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CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers.
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Dendritic cells as shepherds of T cell immunity in cancer.
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Tumor-infiltrating dendritic cell states are conserved across solid human cancers.
Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy.
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Versatile neutrophil functions in cancer.
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Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy.
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Myeloid cells are enriched in tonsillar crypts providing insight into the host tropism of HPV.
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Diagnostic challenges and successful organ-preserving therapy in a case of secretory carcinoma of minor salivary glands.
The expanding landscape of inflammatory cells affecting cancer therapy
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Durable and controlled depletion of neutrophils in mice.
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Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma.
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Myeloid Cell-Targeted Nanocarriers Efficiently Inhibit Cellular Inhibitor of Apoptosis for Cancer Immunotherapy.
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Tumor-Promoting Ly-6G+ SiglecFhigh Cells Are Mature and Long-Lived Neutrophils.
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Single Extracellular Vesicle Protein Analysis Using Immuno-Droplet Digital Polymerase Chain Reaction Amplification.
Single Extracellular Vesicle Protein Analysis Using Immuno- Droplet Digital Polymerase Chain Reaction Amplification
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New Technology on the Horizon: Fast Analytical Screening Technique FNA (FAST-FNA) Enables Rapid, Multiplex Biomarker Analysis in Head and Neck Cancers
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A durable murine model of spleen transplantation with arterial and venous anastomoses.
The chemical biology of IL-12 production via the non-canonical NFkB pathway
Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge.
Immunity. 2019;51(5):899-914.e7 - PMID: 31732166 - PMCID: PMC6892583 - DOI: 10.1016/j.immuni.2019.10.010
Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species.
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Crizotinib-induced immunogenic cell death in non-small cell lung cancer.
Glucocorticoids Regulate Bone Marrow B Lymphopoiesis After Stroke.
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Development of adamantane-conjugated TLR7/8 agonists for supramolecular delivery and cancer immunotherapy
Natural killer cells limit the clearance of senescent lung adenocarcinoma cells.
LTX-315 sequentially promotes lymphocyte-independent and lymphocyte-dependent antitumor effects.
Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12
Understanding the tumor immune microenvironment (TIME) for effective therapy.
Nature Med. 2018;24(5):541-550 - PMID: 29686425 - PMCID: PMC5998822 - DOI: 10.1038/s41591-018-0014-x
TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.
Nat Biomed Eng. 2018;2:578-588 - PMID: 31015631 - PMCID: PMC6192054 - DOI: 10.1038/s41551-018-0236-8
Quantitative Imaging of Tumor Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin.
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Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages
Age-related tumor growth in mice is related to integrin α 4 in CD8+ T cells
Recording the wild lives of immune cells.
Osteoblasts remotely supply lung tumors with cancer-promoting
SiglecFhigh neutrophils
Tumor Microenvironment: No Effector T Cells without Dendritic Cells.
Cancer Cell. 2017;31(5):614-615 - PMID: 28486102 - DOI: 10.1016/j.ccell.2017.04.007
Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging.
Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts
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In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy
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Intestinal epithelial cell-specific RARα depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system.
Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease
The role of myeloid cells in cancer therapies.
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SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions
Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy
Neutrophils suppress intraluminal NK-mediated tumor cell clearance and enhance extravasation of disseminated carcinoma cells.
Cancer Discov. 2016;6(6):630-49 - PMID: 27072748 - PMCID: PMC4918202 - DOI: 10.1158/2159-8290.CD-15-1157
Gal3 Links Inflammation and Insulin Resistance.
Cell Metab. 2016;24(5):655-656 - PMID: 27829136 - DOI: 10.1016/j.cmet.2016.10.014
Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway.
Proc Natl Acad Sci U S A. 2016;113(7):1871-6 - PMID: 26831087 - PMCID: PMC4763742 - DOI: 10.1073/pnas.1511380113
PF4 Promotes Platelet Production and Lung Cancer Growth.
Cell Rep. 2016;17(7):1764-1772 - PMID: 27829148 - PMCID: PMC5108525 - DOI: 10.1016/j.celrep.2016.10.031
ER Stress in Dendritic Cells Promotes Cancer.
Cell. 2015;161(7):1492-3 - PMID: 26091029 - DOI: 10.1016/j.cell.2015.06.006
Common TLR5 Mutations Control Cancer Progression.
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Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug.
Predicting therapeutic nano-medicine efficacy using a companion MR imaging nanoparticle.
Renal Intercalated Cells Sense and Mediate Inflammation via the P2Y14 Receptor.
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Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy.
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Imaging macrophages with nanoparticles.
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Harnessing the Intestinal Microbiome for Optimal Therapeutic Immunomodulation.
Cancer Res. 2014;74(16):4217-4221 - PMID: 25074615 - PMCID: PMC6700746 - DOI: 10.1158/0008-5472.CAN-14-0987
Gut microbiome and anticancer immune response: really hot Sh*t!
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Immune-dependent antineoplastic effects of cisplatin plus pyridoxine in non-small-cell lung cancer.
