Chemistry Platform

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Chemistry Platform

The chemical biology platform enables the use of chemical probes to understand biologic pathways and phenotype cellular states in health and disease. These probes may be directed at validated disease targets, or applied in a "forward genetic" approach that is systematic and less dependent on a priori assumptions. Platform activities encompass three interrelated efforts: 1) Synthetic chemistry, including the creation of novel small molecules, diversity oriented synthesis (DOS) and other libraries; 2) High-throughput screening and analysis, utilizing a variety of biochemical, metabolic, and high-content imaging measurements and 3) a Chemistry Core for the production and quality control of imaging probes that are not commercially available.

Chem_platform
Ralph Mazitschek, PhD (Synthesis)
Jason McCarthy, PhD (Core)
Ned Keliher, PhD (Radiochemistry)
Jonathan Carlson, MD,PhD (Analytical Chemistry)

Recent Publications (more...)

Kakkar A, Traverso G, Farokhzad OC, Weissleder R, Langer R
Evolution of macromolecular complexity in drug delivery systems
Nat Rev Chem. 2017;1:0063
Miller MA, Weissleder R
Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior
Adv Drug Deliv Rev. 2017;113:61-86
Miller MA, Askevold B, Mikula H, Kohler RH, Pirovich D, Weissleder R
Nano-palladium is a cellular catalyst for in vivo chemistry
Nat Commun. 2017;8:15906 - PMID: 28699627 - PMCID: PMC5510178
Vunnam S, Mazitschek R, Kariem NM, Reddy A, Rabeh W, Li L, O'Connor MJ, Al-Tel TH
Modular Bi-Directional One-Pot Strategies for the Diastereoselective Synthesis of Structurally Diverse Collections of Constrained β-Carboline-Benzoxazepines.
Chemistry. 2017;:ePub - PMID: 28770556

Recent News (more...)

2016-12-02: Ralph Mazitschek, PhD received new patent for Compounds for Treating Infectious Diseases. Susan Lindquist, Catherine McLellan and Luke Whitesell, MD were co-inventors.
2013-07-15: ChemistryViews.org highlights CSB paper on the Fastest and the Brightest Fluorescent Probe based on BODIPY-Tz components.
2013-05-23: Novel imaging probe platform developed at CSB enables imaging - "BODIPY–Tetrazine Derivatives as Superbright Bioorthogonal Turn-on Probes"
2012-02-13: "Secrets of ancient Chinese remedy revealed" - Harvard Gazette features latest work from Dr. Mazitschek. (pdf). It is also on the Top 10 Chart in Nature Chemical Biology (pdf)