Hakho Lee

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Hakho Lee’s Lab

Sensitive, fast and cost-effective diagnostic systems can have far-reaching implications in medicine and life sciences. My laboratory specializes in developing such sensors by bringing together ideas and techniques embodied in physics, engineering, and computation. Our research is guided by core principles – thorough understanding of underlying sensing mechanisms and providing robust engineering solutions. We further apply developed sensors to quantitatively analyze living systems. These efforts are key requisite for finding new biomarkers for early intervention as well as for developing targeted therapies.

Recent Publications (more...)

Loyer X, Zlatanova I, Devue C, Yin M, Howangyin KY, Klaihmon P, Guerin CL, Kheloufi M, Vilar J, Zannis K, Fleischmann BK, Hwang DW, Park J, Lee H, Menasche P, Silvestre JS, Boulanger CM
Intra-Cardiac Release of Extracellular Vesicles Shapes Inflammation Following Myocardial Infarction.
Circ Res. 2018;:ePub - PMID: 29592957 - DOI: 10.1161/CIRCRESAHA.117.311326
Min J, Nothing M, Coble B, Zheng H, Park J, Im H, Weber GF, Castro CM, Swirski FK, Weissleder R, Lee H
Integrated Biosensor for Rapid and Point-Of-Care Sepsis Diagnosis.
ACS Nano. 2018;12(4):3378-3384 - PMID: 29533646 - DOI: 10.1021/acsnano.7b08965
Shao H, Im H, Castro CM, Breakefield X, Weissleder R, Lee H
New Technologies for Analysis of Extracellular Vesicles.
Chem Rev. 2018;118(4):1917-1950 - PMID: 29384376 - DOI: 10.1021/acs.chemrev.7b00534
Ling R, Tahir W, Lin HY, Lee H, Tian L
High-throughput intensity diffraction tomography with a computational microscope.
Biomed Opt Express. 2018;9(5):2130-2141 - PMID: 29760975 - PMCID: PMC5946776 - DOI: 10.1364/BOE.9.002130

Recent News (more...)

2018-06-18: Christopher T. Chan, Hsing-Ying Lin, and Jouha Min were named the winners of the 2018 MGH Research Fellow Poster Celebration. Congratulations!
2018-04-11: CSB work is featured on the MGH Blog.
2017-11-07: "Food Allergy Detection Device Could Remove Danger Of Dining Out" - CBS News report on the iEat device developed at CSB
2017-09-18: The work of Lee Lab on detecting and profiling circulating ovarian cancer cells is highlighted on the Congressionally Directed Medical Research Programs (CDMRP) site.