Hakho Lee

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Hakho Lee’s Lab

Sensitive, fast and cost-effective diagnostic systems can have far-reaching implications in medicine and life sciences. My laboratory specializes in developing such sensors by bringing together ideas and techniques embodied in physics, engineering, and computation. Our research is guided by core principles – thorough understanding of underlying sensing mechanisms and providing robust engineering solutions. We further apply developed sensors to quantitatively analyze living systems. These efforts are key requisite for finding new biomarkers for early intervention as well as for developing targeted therapies.

Recent Publications (more...)

Shao H, Im H, Castro CM, Breakefield X, Weissleder R, Lee H
New Technologies for Analysis of Extracellular Vesicles.
Chem Rev. 2018;:ePub - PMID: 29384376 - DOI: 10.1021/acs.chemrev.7b00534
Lee K, Fraser K, Ghaddar B, Yang K, Kim E, Balaj L, Chiocca A, Breakefield XO, Lee H, Weissleder R
Multiplexed Profiling of Single Extracellular Vesicles.
ACS Nano. 2017;12(1):494-503 - PMID: 29286635 - DOI: 10.1021/acsnano.7b07060
Park K, Kim H, Kim S, Lee K, Park S, Song J, Min C, Khanam F, Rashu R, Bhuiyan TR, Ryan ET, Qadri F, Weissleder R, Cheon J, Charles RC, Lee H
Nano-Magnetic System For Rapid Diagnosis Of Acute Infection.
ACS Nano. 2017;11(11):11425-11432 - PMID: 29121461 - DOI: 10.1021/acsnano.7b06074
Park J*, Im H*, Hong S, Castro CM, Weissleder R, Hakho Lee H
Analyses of Intravesicular Exosomal Proteins Using a Nano-Plasmonic System
ACS Photonics. 2017;:ePub - DOI: 10.1021/acsphotonics.7b00992

Recent News (more...)

2017-11-07: "Food Allergy Detection Device Could Remove Danger Of Dining Out" - CBS News report on the iEat device developed at CSB
2017-09-18: The work of Lee Lab on detecting and profiling circulating ovarian cancer cells is highlighted on the Congressionally Directed Medical Research Programs (CDMRP) site.
2017-04-06: Hakho Lee, PhD has been selected as a 2017 MGH Research Scholar. Congratulations, Hakho!
2016-06-01: Seonki Hong (Poster of Prestige), Chen-Han Huang (Poster of Merit), and Ashley Fenn (Poster of Distinction) received awards at 2016 MGH ORCD Research Fellows Poster Celebration. Congratulations!