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IRF3 and type I interferons fuel a fatal response to myocardial infarction
High-Content Biopsies Facilitate Molecular Analyses and Do Not Increase Complication Rates in Patients With Advanced Solid Tumors.
JCO Precis Oncol. 2017;1:1-9 - PMID: 35172508 - DOI: 10.1200/PO.17.00081
Evolution of macromolecular complexity in drug delivery systems.
PD-L1 is an activation-independent marker of brown adipocytes.
Nano-palladium is a cellular catalyst for in vivo chemistry
Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging.
Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease.
Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts
Sci Transl Med. 2017;9(392):eaal0225 - PMID: 28566423 - PMCID: PMC6681815 - DOI: 10.1126/scitranslmed.aal0225
Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy
Sci Transl Med. 2017;9(391):eaal3226 - PMID: 28539469 - PMCID: PMC5846089 - DOI: 10.1126/scitranslmed.aal3226
In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy
Sci Transl Med. 2017;9(389):eaal3604 - PMID: 28490665 - PMCID: PMC5734617 - DOI: 10.1126/scitranslmed.aal3604
Nano-Magnetic System For Rapid Diagnosis Of Acute Infection.
ACS Nano. 2017;11(11):11425-11432 - PMID: 29121461 - PMCID: PMC6296367 - DOI: 10.1021/acsnano.7b06074
Integrated Kidney Exosome Analysis (iKEA) For The Detection Of Kidney Transplant Rejection.
ACS Nano. 2017;11(11):11041-11046 - PMID: 29053921 - PMCID: PMC6237084 - DOI: 10.1021/acsnano.7b05083
Integrated Magneto-Chemical Sensor For On-Site Food Allergen Detection.
ACS Nano. 2017;11(10):10062-10069 - PMID: 28792732 - DOI: 10.1021/acsnano.7b04318
Transparent Electrophysiology Microelectrodes and Interconnects from Metal Nanomesh.
ACS Nano. 2017;11(4):4365-4372 - PMID: 28391679 - DOI: 10.1021/acsnano.7b01995
The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes.
Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer.
Imaging the pharmacology of nanomaterials by intravital microscopy: Towards understanding their biological behavior.
Adv Drug Deliv Rev. 2017;113:61-86 - PMID: 27266447 - PMCID: PMC5136524 - DOI: 10.1016/j.addr.2016.05.023
Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior
Adv Drug Deliv Rev. 2017;113:61-86 - PMID: 27266447 - PMCID: PMC5136524 - DOI: 10.1016/j.addr.2016.05.023
Imaging the emergence and natural progression of spontaneous autoimmune diabetes.
Proc Natl Acad Sci U S A. 2017;114(37):E7776-E7785 - PMID: 28839093 - PMCID: PMC5604023 - DOI: 10.1073/pnas.1707381114
Design and Development of Fluorescent Vemurafenib Analogs for In Vivo Imaging.
Prediction of Anti-cancer Nanotherapy Efficacy by Imaging
Measurement of drug-target engagement in live cells by two-photon fluorescence anisotropy imaging.
MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer.
Stem Cell Reports. 2017;8(6):1497-1505 - PMID: 28528698 - PMCID: PMC5470095 - DOI: 10.1016/j.stemcr.2017.04.024
Analyses of Intravesicular Exosomal Proteins Using a Nano-Plasmonic System
ACS Photonics. 2017;5(2):487-494 - PMID: 29805987 - PMCID: PMC5966285 - DOI: 10.1021/acsphotonics.7b00992
Integrated microHall magnetometer to measure the magnetic properties of nanoparticles.
Novel nanosensing technologies for exosome detection and profiling.
Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease
Facile silicification of plastic surface for bioassays.
Facile Coating Strategy to Functionalize Inorganic Nanoparticles for Biosensing
Bioconjug Chem. 2017;28(1):33-37 - PMID: 27792877 - PMCID: PMC5474933 - DOI: 10.1021/acs.bioconjchem.6b00524
Deletion of β-1 integrin in collecting duct principal cells leads to tubular injury and renal medullary fibrosis.
Am J Physiol Renal Physiol. 2017;313(4):F1026-F1037 - PMID: 28701310 - PMCID: PMC5668581 - DOI: 10.1152/ajprenal.00038.2017
Motion characterization scheme to minimize motion artifacts in intravital microscopy.
J Biomed Opt. 2017;22(3):36005 - PMID: 28253383 - PMCID: PMC5333764 - DOI: 10.1117/1.JBO.22.3.036005
Deep-learning based hologram classification for molecular diagnostics
bioRxiv. 2017;192559:ePub - DOI: 10.1101/192559
SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions
Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy
Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance.
Cancer Discov. 2016;6(4):382-99 - PMID: 26984351 - PMCID: PMC5087317 - DOI: 10.1158/2159-8290.CD-15-0933
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver
Supramolecular Metallo-Bioadhesive for Minimally Invasive Use
Real-time high dynamic range laser scanning microscopy.
Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging.
Imaging approaches to optimize molecular therapies
Sci Transl Med. 2016;8(355):355ps16 - PMID: 27605550 - DOI: 10.1126/scitranslmed.aaf3936
RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction
Integrated Magneto-Electrochemical Sensor for Exosome Analysis.
Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.
Circ Res. 2016;119(7):853-64 - PMID: 27444755 - PMCID: PMC5378496 - DOI: 10.1161/CIRCRESAHA.116.309001
Rapid identification of health care–associated infections with an integrated fluorescence anisotropy system
Quantitating drug-target engagement in single cells in vitro and in vivo.
Holographic Assessment of Lymphoma Tissue (HALT) for Global Oncology Field Applications
Point-of-Care Technologies for Precision Cardiovascular Care and Clinical Research: National Heart, Lung, and Blood Institute Working Group.
JACC Basic Transl Sci. 2016;1(1-2):73-86 - PMID: 26977455 - PMCID: PMC4787294 - DOI: 10.1016/j.jacbts.2016.01.008
Extracellular vesicles from high grade glioma exchange diverse pro-oncogenic signals that maintain intratumoral heterogeneity.
Cancer Res. 2016;76(10):2876-2881 - PMID: 27013191 - PMCID: PMC4873326 - DOI: 10.1158/0008-5472.CAN-15-3432
PF4 Promotes Platelet Production and Lung Cancer Growth.
Cell Rep. 2016;17(7):1764-1772 - PMID: 27829148 - PMCID: PMC5108525 - DOI: 10.1016/j.celrep.2016.10.031
Glucagon-like peptide-1 receptor activation attenuates platelet aggregation and thrombosis.
Diabetes. 2016;65(6):1714-23 - PMID: 26936963 - DOI: 10.2337/db15-1141
Point of care assessment of melanoma tumor signaling and metastatic burden from μNMR analysis of tumor fine needle aspirates and peripheral blood.
Nanomedicine. 2016;13(3):821-828 - PMID: 27993725 - PMCID: PMC5392428 - DOI: 10.1016/j.nano.2016.12.006
Digital diffraction detection of protein markers for avian influenza.
E-Selectin Inhibition Mitigates Splenic HSC Activation and Myelopoiesis in Hypercholesterolemic Mice With Myocardial Infarction.
Arterioscler Thromb Vasc Biol. 2016;36(9):1802-8 - PMID: 27470513 - PMCID: PMC5001901 - DOI: 10.1161/ATVBAHA.116.307519
Fluorescent vinblastine probes for live cell imaging
Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response
A magneto-DNA nanoparticle system for the rapid and sensitive diagnosis of enteric fever.
Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography.
Design of a microfluidic chip for magnetic-activated sorting of one-bead-one-compound libraries.
ACS Comb Sci. 2016;18(6):271-8 - PMID: 27124678 - PMCID: PMC5321554 - DOI: 10.1021/acscombsci.5b00180
Two-Photon Fluorescence Anisotropy Microscopy for Imaging and Direct Measurement of Intracellular Drug Target Engagement
IEEE J Sel Top Quant. 2016;22 (3):6801607 - PMID: 27440991 - PMCID: PMC4946648 - DOI: 10.1109/JSTQE.2015.2501384
Two-photon imaging of pancreatic beta cells in real time in vivo
Technology. 2016;4(2):130-134
Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis.
Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis.
Science. 2015;347(6227):1260-1265 - PMID: 25766237 - PMCID: PMC4376966 - DOI: 10.1126/science.aaa4268
Recent Developments in Magnetic Diagnostic Systems
Single-cell magnetic imaging using a quantum diamond microscope.
In vivo cell-cycle profiling in xenograft tumors by quantitative intravital microscopy
Nanotechnology.
JAMA. 2015;313(2):135-136 - PMID: 25585320 - DOI: 10.1001/jama.2014.16315
Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction.
Circulation. 2015;132(20):1880-90 - PMID: 26358260 - PMCID: PMC4651795 - DOI: 10.1161/CIRCULATIONAHA.115.016160
Response to Letter Regarding Article, "18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Enables the Detection of Recurrent Same-Site Deep Vein Thrombosis by Illuminating Recently Formed, Neutrophil-Rich Thrombus"
Circulation. 2015;131(24):e531-2 - PMID: 26078375 - DOI: 10.1161/CIRCULATIONAHA.115.014802
Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells
Cell Stem Cell. 2015;16 (5):477-487 - PMID: 25957903 - PMCID: PMC4426344 - DOI: 10.1016/j.stem.2015.04.008
Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug.
Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters.
Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma
Predicting therapeutic nano-medicine efficacy using a companion MR imaging nanoparticle.
Characterizing the Interactions of Organic Nanoparticles with Renal Epithelial Cells in Vivo.
Acoustic Purification of Extracellular Microvesicles.
Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis.
Circ Res. 2015;117(10):835-45 - PMID: 26394773 - PMCID: PMC4619168 - DOI: 10.1161/CIRCRESAHA.115.307024
Imaging Granzyme B Activity Assesses Immune-Mediated Myocarditis.
Circ Res. 2015;117(6):502-12 - PMID: 26199323 - PMCID: PMC4553143 - DOI: 10.1161/CIRCRESAHA.115.306364
Ischemic Stroke Activates Hematopoietic Bone Marrow Stem Cells.
Circ Res. 2015;116(3):407-17 - PMID: 25362208 - PMCID: PMC4312511 - DOI: 10.1161/CIRCRESAHA.116.305207
The use of (18)F-2-fluorodeoxyglucose (FDG) to label antibody fragments for immuno-PET of pancreatic cancer.
ACS Cent Sci. 2015;1(3):142-147 - PMID: 26955657 - PMCID: PMC4778250 - DOI: 10.1021/acscentsci.5b00121
Macrophages retain hematopoietic stem cells in the spleen via VCAM-1.
Advancing biomedical imaging
Proc Natl Acad Sci U S A. 2015;112(47):14424-8 - PMID: 26598657 - PMCID: PMC4664297 - DOI: 10.1073/pnas.1508524112
Noninvasive imaging of immune responses.
Proc Natl Acad Sci U S A. 2015;112(19):6146-51 - PMID: 25902531 - PMCID: PMC4434737 - DOI: 10.1073/pnas.1502609112
Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone
Proc Natl Acad Sci U S A. 2015;112(18):5613-8 - PMID: 25870273 - PMCID: PMC4426451 - DOI: 10.1073/pnas.1501815112
Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients
Proc Natl Acad Sci U S A. 2015;112(7):2139-44 - PMID: 25650428 - PMCID: PMC4343112 - DOI: 10.1073/pnas.1424993112
Population dynamics of islet-infiltrating cells in autoimmune diabetes.
Proc Natl Acad Sci U S A. 2015;112(5):1511-6 - PMID: 25605891 - PMCID: PMC4321317 - DOI: 10.1073/pnas.1423769112
On chip analysis of CNS lymphoma in cerebrospinal fluid.
Bioorthogonal Radiopaque Hydrogel for Endoscopic Delivery and Universal Tissue Marking.
Adv Healthc Mater. 2015;5(4):421-426 - PMID: 26688173 - PMCID: PMC4811597 - DOI: 10.1002/adhm.201500780
Imaging the beating heart in the mouse using intravital microscopy techniques.
Nat Protoc. 2015;10(11):1802-1819 - PMID: 26492138 - PMCID: PMC5380003 - DOI: 10.1038/nprot.2015.119
Bioorthogonal Click Chemistry-Based Synthetic Cell Glue.
Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages.
Circ Heart Fail. 2015;8(5):980-7 - PMID: 26232205 - PMCID: PMC4568849 - DOI: 10.1161/CIRCHEARTFAILURE.115.002334
Exploring alternative ovarian cancer biomarkers using innovative nanotechnology strategies.
Cancer Metastasis Rev. 2015;34(1):75-82 - PMID: 25543192 - PMCID: PMC5474936 - DOI: 10.1007/s10555-014-9546-9
Advances in measuring single-cell pharmacokinetics and pharmacology in vivo.
Drug Discov Today. 2015;20(9):1087-92 - PMID: 26024776 - PMCID: PMC4567932 - DOI: 10.1016/j.drudis.2015.05.011
Fluorescence polarization-based nucleic acid testing for rapid and cost-effective diagnosis of infectious disease
Bioorthogonal fluorophore linked DFO - Technology enabling facile chelator quantification and multimodal imaging of antibodies.
Bioconjug Chem. 2015;27(1):257-63 - PMID: 26684717 - PMCID: PMC4858350 - DOI: 10.1021/acs.bioconjchem.5b00630
Nanostar clustering improves the sensitivity of plasmonic assays.
Bioconjug Chem. 2015;26(8):1470-1474 - PMID: 26102604 - PMCID: PMC5292976 - DOI: 10.1021/acs.bioconjchem.5b00343
Optimized Near-IR fluorescent agents for in vivo imaging of Btk expression.
Bioconjug Chem. 2015;26(8):1513-1518 - PMID: 26017814 - PMCID: PMC4772718 - DOI: 10.1021/acs.bioconjchem.5b00152
Multimodal targeted high relaxivity thermosensitive liposome for in vivo imaging.
Rapid, high efficiency isolation of pancreatic ß-cells
Single cell resolution in vivo imaging of DNA damage following PARP inhibition
Nano-plasmonic exosome diagnostics.
Expert Rev Mol Diagn. 2015;15(6):725-33 - PMID: 25936957 - PMCID: PMC4675626 - DOI: 10.1586/14737159.2015.1041378
Tailoring Adjuvant Radiation Therapy by Intraoperative Imaging to Detect Residual Cancer.
Semin Radiat Oncol. 2015;25(4):313-21 - PMID: 26384279 - PMCID: PMC4575408 - DOI: 10.1016/j.semradonc.2015.05.005
New techniques for motion-artifact-free in vivo cardiac microscopy.
Nanoparticle Detection of Urinary Markers for Point-of-Care Diagnosis of Kidney Injury.
PLoS ONE. 2015;10(7):e0133417 - PMID: 26186708 - PMCID: PMC4506142 - DOI: 10.1371/journal.pone.0133417
Engineered Trehalose Permeable to Mammalian Cells.
PLoS ONE. 2015;10(6):e0130323 - PMID: 26115179 - PMCID: PMC4482662 - DOI: 10.1371/journal.pone.0130323
Statins Improve the Resolution of Established Murine Venous Thrombosis: Reductions in Thrombus Burden and Vein Wall Scarring.
PLoS ONE. 2015;10(2):e0116621 - PMID: 25680183 - PMCID: PMC4334538 - DOI: 10.1371/journal.pone.0116621
Photocleavable DNA Barcoding Antibodies for Multiplexed Protein Analysis in Single Cells.
Methods Mol Biol. 2015;1346:47-54 - PMID: 26542714 - DOI: 10.1007/978-1-4939-2987-0_4
Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor
Imaging macrophages with nanoparticles.
Nat Mater. 2014;13(2):125-38 - PMID: 24452356 - DOI: 10.1038/nmat3780
Silencing of CCR2 in myocarditis.
Eur Heart J. 2014;36(23):1478-88 - PMID: 24950695 - PMCID: PMC4465633 - DOI: 10.1093/eurheartj/ehu225
Chronic variable stress activates hematopoietic stem cells
FDG-PET/CT Enables the Detection of Recurrent Same-Site Deep Vein Thrombosis by Illuminating Recently Formed, Neutrophil-Rich Thrombus.
Circulation. 2014;130(13):1044-52 - PMID: 25070665 - PMCID: PMC4174982 - DOI: 10.1161/CIRCULATIONAHA.114.008902
Innate Response Activator B Cells Aggravate Atherosclerosis by Stimulating TH1 Adaptive Immunity.
Circulation. 2014;129(16):1677-87 - PMID: 24488984 - PMCID: PMC3997655 - DOI: 10.1161/CIRCULATIONAHA.113.006381
Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays.
In vivo imaging of specific drug-target binding at subcellular resolution.
Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin
Sci Transl Med. 2014;6 (261):261ra152 - PMID: 25378644 - PMCID: PMC4330962 - DOI: 10.1126/scitranslmed.3009318
Cancer Cell Profiling by Barcoding Allows Multiplexed Protein Analysis in Fine-Needle Aspirates
Sci Transl Med. 2014;6(219):219ra9 - PMID: 24431113 - PMCID: PMC4063286 - DOI: 10.1126/scitranslmed.3007361
Ultrafluorogenic Coumarin-Tetrazine Probes for Real-Time Biological Imaging.
Angew Chem Int Ed Engl. 2014;53(29):7531-4 - PMID: 24915832 - PMCID: PMC4122131 - DOI: 10.1002/anie.201403890
Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction.
Circ Res. 2014;115(2):284-95 - PMID: 24786973 - PMCID: PMC4082439 - DOI: 10.1161/CIRCRESAHA.115.303567
Ly-6Chigh Monocytes Depend on Nr4a1 to Balance both Inflammatory and Reparative Phases in the Infarcted Myocardium.
Circ Res. 2014;114(10):1611-22 - PMID: 24625784 - PMCID: PMC4017349 - DOI: 10.1161/CIRCRESAHA.114.303204
Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis.
Intravital imaging of cardiac function at the single-cell level.
Proc Natl Acad Sci U S A. 2014;111(31):11257-62 - PMID: 25053815 - PMCID: PMC4128110 - DOI: 10.1073/pnas.1401316111
Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature.
Proc Natl Acad Sci U S A. 2014;111(31):11419-24 - PMID: 25049388 - PMCID: PMC4128122 - DOI: 10.1073/pnas.1410854111
Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut.
Proc Natl Acad Sci U S A. 2014;111(18):6696-701 - PMID: 24753589 - PMCID: PMC4020091 - DOI: 10.1073/pnas.1405634111
Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer.
Clin Cancer Res. 2014;21(2):396-404 - PMID: 25348516 - PMCID: PMC4447091 - DOI: 10.1158/1078-0432.CCR-14-1591
Magnetic Ligation Method for Quantitative Detection of MicroRNAs.
Adv Healthc Mater. 2014;3(7):1015-9 - PMID: 24532323 - PMCID: PMC4107040 - DOI: 10.1002/adhm.201300672
Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells.
Magnetic sensing technology for molecular analyses.
Red Si-rhodamine drug conjugates enable imaging in GFP cells.
Increased Microvascularization and Vessel Permeability Associate with Active Inflammation in Human Atheromata.
Circ Cardiovasc Imaging. 2014;7(6):920-929 - PMID: 25170063 - PMCID: PMC4237630 - DOI: 10.1161/CIRCIMAGING.114.002113
Effect of Small Molecule Modification on Single Cell Pharmacokinetics of PARP Inhibitors.
Mol Cancer Ther. 2014;13(4):986-95 - PMID: 24552776 - PMCID: PMC3981972 - DOI: 10.1158/1535-7163.MCT-13-0801
Imaging cellular distribution of Bcl inhibitors using small molecule drug conjugates.
In Vivo Imaging of Multidrug Resistance Using a Third Generation MDR1 Inhibitor.
Single cell imaging of Bruton's tyrosine kinase using an irreversible inhibitor.
Automated motion artifact removal for intravital microscopy, without a priori information.
Pharmacokinetics of natural and engineered secreted factors delivered by mesenchymal stromal cells.
Steady state anisotropy two-photon microscopy resolves multiple, spectrally similar fluorophores, enabling in vivo multilabel imaging.
Advanced Motion Compensation Methods for Intravital Optical Microscopy.
IEEE J Sel Top Quant. 2014;20(2):ePub - PMID: 24273405 - PMCID: PMC3832946 - DOI: 10.1109/JSTQE.2013.2279314
Efficient Acid-Catalyzed (18) F/(19) F Fluoride Exchange of BODIPY Dyes.
Platinum Compounds for High-Resolution In Vivo Cancer Imaging.
Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid-Phase Peptide Synthesis.
Modelling and predicting the biological effects of nanomaterials.
SAR QSAR Environ Res. 2014;25(2):161-72 - PMID: 24625316 - DOI: 10.1080/1062936X.2013.874367
Imaging windows for long-term intravital imaging: general overview
Intravital. 2014;3:2: e29917
Angiotensin II Drives the Production of Tumor-Promoting Macrophages
Immunity. 2013;38(2):296-308 - PMID: 23333075 - PMCID: PMC3582771 - DOI: 10.1016/j.immuni.2012.10.015
A magneto-DNA nanoparticle system for rapid detection and phenotyping of bacteria
Local proliferation dominates lesional macrophage accumulation in atherosclerosis
Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice.
Circulation. 2013;127(20):2038-2046 - PMID: 23616627 - PMCID: PMC3661714 - DOI: 10.1161/CIRCULATIONAHA.112.000116
In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing.
J Am Coll Cardiol. 2013;63(15):1556-66 - PMID: 24361318 - PMCID: PMC3992176 - DOI: 10.1016/j.jacc.2013.11.023
Magnetic barcode assay for genetic detection of pathogens
Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.
Bioorthogonal Approach to Identify Unsuspected Drug Targets in Live Cells
Angew Chem Int Ed Engl. 2013;52(40):10593-7 - PMID: 23960025 - PMCID: PMC3856564 - DOI: 10.1002/anie.201304096
BODIPY-Tetrazine Derivatives as Superbright Bioorthogonal Turn-on Probes.
Angew Chem Int Ed Engl. 2013;52(27):6917-6920 - PMID: 23712730 - PMCID: PMC3875324 - DOI: 10.1002/anie.201301100
Magnetic Nanosensor for Detection and Profiling of Erythrocyte-Derived Microvesicles.
Polymeric Nanoparticle PET/MR Imaging Allows Macrophage Detection in Atherosclerotic Plaques.
Circ Res. 2013;112(5):755-61 - PMID: 23300273 - PMCID: PMC3586287 - DOI: 10.1161/CIRCRESAHA.111.300576
Ascites analysis by a microfluidic chip allows tumor-cell profiling
Proc Natl Acad Sci U S A. 2013;110(51):E4978-86 - PMID: 24297935 - PMCID: PMC3870756 - DOI: 10.1073/pnas.1315370110
Upconverting Organic Dye Doped Core-Shell Nano-Composites for Dual-Modality NIR Imaging and Photo-Thermal Therapy.
μHall Chip for Sensitive Detection of Bacteria
Adv Healthc Mater. 2013;2(9):1224-8 - PMID: 23495188 - PMCID: PMC4340655 - DOI: 10.1002/adhm.201200380
Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1.
Cancer Res. 2013;74(3):738-50 - PMID: 24310399 - PMCID: PMC3928601 - DOI: 10.1158/0008-5472.CAN-13-2650
Nano-SAR Development for Bioactivity of Nanoparticles with Considerations of Decision Boundaries.
Small. 2013;9(9-10):1842-52 - PMID: 23423856 - DOI: 10.1002/smll.201201903
Molecular characterization of scant lung tumor cells using iron-oxide nanoparticles and micro-nuclear magnetic resonance.
Nanomedicine. 2013;10 :661-668 - PMID: 24200523 - PMCID: PMC3966960 - DOI: 10.1016/j.nano.2013.10.008
Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells.
A photoactivatable drug–caged fluorophore conjugate allows direct quantification of intracellular drug transport
Nanoparticle PET-CT Detects Rejection and Immunomodulation in Cardiac Allografts.
Circ Cardiovasc Imaging. 2013;6(4):568-73 - PMID: 23771986 - PMCID: PMC3734553 - DOI: 10.1161/CIRCIMAGING.113.000481
A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels-Alder Click Chemistry.
J Nucl Med. 2013;54(8):1389-96 - PMID: 23708196 - PMCID: PMC4151562 - DOI: 10.2967/jnumed.112.115840
Targeting cathepsin e in pancreatic cancer by a small molecule allows in vivo detection.
Comparison of select cancer biomarkers in human circulating and bulk tumor cells using magnetic nanoparticles and miniaturized micro-NMR system.
Nanomedicine (Lond). 2013;9(7):1009-17 - PMID: 23570873 - PMCID: PMC4330975 - DOI: 10.1016/j.nano.2013.03.011
Fluorescence Endoscopy of Cathepsin Activity Discriminates Dysplasia from Colitis.
Inflamm Bowel Dis. 2013;19(7):1339-1345 - PMID: 23591598 - PMCID: PMC4306589 - DOI: 10.1097/MIB.0b013e318281f3f8
Fluorescent Exendin-4 Derivatives for Pancreatic β-Cell Analysis.
Bioorthogonal Small Molecule Imaging Agents Allow Single-Cell Imaging of MET
PLoS ONE. 2013;8 (11):e81275 - PMID: 24265843 - PMCID: PMC3827223 - DOI: 10.1371/journal.pone.0081275
Single Cell Analysis of Drug Distribution by Intravital Imaging.
Rare cell isolation and profiling on a hybrid magnetic/size-sorting chip
Sequential average segmented microscopy for high signal-to-noise ratio motion-artifact-free in vivo heart imaging.
Biomed Opt Express. 2013;4(10):2095-106 - PMID: 24156067 - PMCID: PMC3799669 - DOI: 10.1364/BOE.4.002095
Accurate prediction of nodal status in preoperative patients with pancreatic ductal adenocarcinoma using next-gen nanoparticle.
Microfluidic On-chip Capture-cycloaddition Reaction to Reversibly Immobilize Small Molecules or Multi-component Structures for Biosensor Applications.
Oxidation Kinetics and Magnetic Properties of Elemental Iron Nanoparticles
Part. Part. Syst. Charact. 2013;30:667–671 - PMID: 24077230 - PMCID: PMC3783348 - DOI: 10.1002/ppsc.201300013
Automated analysis of clonal cancer cells by intravital imaging.
Myocardial infarction accelerates atherosclerosis
The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism.
Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism.
Innate Response Activator B Cells Protect Against Microbial Sepsis
Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy
Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging.
PET/MRI of Inflammation in Myocardial Infarction
J Am Coll Cardiol. 2012;59:153-163 - PMID: 22222080 - PMCID: PMC3257823 - DOI: 10.1016/j.jacc.2011.08.066
Real-time in vivo imaging of the beating mouse heart at microscopic resolution
Ultrasensitive Clinical Enumeration of Rare Cells ex Vivo Using a Micro-Hall Detector
Sci Transl Med. 2012;4 (141):141ra92 - PMID: 22764208 - PMCID: PMC3603277 - DOI: 10.1126/scitranslmed.3003747
A Magnetic Gram Stain for Bacterial Detection.
Angew Chem Int Ed Engl. 2012;51(31):7752-5 - PMID: 22744868 - PMCID: PMC3496380 - DOI: 10.1002/anie.201202982
Bioorthogonal Imaging of Aurora Kinase A in Live Cells.
Angew Chem Int Ed Engl. 2012;51(27):6598-603 - PMID: 22644700 - PMCID: PMC3523717 - DOI: 10.1002/anie.201200994
Synthesis of [(18) F]BODIPY: Bifunctional Reporter for Hybrid Optical/Positron Emission Tomography Imaging.
Angew Chem Int Ed Engl. 2012;51(19):4603-6 - PMID: 22473535 - PMCID: PMC3343182 - DOI: 10.1002/anie.201107957
Photocleavable DNA barcode-antibody conjugates allow sensitive and multiplexed protein analysis in single cell.
J Am Chem Soc. 2012;134(45):18499-18502 - PMID: 23092113 - PMCID: PMC3498844 - DOI: 10.1021/ja307689w
Single Reporter for Targeted Multimodal in Vivo Imaging.
Mechanism of Magnetic Relaxation Switching Sensing.
Orthogonal Amplification of Nanoparticles for Improved Diagnostic Sensing.
Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis.
Selective Factor XIIa Inhibition Attenuates Silent Brain Ischemia: Application of Molecular Imaging Targeting Coagulation Pathway.
JACC Cardiovasc Imaging. 2012;5(11):1127-38 - PMID: 23153913 - PMCID: PMC3502014 - DOI: 10.1016/j.jcmg.2012.01.025
Molecular imaging of fibrin deposition in deep vein thrombosis using fibrin-targeted near-infrared fluorescence.
JACC Cardiovasc Imaging. 2012;5(6):607-15 - PMID: 22698530 - PMCID: PMC3376390 - DOI: 10.1016/j.jcmg.2012.01.017
Painting blood vessels and atherosclerotic plaques with an adhesive drug depot.
Proc Natl Acad Sci U S A. 2012;109(52):21444-9 - PMID: 23236189 - PMCID: PMC3535589 - DOI: 10.1073/pnas.1217972110
Origins of tumor-associated macrophages and neutrophils.
Proc Natl Acad Sci U S A. 2012;109(7):2491-6 - PMID: 22308361 - PMCID: PMC3289379 - DOI: 10.1073/pnas.1113744109
Implantable microenvironments to attract hematopoietic stem/cancer cells.
Proc Natl Acad Sci U S A. 2012;109(48):19638-43 - PMID: 23150542 - PMCID: PMC3511730 - DOI: 10.1073/pnas.1208384109
Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.
Proc Natl Acad Sci U S A. 2012;109(27):E1868-77 - PMID: 22699504 - PMCID: PMC3390871 - DOI: 10.1073/pnas.1116889109
Reactive polymer enables efficient in vivo bioorthogonal chemistry.
Proc Natl Acad Sci U S A. 2012;109(13):4762-7 - PMID: 22411831 - PMCID: PMC3324005 - DOI: 10.1073/pnas.1113466109
Modelling biological activities of nanoparticles.
Nano Lett. 2012;12(11):5808-5812 - PMID: 23039907 - DOI: 10.1021/nl303144k
Magnetic Nanoparticles and microNMR for Diagnostic Applications.
Cell Sorting: Microfluidic Cell Sorter (μFCS) for On-chip Capture and Analysis of Single Cells
Adv Healthc Mater. 2012;1(4):432-6 - PMID: 23184773 - PMCID: PMC3508764 - DOI: 10.1002/adhm.201200046
In vivo imaging of drug-induced mitochondrial outer membrane permeabilization at single cell resolution.
Cancer Res. 2012;72(12):2949-56 - PMID: 22505651 - PMCID: PMC3603290 - DOI: 10.1158/0008-5472.CAN-11-4096
Regulation of Monocyte Functional Heterogeneity by miR-146a and Relb
Demyelinating Diseases: Myeloperoxidase as an Imaging Biomarker and Therapeutic Target.
Dual Imaging and Photoactivated Nanoprobe for Controlled Cell Tracking.
Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells.
On-chip bioorthogonal chemistry enables immobilization of in situ modified nanoparticles and small molecules for label-free monitoring of protein binding and reaction kinetics.
Inflammation Modulates Murine Venous Thrombosis Resolution In Vivo: Assessment by Multimodal Fluorescence Molecular Imaging.
Arterioscler Thromb Vasc Biol. 2012;32(11):2616-24 - PMID: 22995524 - PMCID: PMC3516622 - DOI: 10.1161/ATVBAHA.112.251983
Sensitive and Direct Detection of Circulating Tumor Cells by Multimarker µ-Nuclear Magnetic Resonance.
Imaging Therapeutic PARP Inhibition In Vivo through Bioorthogonally Developed Companion Imaging Agents
Multifunctional nanoagent for thrombus-targeted fibrinolytic therapy.
Nanomedicine (Lond). 2012;7(7):1017-28 - PMID: 22348271 - PMCID: PMC3360120 - DOI: 10.2217/nnm.11.179
Optochemogenetics (OCG) allows more precise control of genetic engineering in mice with CreER regulators.
The neuropeptide neuromedin U promotes autoantibody-mediated arthritis.
Mapping molecular agents distributions in whole mice hearts using born-normalized optical projection tomography.
CT322, a VEGFR-2 antagonist, demonstrates anti-glioma efficacy in orthotopic brain tumor model as a single agent or in combination with temozolomide and radiation therapy.
J Neurooncol. 2012;110(1):37-48 - PMID: 22875706 - PMCID: PMC4291475 - DOI: 10.1007/s11060-012-0948-7
Noise suppressed, multifocus image fusion for enhanced intraoperative navigation.
Improved intravital microscopy via synchronization of respiration and holder stabilization.
J Biomed Opt. 2012;17(9):96018-1 - PMID: 23085919 - PMCID: PMC3449295 - DOI: 10.1117/1.JBO.17.9.096018
Establishment and characterization of a novel chordoma cell line: CH22.
J Orthop Res. 2012;30(10):1666-73 - PMID: 22504929 - DOI: 10.1002/jor.22113
Efficient (18)F-Labeling of Synthetic Exendin-4 Analogues for Imaging Beta Cells.
Motion compensation using a suctioning stabilizer for intravital microscopy
Intravital imaging.
Therapeutic siRNA silencing in inflammatory monocytes in mice
In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation
Extramedullary Hematopoiesis Generates Ly-6Chigh Monocytes that Infiltrate Atherosclerotic Lesions.
Circulation. 2011;125(2):364-74 - PMID: 22144566 - PMCID: PMC3263762 - DOI: 10.1161/CIRCULATIONAHA.111.061986
Report of the national heart, lung, and blood institute working group on the translation of cardiovascular molecular imaging.
