Treatment of obesity with celastrol.
Recent Developments in Magnetic Diagnostic Systems
Intravascular fibrin molecular imaging improves the detection of unhealed stents assessed by optical coherence tomography in vivo.
Eur Heart J. 2015;38(6):447-455 - PMID: 26685129 - PMCID: PMC5837565 - DOI: 10.1093/eurheartj/ehv677
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
Sci Transl Med. 2015;7(288):288ra77 - PMID: 25995223 - PMCID: PMC4675670 - DOI: 10.1126/scitranslmed.aaa3575
Characterizing the Interactions of Organic Nanoparticles with Renal Epithelial Cells in Vivo.
Imaging Granzyme B Activity Assesses Immune-Mediated Myocarditis.
Circ Res. 2015;117(6):502-12 - PMID: 26199323 - PMCID: PMC4553143 - DOI: 10.1161/CIRCRESAHA.115.306364
Blood Accessibility to Fibrin in Venous Thrombosis is Thrombus Age-Dependent and Predicts Fibrinolytic Efficacy: An In Vivo Fibrin Molecular Imaging Study.
Bioorthogonal Click Chemistry-Based Synthetic Cell Glue.
The use of (18)F-2-fluorodeoxyglucose (FDG) to label antibody fragments for immuno-PET of pancreatic cancer.
ACS Cent Sci. 2015;1(3):142-147 - PMID: 26955657 - PMCID: PMC4778250 - DOI: 10.1021/acscentsci.5b00121
Bioorthogonal Radiopaque Hydrogel for Endoscopic Delivery and Universal Tissue Marking.
Adv Healthc Mater. 2015;5(4):421-426 - PMID: 26688173 - PMCID: PMC4811597 - DOI: 10.1002/adhm.201500780
Versatile click alginate hydrogels crosslinked via tetrazine-norbornene chemistry.
Biomaterials . 2015;50:30-7 - PMID: 25736493 - DOI: 10.1016/j.biomaterials.2015.01.048
Advances in measuring single-cell pharmacokinetics and pharmacology in vivo.
Drug Discov Today. 2015;20(9):1087-92 - PMID: 26024776 - PMCID: PMC4567932 - DOI: 10.1016/j.drudis.2015.05.011
Fluorescence polarization-based nucleic acid testing for rapid and cost-effective diagnosis of infectious disease
HDAC6 Inhibitors Modulate Lys49 Acetylation and Membrane Localization of β-Catenin in Human iPSC-Derived Neuronal Cells.
Rapid, high efficiency isolation of pancreatic ß-cells
Tailoring Adjuvant Radiation Therapy by Intraoperative Imaging to Detect Residual Cancer.
Semin Radiat Oncol. 2015;25(4):313-21 - PMID: 26384279 - PMCID: PMC4575408 - DOI: 10.1016/j.semradonc.2015.05.005
Bioorthogonal fluorophore linked DFO - Technology enabling facile chelator quantification and multimodal imaging of antibodies.
Bioconjug Chem. 2015;27(1):257-63 - PMID: 26684717 - PMCID: PMC4858350 - DOI: 10.1021/acs.bioconjchem.5b00630
Nanostar clustering improves the sensitivity of plasmonic assays.
Bioconjug Chem. 2015;26(8):1470-1474 - PMID: 26102604 - PMCID: PMC5292976 - DOI: 10.1021/acs.bioconjchem.5b00343
Optimized Near-IR fluorescent agents for in vivo imaging of Btk expression.
Bioconjug Chem. 2015;26(8):1513-1518 - PMID: 26017814 - PMCID: PMC4772718 - DOI: 10.1021/acs.bioconjchem.5b00152
Nanoparticle Detection of Urinary Markers for Point-of-Care Diagnosis of Kidney Injury.
PLoS ONE. 2015;10(7):e0133417 - PMID: 26186708 - PMCID: PMC4506142 - DOI: 10.1371/journal.pone.0133417
Engineered Trehalose Permeable to Mammalian Cells.
