Investigator / Platform Research Area Position
Weissleder, Ralph Computational cell analysis Postdoctoral Research Fellow
Weissleder, Ralph Exosome analysis Postdoctoral Research Fellow
Weissleder, Ralph Synthetic chemistry Postdoctoral Research Fellow
Weissleder, Ralph Single cell profiling of the tumor microenvironment Postdoctoral Research Fellow
Pai, Sara Immuno-oncology and head and neck cancer Research Scientist
Naxerova, Kamila Cancer Genetics Research Technician I
Naxerova, Kamila Cancer genetics and tumor evolution Postdoctoral Research Fellow
Naxerova, Kamila Bioinformatics Research Technician II
Nahrendorf, Matthias Mouse Imaging Research Technician I
Lee, Hakho System engineering and development Postdoctoral Research Fellow
Im, Hyungsoon Engineering, Extracellular vesicles, Neuroscience Postdoctoral Research Fellow
Garris, Christopher Biology of dendritic cells in cancer growth and response to therapy Postdoctoral Research Fellow
Garris, Christopher Cancer Immunology and Dendritic Cell Biology Research Technician
Faculty Pathology Assistant Professor of Pathology
Training Faculty Cancer research through innovative systems approaches T32 Postdoctoral fellow
More information:

Position: Research Technician

Research Area: Cancer Immunology and Dendritic Cell Biology

Full/Part Time: Full Time

Investigator: Garris, Christopher

Date Posted: 2022-01-03

Description: The Garris Lab in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School (https://csb.mgh.harvard.edu/garris ) is looking for an exceptional research technician who desires a background in cancer immunology and dendritic cell biology. Ideal candidates should have a strong interest in immunology, some background in biological research, and be quick to learn. As a lab, we are interested in the factors that determine tumor recognition by the immune system. We study the dendritic cell, which gets the “ball rolling” on anti-tumor immune responses, and how these cells can be modulated to enhance anti-tumor immunity. If this sounds exciting to you, then you’re welcome to apply. The research technician will gain experience in academic research and is a good opportunity for candidates looking to advance to higher education. The research technician will also receive substantial hands on mentoring for research techniques and experimental design.

Responsibilities: The research technician will design and execute laboratory research in support of the lab’s mission to investigate immune mechanisms of tumor rejection. Tasks include mouse colony management, in vivo tumor growth studies, flow cytometry, cell tissue culture, imaging, and assay design. Creative thinkers who are willing to take risks and define important unmet problems in cancer research are encouraged to apply. Candidates will receive a high degree of hands on mentoring, and will be encouraged to seek higher education opportunities.

Requirements: This position has a 2 year minimum commitment. A B.S./B.A. is required, with experience in immunology or cancer biology preferred. This position is full time. To apply, please send your resume and a short summary of your prior research accomplishments and career goals to Christopher Garris at positions@garrislab.com

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Position: Postdoctoral Research Fellow

Research Area: Single cell profiling of the tumor microenvironment

Full/Part Time: Full Time

Investigator: Weissleder, Ralph

Date Posted: 2021-12-21

Description: The lab of Ralph Weissleder in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School has a number of openings for Postdoctoral Research Fellows. The ideal candidate should have a background in microscopy, cell culture and immunology with expertise in system implementation and benchwork. The Center (csb.mgh.harvard.edu) has a diverse faculty with backgrounds in engineering, chemistry, biology, physics, and medicine, and offers a lively and supportive environment in which to perform interdisciplinary science.

Responsibilities: We seek creative thinkers who take risks in defining and addressing important problems, and who use quantitative experimental, computational and/or theoretical approaches in their work. Research fellows are encouraged to write their own grants, following the training period, to launch their independent research.

Requirements: A Ph.D., M.D./Ph.D. or M.D. and permanent residency is required. To apply, please send your CV, a summary of your most significant research accomplishments (300 words) and the email addresses of three references to: Serena Sullivan (Sullivan.Serena@mgh.harvard.edu), CSB, Simches Research Center, 185 Cambridge Street, Suite 5.210, Boston, MA 02114.