Circulation. 2011;123(19):2157-63 - PMID: 21576680 - PMCID: PMC3119488 - DOI: 10.1161/CIRCULATIONAHA.110.000943
Multicore Assemblies Potentiate Magnetic Properties of Biomagnetic Nanoparticles.
Multiplexed Magnetic Labeling Amplification Using Oligonucleotide Hybridization.
Dextran-Coated Iron Oxide Nanoparticles: A Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy.
Biomedical Applications of Tetrazine Cycloadditions.
Two-dimensional intravascular near-infrared fluorescence molecular imaging of inflammation in atherosclerosis and stent-induced vascular injury.
J Am Coll Cardiol. 2011;57(25):2516-26 - PMID: 21679853 - PMCID: PMC3123768 - DOI: 10.1016/j.jacc.2011.02.036
Indocyanine Green Enables Near-Infrared Fluorescence Imaging of Lipid-Rich, Inflamed Atherosclerotic Plaques
Sci Transl Med. 2011;3 (84) ra45):84ra45 - PMID: 21613624 - PMCID: PMC3112179 - DOI: 10.1126/scitranslmed.3001577
Micro-NMR for Rapid Molecular Analysis of Human Tumor Samples
Sci Transl Med. 2011;3(71):71ra16 - PMID: 21346169 - PMCID: PMC3086073 - DOI: 10.1126/scitranslmed.3002048
Bioorthogonal Reaction Pairs Enable Simultaneous, Selective, Multi-Target Imaging.
Angew Chem Int Ed Engl. 2011;51(4):920-2 - PMID: 22162316 - PMCID: PMC3304098 - DOI: 10.1002/anie.201104389
Supramolecular Host-Guest Interaction for Labeling and Detection of Cellular Biomarkers.
Angew Chem Int Ed Engl. 2011;51(2):450-4 - PMID: 22113923 - PMCID: PMC3309171 - DOI: 10.1002/anie.201105670
Bioorthogonal Probes for Polo-like Kinase 1 Imaging and Quantification.
Angew Chem Int Ed Engl. 2011;50(40):9378-81 - PMID: 21948435 - PMCID: PMC3187564 - DOI: 10.1002/anie.201103273
Highly magnetic core-shell nanoparticles with a unique magnetization mechanism.
Angew Chem Int Ed Engl. 2011;50(20):4663-6 - PMID: 21495138 - PMCID: PMC3334859 - DOI: 10.1002/anie.201100101
Synthesis and In Vivo Imaging of a (18) F-Labeled PARP1 Inhibitor Using a Chemically Orthogonal Scavenger-Assisted High-Performance Method.
Angew Chem Int Ed Engl. 2011;50(8):1922-5 - PMID: 21328671 - PMCID: PMC3471140 - DOI: 10.1002/anie.201006579
Nanoparticle Mediated Measurement of Target-Drug Binding in Cancer Cells.
Ubiquitous Detection of Gram-Positive Bacteria with Bioorthogonal Magnetofluorescent Nanoparticles.
Probing Intracellular Biomarkers and Mediators of Cell Activation Using Nanosensors and Bioorthogonal Chemistry.
Accurate measurement of pancreatic islet {beta}-cell mass using a second-generation fluorescent exendin-4 analog.
Proc Natl Acad Sci U S A. 2011;108(31):12815-20 - PMID: 21768367 - PMCID: PMC3150928 - DOI: 10.1073/pnas.1109859108
Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging.
Clin Cancer Res. 2011;17(13):4484-93 - PMID: 21558403 - PMCID: PMC3131449 - DOI: 10.1158/1078-0432.CCR-11-0575
Analysis of Mitosis and Antimitotic Drug Responses in Tumors by In Vivo Microscopy and Single-Cell Pharmacodynamics.
Cancer Res. 2011;71(13):4608-16 - PMID: 21712408 - PMCID: PMC3129392 - DOI: 10.1158/0008-5472.CAN-11-0412
Vasculitis: Molecular Imaging by Targeting the Inflammatory Enzyme Myeloperoxidase.
Bevacizumab With Angiostatin-armed oHSV Increases Antiangiogenesis and Decreases Bevacizumab-induced Invasion in U87 Glioma.
In response to dr. Garbow and colleagues.
Int J Radiat Oncol Biol Phys. 2011;79(3):959 - PMID: 21281902
Miniature magnetic resonance system for point-of-care diagnostics.
Detection of Macrophages in Aortic Aneurysms by Nanoparticle Positron Emission Tomography-Computed Tomography.
Arterioscler Thromb Vasc Biol. 2011;31(4):750-7 - PMID: 21252070 - PMCID: PMC3060293 - DOI: 10.1161/ATVBAHA.110.221499
In Vivo PET-imaging of Histone Deacetylases by 18F-Suberoylanilide Hydroxamic Acid (18F-SAHA).
Molecular imaging of macrophage protease activity in cardiovascular inflammation in vivo.
Thromb Haemostasis. 2011;105(5):828-36 - PMID: 21225096 - PMCID: PMC3087830 - DOI: 10.1160/TH10-09-0589
Enhanced in Vivo Imaging of Metabolically Biotinylated Cell Surface Reporters.
Dragon (Repulsive Guidance Molecule b) Inhibits IL-6 Expression in Macrophages.
Interview: Nanomedicine in oncology: miniaturized means to an enormous end.
Nanomedicine (Lond). 2011;6(9):1495-8 - PMID: 22077461 - DOI: 10.2217/nnm.11.138
Facile Synthesis of Monofunctional Pentamethine Carbocyanine Fluorophores.
Dyes Pigm. 2011;90(2):119-122 - PMID: 21475610 - PMCID: PMC3070263 - DOI: 10.1016/j.dyepig.2010.12.008
Specific Pathogen Detection Using Bioorthogonal Chemistry and Diagnostic Magnetic Resonance.
89Zr Labeled Dextran Nanoparticles Enable in vivo Macrophage Imaging.
Synthesis and Evaluation of a Series of 1,2,4,5-Tetrazines for Bioorthogonal Conjugation.
A Modular Strategy for the Construction of Radiometallated Antibodies for Positron Emission Tomography Based on Inverse Electron Demand Diels-Alder Click Chemistry.
Different capacity of monocyte subsets to phagocytose iron-oxide nanoparticles.
PLoS ONE. 2011;6(10):e25197 - PMID: 21984904 - PMCID: PMC3184946 - DOI: 10.1371/journal.pone.0025197
A Systems Approach for Tumor Pharmacokinetics
In vivo tomographic imaging of red-shifted fluorescent proteins.
Biomed Opt Express. 2011;2(4):887-900 - PMID: 21483611 - PMCID: PMC3072128 - DOI: 10.1364/BOE.2.000887
High-Yielding, Two-Step (18) F Labeling Strategy for (18) F-PARP1 Inhibitors.
Palm NMR and 1-Chip NMR
IEEE J Solid-ST Circ. 2011;46(1):342-352
Quantitating Antibody Uptake In Vivo: Conditional Dependence on Antigen Expression Levels.
Mol Imaging Biol. 2011;13(4):623-32 - PMID: 20809210 - PMCID: PMC3000888 - DOI: 10.1007/s11307-010-0397-7
MRI with Magnetic Nanoparticles Monitors Downstream Anti-Angiogenic Effects of mTOR Inhibition.
Mol Imaging Biol. 2011;13(2):314-20 - PMID: 20559742 - DOI: 10.1007/s11307-010-0357-2
Intraoperative Near-infrared Fluorescent Cholangiography (NIRFC) in Mouse Models of Bile Duct Injury: Reply.
World J Surg. 2011;35(3):694-5 - PMID: 20645091 - DOI: 10.1007/s00268-010-0728-5
Molecular Detection of Biomarkers and Cells Using Magnetic Nanoparticles and Diagnostic Magnetic Resonance.
Methods Mol Biol. 2011;726:33-49 - PMID: 21424441 - DOI: 10.1007/978-1-61779-052-2_3
Development of Secreted Protein and Acidic and Rich in Cysteine (SPARC) Targeted Nanoparticles for the Prognostic Molecular Imaging of Metastatic Prostate Cancer
J Nanomedic Nanotechnol. 2011;2(4):112 - PMID: 22319675 - PMCID: PMC3273319 - DOI: 10.4172/2157-7439.1000112
Epigenetic memory in induced pluripotent stem cells.
The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1alpha.
Bone Marrow Stromal Cell Transplants Prevent Experimental Enterocolitis and Require Host CD11b+ Splenocytes.
Gastroenterology. 2010;140(3):966-975.e4 - PMID: 20955701 - PMCID: PMC3033974 - DOI: 10.1053/j.gastro.2010.10.013
Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection
Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation.
Eur Heart J. 2010;31(16):1975-84 - PMID: 20601388 - PMCID: PMC2921509 - DOI: 10.1093/eurheartj/ehq237
High-Resolution Magnetic Resonance Imaging Enhanced With Superparamagnetic Nanoparticles Measures Macrophage Burden in Atherosclerosis.
Circulation. 2010;122(17):1707-15 - PMID: 20937980 - PMCID: PMC3003265 - DOI: 10.1161/CIRCULATIONAHA.109.891804
Carboxymethylated Polyvinyl Alcohol Stabilizes Doped Ferrofluids for Biological Applications.
Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis.
J Am Coll Cardiol. 2010;55(15):1629-38 - PMID: 20378083 - PMCID: PMC2852892 - DOI: 10.1016/j.jacc.2009.08.089
Bioorthogonal Turn-On Probes for Imaging Small Molecules inside Living Cells.
Angew Chem Int Ed Engl. 2010;19 (49):2869-2872 - PMID: 20306505 - PMCID: PMC3433403 - DOI: 10.1002/anie.200906120
Activatable magnetic resonance imaging agents for myeloperoxidase sensing: mechanism of activation, stability, and toxicity.
Development of a Bioorthogonal and Highly Efficient Conjugation Method for Quantum Dots Using Tetrazine-Norbornene Cycloaddition.
Quantitative Nanostructure-Activity Relationship Modeling.
Angiotensin-Converting Enzyme Inhibition Prevents the Release of Monocytes From Their Splenic Reservoir in Mice With Myocardial Infarction.
Circ Res. 2010;107(11):1364-73 - PMID: 20930148 - PMCID: PMC2992104 - DOI: 10.1161/CIRCRESAHA.110.227454
In Vivo Imaging in Cancer.
Cold Spring Harb Perspect Biol. 2010;2(12):a003848 - PMID: 20861158 - PMCID: PMC2982169 - DOI: 10.1101/cshperspect.a003848
Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease.
Proc Natl Acad Sci U S A. 2010;107(11):5124-9 - PMID: 20194748 - PMCID: PMC2841922 - DOI: 10.1073/pnas.0911929107
Hybrid PET-optical imaging using targeted probes
Proc Natl Acad Sci U S A. 2010;107(17):7910-5 - PMID: 20385821 - PMCID: PMC2867879 - DOI: 10.1073/pnas.0915163107
Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients.
Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice.
The Phosphoinositide 3-Kinase Regulatory Subunit p85{alpha} Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling.
Cancer Res. 2010;70(13):5305-5315 - PMID: 20530665 - PMCID: PMC3204358 - DOI: 10.1158/0008-5472.CAN-09-3399
A Light-Activated Theranostic Nanoagent for Targeted Macrophage Ablation in Inflammatory Atherosclerosis.
Determining Multiple Aspects of Stem Cell-Based Therapies Using Novel Diagnostic and Therapeutic Multifunctional Molecules.
Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction.
Biomaterials . 2010;32(4):1102-9 - PMID: 21035182 - PMCID: PMC6805145 - DOI: 10.1016/j.biomaterials.2010.10.005
Human stem cells expressing novel TSP-1 variant have anti-angiogenic effect on brain tumors.
Imaging Primary Lung Cancers in Mice to Study Radiation Biology.
Int J Radiat Oncol Biol Phys. 2010;76(4):973-977 - PMID: 20206017 - PMCID: PMC2847457 - DOI: 10.1016/j.ijrobp.2009.11.038
WNT5A/JNK and FGF/MAPK Pathways Regulate the Cellular Events Shaping the Vertebrate Limb Bud.
Curr Top Dev Biol. 2010;20(22):1993-2002 - PMID: 21055947 - PMCID: PMC2998074 - DOI: 10.1016/j.cub.2010.09.063
Self-assembled magnetic filter for highly efficient immunomagnetic separation.
Targeted nanoagents for the detection of cancers.
Mol Oncol. 2010;4(6):511-28 - PMID: 20851695 - PMCID: PMC2981649 - DOI: 10.1016/j.molonc.2010.08.003
Pioglitazone Suppresses Inflammation In Vivo in Murine Carotid Atherosclerosis. Novel Detection by Dual-Target Fluorescence Molecular Imaging.
Arterioscler Thromb Vasc Biol. 2010;30(10):1933-9 - PMID: 20689078 - PMCID: PMC3030475 - DOI: 10.1161/ATVBAHA.110.206342
The Vascular Biology of Atherosclerosis and Imaging Targets.
J Nucl Med. 2010;51 Suppl 1:33S-37S - PMID: 20395349 - DOI: 10.2967/jnumed.109.069633
Near-Infrared Fluorescent Probe for Imaging of Pancreatic B Cells
Binding Affinity and Kinetic Analysis of Targeted Small Molecule-Modified Nanoparticles
Intravital Molecular Imaging of Small-Diameter Tissue-Engineered Vascular Grafts: A Feasibility Study.
Tissue Eng. 2010;16(4):597-607 - PMID: 19751103 - PMCID: PMC7875113 - DOI: 10.1089/ten.TEC.2009.0466
Rapid biocompatibility analysis of materials via in vivo fluorescence imaging of mouse models.
Bioorthogonal Small-Molecule Ligands for PARP1 Imaging in Living Cells.
Chembiochem. 2010;11(17):2374-2377 - PMID: 20967817 - PMCID: PMC3034378 - DOI: 10.1002/cbic.201000477
Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomography.
Block matching 3D random noise filtering for absorption optical projection tomography.
Phys Med Biol. 2010;55(18):5401-5415 - PMID: 20736500 - PMCID: PMC2934766 - DOI: 10.1088/0031-9155/55/18/009
Detection limits of intraoperative near infrared imaging for tumor resection.
Early identification of aortic valve sclerosis using iron oxide enhanced MRI.
J Magn Reson Imaging. 2010;31(1):110-6 - PMID: 20027578 - PMCID: PMC5638659 - DOI: 10.1002/jmri.22008
Magnetic nanoparticles for biomedical NMR-based diagnostics
Beilstein J Nanotechnol. 2010;1:142154 - PMID: 21977404 - PMCID: PMC3045933 - DOI: 10.3762/bjnano.1.17
Intraoperative Near-Infrared Fluorescent Cholangiography (NIRFC) in Mouse Models of Bile Duct Injury.
World J Surg. 2010;34 (2):336-343 - PMID: 20033407 - PMCID: PMC2809822 - DOI: 10.1007/s00268-009-0332-8
Molecular imaging of atherosclerosis: a progress report.
Tex Heart I J. 2010;37(3):324-7 - PMID: 20548813 - PMCID: PMC2879214
Magnetic nanoparticle biosensors.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010;2(3):291-304 - PMID: 20336708 - DOI: 10.1002/wnan.84
Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites
Enzyme-Sensitive Magnetic Resonance Imaging Targeting Myeloperoxidase Identifies Active Inflammation in Experimental Rabbit Atherosclerotic Plaques.
Circulation. 2009;120(7):592-9 - PMID: 19652086 - PMCID: PMC2736635 - DOI: 10.1161/CIRCULATIONAHA.108.813998
Molecular Imaging of Innate Immune Cell Function in Transplant Rejection.
Circulation. 2009;119(14):1925-32 - PMID: 19332470 - PMCID: PMC2676889 - DOI: 10.1161/CIRCULATIONAHA.108.796888
Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease.
Circulation. 2009;119(13):1785-94 - PMID: 19307473 - PMCID: PMC2717745 - DOI: 10.1161/CIRCULATIONAHA.108.827972
Fast and Sensitive Pretargeted Labeling of Cancer Cells through a Tetrazine/trans-Cyclooctene Cycloaddition.
Angew Chem Int Ed Engl. 2009;48(38):7013-6 - PMID: 19697389 - PMCID: PMC2790075 - DOI: 10.1002/anie.200903233
Ultrasensitive Detection of Bacteria Using Core-Shell Nanoparticles and an NMR-Filter System.
Angew Chem Int Ed Engl. 2009;48(31):5657-60 - PMID: 19554581 - PMCID: PMC2453069 - DOI: 10.1002/anie.200901791
Oxazine Conjugated Nanoparticle Detects in Vivo Hypochlorous Acid and Peroxynitrite Generation.
Supercritical-Fluid-Assisted One-Pot Synthesis of Biocompatible Core (γ-Fe2O3)/Shell(SiO2) Nanoparticles as High Relaxivity T2-Contrast Agents for Magnetic Resonance Imaging
Adv Funct Mater. 2009;19 :2319-2324
Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function.
