Weissleder

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Ralph Weissleder's Lab

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The Lab has a unique operation. We have always focused on selecting ideas that would have the greatest positive impact for humanity (for some current projects see here). Our primary focus is to:

  • Obtain a deeper understanding of human biology in health and disease
  • Translate new biological understanding into clinically useful diagnostics
  • Identify new therapeutic approaches and drug targets
The lab uses a variety of tools and platforms (bioimaging, chemical biology, bioengineering) for data acquisition. In general, we aim at obtaining:
  • Quantitative in vivo measurements
  • Systems-wide global measurements
  • Dynamic, serial measurements
  • An fine-grained understanding of in vivo function
We strongly encourage an unusual interdisciplinary approach, fostering collaboration between scientists and clinicians from diverse backgrounds. This convergence approach has led to many exciting discoveries and innovations at the Weissleder Lab.

Recent Publications (more...)

Engblom C*, Pfirschke C*, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ
Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils
Science. 2017;358:eaal5081 - PMID: 29191879 - DOI: 10.1126/science.aal5081
Park K, Kim H, Kim S, Lee K, Park S, Song J, Min C, Khanam F, Rashu R, Bhuiyan TR, Ryan ET, Qadri F, Weissleder R, Cheon J, Charles RC, Lee H
Nano-Magnetic System For Rapid Diagnosis Of Acute Infection.
ACS Nano. 2017;11(11):11425-11432 - PMID: 29121461 - DOI: 10.1021/acsnano.7b06074
King KR, Aguirre AD, Ye YX, Sun Y, Roh JD, Ng Jr RP, Kohler RH, Arlauckas SP, Iwamoto Y, Savol A, Sadreyev RI, Kelly M, Fitzgibbons TP, Fitzgerald KA, Mitchison T, Libby P, Nahrendorf M, Weissleder R
IRF3 and type I interferons fuel a fatal response to myocardial infarction
Nature Med. 2017;23(12):1481-1487 - PMID: 29106401 - DOI: 10.1038/nm.4428
Miller MA, Kim E, Cuccarese MF, Plotkin AL, Prytyskach M, Kohler RH, Pittet MJ, Weissleder R
Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease
Chem Commun. 2017;:ePub - PMID: 29185561 - DOI: 10.1039/c7cc07581b

Recent News (more...)

2017-12-06: Two CSB PIs - Ralph Weissleder and Bradley E. Bernstein - are included in the Clarivate Analytics 2017 Highly Cited Researchers list (formerly the Thompson Reuters list).
2017-11-07: "Food Allergy Detection Device Could Remove Danger Of Dining Out" - CBS News report on the iEat device developed at CSB
2017-10-04: Aaron Aguirre, MD, PhD has received a 2017 Physician/Scientist Development Award for “Morphology and Dynamic Functions of Pericytes in the Heart.” The project will use state-of-the-art microscopy techniques to better understand the role of pericytes—unique cells that line the outer walls of the smallest blood vessels in the heart.
2017-10-04: "Observing The Development Of Type 1 Diabetes" - CSB publication has been highlighted on Snapshot of Science at Mass General
2017-08-10: CSB has been named as one of the NCI Innovative Research in Cancer Nanotechnology (IRCNs). The IRCNs engage in directed, product-focused research that aims to translate cutting-edge science and technology into the next generation of diagnostic and therapeutic tools. These platforms serve as the core technologies for a wide array of specific applications that will ultimately benefit cancer patients.