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Position: Postdoctoral Research Fellow

Research Area: Synthetic chemistry

Full/Part Time: Full Time

Investigator: Weissleder, Ralph

Date Posted: 2021-12-21

Description: The Weissleder lab in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School invites applications for Postdoctoral Research Fellow positions. One position is available in chemical synthesis of small molecules and bioconjugation. The Center has a diverse faculty with backgrounds in chemistry, biology, physics, engineering and medicine, and offers a lively and supportive environment in which to perform interdisciplinary science.

Responsibilities: We seek creative thinkers who take risks in defining and addressing important problems, and who use quantitative experimental, computational and/or theoretical approaches in their work.

Requirements: A Ph.D., M.D./Ph.D. or M.D. and permanent residency is required. The ideal candidate has an extensive synthetic background and track record in chemical syntheses and analyses. To apply, please send your CV, a summary of your most significant research accomplishments (300 words) and the email addresses of three references to: Serena Sullivan (Sullivan.Serena@mgh.harvard.edu), CSB, Simches Research Center, 185 Cambridge Street, Suite 5.210, Boston, MA 02114.

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Position: Research Technician II

Research Area: Bioinformatics

Full/Part Time: Full Time

Investigator: Naxerova, Kamila

Date Posted: 2021-12-21

Description: A research technician or data analyst position is available in the Nahrendorf and Naxerova laboratories at the Center for Systems Biology at Massachusetts General Hospital and Harvard Medical School. If you are a motivated scientist with a Bachelor’s or Master’s degree in computational biology, bioinformatics, statistics or related relevant fields, and you want to be part of a dynamic, friendly team that produces and analyzes a large amount of complex data (bulk and single cell RNA sequencing data), please consider applying! We have a multitude of interesting projects in cardiovascular disease research that will provide a rich playing ground for a person who enjoys thinking about data and its (biological) implications. We are looking for somebody who will actively be engaged in the research and take responsibility for their projects. This is not a job in which you will be told what to do step by step. Please review these websites to learn more about our research: https://csb.mgh.harvard.edu/naxerova https://csb.mgh.harvard.edu/nahrendorf

Responsibilities: After a thorough training phase, you will work independently and be able to realize your own ideas. You will be embedded into a great research team with lots of support, both from the biological as well as from the bioinformatics side.

Requirements: Bachelor’s or Master’s degree in computational biology, bioinformatics, statistics or related relevant fields Recent graduates who are looking to earn a few years of research experience before applying to graduate school are particularly welcome.

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Position: Postdoctoral Research Fellow

Research Area: Cancer genetics and tumor evolution

Full/Part Time: Full Time

Investigator: Naxerova, Kamila

Date Posted: 2021-12-21

Description: Two postdoctoral positions in cancer genetics are available in the Naxerova laboratory at the Center for Systems Biology at Massachusetts General Hospital and Harvard Medical School. The Naxerova lab studies the evolutionary history of cancer, using a blend of high-throughput experimental and computational approaches. We are interested in understanding how processes of mutation and selection in normal (stem) cells set the stage for cancer evolution. Once a tumor develops, how does tissue-specific selection shape the cancer genome? How can we take advantage of genetic intra-tumor heterogeneity to gain insights into the life history of a cancer? A particular interest of the lab is metastasis evolution. Do metastases arise from distinct clones with special, genetically encoded properties or do they represent random samples of the primary tumor? Do all metastases arise independently from the primary tumor, or do they give rise to each other? Does metastatic spread happen early or late in tumor development? Perhaps most importantly, is there a correlation between the evolutionary history of metastases and clinical outcomes? These questions are difficult to study in humans because it is challenging to reconstruct occult events that happened years before diagnosis. We are developing and applying new methods for lineage tracing in human cancer, with the ultimate goal of understanding a tumor’s entire evolution from the founder cell to lethal systemic disease. We have exciting new projects in the works and are looking for two postdoctoral fellows to join the team. Both experimentally and computationally inclined candidates are encouraged to apply. We are implementing experimental methods that generate large amounts of complex data and can thus offer fertile playing grounds to both experimentalists and bioinformaticians. The ideal candidate should be interested in doing some amount of both. To apply, please send a brief (less than 1 page) statement describing your interest in cancer genetics and your CV to Kamila Naxerova (naxerova.kamila@mgh.harvard.edu). Please check out the lab website csb.mgh.harvard.edu/naxerova for more information about publications and current lab members. We are a friendly, motivated team that is looking forward to hearing from you! The Center for Systems Biology (CSB), a multidisciplinary thematic center at Massachusetts General Hospital and Harvard Medical School, houses a vibrant scientific community united by its interest in integrative, quantitative biology and translational medicine. CSB and the larger Harvard community in which it is embedded offer near limitless opportunities for education and interdisciplinary collaboration. MGH offers excellent benefits to all employees and is an equal opportunity employer.