Arthritis Rheumatol. 2009;60:2314-2324 - PMID: 19644878 - PMCID: PMC3080016 - DOI: 10.1002/art.24704
Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy.
Proc Natl Acad Sci U S A. 2009;106(12):4822-7 - PMID: 19264968 - PMCID: PMC2660771 - DOI: 10.1073/pnas.0806647106
Rapid detection and profiling of cancer cells in fine-needle aspirates.
Proc Natl Acad Sci U S A. 2009;106 (30):12459-12464 - PMID: 19620715 - PMCID: PMC2718371 - DOI: 10.1073/pnas.0902365106
Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.
Proc Natl Acad Sci U S A. 2009;106(8):2712-6 - PMID: 19196966 - PMCID: PMC2650331 - DOI: 10.1073/pnas.0813314106
Implantable diagnostic device for cancer monitoring.
Biosens Bioelectron. 2009;24(11):3252-7 - PMID: 19442510 - PMCID: PMC2738970 - DOI: 10.1016/j.bios.2009.04.010
Near-infrared fluorescence: application to in vivo molecular imaging.
Curr Opin Chem Biol. 2009;14:1-9 - PMID: 19879798 - DOI: 10.1016/j.cbpa.2009.09.029
Self-assembled Multifunctional Fe/MgO Nanospheres for Magnetic Resonance Imaging and Hyperthermia.
Nanomedicine. 2009;6(2):362-370 - PMID: 19800988 - DOI: 10.1016/j.nano.2009.09.003
Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma.
Int J Radiat Oncol Biol Phys. 2009;74(4):1207-16 - PMID: 19545786 - PMCID: PMC2733223 - DOI: 10.1016/j.ijrobp.2009.02.052
MRI of a Novel Murine Working Heart Transplant Model
Circ Heart Fail. 2009;2:272-274 - PMID: 19718275 - PMCID: PMC2733535 - DOI: 10.1161/CIRCHEARTFAILURE.109.852707
Heterogeneous In Vivo Behavior of Monocyte Subsets in Atherosclerosis.
Arterioscler Thromb Vasc Biol. 2009;29(10):1424-32 - PMID: 19372462 - PMCID: PMC2746262 - DOI: 10.1161/ATVBAHA.108.180521
Hybrid In Vivo FMT-CT Imaging of Protease Activity in Atherosclerosis With Customized Nanosensors.
Arterioscler Thromb Vasc Biol. 2009;29(10):1444-51 - PMID: 19608968 - PMCID: PMC2746251 - DOI: 10.1161/ATVBAHA.109.193086
Optical and Multimodality Molecular Imaging. Insights Into Atherosclerosis.
Arterioscler Thromb Vasc Biol. 2009;29(7):1017-24 - PMID: 19359659 - PMCID: PMC2733228 - DOI: 10.1161/ATVBAHA.108.165530
Upconverting luminescent nanomaterials: application to in vivo bioimaging.
A DNA-binding Gd chelate for the detection of cell death by MRI.
Nanoparticle-Target Interactions Parallel Antibody-Protein Interactions.
Molecular MRI Detects Low Levels of Cardiomyocyte Apoptosis in a Transgenic Model of Chronic Heart Failure.
Circ Cardiovasc Imaging. 2009;2(6):468-475 - PMID: 19920045 - PMCID: PMC2782621 - DOI: 10.1161/CIRCIMAGING.109.863779
Molecular MRI of Cardiomyocyte Apoptosis With Simultaneous Delayed-Enhancement MRI Distinguishes Apoptotic and Necrotic Myocytes In Vivo: Potential for Midmyocardial Salvage in Acute Ischemia.
Circ Cardiovasc Imaging. 2009;2(6):460-467 - PMID: 19920044 - PMCID: PMC2780438 - DOI: 10.1161/CIRCIMAGING.109.859678
Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle
Enhanced Antitumor Efficacy of Vasculostatin (Vstat120) Expressing Oncolytic HSV-1.
The antiproliferative cytostatic effects of a self-activating viridin prodrug.
Mol Cancer Ther. 2009;8(6):1666-1675 - PMID: 19509266 - PMCID: PMC2740925 - DOI: 10.1158/1535-7163.MCT-08-1012
Mutant Sodium Channel for Tumor Therapy.
Multimodal Nanoagents for the Detection of Intravascular Thrombi.
A Wortmannin-Cetuximab as a Double Drug.
A Multifunctional Single-Attachment-Point Reagent for Controlled Protein Biotinylation.
(18)F Labeled Nanoparticles for in Vivo PET-CT Imaging.
Improved detection of ovarian cancer metastases by intraoperative quantitative fluorescence protease imaging in a pre-clinical model.
Gynecol Oncol. 2009;112(3):616-22 - PMID: 19135233 - PMCID: PMC2664404 - DOI: 10.1016/j.ygyno.2008.11.018
A screening paradigm for the design of improved polymer-coated superparamagnetic iron oxide nanoparticles
J Mater Chem. 2009;19:6387-6392
Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries.
Synthesis and Photophysical Properties of Sulfonamidophenyl Porphyrins as Models for Activatable Photosensitizers.
Multicolor Fluorescent Intravital Live Microscopy (FILM) for Surgical Tumor Resection in a Mouse Xenograft Model.
Monocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensors.
High-yielding syntheses of hydrophilic conjugatable chlorins and bacteriochlorins.
High throughput transmission optical projection tomography using low cost graphics processing unit
Opt Express. 2009;17(25):22320-22332 - PMID: 20052155 - PMCID: PMC2805020 - DOI: 10.1364/OE.17.022320
Diffractionless beam in free space with adiabatic changing refractive index in a single mode tapered slab waveguide.
Transillumination fluorescence imaging in mice using biocompatible upconverting nanoparticles
Normalized Born ratio for fluorescence optical projection tomography.
On the dual contrast enhancement mechanism in frequency-selective inversion-recovery magnetic resonance angiography (IRON-MRA).
Genetically engineered T cells to target EGFRvIII expressing glioblastoma.
J Neuro-Oncol. 2009;94(3):373-82 - PMID: 19387557 - PMCID: PMC2730985 - DOI: 10.1007/s11060-009-9889-1
CMOS RF Biosensor Utilizing Nuclear Magnetic Resonance
IEEE J Solid-ST Circ. 2009;44:1629-1643
Enhancing navigation in biomedical databases by community voting and database-driven text classification.
BMC Bioinformatics. 2009;10(1):317 - PMID: 19799796 - PMCID: PMC2768718 - DOI: 10.1186/1471-2105-10-317
Nuclear Microscopy: A Novel Technique for Quantitative Imaging of Gadolinium Distribution within Tissue Sections.
Microsc Micoranal. 2009;15:338-44 - PMID: 19575834 - PMCID: PMC2802450 - DOI: 10.1017/S1431927609090813
A stabilized demethoxyviridin derivative inhibits PI3 kinase.
Bioorg Med Chem Lett. 2009;19(15):4223-7 - PMID: 19523825 - PMCID: PMC2877487 - DOI: 10.1016/j.bmcl.2009.05.105
Mesoscopic fluorescence tomography for in-vivo imaging of developing Drosophila.
Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging
Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy.
Clin Imaging. 2009;33(4):301-5 - PMID: 19559353 - DOI: 10.1016/j.clinimag.2009.01.013
18F-4V for PET-CT Imaging of VCAM-1 Expression in Atherosclerosis
J Am Coll Cardiol Img. 2009;2:1213-1222 - PMID: 19833312 - PMCID: PMC2773129 - DOI: 10.1016/j.jcmg.2009.04.016
Imaging in the era of molecular oncology
A secreted luciferase for ex vivo monitoring of in vivo processes.
Transglutaminase activity in acute infarcts predicts healing outcome and let ventricular remodelling : implications for FXIII therapy and antithrombin use in myocardial infarction
Eur Heart J. 2008;29:445-454 - PMID: 18276618 - DOI: 10.1093/eurheartj/ehm558
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.
Chip-NMR biosensor for detection and molecular analysis of cells.
Real-Time Catheter Molecular Sensing of Inflammation in Proteolytically Active Atherosclerosis.
Circulation. 2008;118(18):1802-9 - PMID: 18852366 - PMCID: PMC2729441 - DOI: 10.1161/CIRCULATIONAHA.108.785881
Activatable Magnetic Resonance Imaging Agent Reports Myeloperoxidase Activity in Healing Infarcts and Noninvasively Detects the Antiinflammatory Effects of Atorvastatin on Ischemia-Reperfusion Injury.
Circulation. 2008;117(9):1153-60 - PMID: 18268141 - PMCID: PMC2673051 - DOI: 10.1161/CIRCULATIONAHA.107.756510
Noninvasive in vivo imaging of monocyte trafficking to atherosclerotic lesions.
Circulation. 2008;117:388-395 - PMID: 18172031 - PMCID: PMC2705289 - DOI: 10.1161/CIRCULATIONAHA.107.719765
miR-296 Regulates Growth Factor Receptor Overexpression in Angiogenic Endothelial Cells.
Cancer Cell. 2008;14(5):382-393 - PMID: 18977327 - PMCID: PMC2597164 - DOI: 10.1016/j.ccr.2008.10.005
Noninvasive detection of macrophage-rich atherosclerotic plaque in hyperlipidemic rabbits using positive contrast magnetic resonance imaging.
J Am Coll Cardiol. 2008;52:483-91 - PMID: 18672170 - PMCID: PMC2628468 - DOI: 10.1016/j.jacc.2008.03.063
Sensitive NMR Sensors Detect Antibodies to Influenza.
Angew Chem Int Ed Engl. 2008;47(22):4119-4121 - PMID: 18428168 - PMCID: PMC2668198 - DOI: 10.1002/anie.200800069
Targeted Nanoparticles for Imaging Incipient Pancreatic Ductal Adenocarcinoma.
Multifunctional magnetic nanoparticles for targeted imaging and therapy.
Adv Drug Deliv Rev. 2008;60:1241-1251 - PMID: 18508157 - PMCID: PMC2583936 - DOI: 10.1016/j.addr.2008.03.014
Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo.
Proc Natl Acad Sci U S A. 2008;105(49)::19126-19131 - PMID: 19015534 - PMCID: PMC2614726 - DOI: 10.1073/pnas.0804798105
Tracking the Inflammatory Response in Stroke in Vivo by Sensing the Enzyme Myeloperoxidase
Proc Natl Acad Sci U S A. 2008;105 (47):18584-18589 - PMID: 19011099 - PMCID: PMC2587593 - DOI: 10.1073/pnas.0803945105
Perturbational profiling of nanomaterial biologic activity.
Proc Natl Acad Sci U S A. 2008;105:7387-7392 - PMID: 18492802 - PMCID: PMC2396702 - DOI: 10.1073/pnas.0802878105
Regression of drug-resistant lung cancer by the combination of rosiglitazone and Carboplatin.
Clin Cancer Res. 2008;14(20):6478-86 - PMID: 18927287 - PMCID: PMC2696122 - DOI: 10.1158/1078-0432.CCR-08-1128
Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation
Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis.
Detection of early prostate cancer using a hepsin-targeted imaging agent.
Cancer Res. 2008;68(7):2286-91 - PMID: 18381435 - PMCID: PMC2709884 - DOI: 10.1158/0008-5472.CAN-07-1349
Off-Resonance Angiography: A New Method to Depict Vessels--Phantom and Rabbit Studies.
Radiology. 2008;249(2)::501-509 - PMID: 18780823 - PMCID: PMC2657865 - DOI: 10.1148/radiol.2491071706
Human Breast Cancer Tumor Models: Molecular Imaging of Drug Susceptibility and Dosing during HER2/neu-targeted Therapy.
Bimodal viral vectors and in vivo imaging reveal the fate of human neural stem cells in experimental glioma model.
J Neurosci. 2008;28:4406-13 - PMID: 18434519 - PMCID: PMC3021321 - DOI: 10.1523/JNEUROSCI.0296-08.2008
Simplified syntheses of complex multifunctional nanomaterials.
Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy.
Neuroimage. 2008;45(2):360-9 - PMID: 19154791 - PMCID: PMC2707831 - DOI: 10.1016/j.neuroimage.2008.12.022
Slow Self-Activation Enhances The Potency of Viridin Prodrugs.
Targeted imaging of myocardial damage.
Nat Clin Pract Card. 2008;5 Suppl 2:S63-70 - PMID: 18641609 - PMCID: PMC2597275 - DOI: 10.1038/ncpcardio1115
MR-optical imaging of cardiovascular molecular targets.
Basic Res Cardiol. 2008;103:87-94 - PMID: 18324364 - PMCID: PMC2664635 - DOI: 10.1007/s00395-008-0707-2
Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications.
Basic Res Cardiol. 2008;103(2):122-30 - PMID: 18324368 - PMCID: PMC2597271 - DOI: 10.1007/s00395-008-0710-7
Integrated nanosensors to determine levels and functional activity of human telomerase.
Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and Temozolomide.
Mol Cancer Ther. 2008;7(11):3575-85 - PMID: 19001440 - PMCID: PMC2748233 - DOI: 10.1158/1535-7163.MCT-08-0640
Monofunctional Carbocyanine Dyes for Bio- and Bioorthogonal Conjugation.
Bioconjug Chem. 2008;19(12): :2487-2491 - PMID: 19053316 - PMCID: PMC2656649 - DOI: 10.1021/bc800417b
Tetrazine-Based Cycloadditions: Application to Pretargeted Live Cell Imaging.
Near Infrared Fluorescence-Based Bacteriophage Particles for Ratiometric pH Imaging.
Noninvasive imaging of apoptosis in cardiovascular disease.
Heart Fail Rev. 2008;13(2)::163-173 - PMID: 18074226 - PMCID: PMC2597223 - DOI: 10.1007/s10741-007-9068-4
Non-invasive optical detection of cathepsin K-mediated fluorescence reveals osteoclast activity in vitro and in vivo.
Electrode Chemistry Yields a Nanoparticle-Based NMR Sensor for Calcium.
BRAF activation initiates but does not maintain invasive prostate adenocarcinoma.
Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth.
A Novel Method of Imaging Calcium Urolithiasis Using Fluorescence.
J Urolology. 2008;179:1610-1614 - PMID: 18295253 - DOI: 10.1016/j.juro.2007.11.100
Design and demonstration of a small-animal up-conversion imager.
Impact of field strength and iron oxide nanoparticle concentration on the linearity and diagnostic accuracy of off-resonance imaging.
Magnetic microparticle aggregation for viscosity determination by MR.
Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft model.
In vivo quantitative microvasculature phenotype imaging of healthy and malignant tissues using a fiber-optic confocal laser microprobe.
Development of a Time Domain Fluorimeter for Fluorescent Lifetime Multiplexing Analysis.
IEEE T Biomed Circuits Syst. 2008;2(3):204-211 - PMID: 19830273 - PMCID: PMC2760943 - DOI: 10.1109/TBCAS.2008.2003195
Positive contrast MR-lymphography using inversion recovery with ON-resonant water suppression (IRON).
J Magn Reson Imaging. 2008;27(5):1175-1180 - PMID: 18425827 - PMCID: PMC2740932 - DOI: 10.1002/jmri.21337
Pilot Study Evaluating Use of Lymphotrophic Nanoparticle-Enhanced Magnetic Resonance Imaging for Assessing Lymph Nodes in Renal Cell Cancer.
Urology. 2008;71(4):708-12 - PMID: 18295316 - DOI: 10.1016/j.urology.2007.11.096
Notch signaling in cardiovascular disease and calcification.
Curr Cardiol Review. 2008;4(3):148-56 - PMID: 19936191 - PMCID: PMC2780816 - DOI: 10.2174/157340308785160552
Development of a Time Domain Fluorimeter (TDF) for Fluorescent Lifetime Multiplexing Analysis
2008;3:204-211
Restoration of p53 function leads to tumour regression in vivo.
Nature. 2007;445:661-5 - PMID: 17251932 - DOI: 10.1038/nature05541
A spatially and temporally restricted mouse model of soft tissue sarcoma.
Nature Med. 2007;13(8):992-997 - PMID: 17676052 - DOI: 10.1038/nm1602
Molecular imaging of cardiovascular disease.
Circulation. 2007;116(9):1052-61 - PMID: 17724271 - DOI: 10.1161/CIRCULATIONAHA.106.647164
Molecular magnetic resonance imaging in cardiovascular medicine.
Circulation. 2007;115(15):2076-86 - PMID: 17438163 - DOI: 10.1161/CIRCULATIONAHA.106.658930
Fluorescence Tomography and Magnetic Resonance Imaging of Myocardial Macrophage Infiltration in Infarcted Myocardium In Vivo.
Circulation. 2007;115:1384-1391 - PMID: 17339546 - DOI: 10.1161/CIRCULATIONAHA.106.663351
Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo.
