are available for download.
2019-05-20: Maaz Ahmed and Chris Rodell (Weissleder lab) presented at the annual MGH Post Doctoral Division’s Research Fellow Poster Celebration. Chris received the Tayyaba Hasan Poster of Prestige Award which recognizes outstanding contributions to the MGH research enterprise. Congratulations!
2019-01-30: Jouha Min and Jina Ko (Weissleder Lab) participated in the Mass General Research Institute Science Slam, which was co-hosted by Mass General's five thematic research centers. The event gave scientists the chance to speak about their science in front of a live audience without using slides or scientific jargon. Checkout video highlights!
2019-01-08: Weissleder Lab has earned a Blue Flame Award from Addgene. This accolade serves to congratulate researchers who have at least one plasmid that has been distributed to the research community more than 100 times.
2018-12-26: Five CSB PIs are on the list of Highly Cited Researchers of 2018. Congratulations to Brad Bernstein, Matthias Nahrendorf, Mikael Pittet, Fil Swirski, and Ralph Weissleder!