The central focus in Dr. Lu’s lab is to investigate clinically important questions using established, comprehensive, multidisciplinary approaches, and through diverse collaborations with experts in the field. We have a broad scope of research on kidney physiology and pathophysiology. We have developed multiple research projects and interests
Li W, Jin WW, Tsuji K, Chen Y, Nomura N, Su L, Yui N, Arthur J, Cotecchia S, Păunescu TG, Brown D, Lu HAJ Direct interaction of ezrin and AQP2 and its role in AQP2 trafficking. J Cell Sci. 2017;130(17):2914-2925 - PMID: 28754689 - PMCID: PMC5612225 - DOI: 10.1242/jcs.204842
Mamuya FA, Xie D, Lei L, Huang M, Tsuji K, Capen DE, Yang B, Weissleder R, Păunescu TG, Lu HJ Deletion of β-1 integrin in collecting duct principal cells leads to tubular injury and renal medullary fibrosis. Am J Physiol Renal Physiol. 2017;:ajprenal.00038.2017 - PMID: 28701310 - PMCID: PMC5668581 - DOI: 10.1152/ajprenal.00038.2017
Mamuya FA, Cano-Peñalver JL, Li WU, Rodriguez-Puyol D, Rodríguez-Puyol M, Brown D, de Frutos S, Lu HJ ILK and Cytoskeletal Architecture: An Important Determinant of AQP2 Recycling and Subsequent Entry into the Exocytotic Pathway. Am J Physiol Renal Physiol. 2016;:ajprenal.00336.2016 - PMID: 27760768 - PMCID: PMC5210194 - DOI: 10.1152/ajprenal.00336.2016
Cheung PW, Nomura N, Nair AV, Pathomthongtaweechai N, Ueberdiek L, Lu HA, Brown D, Bouley R EGF Receptor Inhibition by Erlotinib Increases Aquaporin 2-Mediated Renal Water Reabsorption. J Am Soc Nephrol. 2016;27(10):3105-3116 - PMID: 27694161 - PMCID: PMC5042667 - DOI: 10.1681/ASN.2015080903
Arthur J, Huang J, Nomura N, Jin WW, Li W, Cheng X, Brown D, Lu HJ Characterization of the putative phosphorylation sites of the AQP2 c-terminus and their role in AQP2 trafficking in LLC-PK1 cells. Am J Physiol Renal Physiol. 2015;:ajprenal.00152.2015 - PMID: 26290367 - PMCID: PMC4609919 - DOI: 10.1152/ajprenal.00152.2015
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Study integrin b1 trafficking in epithelial cells. We are investigating how the expression of integrin b1 and the integrin b1–ECM signaling contribute to the proper trafficking of membrane channels, including a water channel, AQP2; and we aim to understand the role of AQP2 in modulating the surface presentation and intracellular recycling of integrin b1.
Study the trafficking and regulation of membrane transporters using AQP2 as a model. Through collaboration with Dr. Brown for many years, we have been studying the trafficking and regulation of AQP2 in response to vasopressin in vitro and in vivo. We hope to understand the general vesicular trafficking pathways through studying AQP2..
We have developed a new line of interest in podocyte biology and glomerular pathophysiology in the past several years. Through a close collaboration with Dr. Alan Davidson, we have developed a podocyte specific ablation zebrafish model to study podocyte regeneration in zebrafish. We are also investigating mechanisms of vesicular trafficking in podocyte.