Circulation. 2007;116(24):2841-50 - PMID: 18040026 - DOI: 10.1161/CIRCULATIONAHA.107.732867
Multimodality Molecular Imaging Identifies Proteolytic and Osteogenic Activities in Early Aortic Valve Disease.
Circulation. 2007;115:377-386 - PMID: 17224478 - DOI: 10.1161/CIRCULATIONAHA.106.654913
Optical Visualization of Cathepsin K Activity in Atherosclerosis With a Novel, Protease-Activatable Fluorescence Sensor.
Circulation. 2007;115(17):2292-8 - PMID: 17420353 - DOI: 10.1161/CIRCULATIONAHA.106.660340
Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis
Circulation. 2007;117:379-387 - PMID: 18158358 - PMCID: PMC2663426 - DOI: 10.1161/CIRCULATIONAHA.107.741181
Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct
Circ Res. 2007;100:1218-1225 - PMID: 17379832 - DOI: 10.1161/01.RES.0000265064.46075.31
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions.
Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk
Mast cells are an essential hematopoietic component for polyp development.
Proc Natl Acad Sci U S A. 2007;104:19977-82 - PMID: 18077429 - PMCID: PMC2148408 - DOI: 10.1073/pnas.0704620104
In vivo imaging of T cell delivery to tumors after adoptive transfer therapy
Proc Natl Acad Sci U S A. 2007;104:12457-12461 - PMID: 17640914 - PMCID: PMC1941490 - DOI: 10.1073/pnas.0704460104
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata
Effect of Tumor Microenvironment Modulation on the Efficacy of Oncolytic Virus Therapy
J Natl Cancer Inst. 2007;(99) 23:1768-1781 - PMID: 18042934 - DOI: 10.1093/jnci/djm229
Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses.
Cancer Res. 2007;67(19):9398-406 - PMID: 17909049 - PMCID: PMC2850558 - DOI: 10.1158/0008-5472.CAN-07-1063
MicroRNA-21 Knockdown Disrupts Glioma Growth In vivo and Displays Synergistic Cytotoxicity with Neural Precursor Cell Delivered S-TRAIL in Human Gliomas.
Cancer Res. 2007;67(19):8994-9000 - PMID: 17908999 - DOI: 10.1158/0008-5472.CAN-07-1045
Visualizing the dynamics of EGFR activity and antiglioma therapies in vivo
Cancer Res. 2007;67 (15):7335-7342 - PMID: 17671203 - DOI: 10.1158/0008-5472.CAN-07-0077
Colonic Adenocarcinomas: Near-Infrared Microcatheter Imaging of Smart Probes for Early Detection.
Radiology. 2007;244(1):232-8 - PMID: 17507718 - DOI: 10.1148/radiol.2441052114
Tomographic fluorescence imaging of tumor vascular volume in mice.
Radiology. 2007;242 (3):751-758 - PMID: 17325064 - DOI: 10.1148/radiol.2423052065
Quantitative Real-time Catheter-based Fluorescence Molecular Imaging in Mice.
Radiology. 2007;245(2):523-31 - PMID: 17940307 - DOI: 10.1148/radiol.2452061613
Targeted delivery of multifunctional magnetic nanoparticles
Nanomedicine. 2007;2(2):153-167 - PMID: 17716118 - DOI: 10.2217/17435889.2.2.153
Emerging concepts in molecular MRI.
Curr Opin Biotech. 2007;18(1):4-10 - PMID: 17126545 - DOI: 10.1016/j.copbio.2006.11.001
Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis.
Arth Rheum/AR C Res. 2007;56(1):117-128 - PMID: 17195214 - DOI: 10.1002/art.22303
A Highly Selective Fluorescent Probe for Thiol Bioimaging.
Org Lett. 2007;10 :37-40 - PMID: 18062694 - DOI: 10.1021/ol702539v
Sugar sensing based on induced pH changes
Chem Commun. 2007;(22):2299-2301 - PMID: 17534523 - DOI: 10.1039/b700741h
Optimized pH-responsive cyanine fluorochromes for detection of acidic environments
Chem Commun. 2007;(26):2747-9 - PMID: 17594041 - DOI: 10.1039/b703764c
Multiparameter noninvasive assessment of treatment susceptibility, drug target inhibition and tumor response guides cancer treatment.
Int J Cancer. 2007;(121) 11:2492-2500 - PMID: 17683072 - DOI: 10.1002/ijc.22995
A fluorescent probe for the detection of myeloperoxidase activity in atherosclerosis-associated macrophages.
Chem Biol. 2007;14:1221-31 - PMID: 18022561 - PMCID: PMC2785040 - DOI: 10.1016/j.chembiol.2007.10.005
Covalent Reactions of Wortmannin under Physiological Conditions.
Chem Biol. 2007;14(3):321-8 - PMID: 17379147 - DOI: 10.1016/j.chembiol.2007.02.007
Non-Invasive Optical Detection of Bone Mineral.
J Bone Miner Res. 2007;(22) 8:1208-1216 - PMID: 17488196 - DOI: 10.1359/jbmr.070504
Multiparameter Magnetic Relaxation Switch Assays.
Anal Chem. 2007;(79) 23:8863-9 - PMID: 17983206 - DOI: 10.1021/ac701976p
Utility of a New Bolus-Injectable Nanoparticle for Clinical Cancer Staging
Tumor Therapy Mediated by Lentiviral Expression of shBcl-2 and S-TRAIL.
Fate of a Bioactive Fluorescent Wortmannin Derivative in Cells.
Bioconjug Chem. 2007;19:130-137 - PMID: 17988080 - DOI: 10.1021/bc7002204
Protease-Sensitive Fluorescent Nanofibers.
Bioconjug Chem. 2007;(18) 6 ::1701-1704 - PMID: 17915958 - PMCID: PMC2528070 - DOI: 10.1021/bc070054z
A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses.
Novel Peptide Sequence ("IQ-tag") with High Affinity for NIR Fluorochromes Allows Protein and Cell Specific Labeling for In Vivo Imaging.
A Self-Immolative Reporter For beta-Galactosidase Sensing.
Chembiochem. 2007;8:560-566 - PMID: 17300128 - DOI: 10.1002/cbic.200600386
High Resolution Imaging of Murine Myocardial Infarction With Delayed Enhancement Cine Micro-CT.
Am J Physiol-Heart C. 2007;292(6):3172-8 - PMID: 17322414 - PMCID: PMC2680216 - DOI: 10.1152/ajpheart.01307.2006
Improved in vivo whole-animal detection limits of green fluorescent protein-expressing tumor lines by spectral fluorescence imaging.
Mol Imaging. 2007;6(4):269-76 - PMID: 17711782
Real-time multichannel imaging framework for endoscopy, catheters, and fixed geometry intraoperative systems.
Mol Imaging. 2007;6(3):147-55 - PMID: 17532881
Cell internalization of magnetic nanoparticles using transfection agents.
Mol Imaging. 2007;(6) 1:1-9 - PMID: 17311760
Model Systems for Fluorescence and Singlet Oxygen Quenching by Metalloporphyrins.
ChemMedChem. 2007;2:360-365 - PMID: 17245681 - DOI: 10.1002/cmdc.200600244
PepBank - a database of peptides based on sequence text mining and public peptide data sources.
BMC Bioinformatics. 2007;8(1):280 - PMID: 17678535 - PMCID: PMC1976427 - DOI: 10.1186/1471-2105-8-280
One-Pot Synthesis of New Symmetric and Asymmetric Xanthene Dyes.
Tetrahedron Lett. 2007;48(25):4383-4385 - PMID: 19834587 - PMCID: PMC2761723 - DOI: 10.1016/j.tetlet.2007.04.088
Membrane permeable esterase-activated fluorescent imaging probe.
Bioorg Med Chem Lett. 2007;17(18):5054-7 - PMID: 17664067 - PMCID: PMC1995663 - DOI: 10.1016/j.bmcl.2007.07.026
Molecular imaging -a new emphasis in radiology
Radiologe. 2007;47(1):6-7 - PMID: 17136404 - DOI: 10.1007/s00117-006-1447-7
Cell tracking : Principles and applications.
Radiologe. 2007;47(1):25-33 - PMID: 17187264 - DOI: 10.1007/s00117-006-1449-5
Advances in cardiovascular medicine through molecular imaging.
Radiologe. 2007;47(1):18-24 - PMID: 17187263 - DOI: 10.1007/s00117-006-1450-z
Molecular Imaging in Cancer
Science. 2006;312:1168-1171 - PMID: 16728630 - DOI: 10.1126/science.1125949
Metabolic Biotinylation of Cell Surface Receptors for in vivo Imaging
Nat Methods. 2006;3(5):391-396 - PMID: 16628210 - DOI: 10.1038/nmeth875
Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
Immunity. 2006;25(1):129-41 - PMID: 16860762 - DOI: 10.1016/j.immuni.2006.04.015
An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles.
Nat Mater. 2006;5(2):118-22 - PMID: 16444262 - DOI: 10.1038/nmat1571
Noninvasive Vascular Cell Adhesion Molecule-1 Imaging Identifies Inflammatory Activation of Cells in Atherosclerosis.
Circulation. 2006;114:1504-1511 - PMID: 17000904 - DOI: 10.1161/CIRCULATIONAHA.106.646380
Inflammation in Atherosclerosis. Visualizing Matrix Metalloproteinase Action in Macrophages In Vivo.
Circulation. 2006;114:55-62 - PMID: 16801460 - DOI: 10.1161/CIRCULATIONAHA.106.619056
Factor XIII Deficiency Causes Cardiac Rupture, Impairs Wound Healing, and Aggravates Cardiac Remodeling in Mice with Myocardial Infarction
Circulation. 2006;113(9):1196-1202 - PMID: 16505171 - PMCID: PMC4066325 - DOI: 10.1161/CIRCULATIONAHA.105.602094
Particularities of the vasculature can promote the organ specificity of autoimmune attack.
Nat Immunol. 2006;7(3):284-92 - PMID: 16444258 - DOI: 10.1038/ni1306
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies.
Cancer Cell. 2006;9(6):485-95 - PMID: 16730237 - DOI: 10.1016/j.ccr.2006.04.022
Molecular and Cellular Imaging of Atherosclerosis, Emerging Applications
J Am Coll Cardiol. 2006;47:1328-1338 - PMID: 16580517 - DOI: 10.1016/j.jacc.2006.01.029
Identification of the target self-antigens in reperfusion injury.
Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses
Proc Natl Acad Sci U S A. 2006;103:12873-12878 - PMID: 16908838 - PMCID: PMC1568940 - DOI: 10.1073/pnas.0605496103
Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease.
Proc Natl Acad Sci U S A. 2006;103(27):10340-5 - PMID: 16801531 - PMCID: PMC1502459 - DOI: 10.1073/pnas.0604260103
Both p16Ink4a and the p19Arf-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.
Proc Natl Acad Sci U S A. 2006;103:5947-5952 - PMID: 16585505 - PMCID: PMC1458678 - DOI: 10.1073/pnas.0601273103
A Fluorescent Nanosensor for Apoptotic Cells
Nano Lett. 2006;6 (3):488-490 - PMID: 16522048 - DOI: 10.1021/nl0524694
Selective antitumor effect of novel protease-mediated photodynamic agent
Cancer Res. 2006;66 (14):7225-7229 - PMID: 16849570 - DOI: 10.1158/0008-5472.CAN-06-0448
Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles
Nat Protoc. 2006;1(1):73-79 - PMID: 17406214 - DOI: 10.1038/nprot.2006.11
Neural Stem Cell Transplant Survival in Brains of Mice: Assessing the Effect of Immunity and Ischemia by using Real-time Bioluminescent Imaging.
Radiology. 2006;241(3):822-830 - PMID: 17114629 - DOI: 10.1148/radiol.2413050466
Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates
Radiology. 2006;240 (2):473-81 - PMID: 16864673 - DOI: 10.1148/radiol.2402050994
Continuous Analyte Sensing with Magnetic Nanoswitches
Small. 2006;(2) 10:1144-1147 - PMID: 17193579 - DOI: 10.1002/smll.200600204
A Macrophage Targeted Theranostic Nanoparticle for Biomedical Applications
Small. 2006;2(8-9):983-987 - PMID: 17193154 - DOI: 10.1002/smll.200600139
Cyclophosphamide Increases Transgene Expression Mediated by an Oncolytic Adenovirus in Glioma-Bearing Mice Monitored by Bioluminescence Imaging.
Multivalent effects of RGD peptides obtained by nanoparticle display
J Med Chem. 2006;49(20):6087-6093
Enzyme-targeted fluorescent imaging probes on a multiple antigenic peptide core
J Med Chem. 2006;49(15):4715-20 - PMID: 16854078 - DOI: 10.1021/jm051001a
Wortmannin-C20 Conjugates Generate Wortmannin.
J Med Chem. 2006;49(2):740-747 - PMID: 16420059 - DOI: 10.1021/jm050699p
Near infrared thoracoscopy of tumoral protease activity for improved detection of peripheral lung cancer.
Int J Cancer. 2006;118(11):2672-7 - PMID: 16380983 - DOI: 10.1002/ijc.21713
Peptide-based Biomaterials for Protease-Enhanced Drug Delivery
Biomacromolecules. 2006;7(4):1261-1265 - PMID: 16602747 - DOI: 10.1021/bm050920f
In vivo imaging of molecularly targeted phage
Neoplasia. 2006;8 (12):1011-1018
In vivo selection of phage for the optical imaging of PC-3 human prostate carcinoma in mice.
Nanoparticle Imaging of Integrins on Tumor Cells
Fluorescent Nanoparticle Uptake for Brain Tumor Visualization
A Mitochondrial Targeted Fusion Peptide Exhibits Remarkable Cytotoxicity
Mol Cancer Ther. 2006;5 (8):1944-1949 - PMID: 16928814 - DOI: 10.1158/1535-7163.MCT-05-0509
Oligomerization of CXCL10 Is Necessary for Endothelial Cell Presentation and In Vivo Activity.
J Immunol. 2006;177:6991-8 - PMID: 17082614 - DOI: 10.4049/jimmunol.177.10.6991
Murine B16 Melanomas Expressing High Levels of the Chemokine Stromal-Derived Factor-1/CXCL12 Induce Tumor-Specific T Cell Chemorepulsion and Escape from Immune Control.
J Immunol. 2006;176(5):2902-14 - PMID: 16493048 - DOI: 10.4049/jimmunol.176.5.2902
N-Cadherin and Keratinocyte Growth Factor Receptor Mediate the Functional Interplay between Ki-RASG12V and p53V143A in Promoting Pancreatic Cell Migration, Invasion, and Tissue Architecture Disruption.
Mol Cell Biol. 2006;26(11):4185-200 - PMID: 16705170 - PMCID: PMC1489079 - DOI: 10.1128/MCB.01055-05
Simultaneous fluorescence imaging of protease expression and vascularity during murine colonoscopy for colonic lesion characterization.
Gastrointest Endosc. 2006;64(4):589-97 - PMID: 16996355 - DOI: 10.1016/j.gie.2006.02.048
Molecular imaging of myocardial infarction.
J Mol Cell Cardiol. 2006;41:921-933 - PMID: 17067633 - DOI: 10.1016/j.yjmcc.2006.09.008
Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries.
Imaging pancreatic cancer with a peptide-nanoparticle conjugate targeted to normal pancreas
Bioconjug Chem. 2006;17(4):905-911 - PMID: 16848396 - DOI: 10.1021/bc060035+
Fluorescence Probe with a pH-Sensitive Trigger
Bioconjug Chem. 2006;17 (2):255-257 - PMID: 16536452 - DOI: 10.1021/bc050330e
Linear Polyethyleneimine Grafted to a Hyperbranched Poly(ethylene glycol)-like Core: A Copolymer for Gene Delivery.
Bioconjug Chem. 2006;17(1):125-31 - PMID: 16417260 - DOI: 10.1021/bc050083e
Development of nanoparticle libraries for biosensing.
Bioconjug Chem. 2006;17(1):109-13 - PMID: 16417258 - DOI: 10.1021/bc050290e
SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration.
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Treatment of schwannomas with an oncolytic recombinant herpes simplex virus in murine models of neurofibromatosis type 2.
Hum Gene Ther. 2006;17(1):20-30 - PMID: 16409122 - DOI: 10.1089/hum.2006.17.20
Enzyme-based visualization of receptor-ligand binding in tissues.
Lab Invest. 2006;86(5):517-25 - PMID: 16568109 - DOI: 10.1038/labinvest.3700404
Targeted imaging of human endothelial-specific marker in a model of adoptive cell transfer.
Lab Invest. 2006;86(6):599-609 - PMID: 16607378 - DOI: 10.1038/labinvest.3700421
Does FXIII Deficiency Impair Wound Healing after Myocardial Infarction?
Normalized transillumination of fluorescent proteins in small animals.
