Dennis Brown's Lab
The theme of the laboratory (Program in Membrane Biology, PMB) is to understand how membrane transport
vesicles interact with accessory proteins (GTPases, SNAREs, kinases) and with the cytoskeleton
(microtubules, actin, and PDZ proteins) to modulate cell function via various membrane transport
proteins in physiological and pathophysiological conditions. Experimental models used range from
in vitro systems using purified proteins and membrane vesicles (endosomes, Golgi, plasma membrane),
to transfected cell cultures, to whole animal models including transgenic mice. All projects are
interactive and involve cell biological procedures such as confocal and EM-gold immunocytochemistry,
real time confocal and TIRF microscopy. In addition, molecular and biochemical procedures are
combined with cell biology to provide a multidisciplinary approach to problem solving. The aim of
the research is to understand how physiologically-relevant processes of fluid and electrolyte
transport across epithelia are regulated at the cell and molecular levels in kidney, the male
reproductive tract and other organ systems.
Covalent Modulators of the Vacuolar ATPase.
Intercalated Cell Depletion and Vacuolar H+-ATPase Mistargeting in an AE1 R607H Knockin Model.
J Am Soc Nephrol. 2016;:ePub - PMID: 27932475
Renal Atp6ap2/(Pro)renin Receptor Is Required for Normal Vacuolar H+-ATPase Function but Not for the Renin-Angiotensin System.
The V-ATPase is expressed in the choroid plexus and mediates cAMP-induced intracellular pH alterations.
2016-02-11: Dennis Brown, PhD
, Professor of Medicine and Director of the MGH Program in Membrane Biology, part of the Division of Nephrology and the Center for Systems Biology, was elected by a poll of its members as the new President Elect of the American Physiological Society (APS)
. Established in 1887, the American Physiological Society (APS) was the first U.S. society in the biomedical sciences field. The Society represents more than 11,000 members and publishes 14 peer-reviewed journals with a worldwide readership.
Congratulations to Dennis Brown, PhD, who was awarded an Honorary Doctorate of Science by his alma mater, the University of East Anglia
, Norwich, UK at a congregation held on Thursday July 18th, 2013. The honor was bestowed in recognition of his contributions to cell biology and physiology. The following week on July 25th, he gave the prestigious Robert Pitts Lecture in Renal Physiology at the International Union of Physiological Sciences meeting in Birmingham, UK
2012-05-11: Dennis Brown, PhD
received the 2012 Joseph B. Martin Dean’s Award for Leadership in the Advancement of Women at Harvard Medical School and Harvard School of Dental Medicine
. This prestigious award is co-sponsored by the Joint Committee on the Status of Women and the Dean of the Faculty of Medicine. It was initiated by Dean Joseph B. Martin in 1998 to recognize Harvard faculty and staff members committed to the recruitment, retention, and advancement of women at Harvard Medical School and Harvard School of Dental Medicine. Over the past 25 years, Dr. Brown recruited and trained over 30 female scientists. While some are currently working with Dennis, others are occupying senior academic positions at institutions around the globe. Congratulations Dennis for a well-deserved award!