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Investigator / Platform Research Area Position
Breton, Sylvie Physiology of the urogenital tract Research Technician
Naxerova, Kamila Investigating metastasis patterns in colorectal cancer and melanoma Postdoctoral Research Fellow
Weissleder, Ralph Molecular profiling of cancer cells and microscopy Postdoctoral Research Fellow
Babitt, Jodie Iron biology, molecular and cellular biology, animal models, genetics, biochemistry Postdoctoral Research Fellow
Weissleder, Ralph Cell Biology Postdoctoral Research Fellow
Weissleder, Ralph Synthetic chemistry Postdoctoral Research Fellow
Miller, Miles Multiscale Network Biology Postdoctoral Research Fellow
Higgins, John Mechanistic Mathematical Modeling of Human Disease Processes with Clinical Data Postdoctoral Research Fellow
More information:

Position: Research Technician

Research Area: Physiology of the urogenital tract

Full/Part Time: Full Time

Investigator: Breton, Sylvie

Date Posted: 2018-03-30

Description: The Center for Systems Biology and Program in Membrane Biology at Massachusetts General Hospital and Harvard Medical School is currently accepting applications for an open Research Technician I position. This position is funded by NIH grants that are investigating the physiology and pathophysiology of the urogenital tract, including the epididymis and the kidney.

Responsibilities: The candidate will be responsible for the maintenance and breeding of transgenic mouse colonies and for the genotyping of the pups generated. This work will also involve basic molecular biology and biochemical biology techniques including RT-PCR, Western blotting, co-immunoprecipitation, antibody purification, animal surgery, tissue preparation for immunofluorescence using conventional and laser scanning confocal microscopy. The candidate will also have general responsibilities including record keeping and ordering supplies.

Requirements: The candidate must have excellent laboratory skills, expertise with in vivo animal experimentation, molecular biology tools, and microscopy. Ideally, the candidate also has an interest in immunology, reproductive and renal biology, and bioimaging. Candidates will be working in a dynamic, multidisciplinary research environment and must therefore have excellent English written and oral communication skills, as well as capacity for teamwork. Start date: Spring 2018. Interested candidates should include an updated CV, complete contact information for two references, and a cover letter describing their past experience. Minimum of a Bachelor’s degree plus the equivalent of one year of directly related experience is required.


Position: Postdoctoral Research Fellow

Research Area: Investigating metastasis patterns in colorectal cancer and melanoma

Full/Part Time: Full Time

Investigator: Naxerova, Kamila

Date Posted: 2018-03-22

Description: Two postdoctoral positions in experimental and computational biology are available in the Naxerova laboratory at the Center for Systems Biology at Massachusetts General Hospital and Harvard Medical School. The Naxerova lab studies the evolutionary history of cancer, using a blend of high-throughput experimental and computational approaches. We are interested in understanding how processes of mutation and selection in normal (stem) cells set the stage for cancer evolution. Once a tumor develops, how does tissue-specific selection shape the cancer genome? How can we take advantage of genetic intra-tumor heterogeneity to gain insights into the life history of a cancer? A particular interest of the lab is metastasis evolution. Do metastases arise from distinct clones with special, genetically encoded properties or do they represent random samples of the primary tumor? Do all metastases arise independently from the primary tumor, or do they give rise to each other? Does metastatic spread happen early or late in tumor development? Perhaps most importantly, is there a correlation between the evolutionary history of metastases and clinical outcomes? These questions are difficult to study in humans because it is challenging to reconstruct occult events that happened years before diagnosis. We are developing and applying new methods for lineage tracing in human cancer, with the ultimate goal of understanding a tumor’s entire evolution from the founder cell to lethal systemic disease.

Responsibilities: We are looking for two postdoctoral fellows or PhD students to join the team. Both experimentally and computationally inclined candidates are encouraged to apply. We are implementing experimental methods that generate large amounts of complex data and can thus offer fertile playing grounds to both experimentalists and bioinformaticians.