Mol Imaging. 2006;5 (2):153-9 - PMID: 16954030
Cellular Imaging of Inflammation in Atherosclerosis Using Magnetofluorescent Nanomaterials
Mol Imaging. 2006;(5) 2 :85-92 - PMID: 16954022
Clickable nanoparticles for targeted imaging
Mol Imaging. 2006;(5) 2:122-128 - PMID: 16954026
High throughput identification of phage-derived imaging agents
Mol Imaging. 2006;5(1):24-30 - PMID: 16779967
Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery.
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Protease-mediated phototoxicity of a polylysine-chlorin(E6) conjugate.
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Conjugation of a Photosensitizer to an Oligoarginine-based Cell-penetrating Peptide Increases the Efficacy of Photodynamic Therapy
ChemMedChem. 2006;1(4):458-463 - PMID: 16892381 - DOI: 10.1002/cmdc.200500036
An albumin-activated far-red fluorochrome for in vivo imaging
ChemMedChem. 2006;1(1):66-69 - PMID: 16892337 - DOI: 10.1002/cmdc.200500028
Development of a dual fluorogenic and chromogenic dipeptidyl peptidase IV substrate.
Bioorg Med Chem. 2006;16:2599-2602 - PMID: 16517162 - DOI: 10.1016/j.bmcl.2006.02.045
Comparison of lymphotropic nanoparticle-enhanced MRI sequences in patients with various primary cancers.
AJR Am J Roentgenol. 2006;187(6):W582-8 - PMID: 17114509 - DOI: 10.2214/AJR.05.0873
Ferumoxtran-10-Enhanced MR Lymphangiography: Does Contrast-Enhanced Imaging Alone Suffice for Accurate Lymph Node Characterization?
AJR Am J Roentgenol. 2006;186(1):144-8 - PMID: 16357394 - DOI: 10.2214/AJR.04.1287
In-vivo imaging of tumor associated urokinase-type plasminogen activator activity.
J Biomed Opt. 2006;11(3):34013 - PMID: 16822063 - DOI: 10.1117/1.2204029
Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy.
J Biomed Opt. 2006;11(2):21009 - PMID: 16674184 - DOI: 10.1117/1.2186337
In Vivo Phage Display Selection Yields Atherosclerotic Plaque Targeted Peptides for Imaging.
Mol Imaging Biol. 2006;8(4):201-7 - PMID: 16791746 - DOI: 10.1007/s11307-006-0043-6
Development of water-soluble far-red fluorogenic dyes for enzyme sensing
Tetrahedron. 2006;62:578-585
Cell-specific targeting of nanoparticles by multivalent attachment of small molecules
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Looking and Listening to light: the evolution of whole-body photonic imaging
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Molecular Imaging in the Clinical Arena
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Near-Infrared Fluorescent Imaging of Matrix Metalloproteinase Activity After Myocardial Infarction
Circulation. 2005;111:1800-1805 - PMID: 15809374 - PMCID: PMC3733536 - DOI: 10.1161/01.CIR.0000160936.91849.9F
Detection of Vascular Adhesion Molecule-1 Expression Using a Novel Multimodal Nanoparticle
Circ Res. 2005;96(3):327-36 - PMID: 15653572 - DOI: 10.1161/01.RES.0000155722.17881.dd
Volumetric tomography of fluorescent proteins through small animals in vivo
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Use of gene expression profiling to direct in vivo molecular imaging of lung cancer
Proc Natl Acad Sci U S A. 2005;102(40):14404-14409 - PMID: 16183744 - PMCID: PMC1242291 - DOI: 10.1073/pnas.0503920102
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-{beta} signals in vivo
Proc Natl Acad Sci U S A. 2005;102(2):419-24 - PMID: 15623559 - PMCID: PMC544311 - DOI: 10.1073/pnas.0408197102
The progress and promise of molecular imaging probes in oncologic drug development.
Clin Cancer Res. 2005;11(22):7967-85 - PMID: 16299226 - DOI: 10.1158/1078-0432.CCR-05-1302
Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes
Polymeric Nanoparticle Preparation that Eradicates Tumors.
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Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression
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Detection of Early Antiangiogenic Effects in Human Colon Adenocarcinoma Xenografts: In vivo Changes of Tumor Blood Volume in Response to Experimental VEGFR Tyrosine Kinase Inhibitor
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In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time magnetic resonance imaging
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Tomographic Fluorescence Mapping of Tumor Targets
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In vivo imaging of S-TRAIL-mediated tumor regression and apoptosis
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Codon-optimized gaussia luciferase cDNA for Mammalian gene expression in culture and in vivo
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Mapping of nodal disease in locally advanced prostate cancer: Rethinking the clinical target volume for pelvic nodal irradiation based on vascular rather than bony anatomy
Int J Radiat Oncol Biol Phys. 2005;63(4):1262-9 - PMID: 16253781 - DOI: 10.1016/j.ijrobp.2005.07.952
DTPA-bisamide-Based MR Sensor Agents for Peroxidase Imaging
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A novel mouse model for segmental orthotopic colon cancer
Int J Cancer. 2005;117(3):335-9 - PMID: 15900588 - DOI: 10.1002/ijc.21185
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Novel Multiwavelength Microscopic Scanner for Mouse Imaging.
Nanoparticles for the Optical Imaging of Tumor E-selectin
Neoplasia. 2005;7(10):904-11 - PMID: 16242073 - DOI: 10.1593/neo.05352
Imaging of VEGF receptor kinase inhibitor-induced antiangiogenic effects in drug-resistant human adenocarcinoma model
Bone Marrow-Derived lin(-)c-kit(+)Sca-1(+) Stem Cells Do Not Contribute to Vasculogenesis in Lewis Lung Carcinoma
Near-infrared fluorescent imaging of cerebral thrombi and blood-brain barrier disruption in a mouse model of cerebral venous sinus thrombosis
J Cereb Blood Flow Metab. 2005;25(2):226-33 - PMID: 15678125 - DOI: 10.1038/sj.jcbfm.9600023
Optical Imaging of Spontaneous Breast Tumors Using Protease Sensing
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An Effective Method of On-Resin Disulfide Bond Formation in Peptides
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Monofunctional near-infrared fluorochromes for imaging applications
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Protamine as an efficient membrane-translocating Peptide
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Synthesis and Activity of C11-Modified Wortmannin Probes for P13 Kinase
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In Vivo Imaging of Activated Endothelium Using an Anti-VCAM-1 Magneto optical Probe
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A Branched Fluorescent Peptide Probe for Imaging of Activated Platelets
Mol Pharmacol. 2005;2:92-95 - PMID: 15804182 - DOI: 10.1021/mp0499048
Arthritis imaging using a near-infrared fluorescence folate-targeted probe
Fluorescent protein tomography scanner for small animal imaging
IEEE T Med Imaging. 2005;24(7):878-85 - PMID: 16011317 - DOI: 10.1109/tmi.2004.843254
Magnetic resonance imaging and characterization of spontaneous lesions in a transgenic mouse model of tuberous sclerosis as a model for endothelial cell-based transgene delivery.
Hum Gene Ther. 2005;16:1367-76 - PMID: 16390268 - DOI: 10.1089/hum.2005.16.1367
Molecular Optical Imaging: Applications Leading to the Development of Present Day Therapeutics
Mechanism-Based Fluorescent Reporter for Protein Kinase A Detection
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Transport Of Surface-Modified Nanoparticles Through Cell Monolayers
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Detection of dysplastic intestinal adenomas using a fluorescent folate imaging probe
Mol Imaging. 2005;4 (1):67-74 - PMID: 15912902
MIPortal: A High Capacity Server for Molecular Imaging Research.
Mol Imaging. 2005;4(4):425-31 - PMID: 16285904 - DOI: 10.2310/7290.2005.05136
Transfection agent induced nanoparticle cell loading
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Methotrexate-induced accumulation of fluorescent annexin v in collagen-induced arthritis
Mol Imaging. 2005;4(1):1-6 - PMID: 15967121 - DOI: 10.1162/15353500200504142
Meeting Report: High-Throughput Technologies for In Vivo Imaging Agents
Mol Imaging. 2005;4:1-6
Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle
Magn Reson Med. 2005;54(3):718-724 - PMID: 16086367 - DOI: 10.1002/mrm.20617
Chemical and Genetic Sensors in Biomedical Research.
J Biomed Opt. 2005;10(4):41201 - PMID: 23171967
Validation of in vivo fluorochrome concentrations measured using fluorescence molecular tomography
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Myeloperoxidase Activity Imaging Using (67)Ga Labeled Substrate.
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Optical zymography for specific detection of urokinase plasminogen activator activity in biological samples
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Development of a near infrared fluorescence catheter: operating characteristics and feasibility for atherosclerotic plaque detection
J Phys D Appl Phys. 2005;38:2701-2707
A pilot study of lymphotrophic nanoparticle-enhanced magnetic resonance imaging technique in early stage testicular cancer: a new method for noninvasive lymph node evaluation.
Urology. 2005;66(5):1066-71 - PMID: 16286125 - DOI: 10.1016/j.urology.2005.05.049
Quantitative analysis of chemotherapeutic effects in tumors using in vivo staining and correlative histology
Mouse Models of Human Non-Small-Cell Lung Cancer: Raising the Bar.
Cold Spring Harb Symp Quant Biol. 2005;70:241-250 - PMID: 16869760 - DOI: 10.1101/sqb.2005.70.037
Magnetic resonance and fluorescence based molecular imaging technologies.
Prog Drug Res. 2005;62:83-115 - PMID: 16329255 - DOI: 10.1007/3-7643-7426-8_3
Magnetic resonance signal amplification probes
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Fluorescent Protein Tomography Scanner for Small Animal Imaging
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Molecular Imaging of Factor XIIIa Activity in Thrombosis Using a Novel, Near-Infrared Fluorescent Contrast Agent That Covalently Links to Thrombi.
Circulation. 2004;110(2):170-6 - PMID: 15210587 - DOI: 10.1161/01.CIR.0000134484.11052.44
Magnetic Relaxation Switch Immunosensors Detect Enantiomeric Impurities
Angew Chem Int Ed Engl. 2004;43(18):2395-2399 - PMID: 15114571 - DOI: 10.1002/anie.200352998
Seeing within: molecular imaging of the cardiovascular system
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Sensitive, noninvasive detection of lymph node metastases.
Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate.
Proc Natl Acad Sci U S A. 2004;101(33):12294-9 - PMID: 15304657 - PMCID: PMC514472 - DOI: 10.1073/pnas.0401137101
Imaging inflammation of the pancreatic islets in type 1 diabetes.
Proc Natl Acad Sci U S A. 2004;101(34):12634-9 - PMID: 15304647 - PMCID: PMC515109 - DOI: 10.1073/pnas.0404307101
Intracellular cargo delivery using tat peptide and derivatives
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Detection of invasive colon cancer using a novel, targeted, library-derived fluorescent peptide.
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Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas.
Cancer Res. 2004;64(12):4069-77 - PMID: 15205313 - DOI: 10.1158/0008-5472.CAN-04-1243
Inducible release of TRAIL fusion proteins from a proapoptotic form for tumor therapy
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In Vivo Imaging of ?-Galactosidase Activity Using Far Red Fluorescent Switch
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Novel nanosensors for rapid analysis of telomerase activity
Cancer Res. 2004;64:639-43 - PMID: 14744779 - DOI: 10.1158/0008-5472.can-03-2798
In vivo imaging of HIV protease activity in amplicon vector-transduced gliomas
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Catheter-based in vivo imaging of enzyme activity and gene expression: feasibility study in mice.
Radiology. 2004;231(3):659-66 - PMID: 15163807 - DOI: 10.1148/radiol.2313030831
In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment response.
Arth Rheum/AR C Res. 2004;50(8):2459-65 - PMID: 15334458 - DOI: 10.1002/art.20379
Imaging of Stem Cell Recruitment to Ischemic Infarcts in a Murine Model
Stroke. 2004;35:952-7 - PMID: 14988578 - DOI: 10.1161/01.STR.0000120308.21946.5D
Design, synthesis, and characterization of urokinase plasminogen-activator-sensitive near-infrared reporter.
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A novel method for imaging apoptosis using a caspase-1 near-infrared fluorescent probe.
Synthesis and Properties of Fluorescent NF-kappaB-Recognizing Hairpin Oligodeoxyribonucleotide Decoys.
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Developing a Peptide-Based Near-Infrared Molecular Probe for Protease Sensing.
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Magneto/Optical annexin v, a multimodal protein.
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Novel hyperbranched dendron for gene transfer in vitro and in vivo.
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A dual fluorochrome probe for imaging proteases
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Molecular imaging of gene therapy for cancer
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Fluorescence molecular imaging of small animal tumor models.
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Enhancing membrane permeability by Fatty acylation of oligoarginine peptides.
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Optimal modification of annexin v with fluorescent dyes
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Surface-functionalized nanoparticle library yields probes for apoptotic cells
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Use of magnetic nanoparticles as nanosensors to probe for molecular interactions
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Imaging reactive oxygen species in arthritis.
Mol Imaging. 2004;3(3):159-62 - PMID: 15530251 - DOI: 10.1162/15353500200404124
Murine Neuronal Progenitor Cells are Preferentially Recruited to Tumor Vasculature via alpha(4)-integrin and SDF-1alpha-Dependent Mechanisms.
Cancer Biol Ther. 2004;3(9):838-44 - PMID: 15254391 - DOI: 10.4161/cbt.3.9.1036
Human myeloperoxidase: A potential target for molecular MR imaging in atherosclerosis.
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Measurement of tumor interstitial volume fraction: Method and implication for drug delivery
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Fluorescein isothiocyanate-hapten immunoassay for determination of peptide-cell interactions.
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Singular-value analysis and optimization of experimental parameters in fluorescence molecular tomography
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Illuminating the dynamics of intracellular activity with
Mech Chem Biosyst. 2004;1:133-45 - PMID: 16783939
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
N Engl J Med. 2003;348:2491-9 - PMID: 12815134 - DOI: 10.1056/NEJMoa022749
Molecular imaging in drug discovery and development
Nat Rev Drug Discov. 2003;2:123-31 - PMID: 12563303 - DOI: 10.1038/nrd1007
Shedding light onto live molecular targets
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Magnetic sensors for protease assays
Angew Chem Int Ed Engl. 2003;42:1375-8 - PMID: 12671972 - DOI: 10.1002/anie.200390352
Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological media
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Arginine containing peptides as delivery vectors
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A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation
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In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors
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Near-infrared fluorescent imaging of tumor apoptosis
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Steady-state blood volume measurements in experimental tumors with different angiogenic burdens a study in mice
Radiology. 2003;226:214-20 - PMID: 12511693 - DOI: 10.1148/radiol.2261012140
Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo
Oncogene. 2003;22:6865-72 - PMID: 14534533 - DOI: 10.1038/sj.onc.1206748
The transferrin receptor: a potential molecular imaging marker for human cancer.
Neoplasia. 2003;5(6):495-506 - PMID: 14965443 - PMCID: PMC1502574 - DOI: 10.1016/s1476-5586(03)80034-9
Murine Lewis lung carcinoma-derived endothelium expresses markers of endothelial activation and requires tumor-specific extracellular matrix in vitro
Optical imaging of apoptosis as a biomarker of tumor response to chemotherapy
Near-infrared optical imaging of proteases in cancer
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Uptake and metabolism of a dual fluorochrome Tat-nanoparticle in HeLa cells
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Enhanced tumor detection using a folate receptor-targeted near-infrared fluorochrome conjugate
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High efficiency synthesis of a bioconjugatable near-infrared fluorochrome
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In vivo tracking of neural progenitor cell migration to glioblastomas
Hum Gene Ther. 2003;14:1247-54 - PMID: 12952596 - DOI: 10.1089/104303403767740786
Novel Factor XIII Probes for Blood Coagulation Imaging
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Neural stem cell biology may be well suited for improving brain tumor therapies
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Protease sensors for bioimaging
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Ratio imaging of enzyme activity using dual wavelength optical reporters
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Miniaturized multichannel near infrared endoscope for mouse imaging
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Pan and sentinel lymph node visualization using a near-infrared fluorescent probe
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Synthesis and properties of sulfhydryl-reactive near-infrared cyanine fluorochromes for fluorescence imaging
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A novel polyacrylamide magnetic nanoparticle contrast agent for molecular imaging using MRI
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A submillimeter resolution fluorescence molecular imaging system for small animal imaging
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A practical approach for the preparation of monofunctional azulenyl squaraine dye.