Requirements: There are no specific requirements for the job – we can teach you all the specifics here – but you should really burn for cancer genetics, enjoy grappling with difficult problems, be friendly and collegial, and have a track record in academic science that shows your commitment to this line of work.

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Position: Postdoctoral Research Fellow

Research Area: Engineering, Extracellular vesicles, Neuroscience

Full/Part Time: Full Time

Investigator: Im, Hyungsoon

Date Posted: 2021-12-21

Description: The Im Lab in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School seeks highly motivated postdoctoral research scholars to develop next-generation diagnostic technologies for clinical translation. The candidate will work in a highly collaborative laboratory of several postdoc members with backgrounds in engineering, computer science, biology, chemistry, and medicine. The laboratory provides a supportive research environment working with clinicians in the hospital and industry partners.

Responsibilities: An ideal candidate has expertise in one or more of the following areas: Engineering, Optics (microscopy), Microfluidics, Organ-on-a-chip, Extracellular Vesicles, Biology, Chemistry, Neuroscience, Cell Biology, Computer Science, or relevant areas.

Requirements: We seek motivated and creative individuals with a Ph.D. or M.D./Ph.D. degree. To apply, please send your CV, a summary of your most significant research accomplishments, and the email addresses of two references to: Hyungsoon Im (im.hyungsoon@mgh.harvard.edu).

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Position: Postdoctoral Research Fellow

Research Area: System engineering and development

Full/Part Time: Full Time

Investigator: Lee, Hakho

Date Posted: 2021-12-21

Description: The Lee laboratory at Center for Systems Biology, Massachusetts General Hospital is recruiting a research fellow (PhD level) in the field described below. • Fields: Systems engineering (Experience in microscopy, plasmonics, biosensor and/or related projects is preferred). • Skill sets: System development (optical setup, electronics, and computer control), microscopy, circuit design and prototyping, bioassays (e.g., ELISA, microscopy)

Responsibilities: The candidate will work with other team members to lead the development of new diagnostic or imaging systems to analyze extracellular vesicles or other analytical targets.

Requirements: (i) Academic degree holders (including prospective graduation by Fall 2020). (ii) Good verbal and written communication skills in English. (iii) High impact publications from previous research period. (iv) Minimum commitment of two years.

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Position: Postdoctoral Research Fellow

Research Area: Exosome analysis

Full/Part Time: Full Time

Investigator: Weissleder, Ralph

Date Posted: 2021-12-21

Description: The lab of Ralph Weissleder (https://csb.mgh.harvard.edu/weissleder) in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School invites applications for Postdoctoral Research Fellow positions. A position is available in single cell and exosome analysis. Ideal candidates should have a strong academic background, US training and prior publications. The Center has a diverse faculty and offers a lively and supportive environment in which to perform interdisciplinary science.

Responsibilities: We seek creative thinkers who take risks in defining and addressing important problems, and who use quantitative experimental, computational and/or theoretical approaches in their work. Research fellows are encouraged to write their own grants, following the training period, to launch their independent research.

Requirements: A Ph.D., or M.D./Ph.D. and permanent residency is required. To apply, please send your CV, a summary of your most significant research accomplishments (300 words) and the email addresses of three references to: Serena Sullivan Sullivan.Serena@mgh.harvard.edu.

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Position: Postdoctoral Research Fellow

Research Area: Computational cell analysis

Full/Part Time: Full Time

Investigator: Weissleder, Ralph

Date Posted: 2021-12-21

Description: The lab of Ralph Weissleder (https://csb.mgh.harvard.edu/weissleder) in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School invites applications for Postdoctoral Research Fellow positions. One position is available in computational single cell analysis, spatial profiling, temporal profiling and modeling. Ideal candidates should have a strong academic background, US training and prior publications. The Center has a diverse faculty and offers a lively and supportive environment in which to perform interdisciplinary science.

