Investigator / Platform Research Area Position
Weissleder, Ralph Synthetic chemistry Postdoctoral Research Fellow
Weissleder, Ralph Computational cell analysis Postdoctoral Research Fellow
Weissleder, Ralph Exosome analysis Postdoctoral Research Fellow
Weissleder, Ralph Single cell profiling of the tumor microenvironment Postdoctoral Research Fellow
Pai, Sara Immuno-oncology and head and neck cancer Research Scientist
Naxerova, Kamila Cancer Genetics and Tumor Evolution Research Technician I
Naxerova, Kamila Cancer genetics and tumor evolution Postdoctoral Research Fellow
Naxerova, Kamila Bioinformatics Research Technician II
Lee, Hakho System engineering and development Postdoctoral Research Fellow
Im, Hyungsoon Artificial intelligence, deep learning, computer science Postdoctoral Research Fellow
Im, Hyungsoon Engineering, Extracellular vesicles, Neuroscience Postdoctoral Research Fellow
Chen, John Neuroinflammatory Diseases Research Technician
Chen, John Neuroinflammatory Diseases Postdoctoral Research Fellow
Training Faculty Cancer research through innovative systems approaches T32 Postdoctoral fellow
Faculty Pathology Assistant Professor of Pathology
More information:

Position: Postdoctoral Research Fellow

Research Area: Single cell profiling of the tumor microenvironment

Full/Part Time: Full Time

Investigator: Weissleder, Ralph

Date Posted: 2021-09-24

Description: The lab of Ralph Weissleder in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School has a number of openings for Postdoctoral Research Fellows. The ideal candidate should have a background in microscopy, cell culture and immunology with expertise in system implementation and benchwork. The Center (csb.mgh.harvard.edu) has a diverse faculty with backgrounds in engineering, chemistry, biology, physics, and medicine, and offers a lively and supportive environment in which to perform interdisciplinary science.

Responsibilities: We seek creative thinkers who take risks in defining and addressing important problems, and who use quantitative experimental, computational and/or theoretical approaches in their work. Research fellows are encouraged to write their own grants, following the training period, to launch their independent research.

Requirements: A Ph.D., M.D./Ph.D. or M.D. and permanent residency is required. To apply, please send your CV, a summary of your most significant research accomplishments (300 words) and the email addresses of three references to: Serena Sullivan (Sullivan.Serena@mgh.harvard.edu), CSB, Simches Research Center, 185 Cambridge Street, Suite 5.210, Boston, MA 02114.

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Position: Postdoctoral Research Fellow

Research Area: Exosome analysis

Full/Part Time: Full Time

Investigator: Weissleder, Ralph

Date Posted: 2021-09-24

Description: The lab of Ralph Weissleder (https://csb.mgh.harvard.edu/weissleder) in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School invites applications for Postdoctoral Research Fellow positions. A position is available in single cell and exosome analysis. Ideal candidates should have a strong academic background, US training and prior publications. The Center has a diverse faculty and offers a lively and supportive environment in which to perform interdisciplinary science.

Responsibilities: We seek creative thinkers who take risks in defining and addressing important problems, and who use quantitative experimental, computational and/or theoretical approaches in their work. Research fellows are encouraged to write their own grants, following the training period, to launch their independent research.

Requirements: A Ph.D., or M.D./Ph.D. and permanent residency is required. To apply, please send your CV, a summary of your most significant research accomplishments (300 words) and the email addresses of three references to: Serena Sullivan Sullivan.Serena@mgh.harvard.edu.

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Position: Postdoctoral Research Fellow

Research Area: Computational cell analysis

Full/Part Time: Full Time

Investigator: Weissleder, Ralph

Date Posted: 2021-09-24

Description: The lab of Ralph Weissleder (https://csb.mgh.harvard.edu/weissleder) in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School invites applications for Postdoctoral Research Fellow positions. One position is available in computational single cell analysis, spatial profiling, temporal profiling and modeling. Ideal candidates should have a strong academic background, US training and prior publications. The Center has a diverse faculty and offers a lively and supportive environment in which to perform interdisciplinary science.

Responsibilities: We seek creative thinkers who take risks in defining and addressing important problems, and who use quantitative experimental, computational and/or theoretical approaches in their work. Research fellows are encouraged to write their own grants, following the training period, to launch their independent research.

