Mikael Pittet's Lab

My laboratory performs a research program on the host immune response in vivo with the main goal to offer valuable new ways to combat cancer. We use various modalities, including in vivo imaging, to study where, when and how immune cells are produced, traffic, and mediate regulatory or effector functions. The studies make use of both genetic mouse models, which allow manipulations and analyses of mechanisms and causality, and human patient material, to ensure that the results are anchored in clinical correlates. This dual approach gives opportunities for discovery of novel contributions of the immune response to tumor progression, new biomarkers useful for diagnosis and prognosis, and novel targets for therapeutic intervention. The laboratory is part of the Immunology Program at CSB and collaborates with several immunology programs at Harvard Medical School, Massachusetts General Hospital and Massachusetts Institute of Technology.

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In vivo imaging of immune cells at different scales. Imaging modalities include single photon emission computed tomography - X-ray computed tomography (SPECT-CT), fluorescence mediated tomography (FMT), microscopic fiber optics, and intravital multiphoton microscopy (IVM).

Recent Publications (more...)

Pfirschke C, Garris C, Pittet MJ
Common TLR5 Mutations Control Cancer Progression.
Cancer Cell. 2015;27(1):1-3 - PMID: 25584886
Viaud S, Daillère R, Boneca IG, Lepage P, Pittet MJ, Ghiringhelli F, Trinchieri G, Goldszmid R, Zitvogel L
Harnessing the Intestinal Microbiome for Optimal Therapeutic Immunomodulation.
Cancer Res. 2014;74(16):4217-4221 - PMID: 25074615
Viaud S, Daillère R, Boneca IG, Lepage P, Langella P, Chamaillard M, Pittet MJ, Ghiringhelli F, Trinchieri G, Goldszmid R, Zitvogel L
Gut microbiome and anticancer immune response: really hot Sh*t!
Cell Death Differ. 2014;22(2):199-214 - PMID: 24832470 - PMCID: PMC4291500
Sistigu A, Yamazaki T, Vacchelli E, Chaba K, Enot DP, Adam J, Vitale I, Goubar A, Baracco EE, Remédios C, Fend L, Hannani D, Aymeric L, Ma Y, Niso-Santano M, Kepp O, Schultze JL, Tüting T, Belardelli F, Bracci L, La Sorsa V, Ziccheddu G, Sestili P, Urbani F, Delorenzi M, Lacroix-Triki M, Quidville V, Conforti R, Spano JP, Pusztai L, Poirier-Colame V, Delaloge S, Penault-Llorca F, Ladoire S, Arnould L, Cyrta J, Dessoliers MC, Eggermont A, Bianchi ME, Pittet M, Engblom C, Pfirschke C, Préville X, Uzè G, Schreiber RD, Chow MT, Smyth MJ, Proietti E, André F, Kroemer G, Zitvogel L
Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy.
Nat Med. 2014;20(11):1301-9 - PMID: 25344738

Recent News (more...)

2014-04-25: Christopher Garris has been named a Manfred Karnovsky Fellow in recognition of his achievement in his first years of study in the Division of Medical Sciences at Harvard Medical School. Congratulations Chris!
2014-02-14: Congratulations to Camilla Engblom for obtaining a PhD Fellowship from Boehringer Ingelheim Fonds.
2014-02-02: Enjoy the February 2014 cover of Nature Materials.
2013-10-24: Welcome to Kelsey Finn to the Pittet Lab
2013-05-21: Congratulations to Christina Pfirschke who has been awarded a DFG research fellowship award.