Oncogene. 2014;34(23):3053-62 - PMID: 25065595 - DOI: 10.1038/onc.2014.234
The journey from stem cell to macrophage.
Epithelial Basal Cells Are Distinct from Dendritic Cells and Macrophages in the Mouse Epididymis.
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Mononuclear phagocytes rapidly clear apoptotic epithelial cells in the proximal epididymis.
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The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide.
The spleen in local and systemic regulation of immunity.
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Angiotensin II Drives the Production of Tumor-Promoting Macrophages
Immunity. 2013;38(2):296-308 - PMID: 23333075 - PMCID: PMC3582771 - DOI: 10.1016/j.immuni.2012.10.015
Therapeutically reeducating macrophages to treat GBM.
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Molecular Pathways: Tumor-derived microvesicles and their interactions with immune cells in vivo.
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MicroRNA-mediated control of macrophages and its implications for cancer.
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Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer.
Remote control of macrophage production by cancer.
Myocardial infarction accelerates atherosclerosis
Innate Response Activator B Cells Protect Against Microbial Sepsis
PET/MRI of Inflammation in Myocardial Infarction
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Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis.
Origins of tumor-associated macrophages and neutrophils.
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Multi-Scale In Vivo Systems Analysis Reveals the Influence of Immune Cells on TNF-α-Induced Apoptosis in the Intestinal Epithelium
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Regulation of Monocyte Functional Heterogeneity by miR-146a and Relb
Regulation of Macrophage and Dendritic Cell Responses by Their Lineage Precursors.
Intravital imaging.
Therapeutic siRNA silencing in inflammatory monocytes in mice
In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation
Detection of Macrophages in Aortic Aneurysms by Nanoparticle Positron Emission Tomography-Computed Tomography.
Arterioscler Thromb Vasc Biol. 2011;31(4):750-7 - PMID: 21252070 - PMCID: PMC3060293 - DOI: 10.1161/ATVBAHA.110.221499
Dragon (Repulsive Guidance Molecule b) Inhibits IL-6 Expression in Macrophages.
Monocytes link atherosclerosis and cancer.
89Zr Labeled Dextran Nanoparticles Enable in vivo Macrophage Imaging.
A dense network of dendritic cells populates the murine epididymis.
Monocytes: protagonists of infarct inflammation and repair after myocardial infarction.
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Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis.
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Angiotensin-Converting Enzyme Inhibition Prevents the Release of Monocytes From Their Splenic Reservoir in Mice With Myocardial Infarction.
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Hybrid PET-optical imaging using targeted probes
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Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice.
Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomography.
Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites
Hybrid In Vivo FMT-CT Imaging of Protease Activity in Atherosclerosis With Customized Nanosensors.
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Heterogeneous In Vivo Behavior of Monocyte Subsets in Atherosclerosis.
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Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle
Behavior of immune players in the tumor microenvironment.
Curr Opin Oncol. 2009;21(1):53-9 - PMID: 19125019 - PMCID: PMC2901856 - DOI: 10.1097/CCO.0b013e32831bc38a
Monocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensors.
Imaging in the era of molecular oncology
Direct presentation of antigen by lymph node stromal cells protects against CD8 T-cell-mediated intestinal autoimmunity.
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Diversity of denizens of the atherosclerotic plaque: not all monocytes are created equal.
Circulation. 2008;117(25):3168-70 - PMID: 18574058 - DOI: 10.1161/CIRCULATIONAHA.108.783068
Perturbational profiling of nanomaterial biologic activity.
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Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation
Regulation of T-cell migration and effector functions: insights from in vivo imaging studies.
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Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct
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The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions.
In vivo imaging of T cell delivery to tumors after adoptive transfer therapy
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Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata
Regulation of T Cell Migration and Effector Functions-Insights from in Vivo Imaging Studies
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Four Functionally Distinct Populations of Human Effector-Memory CD8+ T Lymphocytes.
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A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses.
Improved in vivo whole-animal detection limits of green fluorescent protein-expressing tumor lines by spectral fluorescence imaging.
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Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
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Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease.
Proc Natl Acad Sci U S A. 2006;103(27):10340-5 - PMID: 16801531 - PMCID: PMC1502459 - DOI: 10.1073/pnas.0604260103
Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles
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Fluorescent Nanoparticle Uptake for Brain Tumor Visualization
Ex vivo characterization of allo-MHC-restricted T cells specific for a single MHC-peptide complex.
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Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-{beta} signals in vivo
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Optimum in vitro expansion of human antigen-specific CD8 T cells for adoptive transfer therapy.
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High frequency of functionally active Melan-a-specific T cells in a patient with progressive immunoproteasome-deficient melanoma.
Cancer Res. 2004;64:6319-26 - PMID: 15342421 - DOI: 10.1158/0008-5472.CAN-04-1341
Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional tolerance.
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Human thymus exports naive CD8 T cells that can home to nonlymphoid tissues.
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Ex vivo analysis of human antigen-specific CD8+ T-cell responses: quality assessment of fluorescent HLA-A2 multimer and interferon-gamma ELISPOT assays for patient immune monitoring.
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