Requirements: A Ph.D., or M.D./Ph.D. and permanent residency is required. To apply, please send your CV, a summary of your most significant research accomplishments (300 words) and the email addresses of three references to: Serena Sullivan Sullivan.Serena@mgh.harvard.edu.

Apply

Position: Research Technician II

Research Area: Bioinformatics

Full/Part Time: Full Time

Investigator: Naxerova, Kamila

Date Posted: 2021-08-03

Description: A research technician or data analyst position is available in the Nahrendorf and Naxerova laboratories at the Center for Systems Biology at Massachusetts General Hospital and Harvard Medical School. If you are a motivated scientist with a Bachelor’s or Master’s degree in computational biology, bioinformatics, statistics or related relevant fields, and you want to be part of a dynamic, friendly team that produces and analyzes a large amount of complex data (bulk and single cell RNA sequencing data), please consider applying! We have a multitude of interesting projects in cardiovascular disease research that will provide a rich playing ground for a person who enjoys thinking about data and its (biological) implications. We are looking for somebody who will actively be engaged in the research and take responsibility for their projects. This is not a job in which you will be told what to do step by step. Please review these websites to learn more about our research: https://csb.mgh.harvard.edu/naxerova https://csb.mgh.harvard.edu/nahrendorf

Responsibilities: After a thorough training phase, you will work independently and be able to realize your own ideas. You will be embedded into a great research team with lots of support, both from the biological as well as from the bioinformatics side.

Requirements: Bachelor’s or Master’s degree in computational biology, bioinformatics, statistics or related relevant fields Recent graduates who are looking to earn a few years of research experience before applying to graduate school are particularly welcome.

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Position: Postdoctoral Research Fellow

Research Area: Cancer genetics and tumor evolution

Full/Part Time: Full Time

Investigator: Naxerova, Kamila

Date Posted: 2021-08-03

Description: Two postdoctoral positions in cancer genetics are available in the Naxerova laboratory at the Center for Systems Biology at Massachusetts General Hospital and Harvard Medical School. The Naxerova lab studies the evolutionary history of cancer, using a blend of high-throughput experimental and computational approaches. We are interested in understanding how processes of mutation and selection in normal (stem) cells set the stage for cancer evolution. Once a tumor develops, how does tissue-specific selection shape the cancer genome? How can we take advantage of genetic intra-tumor heterogeneity to gain insights into the life history of a cancer? A particular interest of the lab is metastasis evolution. Do metastases arise from distinct clones with special, genetically encoded properties or do they represent random samples of the primary tumor? Do all metastases arise independently from the primary tumor, or do they give rise to each other? Does metastatic spread happen early or late in tumor development? Perhaps most importantly, is there a correlation between the evolutionary history of metastases and clinical outcomes? These questions are difficult to study in humans because it is challenging to reconstruct occult events that happened years before diagnosis. We are developing and applying new methods for lineage tracing in human cancer, with the ultimate goal of understanding a tumor’s entire evolution from the founder cell to lethal systemic disease. We have exciting new projects in the works and are looking for two postdoctoral fellows to join the team. Both experimentally and computationally inclined candidates are encouraged to apply. We are implementing experimental methods that generate large amounts of complex data and can thus offer fertile playing grounds to both experimentalists and bioinformaticians. The ideal candidate should be interested in doing some amount of both. To apply, please send a brief (less than 1 page) statement describing your interest in cancer genetics and your CV to Kamila Naxerova (naxerova.kamila@mgh.harvard.edu). Please check out the lab website csb.mgh.harvard.edu/naxerova for more information about publications and current lab members. We are a friendly, motivated team that is looking forward to hearing from you! The Center for Systems Biology (CSB), a multidisciplinary thematic center at Massachusetts General Hospital and Harvard Medical School, houses a vibrant scientific community united by its interest in integrative, quantitative biology and translational medicine. CSB and the larger Harvard community in which it is embedded offer near limitless opportunities for education and interdisciplinary collaboration. MGH offers excellent benefits to all employees and is an equal opportunity employer.

Requirements: There are no specific requirements for the job – we can teach you all the specifics here – but you should really burn for cancer genetics, enjoy grappling with difficult problems, be friendly and collegial, and have a track record in academic science that shows your commitment to this line of work.

