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Position: Postdoctoral Research Fellow

Research Area: Renal Division

Full/Part Time: Full Time

Investigator: Lu, Jenny (Hua)

Date Posted: 2018-12-05

Description: Two postdoctoral positions are available in the laboratory of Dr. Hua Jenny Lu at the Renal Division, Department of Medicine at the Massachusetts General Hospital/Harvard Medical School.  These positions will focus on one of these three projects. Project 1: Study integrin-extracellular matrix signaling in kidney tubular epithelial cells structure, function, and remodeling after injury. To understand how renal tubular injury causes interstitial inflammation and fibrosis. Project 2: Investigate the regulatory mechanism of trafficking of water channels aquaporin 2 and 3, in normal physiology and disease pathology. Explore therapeutic strategy for treating diabetes insipidus and hyponatremia. Project 3: Characterize the function of a novel gene in regulating kidney inflammation and podocyte metabolism. Understand how its deficiency leads to inflammation and development of proteinuria kidney diseases. We are applying comprehensive and cutting edge technologies, using various in vitro, exo vivo and transgenic animal models to interrogate mechanism of kidney injury and repair. If interested, please submit your CV, contact information and list of three referees to Dr. Jenny Lu at lu.hua@mgh.harvard.edu

Requirements: The candidates must hold a PhD or/and MD degree within cell biology, molecular biology, biochemistry, physiology or/and pathology. Prior experience with cell culture, basic biochemical techniques, immunocytochemistry, western blotting and qRT-PCR is essential. Experience with animal study is an advantage. Candidates must be self-motivated. Being a US citizen or a green card holder is an advantage.


Position: Research Technician

Research Area: Immunocytochemistry for a Microscopy Core Facility

Full/Part Time: Full Time

Investigator: Brown, Dennis

Date Posted: 2018-12-04

Description: The Center for Systems Biology and Program in Membrane Biology (PMB) at the Massachusetts General Hospital and Harvard Medical School is currently accepting applications for an open Research Technician I position. The candidate will be responsible for a variety of procedures related to our Microscopy Core Facility. The facility serves the imaging needs of PMB faculty as well as many external users from MGH and other local institutions. The work is varied, and involves preparing and imaging cell and tissue samples from many different sources and species. The techniques used include tissue sectioning, immunofluorescence staining, digital imaging using conventional and laser scanning confocal microscopy, and image analysis using various software packages.

Responsibilities: Interested candidates should send an updated CV, complete contact information for two references, and a cover letter describing their past experience to, brown.dennis @mgh.harvard.edu.

Requirements: Minimum of a Bachelor’s degree plus the equivalent of one year of directly related experience is required. The candidate must have excellent laboratory skills with a preference for some experience in immunostaining and microscopy. Training in more sophisticated techniques such as confocal imaging will be offered if necessary. Candidates will be working in a dynamic, multidisciplinary research environment and must therefore have excellent English written and oral communication skills, as well as capacity for teamwork. Because the position involves working with many different Core users and clients, the candidate must have excellent social interaction skills and must be able to juggle several projects simultaneously.


Position: Research Technician

Research Area: Cancer Genetics and Tumor Evolution

Full/Part Time: Full Time

Investigator: Naxerova, Kamila

Date Posted: 2018-11-19

Description: A research technician position is available in the Naxerova laboratory at the Center for Systems Biology at Massachusetts General Hospital and Harvard Medical School. The Naxerova lab studies the evolutionary history of cancer, using a blend of high-throughput experimental and computational approaches. We are interested in understanding how processes of mutation and selection in normal (stem) cells set the stage for cancer evolution. Once a tumor develops, how does tissue-specific selection shape the cancer genome? How can we take advantage of genetic intra-tumor heterogeneity to gain insights into the life history of a cancer? A particular interest of the lab is metastasis evolution. Do metastases arise from distinct clones with special, genetically encoded properties or do they represent random samples of the primary tumor? Do all metastases arise independently from the primary tumor, or do they give rise to each other? Does metastatic spread happen early or late in tumor development? Perhaps most importantly, is there a correlation between the evolutionary history of metastases and clinical outcomes? These questions are difficult to study in humans because it is challenging to reconstruct occult events that happened years before diagnosis. We are developing and applying new methods for lineage tracing in human cancer, with the ultimate goal of understanding a tumor’s entire evolution from the founder cell to lethal systemic disease.

Responsibilities: We are looking for a motivated research technician to participate in projects investigating metastasis patterns in colorectal cancer and melanoma. Apart from getting a solid theoretical foundation in cancer genetics, you will learn how to evaluate human tumor samples histologically, how to collect tissue material and isolate DNA from it, how to run high-throughput PCRs and how to analyze the resulting data in R and Python. Thus, you will be exposed to a variety of experimental and bioinformatic methods, which will be useful if you want to apply to graduate school at a later point in time. Our team is very collaborative and friendly.

Requirements: The candidate should have a Bachelor’s degree and lab experience.


