Filip Swirski

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Filip Swirski's Lab

About

Our lab seeks to elucidate how leukocytes shape and are shaped by inflammation. We work with models of acute and chronic inflammation relevant to infectious, cardiovascular, and metabolic diseases, and focus on cell development, communication, and function. We think that diversity of inflammatory conditions arises from the tension between conserved cell behaviors and specific tissue contexts. We collaborate with clinical investigators to translate our fundamental discoveries to better understand, and ultimately improve, human health.

Specific projects in the lab include those that build on previous work, such as monocyte and macrophage function in atherosclerosis (J Clin Invest 2007; Nat Med 2013; Science 2013), mechanisms orchestrating wound healing after myocardial infarction (J Exp Med 2007; Science 2009), and the role of IRA B cells in infection (Science 2012; J Exp Med 2014; Science 2015). New projects in the lab aim to define how sleep influences hematopoiesis and atherosclerosis, how hematopoietic growth factors control myocardial inflammation, how inflammation bears upon Alzheimer’s Disease, and how iron is recycled and controlled during dyserythropoietic anemias and anemias of inflammation. We interact closely with the Nahrendorf lab and are part of an International Symposium to study Systemic Inflammatory Networks in Ischemic Heart Disease

Recent Publications (more...)

Swirski FK
A CRISPR Take on Clonal Hematopoiesis.
Circ Res. 2018;123(3):313-314 - PMID: 30026373 - DOI: 10.1161/CIRCRESAHA.118.313347
Yvan-Charvet L, Swirski FK
Is defective cholesterol efflux an integral inflammatory component in myelopoiesis-driven cardiovascular diseases?
Eur Heart J. 2018;39(23):2168-2171 - PMID: 29771312 - DOI: 10.1093/eurheartj/ehy269
Lameijer M, Binderup T, van Leent MMT, Senders ML, Fay F, Malkus J, Sanchez-Gaytan BL, Teunissen AJP, Karakatsanis N, Robson P, Zhou X, Ye Y, Wojtkiewicz G, Tang J, Seijkens TTP, Kroon J, Stroes ESG, Kjaer A, Ochando J, Reiner T, Pérez-Medina C, Calcagno C, Fischer EA, Zhang B, Temel RE, Swirski FK, Nahrendorf M, Fayad ZA, Lutgens E, Mulder WJM, Duivenvoorden R
Efficacy and safety assessment of a TRAF6- targeted nanoimmunotherapy in atherosclerotic mice and non-human primates
Nature Biomedical Engineering. 2018;2:279–292 - DOI: 10.1038/s41551-018-0221-2
Zhang Y, Dong H, Seeburg DP, Wojtkiewicz GR, Waterman P, Pulli B, Forghani R, Ali M, Iwamoto Y, Swirski FK, Chen JW
Multimodal Molecular Imaging Demonstrates Myeloperoxidase Regulation of Matrix Metalloproteinase Activity in Neuroinflammation.
Mol Neurobiol. 2018;:ePub - PMID: 29808380 - DOI: 10.1007/s12035-018-1137-2

Recent News (more...)

2018-06-18: Christopher T. Chan, Hsing-Ying Lin, and Jouha Min were named the winners of the 2018 MGH Research Fellow Poster Celebration. Congratulations!
2018-05-10: "Leaders In Cardiovascular Science" - Circulation Research profiles Fil Swirski. (pdf)
2018-04-11: CSB work is featured on the MGH Blog.
2017-06-27: The Nahrendorf and Swirski labs at the 2017 Atherosclerosis Gordon Conference, which elected Fil Swirski as 2021 conference chair.