John Chen



John Chen's Group

My laboratory studies neuroinflammation. In particular, we investigate the roles of molecular pathways and innate immune processes related to microglia in multiple sclerosis but also other diseases where CNS inflammation is prominent. A key aspect of our research is in deciphering complex in vivo biology by using innovative molecular imaging technologies, targeted molecular treatments, advanced experimental models as well as human trials. Ultimately we hope advance the diagnosis and treatment of these diseases by developing novel imaging and treatment strategies.


Recent Publications (more...)

Wang C, Keliher E, Zeller MWG, Wojtkiewicz GR, Aguirre AD, Buckbinder L, Kim HY, Chen J, Maresca K, Ahmed MS, Motlagh NJ, Nahrendorf M, Chen JW
An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo.
Proc Natl Acad Sci U S A. 2019;116(24):11966-11971 - PMID: 31123149 - PMCID: PMC6575581 - DOI: 10.1073/pnas.1818434116
Li A, Wu Y, Pulli B, Wojtkiewicz GR, Iwamoto Y, Wang C, Li JH, Ali M, Feng X, Yao Z, Chen JW
Myeloperoxidase Molecular MRI Reveals Synergistic Combination Therapy in Murine Experimental Autoimmune Neuroinflammation.
Radiology. 2019;:182492 - PMID: 31478802 - DOI: 10.1148/radiol.2019182492

Recent News (more...)

2016-08-01: CSB investigators - Mikael Pittet, PhD, Matthias Nahrendorf, MD, PhD, and John Chen, MD, PhD - have been named Distinguished Investigators of the Academy of Radiology Research. Congratulations!
2013-10-24: Benjamin Pulli, MD from the Chen Lab has been chosen by the RSNA Scientific Program Committee to receive the RSNA Travel Award for Young Investigators in Molecular Imaging for abstract "Molecular Magnetic Resonance Immunoradiology Reveals Novel Effect of Interferon-? on Myeloid Cells in Murine Multiple Sclerosis".
2012-12-11: "Imaging Early MS" - An Interview with John Chen, M.D., Ph.D. by Dana Foundation (pdf)
2012-11-29: Benjamin Pulli's work on distinguishing inflammatory liver disease from benign fatty liver was featured in the RSNA Daily Bulletin. (pdf)
2012-01-19: Congressionally Directed Medical Research Programs site highlights work of John Chen, M.D, Ph.D. - New Imaging Agent for Early Lesion Detection and Treatment Tracking in MS. (pdf)