PLoS ONE. 2015;10(6):e0130323 - PMID: 26115179 - PMCID: PMC4482662 - DOI: 10.1371/journal.pone.0130323
Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype.
Eur J Med Chem. 2015;102:320-333 - PMID: 26295174 - DOI: 10.1016/j.ejmech.2015.07.047
Live Cell Multi-Photon Fluorescence Correlation Spectroscopy with an Improved Large Stokes Shift Fluorescent Protein.
Mol Biol Cell. 2015;26(11):2054-66 - PMID: 25877871 - PMCID: PMC4472016 - DOI: 10.1091/mbc.E14-10-1473
Dual-Modality Optical/PET Imaging of PARP1 in Glioblastoma.
Mol Imaging Biol. 2015;17(6):848-55 - PMID: 25895168 - PMCID: PMC4609241 - DOI: 10.1007/s11307-015-0858-0
Inhibition of histone deacetylase 6 improves long-term survival in a lethal septic model.
J Trauma Acute Care Surg. 2015;78(2):378-85 - PMID: 25757125 - PMCID: PMC4357277 - DOI: 10.1097/TA.0000000000000510
Photocleavable DNA Barcoding Antibodies for Multiplexed Protein Analysis in Single Cells.
Methods Mol Biol. 2015;1346:47-54 - PMID: 26542714 - DOI: 10.1007/978-1-4939-2987-0_4
Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma.
Acta Neuropathol Commun. 2015;3(1):22 - PMID: 25853389 - PMCID: PMC4382927 - DOI: 10.1186/s40478-015-0201-7
Imaging macrophages with nanoparticles.
Nat Mater. 2014;13(2):125-38 - PMID: 24452356 - DOI: 10.1038/nmat3780
Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin
Sci Transl Med. 2014;6 (261):261ra152 - PMID: 25378644 - PMCID: PMC4330962 - DOI: 10.1126/scitranslmed.3009318
Cancer Cell Profiling by Barcoding Allows Multiplexed Protein Analysis in Fine-Needle Aspirates
Sci Transl Med. 2014;6(219):219ra9 - PMID: 24431113 - PMCID: PMC4063286 - DOI: 10.1126/scitranslmed.3007361
Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase (HDAC) Inhibitors by Multimodality Molecular Imaging in Living Subjects.
Cancer Res. 2014;74(24):7475-86 - PMID: 25320008 - PMCID: PMC4315624 - DOI: 10.1158/0008-5472.CAN-14-0197
In vivo imaging of specific drug-target binding at subcellular resolution.
Magnetic Ligation Method for Quantitative Detection of MicroRNAs.
Adv Healthc Mater. 2014;3(7):1015-9 - PMID: 24532323 - PMCID: PMC4107040 - DOI: 10.1002/adhm.201300672
RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis.
Magnetic sensing technology for molecular analyses.
Red Si-rhodamine drug conjugates enable imaging in GFP cells.
Effect of Small Molecule Modification on Single Cell Pharmacokinetics of PARP Inhibitors.
Mol Cancer Ther. 2014;13(4):986-95 - PMID: 24552776 - PMCID: PMC3981972 - DOI: 10.1158/1535-7163.MCT-13-0801
Single cell imaging of Bruton's tyrosine kinase using an irreversible inhibitor.
Imaging cellular distribution of Bcl inhibitors using small molecule drug conjugates.
In Vivo Imaging of GLP-1R with a Targeted Bimodal PET/Fluorescence Imaging Agent.
In Vivo Imaging of Multidrug Resistance Using a Third Generation MDR1 Inhibitor.
Monoalkoxy BODIPYs - A Fluorophore Class for Bioimaging.
Efficient Acid-Catalyzed (18) F/(19) F Fluoride Exchange of BODIPY Dyes.
Platinum Compounds for High-Resolution In Vivo Cancer Imaging.
Chemical Interrogation of the Malaria Kinome.
