Nahrendorf

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Matthias Nahrendorf's Lab

The laboratory focuses on the role of immunity in cardiovascular disease, specifically in atherosclerosis and heart failure. Of particular interest are the supply and production of leukocytes by the hematopoietic system, and the signals that regulate hematopoiesis after ischemic injuries such as myocardial infarction or stroke. We described that after myocardial infarction, the spleen releases a large population of ready-made leukocytes that travel to the ischemic heart (Science 2009). We further found that after myocardial infarction, increased sympathetic nerve activity modulates the hematopoietic stem cell niche, activating migration and proliferation of myeloid progenitor cells. This, in turn, accelerated the progression of atherosclerosis (Nature 2012), possibly explaining why secondary infarcts are so common in patients. We are interested in identifying and blocking danger signals arising from ischemic injury, including neural signals that amplify systemic inflammation. The laboratory also develops and employs imaging approaches to sample biology non-invasively, using MR, nuclear, optical and hybrid imaging.

We closely collaborate with the Swirski lab.

Recent Publications (more...)

Swirski FK, Nahrendorf M
Bone Marrow Takes Center Stage in Cardiovascular Disease.
Circ Res. 2016;119(6):701-3 - PMID: 27587406 - PMCID: PMC5012290
Sager HB, Hulsmans M, Lavine KJ, Beltrami Moreira MB, Heidt T, Courties G, Sun Y, Iwamoto Y, Tricot B, Khan OF, Dahlman JE, Borodovsky A, Fitzgerald K, Anderson DG, Weissleder R, Libby P, Swirski FK, Nahrendorf M
Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.
Circ Res. 2016;119(7):853-64 - PMID: 27444755
Theurl I, Hilgendorf I, Nairz M, Tymoszuk P, Haschka D, Asshoff M, He S, Gerhardt LM, Holderried TA, Seifert M, Sopper S, Fenn AM, Anzai A, Rattik S, McAlpine C, Theurl M, Wieghofer P, Iwamoto Y, Weber GF, Harder NK, Chousterman BG, Arvedson TL, McKee M, Wang F, Lutz OM, Rezoagli E, Babitt JL, Berra L, Prinz M, Nahrendorf M, Weiss G, Weissleder R, Lin HY, Swirski FK
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver
Nature Med. 2016;22(8):945-951 - PMID: 27428900 - PMCID: PMC4957133
Dutta P, Hoyer FF, Sun Y, Iwamoto Y, Tricot B, Weissleder R, Magnani JL, Swirski FK, Nahrendorf M
E-Selectin Inhibition Mitigates Splenic HSC Activation and Myelopoiesis in Hypercholesterolemic Mice With Myocardial Infarction.
Arterioscler Thromb Vasc Biol. 2016;36(9):1802-8 - PMID: 27470513 - PMCID: PMC5001901

Recent News (more...)

2016-09-16: Circulation Research spotlights a profile of Matthias Nahrendorf, MD PhD and his research. (pdf)
2016-08-15: Matthias Nahrendorf, MD, PhD was appointed International Associate Editor for the European Heart Journal.
2016-08-01: CSB investigators - Mikael Pittet, PhD, Matthias Nahrendorf, MD, PhD, and John Chen, MD, PhD - have been named Distinguished Investigators of the Academy of Radiology Research. Congratulations!
2016-07-14: CSB work is highlighted in Nature Reviews Cardiology. (pdf)
2015-09-24: Dong-Eog Kim (Dongguk University, Seoul) and Matthias Nahrendorf received the “Global Research Lab” award from the Korean government, an initiative that integrates US and Korean scientists.