Immunology

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Immunology Program

Funding

  • NCI
  • NHLBI
  • NIAID
  • AHA

The Immunology Program at CSB brings together investigators who conduct basic immunology research to understand complex disease processes. The program focuses on questions that are relevant to human health. Program members work closely within CSB but also maintain strong ties with other investigators at MGH, within the Harvard community, nationally and internationally. Program leaders emphasize the use of in vivo integrative and systems biology approaches as well as state-of-the-art imaging, surgical, genetic, cellular and molecular tools. Currently, major areas of interest include:

Immunology of atherosclerosis: Circulating leukocytes, among them monocytes, are essential to initiation, progression and complications of atherosclerosis. Monocytes are functionally heterogeneous and may play differential roles in disease. This program investigates how monocytes and their progeny contribute to atherosclerosis.

Immunology of myocardial infarction: Myocardial infarction triggers recruitment of diverse immune cell types (neutrophils, monocyte subtypes), which are critical for tissue repair. The program studies the regulation of immune responses to ischemic injury, and new therapeutic targets that can influence healing and post-MI ventricular remodeling.

Recent Publications (more...)

Nahrendorf M, Swirski FK
Cholesterol, CCR2, and monocyte phenotypes in atherosclerosis.
Eur Heart J. 2017;:ePub - PMID: 28329093
Swirski FK, Nahrendorf M
Inflammation: Old, caffeinated, and healthy.
Nat Rev Cardiol. 2017;14(4):194-196 - PMID: 28250451
Nairz M, Theurl I, Swirski FK, Weiss G
"Pumping iron" - how macrophages handle iron at the systemic, microenvironmental, and cellular levels.
Pflugers Arch. 2017;469(3-4):397-418 - PMID: 28251312

Recent News (more...)

2016-09-16: Circulation Research spotlights a profile of Matthias Nahrendorf, MD PhD and his research. (pdf)
2016-07-14: CSB work is highlighted in Nature Reviews Cardiology. (pdf)
2016-06-01: Seonki Hong (Poster of Prestige), Chen-Han Huang (Poster of Merit), and Ashley Fenn (Poster of Distinction) received awards at 2016 MGH ORCD Research Fellows Poster Celebration. Congratulations!
2016-04-06: Fil Swirski, PhD has been selected as a 2016 MGH Research Scholar. Congratulations, Fil!
2016-03-21: An immune cell that protects against cancer. Macrophages are mostly viewed as tumor-promoting cells. They can infiltrate solid tumors in high numbers, and their presence at the tumor site is often associated with decreased patient survival. However, much less is known about macrophages located outside the tumor stroma. Mikael Pittet and colleagues now show that a population of lymph node macrophages, called subcapsular sinus (SCS) macrophages, unexpectedly protects against melanoma. The study was published in Science on March 17, 2016 and is available for download.