Weissleder

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Ralph Weissleder's Lab

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The Lab has a unique operation. We have always focused on selecting ideas that would have the greatest positive impact for humanity (for some current projects see here). Our primary focus is to:

  • Obtain a deeper understanding of human biology in health and disease
  • Translate new biological understanding into clinically useful diagnostics
  • Identify new therapeutic approaches and drug targets
The lab uses a variety of tools and platforms (bioimaging, chemical biology, bioengineering) for data acquisition. In general, we aim at obtaining:
  • Quantitative in vivo measurements
  • Systems-wide global measurements
  • Dynamic, serial measurements
  • An fine-grained understanding of in vivo function
We strongly encourage an unusual interdisciplinary approach, fostering collaboration between scientists and clinicians from diverse backgrounds. This convergence approach has led to many exciting discoveries and innovations at the Weissleder Lab.

Recent Publications (more...)

Erel-Akbaba G, Carvalho LA, Tian T, Zinter M, Akbaba H, Obeid PJ, Chiocca EA, Weissleder R, Kantarci AG, Tannous BA
Radiation-Induced Targeted Nanoparticle- Based Gene Delivery for Brain Tumor Therapy
ACS Nano. 2019;:ePub - PMID: 30916923 - DOI: 10.1021/acsnano.8b08177
He S*, Kahles F*, Rattik S*, Nairz M, McAlpine CS, Anzai A, Selgrade D, Fenn AM, Chan CT, Mindur JE, Valet C, Poller WC, Halle L, Rotllan N, Iwamoto Y, Wojtkiewicz GR, Weissleder R, Libby P, Fernández-Hernando C, Drucker DJ, Nahrendorf M, Swirski FK
Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease
Nature. 2019;566(7742):115-119 - PMID: 30700910 - PMCID: PMC6367023 - DOI: 10.1038/s41586-018-0849-9
Bae SH, Jo A, Park JH, Lim CW, Choi Y, Oh J, Park JM, Kong T, Weissleder R, Lee H, Moon J
Bioassay for monitoring the anti-aging effect of cord blood treatment.
Theranostics. 2019;9(1):1-10 - PMID: 30662549 - PMCID: PMC6332798 - DOI: 10.7150/thno.30422
Zaborowski MP, Lee K, Na YJ, Sammarco A, Zhang X, Iwanicki M, Cheah PS, Lin HY, Zinter M, Chou CY, Fulci G, Tannous BA, Lai CP, Birrer MJ, Weissleder R, Lee H, Breakefield XO
Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles.
Cell Rep. 2019;27(1):255-268.e6 - PMID: 30943406 - DOI: 10.1016/j.celrep.2019.03.003

Recent News (more...)

2019-01-30: Jouha Min and Jina Ko (Weissleder Lab) participated in the Mass General Research Institute Science Slam, which was co-hosted by Mass General's five thematic research centers. The event gave scientists the chance to speak about their science in front of a live audience without using slides or scientific jargon. Checkout video highlights!
2019-01-08: Weissleder Lab has earned a Blue Flame Award from Addgene. This accolade serves to congratulate researchers who have at least one plasmid that has been distributed to the research community more than 100 times.
2018-12-26: Five CSB PIs are on the list of Highly Cited Researchers of 2018. Congratulations to Brad Bernstein, Matthias Nahrendorf, Mikael Pittet, Fil Swirski, and Ralph Weissleder!
2018-08-27: "AI-powered cancer diagnoses for resource limited settings" - CSB work is featured on the Nature Bioengineering blog.
2018-06-18: Christopher T. Chan, Hsing-Ying Lin, and Jouha Min were named the winners of the 2018 MGH Research Fellow Poster Celebration. Congratulations!