Vinegoni Lab

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Phone: (617) 643-6137

The current research activity involves the development of novel optical mesoscopic molecular imaging techniques that allow to generate in-vivo three-dimensional data in optically diffusive non-transparent living organisms with a size up to a few millimeters (e.g. Drosophila Melanogaster, Zebrafish) providing both in-vivo anatomical and functional imaging. At the same time we are committed into the development of new fluorescence molecular tomography (FMT) techniques in diffusive regime for whole mouse imaging. Other research activities involve in vivo near infrared fluorescence imaging of protease activity in rabbit models of atherosclerosis and the development of novel fiber based imaging systems, and the development of combined optical and opto-acoustic multispectral tomographic imaging for in-vivo imaging applications.

Recent Publications

  • Pulous FE, Cruz-Hernandez JC, Yang C, Kaya Z, Paccalet A, Wojtkiewicz G, Capen D, Brown D, Wu JW, Schloss MJ, Vinegoni C, Richter D, Yamazoe M, Hulsmans M, Momin N, Grune J, Rohde D, McAlpine CS, Panizzi P, Weissleder R, Kim DE, Swirski FK, Lin CP, Moskowitz MA, Nahrendorf M Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis. Nat Neurosci. 2022;25(5):567-576 - PMID: 35501382 - PMCID: PMC9081225 - DOI: 10.1038/s41593-022-01060-2

  • Rohde D, Vandoorne K, Lee IH, Grune J, Zhang S, McAlpine CS, Schloss MJ, Nayar R, Courties G, Frodermann F, Wojtkiewicz G, Honold L, Chen Q, Schmidt S, Iwamoto Y, Sun Y, Cremer S, Hoyer FF, Iborra-Egea O, Muñoz-Guijosa C, Fei Ji F, Zhou B, Adams RH, Wythe JD, Hidalgo J, Watanabe H, Jung Y, van der Laan AM, Piek JJ, Kfoury Y, Désogère PA, Vinegoni C, Dutta P, Sadreyev RI, Caravan P, Bayes-Genis A, Libby P, Scadden DT, Lin CP Naxerova K, Swirski FK, Nahrendorf M Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease. Nature Cardiovascular Research. 2022;1:28–44 - DOI: 10.1038/s44161-021-00002-8

  • McAlpine CS, Park J, Griciuc A, Kim E, Choi SH, Iwamoto Y, Kiss MG, Christie KA, Vinegoni C, Poller WC, Mindur JE, Chan CT, He S, Janssen H, Wong LP, Downey J, Singh S, Anzai A, Kahles F, Jorfi M, Feruglio PF, Sadreyev RI, Weissleder R, Kleinstiver BP, Nahrendorf M, Tanzi RE, Swirski FK Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease. Nature. 2021;595(7869):701-706 - PMID: 34262178 - PMCID: PMC8934148 - DOI: 10.1038/s41586-021-03734-6

  • Bachar Issa TH, Vinegoni C, Shaw A, Fumene Feruglio P, Weissleder R, Uminsky D Video-Rate Acquisition Fluorescence Microscopy via Generative Adversarial Networks. EasyChair. 2020;:ePub

  • Min J*, Chin LK*, Oh J, Landeros C, Vinegoni C, Lee J, Lee SJ, Park JY, Liu AQ, Castro CM, Lee H, Im H, Weissleder R CytoPAN—Portable cellular analyses for rapid point-of-care cancer diagnosis. Sci Transl Med. 2020;12:eaaz9746 - PMID: 32759277 - PMCID: PMC8217912 - DOI: 10.1126/scitranslmed.aaz9746

  • More publications ...

Research projects

Other macro and mesoscopic imaging technique are pursued such as Born normalized Optical Projection Tomography with molecular contrast for ex-vivo small animal and whole organ imaging. This technique provides detailed tomographic reconstruction of morphology and molecular probes within tissue with resolution up to 5 microns in entire organs (e.g. heart, brain, kidney, etc) and can complement in-vivo imaging techniques such as FMT and MPM.

We are developing new applications for novel microscopy imaging systems and design and conduct cutting-edge experiments. In particular we are interested in providing new techniques for motion compensation for multiphoton microscopy in order to avoid artifacts due to respiratory and cardiac motion. Both hardware and software based approaches are conducted.



CSB has been named as one of the NCI Innovative Research in Cancer Nanotechnology (IRCNs). The IRCNs engage in directed, product-focused research that aims to translate cutting-edge science and technology into the next generation of diagnostic and therapeutic tools. These platforms serve as the core technologies for a wide array of specific applications that will ultimately benefit cancer patients.


Dont forget to register for the upcoming Harvard CME course on Molecular Imaging. The course is being chaired by Drs. Frangioni and Weissleder and features over 30 invited speakers covering all topics of molecular imaging. More information can be found here.