Nahrendorf

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Matthias Nahrendorf's Lab

The laboratory focuses on the role of immunity in cardiovascular disease, specifically in atherosclerosis and heart failure. Of particular interest are the supply and production of leukocytes by the hematopoietic system, and the signals that regulate hematopoiesis after ischemic injuries such as myocardial infarction or stroke. We described that after myocardial infarction, the spleen releases a large population of ready-made leukocytes that travel to the ischemic heart (Science 2009). We further found that after myocardial infarction, increased sympathetic nerve activity modulates the hematopoietic stem cell niche, activating migration and proliferation of myeloid progenitor cells. This, in turn, accelerated the progression of atherosclerosis (Nature 2012), possibly explaining why secondary infarcts are so common in patients. We are interested in identifying and blocking danger signals arising from ischemic injury, including neural signals that amplify systemic inflammation. The laboratory also develops and employs imaging approaches to sample biology non-invasively, using MR, nuclear, optical and hybrid imaging.

We closely collaborate with the Swirski lab and have recently founded an international consortium dedicated to translational research in ischemic heart disease.

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Recent Publications (more...)

Dutta P, Sager HB, Stengel KR, Naxerova K, Courties G, Saez B, Silberstein L, Heidt T, Sebas M, Sun Y, Wojtkiewicz G, Feruglio PF, King K, Baker JN, van der Laan AM, Borodovsky A, Fitzgerald K, Hulsmans M, Hoyer F, Iwamoto Y, Vinegoni C, Brown D, Di Carli M, Libby P, Hiebert SW, Scadden DT, Swirski FK, Weissleder R, Nahrendorf M
Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells
Cell Stem Cell. 2015;16 (5):477-487 - PMID: 25957903 - PMCID: PMC4426344
Nahrendorf M, Frantz S, Swirski FK, Mulder WJ, Randolph G, Ertl G, Ntziachristos V, Piek JJ, Stroes ES, Schwaiger M, Mann DL, Fayad ZA
Imaging Systemic Inflammatory Networks in Ischemic Heart Disease.
J Am Coll Cardiol. 2015;65(15):1583-1591 - PMID: 25881940 - PMCID: PMC4401833
Dai N, Zhao L, Wrighting D, Krämer D, Majithia A, Wang Y, Cracan V, Borges-Rivera D, Mootha VK, Nahrendorf M, Thorburn DR, Minichiello L, Altshuler D, Avruch J
IGF2BP2/IMP2-Deficient Mice Resist Obesity through Enhanced Translation of Ucp1 mRNA and Other mRNAs Encoding Mitochondrial Proteins.
Cell Metab. 2015;21(4):609-21 - PMID: 25863250
Davis RW, Eggleston H, Johnson F, Nahrendorf M, Bock PE, Peterson T, Panizzi P
In Vivo Tracking of Streptococcal Infections of Subcutaneous Origin in a Murine Model.
Mol Imaging Biol. 2015;:ePub - PMID: 25921659

Recent News (more...)

2015-05-19: Matthias Nahrendorf was appointed as consulting editor for Circulation Research.
2014-08-08: CSB work on bone marrow stem cells featured on TV - Channel 4 TV Boston (CBS). (mp4)
2014-07-11: Media response to recent publication on chronic stress.
2014-04-03: Matthias Nahrendorf, MD, PhD received the MGH Research Scholar award.