The Biomedical Engineering program at CSB brings together four different labs (Lee, Im, Castro and Weissleder) interested in medical applications of next generations technologies. Members of the Program meet weekly to discuss the latest research, plan future experiments, review the literature and interact with other groups. Some of the innovative technologies developed to date are shown below.
Microfluidic chip for exosome analysis
This chip integrates pneumatic valves, membrance filters, and a microcoil. Exosomes are magnetically labeled on chip, and detected by NMR.
Microfiltration device for exosome collection
The device directly filters whole bloods and collects extracellular vesicles. The filter sets are clamped by a pair of ring magnets.
Nanoplasmonic exosome (nPLEX) sensor
The sensor contains nanohole arrays that sustain surface plasmon resonance. It detect exosomes in a label-free manner.
Microfluidic cell sorter
Based on size separation, this device enriches CTCs from unprocessed whole bloods, and allows for on-chip culture and molecular profiling.
Cho YK, Kim H, Bénard A, Woo HK, Czubayko F, David P, Hansen FJ, Lee JI, Park JH, Schneck E, Weber GF, Shin IK, Lee H Electrochemiluminescence in paired signal electrode (ECLipse) enables modular and scalable biosensing. Sci Adv. 2022;8:eabq4022 - PMID: 36129990 - PMCID: PMC9491722 - DOI: 10.1126/sciadv.abq4022
Chin LK, Li H, Choi JH, Iwamoto Y, Oh J, Min J, Beak SK, Yoo D, Castro CM, Lee D, Im H Hydrogel Stamping for Rapid, Multiplexed, Point-of-Care Immunostaining of Cells and Tissues. ACS Appl Mater Interfaces. 2022;14(24):27613-27622 - PMID: 35671240 - DOI: 10.1021/acsami.2c05071
Kim H, Sa JK, Kim J, Cho HJ, Oh HJ, Choi DH, Kang SH, Jeong DE, Nam DH, Lee H, Lee HW, Chung S Recapitulated Crosstalk between Cerebral Metastatic Lung Cancer Cells and Brain Perivascular Tumor Microenvironment in a Microfluidic Co-Culture Chip. Adv Sci (Weinh). 2022;9(22):e2201785 - PMID: 35657027 - PMCID: PMC9353479 - DOI: 10.1002/advs.202201785
Lee SE, Jeong SE, Hong JS, Im H, Hwang SY, Oh JK, Kim SE Gold-Nanoparticle-Coated Magnetic Beads for ALP-Enzyme-Based Electrochemical Immunosensing in Human Plasma. Materials (Basel). 2022;15:6875 - DOI: 10.3390/ma15196875
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Young Kwan Cho (the Lee Lab) was featured in a hospital-wide poster during MGH Graduate Student Appreciation Week. We appreciate all graduate students for their dedication to research. Congratulations Young Kwan!
Ala Jo (Lee Lab) was selected as Sejong Research Fellow (Korea), a highly prestigious and competitive position for an independent researcher. Congratulations Ala!!
Dr. Jin-Ho Park in the Lee lab has been awarded with Alumni Fellowship from Soongsil University (Korea) for his excellence in research. Congratulations Jin-Ho!
Ismail Degani (Lee Lab) was awarded with a prestigious MathWorks Fellowship for his work of combining diagnostic systems with machine learning. Congratulations Ish!