John Chen's Group
My laboratory studies neuroinflammation. In particular, we investigate the roles of molecular pathways and innate immune processes related to microglia in multiple sclerosis but also other diseases where CNS inflammation is prominent. A key aspect of our research is in deciphering complex in vivo biology by using innovative molecular imaging technologies, targeted molecular treatments, advanced experimental models as well as human trials. Ultimately we hope advance the diagnosis and treatment of these diseases by developing novel imaging and treatment strategies.
An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo.
Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model.
A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma.
Benjamin Pulli, MD from the Chen Lab
has been chosen by the RSNA Scientific Program Committee to receive the RSNA Travel Award for Young Investigators in Molecular Imaging for abstract "Molecular Magnetic Resonance Immunoradiology Reveals Novel Effect of Interferon-? on Myeloid Cells in Murine Multiple Sclerosis".
Benjamin Pulli's work on distinguishing inflammatory liver disease from benign fatty liver was featured in the RSNA Daily Bulletin