Pittet

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Mikael Pittet’s Lab

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My laboratory performs a research program on the host immune response in vivo with the main goal to offer valuable new ways to combat cancer. We use various modalities, including in vivo imaging, to study where, when and how immune cells are produced, traffic, and mediate regulatory or effector functions. The studies make use of both genetic mouse models, which allow manipulations and analyses of mechanisms and causality, and human patient material, to ensure that the results are anchored in clinical correlates. This dual approach gives opportunities for discovery of novel contributions of the immune response to tumor progression, new biomarkers useful for diagnosis and prognosis, and novel targets for therapeutic intervention. Dr. Pittet directs Cancer Immunology Program at CSB and collaborates with several immunology programs at Harvard Medical School, Massachusetts General Hospital and Massachusetts Institute of Technology.

In vivo imaging of immune cells at different scales.
Imaging modalities include single photon emission computed
tomography – X-ray computed tomography (SPECT-CT), fluorescence
mediated tomography (FMT), microscopic fiber optics, and intravital
multiphoton microscopy (IVM).

Recent Publications (more...)

Garris CS*, Arlauckas SP*, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ
Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12
Immunity. 2018;49:1-14 - DOI: 10.1016/j.immuni.2018.09.024
Kim HY, Li R, Ng TSC, Courties G, Rodell CB, Prytyskach M, Kohler RH, Pittet M, Nahrendorf M, Weissleder R, Miller MA
Quantitative Imaging of Tumor Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin.
ACS Nano. 2018;:ePub - PMID: 30508377 - DOI: 10.1021/acsnano.8b04338
Arlauckas SP*, Garren SB*, Garris CS, Kohler RH, Oh J, Pittet MJ, Weissleder R
Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages
Theranostics. 2018;8(21):5842-5854 - DOI: 10.7150/thno.26888
Oh J, Magnuson A, Benoist C, Pittet MJ, Weissleder R
Age-related tumor growth in mice is related to integrin α 4 in CD8+ T cells
JCI Insight. 2018;3(21):ePub - PMID: 30385729 - PMCID: PMC6238736 - DOI: 10.1172/jci.insight.122961

Recent News (more...)

2018-12-11: “A small population of immune cells is key for successful cancer immunotherapy” - Study by Garris et al. from the Pittet Lab. See also interview with the authors.
2018-10-02: The Cover of Science Immunology's September issue features our hand-drawn sketch of a microscopy room used for intravital imaging and discussed in this review.
2018-09-30: "Our review on single cell imaging to study the immune system is out. We discuss how intravital imaging can be used to “record the wild lives of immune cells" in various tissues. We also provide a comprehensive overview of mouse reporter lines to track many types of immune cells in vivo.
2018-04-06: Congratulations to Camilla Engblom from the PittetLab, whose paper entitled "Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils” and published in Science in December 2017 has been named Select Paper of the Year 2017 from the Graduate Student Division.
2018-04-04: The work of Pittet Lab is featured in The Scientist - "Macrophages Play a Double Role in Cancer".