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Engineering of technetium-99m-binding artificial receptors for imaging gene expression
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Scaling down imaging: molecular mapping of cancer in mice
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Magnetic relaxation switches capable of sensing molecular interactions
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Arthritis critically dependent on innate immune system players
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Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice
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Fluorescence molecular tomography resolves protease activity in vivo
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In vivo imaging of proteolytic activity in atherosclerosis
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Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis
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An azulene dimer as a near-infrared quencher
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DNA-based magnetic nanoparticle assembly acts as a magnetic relaxation nanoswitch allowing screening of DNA-cleaving agents
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Imaging of differential protease expression in breast cancers for detection of aggressive tumor phenotypes
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Feasibility of in vivo multichannel optical imaging of gene expression: experimental study in mice
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In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe
Arterioscler Thromb Vasc Biol. 2002;22:1929-35 - PMID: 12426227 - DOI: 10.1161/01.atv.0000033089.56970.2d
Cellular activation of the self-quenched fluorescent reporter probe in tumor microenvironment
MRI of transgene expression: correlation to therapeutic gene expression
Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model
Detection of spontaneous schwannomas by MRI in a transgenic murine model of neurofibromatosis type 2
High throughput magnetic resonance imaging for evaluating targeted nanoparticle probes
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Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes
Bioconjug Chem. 2002;13:554-60 - PMID: 12009946 - DOI: 10.1021/bc015555d
Magnetic resonance imaging of inducible E-selectin expression in human endothelial cell culture
Bioconjug Chem. 2002;13:122-7 - PMID: 11792187 - DOI: 10.1021/bc0155521
Novel near-infrared cyanine fluorochromes: synthesis, properties, and bioconjugation
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Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles
Bioconjug Chem. 2002;13:264-8 - PMID: 11906263 - DOI: 10.1021/bc015563u
Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake
Bioconjug Chem. 2002;13:840-4 - PMID: 12121140 - DOI: 10.1021/bc0255236
Targeting of MPEG-protected polyamino acid carrier to human E-selectin in vitro
Amino Acids. 2002;23:301-8 - PMID: 12373551 - DOI: 10.1007/s00726-001-0142-2
A receptor-targeted near-infrared fluorescence probe for in vivo tumor imaging
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A novel near-infrared fluorescence sensor for detection of thrombin activation in blood
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Oligomerization of paramagnetic substrates result in signal amplification and can be used for MR imaging of molecular targets
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In vivo tomographic imaging of near-infrared fluorescent probes
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Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI
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Coded aperture nuclear scintigraphy: a novel small animal imaging technique
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Would near-infrared fluorescence signals propagate through large human organs for clinical studies?
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Fast analytical approximation for arbitrary geometries in diffuse optical tomography.
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Would near-infrared fluorescence signals propagate through large human organs for clinical studies? Errata.
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MRI of insulitis in autoimmune diabetes
Magn Reson Med. 2002;47:751-8 - PMID: 11948737 - DOI: 10.1002/mrm.10110
Detection of lymph node metastases by contrast-enhanced MRI in an experimental model
Magn Reson Med. 2002;47:292-7 - PMID: 11810672 - DOI: 10.1002/mrm.10068
Novel branching membrane translocational peptide as gene delivery vector
Bioorg Med Chem. 2002;10:3609-14 - PMID: 12213476 - DOI: 10.1016/s0968-0896(02)00248-1
Charge-coupled-device based scanner for tomography of fluorescent near-infrared probes in turbid media
Med Phys. 2002;29:803-9 - PMID: 12033576 - DOI: 10.1118/1.1470209
Optical-based molecular imaging: contrast agents and potential medical applications
Eur J Radiol. 2002;13:231-43 - PMID: 12598985 - DOI: 10.1007/s00330-002-1610-0
Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging
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Intermolecular [8+2] cycloaddition reactions of 2H-3-methoxycarbonylcyclohepta[b]furan-2-one with vinyl ethers: an approach to bicyclo[5.3.0]azulene derivatives.
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Steady-state and dynamic contrast MR imaging of human prostate cancer xenograft tumors: a comparative study
Technol Cancer Res T. 2002;1:489-95 - PMID: 12625776 - DOI: 10.1177/153303460200100609
Molecular imaging of MMP expression and therapeutic MMP inhibition
Acad Radiol. 2002;9 Suppl 2:S314-5 - PMID: 12188259 - DOI: 10.1016/s1076-6332(03)80214-3
MR lymphangiography for detection of minimal nodal disease in patients with prostate cancer
Acad Radiol. 2002;9 Suppl 2:S312-3 - PMID: 12188258 - DOI: 10.1016/s1076-6332(03)80213-1
Some tools for molecular imaging
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Imaging cathepsin B up-regulation in HT-1080 tumor models using fluorescence-mediated molecular tomography (FMT)
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Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI
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Crosslinked iron oxides (CLIO): a new platform for the development of targeted MR contrast agents
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A clearer vision for in vivo imaging
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In vivo molecular target assessment of matrix metalloproteinase inhibition
Nature Med. 2001;7:743-8 - PMID: 11385514 - DOI: 10.1038/89126
Magnetic Nanosensors for the Detection of Oligonucleotide Sequences.
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Optical imaging of matrix metalloproteinase-2 activity in tumors: feasibility study in a mouse model
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Human transferrin receptor gene as a marker gene for MR imaging
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Molecular imaging
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Noninvasive in vivo measurement of beta-cell mass in mouse model of diabetes
Diabetes. 2001;50:2231-6 - PMID: 11574403 - DOI: 10.2337/diabetes.50.10.2231
Size optimization of synthetic graft copolymers for in vivo angiogenesis imaging
Bioconjug Chem. 2001;12:213-9 - PMID: 11312682 - DOI: 10.1021/bc000091p
DNA binding chelates for nonviral gene delivery imaging
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Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation.
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Isolation, characterization, and recovery of small peptide phage display epitopes selected against viable malignant glioma cells
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In vivo imaging of gene and cell therapies
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Tunneled peritoneal catheter placement under sonographic and fluoroscopic guidance in the palliative treatment of malignant ascites
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Normal T-cell response and in vivo magnetic resonance imaging of T cells loaded with HIV transactivator-peptide-derived superparamagnetic nanoparticles
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In vivo imaging of gene expression
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Glossary of molecular imaging terminology
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MRI contrast agents for evaluating focal hepatic lesions
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Splenic imaging with ultrasmall superparamagnetic iron oxide ferumoxtran-10 (AMI-7227): preliminary observations
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[Progress in optical imaging]
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[Experimental and clinical approaches to lymph node imaging]
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Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells
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In vivo magnetic resonance imaging of transgene expression
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Tyrosinase mutants are capable of prodrug activation in transfected nonmelanotic cells
Cancer Res. 2000;60:6656-62 - PMID: 11118049
In vivo imaging of proteolytic enzyme activity using a novel molecular reporter
Cancer Res. 2000;60:4953-8 - PMID: 10987312
Tumoral distribution of long-circulating dextran-coated iron oxide nanoparticles in a rodent model
Radiology. 2000;214:568-74 - PMID: 10671613 - DOI: 10.1148/radiology.214.2.r00fe19568
Imaging of tumour neovasculature by targeting the TGF-beta binding receptor endoglin
Eur J Cancer. 2000;36:675-81 - PMID: 10738134 - DOI: 10.1016/s0959-8049(99)00335-4
Macrocyclic chelators with paramagnetic cations are internalized into mammalian cells via a HIV-tat derived membrane translocation peptide
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Improvement of MRI probes to allow efficient detection of gene expression
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Quantitation of HSV mass distribution in a rodent brain tumor model
Gene Ther. 2000;7:1648-55 - PMID: 11083473 - DOI: 10.1038/sj.gt.3301272
New approaches for imaging in gene therapy
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Engineering membrane proteins for nuclear medicine: applications for gene therapy and cell tracking
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Strategies in in vivo molecular imaging
Neoreviews. 2000;1:225-232
Appllications of In Vivo Molecular Imaging in Biology and Medicine
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In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
Nat Biotechnol. 1999;17:375-8 - PMID: 10207887 - DOI: 10.1038/7933
Approaches and agents for imaging the vascular system
Adv Drug Deliv Rev. 1999;37:279-293 - PMID: 10837740 - DOI: 10.1016/s0169-409x(98)00098-2
Near-infrared optical imaging of protease activity for tumor detection
Radiology. 1999;213:866-70 - PMID: 10580968 - DOI: 10.1148/radiology.213.3.r99dc14866
Molecular imaging: exploring the next frontier
Radiology. 1999;212:609-14 - PMID: 10478223 - DOI: 10.1148/radiology.212.3.r99se18609
In vivo assessment of vascular endothelial growth factor-induced angiogenesis
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Cerebrovascular dynamics of autoregulation and hypoperfusion. An MRI study of CBF and changes in total and microvascular cerebral blood volume during hemorrhagic hypotension
Stroke. 1999;30:2197-204; discussion 2204-5 - PMID: 10512929 - DOI: 10.1161/01.str.30.10.2197
Treatment of experimental brain tumors with trombospondin-1 derived peptides: an in vivo imaging study
High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates
Bioconjug Chem. 1999;10:186-91 - PMID: 10077466 - DOI: 10.1021/bc980125h
Preparation of a cathepsin D sensitive near-infrared fluorescence probe for imaging
Bioconjug Chem. 1999;10:892-6 - PMID: 10502358 - DOI: 10.1021/bc990052h
MR lymphangiography using ultrasmall superparamagnetic iron oxide in patients with primary abdominal and pelvic malignancies: radiographic-pathologic correlation
AJR Am J Roentgenol. 1999;172:1347-51 - PMID: 10227514 - DOI: 10.2214/ajr.172.5.10227514
Improved delineation of human brain tumors on MR images using a long-circulating, superparamagnetic iron oxide agent
J Magn Reson Imaging. 1999;9:228-32 - PMID: 10077018 - DOI: 10.1002/(sici)1522-2586(199902)9:2<228::aid-jmri12>3.0.co;2-k
Mechanism of gadophrin-2 accumulation in tumor necrosis
J Magn Reson Imaging. 1999;9:336-41 - PMID: 10077034 - DOI: 10.1002/(sici)1522-2586(199902)9:2<336::aid-jmri28>3.0.co;2-3
MR imaging of the liver with Gd-BOPTA: quantitative analysis of T1-weighted images at two different doses
J Magn Reson Imaging. 1999;10:80-3 - PMID: 10398981 - DOI: 10.1002/(sici)1522-2586(199907)10:1<80::aid-jmri11>3.0.co;2-s
Targeting of green fluorescent protein expression to the cell surface
Biochem Bioph Res Co. 1999;262:638-42 - PMID: 10471377 - DOI: 10.1006/bbrc.1999.1251
The development of in vivo imaging systems to study gene expression.
Trends Biotechnol. 1998;16(1):5-10 - PMID: 9470227 - DOI: 10.1016/S0167-7799(97)01150-5
MR imaging of gene delivery to the central nervous system with an artificial vector.
Radiology. 1998;208(1):65-71 - PMID: 9646794 - DOI: 10.1148/radiology.208.1.9646794
Efficacy of thrombolytic therapy in pulmonary embolism determined by MION-enhanced MRA: an experimental study in rabbits.
Invest Radiol. 1998;33(12):853-7 - PMID: 9851818 - DOI: 10.1097/00004424-199812000-00002
Non-invasive in vivo mapping of tumour vascular and interstitial volume fractions.
Eur J Cancer. 1998;34(9):1448-54 - PMID: 9849430 - DOI: 10.1016/s0959-8049(98)00195-6
Antibody-mediated versus nontargeted delivery in a human small cell lung carcinoma model.
Bioconjug Chem. 1998;9(2):184-91 - PMID: 9548533 - DOI: 10.1021/bc970146w
Design of metal-binding green fluorescent protein variants.
Biochim Biophys Acta. 1998;1397(1):56-64 - PMID: 9545533 - DOI: 10.1016/s0167-4781(97)00221-2
Measuring transferrin receptor gene expression by NMR imaging.
Biochim Biophys Acta. 1998;1402(3):239-49 - PMID: 9606982 - DOI: 10.1016/s0167-4889(98)00002-0
Mapping the in vivo distribution of herpes simplex virions.
Hum Gene Ther. 1998;9(11):1543-9 - PMID: 9694153 - DOI: 10.1089/hum.1998.9.11-1543
Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation.
Magn Reson Med. 1998;39(4):615-24 - PMID: 9543424 - DOI: 10.1002/mrm.1910390415
Continuous assessment of perfusion by tagging including volume and water extraction (CAPTIVE): a steady-state contrast agent technique for measuring blood flow, relative blood volume fraction, and the water extraction fraction.
Magn Reson Med. 1998;40(5):666-78 - PMID: 9797148 - DOI: 10.1002/mrm.1910400504
Novel gliosarcoma cell line expressing green fluorescent protein: A model for quantitative assessment of angiogenesis.
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Preclinical evaluation and phase I clinical trial of a 99mTc-labeled synthetic polymer used in blood pool imaging.
AJR Am J Roentgenol. 1998;171(1):137-43 - PMID: 9648777 - DOI: 10.2214/ajr.171.1.9648777
Targeting gene therapy vectors to CNS malignancies.
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Imaging of mediastinal lymph nodes: CT, MR, and FDG PET.
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Uptake of dextran-coated monocrystalline iron oxides in tumor cells and macrophages.
J Magn Reson Imaging. 1998;7(6):1140-5 - PMID: 9400860 - DOI: 10.1002/jmri.1880070629
Preclinical assessment of hepatocyte-targeted MR contrast agents in stable human liver cell cultures.
J Magn Reson Imaging. 1998;8(3):687-9 - PMID: 9626887 - DOI: 10.1002/jmri.1880080326
Intracellular magnetic labeling of lymphocytes for in vivo trafficking studies.
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MR imaging of lymph nodes in patients with primary abdominal and pelvic malignancies using ultrasmall superparamagnetic iron oxide (Combidex).
Acad Radiol. 1998;5 Suppl 1:S167-9, discussion S183-4 - PMID: 9561072 - DOI: 10.1016/s1076-6332(98)80095-0
Differentiation of liver hemangiomas from metastases and hepatocellular carcinoma at MR imaging enhanced with blood-pool contrast agent Code-7227.
Radiology. 1997;202(3):687-91 - PMID: 9051017 - DOI: 10.1148/radiology.202.3.9051017
Paramagnetic metal scavenging by melanin: MR imaging.
Radiology. 1997;204(2):417-23 - PMID: 9240529 - DOI: 10.1148/radiology.204.2.9240529
MR imaging and scintigraphy of gene expression through melanin induction.
Radiology. 1997;204(2):425-9 - PMID: 9240530 - DOI: 10.1148/radiology.204.2.9240530
Relative blood volume measurements by magnetic resonance imaging facilitate detection of testicular torsion.
Invest Radiol. 1997;32(12):763-9 - PMID: 9406017 - DOI: 10.1097/00004424-199712000-00007
Tumor cell endocytosis imaging facilitates delineation of the glioma-brain interface.
Exp Neurol. 1997;143(1):61-9 - PMID: 9000446 - DOI: 10.1006/exnr.1996.6350
Application of a stable cell culture assay for the functional assessment of novel MR contrast agents.
Eur Radiol. 1997;7(4):527-31 - PMID: 9204333 - DOI: 10.1007/s003300050197
Dynamic liver imaging with iron oxide agents: effects of size and biodistribution on contrast.
Magn Reson Med. 1997;37(6):885-90 - PMID: 9178240 - DOI: 10.1002/mrm.1910370613
A long-circulating co-polymer in "passive targeting" to solid tumors.
J Drug Target. 1997;4(5):321-30 - PMID: 9169989 - DOI: 10.3109/10611869708995848
Contrast enhancement in experimental radiation-induced liver injury: comparison of hepatocellular and reticuloendothelial particulate contrast agents.
J Magn Reson Imaging. 1997;6(2):286-90 - PMID: 9132091 - DOI: 10.1002/jmri.1880060205
Magnetically labeled cells can be detected by MR imaging.
J Magn Reson Imaging. 1997;7(1):258-63 - PMID: 9039625 - DOI: 10.1002/jmri.1880070140
In vivo localization of diglycylcysteine-bearing synthetic peptides by nuclear imaging of oxotechnetate transchelation.
Nucl Med Biol. 1997;24(8):739-42 - PMID: 9428599 - DOI: 10.1016/s0969-8051(97)00117-0
Macromolecular intravenous contrast agent for MR lymphography: characterization and efficacy studies.
Radiology. 1996;198(2):365-70 - PMID: 8596833 - DOI: 10.1148/radiology.198.2.8596833
An adduct of cis-diamminedichloroplatinum(II) and poly(ethylene glycol)poly(L-lysine)-succinate: synthesis and cytotoxic properties.
Bioconjug Chem. 1996;7(1):144-9 - PMID: 8742003 - DOI: 10.1021/bc950089b
Magnetically labeled secretin retains receptor affinity to pancreas acinar cells.
Bioconjug Chem. 1996;7(3):311-6 - PMID: 8816953 - DOI: 10.1021/bc960003u
MR of carcinoma-specific monoclonal antibody conjugated to monocrystalline iron oxide nanoparticles: the potential for noninvasive diagnosis.
AJNR Am J Neuroradiol. 1996;17(3):411-8 - PMID: 8881233 - PMCID: PMC8337991
Can gadolinium be safely given in renal failure?
AJR Am J Roentgenol. 1996;167(1):278-9 - PMID: 8659405 - DOI: 10.2214/ajr.167.1.8659405
Drug delivery to lymphatic tissue.
