Filip Swirski's Lab
Our goal is to understand how inflammation protects from and contributes to cardiometabolic, infectious, and neurodegenerative diseases. We are interested in elucidating how neural circuits communicate with the immune system to anticipate danger and how metabolic pathways allocate resources to either license or restrict leukocyte production and function.
Specific projects in the lab include those that build on previous work, such as monocyte and macrophage function in atherosclerosis (J Clin Invest 2007; Nat Med 2013), immune inflammatory mechanisms in the heart (J Exp Med 2007; Science 2009; J Exp Med 2017; J Exp Med 2019), the influence of sleep on inflammation (Nature 2019), and the links between the immune system and metabolism (Nat Med 2016; Nature 2019). We collaborate closely with the Nahrendorf Lab.