Filip Swirski

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Filip Swirski's Lab

About

Our lab seeks to elucidate how leukocytes shape and are shaped by inflammation. We work with models of acute and chronic inflammation relevant to infectious, cardiovascular, and metabolic diseases, and focus on cell development, communication, and function. We think that diversity of inflammatory conditions arises from the tension between conserved cell behaviors and specific tissue contexts. We collaborate with clinical investigators to translate our fundamental discoveries to better understand, and ultimately improve, human health.

Specific projects in the lab include those that build on previous work, such as monocyte and macrophage function in atherosclerosis (J Clin Invest 2007; Nat Med 2013; Science 2013), mechanisms orchestrating wound healing after myocardial infarction (J Exp Med 2007; Science 2009), and the role of IRA B cells in infection (Science 2012; J Exp Med 2014; Science 2015). New projects in the lab aim to define how sleep influences hematopoiesis and atherosclerosis, how hematopoietic growth factors control myocardial inflammation, how inflammation bears upon Alzheimer’s Disease, and how iron is recycled and controlled during dyserythropoietic anemias and anemias of inflammation. We interact closely with the Nahrendorf lab and are part of an International Symposium to study Systemic Inflammatory Networks in Ischemic Heart Disease

Recent Publications (more...)

Braza MS, van Leent MMT, Lameijer M, Sanchez-Gaytan BL, Arts RJW, Pérez-Medina C, Conde P, Garcia MR, Gonzalez-Perez M, Brahmachary M, Fay F, Kluza E, Kossatz S, Dress RJ, Salem F, Rialdi A, Reiner T, Boros P, Strijkers GJ, Calcagno CC, Ginhoux F, Marazzi I, Lutgens E, Nicolaes GAF, Weber C, Swirski FK, Nahrendorf M, Fisher EA, Duivenvoorden R, Fayad ZA, Netea MG, Mulder WJM, Ochando J
Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance.
Immunity. 2018;49(5):819-828.e6 - PMID: 30413362 - PMCID: PMC6251711 - DOI: 10.1016/j.immuni.2018.09.008
Hulsmans M, Aguirre AD, Bonner M, Bapat A, Cremer S, Iwamoto Y, King KR, Swirski FK, Milan DJ, Weissleder R, Nahrendorf M
Miniaturized, Programmable Pacemaker for Long-Term Studies in the Mouse
Circ Res. 2018;:ePub - DOI: 10.1161/CIRCRESAHA.118.313429
Fayad ZA, Swirski FK, Calcagno C, Robbins CS, Mulder W, Kovacic JC
Monocyte and Macrophage Dynamics in the Cardiovascular System: JACC Macrophage in CVD Series (Part 3).
J Am Coll Cardiol. 2018;72(18):2198-2212 - PMID: 30360828 - PMCID: PMC6258199 - DOI: 10.1016/j.jacc.2018.08.2150
Swirski FK
Rings of Fire.
Arterioscler Thromb Vasc Biol. 2018;38(8):1671-1672 - PMID: 30354199 - DOI: 10.1161/ATVBAHA.118.311389

Recent News (more...)

2018-06-18: Christopher T. Chan, Hsing-Ying Lin, and Jouha Min were named the winners of the 2018 MGH Research Fellow Poster Celebration. Congratulations!
2018-05-10: "Leaders In Cardiovascular Science" - Circulation Research profiles Fil Swirski. (pdf)
2018-04-11: CSB work is featured on the MGH Blog.
2017-06-27: The Nahrendorf and Swirski labs at the 2017 Atherosclerosis Gordon Conference, which elected Fil Swirski as 2021 conference chair.