Swirski Lab

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Phone: 617-724-6242

Our goal is to understand how inflammation protects from and contributes to cardiometabolic, infectious, and neurodegenerative diseases. We are interested in elucidating how neural circuits communicate with the immune system to anticipate danger and how metabolic pathways allocate resources to either license or restrict leukocyte production and function.

Specific projects in the lab include those that build on previous work, such as monocyte and macrophage function in atherosclerosis (J Clin Invest 2007; Nat Med 2013), immune inflammatory mechanisms in the heart (J Exp Med 2007; Science 2009; J Exp Med 2017; J Exp Med 2019), the influence of sleep on inflammation (Nature 2019), and the links between the immune system and metabolism (Nat Med 2016; Nature 2019). We collaborate closely with the Nahrendorf Lab.

Recent Publications

  • Figueiredo JL, Santa-Cruz F, Lima-Filho JL, Hilgendorf I, Aikawa M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK, Robbins CS A durable murine model of spleen transplantation with arterial and venous anastomoses. Sci Rep. 2020;10(1):3979 - PMID: 32132617 - PMCID: PMC7055260 - DOI: 10.1038/s41598-020-60983-7

  • Cremer S, Schloss MJ, Vinegoni C, Foy BH, Zhang S, Rohde D, Hulsmans M, Fumene Feruglio P, Schmidt S, Wojtkiewicz G, Higgins JM, Weissleder R, Swirski FK, Nahrendorf M Diminished Reactive Hematopoiesis and Cardiac Inflammation in a Mouse Model of Recurrent Myocardial Infarction. J Am Coll Cardiol. 2020;75(8):901-915 - PMID: 32130926 - DOI: 10.1016/j.jacc.2019.12.056

  • Swirski FK Platelets have a dangerous hold over immune cells in cardiovascular disease. Nature. 2020;577(7790):323-324 - PMID: 31937950 - DOI: 10.1038/d41586-019-03732-9

  • Libby P, Swirski FK, Nahrendorf M The Myocardium: More Than Myocytes. J Am Coll Cardiol. 2019;74(25):3136-3138 - PMID: 31856970 - DOI: 10.1016/j.jacc.2019.10.031

  • Frodermann V, Rohde D, Courties G, Severe N, Schloss MJ, Amatullah H, McAlpine CS, Cremer S, Hoyer FF, Ji F, van Koeverden ID, Herisson F, Honold L, Masson GS, Zhang S, Grune J, Iwamoto Y, Schmidt SP, Wojtkiewicz GR, Lee IH, Gustafsson K, Pasterkamp G, de Jager SCA, Sadreyev RI, MacFadyen J, Libby P, Ridker P, Scadden DT, Naxerova K, Jeffrey KL, Swirski FK, Nahrendorf M Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells. Nature Med. 2019;25(11):1761-1771 - PMID: 31700184 - PMCID: PMC6858591 - DOI: 10.1038/s41591-019-0633-x

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Research projects

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