The Biomedical Engineering program at CSB brings together four different labs (Lee, Im, Castro and Weissleder) interested in medical applications of next generations technologies. Members of the Program meet weekly to discuss the latest research, plan future experiments, review the literature and interact with other groups. Some of the innovative technologies developed to date are shown below.
Microfluidic chip for exosome analysis
This chip integrates pneumatic valves, membrance filters, and a microcoil. Exosomes are magnetically labeled on chip, and detected by NMR.
Microfiltration device for exosome collection
The device directly filters whole bloods and collects extracellular vesicles. The filter sets are clamped by a pair of ring magnets.
Nanoplasmonic exosome (nPLEX) sensor
The sensor contains nanohole arrays that sustain surface plasmon resonance. It detect exosomes in a label-free manner.
Microfluidic cell sorter
Based on size separation, this device enriches CTCs from unprocessed whole bloods, and allows for on-chip culture and molecular profiling.
Oh J, Carlson JCT, Landeros C, Lee H, Ferguson S, Faquin WC, Clark JR, Pittet MJ, Pai SI, Weissleder R Rapid serial immunoprofiling of the tumor immune microenvironment by fine needle sampling. Clin Cancer Res. 2021;27(17):4781-4793 - PMID: 34233961 - PMCID: PMC8416923 - DOI: 10.1158/1078-0432.CCR-21-1252
Park J, Park JS, Huang CH, Jo A, Cook K, Wang R, Lin HY, Van Deun J, Li H, Min J, Wang L, Yoon G, Carter BS, Balaj L, Choi GS, Castro CM, Weissleder R, Lee H An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma. Nat Biomed Eng. 2021;5(7):678-689 - PMID: 34183802 - PMCID: PMC8437135 - DOI: 10.1038/s41551-021-00752-7
Choi JH, Chin LK, Woo BM, Song Y, Seol MJ, Hong Y, Liu AQ, Jang S, Ploegh H, Im H, Lee D Hydrogel-Based Stamping Technology for Solution-Free Blood Cell Staining. ACS Appl Mater Interfaces. 2021;13(19):22124-22130 - PMID: 33870697 - DOI: 10.1021/acsami.0c22521
Kim H, Choia SK, Ahn J, Yu H, Kyoungha Min K, Hong C, Shin IS, Lee S, Lee H, Im H, Ko JG, Kim E Kaleidoscopic fluorescent arrays for machine-learning-based point-of-care chemical sensing. Sensors and Actuators B: Chemical. 2020;329:129248 - DOI: 10.1016/j.snb.2020.129248
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Ismail Degani (Lee Lab) was awarded with a prestigious MathWorks Fellowship for his work of combining diagnostic systems with machine learning. Congratulations Ish!
Hyungsoon Im has received the Young Investigator Award from the 2020 Human Frontier Science Program. The program supports international collaboration in cutting-edge, interdisciplinary research focused on the life science.
The Chedza Study has started with the first enrollments. This project is evaluating the accuracy of a near-to-care device for the diagnosis of breast cancer and, separately, non-Hodgkin lymphoma. The team opted to name the project Chedza (light in Sekalanga) as the new instrument developed by CSB Biomedical Engineering Program uses the bending of light around cancer cells and a smartphone camera to permit diagnosis in a few minutes.
Hyungsoon Im received Award of Excellence (1st place) at the 7th Annual MGH Radiology Research Celebration and Poster Session