Our lab conducts translational oncology research through early stage clinical studies inspired by nanotechnologies, systems biology, and biomarker driven therapies. We focus on solid tumors with an emphasis on highly lethal subtypes such as ovarian cancers. We subscribe to both “high-tech” and “low-tech” theranostic approaches that leverage innovative advances within CSB. To date, these efforts have generated traction both domestically and abroad. We are currently establishing a comprehensive multi-departmental program to prospectively profile gynecologic cancers including multi-omics (sequencing, proteomics, liquid biopsies), pathology (digital and multiplexed profiling), imaging and clinical phenotypes. We seek to ultimately advance cancer theranostics by better understanding the spatiotemporal evolution of cancers and uncovering novel treatment response readouts using integrated machine learning and statistical inferences. Our work has been externally funded by the National Cancer Institute, Robert Wood Johnson Foundation, V Foundation for Cancer Research, Ovarian Cancer Research Fund, and the Department of Defense.
Chin LK, Li H, Choi JH, Iwamoto Y, Oh J, Min J, Beak SK, Yoo D, Castro CM, Lee D, Im H Hydrogel Stamping for Rapid, Multiplexed, Point-of-Care Immunostaining of Cells and Tissues. ACS Appl Mater Interfaces. 2022;14(24):27613-27622 - PMID: 35671240 - DOI: 10.1021/acsami.2c05071
Woo HK, Cho YK, Lee CY, Lee H, Castro CM, Lee H Characterization and modulation of surface charges to enhance extracellular vesicle isolation in plasma. Theranostics. 2022;12(5):1988-1998 - PMID: 35265194 - PMCID: PMC8899565 - DOI: 10.7150/thno.69094 - Cover
Min J, Allen M, Castro CM, Lee H, Weissleder R, Im H Computational Optics for Point-of-Care Breast Cancer Profiling. Methods Mol Biol. 2022;2393:153-162 - PMID: 34837178 - DOI: 10.1007/978-1-0716-1803-5_8
Yu H, Lee H, Cheong J, Woo SW, Oh J, Oh HK, Lee JH, Zheng H, Castro CM, Yoo YE, Kim MG, Cheon J, Weissleder R, Lee H A rapid assay provides on-site quantification of tetrahydrocannabinol in oral fluid. Sci Transl Med. 2021;13(616):eabe2352 - PMID: 34669441 - PMCID: PMC9126021 - DOI: 10.1126/scitranslmed.abe2352 - Cover
Park J, Park JS, Huang CH, Jo A, Cook K, Wang R, Lin HY, Van Deun J, Li H, Min J, Wang L, Yoon G, Carter BS, Balaj L, Choi GS, Castro CM, Weissleder R, Lee H An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma. Nat Biomed Eng. 2021;5(7):678-689 - PMID: 34183802 - PMCID: PMC8437135 - DOI: 10.1038/s41551-021-00752-7
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