Ralph Weissleder's Lab
My laboratory has currently three major areas of interest:
1) Quantitative single cell analysis of cancers during drug treatments in vivo (systems pharmacology);
2) Use of chemical biology and bioorthogonal chemistries to perturb and analyze protein networks to identify new drug targets;
3) Use of next-gen sensing technologies ("chips") for real-time analysis of human biology.
The lab uses a variety of tools and platforms for data acquisition. In general, we aim at obtaining:
Systems, wide global measurements
Integration of multiple, different data sets into models
Dynamic, serial measurements
Advancing biomedical imaging
Proc Natl Acad Sci U S A. 2015;:ePub
Predicting therapeutic nano-medicine efficacy using a companion MR imaging nanoparticle.
Sci Transl Med. 2015;7:314 - PMID: 26582898
Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug.
Nat Commun. 2015;6:8692 - PMID: 26503691
Photocleavable DNA Barcoding Antibodies for Multiplexed Protein Analysis in Single Cells.
Methods Mol Biol. 2015;1346:47-54 - PMID: 26542714
2015-10-20: Kevin King was recently selected as a finalist in the Northwestern Cardiovascular Young Investigator's Forum. His project won the 1st place Fellow's Basic Science.
2015-06-05: Divya Pathania, PhD received an award at the MGH ORCD 2015 Research Fellows Poster Celebration