John Chen

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John Chen's Group

My laboratory studies neuroinflammation. In particular, we investigate the roles of molecular pathways and innate immune processes related to microglia in multiple sclerosis but also other diseases where CNS inflammation is prominent. A key aspect of our research is in deciphering complex in vivo biology by using innovative molecular imaging technologies, targeted molecular treatments, advanced experimental models as well as human trials. Ultimately we hope advance the diagnosis and treatment of these diseases by developing novel imaging and treatment strategies.

Workflow

Recent Publications (more...)

Wang C, Keliher E, Zeller MWG, Wojtkiewicz GR, Aguirre AD, Buckbinder L, Kim HY, Chen J, Maresca K, Ahmed MS, Motlagh NJ, Nahrendorf M, Chen JW
An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo.
Proc Natl Acad Sci U S A. 2019;116(24):11966-11971 - PMID: 31123149 - PMCID: PMC6575581 - DOI: 10.1073/pnas.1818434116
Choi SH, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, Clemenson GD, Kim E, Rompala A, Oram MK, Asselin C, Aronson J, Zhang C, Miller SJ, Lesinski A, Chen JW, Kim DY, van Praag H, Spiegelman BM, Gage FH, Tanzi RE
Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model.
Science. 2018;361(6406):ePub - PMID: 30190379 - PMCID: PMC6149542 - DOI: 10.1126/science.aan8821
Chen J, Landegger LD, Sun Y, Ren J, Maimon N, Wu L, Ng MR, Chen JW, Zhang N, Zhao Y, Gao X, Fujita T, Roberge S, Huang P, Jain RK, Plotkin SR, Stankovic KM, Xu L
A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma.
Nat Protoc. 2019;14(2):541-555 - PMID: 30617350 - PMCID: PMC6571021 - DOI: 10.1038/s41596-018-0105-7

Recent News (more...)

2016-08-01: CSB investigators - Mikael Pittet, PhD, Matthias Nahrendorf, MD, PhD, and John Chen, MD, PhD - have been named Distinguished Investigators of the Academy of Radiology Research. Congratulations!
2013-10-24: Benjamin Pulli, MD from the Chen Lab has been chosen by the RSNA Scientific Program Committee to receive the RSNA Travel Award for Young Investigators in Molecular Imaging for abstract "Molecular Magnetic Resonance Immunoradiology Reveals Novel Effect of Interferon-? on Myeloid Cells in Murine Multiple Sclerosis".
2012-12-11: "Imaging Early MS" - An Interview with John Chen, M.D., Ph.D. by Dana Foundation (pdf)
2012-11-29: Benjamin Pulli's work on distinguishing inflammatory liver disease from benign fatty liver was featured in the RSNA Daily Bulletin. (pdf)
2012-01-19: Congressionally Directed Medical Research Programs site highlights work of John Chen, M.D, Ph.D. - New Imaging Agent for Early Lesion Detection and Treatment Tracking in MS. (pdf)