Nahrendorf

Home

About

Matthias Nahrendorf's Lab

The laboratory focuses on the role of immunity in cardiovascular disease, specifically in atherosclerosis and heart failure. Of particular interest are the supply and production of leukocytes by the hematopoietic system, and the signals that regulate hematopoiesis after ischemic injuries such as myocardial infarction or stroke. We described that after myocardial infarction, the spleen releases a large population of ready-made leukocytes that travel to the ischemic heart (Science 2009). We further found that after myocardial infarction, increased sympathetic nerve activity modulates the hematopoietic stem cell niche, activating migration and proliferation of myeloid progenitor cells. This, in turn, accelerated the progression of atherosclerosis (Nature 2012), possibly explaining why secondary infarcts are so common in patients. We are interested in identifying and blocking danger signals arising from ischemic injury, including neural signals that amplify systemic inflammation. The laboratory also develops and employs imaging approaches to sample biology non-invasively, using MR, nuclear, optical and hybrid imaging.

We closely collaborate with the Swirski lab.

Recent Publications (more...)

Binderup T, Duivenvoorden R, Fay F, van Leent MMT, Malkus J, Baxter S, Ishino S, Zhao Y, Sanchez-Gaytan B, Teunissen AJP, Frederico YCA, Tang J, Carlucci G, Lyashchenko S, Calcagno C, Karakatsanis N, Soultanidis G, Senders ML, Robson PM, Mani V, Ramachandran S, Lobatto ME, Hutten BA, Granada JF, Reiner T, Swirski FK, Nahrendorf M, Kjaer A, Fisher EA, Fayad ZA, Pérez-Medina C, Mulder WJM
Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species.
Sci Transl Med. 2019;11(506):ePub - PMID: 31434756 - DOI: 10.1126/scitranslmed.aaw7736
Tawakol A, Osborne MT, Wang Y, Hammed B, Tung B, Patrich T, Oberfeld B, Ishai A, Shin LM, Nahrendorf M, Warner ET, Wasfy J, Fayad ZA, Koenen K, Ridker PM, Pitman RK, Armstrong KA
Stress-Associated Neurobiological Pathway Linking Socioeconomic Disparities to Cardiovascular Disease.
J Am Coll Cardiol. 2019;73(25):3243-3255 - PMID: 31248544 - DOI: 10.1016/j.jacc.2019.04.042
Hulsmans M, Nahrendorf M
Smad3 Cranks Up the Appetite of Infarct Macrophages.
Circ Res. 2019;125(1):71-73 - PMID: 31219739 - PMCID: PMC6588180 - DOI: 10.1161/CIRCRESAHA.119.315306
Hoyer FF, Nahrendorf M
Interferon-ɣ regulates cardiac myeloid cells in myocardial infarction.
Cardiovasc Res. 2019;:ePub - PMID: 31161218 - DOI: 10.1093/cvr/cvz143

Recent News (more...)

2019-02-20: We are recruiting! Click here for details.
2018-12-26: Five CSB PIs are on the list of Highly Cited Researchers of 2018. Congratulations to Brad Bernstein, Matthias Nahrendorf, Mikael Pittet, Fil Swirski, and Ralph Weissleder!
2018-08-27: Boston Globe writes about our recent publication - MGH says it's discovered tiny channels connecting skull and brain
2018-07-17: Matthias Nahrendorf joins the Advisory Board for Nature Reviews Cardiology.