Filip Swirski

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Filip Swirski's Lab

About

Our lab seeks to elucidate how leukocytes shape and are shaped by inflammation. We work with models of acute and chronic inflammation relevant to infectious, cardiovascular, and metabolic diseases, and focus on cell development, communication, and function. We think that diversity of inflammatory conditions arises from the tension between conserved cell behaviors and specific tissue contexts. We collaborate with clinical investigators to translate our fundamental discoveries to better understand, and ultimately improve, human health.

Specific projects in the lab include those that build on previous work, such as monocyte and macrophage function in atherosclerosis (J Clin Invest 2007; Nat Med 2013; Science 2013), mechanisms orchestrating wound healing after myocardial infarction (J Exp Med 2007; Science 2009), and the role of IRA B cells in infection (Science 2012; J Exp Med 2014; Science 2015). New projects in the lab aim to define how sleep influences hematopoiesis and atherosclerosis, how hematopoietic growth factors control myocardial inflammation, how inflammation bears upon Alzheimer’s Disease, and how iron is recycled and controlled during dyserythropoietic anemias and anemias of inflammation. We interact closely with the Nahrendorf lab and are part of an International Symposium to study Systemic Inflammatory Networks in Ischemic Heart Disease

Recent Publications (more...)

Libby P, Nahrendorf M, Swirski FK
Leukocytes Link Local and Systemic Inflammation in Ischemic Cardiovascular Disease: An Expanded "Cardiovascular Continuum".
J Am Coll Cardiol. 2016;67(9):1091-103 - PMID: 26940931 - PMCID: PMC4779182
Swirski FK, Robbins CS, Nahrendorf M
Development and Function of Arterial and Cardiac Macrophages.
Trends Immunol. 2016;37(1):32-40 - PMID: 26748179 - PMCID: PMC4706986
Ensan S, Li A, Besla R, Degousee N, Cosme J, Roufaiel M, Shikatani EA, El-Maklizi M, Williams JW, Robins L, Li C, Lewis B, Yun TJ, Lee JS, Wieghofer P, Khattar R, Farrokhi K, Byrne J, Ouzounian M, Zavitz CC, Levy GA, Bauer CM, Libby P, Husain M, Swirski FK, Cheong C, Prinz M, Hilgendorf I, Randolph GJ, Epelman S, Gramolini AO, Cybulsky MI, Rubin BB, Robbins CS
Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth
Nat Immunol. 2015;17(2):159-168 - PMID: 26642357
Lindau A, Härdtner C, Hergeth SP, Blanz KD, Dufner B, Hoppe N, Anto-Michel N, Kornemann J, Zou J, Gerhardt LM, Heidt T, Willecke F, Geis S, Stachon P, Wolf D, Libby P, Swirski FK, Robbins CS, McPheat W, Hawley S, Braddock M, Gilsbach R, Hein L, von Zur Mühlen C, Bode C, Zirlik A, Hilgendorf I
Atheroprotection through SYK inhibition fails in established disease when local macrophage proliferation dominates lesion progression.
Basic Res Cardiol. 2016;111(2):20 - PMID: 26891724 - PMCID: PMC4759214

Recent News (more...)

2016-04-06: Fil Swirski, PhD has been selected as a 2016 MGH Research Scholar. Congratulations, Fil!
2015-12-30: Filip Swirski, PhD is the recipient of the 2016 MGH Martin Prize for Fundamental Research. Congratulations, Fil!
2015-06-29: CSB Cardiovascular Program actively participated in the 2015 Atherosclerosis Gordon Research Conference. (participants group photo)
2014-03-26: Filip Swirski, PhD, is the recipient of the 2014 MGH Howard Goodman Fellowship. This highly competitive $300,000 award is intended "to support the pursuit of excellence by young scientists of uncommon passion and ability". Congratulations Fil!
2013-12-12: "Macrophage Accumulation in Atherosclerosis", a commentary on the recent Nature Medicine paper from the Swirski lab, appears in The New England Journal of Medicine. See also the accompanying News and Views on the paper in Nature Medicine