The Biomedical Engineering program at CSB brings together four different labs (Lee, Im, Castro and Weissleder) interested in medical applications of next generations technologies. Members of the Program meet weekly to discuss the latest research, plan future experiments, review the literature and interact with other groups. Some of the innovative technologies developed to date are shown below.
Microfluidic chip for exosome analysis
This chip integrates pneumatic valves, membrance filters, and a microcoil. Exosomes are magnetically labeled on chip, and detected by NMR.
Microfiltration device for exosome collection
The device directly filters whole bloods and collects extracellular vesicles. The filter sets are clamped by a pair of ring magnets.
Nanoplasmonic exosome (nPLEX) sensor
The sensor contains nanohole arrays that sustain surface plasmon resonance. It detect exosomes in a label-free manner.
Microfluidic cell sorter
Based on size separation, this device enriches CTCs from unprocessed whole bloods, and allows for on-chip culture and molecular profiling.
Kim K, Lee B, Park JH, Park JH, Lee KJ, Kwak TJ, Son T, Shin YB, Im H, Kim MG Rapid PCR kit: lateral flow paper strip with Joule heater for SARS-CoV-2 detection. Mater Horiz. 2023;:ePub - PMID: 36843375 - DOI: 10.1039/d2mh01267g
Ansah IB, Leming M, Lee SH, Yang JY, Mun C, Noh K, An T, Lee S, Kim DH, Kim M, Im H, Park SG Label-free detection and discrimination of respiratory pathogens based on electrochemical synthesis of biomaterials-mediated plasmonic composites and machine learning analysis. Biosens Bioelectron. 2023;227:115178 - PMID: 36867960 - DOI: 10.1016/j.bios.2023.115178
Roh YH, Lee CY, Lee S, Kim H, Ly A, Castro CM, Cheon J, Lee JH, Lee H CRISPR-Enhanced Hydrogel Microparticles for Multiplexed Detection of Nucleic Acids. Adv Sci (Weinh). 2023;:e2206872 - PMID: 36725305 - DOI: 10.1002/advs.202206872
Leming M, Das S, Im H Adversarial confound regression and uncertainty measurements to classify heterogeneous clinical MRI in Mass General Brigham. PLoS ONE. 2023;18(3):e0277572 - PMID: 36862751 - PMCID: PMC9980829 - DOI: 10.1371/journal.pone.0277572
- More publications ...
Young Kwan Cho (the Lee Lab) was featured in a hospital-wide poster during MGH Graduate Student Appreciation Week. We appreciate all graduate students for their dedication to research. Congratulations Young Kwan!
Ala Jo (Lee Lab) was selected as Sejong Research Fellow (Korea), a highly prestigious and competitive position for an independent researcher. Congratulations Ala!!
Dr. Jin-Ho Park in the Lee lab has been awarded with Alumni Fellowship from Soongsil University (Korea) for his excellence in research. Congratulations Jin-Ho!
Ismail Degani (Lee Lab) was awarded with a prestigious MathWorks Fellowship for his work of combining diagnostic systems with machine learning. Congratulations Ish!
The journal iScience interviewed research groups worldwide for their COVID-19 responses. The Lee Lab is featured in this story