Ralph Weissleder's Lab


The Lab has a unique operation. We have always focused on selecting ideas that would have the greatest positive impact for humanity (for some current projects see here). Our primary focus is to:

  • Obtain a deeper understanding of human biology in health and disease
  • Translate new biological understanding into clinically useful diagnostics
  • Identify new therapeutic approaches and drug targets
The lab uses a variety of tools and platforms (bioimaging, chemical biology, bioengineering) for data acquisition. In general, we aim at obtaining:
  • Quantitative in vivo measurements
  • Systems-wide global measurements
  • Dynamic, serial measurements
  • An fine-grained understanding of in vivo function
We strongly encourage an unusual interdisciplinary approach, fostering collaboration between scientists and clinicians from diverse backgrounds. This convergence approach has led to many exciting discoveries and innovations at the Weissleder Lab.

Recent Publications (more...)

Weissleder R, Schwaiger MC, Gambhir SS, Hricak H
Imaging approaches to optimize molecular therapies
Sci Transl Med. 2016;8(355):355ps16 - PMID: 27605550
Hong S, Pirovich D, Kilcoyne A, Huang CH, Lee H, Weissleder R
Supramolecular Metallo-Bioadhesive for Minimally Invasive Use
Adv Mater. 2016;28(39):8675-8680 - PMID: 27515068
Sager HB, Hulsmans M, Lavine KJ, Beltrami Moreira MB, Heidt T, Courties G, Sun Y, Iwamoto Y, Tricot B, Khan OF, Dahlman JE, Borodovsky A, Fitzgerald K, Anderson DG, Weissleder R, Libby P, Swirski FK, Nahrendorf M
Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.
Circ Res. 2016;119(7):853-64 - PMID: 27444755
Giedt RJ, Fumene Feruglio P, Pathania D, Yang KS, Kilcoyne A, Vinegoni C, Mitchison TJ, Weissleder R
Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response
Sci Rep. 2016;6:32985 - PMID: 27609668 - PMCID: PMC5017129

Recent News (more...)

2016-10-07: Divya Pathania, PhD was selected to receive Translational Research Award for Lymphoma-D3 project at MGH Clinical Research Day. Congratulations, Divya!
2016-08-18: Two CSB fellows - Kisoo Park, PhD and Christina Pfirschke, PhD - have been selected to receive a MGH ECOR Tosteson Postdoctoral Fellowship Award. The Tosteson Awards are given to the top-ranked applicants for the Fund for Medical Discovery Postdoctoral Awards. Congratulations, Kisoo and Christina!
2016-06-01: Seonki Hong (Poster of Prestige), Chen-Han Huang (Poster of Merit), and Ashley Fenn (Poster of Distinction) received awards at 2016 MGH ORCD Research Fellows Poster Celebration. Congratulations!
2016-05-17: NIH Director Dr. Collins has selected CSB new paper in Science Advances on a system for rapid identification of health care-associated infections to be featured on his blog - https://directorsblog.nih.gov/. (pdf)
2016-04-20: Ralph Weissleder, MD, PhD, Director of CSB, has been selected to become a member of the American Academy of Arts and Sciences this year! The American Academy, which was established in 1780 by John Adams and other founders of the United States, is one of the world’s oldest and most prestigious honorary societies. The new class of members, comprising leaders in science, social science, humanities, art, business and public affairs, will be inducted at a ceremony Oct. 8 in Cambridge, MA. Congratulations, Ralph!