Bioconjugate Chemistry, Cancer Nanomedicine

The Miller Laboratory at the Massachusetts General Hospital Center for Systems Biology is recruiting a full-time Postdoctoral Research Fellow.

The Miller Laboratory for Precision Therapeutics develops new chemical and nanotechnology-based approaches for spatially controlled cancer therapy. Our research combines organic synthesis, bioconjugate chemistry, drug delivery, molecular imaging, cancer biology, immunology, and quantitative tissue analysis to understand and engineer how therapeutics behave within tumors.

Representative Research:
Kang M, Quintana JM, Hu H, et al. Sustained and Localized Drug Depot Release Using Radiation-Activated Scintillating Nanoparticles. Advanced Materials. 2024;36(23).
Rodriguez-Castellanos VE, Quintana JM, Martin JM, et al. Radiation-Triggered Payload Release Enhances Bispecific Antibody Efficacy. Cancer Research. 2026;86(2):453–466.
Quintana JM, Jiang F, Kang M, et al. Localized In Vivo Prodrug Activation Using Radionuclides. Journal of Nuclear Medicine. 2025;66(1):91–97.
Di Ianni E, Jeon J, Mohammadi S, et al. Enhanced mRNA Delivery Using Ultrasound-Delivered Anchors for Bioorthogonal Ligation. Angewandte Chemie International Edition. 2026;65(10).

Additional information is available on the Miller Laboratory website: https://csb.mgh.harvard.edu/miller

To Apply:
Please email the following materials to Miles A. Miller, PhD, at miles.miller@mgh.harvard.edu:

A cover letter describing your research background, technical expertise, research interests, and interest in the position.

A current curriculum vitae.

Please use the email subject line:
Postdoctoral Application — Bioconjugate Chemistry and Nanomedicine

Applications will be reviewed on a rolling basis until the position is filled.

The successful candidate will lead projects involving radiation-activated chemistry, drug conjugates, and externally triggered therapeutic systems. Research may include the design and organic synthesis of radiation-responsive linkers and prodrugs; development of antibody, protein, polymer, or nanoparticle conjugates; investigation of radiation-mediated payload activation; and characterization of new compounds using HPLC, LC–MS, NMR spectroscopy, and related analytical methods.
Projects may also incorporate radiopharmaceuticals, ultrasound-responsive drug delivery, bioorthogonal chemistry, molecular imaging, and studies of the tumor immune microenvironment. Therapeutic distribution and response may be evaluated using preclinical tumor models, multiplex tissue imaging, flow cytometry, single-cell analysis, and spatial-omics techniques.
The fellow will work within a multidisciplinary environment and collaborate with chemists, cancer biologists, immunologists, engineers, imaging scientists, radiation oncologists, and other physician-scientists across Massachusetts General Hospital and the broader Harvard research community.

PhD or equivalent doctoral degree in organic chemistry, chemical biology, biological chemistry, medicinal chemistry, materials chemistry, bioengineering, or a related discipline.
Strong hands-on experience in organic synthesis and/or bioconjugate chemistry.
Experience in at least one additional relevant area, such as nanoparticle formulation, polymer chemistry, medicinal chemistry, biomaterials, or drug delivery.
Ability to work effectively both independently and as part of a multidisciplinary research team.
Candidates who expect to complete their doctoral degree before the anticipated start date are encouraged to apply.
Preferred but Not Required Qualifications
Experience in one or more of the following areas is beneficial:
Antibody–drug, protein–drug, or polymer–drug conjugates.
Stimuli-responsive or activatable chemistry.
Nanoparticle formulation and physicochemical characterization.
Radiochemistry and radiopharmaceuticals.
Cancer biology, tumor models, or cancer immunology.
Molecular imaging and microscopy.
Ultrasound-responsive materials or drug-delivery systems.
Pharmacology, pharmacokinetics, or biodistribution.
Flow cytometry, multiplex tissue imaging, single-cell sequencing, or spatial omics.

Applicants are not expected to have experience in all of these areas. Candidates with strong chemistry backgrounds who are interested in expanding into cancer biology, imaging, immunology, and translational therapeutics are particularly encouraged to apply.

Engineering, Extracellular vesicles, Diagnostic technologies

The Im Lab in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School, seeks highly motivated postdoctoral research scholars to develop next-generation diagnostic technologies for clinical translation. The candidate will work in a highly collaborative laboratory with several postdoctoral members from diverse backgrounds in engineering, computer science, biology, chemistry, and medicine. The laboratory provides a supportive research environment, working with clinicians in the hospital and industry partners.

An ideal candidate has expertise in one or more of the following areas: Engineering, Optics (microscopy), Microfluidics, Organ-on-a-chip, Extracellular Vesicles, Biology, Chemistry, Cell Biology, Computer Science, or other relevant fields.

We seek motivated and creative individuals with a Ph.D. or M.D./Ph.D. degree. To apply, please send your CV, a summary of your most significant research accomplishments, and the email addresses of two references to: Hyungsoon Im (im.hyungsoon@mgh.harvard.edu).

Cancer research through innovative systems approaches

With our current faculty of 34 mentors, enhanced facilities, scope of supported research and past accomplishments, we offer an outstanding research environment for the next generation of clinicians and scientists to be trained in molecular imaging and systems analysis.

These positions are restricted to US citizens and/or permanent residents.