Position: Postdoctoral Research Fellow

Full/Part Time: Full Time

Investigator: Breton, Sylvie

Date Posted: 2018-11-09

Description: A post-doctoral position is available in an NIH funded research laboratory of the Massachusetts General Hospital / Harvard Medical School. Successful applicant will focus on post-testicular regulation of male fertility by examining the cell biology of epithelial cells in the epididymis and vas deferens, using a multidisciplinary approach including laser scanning confocal microscopy, in vivo multiphoton microscopy, in vivo luminal perfusion of the epididymis, and biochemical and molecular biology techniques.

Responsibilities: Please send a CV and list of three references to Dr. Sylvie Breton: Breton.sylvie@mgh.harvard.edu The Massachusetts General Hospital and Harvard Medical School are affirmative action, equal opportunity employers. Applications from minorities are encouraged.

Requirements: The candidate should have a PhD or MD/PhD degree. Priority will be given to candidates that have obtained their degree less than two years ago and have demonstrated research productivity. Expertise in the generation of transgenic mice is required. Excellent verbal and written communication skills are preferred.


Position: Postdoctoral Research Fellow

Research Area: Cancer genetics

Full/Part Time: Full Time

Investigator: Naxerova, Kamila

Date Posted: 2018-10-15

Description: The Naxerova lab studies the evolutionary history of cancer, using a blend of high-throughput experimental and computational approaches. We are interested in understanding how processes of mutation and selection in normal (stem) cells set the stage for cancer evolution. Once a tumor develops, how does tissue-specific selection shape the cancer genome? How can we take advantage of genetic intra-tumor heterogeneity to gain insights into the life history of a cancer? A particular interest of the lab is metastasis evolution. Do metastases arise from distinct clones with special, genetically encoded properties or do they represent random samples of the primary tumor? Do all metastases arise independently from the primary tumor, or do they give rise to each other? Does metastatic spread happen early or late in tumor development? Perhaps most importantly, is there a correlation between the evolutionary history of metastases and clinical outcomes? These questions are difficult to study in humans because it is challenging to reconstruct occult events that happened years before diagnosis. We are developing and applying new methods for lineage tracing in human cancer, with the ultimate goal of understanding a tumor’s entire evolution from the founder cell to lethal systemic disease.

Responsibilities: We have exciting new projects investigating metastasis patterns in colorectal cancer and melanoma and are looking a postdoctoral fellow or PhD student to join the team. Both experimentally and computationally inclined candidates are encouraged to apply. We are implementing experimental methods that generate large amounts of complex data and can thus offer fertile playing grounds to both experimentalists and bioinformaticians.

Requirements: There are no specific requirements for the job – we can teach you all the specifics here – but you should really burn for cancer genetics, enjoy grappling with difficult problems, be friendly and collegial, and have a track record in academic science that shows your commitment to this line of work.


Position: Postdoctoral Research Fellow

Research Area: Multiscale Network Biology

Full/Part Time: Full Time

Investigator: Miller, Miles

Date Posted: 2018-07-17

Description: The Center for Systems Biology (csb.mgh.harvard.edu) has an immediate opening for a position within the Multiscale Network Biology Program, https://csb.mgh.harvard.edu/miller. The Center for Systems Biology is located within the Simches Research building on the main MGH campus, and features a dynamic, multi-disciplinary environment with close interactions with MGH clinician-researchers and investigators across Harvard and MIT. We offer excellent training opportunities in a young, dynamic and highly collaborative research environment including chemistry, chemical biology, molecular biology, systems biology, imaging and cancer research. All interested applicants should submit a CV and two letters of reference to Serena Sullivan (sullivan.serena@mgh.harvard.edu). 

Responsibilities: The candidate will be trained in advanced network analysis and image processing techniques including in vivo microscopy, image segmentation and morphometry, systems pharmacology, and multivariate analysis of large datasets.

Requirements: PhD is preferred but we will consider candidates with a MS and experience. A strong background in computational modeling and excellent command of spoken and written English are essential. Prior experience in cancer cell biology is a plus.


Position: Postdoctoral Research Fellow

Research Area: Cardiovascular Immunology / Hematology

Full/Part Time: Full Time

Investigator: Nahrendorf, Matthias

Date Posted: 2018-07-17

Description: We are looking to recruit a highly motivated team player who enjoys creative thinking and problem solving. If you love science, consider joining our dynamic interdisciplinary research group at the Center for Systems Biology. We are a group of 10 scientists and focus on the role of immunity and hematopoiesis in the setting of cardiovascular disease. Of particular interest are the production of innate immune cells by the hematopoietic system, and the signals that regulate leukocyte supply after ischemic injuries such as myocardial infarction or stroke. Most of our work is done in mice, but we increasingly also work with human samples. Recent publications: Nahrendorf M. Myeloid cell contributions to cardiovascular health and disease. Nature Med. 2018;24(6):711-720 - PMID: 29867229 Hulsmans M et al. Macrophages Facilitate Electrical Conduction in the Heart Cell. 2017;169:510-522 - PMID: 28431249

Requirements: Experience in immunology, hematology, intravital microscopy or gene editing is a plus but not a must.