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Position: Postdoctoral Research Fellow

Research Area: Engineering, Extracellular vesicles, Neuroscience

Full/Part Time: Full Time

Investigator: Im, Hyungsoon

Date Posted: 2021-08-03

Description: The Im Lab in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School seeks highly motivated postdoctoral research scholars to develop next-generation diagnostic technologies for clinical translation. The candidate will work in a highly collaborative laboratory of several postdoc members with backgrounds in engineering, computer science, biology, chemistry, and medicine. The laboratory provides a supportive research environment working with clinicians in the hospital and industry partners.

Responsibilities: An ideal candidate has expertise in one or more of the following areas: Engineering, Optics (microscopy), Microfluidics, Organ-on-a-chip, Extracellular Vesicles, Biology, Chemistry, Neuroscience, Cell Biology, Computer Science, or relevant areas.

Requirements: We seek motivated and creative individuals with a Ph.D. or M.D./Ph.D. degree. To apply, please send your CV, a summary of your most significant research accomplishments, and the email addresses of two references to: Hyungsoon Im (im.hyungsoon@mgh.harvard.edu).

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Position: Postdoctoral Research Fellow

Research Area: System engineering and development

Full/Part Time: Full Time

Investigator: Lee, Hakho

Date Posted: 2021-08-03

Description: The Lee laboratory at Center for Systems Biology, Massachusetts General Hospital is recruiting a research fellow (PhD level) in the field described below. • Fields: Systems engineering (Experience in microscopy, plasmonics, biosensor and/or related projects is preferred). • Skill sets: System development (optical setup, electronics, and computer control), microscopy, circuit design and prototyping, bioassays (e.g., ELISA, microscopy)

Responsibilities: The candidate will work with other team members to lead the development of new diagnostic or imaging systems to analyze extracellular vesicles or other analytical targets.

Requirements: (i) Academic degree holders (including prospective graduation by Fall 2020). (ii) Good verbal and written communication skills in English. (iii) High impact publications from previous research period. (iv) Minimum commitment of two years.

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Position: Postdoctoral Research Fellow

Research Area: Artificial intelligence, deep learning, computer science

Full/Part Time: Full Time

Investigator: Im, Hyungsoon

Date Posted: 2021-08-03

Description: A postdoctoral research position is available in the laboratory of Dr. Hyungsoon Im in the Center for Systems Biology (CSB) at the Massachusetts General Hospital (MGH), Harvard Medical School. We are interested in candidates with research background in artificial intelligence, deep learning, computer science, and relevant areas. We have active projects developing and applying AI algorithms for medical and microscopic imaging as well as their clinical translation.

Responsibilities: Expertise in one or more of the following areas is desired but not required: computer science, bioinformatics, engineering or relevant areas. The ideal candidate will have interest in the development of new deep-learning algorithms based on medical data and their applications in translational medicine.

Requirements: We seek motivated and creative individuals with a Ph.D. or M.D./Ph.D. degree. To apply, please send your CV, a summary of your most significant research accomplishments (300 words) and the email addresses of three references to: Hyungsoon Im (im.hyungsoon@mgh.harvard.edu), Simches Research Center, 185 Cambridge Street, Suite 5.210, Boston, MA 02114.

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Position: Research Technician I

Research Area: Cancer Genetics and Tumor Evolution

Full/Part Time: Full Time

Investigator: Naxerova, Kamila

Date Posted: 2021-08-03

Description: A joint research technician position between the Center for Integrated Diagnostics and the Naxerova laboratory at the Center for Systems Biology at Massachusetts General Hospital is available! The Naxerova lab studies the evolutionary history of cancer, using a blend of high-throughput experimental and computational approaches. We are interested in understanding how processes of mutation and selection in normal (stem) cells set the stage for cancer evolution. Once a tumor develops, how does tissue-specific selection shape the cancer genome? How can we take advantage of genetic intra-tumor heterogeneity to gain insights into the life history of a cancer? A particular interest of the lab is metastasis evolution. Do metastases arise from distinct clones with special, genetically encoded properties or do they represent random samples of the primary tumor? Do all metastases arise independently from the primary tumor, or do they give rise to each other? Does metastatic spread happen early or late in tumor development? Perhaps most importantly, is there a correlation between the evolutionary history of metastases and clinical outcomes? These questions are difficult to study in humans because it is challenging to reconstruct occult events that happened years before diagnosis. We are developing and applying new methods for lineage tracing in human cancer, with the ultimate goal of understanding a tumor’s entire evolution from the founder cell to lethal systemic disease. To apply, please send your CV to Kamila Naxerova (naxerova.kamila@mgh.harvard.edu). Please also check out the lab website csb.mgh.harvard.edu/naxerova and the CID website (https://www.massgeneral.org/pathology/services/center-for-integrated-diagnostics-default) for more information about publications and current lab members.

