Im Lab

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Phone: 617-643-5679

Photonics, plasmonics and novel materials

Our lab develops novel devices and applications using state-of the art nanoplasmonic and photonic sensors. We also develop new materials to expand the utility of these sensors. Our vision is to bridge the fields of engineering and medicine for next-generation diagnostic technologies. Based on physics and basic in nature, our ultimate goal is clinical translation.

Recent Publications

  • Van Deun J, Jo A, Li H, Lin HY, Weissleder R, Im H, Lee H Integrated Dual-Mode Chromatography to Enrich Extracellular Vesicles from Plasma. Adv Biosyst. 2020;:e1900310 - PMID: 32351054 - DOI: 10.1002/adbi.201900310

  • Raisbeck JC, Allen M, Weissleder R, Im H, Lee H Evolution Strategies Converges to Finite Differences. arXiv. 2020;:ePub

  • Pathania D, Landeros C, Rohrer L, D’Agostino V, Hong S, Degani I, Avila-Wallace M, Pivovarov M, Randall T, Weissleder R, Lee H, Im H, Castro CM Point-of-care cervical cancer screening using deep learning-based microholography. Theranostics. 2019;9(26):8438-8447 - PMID: 31879529 - PMCID: PMC6924258 - DOI: 10.7150/thno.37187

  • Park SG, Xiao X, Min J, Mun CW, Jung HS, Giannini V, Weissleder R, Maier SA, Im H, Kim DH Self‐Assembly of Nanoparticle‐Spiked Pillar Arrays for Plasmonic Biosensing. Adv Funct Mater. 2019;29(43):1904257 - DOI: 10.1002/adfm.201904257

  • Kim SJ*, Wang C*, Zhao B, Im H, Min J, Choi HJ, Tadros J, Choi NR, Castro CM, Weissleder R, Lee H, Lee K Deep transfer learning-based hologram classification for molecular diagnostics. Sci Rep. 2018;8(1):17003 - PMID: 30451953 - PMCID: PMC6242900 - DOI: 10.1038/s41598-018-35274-x

  • More publications ...

Research projects

Nanoplasmonic sensing


  • Multiplexed exosome analysis
  • Single molecular detection
Microholography


  • Advanced photonics diagnostics
  • Integrated portable imaging system
Nanospectroscopy


  • Chip-based nano-spectroscopy sensing
  • Integrated with deep learning-based data analysis
Nanophotonics


  • Next-generation optical sensing system
  • High-throughput, low-cost chip fabrication
Nano-plasmonic sensors

In the past, we have developed nanoplasmonic sensing systems (nPLEX/NPS) for exosome analysis in cancer. Ongoing projects are in the fields of highly multiplexed exosome analysis as well as for single molecule analysis.

The nPLEX sensor was highlighted as one of the greatest hits among 20 years of Nature Biotechnology biomedical research.
  • Yang KS*, Im H*, Hong S*, Pergolini I, Del Castillo AF, Wang R, Clardy S, Huang CH, Pille C, Ferrone S, Yang R, Castro CM, Lee H, Del Castillo CF, Weissleder R. Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy. Sci Transl Med. 2017;9(391):eaal3226 – PMID: 28539469.
  • Im H*, Shao H*, Park YI, Peterson VM, Castro CM, Weissleder R*, Lee H*. Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor. Nature Biotechnol. 2014;32(5):490-5 – PMID: 24752081

News

2020-03-30: Hyungsoon Im has received the Young Investigator Award from the 2020 Human Frontier Science Program. The program supports international collaboration in cutting-edge, interdisciplinary research focused on the life science.
2019-04-22: Daem Celestin, an undergraduate student from Northeastern University, won the Research Award in the Physical and Life Sciences at the RISE: 2019 event. She has been working on the nPLEX technology for high-throughput EV protein analysis under the guidance of Drs. Hyungsoon Im and Cesar Castro.
2018-10-30: Hyungsoon Im received Award of Excellence (1st place) at the 7th Annual MGH Radiology Research Celebration and Poster Session
2018-08-27: "AI-powered cancer diagnoses for resource limited settings" - CSB work is featured on the Nature Bioengineering blog.
2018-04-11: CSB work is featured on the MGH Blog.