Position: Research Technician

Full/Part Time: Full Time

Investigator: Babitt, Jodie

Date Posted: 2018-06-20

Description: A bright and motivated RESEARCH TECHNICIAN is being sought for the Babitt Lab in the Nephrology Division at Massachusetts General Hospital. The focus of the laboratory is to study how cells and organisms regulate their iron content and how this process goes awry in many common diseases from anemia of chronic kidney disease to the genetic iron overload disorder hereditary hemochromatosis to iron loading anemias such as thalassemia.

Responsibilities: This work will involve performing molecular and cellular biology experiments including tissue culture, RNA isolation, conventional and real-time PCR, Western blot, immunohistochemistry. This work will also involve rodent animal studies, including maintenance and breeding of mouse colonies and genotyping. The candidate will also have general lab responsibilities including record keeping and ordering supplies.

Requirements: • Mouse breeding and genotyping • Tissue culture • Basic cell, molecular biology and biochemistry techniques such as gene cloning, protein expression and purification, Western blot, PCR, qRT-PCR, • Excellent communication, organization, documentation, and problem solving skills • Ability to multi-task, work in a team environment, and work independently • Demonstrate honesty, integrity and reliability • Positive attitude and willingness to learn and grow Required:  Bachelor's Degree with training in biological sciences.  Some lab experience in addition to school lab experience is highly desirable.


Position: Postdoctoral Research Fellow

Research Area: Molecular profiling of cancer cells and microscopy

Full/Part Time: Full Time

Investigator: Weissleder, Ralph

Date Posted: 2017-10-11

Description: The labs of Ralph Weissleder and Hakho Lee in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School invite applications for Postdoctoral Research Fellow positions. One or two positions are available in molecular profiling of cancer cells (see Sci Transl Med. 2014;6(219):219ra9). The ideal candidate should have a background in microfluidics, optics (microscopy), protein/DNA diagnostics, and cell biology, with expertise in system implementation and benchwork. The Center (csb.mgh.harvard.edu) has a diverse faculty with backgrounds in engineering, chemistry, biology, physics, and medicine, and offers a lively and supportive environment in which to perform interdisciplinary science.

Responsibilities: We seek creative thinkers who take risks in defining and addressing important problems, and who use quantitative experimental, computational and/or theoretical approaches in their work. Research fellows are encouraged to write their own grants, following the training period, to launch their independent research.

Requirements: A Ph.D., M.D./Ph.D. or M.D. and permanent residency is required. To apply, please send your CV, a summary of your most significant research accomplishments (300 words) and the email addresses of three references to: Serena Sullivan (Sullivan.Serena@mgh.harvard.edu), CSB, Simches Research Center, 185 Cambridge Street, Suite 5.210, Boston, MA 02114.


Position: Postdoctoral Research Fellow

Research Area: Cell Biology

Full/Part Time: Full Time

Investigator: Weissleder, Ralph

Date Posted: 2017-10-11

Description: The Weissleder lab in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School invites applications for Postdoctoral Research Fellow positions. One position is available in molecular profiling of cancer cells (see Sci Transl Med. 2014;6(219):219ra9). The Center has a diverse faculty with backgrounds in chemistry, biology, physics, engineering and medicine, and offers a lively and supportive environment in which to perform interdisciplinary science.

Responsibilities: We seek creative thinkers who take risks in defining and addressing important problems, and who use quantitative experimental, computational and/or theoretical approaches in their work.

Requirements: A Ph.D., M.D./Ph.D. or M.D. and permanent residency is required. The ideal candidate has a background in protein/DNA diagnostics, cell biology, or molecular biology and has performed extensive benchwork in the past. To apply, please send your CV, a summary of your most significant research accomplishments (300 words) and the email addresses of three references to: Serena Sullivan (Sullivan.Serena@mgh.harvard.edu), CSB, Simches Research Center, 185 Cambridge Street, Suite 5.210, Boston, MA 02114.


Position: Postdoctoral Research Fellow

Research Area: Synthetic chemistry

Full/Part Time: Full Time

Investigator: Weissleder, Ralph

Date Posted: 2017-10-11

Description: The Weissleder lab in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School invites applications for Postdoctoral Research Fellow positions. One position is available in chemical synthesis of small molecules and bioconjugation. The Center has a diverse faculty with backgrounds in chemistry, biology, physics, engineering and medicine, and offers a lively and supportive environment in which to perform interdisciplinary science.

Responsibilities: We seek creative thinkers who take risks in defining and addressing important problems, and who use quantitative experimental, computational and/or theoretical approaches in their work.

Requirements: A Ph.D., M.D./Ph.D. or M.D. and permanent residency is required. The ideal candidate has an extensive synthetic background and track record in chemical syntheses and analyses. To apply, please send your CV, a summary of your most significant research accomplishments (300 words) and the email addresses of three references to: Serena Sullivan (Sullivan.Serena@mgh.harvard.edu), CSB, Simches Research Center, 185 Cambridge Street, Suite 5.210, Boston, MA 02114.


Send your application to (please specify position): Serena Sullivan (Sullivan.Serena@mgh.harvard.edu), CSB, Simches Research Center, 185 Cambridge Street, Suite 5.210, Boston, MA 02114

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability status, protected veteran status, or any other characteristics protected by law.