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Dennis Brown's Lab

Current Projects

The theme of the laboratory (Program in Membrane Biology, PMB) is to understand how membrane transport vesicles interact with accessory proteins (GTPases, SNAREs, kinases) and with the cytoskeleton (microtubules, actin, and PDZ proteins) to modulate cell function via various membrane transport proteins in physiological and pathophysiological conditions. Experimental models used range from in vitro systems using purified proteins and membrane vesicles (endosomes, Golgi, plasma membrane), to transfected cell cultures, to whole animal models including transgenic mice. All projects are interactive and involve cell biological procedures such as confocal and EM-gold immunocytochemistry, real time confocal and TIRF microscopy. In addition, molecular and biochemical procedures are combined with cell biology to provide a multidisciplinary approach to problem solving. The aim of the research is to understand how physiologically-relevant processes of fluid and electrolyte transport across epithelia are regulated at the cell and molecular levels in kidney, the male reproductive tract and other organ systems.

Recent Publications (more...)

Nigwekar SU, Weiser JM, Kalim S, Xu D, Wibecan JL, Dougherty SM, Mercier-Lafond L, Corapi KM, Eneanya ND, Holbrook EH, Brown D, Thadhani RI, Păunescu TG
Characterization and Correction of Olfactory Deficits in Kidney Disease.
J Am Soc Nephrol. 2017;:ePub - PMID: 28775001
Behzadi S, Serpooshan V, Tao W, Hamaly MA, Alkawareek MY, Dreaden EC, Brown D, Alkilany AM, Farokhzad OC, Mahmoudi M
Cellular uptake of nanoparticles: journey inside the cell.
Chem Soc Rev. 2017;46(14):4218-4244 - PMID: 28585944 - PMCID: PMC5593313
Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M
Macrophages Facilitate Electrical Conduction in the Heart
Cell. 2017;169:510-522 - PMID: 28431249 - PMCID: PMC5474950
Li W, Jin WW, Tsuji K, Chen Y, Nomura N, Su L, Yui N, Arthur J, Cotecchia S, Păunescu TG, Brown D, Lu HAJ
Direct interaction of ezrin and AQP2 and its role in AQP2 trafficking.
J Cell Sci. 2017;130(17):2914-2925 - PMID: 28754689

Recent News (more...)

2016-02-11: Dennis Brown, PhD, Professor of Medicine and Director of the MGH Program in Membrane Biology, part of the Division of Nephrology and the Center for Systems Biology, was elected by a poll of its members as the new President Elect of the American Physiological Society (APS). Established in 1887, the American Physiological Society (APS) was the first U.S. society in the biomedical sciences field. The Society represents more than 11,000 members and publishes 14 peer-reviewed journals with a worldwide readership.
2014-07-14: CSB PMB work on high resolution imaging of the kidney using helium ion microscopy (Rice et al., PLoSONE 8(3); e57051, 2013) was featured recently in the annual report from the NIDDK (Recent Advances and Emerging Opportunities) under the heading “A closer look at kidney structure”. (pdf)
2013-07-29: Congratulations to Dennis Brown, PhD, who was awarded an Honorary Doctorate of Science by his alma mater, the University of East Anglia, Norwich, UK at a congregation held on Thursday July 18th, 2013. The honor was bestowed in recognition of his contributions to cell biology and physiology. The following week on July 25th, he gave the prestigious Robert Pitts Lecture in Renal Physiology at the International Union of Physiological Sciences meeting in Birmingham, UK
2012-05-11: Dennis Brown, PhD received the 2012 Joseph B. Martin Dean’s Award for Leadership in the Advancement of Women at Harvard Medical School and Harvard School of Dental Medicine. This prestigious award is co-sponsored by the Joint Committee on the Status of Women and the Dean of the Faculty of Medicine. It was initiated by Dean Joseph B. Martin in 1998 to recognize Harvard faculty and staff members committed to the recruitment, retention, and advancement of women at Harvard Medical School and Harvard School of Dental Medicine. Over the past 25 years, Dr. Brown recruited and trained over 30 female scientists. While some are currently working with Dennis, others are occupying senior academic positions at institutions around the globe. Congratulations Dennis for a well-deserved award!
2011-11-14: The MGH Center for Faculty Development is pleased to announce that Dennis Brown, PhD will assume the position of Director, Office for Research Career Development effective December 1, 2011