Matthias Nahrendorf's Lab
My laboratory focuses on the biology of cardiovascular diseases especially myocardial infarction and healing. We do this at the cell and tissue level to gain a systems wide understanding of who the cellular players are and how they interact. While we use different experimental approaches, in vivo imaging techniques feature prominently in our research. We also use genetic and proteomic techniques to drill down on effector molecules in key cells. Our end-goal is develop more effective therapies and diagnostics for clinical use.
Some of the outstanding questions in the myocardial biology that are of current interest to us include:
- What are the molecular and cellular pathways that govern infarct healing?
- Why do some patients after MI develop heart failure while others do not?
- Can we identify patients with increased risk, for instance by imaging?
- Can we improve infarct healing, and does this reduce left ventricular remodeling?
- How does standard therapy (ACE inhibition, beta blockade, ASS, statins) influence the immune response after MI?