Membrane Biology

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Membrane Biology

Overview

The MGH Program in Membrane Biology (PMB) within the Division of Nephrology brings together a diverse group of 40 faculty, fellows, technical, and administrative staff who collaborate in research related to the functional importance of cell membranes, membrane proteins, vesicle trafficking and signal transduction in physiologically important processes in epithelial and non-epithelial cells. The PMB is also affiliated with the MGH Center for Systems Biology. More information about this center can be found here.

PMB Microscopy Core Facility

The PMB houses an extensive Microscopy Core Facility that is an MGH-registered Core Facility, available on a fee-for-service basis. All aspects of microscopy from basic wide-field and fluorescence imaging, confocal imaging, live cell imaging and TIRF (total internal reflection microscopy), and electron microscopy are available. The official Core website provides more details regarding equipment, cost and contact information. To access the core, please contact the appropriate persons (Dennis Brown for general inquiries, Robert Tyszkowski for light and confocal microscopy, and Diane Capen for EM work and sectioning).

Recent Publications

Behzadi S, Serpooshan V, Tao W, Hamaly MA, Alkawareek MY, Dreaden EC, Brown D, Alkilany AM, Farokhzad OC, Mahmoudi M
Cellular uptake of nanoparticles: journey inside the cell.
Chem Soc Rev. 2017;46(14):4218-4244 - PMID: 28585944
Wang CY, Core AB, Canali S, Zumbrennen-Bullough KB, Ozer S, Umans L, Zwijsen A, Babitt JL
Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice.
Blood. 2017;130(1):73-83 - PMID: 28438754 - PMCID: PMC5501149
Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M
Macrophages Facilitate Electrical Conduction in the Heart
Cell. 2017;169:510-522 - PMID: 28431249 - PMCID: PMC5474950
Mamuya FA, Xie D, Lei L, Huang M, Tsuji K, Capen DE, Yang B, Weissleder R, Păunescu TG, Lu HJ
Deletion of β-1 integrin in collecting duct principal cells leads to tubular injury and renal medullary fibrosis.
Am J Physiol Renal Physiol. 2017;:ajprenal.00038.2017 - PMID: 28701310

Recent News

2017-04-20: Science features CSB research on macrophages in the heart - (pdf)
2016-02-11: Dennis Brown, PhD, Professor of Medicine and Director of the MGH Program in Membrane Biology, part of the Division of Nephrology and the Center for Systems Biology, was elected by a poll of its members as the new President Elect of the American Physiological Society (APS). Established in 1887, the American Physiological Society (APS) was the first U.S. society in the biomedical sciences field. The Society represents more than 11,000 members and publishes 14 peer-reviewed journals with a worldwide readership.
2015-08-26: Jenny Lu, MD, PhD is the recipient of the 2015 S&R Foundation Ryuji Ueno Award. Congratulations, Jenny!
2014-10-20: A multidisciplinary team lead by Dr. Herbert Y. Lin and including CSB members Dr. Dennis Ausiello, Dr. Stanley Shaw, and Dr. Ravi Thadhani, Chief of Nephrology, working with Professor Michael Cima of the MIT Dept. of Materials Science and Engineering, have won a MGH-MIT Strategic Partnership Grand Challenge in Diagnostics larger grant. The award will support the development of a portable, noninvasive device capable of accurately measuring blood volume using nuclear magnetic resonance (NMR). In addition, Dr. Lin is a Co-Investigator on a winning smaller grant lead by Dr. Anthony Samir of the Department of Radiology for the adaptation of an optical system for localizing the position of ultrasound transducers, which compensates for individual operator differences, to the noninvasive monitoring of tissue loss in chronic kidney disease. (pdf) A National Public Radio interview and article related to the MGH-MIT Grand Challenge grants featuring Drs. Lin, Ausiello and Cima appeared recently.
2014-07-14: CSB PMB work on high resolution imaging of the kidney using helium ion microscopy (Rice et al., PLoSONE 8(3); e57051, 2013) was featured recently in the annual report from the NIDDK (Recent Advances and Emerging Opportunities) under the heading “A closer look at kidney structure”. (pdf)