Hakho Lee

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Hakho Lee's Lab

Biomedical Engineering Program

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Highly sensitive, fast and cost-effective diagnostic systems can have far-reaching implications in medicine and life sciences. The primary goal of our laboratory is to develop such platforms by bringing together ideas and techniques embodied in physics and engineering. We further seek to apply the developed platforms to rigorously and quantitatively analyze living systems, with the ultimate aim of promoting human well-being. To achieve these goals, we are guided by the following principles:
Many new diagnostic technologies have resulted from these efforts, and we are actively pursing their clinical translations.

Recent Publications (more...)

Miller MA, Oudin MJ, Sullivan RJ, Wang SJ, Meyer AS, Im H, Frederick DT, Tadros J, Griffith LG, Lee H, Weissleder R, Flaherty KT, Gertler FB, Lauffenburger DA
Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance.
Cancer Discov. 2016;6(4):382-99 - PMID: 26984351 - Cover
Jeong S, Park J, Pathania D, Castro CM, Weissleder R, Lee H
Integrated Magneto-Electrochemical Sensor for Exosome Analysis.
ACS Nano. 2016;10(2):1802-1809 - PMID: 26808216 - PMCID: PMC4802494
Lee H, Shin TH, Cheon J, Weissleder R
Recent Developments in Magnetic Diagnostic Systems
Chem Rev. 2015;115(19):10690-724 - PMID: 26258867
Cho CF, Lee K, Speranza MC, Bononi FC, Viapiano MS, Luyt LG, Weissleder R, Chiocca EA, Lee H, Lawler SE
Design of a microfluidic chip for magnetic-activated sorting of one-bead-one-compound libraries.
ACS Comb Sci. 2016;:ePub - PMID: 27124678

Recent News (more...)

2016-04-07: Hyungsoon Im, PhD and Kisoo Park, PhD won Poster of Distinction awards at the 69th Annual Meeting of the MGH Scientific Advisory Committee (SAC). Congratulations!
2016-03-22: nPLEX is one of the greatest hits among 20 years of Nature Biotechnology biomedical research! (pdf)
2015-06-16: CSB developed nano-plasmonic exosome (”nPLEX”) technology won the Most promising translational research award given by CaNCURE Nanomedicine Program during their annual Nanomedicine Day.
2015-06-05: Divya Pathania, PhD received an award at the MGH ORCD 2015 Research Fellows Poster Celebration