Chemistry Platform

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Chemistry Platform

The chemical biology platform enables the use of chemical probes to understand biologic pathways and phenotype cellular states in health and disease. These probes may be directed at validated disease targets, or applied in a "forward genetic" approach that is systematic and less dependent on a priori assumptions. Platform activities encompass three interrelated efforts: 1) Synthetic chemistry, including the creation of novel small molecules, diversity oriented synthesis (DOS) and other libraries; 2) High-throughput screening and analysis, utilizing a variety of biochemical, metabolic, and high-content imaging measurements and 3) a Chemistry Core for the production and quality control of imaging probes that are not commercially available.

Chem_platform
Ralph Mazitschek, PhD (Synthesis)
Jason McCarthy, PhD (Core)
Ned Keliher, PhD (Radiochemistry)
Jonathan Carlson, MD,PhD (Analytical Chemistry)

Recent Publications (more...)

Dubach JM, Kim E, Yang K, Cuccarese M, Giedt RJ, Meimetis LG, Vinegoni C, Weissleder R
Quantitating drug-target engagement in single cells in vitro and in vivo.
Nat Chem Biol. 2016;13(2):168-173 - PMID: 27918558
Hideshima T, Qi J, Paranal RM, Tang W, Greenberg E, West N, Colling ME, Estiu G, Mazitschek R, Perry JA, Ohguchi H, Cottini F, Mimura N, Görgün G, Tai YT, Richardson PG, Carrasco RD, Wiest O, Schreiber SL, Anderson KC, Bradner JE
Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma.
Proc Natl Acad Sci U S A. 2016;113(46):13162-13167 - PMID: 27799547 - PMCID: PMC5135369
Hong S, Pirovich D, Kilcoyne A, Huang CH, Lee H, Weissleder R
Supramolecular Metallo-Bioadhesive for Minimally Invasive Use
Adv Mater. 2016;28(39):8675-8680 - PMID: 27515068 - PMCID: PMC5144581
Hong S, Park KS, Weissleder R, Castro CM, Lee H
Facile silicification of plastic surface for bioassays.
Chem Commun. 2017;53(13):2134-2137 - PMID: 28134385

Recent News (more...)

2016-12-02: Ralph Mazitschek, PhD received new patent for Compounds for Treating Infectious Diseases. Susan Lindquist, Catherine McLellan and Luke Whitesell, MD were co-inventors.
2013-07-15: ChemistryViews.org highlights CSB paper on the Fastest and the Brightest Fluorescent Probe based on BODIPY-Tz components.
2013-05-23: Novel imaging probe platform developed at CSB enables imaging - "BODIPY–Tetrazine Derivatives as Superbright Bioorthogonal Turn-on Probes"
2012-02-13: "Secrets of ancient Chinese remedy revealed" - Harvard Gazette features latest work from Dr. Mazitschek. (pdf). It is also on the Top 10 Chart in Nature Chemical Biology (pdf)