Weissleder

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Ralph Weissleder's Lab

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The Lab has a unique operation. We have always focused on selecting ideas that would have the greatest positive impact for humanity (for some current projects see here). Our primary focus is to:

  • Obtain a deeper understanding of human biology in health and disease
  • Translate new biological understanding into clinically useful diagnostics
  • Identify new therapeutic approaches and drug targets
The lab uses a variety of tools and platforms (bioimaging, chemical biology, bioengineering) for data acquisition. In general, we aim at obtaining:
  • Quantitative in vivo measurements
  • Systems-wide global measurements
  • Dynamic, serial measurements
  • An fine-grained understanding of in vivo function
We strongly encourage an unusual interdisciplinary approach, fostering collaboration between scientists and clinicians from diverse backgrounds. This convergence approach has led to many exciting discoveries and innovations at the Weissleder Lab.

Recent Publications (more...)

Hulsmans M, Aguirre AD, Bonner M, Bapat A, Cremer S, Iwamoto Y, King KR, Swirski FK, Milan DJ, Weissleder R, Nahrendorf M
Miniaturized, Programmable Pacemaker for Long-Term Studies in the Mouse
Circ Res. 2018;:ePub - DOI: 10.1161/CIRCRESAHA.118.313429
Pittet MJ, Garris CS, Arlauckas SP, Weissleder R
Recording the wild lives of immune cells.
Sci Immunol. 2018;3(27):ePub - PMID: 30194240 - DOI: 10.1126/sciimmunol.aaq0491 - Cover
Herisson F, Frodermann V, Courties G, Rohde D, Sun Y, Vandoorne K, Wojtkiewicz GR, Santos Masson G, Vinegoni C, Kim J, Kim DE, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M
Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration
Nat Neurosci. 2018;21(9):1209-1217 - PMID: 30150661 - PMCID: PMC6148759 - DOI: 10.1038/s41593-018-0213-2
Aganj I, Harisinghani MG, Weissleder R, Fischl B
Unsupervised medical image segmentation based on the local center of mass
Sci Rep. 2018;8:13012 - PMID: 30158534 - PMCID: PMC6115387 - DOI: 10.1038/s41598-018-31333-5

Recent News (more...)

2018-08-27: "AI-powered cancer diagnoses for resource limited settings" - CSB work is featured on the Nature Bioengineering blog.
2018-06-18: Christopher T. Chan, Hsing-Ying Lin, and Jouha Min were named the winners of the 2018 MGH Research Fellow Poster Celebration. Congratulations!
2018-04-11: CSB work is featured on the MGH Blog.
2018-03-28: Jouha Min, PhD (Weissleder Lab) won Poster of Distinction award at the 70th Annual Meeting of the MGH Scientific Advisory Committee (SAC). Congratulations, Jouha!
2017-12-06: Two CSB PIs - Ralph Weissleder and Bradley E. Bernstein - are included in the Clarivate Analytics 2017 Highly Cited Researchers list (formerly the Thompson Reuters list).