Position: Postdoctoral Research Fellow

Research Area: Mechanistic Mathematical Modeling of Human Disease Processes with Clinical Data

Full/Part Time: Full Time

Investigator: Higgins, John

Date Posted: 2023-03-13

Description: A post-doctoral research position is available in the laboratory of John Higgins, MD, located in the Massachusetts General Hospital Center for Systems Biology and Department of Pathology and the Harvard Medical School Department of Systems Biology. Interested individuals should provide a CV and a cover letter describing past research experience, future research interests, career goals, and contact information for three references. Contact: John Higgins (john_higgins@hms.harvard.edu, https://sysbio.med.harvard.edu/john-higgins)

Requirements: Qualified applicants will have extensive knowledge of and interest in human pathophysiology and mathematical modeling including dynamical systems, statistical analysis, computational methods, and good software engineering practices. For example, strong candidates would be able to compare and contrast the following: hemostasis and thrombosis, ODE and PDE, lymphocyte and myelocyte, linear regression and conditional expectation. Applicants should have a Ph.D. and/or M.D. degree or be in their final year of their doctoral studies and at least a strong undergraduate background in math, computer science, or engineering.

Position: Research Technician

Research Area: Cancer Genetics and Tumor Evolution

Full/Part Time: Full Time

Investigator: Naxerova, Kamila

Date Posted: 2023-02-10

Description: A research technician position at the Naxerova laboratory at the Center for Systems Biology at Massachusetts General Hospital is available! The Naxerova lab studies the evolutionary history of cancer, using a blend of high-throughput experimental and computational approaches. We are interested in understanding how processes of mutation and selection in normal (stem) cells set the stage for cancer evolution. Once a tumor develops, how does tissue-specific selection shape the cancer genome? How can we take advantage of genetic intra-tumor heterogeneity to gain insights into the life history of a cancer? A particular interest of the lab is metastasis evolution. Do metastases arise from distinct clones with special, genetically encoded properties or do they represent random samples of the primary tumor? Do all metastases arise independently from the primary tumor, or do they give rise to each other? Does metastatic spread happen early or late in tumor development? Perhaps most importantly, is there a correlation between the evolutionary history of metastases and clinical outcomes? These questions are difficult to study in humans because it is challenging to reconstruct occult events that happened years before diagnosis. We are developing and applying new methods for lineage tracing in human cancer, with the ultimate goal of understanding a tumor’s entire evolution from the founder cell to lethal systemic disease. To apply, please send your CV to Kamila Naxerova (naxerova.kamila@mgh.harvard.edu). Please also check out the lab website csb.mgh.harvard.edu/naxerova for more information about publications and current lab members.

Responsibilities: We are looking for a motivated research technician to participate in projects investigating metastasis patterns in colorectal cancer and melanoma. Apart from getting a solid theoretical foundation in cancer genetics, you will learn how to evaluate human tumor samples histologically and how to collect tissue material and isolate DNA from it. You will also be analyzing complex data in R and Python. Thus, you will be exposed to a variety of experimental and bioinformatic methods, which will be useful if you want to apply to graduate or medical school at a later point in time. Our team is very collaborative and friendly.

Requirements: The candidate should have a Bachelor’s degree and lab experience.

Position: Postdoctoral Research Fellow

Research Area: Cancer Biology

Full/Part Time: Full Time

Investigator: Weissleder, Ralph

Date Posted: 2023-02-06

Description: The Center for Systems Biology (CSB) at Massachusetts General Hospital (MGH) seeks applications for a T32 postdoctoral fellows interested in cancer biology. We seek outstanding individuals with PhD, MD, or MD-PhD degrees who are US residents. Areas of interest include spatial proteomics, single cell analysis, exosomes, immunology, chemistry, imaging, as well as mathematical and engineering approaches directed toward understanding of tissue organization and disease progression.

Requirements: Interested candidates are invited to submit application materials. Each application must include one PDF file with: i) a cover letter indicating research plan including a statement of impact, ii) a curriculum vitae and iii) three references.

Position: Research Scientist

Research Area: Immuno-oncology and head and neck cancer

Full/Part Time: Full Time

Investigator: Pai, Sara

Date Posted: 2022-11-17

Description: The Pai Lab in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School invites applications for a Research Scientist position. One position is available.

Responsibilities: The Senior Research Scientist is a highly skilled scientific professional who can independently develop and execute laboratory research studies to support the laboratory’s research endeavors in head and neck immuno-oncology.

Requirements: A PhD and/or MD required in Immunology, Biochemistry, Molecular Biology, or a related field. Three or more years of post-graduate work experience in a laboratory research, preferably within a large, academic setting. Must have proficiency in laboratory methods of molecular biology and/or immunology, and experience with multi-color flow cytometry. Animal skills for treatment, tumor measurement and imaging required. This is a 2-year position with the possibility of an extension based on performance and skill.

Position: Postdoctoral Research Fellow

Research Area: Single cell profiling of the tumor microenvironment

Full/Part Time: Full Time

Investigator: Weissleder, Ralph

Date Posted: 2022-10-17

Description: The lab of Ralph Weissleder in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School has a number of openings for Postdoctoral Research Fellows. The ideal candidate should have a background in microscopy, cell culture and immunology with expertise in system implementation and benchwork. The Center (csb.mgh.harvard.edu) has a diverse faculty with backgrounds in engineering, chemistry, biology, physics, and medicine, and offers a lively and supportive environment in which to perform interdisciplinary science.

Responsibilities: We seek creative thinkers who take risks in defining and addressing important problems, and who use quantitative experimental, computational and/or theoretical approaches in their work. Research fellows are encouraged to write their own grants, following the training period, to launch their independent research.

Requirements: A Ph.D., M.D./Ph.D. or M.D. and permanent residency is required. To apply, please send your CV, a summary of your most significant research accomplishments (300 words) and the email addresses of three references to: Serena Sullivan (Sullivan.Serena@mgh.harvard.edu), CSB, Simches Research Center, 185 Cambridge Street, Suite 5.210, Boston, MA 02114.

Position: Postdoctoral Research Fellow

Research Area: Synthetic chemistry

Full/Part Time: Full Time

Investigator: Weissleder, Ralph

Date Posted: 2022-10-17

Description: The Weissleder lab in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School invites applications for Postdoctoral Research Fellow positions. One position is available in chemical synthesis of small molecules and bioconjugation. The Center has a diverse faculty with backgrounds in chemistry, biology, physics, engineering and medicine, and offers a lively and supportive environment in which to perform interdisciplinary science.

Responsibilities: We seek creative thinkers who take risks in defining and addressing important problems, and who use quantitative experimental, computational and/or theoretical approaches in their work.

Requirements: A Ph.D., M.D./Ph.D. or M.D. and permanent residency is required. The ideal candidate has an extensive synthetic background and track record in chemical syntheses and analyses. To apply, please send your CV, a summary of your most significant research accomplishments (300 words) and the email addresses of three references to: Serena Sullivan (Sullivan.Serena@mgh.harvard.edu), CSB, Simches Research Center, 185 Cambridge Street, Suite 5.210, Boston, MA 02114.

Position: Postdoctoral Research Fellow

Research Area: Exosome analysis

Full/Part Time: Full Time

Investigator: Weissleder, Ralph

Date Posted: 2022-10-17

Description: The lab of Ralph Weissleder (https://csb.mgh.harvard.edu/weissleder) in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School invites applications for Postdoctoral Research Fellow positions. A position is available in single cell and exosome analysis. Ideal candidates should have a strong academic background, US training and prior publications. The Center has a diverse faculty and offers a lively and supportive environment in which to perform interdisciplinary science.

Responsibilities: We seek creative thinkers who take risks in defining and addressing important problems, and who use quantitative experimental, computational and/or theoretical approaches in their work. Research fellows are encouraged to write their own grants, following the training period, to launch their independent research.

