Filip Swirski

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Filip Swirski's Lab

About

Our lab seeks to elucidate how leukocytes shape and are shaped by inflammation. We work with models of acute and chronic inflammation relevant to infectious, cardiovascular, and metabolic diseases, and focus on cell development, communication, and function. We think that diversity of inflammatory conditions arises from the tension between conserved cell behaviors and specific tissue contexts. We collaborate with clinical investigators to translate our fundamental discoveries to better understand, and ultimately improve, human health.

Specific projects in the lab include those that build on previous work, such as monocyte and macrophage function in atherosclerosis (J Clin Invest 2007; Nat Med 2013; Science 2013), mechanisms orchestrating wound healing after myocardial infarction (J Exp Med 2007; Science 2009), and the role of IRA B cells in infection (Science 2012; J Exp Med 2014; Science 2015). New projects in the lab aim to define how sleep influences hematopoiesis and atherosclerosis, how hematopoietic growth factors control myocardial inflammation, how inflammation bears upon Alzheimer’s Disease, and how iron is recycled and controlled during dyserythropoietic anemias and anemias of inflammation. We interact closely with the Nahrendorf lab and are part of an International Symposium to study Systemic Inflammatory Networks in Ischemic Heart Disease

Recent Publications (more...)

Min J, Nothing M, Coble B, Zheng H, Park J, Im H, Weber GF, Castro CM, Swirski FK, Weissleder R, Lee H
Integrated Biosensor for Rapid and Point-Of-Care Sepsis Diagnosis.
ACS Nano. 2018;:ePub - PMID: 29533646 - DOI: 10.1021/acsnano.7b08965
Swirski FK, Nahrendorf M
Clonal Hematopoiesis Wages War on the Myocardium.
J Am Coll Cardiol. 2018;71(8):887-889 - PMID: 29471940 - DOI: 10.1016/j.jacc.2017.12.038
Hulsmans M, Sager HB, Roh JD, Valero-Muñoz M, Houstis NE, Iwamoto Y, Sun Y, Wilson RM, Wojtkiewicz G, Tricot B, Osborne MT, Hung J, Vinegoni C, Naxerova K, Sosnovik DE, Zile MR, Bradshaw AD, Liao R, Tawakol A, Weissleder R, Rosenzweig A, Swirski FK, Sam F, Nahrendorf M
Cardiac macrophages promote diastolic dysfunction.
J Exp Med. 2018;215(2):423-440 - PMID: 29339450 - PMCID: PMC5789416 - DOI: 10.1084/jem.20171274 - Cover
Nairz M, Haschka D, Dichtl S, Sonnweber T, Schroll A, Aßhoff M, Mindur JE, Moser PL, Wolf D, Swirski FK, Theurl I, Cerami A, Brines M, Weiss G
Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis.
Sci Rep. 2017;7(1):13012 - PMID: 29026145 - PMCID: PMC5638901 - DOI: 10.1038/s41598-017-13046-3

Recent News (more...)

2018-04-11: CSB work is featured on the MGH Blog.
2017-06-27: The Nahrendorf and Swirski labs at the 2017 Atherosclerosis Gordon Conference, which elected Fil Swirski as 2021 conference chair.
2017-05-05: American Heart Association selected Fil Swirski, PhD to receive the 2017 Jeffrey M. Hoeg Award for Basic Science & Clinical Research. Congratulations, Fil!
2017-03-17: Fil Swirski, PhD is a recipient of the inaugural Outstanding Investigator Award from the NHLBI and the Established Investigator Award from the American Heart Association. Congratulations, Fil!