Swirski Lab

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Phone: 617-724-6242

Our goal is to understand how inflammation protects from and contributes to cardiometabolic, infectious, and neurodegenerative diseases. We are interested in elucidating how neural circuits communicate with the immune system to anticipate danger and how metabolic pathways allocate resources to either license or restrict leukocyte production and function.

Specific projects in the lab include those that build on previous work, such as monocyte and macrophage function in atherosclerosis (J Clin Invest 2007; Nat Med 2013), immune inflammatory mechanisms in the heart (J Exp Med 2007; Science 2009; J Exp Med 2017; J Exp Med 2019), the influence of sleep on inflammation (Nature 2019), and the links between the immune system and metabolism (Nat Med 2016; Nature 2019). We collaborate closely with the Nahrendorf Lab.

Recent Publications

  • Schloss MJ, Swirski FK, Nahrendorf M Modifiable Cardiovascular Risk, Hematopoiesis, and Innate Immunity. Circ Res. 2020;126(9):1242-1259 - PMID: 32324501 - PMCID: PMC7185037 - DOI: 10.1161/CIRCRESAHA.120.315936

  • Hoyer FF, Zhang X, Coppin E, Vasamsetti SB, Modugu G, Schloss MJ, Rohde D, McAlpine CS, Iwamoto Y, Libby P, Naxerova K, Swirski FK, Dutta P, Nahrendorf M Bone Marrow Endothelial Cells Regulate Myelopoiesis in Diabetes. Circulation. 2020;:ePub - PMID: 32316750 - DOI: 10.1161/CIRCULATIONAHA.120.046038

  • Senders ML, Meerwaldt AE, van Leent MMT, Sanchez-Gaytan BL, van de Voort JC, Toner YC, Maier A, Klein ED, Sullivan NAT, Sofias AM, Groenen H, Faries C, Oosterwijk RS, van Leeuwen EM, Fay F, Chepurko E, Reiner T, Duivenvoorden R, Zangi L, Dijkhuizen RM, Hak S, Swirski FK, Nahrendorf M, PĂ©rez-Medina C, Teunissen AJP, Fayad ZA, Calcagno C, Strijkers GJ, Mulder WJM Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging. Nat Nanotechnol. 2020;15(5):398-405 - PMID: 32313216 - DOI: 10.1038/s41565-020-0642-4

  • Poller WC, Nahrendorf M, Swirski FK Hematopoiesis and Cardiovascular Disease. Circ Res. 2020;126(8):1061-1085 - PMID: 32271679 - PMCID: PMC7153537 - DOI: 10.1161/CIRCRESAHA.120.315895

  • Figueiredo JL, Santa-Cruz F, Lima-Filho JL, Hilgendorf I, Aikawa M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK, Robbins CS A durable murine model of spleen transplantation with arterial and venous anastomoses. Sci Rep. 2020;10(1):3979 - PMID: 32132617 - PMCID: PMC7055260 - DOI: 10.1038/s41598-020-60983-7

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Research projects

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