Hakho Lee

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Hakho Lee’s Lab

Sensitive, fast and cost-effective diagnostic systems can have far-reaching implications in medicine and life sciences. My laboratory specializes in developing such sensors by bringing together ideas and techniques embodied in physics, engineering, and computation. Our research is guided by core principles – thorough understanding of underlying sensing mechanisms and providing robust engineering solutions. We further apply developed sensors to quantitatively analyze living systems. These efforts are key requisite for finding new biomarkers for early intervention as well as for developing targeted therapies.

Recent Publications (more...)

Lin HY, Huang CH, Park J, Pathania D, Castro CM, Fasano A, Weissleder R, Lee H
Integrated Magneto-Chemical Sensor For On-Site Food Allergen Detection.
ACS Nano. 2017;:ePub - PMID: 28792732
Yang KS*, Im H*, Hong S, Pergolini I, Del Castillo AF, Wang R, Clardy S, Huang CH, Pille C, Ferrone S, Yang R, Castro CM, Lee H, Del Castillo CF, Weissleder R
Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy
Sci Transl Med. 2017;9(391):eaal3226 - PMID: 28539469
Im H, Yang K, Lee H, Castro CM
Characterization of Extracellular Vesicles by Surface Plasmon Resonance.
Methods Mol Biol. 2017;1660:133-141 - PMID: 28828653

Recent News (more...)

2017-09-18: The work of Lee Lab on detecting and profiling circulating ovarian cancer cells is highlighted on the Congressionally Directed Medical Research Programs (CDMRP) site.
2017-04-06: Hakho Lee, PhD has been selected as a 2017 MGH Research Scholar. Congratulations, Hakho!
2016-06-01: Seonki Hong (Poster of Prestige), Chen-Han Huang (Poster of Merit), and Ashley Fenn (Poster of Distinction) received awards at 2016 MGH ORCD Research Fellows Poster Celebration. Congratulations!
2016-05-17: NIH Director Dr. Collins has selected CSB new paper in Science Advances on a system for rapid identification of health care-associated infections to be featured on his blog - https://directorsblog.nih.gov/. (pdf)