Ralph Weissleder's Lab
My laboratory has currently three major areas of interest:
1) Quantitative single cell analysis of cancers during drug treatments in vivo (systems pharmacology);
2) Use of chemical biology and bioorthogonal chemistries to perturb and analyze protein networks to identify new drug targets;
3) Use of next-gen sensing technologies ("chips") for real-time analysis of human biology.
The lab uses a variety of tools and platforms for data acquisition. In general, we aim at obtaining:
Systems, wide global measurements
Integration of multiple, different data sets into models
Dynamic, serial measurements
Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters.
Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma
Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells
On chip analysis of CNS lymphoma in cerebrospinal fluid.
2014-06-04: Congratulations to Hyungsoon Im, PhD and Miles Miller, PhD who won MGH ORCD 2014 Research Fellows Poster Celebration Awards.
features work of Lee Lab
and Weissleder Lab
in using exosomes as a relatively noninvasive biomarker for tumor burden and treatment efficacy.
2014-04-01: Aaron Aguirre, MD, PhD has been awarded a John S. LaDue Memorial Fellowship at Harvard Medical School. Congratulations, Aaron!
2014-03-07: Aaron Aguirre, MD, PhD has been awarded the Eugene Braunwald Fellowship in Cardiovascular Medicine and Science. Congratulations, Aaron!