Responsibilities: We are looking for a motivated research technician to participate in projects investigating metastasis patterns in colorectal cancer and melanoma. Apart from getting a solid theoretical foundation in cancer genetics, you will learn how to evaluate human tumor samples histologically and how to collect tissue material and isolate DNA from it. You will also be analyzing complex data in R and Python. Thus, you will be exposed to a variety of experimental and bioinformatic methods, which will be useful if you want to apply to graduate or medical school at a later point in time. Our team is very collaborative and friendly. Part of your time will be spent in the Center for Integrated Diagnostics (CID) where you will work with clinicians and participate in clinical workflows. The position really is a perfect mix of different challenges.

Requirements: Bachelor’s degree and lab experience

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Position: Postdoctoral Research Fellow

Research Area: Neuroinflammatory Diseases

Full/Part Time: Full Time

Investigator: Chen, John

Date Posted: 2021-08-03

Description: We are looking for enthusiastic and bright postdoctoral fellows to join a translational imaging laboratory to conduct research in neuroinflammatory diseases at the Massachusetts General Hospital (MGH). Our laboratory works on the discovery and development of novel diagnostic and therapeutic agents to track and treat against inflammation in a variety of CNS disorders in preclinical models and seek to apply the findings in clinical settings. Our work had been published in Science, PNAS, Brain, JCI, and Radiology. The successful candidate will be a talented researcher with strong motivation to pursue independent research. Dr. Chen’s laboratory is affiliated with the Center for Systems Biology (https://csb.mgh.harvard.edu), a major thematic center at MGH, and the Institute for Innovation in Imaging (https://i3.mgh.harvard.edu), a center focused on enabling translation of novel diagnostic technologies at MGH, the latter of which Dr. Chen also co-directs. In addition to a strong funding record, Dr. Chen has a strong mentoring record, including being the primary mentor for multiple NIH K-awards awarded to his former fellows. The fellow will have an excellent environment to not only perform state-of-the-art research but also opportunities to learn from and interact with world-renowned scientists at both centers, as well as MGH and the greater Harvard community.

Requirements: • Ph.D. (or equivalent) in neuroscience, systems biology, computational biology, biochemistry, or any related field. • Experience with animal models of stroke or Alzheimer’s disease • Experience with RNAseq or proteomics preferred • Strong English written and oral communication skills

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Position: Research Technician

Research Area: Neuroinflammatory Diseases

Full/Part Time: Full Time

Investigator: Chen, John

Date Posted: 2021-08-03

Description: We are looking for an enthusiastic and bright research technician to join a translational imaging laboratory to conduct research in neuroinflammatory diseases at the Massachusetts General Hospital. Our laboratory works on novel diagnostic and therapeutic agents to track and treat against inflammation in a variety of CNS disorders in preclinical models and seek to apply the findings in clinical settings. Our work had been published in Science, PNAS, Brain, JCI, and Radiology. Successful candidate should be inquisitive and have a strong desire to learn, as well as work well in a team-oriented environment. Dr. Chen’s laboratory is affiliated with the Center for Systems Biology (https://csb.mgh.harvard.edu), a major thematic center at MGH, and the Institute for Innovation in Imaging (https://i3.mgh.harvard.edu), a center focused on enabling translation of novel diagnostic technologies at MGH, the latter of which Dr. Chen also co-directs. In addition to a strong funding record, Dr. Chen has a strong mentoring record, including being the primary mentor for multiple NIH K-awards awarded to his former fellows as well as helping his trainees get into graduate and medical schools. The assistant will have an excellent environment to not only perform state-of-the-art research but also opportunities to learn from and interact with world-renowned scientists at both centers, as well as MGH and the greater Harvard community.

Requirements: • Bachelor’s or Master’s degree in a science or engineering field. • Strong English written and oral communication skills

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Position: Research Scientist

Research Area: Immuno-oncology and head and neck cancer

Full/Part Time: Full Time

Investigator: Pai, Sara

Date Posted: 2021-08-03

Description: The Pai Lab in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School invites applications for a Research Scientist position. One position is available.

