Ralph Weissleder's Lab


My laboratory has currently three major areas of interest: 1) Quantitative single cell analysis of cancers during drug treatments in vivo (systems pharmacology); 2) Use of chemical biology and bioorthogonal chemistries to perturb and analyze protein networks to identify new drug targets; 3) Use of next-gen sensing technologies ("chips") for real-time analysis of human biology.

The lab uses a variety of tools and platforms for data acquisition. In general, we aim at obtaining:

  • Quantitative measurements
  • Systems, wide global measurements
  • Integration of multiple, different data sets into models
  • Dynamic, serial measurements
  • Systems perturbations

Recent Publications (more...)

Weissleder R, Nahrendorf M
Advancing biomedical imaging
Proc Natl Acad Sci U S A. 2015;:ePub
Miller MA, Gadde S, Pfirschke C, Engblom C, Sprachman MM, Kohler RH, Yang KS, Laughney AM, Wojtkiewicz G, Kamal N, Bhonagiri S, Pittet MJ, Farokhzad OC, Weissleder R
Predicting therapeutic nano-medicine efficacy using a companion MR imaging nanoparticle.
Sci Transl Med. 2015;7:314 - PMID: 26582898
Miller MA, Zheng YR, Gadde S, Pfirschke C, Zope H, Engblom C, Kohler RH, Iwamoto Y, Yang KS, Askevold B, Kolishetti N, Pittet M, Lippard SJ, Farokhzad OC, Weissleder R
Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug.
Nat Commun. 2015;6:8692 - PMID: 26503691
Ullal AV, Weissleder R
Photocleavable DNA Barcoding Antibodies for Multiplexed Protein Analysis in Single Cells.
Methods Mol Biol. 2015;1346:47-54 - PMID: 26542714

Recent News (more...)

2015-10-20: Kevin King was recently selected as a finalist in the Northwestern Cardiovascular Young Investigator's Forum. His project won the 1st place Fellow's Basic Science.
2015-07-23: Ralph Weissleder, MD, PhD was elected as a member of the German National Academy of Sciences, the Leopoldina, in recognition of his scientific achievements.
2015-06-24: Recent CSB work has been published on BPoD – Biomedical Picture of the Day.
2015-06-16: CSB developed nano-plasmonic exosome (”nPLEX”) technology won the Most promising translational research award given by CaNCURE Nanomedicine Program during their annual Nanomedicine Day.
2015-06-05: Divya Pathania, PhD received an award at the MGH ORCD 2015 Research Fellows Poster Celebration