Swirski Lab

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Phone: 617-724-6242

Our goal is to understand how inflammation protects from and contributes to cardiometabolic, infectious, and neurodegenerative diseases. We are interested in elucidating how neural circuits communicate with the immune system to anticipate danger and how metabolic pathways allocate resources to either license or restrict leukocyte production and function.

Specific projects in the lab include those that build on previous work, such as monocyte and macrophage function in atherosclerosis (J Clin Invest 2007; Nat Med 2013), immune inflammatory mechanisms in the heart (J Exp Med 2007; Science 2009; J Exp Med 2017; J Exp Med 2019), the influence of sleep on inflammation (Nature 2019), and the links between the immune system and metabolism (Nat Med 2016; Nature 2019). We collaborate closely with the Nahrendorf Lab.

Recent Publications

  • Swirski FK ESC William Harvey Lecture on Basic Science 2020. Eur Heart J. 2020;41(46):4373-4374 - PMID: 33349865 - DOI: 10.1093/eurheartj/ehaa766

  • Härdtner C, Kornemann J, Krebs K, Ehlert CA, Jander A, Zou J, Starz C, Rauterberg S, Sharipova D, Dufner B, Hoppe N, Dederichs TS, Willecke F, Stachon P, Heidt T, Wolf D, von Zur Mühlen C, Madl J, Kohl P, Kaeser R, Boettler T, Pieterman EJ, Princen HMG, Ho-Tin-Noé B, Swirski FK, Robbins CS, Bode C, Zirlik A, Hilgendorf I Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering. Basic Res Cardiol. 2020;115(6):78 - PMID: 33296022 - PMCID: PMC7725697 - DOI: 10.1007/s00395-020-00838-4

  • Krohn-Grimberghe M, Mitchell MJ, Schloss MJ, Khan OF, Courties G, Guimaraes PPG, Rohde D, Cremer S, Kowalski PS, Sun Y, Tan M, Webster J, Wang K, Iwamoto Y, Schmidt SP, Wojtkiewicz GR, Nayar R, Frodermann V, Hulsmans M, Chung A, Hoyer FF, Swirski FK, Langer R, Anderson DG, Nahrendorf M Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche. Nat Biomed Eng. 2020;4(11):1076-1089 - PMID: 33020600 - PMCID: PMC7655681 - DOI: 10.1038/s41551-020-00623-7

  • Chan CT, Fenn AM, Harder NK, Mindur JE, McAlpine CS, Patel J, Valet C, Rattik S, Iwamoto Y, He S, Anzai A, Kahles F, Poller WC, Janssen H, Wong LP, Fernandez-Hernando C, Koolbergen DR, van der Laan AM, Yvan-Charvet L, Sadreyev RI, Nahrendorf M, Westerterp M, Tall AR, Gustafsson JA, Swirski FK Liver X receptors are required for thymic resilience and T cell output. J Exp Med. 2020;217(10):ePub - PMID: 32716519 - PMCID: PMC7537384 - DOI: 10.1084/jem.20200318

  • Schloss MJ, Swirski FK, Nahrendorf M Modifiable Cardiovascular Risk, Hematopoiesis, and Innate Immunity. Circ Res. 2020;126(9):1242-1259 - PMID: 32324501 - PMCID: PMC7185037 - DOI: 10.1161/CIRCRESAHA.120.315936

  • More publications ...

Research projects

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