Immunology

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Immunology Program

Funding

  • NCI
  • NHLBI
  • NIAID
  • AHA

The Immunology Program at CSB brings together investigators who conduct basic immunology research to understand complex disease processes. The program focuses on questions that are relevant to human health. Program members work closely within CSB but also maintain strong ties with other investigators at MGH, within the Harvard community, nationally and internationally. Program leaders emphasize the use of in vivo integrative and systems biology approaches as well as state-of-the-art imaging, surgical, genetic, cellular and molecular tools. Currently, major areas of interest include:

Immunology of atherosclerosis: Circulating leukocytes, among them monocytes, are essential to initiation, progression and complications of atherosclerosis. Monocytes are functionally heterogeneous and may play differential roles in disease. This program investigates how monocytes and their progeny contribute to atherosclerosis.

Immunology of myocardial infarction: Myocardial infarction triggers recruitment of diverse immune cell types (neutrophils, monocyte subtypes), which are critical for tissue repair. The program studies the regulation of immune responses to ischemic injury, and new therapeutic targets that can influence healing and post-MI ventricular remodeling.

Recent Publications (more...)

Braza MS, van Leent MMT, Lameijer M, Sanchez-Gaytan BL, Arts RJW, Pérez-Medina C, Conde P, Garcia MR, Gonzalez-Perez M, Brahmachary M, Fay F, Kluza E, Kossatz S, Dress RJ, Salem F, Rialdi A, Reiner T, Boros P, Strijkers GJ, Calcagno CC, Ginhoux F, Marazzi I, Lutgens E, Nicolaes GAF, Weber C, Swirski FK, Nahrendorf M, Fisher EA, Duivenvoorden R, Fayad ZA, Netea MG, Mulder WJM, Ochando J
Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance.
Immunity. 2018;49(5):819-828.e6 - PMID: 30413362 - PMCID: PMC6251711 - DOI: 10.1016/j.immuni.2018.09.008
Fayad ZA, Swirski FK, Calcagno C, Robbins CS, Mulder W, Kovacic JC
Monocyte and Macrophage Dynamics in the Cardiovascular System: JACC Macrophage in CVD Series (Part 3).
J Am Coll Cardiol. 2018;72(18):2198-2212 - PMID: 30360828 - PMCID: PMC6258199 - DOI: 10.1016/j.jacc.2018.08.2150
Frodermann V, Nahrendorf M
Macrophages and Cardiovascular Health.
Physiol Rev. 2018;98(4):2523-2569 - PMID: 30156496 - DOI: 10.1152/physrev.00068.2017

Recent News (more...)

2018-05-10: "Leaders In Cardiovascular Science" - Circulation Research profiles Fil Swirski. (pdf)
2017-06-05: CSB work is profiled in MGH Research Institute spotlight "Mass General Researchers Investigate the ‘Big Eaters’ of the Immune System: #MacrophageMonday"
2017-04-26: Congratulations to Dr. Camilla Engblom, from the Pittet laboratory, for brillantly completing her PhD thesis work entitled “Cancer-host interactions influencing disease progression and therapy”. Dr. Engblom graduated from the PhD Program in Immunology at Harvard Medical School.
2016-09-16: Circulation Research spotlights a profile of Matthias Nahrendorf, MD PhD and his research. (pdf)
2016-07-14: CSB work is highlighted in Nature Reviews Cardiology. (pdf)