John Chen's Group
My laboratory studies neuroinflammation. In particular, we investigate the roles of molecular pathways and innate immune processes related to microglia in multiple sclerosis but also other diseases where CNS inflammation is prominent. A key aspect of our research is in deciphering complex in vivo biology by using innovative molecular imaging technologies, targeted molecular treatments, advanced experimental models as well as human trials. Ultimately we hope advance the diagnosis and treatment of these diseases by developing novel imaging and treatment strategies.
Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice.
Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease.
In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis.
Molecular MR Imaging of Myeloperoxidase Distinguishes Steatosis from Steatohepatitis in Nonalcoholic Fatty Liver Disease.
Benjamin Pulli, MD from the Chen Lab
has been chosen by the RSNA Scientific Program Committee to receive the RSNA Travel Award for Young Investigators in Molecular Imaging for abstract "Molecular Magnetic Resonance Immunoradiology Reveals Novel Effect of Interferon-? on Myeloid Cells in Murine Multiple Sclerosis".
Benjamin Pulli's work on distinguishing inflammatory liver disease from benign fatty liver was featured in the RSNA Daily Bulletin