Filip Swirski

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Filip Swirski's Lab

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Our goal is to understand how inflammation protects from and contributes to cardiometabolic, infectious, and neurodegenerative diseases. We are interested in elucidating how neural circuits communicate with the immune system to anticipate danger and how metabolic pathways allocate resources to either license or restrict leukocyte production and function.

Specific projects in the lab include those that build on previous work, such as monocyte and macrophage function in atherosclerosis (J Clin Invest 2007; Nat Med 2013), immune inflammatory mechanisms in the heart (J Exp Med 2007; Science 2009; J Exp Med 2017; J Exp Med 2019), the influence of sleep on inflammation (Nature 2019), and the links between the immune system and metabolism (Nat Med 2016; Nature 2019). We collaborate closely with the Nahrendorf Lab.

Recent Publications (more...)

Courties G, Frodermann V, Honold L, Zheng Y, Herisson FE, Schloss MJ, Sun Y, Presumey J, Severe N, Engblom C, Hulsmans M, Cremer S, Rohde D, Pittet MJ, Scadden D, Swirski FK, Kim DE, Moskowitz MA, Nahrendorf M
Glucocorticoids Regulate Bone Marrow B Lymphopoiesis After Stroke.
Circ Res. 2019;124(9):1372-1385 - PMID: 30782088 - PMCID: PMC6483874 - DOI: 10.1161/CIRCRESAHA.118.314518
McAlpine CS, Kiss MG, Rattik S, He S, Vassalli A, Valet C, Anzai A, Chan CT, Mindur JE, Kahles F, Poller WC, Frodermann V, Fenn AM, Gregory AF, Halle L, Iwamoto Y, Hoyer FF, Binder CJ, Libby P, Tafti M, Scammell TE, Nahrendorf M, Swirski FK
Sleep modulates haematopoiesis and protects against atherosclerosis
Nature. 2019;566(7744):383-387 - PMID: 30760925 - PMCID: PMC6442744 - DOI: 10.1038/s41586-019-0948-2
Vromman A, Ruvkun V, Shvartz E, Wojtkiewicz G, Santos Masson G, Tesmenitsky Y, Folco E, Gram H, Nahrendorf M, Swirski FK, Sukhova GK, Libby P
Stage-dependent differential effects of interleukin-1 isoforms on experimental atherosclerosis.
Eur Heart J. 2019;:ePub - PMID: 30698710 - DOI: 10.1093/eurheartj/ehz008
Mindur JE, Swirski FK
Growth Factors as Immunotherapeutic Targets in Cardiovascular Disease.
Arterioscler Thromb Vasc Biol. 2019;:ATVBAHA119311994 - PMID: 31092009 - DOI: 10.1161/ATVBAHA.119.311994

Recent News (more...)

2019-04-05: John Mindur (Swirski Lab) has been awarded an Ruth L. Kirschstein F31 Predoctoral Fellowship from the NHLBI. Congratulations, John!
2019-04-04: Three CSB researchers - Clemens Alt, PhD (Lin Lab), Cameron McAlpine, PhD and Shun He, PhD (Swirski Lab) - won Poster of Distinction award at the Annual Meeting of the MGH Scientific Advisory Committee (SAC). Congratulations!
2018-12-26: Five CSB PIs are on the list of Highly Cited Researchers of 2018. Congratulations to Brad Bernstein, Matthias Nahrendorf, Mikael Pittet, Fil Swirski, and Ralph Weissleder!
2018-06-18: Christopher T. Chan, Hsing-Ying Lin, and Jouha Min were named the winners of the 2018 MGH Research Fellow Poster Celebration. Congratulations!
2018-05-10: "Leaders In Cardiovascular Science" - Circulation Research profiles Fil Swirski. (pdf)