Membrane Biology Overview
The MGH Program in Membrane Biology (PMB) within the Division of Nephrology brings together a diverse group of 40 faculty, fellows, technical, and administrative staff who collaborate in research related to the functional importance of cell membranes, membrane proteins, vesicle trafficking and signal transduction in physiologically important processes in epithelial and non-epithelial cells. The PMB is also affiliated with the MGH Center for Systems Biology. More information about this center can be found here.
PMB Microscopy Core Facility
The PMB houses an extensive Microscopy Core Facility that is an MGH-registered Core Facility, available on a fee-for-service basis. All aspects of microscopy from basic wide-field and fluorescence imaging, confocal imaging, live cell imaging and TIRF (total internal reflection microscopy), and electron microscopy are available. The official Core website provides more details regarding equipment, cost and contact information. To access the core, please contact the appropriate persons (Dennis Brown for general inquiries, Richard Bouley for light and confocal microscopy, and Diane Capen for EM work and sectioning).
Battistone MA, Mendelsohn AC, Spallanzani RG, Allegretti AS, Liberman RN, Sesma J, Kalim S, Wall SM, Bonventre JV, Lazarowski ER, Brown D, Breton S Pro-inflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice. J Clin Invest. 2020;:ePub - PMID: 32287042 - DOI: 10.1172/JCI134791
Wang CY, Xu Y, Traeger L, Dogan DY, Xiao X, Steinbicker AU, Babitt JL Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3. Blood. 2020;135(6):453-456 - PMID: 31800957 - PMCID: PMC7005366 - DOI: 10.1182/blood.2019002620
Xiao X, Dev S, Canali S, Bayer A, Xu Y, Agarwal A, Wang CY, Babitt JL Endothelial Bmp2 knockout exacerbates hemochromatosis in Hfe knockout mice but not Bmp6 knockout mice. Hepatology. 2019;:ePub - PMID: 31778583 - PMCID: PMC7253321 - DOI: 10.1002/hep.31048
Bouley R, Yui N, Terlouw A, Cheung PW, Brown D Chlorpromazine Induces Basolateral Aquaporin-2 Accumulation via F-Actin Depolymerization and Blockade of Endocytosis in Renal Epithelial Cells. Cells. 2020;9(4):ePub - PMID: 32340337 - PMCID: PMC7226349 - DOI: 10.3390/cells9041057
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