Nahrendorf, Matthias, MD, PhD
My current research interests focus on imaging of molecular processes during the healing phase after myocardial infarction. Imaging targets are innate immune cells. Monocytes and macrophages are key players with a central role in disease, including the development of heart failure. We use the entire spectrum of modalities, including MRI, nuclear and optical imaging techniques. Multimodal imaging, as well as hybrid approaches to fuse molecular data with anatomical information are aspects of particular interest. These technologies are embedded in a biologically driven research program that aims at systematic understanding of inflammation at a basic level while keeping a rigorous translational perspective. In addition, I serve as the Director of the Mouse Imaging Program at the Center for Systems Biology. In this function, I oversee the scientific and administrative aspects of a broad molecular imaging facility that comprises all modalities, lead and mentor a team of post doctoral researchers and technicians and support collaborative imaging projects with outside researchers focussing on cardiovascular disease and cancer.
Selected Publications (from total of 200)
RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction
Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells
Macrophages retain hematopoietic stem cells in the spleen via VCAM-1.
Chronic variable stress activates hematopoietic stem cells
Local proliferation dominates lesional macrophage accumulation in atherosclerosis
Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure.
Myocardial infarction accelerates atherosclerosis
Innate Response Activator B Cells Protect Against Microbial Sepsis
Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis.
Therapeutic siRNA silencing in inflammatory monocytes in mice
In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation
Monocytes: protagonists of infarct inflammation and repair after myocardial infarction.
Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis.
Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions.