About

Dennis Brown's Lab

Current Projects

The theme of the laboratory (Program in Membrane Biology, PMB) is to understand how membrane transport vesicles interact with accessory proteins (GTPases, SNAREs, kinases) and with the cytoskeleton (microtubules, actin, and PDZ proteins) to modulate cell function via various membrane transport proteins in physiological and pathophysiological conditions. Experimental models used range from in vitro systems using purified proteins and membrane vesicles (endosomes, Golgi, plasma membrane), to transfected cell cultures, to whole animal models including transgenic mice. All projects are interactive and involve cell biological procedures such as confocal and EM-gold immunocytochemistry, real time confocal and TIRF microscopy. In addition, molecular and biochemical procedures are combined with cell biology to provide a multidisciplinary approach to problem solving. The aim of the research is to understand how physiologically-relevant processes of fluid and electrolyte transport across epithelia are regulated at the cell and molecular levels in kidney, the male reproductive tract and other organ systems.

Recent Publications (more...)

Little MH, Brown D, Humphreys BD, McMahon AP, Miner JH, Sands JM, Weisz OA, Mullins C, Hoshizaki D,
Defining Kidney Biology to Understand Renal Disease.
Clin J Am Soc Nephrol. 2013;9(4):809-11 - PMID: 24370769
Paunescu TG, Lu HA, Russo LM, Pastor-Soler NM, McKee M, McLaughlin MM, Bartlett BE, Breton S, Brown D
Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells.
Am J Physiol Renal Physiol. 2013;305(12):F1783-F1795 - PMID: 24133120 - PMCID: PMC3882446
Breton S, Brown D
Regulation of Luminal Acidification by the V-ATPase.
Physiology (Bethesda). 2013;28(5):318-29 - PMID: 23997191 - PMCID: PMC3768094
Shum W, Hill E, Brown D, Breton S
Plasticity of basal cells during postnatal development in the rat epididymis.
Reproduction. 2013;146(5):455-469 - PMID: 23960170

Recent News (more...)

2013-07-29: Congratulations to Dennis Brown, PhD, who was awarded an Honorary Doctorate of Science by his alma mater, the University of East Anglia, Norwich, UK at a congregation held on Thursday July 18th, 2013. The honor was bestowed in recognition of his contributions to cell biology and physiology. The following week on July 25th, he gave the prestigious Robert Pitts Lecture in Renal Physiology at the International Union of Physiological Sciences meeting in Birmingham, UK
2012-05-11: Dennis Brown, PhD received the 2012 Joseph B. Martin Dean’s Award for Leadership in the Advancement of Women at Harvard Medical School and Harvard School of Dental Medicine. This prestigious award is co-sponsored by the Joint Committee on the Status of Women and the Dean of the Faculty of Medicine. It was initiated by Dean Joseph B. Martin in 1998 to recognize Harvard faculty and staff members committed to the recruitment, retention, and advancement of women at Harvard Medical School and Harvard School of Dental Medicine. Over the past 25 years, Dr. Brown recruited and trained over 30 female scientists. While some are currently working with Dennis, others are occupying senior academic positions at institutions around the globe. Congratulations Dennis for a well-deserved award!
2011-11-14: The MGH Center for Faculty Development is pleased to announce that Dennis Brown, PhD will assume the position of Director, Office for Research Career Development effective December 1, 2011
2011-02-17: Dennis Brown, PhD has been elected to serve on The National Council of the American Physiological Society

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