Filip Swirski's Lab
Leukocytes are keepers of the immune system. Heterogeneous and functionally specialized, leukocytes maintain host integrity and defend against dangerous and infectious agents. As primarily motile and migratory, leukocytes can influence each other across distant and diverse environments. These interactions are the basis of immunity; collectively, they represent a leukocyte 'interactome'. The primary goal of the lab is to identify and elucidate how leukocyte communication shapes the course of disease. We ask: What are the spatial, ontogenic, and functional relationships between leukocyte subsets in health and disease? What are the environmental and internal cues that control the balance between leukocyte commitment and plasticity? How is hierarchy maintained in a heteroarchical system?
The immune system is essential to survival, but it can also inflict damage. We are an immunology lab that investigates basic processs of innate immunity in the context of cardiovascular and infectious diseases. We interact closely with members of the Immunology Program at the Center for Systems Biology who investigate a range of other acute and chronic diseases.
Experiments utilize state-of-the-art animal models, classical cell biology tools, molecular profiling, and in vivo molecular imaging technologies that interrogate cell biology at multiple resolutions, from the whole animal to a single cell. Please inquire about availability.