Mikael Pittet’s Lab

Follow us @PittetLab

My laboratory performs a research program on the host immune response in vivo with the main goal to offer valuable new ways to combat cancer. We use various modalities, including in vivo imaging, to study where, when and how immune cells are produced, traffic, and mediate regulatory or effector functions. The studies make use of both genetic mouse models, which allow manipulations and analyses of mechanisms and causality, and human patient material, to ensure that the results are anchored in clinical correlates. This dual approach gives opportunities for discovery of novel contributions of the immune response to tumor progression, new biomarkers useful for diagnosis and prognosis, and novel targets for therapeutic intervention. Dr. Pittet directs Cancer Immunology Program at CSB and collaborates with several immunology programs at Harvard Medical School, Massachusetts General Hospital and Massachusetts Institute of Technology.

In vivo imaging of immune cells at different scales.
Imaging modalities include single photon emission computed
tomography – X-ray computed tomography (SPECT-CT), fluorescence
mediated tomography (FMT), microscopic fiber optics, and intravital
multiphoton microscopy (IVM).

Recent Publications (more...)

Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, Kohler RH, Pittet MJ, Weissleder R
TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.
Nature Biomedical Engineering. 2018;:ePub - DOI: 10.1038/s41551-018-0236-8
Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM, Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, Vonderheide RH, Pittet MJ, Jain RK, Zou W, Howcroft TK, Woodhouse EC, Weinberg RA, Krummel MF
Understanding the tumor immune microenvironment (TIME) for effective therapy.
Nature Med. 2018;24(5):541-550 - PMID: 29686425 - PMCID: PMC5998822 - DOI: 10.1038/s41591-018-0014-x
Engblom C*, Pfirschke C*, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ
Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils
Science. 2017;358:eaal5081 - PMID: 29191879 - DOI: 10.1126/science.aal5081
Miller MA, Kim E, Cuccarese MF, Plotkin AL, Prytyskach M, Kohler RH, Pittet MJ, Weissleder R
Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease
Chem Commun. 2017;54(1):42-45 - PMID: 29185561 - PMCID: PMC5736449 - DOI: 10.1039/c7cc07581b

Recent News (more...)

2018-04-06: Congratulations to Camilla Engblom from the PittetLab, whose paper entitled "Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils” and published in Science in December 2017 has been named Select Paper of the Year 2017 from the Graduate Student Division.
2018-04-04: The work of Pittet Lab is featured in The Scientist - "Macrophages Play a Double Role in Cancer".
2018-01-25: Congrats to Cécile Piot from the @PittetLab who was awarded a scholarship from the EPFL WISH foundation! The foundation supports promising women in their goal to make a carrier in science, architecture or engineering and who are accepted in prestigious schools for their master thesis.
2017-12-01: "Tumors talk to bones, and bones answer back" - Study by Engblom, Pfirschke et al. from the Pittet Lab is featured in Science and Nature. See also interview with the authors.
2017-09-11: "Uncovering Cancer" - the work of Pittet Lab is featured in Nature Medicine article.