Immunology

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Immunology Program

Funding

  • NCI
  • NHLBI
  • NIAID
  • AHA

The Immunology Program at CSB brings together investigators who conduct basic immunology research to understand complex disease processes. The program focuses on questions that are relevant to human health. Program members work closely within CSB but also maintain strong ties with other investigators at MGH, within the Harvard community, nationally and internationally. Program leaders emphasize the use of in vivo integrative and systems biology approaches as well as state-of-the-art imaging, surgical, genetic, cellular and molecular tools. Currently, major areas of interest include:

Immunology of atherosclerosis: Circulating leukocytes, among them monocytes, are essential to initiation, progression and complications of atherosclerosis. Monocytes are functionally heterogeneous and may play differential roles in disease. This program investigates how monocytes and their progeny contribute to atherosclerosis.

Immunology of myocardial infarction: Myocardial infarction triggers recruitment of diverse immune cell types (neutrophils, monocyte subtypes), which are critical for tissue repair. The program studies the regulation of immune responses to ischemic injury, and new therapeutic targets that can influence healing and post-MI ventricular remodeling.

Recent Publications (more...)

Hoogeveen RM, Nahrendorf M, Riksen NP, Netea MG, de Winther MPJ, Lutgens E, Nordestgaard B, Neidhart M, Stroes ESG, Catapano AL, Bekkering S
Monocyte and haematopoietic progenitor reprogramming as common mechanism underlying chronic inflammatory and cardiovascular diseases.
Eur Heart J. 2017;:ePub - PMID: 29069365
Nairz M, Haschka D, Dichtl S, Sonnweber T, Schroll A, Aßhoff M, Mindur JE, Moser PL, Wolf D, Swirski FK, Theurl I, Cerami A, Brines M, Weiss G
Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis.
Sci Rep. 2017;7(1):13012 - PMID: 29026145 - PMCID: PMC5638901
Anzai A, Choi JL, He S, Fenn AM, Nairz M, Rattik S, McAlpine CS, Mindur JE, Chan CT, Iwamoto Y, Tricot B, Wojtkiewicz GR, Weissleder R, Libby P, Nahrendorf M, Stone JR, Becher B, Swirski FK
The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes.
J Exp Med. 2017;214(11):3293-3310 - PMID: 28978634 - PMCID: PMC5679174

Recent News (more...)

2017-06-05: CSB work is profiled in MGH Research Institute spotlight "Mass General Researchers Investigate the ‘Big Eaters’ of the Immune System: #MacrophageMonday"
2017-04-26: Congratulations to Dr. Camilla Engblom, from the Pittet laboratory, for brillantly completing her PhD thesis work entitled “Cancer-host interactions influencing disease progression and therapy”. Dr. Engblom graduated from the PhD Program in Immunology at Harvard Medical School.
2016-09-16: Circulation Research spotlights a profile of Matthias Nahrendorf, MD PhD and his research. (pdf)
2016-07-14: CSB work is highlighted in Nature Reviews Cardiology. (pdf)
2016-06-01: Seonki Hong (Poster of Prestige), Chen-Han Huang (Poster of Merit), and Ashley Fenn (Poster of Distinction) received awards at 2016 MGH ORCD Research Fellows Poster Celebration. Congratulations!