Imaging Neuroinflammation - from Bench to Bedside.
J Clin Cell Immunol. 2014;5:ePub - PMID: 25525560 - PMCID: PMC4266918 - DOI: 10.4172/2155-9899.1000226
Site-Specific Labeling of Proteins and Peptides with Trans-cyclooctene Containing Handles Capable of Tetrazine Ligation.
Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid-Phase Peptide Synthesis.
Protective effect of suberoylanilide hydroxamic acid against lipopolysaccharide-induced liver damage in rodents.
J Surg Res. 2014;194(2):544-550 - PMID: 25479907 - PMCID: PMC4361238 - DOI: 10.1016/j.jss.2014.10.056
Bioorthogonal Approach to Identify Unsuspected Drug Targets in Live Cells
Angew Chem Int Ed Engl. 2013;52(40):10593-7 - PMID: 23960025 - PMCID: PMC3856564 - DOI: 10.1002/anie.201304096
BODIPY-Tetrazine Derivatives as Superbright Bioorthogonal Turn-on Probes.
Angew Chem Int Ed Engl. 2013;52(27):6917-6920 - PMID: 23712730 - PMCID: PMC3875324 - DOI: 10.1002/anie.201301100
Magnetic Nanosensor for Detection and Profiling of Erythrocyte-Derived Microvesicles.
Polymeric Nanoparticle PET/MR Imaging Allows Macrophage Detection in Atherosclerotic Plaques.
Circ Res. 2013;112(5):755-61 - PMID: 23300273 - PMCID: PMC3586287 - DOI: 10.1161/CIRCRESAHA.111.300576
Magnetic barcode assay for genetic detection of pathogens
Upconverting Organic Dye Doped Core-Shell Nano-Composites for Dual-Modality NIR Imaging and Photo-Thermal Therapy.
Induction of differential apoptotic pathways in multiple myeloma cells by class selective histone deacetylase inhibitors.
Histone deacetylase 3 (HDAC3) as a novel therapeutic target in multiple myeloma.
A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels-Alder Click Chemistry.
J Nucl Med. 2013;54(8):1389-96 - PMID: 23708196 - PMCID: PMC4151562 - DOI: 10.2967/jnumed.112.115840
Molecular characterization of scant lung tumor cells using iron-oxide nanoparticles and micro-nuclear magnetic resonance.
Nanomedicine. 2013;10 :661-668 - PMID: 24200523 - PMCID: PMC3966960 - DOI: 10.1016/j.nano.2013.10.008
A photoactivatable drug–caged fluorophore conjugate allows direct quantification of intracellular drug transport
Targeting cathepsin e in pancreatic cancer by a small molecule allows in vivo detection.
Book review: the handbook of nanomedicine (2nd edition).
Nanomedicine (Lond). 2013;8(2):173-5 - PMID: 23394153
Bioorthogonal Small Molecule Imaging Agents Allow Single-Cell Imaging of MET
PLoS ONE. 2013;8 (11):e81275 - PMID: 24265843 - PMCID: PMC3827223 - DOI: 10.1371/journal.pone.0081275
Microfluidic On-chip Capture-cycloaddition Reaction to Reversibly Immobilize Small Molecules or Multi-component Structures for Biosensor Applications.
Oxidation Kinetics and Magnetic Properties of Elemental Iron Nanoparticles
Part. Part. Syst. Charact. 2013;30:667–671 - PMID: 24077230 - PMCID: PMC3783348 - DOI: 10.1002/ppsc.201300013
Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy
A Magnetic Gram Stain for Bacterial Detection.
Angew Chem Int Ed Engl. 2012;51(31):7752-5 - PMID: 22744868 - PMCID: PMC3496380 - DOI: 10.1002/anie.201202982
Bioorthogonal Imaging of Aurora Kinase A in Live Cells.
