Jenny Lu's Group
The central focus in Dr. Lu’s lab is to investigate clinically important questions using established, comprehensive, multidisciplinary approaches, and through diverse collaborations with experts in the field. We have a broad scope of research on kidney physiology and pathophysiology. We have developed multiple research projects and interests, including our current three main projects:
- Study integrin b1 trafficking in epithelial cells. We are investigating how the expression of integrin b1 and the integrin b1–ECM signaling contribute to the proper trafficking of membrane channels, including a water channel, AQP2; and we aim to understand the role of AQP2 in modulating the surface presentation and intracellular recycling of integrin b1.
- Study the trafficking and regulation of membrane transporters using AQP2 as a model. Through collaboration with Dr. Brown for many years, we have been studying the trafficking and regulation of AQP2 in response to vasopressin in vitro and in vivo. We hope to understand the general vesicular trafficking pathways through studying AQP2.
- We have developed a new line of interest in podocyte biology and glomerular pathophysiology in the past several years. Through a close collaboration with Dr. Alan Davidson, we have developed a podocyte specific ablation zebrafish model to study podocyte regeneration in zebrafish. We are also investigating mechanisms of vesicular trafficking in podocyte.