Weissleder

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Ralph Weissleder's Lab

Weissleder_research

My laboratory has currently three major areas of interest: 1) Quantitative single cell analysis of cancers during drug treatments in vivo (systems pharmacology); 2) Use of chemical biology and bioorthogonal chemistries to perturb and analyze protein networks to identify new drug targets; 3) Use of next-gen sensing technologies ("chips") for real-time analysis of human biology.

The lab uses a variety of tools and platforms for data acquisition. In general, we aim at obtaining:

  • Quantitative measurements
  • Systems, wide global measurements
  • Integration of multiple, different data sets into models
  • Dynamic, serial measurements
  • Systems perturbations

Recent Publications (more...)

Glenn DR#, Lee K#, Park H, Weissleder R, Yacoby A, Lukin MD, Lee H*, Walsworth RL*, Connolly CB*
Single-cell magnetic imaging using a quantum diamond microscope.
Nat Methods. 2015;:ePub - PMID: 26098019
Tawakol A, Hara T, Truelove J, Wojtkiewicz GR, Hucker WJ, MacNabb MH, Brownell AL, Jokivarsi K, Kessinger CW, Jaff MR, Henke PK, Weissleder R, Jaffer FA
Response to Letter Regarding Article, "18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Enables the Detection of Recurrent Same-Site Deep Vein Thrombosis by Illuminating Recently Formed, Neutrophil-Rich Thrombus"
Circulation. 2015;131(24):e531-2 - PMID: 26078375
Lai CP, Kim EY, Badr CE, Weissleder R, Mempel TR, Tannous BA, Breakefield XO
Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters.
Nat Commun. 2015;6:7029 - PMID: 25967391 - PMCID: PMC4435621
Abazari A, Meimetis LG, Budin G, Bale SS, Weissleder R, Toner M
Engineered Trehalose Permeable to Mammalian Cells.
PLoS ONE. 2015;10(6):e0130323 - PMID: 26115179 - PMCID: PMC4482662

Recent News (more...)

2015-06-24: Recent CSB work has been published on BPoD – Biomedical Picture of the Day.
2015-06-16: CSB developed nano-plasmonic exosome (”nPLEX”) technology won the Most promising translational research award given by CaNCURE Nanomedicine Program during their annual Nanomedicine Day.
2015-06-05: Divya Pathania, PhD received an award at the MGH ORCD 2015 Research Fellows Poster Celebration
2014-08-04: Ralph Weissleder, MD, PhD is listed among “The World’s Most Influential Scientific Minds”. In order to be included on the list researchers had to publish the highest number of articles that rank among those most frequently cited by fellow researchers. (pdf)