Crit Rev Ther Drug Carrier Syst. 1996;13(1-2):57-84 - PMID: 8853959
An organotypical in vitro model of the liver parenchyma for uptake studies of diagnostic MR receptor agents.
Magn Reson Imaging. 1996;13(7):991-1002 - PMID: 8583878 - DOI: 10.1016/0730-725x(95)00053-j
Targeted contrast agents in MR imaging.
Magn Reson Imaging. 1996;4(1):171-84 - PMID: 8673713
Liver. II: Iron oxide-based reticuloendothelial contrast agents for MR imaging. Clinical review.
Magn Reson Imaging. 1996;4(1):53-60 - PMID: 8673716
[Development and experimental use of receptor-specific MR contrast media]
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[Lymph node diagnosis with imaging methods. An overview with special reference to recent developments in the area of MR contrast media]
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Long-circulating blood pool imaging agents
Adv Drug Deliv Rev. 1995;15:335-348
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Experimental gastrointestinal hemorrhage: detection with contrast-enhanced MR imaging and scintigraphy.
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Cerebral iron oxide distribution: in vivo mapping with MR imaging.
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MR imaging of phagocytosis in experimental gliomas.
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Inflammation: imaging with methoxy poly(ethylene glycol)-poly-L-lysine-DTPA, a long-circulating graft copolymer.
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Cellular uptake and trafficking of a prototypical magnetic iron oxide label in vitro.
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Quantitation of slow drug release from an implantable and degradable gentamicin conjugate by in vivo magnetic resonance imaging.
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Comparison of intracerebral inoculation and osmotic blood-brain barrier disruption for delivery of adenovirus, herpesvirus, and iron oxide particles to normal rat brain.
Am J Pathol. 1995;147(6):1840-51 - PMID: 7495307 - PMCID: PMC1869962
Selective uptake of viral and monocrystalline particles delivered intra-arterially to experimental brain neoplasms.
Hum Gene Ther. 1995;6(12):1543-52 - PMID: 8664379 - DOI: 10.1089/hum.1995.6.12-1543
MR lymphography with a lymphotropic T1-type MR contrast agent: Gd-DTPA-PGM.
Magn Reson Med. 1995;33(1):88-92 - PMID: 7891541 - DOI: 10.1002/mrm.1910330113
MR imaging of neuronal transport in the guinea pig facial nerve: initial findings.
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MR lymphography: study of a high-efficiency lymphotrophic agent.
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Determinants of in vivo MR imaging of slow axonal transport.
Radiology. 1994;193(2):485-91 - PMID: 7526413 - DOI: 10.1148/radiology.193.2.7526413
Pancreatic receptors: initial feasibility studies with a targeted contrast agent for MR imaging.
Radiology. 1994;193(2):527-31 - PMID: 7972773 - DOI: 10.1148/radiology.193.2.7972773
Liver MR imaging with iron oxides: toward consensus and clinical practice.
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Synthetic copolymer kit for radionuclide blood-pool imaging.
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Trapping of dextran-coated colloids in liposomes by transient binding to aminophospholipid: preparation of ferrosomes.
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Enhancement of MR angiography with iron oxide: preliminary studies in whole-blood phantom and in animals.
AJR Am J Roentgenol. 1994;162(1):209-13 - PMID: 8273667 - DOI: 10.2214/ajr.162.1.8273667
Detection of pulmonary emboli by using MR angiography with MPEG-PL-GdDTPA: an experimental study in rabbits.
AJR Am J Roentgenol. 1994;162(5):1041-6 - PMID: 8165978 - DOI: 10.2214/ajr.162.5.8165978
T2-weighted MR imaging of the upper part of the abdomen: should fat suppression be used routinely?
AJR Am J Roentgenol. 1994;162(5):1095-100 - PMID: 8165989 - DOI: 10.2214/ajr.162.5.8165989
MR imaging of the peripheral nervous system.
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Dynamic gadolinium-enhanced echo-planar MR imaging of the liver: effect of pulse sequence and dose on enhancement.
J Magn Reson Imaging. 1994;4(3):331-5 - PMID: 8061430 - DOI: 10.1002/jmri.1880040318
Delivery of virus-sized iron oxide particles to rodent CNS neurons.
Neurosurgery. 1994;34(4):777-84 - PMID: 8008188 - DOI: 10.1227/00006123-199404000-00048
A new macromolecule as a contrast agent for MR angiography: preparation, properties, and animal studies.
Radiology. 1993;187(3):701-6 - PMID: 8497616 - DOI: 10.1148/radiology.187.3.8497616
AUR Memorial Award 1993. A drug system (PDH) for interventional radiology. Synthesis, properties, and efficacy.
Invest Radiol. 1993;28(12):1083-9 - PMID: 8307710 - DOI: 10.1097/00004424-199312000-00001
MR imaging of slow axonal transport in vivo.
Exp Neurol. 1993;123(2):235-42 - PMID: 8405287 - DOI: 10.1006/exnr.1993.1156
Monocrystalline iron oxide nanocompounds (MION): physicochemical properties.
Magn Reson Med. 1993;29(5):599-604 - PMID: 8505895 - DOI: 10.1002/mrm.1910290504
Polymeric contrast agents for MR imaging of adrenal glands.
J Magn Reson Imaging. 1993;3(1):93-7 - PMID: 8428107 - DOI: 10.1002/jmri.1880030116
Iron oxide based magnetopharmaceuticals for MR imaging
Eur J Radiol. 1993;3:198-212
MION-ASF: biokinetics of an MR receptor agent.
Magn Reson Imaging. 1993;11(3):411-7 - PMID: 7685055 - DOI: 10.1016/0730-725x(93)90074-n
Antimyosin-labeled monocrystalline iron oxide allows detection of myocardial infarct: MR antibody imaging.
Radiology. 1992;182(2):381-5 - PMID: 1732953 - DOI: 10.1148/radiology.182.2.1732953
Receptor-directed contrast agents for MR imaging: preclinical evaluation with affinity assays.
Radiology. 1992;182(2):565-9 - PMID: 1732982 - DOI: 10.1148/radiology.182.2.1732982
Animal models for magnetic resonance imaging research of the liver.
Invest Radiol. 1992;27(5):390-3 - PMID: 1582824 - DOI: 10.1097/00004424-199205000-00014
Pharmaceutical iron oxides for MR imaging
J Magn Reson Imaging. 1992;4:1-6
Dynamic signal intensity changes in liver with superparamagnetic MR contrast agents.
J Magn Reson Imaging. 1992;2(2):177-81 - PMID: 1562768 - DOI: 10.1002/jmri.1880020210
Contrast agents for magnetic resonance imaging of the liver.
Targeted Diagn Ther. 1992;4:163-87 - PMID: 1797156
Drug targeting in magnetic resonance imaging.
Magn Reson Q. 1992;8(1):55-63 - PMID: 1567758
Lymph nodes: microstructural anatomy at MR imaging.
Radiology. 1991;178(2):519-22 - PMID: 1987619 - DOI: 10.1148/radiology.178.2.1987619
Asialoglycoprotein receptor function in benign liver disease: evaluation with MR imaging.
Radiology. 1991;178(3):769-74 - PMID: 1994416 - DOI: 10.1148/radiology.178.3.1994416
Bone marrow: ultrasmall superparamagnetic iron oxide for MR imaging.
Radiology. 1991;179(2):529-33 - PMID: 2014305 - DOI: 10.1148/radiology.179.2.2014305
Experimental hepatocellular carcinoma: MR receptor imaging.
Radiology. 1991;180(3):641-5 - PMID: 1871273 - DOI: 10.1148/radiology.180.3.1871273
Polyclonal human immunoglobulin G labeled with polymeric iron oxide: antibody MR imaging.
Radiology. 1991;181(1):245-9 - PMID: 1887040 - DOI: 10.1148/radiology.181.1.1887040
Target-specific superparamagnetic MR contrast agents.
Magn Reson Med. 1991;22(2):209-12; discussion 213-5 - PMID: 1812348 - DOI: 10.1002/mrm.1910220209
Mediastinal thymolipoma.
AJR Am J Roentgenol. 1991;157(3):468 - PMID: 1872228 - DOI: 10.2214/ajr.157.3.1872228
Radiation-induced osteochondroma.
AJR Am J Roentgenol. 1991;157(4):792 - PMID: 1892038 - DOI: 10.2214/ajr.157.4.1892038
Clinical application of superparamagnetic iron oxide to MR imaging of tissue perfusion in vascular liver tumors.
Radiology. 1990;174(2):361-6 - PMID: 2296646 - DOI: 10.1148/radiology.174.2.2296646
Hepatic cirrhosis and hepatitis: MR imaging enhanced with superparamagnetic iron oxide.
Radiology. 1990;174(3 Pt 1):797-801 - PMID: 2305063 - DOI: 10.1148/radiology.174.3.2305063
Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging.
Radiology. 1990;175(2):489-93 - PMID: 2326474 - DOI: 10.1148/radiology.175.2.2326474
Ultrasmall superparamagnetic iron oxide: an intravenous contrast agent for assessing lymph nodes with MR imaging.
Radiology. 1990;175(2):494-8 - PMID: 2326475 - DOI: 10.1148/radiology.175.2.2326475
First clinical trial of a new superparamagnetic iron oxide for use as an oral gastrointestinal contrast agent in MR imaging.
Radiology. 1990;175(3):695-700 - PMID: 2343116 - DOI: 10.1148/radiology.175.3.2343116
Receptor imaging: application to MR imaging of liver cancer.
Radiology. 1990;177(3):729-34 - PMID: 2243978 - DOI: 10.1148/radiology.177.3.2243978
The differential diagnosis of ringed hepatic lesions in MR imaging.
AJR Am J Roentgenol. 1990;154(2):287-90 - PMID: 2153330 - DOI: 10.2214/ajr.154.2.2153330
Detection of hepatic metastases: comparison of contrast-enhanced CT, unenhanced MR imaging, and iron oxide-enhanced MR imaging.
AJR Am J Roentgenol. 1990;155(4):763-70 - PMID: 2119106 - DOI: 10.2214/ajr.155.4.2119106
MR receptor imaging: ultrasmall iron oxide particles targeted to asialoglycoprotein receptors.
AJR Am J Roentgenol. 1990;155(6):1161-7 - PMID: 2122660 - DOI: 10.2214/ajr.155.6.2122660
Interstitial lymphangiography: initial clinical experience with a dimeric nonionic contrast agent.
Radiology. 1989;170(2):371-4 - PMID: 2911660 - DOI: 10.1148/radiology.170.2.2911660
Central scars in primary liver tumors: MR features, specificity, and pathologic correlation.
Radiology. 1989;171(2):323-6 - PMID: 2539605 - DOI: 10.1148/radiology.171.2.2539605
Short TI inversion-recovery imaging of the liver: pulse-sequence optimization and comparison with spin-echo imaging.
Radiology. 1989;171(2):327-33 - PMID: 2704797 - DOI: 10.1148/radiology.171.2.2704797
Experimental lymph node metastases: enhanced detection with MR lymphography.
Radiology. 1989;171(3):835-9 - PMID: 2717761 - DOI: 10.1148/radiology.171.3.2717761
The lymphatic system: diagnostic imaging studies.
Radiology. 1989;172(2):315-7 - PMID: 2748809 - DOI: 10.1148/radiology.172.2.2748809
Superparamagnetic iron oxide-enhanced MR imaging: pulse sequence optimization for detection of liver cancer.
Radiology. 1989;172(2):393-7 - PMID: 2748820 - DOI: 10.1148/radiology.172.2.2748820
Primary liver tumors: diagnosis by MR imaging.
AJR Am J Roentgenol. 1989;152(1):63-72 - PMID: 2535770 - DOI: 10.2214/ajr.152.1.63
Superparamagnetic iron oxide: pharmacokinetics and toxicity.
AJR Am J Roentgenol. 1989;152(1):167-73 - PMID: 2783272 - DOI: 10.2214/ajr.152.1.167
The diagnosis of splenic lymphoma by MR imaging: value of superparamagnetic iron oxide.
AJR Am J Roentgenol. 1989;152(1):175-80 - PMID: 2783273 - DOI: 10.2214/ajr.152.1.175
MR imaging of liver neoplasms.
AJR Am J Roentgenol. 1989;152(3):493-9 - PMID: 2536996 - DOI: 10.2214/ajr.152.3.493
Detection of hepatic metastases with MR imaging: spin-echo vs phase-contrast pulse sequences at 0.6 T.
AJR Am J Roentgenol. 1989;153(6):1207-11 - PMID: 2683677 - DOI: 10.2214/ajr.153.6.1207
MRI of hepatic lymphoma.
Magn Reson Imaging. 1989;6(6):675-81 - PMID: 3062298 - DOI: 10.1016/0730-725x(88)90092-6
Hepatic metastases: rat models for imaging research.
Magn Reson Imaging. 1989;7(1):1-8 - PMID: 2918813 - DOI: 10.1016/0730-725x(89)90318-4
Magnetic resonance imaging of liver tumors.
Semin Ultrasound CT MR. 1989;10(1):63-77 - PMID: 2560665
Physical principles of magnetic resonance imaging
Rev Mex Radiol. 1989;43:3-12
Magnetic resonance imaging of the liver.
Magn Reson Q. 1989;5(2):97-121 - PMID: 2701280
Splenic lymphoma: ferrite-enhanced MR imaging in rats.
Radiology. 1988;166(2):423-30 - PMID: 3336717 - DOI: 10.1148/radiology.166.2.3336717
Hepatic micrometastases in the rat: ferrite-enhanced MR imaging.
Radiology. 1988;167(1):21-4 - PMID: 3347724 - DOI: 10.1148/radiology.167.1.3347724
Lymphedema: evaluation of qualitative and quantitative lymphoscintigraphy in 238 patients.
Radiology. 1988;167(3):729-35 - PMID: 3363131 - DOI: 10.1148/radiology.167.3.3363131
Superparamagnetic iron oxide: clinical application as a contrast agent for MR imaging of the liver.
Radiology. 1988;168(2):297-301 - PMID: 3393649 - DOI: 10.1148/radiology.168.2.3393649
Superparamagnetic iron oxide: enhanced detection of focal splenic tumors with MR imaging.
Radiology. 1988;169(2):399-403 - PMID: 3174987 - DOI: 10.1148/radiology.169.2.3174987
MR imaging of focal splenic tumors.
AJR Am J Roentgenol. 1988;150(4):823-7 - PMID: 3279735 - DOI: 10.2214/ajr.150.4.823
Dual-contrast MR imaging of liver cancer in rats.
AJR Am J Roentgenol. 1988;150(3):561-6 - PMID: 3257610 - DOI: 10.2214/ajr.150.3.561
Differentiation of hepatic metastases from hepatic hemangiomas and cysts by using MR imaging.
AJR Am J Roentgenol. 1988;151(1):79-84 - PMID: 3259825 - DOI: 10.2214/ajr.151.1.79
Cholecystitis: diagnosis by MR imaging.
Magn Reson Imaging. 1988;6(3):345-8 - PMID: 3398743 - DOI: 10.1016/0730-725x(88)90412-2
[Magnetic resonance tomography of focal liver and spleen lesions. Experiences using ferrite, a new RES-specific MR contrast medium]
Radiologe. 1988;28(8):380-6 - PMID: 3174975
Lupus nephritis: classification, clinical features, and treatment.
1988;39(3):263-76 - PMID: 3324251
Pyogenic liver abscess: contrast-enhanced MR imaging in rats.
1988;150(1):115-20 - PMID: 3257107 - DOI: 10.2214/ajr.150.1.115
Amebic liver abscess: diagnosis and treatment evaluation with MR imaging.
Radiology. 1987;165(3):795-800 - PMID: 2891154 - DOI: 10.1148/radiology.165.3.2891154
Limb girdle type muscular dystrophy associated with a Wolff-Parkinson-White syndrome.
J Neurol Neurosurg Psych. 1987;50(4):500-1 - PMID: 3585373 - PMCID: PMC1031899 - DOI: 10.1136/jnnp.50.4.500
MR imaging of splenic metastases: ferrite-enhanced detection in rats.
AJR Am J Roentgenol. 1987;149(4):723-6 - PMID: 3498320 - DOI: 10.2214/ajr.149.4.723
Sonographic diagnosis of subclavian and internal jugular vein thrombosis.
J Ultrasound Med. 1987;6(10):577-87 - PMID: 3316690 - DOI: 10.7863/jum.1987.6.10.577
Lupus nephritis: Classification, clinical features and treatment
Rev Invest Clin. 1987;39:263-276
Ferrite-enhanced MR imaging of hepatic lymphoma: an experimental study in rats.
1987;149(6):1161-5 - PMID: 3318339 - DOI: 10.2214/ajr.149.6.1161
After loading therapy with Cs-137 for cervical cancer: Evaluation of the first 117 patients treated
1986;32:147-153
Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene function in gliomagenesis
Proc Natl Acad Sci U S A. 0;:ePub
Peroxidase substrate nanosensors for MR imaging
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