Hakho Lee

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Hakho Lee’s Lab

Our vision is to create sophisticated platform technologies that detect disease much earlier than currently possible. We integrate core concepts in nanomaterials, biophysics, electronics, and computation with a thorough understanding of underlying sensing mechanisms, to arrive at robust engineering solutions. In all, we have advanced various new sensors optimized for specific medical or research needs, many of which have been tested in clinical trials and commercialized.

Recent Publications (more...)

Lee H, Castro CM
Thermophoretically enriched detection
Nat Biomed Eng. 2019;3:163-164 - DOI: 10.1038/s41551-019-0364-9
Bae SH, Jo A, Park JH, Lim CW, Choi Y, Oh J, Park JM, Kong T, Weissleder R, Lee H, Moon J
Bioassay for monitoring the anti-aging effect of cord blood treatment.
Theranostics. 2019;9(1):1-10 - PMID: 30662549 - PMCID: PMC6332798 - DOI: 10.7150/thno.30422
Fraser K, Jo A, Giedt J, Vinegoni C, Yang KS, Peruzzi P, Chiocca EA, Breakefield XO, Lee H, Weissleder R
Characterization of single microvesicles in plasma from glioblastoma patients.
Neuro Oncol. 2018;:ePub - PMID: 30561734 - DOI: 10.1093/neuonc/noy187
Zaborowski MP, Lee K, Na YJ, Sammarco A, Zhang X, Iwanicki M, Cheah PS, Lin HY, Zinter M, Chou CY, Fulci G, Tannous BA, Lai CP, Birrer MJ, Weissleder R, Lee H, Breakefield XO
Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles.
Cell Rep. 2019;27(1):255-268.e6 - PMID: 30943406 - DOI: 10.1016/j.celrep.2019.03.003

Recent News (more...)

2018-08-27: "AI-powered cancer diagnoses for resource limited settings" - CSB work is featured on the Nature Bioengineering blog.
2018-08-23: Hsing-Ying Lin (Lee Lab) has been selected to receive a MGH ECOR Fund for Medical Discovery (FMD) Postdoctoral Fellowship Award. Congratulations!
2018-06-18: Christopher T. Chan, Hsing-Ying Lin, and Jouha Min were named the winners of the 2018 MGH Research Fellow Poster Celebration. Congratulations!
2018-04-11: CSB work is featured on the MGH Blog.
2017-11-07: "Food Allergy Detection Device Could Remove Danger Of Dining Out" - CBS News report on the iEat device developed at CSB