Responsibilities: We seek creative thinkers who take risks in defining and addressing important problems, and who use quantitative experimental, computational and/or theoretical approaches in their work. Research fellows are encouraged to write their own grants, following the training period, to launch their independent research.

Requirements: A Ph.D., or M.D./Ph.D. and permanent residency is required. To apply, please send your CV, a summary of your most significant research accomplishments (300 words) and the email addresses of three references to: Serena Sullivan Sullivan.Serena@mgh.harvard.edu.

Apply

Position: Research Technician I

Research Area: Cancer Genetics

Full/Part Time: Full Time

Investigator: Naxerova, Kamila

Date Posted: 2021-12-21

Description: Are you hoping to become a scientist or physician one day? Do you want a challenging job in a fascinating environment that can prepare you for such a path? Are you interested in the genetics of cancer? Are you conscientious and detail-oriented, do you enjoy working in a team while solving difficult problems? If so, you should apply for this research technician position. The Naxerova lab studies the evolutionary history of cancer, using a blend of high-throughput experimental and computational approaches. We are interested in understanding how processes of mutation and selection in normal (stem) cells set the stage for cancer evolution. Once a tumor develops, how does tissue-specific selection shape the cancer genome? How can we take advantage of genetic intra-tumor heterogeneity to gain insights into the life history of a cancer? A particular interest of the lab is metastasis evolution. Do metastases arise from distinct clones with special, genetically encoded properties or do they represent random samples of the primary tumor? Do all metastases arise independently from the primary tumor, or do they give rise to each other? Does metastatic spread happen early or late in tumor development? Perhaps most importantly, is there a correlation between the evolutionary history of metastases and clinical outcomes? These questions are difficult to study in humans because it is challenging to reconstruct occult events that happened years before diagnosis. We are developing and applying new methods for lineage tracing in human cancer, with the ultimate goal of understanding a tumor’s entire evolution from the founder cell to lethal systemic disease.

Responsibilities: We are looking for a motivated research technician to participate in projects investigating metastasis patterns in colorectal cancer and melanoma. Apart from getting a solid theoretical foundation in cancer genetics, you will learn how to evaluate human tumor samples histologically and how to collect tissue material and isolate DNA from it. You will also be analyzing complex data in R and Python. Thus, you will be exposed to a variety of experimental and bioinformatic methods, which will be useful if you want to apply to graduate or medical school at a later point in time. Our team is very collaborative and friendly. Part of your time will be spent in the Center for Integrated Diagnostics (CID) where you will work with clinicians and participate in clinical workflows. The position really is a perfect mix of different challenges.

Requirements: Bachelor’s degree

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Position: T32 Postdoctoral fellow

Research Area: Cancer research through innovative systems approaches

Full/Part Time: Full Time

Group: Training Faculty

Date Posted: 2021-12-21

Description: With our current faculty of 34 mentors, enhanced facilities, scope of supported research and past accomplishments, we offer an outstanding research environment for the next generation of clinicians and scientists to be trained in molecular imaging and systems analysis.

Requirements: These positions are restricted to US citizens and/or permanent residents.

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Position: Research Scientist

Research Area: Immuno-oncology and head and neck cancer

Full/Part Time: Full Time

Investigator: Pai, Sara

Date Posted: 2021-12-21

Description: The Pai Lab in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School invites applications for a Research Scientist position. One position is available.

Responsibilities: The Senior Research Scientist is a highly skilled scientific professional who can independently develop and execute laboratory research studies to support the laboratory’s research endeavors in head and neck immuno-oncology. The person should be proficient in handling and processing human tissue and/or blood. The person is encouraged to write their own grants to launch their independent research.

Requirements: A PhD and/or MD required in Immunology, Biochemistry, Molecular Biology, or a related field. Three or more years of post-graduate work experience in a laboratory research, preferably within a large, academic setting. Must have proficiency in laboratory methods of molecular biology and/or immunology, and experience with LSRII, Cytof, or single cell RNASeq preferred. Animal skills for treatment, tumor measurement and imaging required. This is a 2-year position with the possibility of an extension.