Angew Chem Int Ed Engl. 2012;51(27):6598-603 - PMID: 22644700 - PMCID: PMC3523717 - DOI: 10.1002/anie.201200994
Synthesis of [(18) F]BODIPY: Bifunctional Reporter for Hybrid Optical/Positron Emission Tomography Imaging.
Angew Chem Int Ed Engl. 2012;51(19):4603-6 - PMID: 22473535 - PMCID: PMC3343182 - DOI: 10.1002/anie.201107957
Mechanism of Magnetic Relaxation Switching Sensing.
Orthogonal Amplification of Nanoparticles for Improved Diagnostic Sensing.
Over a hump for imaging atherosclerosis: nanobodies visualize vascular cell adhesion molecule-1 in inflamed plaque.
Circ Res. 2012;110(7):902-3 - PMID: 22461358 - DOI: 10.1161/CIRCRESAHA.112.267260
Photocleavable DNA barcode-antibody conjugates allow sensitive and multiplexed protein analysis in single cell.
J Am Chem Soc. 2012;134(45):18499-18502 - PMID: 23092113 - PMCID: PMC3498844 - DOI: 10.1021/ja307689w
Molecular imaging of fibrin deposition in deep vein thrombosis using fibrin-targeted near-infrared fluorescence.
JACC Cardiovasc Imaging. 2012;5(6):607-15 - PMID: 22698530 - PMCID: PMC3376390 - DOI: 10.1016/j.jcmg.2012.01.017
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase
Painting blood vessels and atherosclerotic plaques with an adhesive drug depot.
Proc Natl Acad Sci U S A. 2012;109(52):21444-9 - PMID: 23236189 - PMCID: PMC3535589 - DOI: 10.1073/pnas.1217972110
Reactive polymer enables efficient in vivo bioorthogonal chemistry.
Proc Natl Acad Sci U S A. 2012;109(13):4762-7 - PMID: 22411831 - PMCID: PMC3324005 - DOI: 10.1073/pnas.1113466109
Magnetic Nanoparticles and microNMR for Diagnostic Applications.
Dual Imaging and Photoactivated Nanoprobe for Controlled Cell Tracking.
Cell Sorting: Microfluidic Cell Sorter (μFCS) for On-chip Capture and Analysis of Single Cells
Adv Healthc Mater. 2012;1(4):432-6 - PMID: 23184773 - PMCID: PMC3508764 - DOI: 10.1002/adhm.201200046
Regulation of CD133 by HDAC6 Promotes β-Catenin Signaling to Suppress Cancer Cell Differentiation.
On-chip bioorthogonal chemistry enables immobilization of in situ modified nanoparticles and small molecules for label-free monitoring of protein binding and reaction kinetics.
Inflammation Modulates Murine Venous Thrombosis Resolution In Vivo: Assessment by Multimodal Fluorescence Molecular Imaging.
Arterioscler Thromb Vasc Biol. 2012;32(11):2616-24 - PMID: 22995524 - PMCID: PMC3516622 - DOI: 10.1161/ATVBAHA.112.251983
Sensitive and Direct Detection of Circulating Tumor Cells by Multimarker µ-Nuclear Magnetic Resonance.
Imaging Therapeutic PARP Inhibition In Vivo through Bioorthogonally Developed Companion Imaging Agents
Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity.
ACS Chem Biol. 2012;7(9):1520-8 - PMID: 22724584 - DOI: 10.1021/cb300235m
meso-Arylporpholactones and their Reduction Products.
Crebinostat: A Novel cognitive enhancer that inhibits Histone Deacetylase activity and Modulates Chromatin-mediated Neuroplasticity.
Neuropharmacology. 2012;64(1):81-96 - PMID: 22771460 - PMCID: PMC3447535 - DOI: 10.1016/j.neuropharm.2012.06.043
Characterization of Plasmodium Liver Stage Inhibition by Halofuginone.
Efficient (18)F-Labeling of Synthetic Exendin-4 Analogues for Imaging Beta Cells.
Detection and treatment of intravascular thrombi with magnetofluorescent nanoparticles.
