Chen, John, MD, PhD
Dr. Chen is an Assistant Professor at Harvard Medical School and Attending Clinician (Neuroradiology) at MGH. Dr. Chen is a graduate of the University of Illinois (MD, PhD in physical chemistry) and completed his radiology residency in 2004 and neuroradiology fellowship at MGH in 2005. He has won several awards including the MGH Wyman Award, RSNA and Dana Foundation Awards, as well as an NIH K08 award. His current research is supported by two NIH R01 and an R21 grants.
Selected Publications (from total of 42)
Demyelinating Diseases: Myeloperoxidase as an Imaging Biomarker and Therapeutic Target.
Ligation of the Jugular Veins Does Not Result in Brain Inflammation or Demyelination in Mice
Vasculitis: Molecular Imaging by Targeting the Inflammatory Enzyme Myeloperoxidase.
Activatable magnetic resonance imaging agents for myeloperoxidase sensing: mechanism of activation, stability, and toxicity.
Enzyme-Sensitive Magnetic Resonance Imaging Targeting Myeloperoxidase Identifies Active Inflammation in Experimental Rabbit Atherosclerotic Plaques.
Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy.
Tracking the Inflammatory Response in Stroke in Vivo by Sensing the Enzyme Myeloperoxidase
Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis.
Brain. 2008;131(Pt 4):1123-33 - PMID: 18234693
Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates
Radiology. 2006;240 (2):473-81 - PMID: 16864673