Requirements: A Ph.D., or M.D./Ph.D. and permanent residency is required. To apply, please send your CV, a summary of your most significant research accomplishments (300 words) and the email addresses of three references to: Serena Sullivan Sullivan.Serena@mgh.harvard.edu.

Position: Postdoctoral Research Fellow

Research Area: Computational cell analysis

Full/Part Time: Full Time

Investigator: Weissleder, Ralph

Date Posted: 2022-10-17

Description: The lab of Ralph Weissleder (https://csb.mgh.harvard.edu/weissleder) in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School invites applications for Postdoctoral Research Fellow positions. One position is available in computational single cell analysis, spatial profiling, temporal profiling and modeling. Ideal candidates should have a strong academic background, US training and prior publications. The Center has a diverse faculty and offers a lively and supportive environment in which to perform interdisciplinary science.

Responsibilities: We seek creative thinkers who take risks in defining and addressing important problems, and who use quantitative experimental, computational and/or theoretical approaches in their work. Research fellows are encouraged to write their own grants, following the training period, to launch their independent research.

Requirements: A Ph.D., or M.D./Ph.D. and permanent residency is required. To apply, please send your CV, a summary of your most significant research accomplishments (300 words) and the email addresses of three references to: Serena Sullivan Sullivan.Serena@mgh.harvard.edu.

Position: T32 Postdoctoral fellow

Research Area: Cancer research through innovative systems approaches

Full/Part Time: Full Time

Group: Training Faculty

Date Posted: 2022-10-17

Description: With our current faculty of 34 mentors, enhanced facilities, scope of supported research and past accomplishments, we offer an outstanding research environment for the next generation of clinicians and scientists to be trained in molecular imaging and systems analysis.

Requirements: These positions are restricted to US citizens and/or permanent residents.

Position: Research Technician

Research Area: Translational Research in Head and Neck Cancer

Full/Part Time: Full Time

Investigator: Pai, Sara

Date Posted: 2022-10-17

Description: The Research Technician will fulfill a crucial role for the head and neck cancer research community and will support a large number of collaborative research projects. Responsibilities will include: collect and process human and murine blood and tissue samples, perform immunohistochemistry/immunofluorescence, assist with troubleshooting protocols , maintain a human tissue bank, maintain a database of clinical trial specimens, perform murine studies, and perform maintenance tasks that facilitate the daily functioning of the laboratory. The Research Technician I will interact with clinical and research staff and patients, collect research specimens from the clinics and operating rooms, process and store biological specimens, maintain records and databases, and support research efforts of the scientists in the laboratory.

Responsibilities: Primary responsibilities: • Consent patients to research protocols • Collect, record, process and store serum, plasma and leukocytes isolated from patient blood samples per standard operating protocols (SOP) • Collect tissue specimens from the operating room and clinic • Record, process and store tissue specimens per SOP • Isolate DNA and RNA from samples • Maintain records/databases • Perform immunohistochemistry and/or immunofluorescence staining • Perform basic staining for flow cytometry • Perform cell culture using sterile technique • Conduct murine work (intraperitoneal, intramuscular, and subcutaneous injections), surgical techniques such as xenografting and vaccinations Secondary responsibilities: • Prepare specimens, DNA, RNA, and cDNA for collaborators • Perform basic research techniques such as PCR, qPCR • Maintain and control lab equipment, including review of equipment calibration sheets. • Monitor inventory levels and proper storage of materials and supplies in accordance with established policies and procedures. • Attend weekly laboratory meetings • Work safely within the lab environment and in performing work duties. • Perform other duties as assigned.

Requirements: Work collaboratively as a member of a team. Able to perform laboratory experiments and utilize laboratory equipment independently. Attention to detail and has organizational skills. Must be able to work safely and properly use protective equipment. Excellent verbal and written communication skills. Knowledge of basic word processing. Is knowledgeable and compliant in all hospital, State and Federal regulatory requirements, including hospital policy and procedures (where applicable to the performance of the job), Joint Commission on Accreditation of Healthcare Organizations (JCAHO), and Health Insurance Portability and Accountability Act of 1996 (HIPAA). Bachelor's degree in biological or physical sciences. Experience as attained through education with work in an immunology laboratory preferred. A 2 year commitment is preferred.