Method Enzymol. 2012;508:191-209 - PMID: 22449927 - DOI: 10.1016/B978-0-12-391860-4.00010-0
Multicore Assemblies Potentiate Magnetic Properties of Biomagnetic Nanoparticles.
Multiplexed Magnetic Labeling Amplification Using Oligonucleotide Hybridization.
Dextran-Coated Iron Oxide Nanoparticles: A Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy.
Biomedical Applications of Tetrazine Cycloadditions.
The effect of selective inhibition of HDAC6 with ACY1215 on bortezomib activity in multiple myeloma (MM).
J Clin Oncol. 2011;29(15_suppl):e18569 - PMID: 28023028
Bioorthogonal Reaction Pairs Enable Simultaneous, Selective, Multi-Target Imaging.
Angew Chem Int Ed Engl. 2011;51(4):920-2 - PMID: 22162316 - PMCID: PMC3304098 - DOI: 10.1002/anie.201104389
Supramolecular Host-Guest Interaction for Labeling and Detection of Cellular Biomarkers.
Angew Chem Int Ed Engl. 2011;51(2):450-4 - PMID: 22113923 - PMCID: PMC3309171 - DOI: 10.1002/anie.201105670
Bioorthogonal Probes for Polo-like Kinase 1 Imaging and Quantification.
Angew Chem Int Ed Engl. 2011;50(40):9378-81 - PMID: 21948435 - PMCID: PMC3187564 - DOI: 10.1002/anie.201103273
Highly magnetic core-shell nanoparticles with a unique magnetization mechanism.
Angew Chem Int Ed Engl. 2011;50(20):4663-6 - PMID: 21495138 - PMCID: PMC3334859 - DOI: 10.1002/anie.201100101
Synthesis and In Vivo Imaging of a (18) F-Labeled PARP1 Inhibitor Using a Chemically Orthogonal Scavenger-Assisted High-Performance Method.
Angew Chem Int Ed Engl. 2011;50(8):1922-5 - PMID: 21328671 - PMCID: PMC3471140 - DOI: 10.1002/anie.201006579
Ubiquitous Detection of Gram-Positive Bacteria with Bioorthogonal Magnetofluorescent Nanoparticles.
Nanoparticle Mediated Measurement of Target-Drug Binding in Cancer Cells.
Probing Intracellular Biomarkers and Mediators of Cell Activation Using Nanosensors and Bioorthogonal Chemistry.
Helimeric Porphyrinoids: Stereostructure and Chiral Resolution of meso-Tetraarylmorpholinochlorins.
J Am Chem Soc. 2011;133(22):8740-8752 - PMID: 21534626 - DOI: 10.1021/ja202451t
Synapse microarray identification of small molecules that enhance synaptogenesis.
Accurate measurement of pancreatic islet {beta}-cell mass using a second-generation fluorescent exendin-4 analog.
Proc Natl Acad Sci U S A. 2011;108(31):12815-20 - PMID: 21768367 - PMCID: PMC3150928 - DOI: 10.1073/pnas.1109859108
In Vivo PET-imaging of Histone Deacetylases by 18F-Suberoylanilide Hydroxamic Acid (18F-SAHA).
Identification and Validation of Tetracyclic Benzothiazepines as Plasmodium falciparum Cytochrome bc(1) Inhibitors.
Chem Biol. 2011;18(12):1602-10 - PMID: 22195562 - PMCID: PMC3474356 - DOI: 10.1016/j.chembiol.2011.09.016
The role of nanomedicine in the imaging and therapy of thrombosis.
Nanomedicine (Lond). 2011;6(8):1291-3 - PMID: 22026372 - PMCID: PMC3332076 - DOI: 10.2217/nnm.11.128
Facile Synthesis of Monofunctional Pentamethine Carbocyanine Fluorophores.
