Membrane Biology Overview

The MGH Program in Membrane Biology (PMB) within the Division of Nephrology brings together a diverse group of 40 faculty, fellows, technical, and administrative staff who collaborate in research related to the functional importance of cell membranes, membrane proteins, vesicle trafficking and signal transduction in physiologically important processes in epithelial and non-epithelial cells. The PMB is also affiliated with the MGH Center for Systems Biology. More information about this center can be found here.

PMB Microscopy Core Facility

The PMB houses an extensive Microscopy Core Facility that is an MGH-registered Core Facility, available on a fee-for-service basis. All aspects of microscopy from basic wide-field and fluorescence imaging, confocal imaging, live cell imaging and TIRF (total internal reflection microscopy), and electron microscopy are available. The official Core website provides more details regarding equipment, cost and contact information. To access the core, please contact the appropriate persons (Dennis Brown for general inquiries, Richard Bouley for light and confocal microscopy, and Diane Capen for EM work and sectioning).

Recent Publications

  • Battistone MA, Mendelsohn AC, Spallanzani RG, Allegretti AS, Liberman RN, Sesma J, Kalim S, Wall SM, Bonventre JV, Lazarowski ER, Brown D, Breton S Pro-inflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice. J Clin Invest. 2020;130(7):3734-3749 - PMID: 32287042 - PMCID: PMC7324186 - DOI: 10.1172/JCI134791

  • Wang CY, Xu Y, Traeger L, Dogan DY, Xiao X, Steinbicker AU, Babitt JL Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3. Blood. 2020;135(6):453-456 - PMID: 31800957 - PMCID: PMC7005366 - DOI: 10.1182/blood.2019002620

  • Xiao X, Dev S, Canali S, Bayer A, Xu Y, Agarwal A, Wang CY, Babitt JL Endothelial Bmp2 knockout exacerbates hemochromatosis in Hfe knockout mice but not Bmp6 knockout mice. Hepatology. 2019;:ePub - PMID: 31778583 - PMCID: PMC7253321 - DOI: 10.1002/hep.31048

  • Castro MM, Kim B, Games PD, Hill E, Neves CA, Serrão JE, Breton S, Machado-Neves M Distribution pattern of ZO-1 and claudins in the epididymis of vampire bats. Tissue Barriers. 2020;:1779526 - PMID: 32552339 - DOI: 10.1080/21688370.2020.1779526

  • More publications ...

News

2018-08-31: Sylvie Breton has been named the inaugural incumbent of the Richard Moerschner Endowed MGH Research Institute Chair in Men’s Health. Congratulations, Sylvie!
2018-04-23: Jodie Babitt was inducted into the American Society of Clinical Investigation in a ceremony on April 21. Established in 1908, ASCI is one of the nation’s oldest and most respected medical honor societies, comprised of physician-scientists elected at age 50 or younger for their outstanding records of scholarly achievement in biomedical research.
2017-10-10: Dennis Brown, PhD has been elected as a member of Academia Europaea (The Academy of Europe). Academia Europaea is the only Europe-wide academy with individual membership from Council of Europe states and other nations across the world.
2017-04-20: Science features CSB research on macrophages in the heart - (pdf)
2016-02-11: Dennis Brown, PhD, Professor of Medicine and Director of the MGH Program in Membrane Biology, part of the Division of Nephrology and the Center for Systems Biology, was elected by a poll of its members as the new President Elect of the American Physiological Society (APS). Established in 1887, the American Physiological Society (APS) was the first U.S. society in the biomedical sciences field. The Society represents more than 11,000 members and publishes 14 peer-reviewed journals with a worldwide readership.