Requirements: There are no specific requirements for the job – we can teach you all the specifics here – but you should really burn for cancer genetics, enjoy grappling with difficult problems, be friendly and collegial, and have a track record in academic science that shows your commitment to this line of work. To apply, please send a brief (less than 1 page) statement describing your interest in cancer (phylo-) genetics and your CV to Serena Sullivan (Sullivan.Serena@mgh.harvard.edu), CSB, Simches Research Center, 185 Cambridge Street, Suite 5.210, Boston, MA 02114.


Position: Postdoctoral Research Fellow

Research Area: Molecular profiling of cancer cells and microscopy

Full/Part Time: Full Time

Investigator: Weissleder, Ralph

Date Posted: 2017-10-11

Description: The labs of Ralph Weissleder and Hakho Lee in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School invite applications for Postdoctoral Research Fellow positions. One or two positions are available in molecular profiling of cancer cells (see Sci Transl Med. 2014;6(219):219ra9). The ideal candidate should have a background in microfluidics, optics (microscopy), protein/DNA diagnostics, and cell biology, with expertise in system implementation and benchwork. The Center (csb.mgh.harvard.edu) has a diverse faculty with backgrounds in engineering, chemistry, biology, physics, and medicine, and offers a lively and supportive environment in which to perform interdisciplinary science.

Responsibilities: We seek creative thinkers who take risks in defining and addressing important problems, and who use quantitative experimental, computational and/or theoretical approaches in their work. Research fellows are encouraged to write their own grants, following the training period, to launch their independent research.

Requirements: A Ph.D., M.D./Ph.D. or M.D. and permanent residency is required. To apply, please send your CV, a summary of your most significant research accomplishments (300 words) and the email addresses of three references to: Serena Sullivan (Sullivan.Serena@mgh.harvard.edu), CSB, Simches Research Center, 185 Cambridge Street, Suite 5.210, Boston, MA 02114.


Position: Postdoctoral Research Fellow

Research Area: Iron biology, molecular and cellular biology, animal models, genetics, biochemistry

Full/Part Time: Full Time

Investigator: Babitt, Jodie

Date Posted: 2017-10-11

Description: A Postdoctoral Fellow is sought to work in the Program in Membrane Biology/Division of Nephrology/Center for Systems Biology at the Massachusetts General Hospital. The goal of our research program is to understand the molecular and cellular mechanisms involved in iron homeostasis and to develop new therapeutic strategies to treat iron disorders such as anemia of chronic disease, thalassemia, and hemochromatosis. We employ a multidisciplinary approach including molecular and cell biology, biochemistry, and animal models.

Requirements: Candidates for this position must have an M.D. or Ph.D (or equivalent) in the biomedical sciences. Successful applicants will have an experimental background in molecular and cellular biology, biochemistry, and animal studies, a strong publication record, and excellent communication/interpersonal skills. Please email a cover letter, CV, and the names and contact information of three references to Babitt.jodie@mgh.harvard.edu.


Position: Postdoctoral Research Fellow

Research Area: Cell Biology

Full/Part Time: Full Time

Investigator: Weissleder, Ralph

Date Posted: 2017-10-11

Description: The Weissleder lab in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School invites applications for Postdoctoral Research Fellow positions. One position is available in molecular profiling of cancer cells (see Sci Transl Med. 2014;6(219):219ra9). The Center has a diverse faculty with backgrounds in chemistry, biology, physics, engineering and medicine, and offers a lively and supportive environment in which to perform interdisciplinary science.

Responsibilities: We seek creative thinkers who take risks in defining and addressing important problems, and who use quantitative experimental, computational and/or theoretical approaches in their work.