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Position: Research Technician I

Research Area: Mouse Imaging

Full/Part Time: Full Time

Investigator: Nahrendorf, Matthias

Date Posted: 2021-12-21

Description: The Center for Systems Biology at the Massachusetts General Hospital is looking for a research assistant to conduct small animal imaging. The Center has a unique small animal imaging facility that includes two MRI’s (4.7T and 7T), a PET-CT, tomographic and planar optical imaging and confocal microcopy (https://csb.mgh.harvard.edu/mouse_imaging). The position provides the successful candidate with an opportunity to work in a vibrant molecular and physiological imaging core that serves a variety of research projects.

Responsibilities: We are interested in finding someone who has previous experience in mouse imaging, is motivated, independent, organized and dedicated to producing quality work. While prior imaging experience is a plus, the position would also be suitable for someone interested in exposure to research prior to medical or graduate school.

Requirements: A bachelors degree required. The position is full time, starting as soon as possible and would require at minimum two year commitment. If you are interested in this position, please send a copy of your CV and resume to Sullivan.Serena@mgh.harvard.edu.

Position: Postdoctoral Research Fellow

Research Area: Biology of dendritic cells in cancer growth and response to therapy

Full/Part Time: Full Time

Investigator: Garris, Christopher

Date Posted: 2021-12-21

Description: The Garris Lab in the Center for Systems Biology at the Massachusetts General Hospital, Harvard Medical School is looking for curious and driven postdoctoral research fellows who want to investigate the biology of dendritic cells in cancer growth and response to therapy. Ideal candidates should have a background in immunology research or cancer biology, with expertise in cell culture, flow cytometry, and in vivo mouse models.

Responsibilities: Postdoctoral fellows will design and execute laboratory research in support of the lab’s mission to investigate immune mechanisms of tumor rejection. Creative thinkers who are willing to take risks and define important unmet problems in cancer research are encouraged to apply. Candidates will receive a high degree of hands on mentoring, and will be encouraged to apply for their own grants with the eventual goal of the fellow launching their independent research career.

Requirements: A Ph.D., M.D., or M.D./Ph.D. is required, with experience in immunology or cancer biology. This position is full time. To apply, please send your CV, a short summary of your prior research accomplishments, and your list of career goals to Christopher Garris at positions@garrislab.com.

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Position: Assistant Professor of Pathology

Research Area: Pathology

Full/Part Time: Full Time

Platform: Faculty

Date Posted: 2021-05-25

Description: The Center for Systems Biology (CSB)and Department of Pathology at the Massachusetts General Hospital (MGH) Research Institute and Harvard Medical School (HMS), in Boston are seeking an outstanding scientist for a faculty position. The Department of Pathology (Chair: David Louis) is one of the premier Pathology departments in the US and has a vibrant research program. The CSB (Director: Ralph Weissleder) is one of the five interdisciplinary thematic Centers at the MGH and is located in the Simches Research Building on the MGH campus.

Responsibilities: The search is for candidate(s) to be hired at the Instructor or Assistant Professor level at HMS.  Applicants should have a Ph.D. and/or M.D. or equivalent degree. Competitive candidates have an exceptional track record in basic or translational research, a history of independent funding and the potential to develop an outstanding, visionary and independent research program that supports the ultimate goal of multiplexed tissue analysis to prevent and cure human diseases.

Requirements: Areas of interest include computational pathology and machine learning with a strong focus on analysis and modeling of cellular and molecular-scale measurements of single cells in tissue, including highly multiplexed protein measurements, single cell genetic studies, imaging mass cytometry, 3D imaging at single cell resolution, as well as mathematical and engineering approaches directed toward understanding of tissue organization and disease progression. Our goals are to decipher how human biology functions in health and disease, and to apply newly learned knowledge to develop new diagnostics, biomarkers and therapies.   The applicant should have a strong research plan, which should synergize with ongoing basic, applied and translational research efforts at CSB and Pathology at MGH Research Institute. The successful candidates will be expected to build and maintain an internationally recognized, extramurally funded research program. The candidate should enjoy working collaboratively with other scientists.

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Send your application to (please specify position): Serena Sullivan (Sullivan.Serena@mgh.harvard.edu), CSB, Simches Research Center, 185 Cambridge Street, Suite 5.210, Boston, MA 02114