Biomedical Engineering
The Biomedical Engineering program at CSB brings together four different labs (Lee, Im, Castro and Weissleder) interested in medical applications of next generations technologies. Members of the Program meet weekly to discuss the latest research, plan future experiments, review the literature and interact with other groups. Some of the innovative technologies developed to date are shown below.
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Microfluidic chip for exosome analysis
This chip integrates pneumatic valves, membrance filters, and a microcoil. Exosomes are magnetically labeled on chip, and detected by NMR.
PMID: 23142818
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Microfiltration device for exosome collection
The device directly filters whole bloods and collects extracellular vesicles. The filter sets are clamped by a pair of ring magnets.
PMID: 24295203
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Nanoplasmonic exosome (nPLEX) sensor
The sensor contains nanohole arrays that sustain surface plasmon resonance. It detect exosomes in a label-free manner.
PMID: 24752081
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Microfluidic cell sorter
Based on size separation, this device enriches CTCs from unprocessed whole bloods, and allows for on-chip culture and molecular profiling.
PMID: 23184773
Recent Publications
Lee CY, Kim H, Degani I, Lee H, Sandoval A, Nam Y, Pascavis M, Park HG, Randall T, Ly A, Castro CM, Lee H Empowering the on-site detection of nucleic acids by integrating CRISPR and digital signal processing. Nat Commun. 2024;15(1):6271 - PMID: 39054353 - DOI: 10.1038/s41467-024-50588-3
You DG, Jung JM, Kim CH, An JY, Bui VD, Lee J, Um W, Jo DG, Cho YW, Lee DS, Balaj L, Lee H, Park JH Stem Cell-Derived Extracellular Vesicle-Bearing Injectable Hydrogel for Collagen Generation in Dermis. ACS Appl Mater Interfaces. 2024;16(29):37698-37706 - PMID: 38980897 - DOI: 10.1021/acsami.4c07434
Arai MS, Kim H, Pascavis M, Cha B, Brambilla G, Cho YK, Park J, Vilela RRC, de Camargo ASS, Castro CM, Lee H Upconverting Nanoparticle-based Enhanced Luminescence Lateral-Flow Assay for Urinary Biomarker Monitoring. ACS Appl Mater Interfaces. 2024;16(29):38243-38251 - PMID: 38980927 - DOI: 10.1021/acsami.4c06117
Ssedyabane F, Obuku EA, Namisango E, Ngonzi J, Castro CM, Lee H, Randall TC, Ocan M, Apunyo R, Annet Kinengyere A, Kajabwangu R, Tahirah Kisawe A, Nambi Najjuma J, Tusubira D, Niyonzima N The diagnostic accuracy of serum and plasma microRNAs in detection of cervical intraepithelial neoplasia and cervical cancer: A systematic review and meta-analysis. Gynecol Oncol Rep. 2024;54:101424 - PMID: 38939506 - PMCID: PMC11208915 - DOI: 10.1016/j.gore.2024.101424
- More publications ...
News
The Biomedical Engineering Team had their Annual Summer BBQ.
Young Kwan Cho (the Lee Lab) was featured in a hospital-wide poster during MGH Graduate Student Appreciation Week. We appreciate all graduate students for their dedication to research. Congratulations Young Kwan!
Ala Jo (Lee Lab) was selected as Sejong Research Fellow (Korea), a highly prestigious and competitive position for an independent researcher. Congratulations Ala!!
Dr. Jin-Ho Park in the Lee lab has been awarded with Alumni Fellowship from Soongsil University (Korea) for his excellence in research. Congratulations Jin-Ho!
Ismail Degani (Lee Lab) was awarded with a prestigious MathWorks Fellowship for his work of combining diagnostic systems with machine learning. Congratulations Ish!