Requirements: A Ph.D., M.D./Ph.D. or M.D. and permanent residency is required. The ideal candidate has a background in protein/DNA diagnostics, cell biology, or molecular biology and has performed extensive benchwork in the past. To apply, please send your CV, a summary of your most significant research accomplishments (300 words) and the email addresses of three references to: Serena Sullivan (Sullivan.Serena@mgh.harvard.edu), CSB, Simches Research Center, 185 Cambridge Street, Suite 5.210, Boston, MA 02114.


Position: Postdoctoral Research Fellow

Research Area: Synthetic chemistry

Full/Part Time: Full Time

Investigator: Weissleder, Ralph

Date Posted: 2017-10-11

Description: The Weissleder lab in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School invites applications for Postdoctoral Research Fellow positions. One position is available in chemical synthesis of small molecules and bioconjugation. The Center has a diverse faculty with backgrounds in chemistry, biology, physics, engineering and medicine, and offers a lively and supportive environment in which to perform interdisciplinary science.

Responsibilities: We seek creative thinkers who take risks in defining and addressing important problems, and who use quantitative experimental, computational and/or theoretical approaches in their work.

Requirements: A Ph.D., M.D./Ph.D. or M.D. and permanent residency is required. The ideal candidate has an extensive synthetic background and track record in chemical syntheses and analyses. To apply, please send your CV, a summary of your most significant research accomplishments (300 words) and the email addresses of three references to: Serena Sullivan (Sullivan.Serena@mgh.harvard.edu), CSB, Simches Research Center, 185 Cambridge Street, Suite 5.210, Boston, MA 02114.


Position: Postdoctoral Research Fellow

Research Area: Multiscale Network Biology

Full/Part Time: Full Time

Investigator: Miller, Miles

Date Posted: 2017-10-11

Description: The Center for Systems Biology (csb.mgh.harvard.edu) has an immediate opening for a position within the Multiscale Network Biology Program, https://csb.mgh.harvard.edu/miller. The Center for Systems Biology is located within the Simches Research building on the main MGH campus, and features a dynamic, multi-disciplinary environment with close interactions with MGH clinician-researchers and investigators across Harvard and MIT. We offer excellent training opportunities in a young, dynamic and highly collaborative research environment including chemistry, chemical biology, molecular biology, systems biology, imaging and cancer research. All interested applicants should submit a CV and two letters of reference to Serena Sullivan (sullivan.serena@mgh.harvard.edu). 

Responsibilities: The candidate will be trained in advanced network analysis and image processing techniques including in vivo microscopy, image segmentation and morphometry, systems pharmacology, and multivariate analysis of large datasets.

Requirements: PhD is preferred but we will consider candidates with a MS and experience. A strong background in computational modeling and excellent command of spoken and written English are essential. Prior experience in cancer cell biology is a plus.


Position: Postdoctoral Research Fellow

Research Area: Mechanistic Mathematical Modeling of Human Disease Processes with Clinical Data

Full/Part Time: Full Time

Investigator: Higgins, John

Date Posted: 2017-10-11

Description: A post-doctoral position is available in the laboratory of John Higgins, MD, jointly located at the Harvard Medical School Department of Systems Biology and the Massachusetts General Hospital Center for Systems Biology and Department of Pathology.

Requirements: Qualified applicants will have extensive knowledge of and interest in human pathophysiology, dynamical systems, numerical methods, and good software engineering practices. For example, strong candidates would be able to compare and contrast the following: hemostasis and thrombosis, ODE and PDE, lymphocyte and myelocyte, quicksort and bubble sort. Applicants should have a Ph.D. and/or M.D. degree or be in their final year of their doctoral studies, and at least a strong undergraduate background in math, computer science, and engineering. Interested individuals should include an updated CV, complete contact information for three references, and a cover letter describing past research experience, career goals, and future research interests.


Send your application to (please specify position): Serena Sullivan (Sullivan.Serena@mgh.harvard.edu), CSB, Simches Research Center, 185 Cambridge Street, Suite 5.210, Boston, MA 02114

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability status, protected veteran status, or any other characteristics protected by law.