Responsibilities: The Senior Research Scientist is a highly skilled scientific professional who can independently develop and execute laboratory research studies to support the laboratory’s research endeavors in head and neck immuno-oncology. The person should be proficient in handling and processing human tissue and/or blood. The person is encouraged to write their own grants to launch their independent research.

Requirements: A PhD and/or MD required in Immunology, Biochemistry, Molecular Biology, or a related field. Three or more years of post-graduate work experience in a laboratory research, preferably within a large, academic setting. Must have proficiency in laboratory methods of molecular biology and/or immunology, and experience with LSRII, Cytof, or single cell RNASeq preferred. Animal skills for treatment, tumor measurement and imaging required. This is a 2-year position with the possibility of an extension.

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Position: Assistant Professor of Pathology

Research Area: Pathology

Full/Part Time: Full Time

Platform: Faculty

Date Posted: 2021-05-25

Description: The Center for Systems Biology (CSB)and Department of Pathology at the Massachusetts General Hospital (MGH) Research Institute and Harvard Medical School (HMS), in Boston are seeking an outstanding scientist for a faculty position. The Department of Pathology (Chair: David Louis) is one of the premier Pathology departments in the US and has a vibrant research program. The CSB (Director: Ralph Weissleder) is one of the five interdisciplinary thematic Centers at the MGH and is located in the Simches Research Building on the MGH campus.

Responsibilities: The search is for candidate(s) to be hired at the Instructor or Assistant Professor level at HMS.  Applicants should have a Ph.D. and/or M.D. or equivalent degree. Competitive candidates have an exceptional track record in basic or translational research, a history of independent funding and the potential to develop an outstanding, visionary and independent research program that supports the ultimate goal of multiplexed tissue analysis to prevent and cure human diseases.

Requirements: Areas of interest include computational pathology and machine learning with a strong focus on analysis and modeling of cellular and molecular-scale measurements of single cells in tissue, including highly multiplexed protein measurements, single cell genetic studies, imaging mass cytometry, 3D imaging at single cell resolution, as well as mathematical and engineering approaches directed toward understanding of tissue organization and disease progression. Our goals are to decipher how human biology functions in health and disease, and to apply newly learned knowledge to develop new diagnostics, biomarkers and therapies.   The applicant should have a strong research plan, which should synergize with ongoing basic, applied and translational research efforts at CSB and Pathology at MGH Research Institute. The successful candidates will be expected to build and maintain an internationally recognized, extramurally funded research program. The candidate should enjoy working collaboratively with other scientists.

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Position: T32 Postdoctoral fellow

Research Area: Cancer research through innovative systems approaches

Full/Part Time: Full Time

Group: Training Faculty

Date Posted: 2021-05-13

Description: With our current faculty of 34 mentors, enhanced facilities, scope of supported research and past accomplishments, we offer an outstanding research environment for the next generation of clinicians and scientists to be trained in molecular imaging and systems analysis.

Requirements: These positions are restricted to US citizens and/or permanent residents.

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Position: Postdoctoral Research Fellow

Research Area: Synthetic chemistry

Full/Part Time: Full Time

Investigator: Weissleder, Ralph

Date Posted: 2021-05-11

Description: The Weissleder lab in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School invites applications for Postdoctoral Research Fellow positions. One position is available in chemical synthesis of small molecules and bioconjugation. The Center has a diverse faculty with backgrounds in chemistry, biology, physics, engineering and medicine, and offers a lively and supportive environment in which to perform interdisciplinary science.

Responsibilities: We seek creative thinkers who take risks in defining and addressing important problems, and who use quantitative experimental, computational and/or theoretical approaches in their work.

Requirements: A Ph.D., M.D./Ph.D. or M.D. and permanent residency is required. The ideal candidate has an extensive synthetic background and track record in chemical syntheses and analyses. To apply, please send your CV, a summary of your most significant research accomplishments (300 words) and the email addresses of three references to: Serena Sullivan (Sullivan.Serena@mgh.harvard.edu), CSB, Simches Research Center, 185 Cambridge Street, Suite 5.210, Boston, MA 02114.

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Send your application to (please specify position): Serena Sullivan (Sullivan.Serena@mgh.harvard.edu), CSB, Simches Research Center, 185 Cambridge Street, Suite 5.210, Boston, MA 02114