Hakho Lee's Lab
Biomedical Engineering Program
- Thorough understanding of sensing mechanism. Before developing new detection systems, we put significant efforts in thoroughly studying their underlying physics. This critical task determines the feasibility of a proposed system, and estimates its fundamental limit.
- Engineering solution for robust operation. When implementing the actual systems, we strive to make them highly reliable and easy-to-use. Much emphasis is placed on system reproducibility, packaging, and user-interface.
- Multidisciplinary projects. We value working on multidisciplinary, large-scale projects that tackle challenging problems in biophysics and medicine. Such projects could be a venue for inspiring new technologies as well as expanding the use of emerging technologies. Researchers can also be motivated by new opportunities and interdisciplinary training, rather than being tunneled into a narrow specialty.
Many new diagnostic technologies have resulted from these efforts, and we are actively pursing their clinical translations.
Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance.
Integrated Magneto-Electrochemical Sensor for Exosome Analysis.
Recent Developments in Magnetic Diagnostic Systems
Chem Rev. 2015;115(19):10690-724 - PMID: 26258867
Rapid identification of health care–associated infections with an integrated fluorescence anisotropy system
Sci Adv. 2016;2(5):e1600300
2016-05-17: NIH Director Dr. Collins has selected CSB new paper in Science Advances on a system for rapid identification of health care-associated infections to be featured on his blog - https://directorsblog.nih.gov/. (pdf)
2016-04-07: Hyungsoon Im, PhD and Kisoo Park, PhD won Poster of Distinction awards at the 69th Annual Meeting of the MGH Scientific Advisory Committee (SAC). Congratulations!
2016-03-22: nPLEX is one of the greatest hits among 20 years of Nature Biotechnology biomedical research! (pdf)
2015-06-16: CSB developed nano-plasmonic exosome (”nPLEX”) technology won the Most promising translational research award given by CaNCURE Nanomedicine Program during their annual Nanomedicine Day.
2015-06-05: Divya Pathania, PhD received an award at the MGH ORCD 2015 Research Fellows Poster Celebration