Hakho Lee

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Hakho Lee’s Lab

Sensitive, fast and cost-effective diagnostic systems can have far-reaching implications in medicine and life sciences. My laboratory specializes in developing such sensors by bringing together ideas and techniques embodied in physics, engineering, and computation. Our research is guided by core principles – thorough understanding of underlying sensing mechanisms and providing robust engineering solutions. We further apply developed sensors to quantitatively analyze living systems. These efforts are key requisite for finding new biomarkers for early intervention as well as for developing targeted therapies.

Recent Publications (more...)

Huber S, Min C, Staat C, Oh J, Castro CM, Haase A, Weissleder R, Gleich B, Lee H
Multichannel digital heteronuclear magnetic resonance biosensor.
Biosens Bioelectron. 2018;126:240-248 - PMID: 30445298 - DOI: 10.1016/j.bios.2018.10.052
Min J, Im H, Allen M, McFarland PJ, Degani I, Yu H, Normandin E, Pathania D, Patel J, Castro CM, Weissleder R, Lee H
Computational Optics Enables Breast Cancer Profiling in Point-Of-Care Settings.
ACS Nano. 2018;12(9):9081-9090 - PMID: 30113824 - DOI: 10.1021/acsnano.8b03029
Im H, Pathania D, McFarland PJ, Sohani AR, Degani I, Allen M, Coble M, Kilcoyne A, Hong S, Rohrer L, Abramson JS, Dryden-Peterson S, Fexon L, Pivovarov M, Chabner B, Lee H, Castro CM, Weissleder R
Design and clinical validation of a point-of-care device for the diagnosis of lymphoma via contrast- enhanced microholography and machine learning
Nature Biomedical Engineering. 2018;:ePub - DOI: 10.1038/s41551-018-0265-3
Kim SJ*, Wang C*, Zhao B, Im H, Min J, Choi HJ, Tadros J, Choi NR, Castro CM, Weissleder R, Lee H, Lee K
Deep transfer learning-based hologram classification for molecular diagnostics.
Sci Rep. 2018;8(1):17003 - PMID: 30451953 - PMCID: PMC6242900 - DOI: 10.1038/s41598-018-35274-x

Recent News (more...)

2018-08-27: "AI-powered cancer diagnoses for resource limited settings" - CSB work is featured on the Nature Bioengineering blog.
2018-08-23: Hsing-Ying Lin (Lee Lab) has been selected to receive a MGH ECOR Fund for Medical Discovery (FMD) Postdoctoral Fellowship Award. Congratulations!
2018-06-18: Christopher T. Chan, Hsing-Ying Lin, and Jouha Min were named the winners of the 2018 MGH Research Fellow Poster Celebration. Congratulations!
2018-04-11: CSB work is featured on the MGH Blog.
2017-11-07: "Food Allergy Detection Device Could Remove Danger Of Dining Out" - CBS News report on the iEat device developed at CSB