Dyes Pigm. 2011;90(2):119-122 - PMID: 21475610 - PMCID: PMC3070263 - DOI: 10.1016/j.dyepig.2010.12.008
Specific Pathogen Detection Using Bioorthogonal Chemistry and Diagnostic Magnetic Resonance.
89Zr Labeled Dextran Nanoparticles Enable in vivo Macrophage Imaging.
Synthesis and Evaluation of a Series of 1,2,4,5-Tetrazines for Bioorthogonal Conjugation.
A Modular Strategy for the Construction of Radiometallated Antibodies for Positron Emission Tomography Based on Inverse Electron Demand Diels-Alder Click Chemistry.
High-Yielding, Two-Step (18) F Labeling Strategy for (18) F-PARP1 Inhibitors.
Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells.
Leuk Lymphoma. 2011;52(8):1544-55 - PMID: 21699378 - PMCID: PMC4113006 - DOI: 10.3109/10428194.2011.570821
Microarray profiling reveals the Integrated Stress Response is activated by Halofuginone in mammary epithelial cells.
Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection
Bioorthogonal Turn-On Probes for Imaging Small Molecules inside Living Cells.
Angew Chem Int Ed Engl. 2010;19 (49):2869-2872 - PMID: 20306505 - PMCID: PMC3433403 - DOI: 10.1002/anie.200906120
Quantitative Nanostructure-Activity Relationship Modeling.
Multifunctional agents for concurrent imaging and therapy in cardiovascular disease.
Adv Drug Deliv Rev. 2010;62(11):1023-30 - PMID: 20654664 - PMCID: PMC2974776 - DOI: 10.1016/j.addr.2010.07.004
Chemical phylogenetics of histone deacetylases.
A Light-Activated Theranostic Nanoagent for Targeted Macrophage Ablation in Inflammatory Atherosclerosis.
Targeted nanoagents for the detection of cancers.
Mol Oncol. 2010;4(6):511-28 - PMID: 20851695 - PMCID: PMC2981649 - DOI: 10.1016/j.molonc.2010.08.003
A Concise Silylamine Approach to 2-Amino-3-hydroxy-indoles with Potent in vivo Antimalaria Activity.
Binding Affinity and Kinetic Analysis of Targeted Small Molecule-Modified Nanoparticles
Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.
On the inhibition of histone deacetylase 8.
Bioorg Med Chem. 2010;18(11):4103-4110 - PMID: 20472442 - PMCID: PMC3245874 - DOI: 10.1016/j.bmc.2010.03.080
Magnetic nanoparticles for biomedical NMR-based diagnostics
Beilstein J Nanotechnol. 2010;1:142154 - PMID: 21977404 - PMCID: PMC3045933 - DOI: 10.3762/bjnano.1.17
Nanoparticle-Target Interactions Parallel Antibody-Protein Interactions.
A screening paradigm for the design of improved polymer-coated superparamagnetic iron oxide nanoparticles
J Mater Chem. 2009;19:6387-6392
High-Throughput Screen for Novel Antimicrobials using a Whole Animal Infection Model.
Multimodal Nanoagents for the Detection of Intravascular Thrombi.
Labels and probes for live cell imaging: overview and selection guide.
Methods Mol Biol. 2009;591:17-45 - PMID: 19957122 - DOI: 10.1007/978-1-60761-404-3_2
One-Pot Synthesis of New Symmetric and Asymmetric Xanthene Dyes.
Tetrahedron Lett. 2007;48(25):4383-4385 - PMID: 19834587 - PMCID: PMC2761723 - DOI: 10.1016/j.tetlet.2007.04.088
Chemical and Genetic Sensors in Biomedical Research.
J Biomed Opt. 2005;10(4):41201 - PMID: 23171967
Magnetic Nanosensors for the Detection of Oligonucleotide Sequences.
Angew Chem Int Ed Engl. 2001;40(17):3204-3206 - PMID: 29712059 - DOI: 10.1002/1521-3773(20010903)40:17<3204::AID-ANIE3204>3.0.CO;2-H
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