Chemistry Program
The chemistry program enables the use of chemical probes to understand biologic pathways and phenotype cellular states in health and disease. These probes may be directed at validated disease targets, or applied in a "forward genetic" approach that is systematic and less dependent on a priori assumptions. Platform activities encompass three interrelated efforts: 1) Synthetic chemistry, including the creation of novel small molecules, diversity oriented synthesis (DOS) and other libraries; 2) High-throughput screening and analysis, utilizing a variety of biochemical, metabolic, and high-content imaging measurements and 3) a Chemistry Core for the production and quality control of imaging probes that are not commercially available.
Recent Publications
Enbergs N*, Halabi EA*, Goubet AG, Schleyer K, Fredrich IR, Kohler RH, Garris CS, Pittet MJ, Weissleder R Pharmacological Polarization of Tumor-Associated Macrophages Toward a CXCL9 Antitumor Phenotype. Adv Sci (Weinh). 2024;11(15):e2309026 - PMID: 38342608 - PMCID: PMC11022742 - DOI: 10.1002/advs.202309026
Ichikawa S, Payne NC, Xu W, Chang CF, Vallavoju N, Frome S, Flaxman HA, Mazitschek R, Woo CM The cyclimids: Degron-inspired cereblon binders for targeted protein degradation. Cell Chem Biol. 2024;:ePub - PMID: 38320555 - DOI: 10.1016/j.chembiol.2024.01.003
Carrow KP, Hamilton HL, Hopps MP, Li Y, Qiao B, Payne NC, Thompson MP, Zhang X, Magassa A, Fattah M, Agarwal S, Vincent MP, Buyanova M, Bertin PA, Mazitschek R, Olvera de la Cruz M, Johnson DA, Johnson JA, Gianneschi NC Inhibiting the Keap1/Nrf2 Protein-Protein Interaction with Protein-Like Polymers. Adv Mater. 2024;:e2311467 - PMID: 38241649 - DOI: 10.1002/adma.202311467
Rosenthal ZC, Fass DM, Payne NC, She A, Patnaik D, Hennig KM, Tesla R, Werthmann GC, Guhl C, Reis SA, Wang X, Chen Y, Placzek M, Williams NS, Hooker J, Herz J, Mazitschek R, Haggarty SJ Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia. Sci Rep. 2024;14(1):9064 - PMID: 38643236 - PMCID: PMC11032351 - DOI: 10.1038/s41598-024-59110-7
- More publications ...
News
Kritika Singh (Mazitschek Lab), a bioengineering and chemistry student at Northeastern who has dedicated herself to tackling global health issues, has been named a 2020 Rhodes Scholar, considered the most prestigious academic honor for U.S. college students. Congratulations, Kritika!
Ralph Mazitschek, PhD received new patent for Compounds for Treating Infectious Diseases. Susan Lindquist, Catherine McLellan and Luke Whitesell, MD were co-inventors.
ChemistryViews.org highlights CSB paper on the Fastest and the Brightest Fluorescent Probe based on BODIPY-Tz components.
Novel imaging probe platform developed at CSB enables imaging - "BODIPY–Tetrazine Derivatives as Superbright Bioorthogonal Turn-on Probes"
"Secrets of ancient Chinese remedy revealed" - Harvard Gazette features latest work from Dr. Mazitschek. (pdf). It is also on the Top 10 Chart in Nature Chemical Biology (pdf)