Weissleder

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Ralph Weissleder's Lab

Weissleder_research

My laboratory has currently three major areas of interest: 1) Quantitative single cell analysis of cancers during drug treatments in vivo (systems pharmacology); 2) Use of chemical biology and bioorthogonal chemistries to perturb and analyze protein networks to identify new drug targets; 3) Use of next-gen sensing technologies ("chips") for real-time analysis of human biology.

The lab uses a variety of tools and platforms for data acquisition. In general, we aim at obtaining:

  • Quantitative measurements
  • Systems, wide global measurements
  • Integration of multiple, different data sets into models
  • Dynamic, serial measurements
  • Systems perturbations

Recent Publications (more...)

Konishi M, Erdem SS, Weissleder R, Lichtman AH, McCarthy J, Libby P
Imaging Granzyme B Activity Assesses Immune-Mediated Myocarditis.
Circ Res. 2015;:ePub - PMID: 26199323
Glenn DR#, Lee K#, Park H, Weissleder R, Yacoby A, Lukin MD, Lee H*, Walsworth RL*, Connolly CB*
Single-cell magnetic imaging using a quantum diamond microscope.
Nat Methods. 2015;:ePub - PMID: 26098019
Tawakol A, Hara T, Truelove J, Wojtkiewicz GR, Hucker WJ, MacNabb MH, Brownell AL, Jokivarsi K, Kessinger CW, Jaff MR, Henke PK, Weissleder R, Jaffer FA
Response to Letter Regarding Article, "18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Enables the Detection of Recurrent Same-Site Deep Vein Thrombosis by Illuminating Recently Formed, Neutrophil-Rich Thrombus"
Circulation. 2015;131(24):e531-2 - PMID: 26078375
Chung HJ, Pellegrini KL, Chung J, Wanigasuriya K, Jayawardene I, Lee K, Lee H, Vaidya VS, Weissleder R
Nanoparticle Detection of Urinary Markers for Point-of-Care Diagnosis of Kidney Injury.
PLoS ONE. 2015;10(7):e0133417 - PMID: 26186708 - PMCID: PMC4506142

Recent News (more...)

2015-07-23: Ralph Weissleder, MD, PhD was elected as a member of the German National Academy of Sciences, the Leopoldina, in recognition of his scientific achievements.
2015-06-24: Recent CSB work has been published on BPoD – Biomedical Picture of the Day.
2015-06-16: CSB developed nano-plasmonic exosome (”nPLEX”) technology won the Most promising translational research award given by CaNCURE Nanomedicine Program during their annual Nanomedicine Day.
2015-06-05: Divya Pathania, PhD received an award at the MGH ORCD 2015 Research Fellows Poster Celebration