Position: Research Technician

Research Area: Spatial and Systems Oncology

Full/Part Time: Full Time

Investigator: Hwang, William

Date Posted: 2022-10-11

Description: The Hwang Lab (Laboratory for Spatial and Systems Oncology) in the Center for Systems Biology, Center for Cancer Research, and Department of Radiation Oncology at Massachusetts General Hospital, Harvard Medical School (https://www.whwanglab.org/) is looking for an exceptional research technician who wants to work as an integral part of a fun, collegial team on solving big problems in spatial and systems oncology and with a principal investigator who prioritizes mentorship. Prior technicians have been co-first authors and co-authors on 3 or more high impact papers each, presented as lead authors at conferences, and gained admission to prestigious MD and PhD programs such as the Harvard-MIT Health Sciences and Technology program. This training experience is ideal for preparing candidates who are interested in pursuing subsequent PhD and/or MD training. The research technician will have an opportunity to work closely with Dr. Hwang and team members to elucidate mechanisms of therapeutic resistance in cancer, develop translatable biomarkers to track tumor remodeling during treatment, and/or investigate the interface of cancer with the nervous system. You will have the opportunity to develop and apply techniques in single-cell and spatial biology, imaging, genetic screens, and neuroscience to patient tumors and cutting-edge model systems of cancer (e.g., organoids, mouse models). The Hwang Lab works broadly on gastrointestinal malignancies with a particular focus on pancreatic cancer. Ideal candidates should have a strong interest in cancer biology and/or neuroscience, prior experience in laboratory biological research, motivated and willing to learn new techniques, thrive in both collaborative and independent situations, and highly organized. A 2-year commitment is preferred and if the candidate is interested, they may have the opportunity to lead or co-lead an independent project during their tenure.

Responsibilities: The research technician will design and execute experimental protocols in support of the diverse research efforts in the laboratory. Specific responsibilities and skills that will be developed through this role include but are not limited to leading edge spatial proteotranscriptomics, multiplexed confocal/immunofluorescence imaging, single-cell and -nucleus RNA-sequencing and multiomics, blood/plasma multiomics, advanced 2D and 3D cell culture techniques, molecular cloning/lentiviral transduction/CRISPR genetic engineering, mouse colony management, survival surgeries and orthotopic pancreatic transplants, dorsal root ganglion dissections and neuronal culture techniques, live cell imaging and neurite tracking, immunohistochemistry, Western blot, qPCR, drug screens, and flow cytometry. Prepares basic solutions and performs base-level procedures as assigned (i.e. – pipetting, cell and tissue culture, etc.) Maintains laboratory notebook Understands and applies basic scientific techniques Conducts analysis of results and may begin interpretation of results Sets up and prepares routine experiments as directed Prepares lab reagents, chemicals, instruments and equipment May perform independent literature searches Assists with organizing materials for publication or presentation A Research Technician II performs the duties of a Research Technician I (above) and may also: Execute protocols of non-routine experiments Assist the PI(s) with determining the most suitable methodology Perform basic design and modification of protocols Calculate, transcribe and analyze data Prepare and present reports Organize and summarize acquired data, using scientific and statistical techniques. Organize and/or draft material for the preparation of research papers, manuscripts and other documents for publication and/or presentation. Participate in the design of experiments or field work.

Requirements: A Bachelor’s degree is required before the anticipated start date, with prior laboratory experience in laboratory cancer biology and/or neuroscience preferred. This position is full time. To formally apply please go to, https://www.massgeneral.org/careers/apply and search for job ID# 3216413. In addition to this you may send your resume, short summary of prior academic/research experiences and career goals, and a list of personal/professional references to Serena Sullivan at sullivan.serena@mgh.harvard.edu and William Hwang, MD, PhD at whwang1@mgh.harvard.edu.