Lee, Hakho, PhD

Professor

Biomedical Engineering

Phone: 617-726-6487
Email: hlee@mgh.harvard.edu
Lab: Lee, Hakho

Hakho Lee, Ph.D., is a Professor of Radiology at Harvard Medical School. He is also the Director of the Biomedical Engineering Program at the Center for Systems Biology (CSB) at Massachusetts General Hospital (MGH). He is a Hostetter MGH Research Scholar, a core faculty at the MGH Institute for Innovation in Imaging (i3), and a global faculty at the IBS Center for NanoMedicine in Korea. Dr. Lee earned his Ph.D. in Physics from Harvard University and conducted his postdoctoral training at MGH. He has expertise in nanomaterials, biophysics, and electrical engineering, and he focuses his research on creating novel biomedical sensors for clinical applications. He is currently leading the Biomedical Engineering Program at CSB.

Publications

  • Landeros C, Oh J, Weissleder R, Lee H Deep learning pipeline for automated cell profiling from cyclic imaging. Sci Rep. 2024;14(1):23600 - PMID: 39384907 - PMCID: PMC11464789 - DOI: 10.1038/s41598-024-74597-w

  • Lee S, Lee J, Kim H, Lee H, Park HG Novel lateral flow assay to detect H2O2 by utilizing self-biotinylation of G-quadruplex. Biosens Bioelectron. 2024;267:116811 - PMID: 39378787 - DOI: 10.1016/j.bios.2024.116811

  • Song J, Cho MH, Cho H, Song Y, Lee SW, Nam HC, Yoon TH, Shin JC, Hong JS, Kim Y, Ekanayake E, Jeon J, You DG, Im SG, Choi GS, Park JS, Carter BC, Balaj L, Seo AN, Miller MA, Park SY, Kang T, Castro CM, Lee H Amplifying mutational profiling of extracellular vesicle mRNA with SCOPE. Nat Biotechnol. 2024;:ePub - PMID: 39375445 - DOI: 10.1038/s41587-024-02426-6

  • Kim JJ, Hong JS, Kim H, Choi M, Winter U, Lee H, Im H CRISPR/Cas13a-assisted amplification-free miRNA biosensor via dark-field imaging and magnetic gold nanoparticles. Sens Diagn. 2024;3(8):1310-1318 - PMID: 39129860 - PMCID: PMC11308380 - DOI: 10.1039/d4sd00081a

  • Lee CY, Kim H, Degani I, Lee H, Sandoval A, Nam Y, Pascavis M, Park HG, Randall T, Ly A, Castro CM, Lee H Empowering the on-site detection of nucleic acids by integrating CRISPR and digital signal processing. Nat Commun. 2024;15(1):6271 - PMID: 39054353 - PMCID: PMC11272939 - DOI: 10.1038/s41467-024-50588-3

  • Bae JH, Lee CH, Jung D, Yea K, Song BJ, Lee H, Baek MC Extracellular vesicle isolation and counting system (EVics) based on simultaneous tandem tangential flow filtration and large field-of-view light scattering. J Extracell Vesicles. 2024;13(7):e12479 - PMID: 38978321 - PMCID: PMC11231039 - DOI: 10.1002/jev2.12479

  • You DG, Jung JM, Kim CH, An JY, Bui VD, Lee J, Um W, Jo DG, Cho YW, Lee DS, Balaj L, Lee H, Park JH Stem Cell-Derived Extracellular Vesicle-Bearing Injectable Hydrogel for Collagen Generation in Dermis. ACS Appl Mater Interfaces. 2024;16(29):37698-37706 - PMID: 38980897 - DOI: 10.1021/acsami.4c07434

  • Arai MS, Kim H, Pascavis M, Cha B, Brambilla G, Cho YK, Park J, Vilela RRC, de Camargo ASS, Castro CM, Lee H Upconverting Nanoparticle-based Enhanced Luminescence Lateral-Flow Assay for Urinary Biomarker Monitoring. ACS Appl Mater Interfaces. 2024;16(29):38243-38251 - PMID: 38980927 - DOI: 10.1021/acsami.4c06117

  • Ssedyabane F, Obuku EA, Namisango E, Ngonzi J, Castro CM, Lee H, Randall TC, Ocan M, Apunyo R, Annet Kinengyere A, Kajabwangu R, Tahirah Kisawe A, Nambi Najjuma J, Tusubira D, Niyonzima N The diagnostic accuracy of serum and plasma microRNAs in detection of cervical intraepithelial neoplasia and cervical cancer: A systematic review and meta-analysis. Gynecol Oncol Rep. 2024;54:101424 - PMID: 38939506 - PMCID: PMC11208915 - DOI: 10.1016/j.gore.2024.101424

  • Ssedyabane F, Niyonzima N, Nambi Najjuma J, Birungi A, Atwine R, Tusubira D, Randall TC, Castro CM, Lee H, Ngonzi J Prevalence of cervical intraepithelial lesions and associated factors among women attending a cervical cancer clinic in Western Uganda; results based on Pap smear cytology. SAGE Open Med. 2024;12:20503121241252265 - PMID: 38764539 - PMCID: PMC11100407 - DOI: 10.1177/20503121241252265

  • Stollmann A, Garcia-Guirado J, Hong JS, Rüedi P, Im H, Lee H, Ortega Arroyo J, Quidant R Molecular fingerprinting of biological nanoparticles with a label-free optofluidic platform. Nat Commun. 2024;15(1):4109 - PMID: 38750038 - PMCID: PMC11096335 - DOI: 10.1038/s41467-024-48132-4

  • Barth I, Lee H Phase-driven progress in nanophotonic biosensing. Light Sci Appl. 2024;13(1):76 - PMID: 38494520 - PMCID: PMC10944832 - DOI: 10.1038/s41377-024-01415-3

  • Welsh, JA Goberdhan, DCI O'Driscoll, L Buzas, EI Blenkiron, C Bussolati, B Cai, H Di Vizio, D Driedonks, TAP Erdbrügger, U Falcon-Perez, JM Fu, QL Hill, AF Lenassi, M Lim, SK Mahoney, MG Mohanty, S Möller, A Nieuwland, R Ochiya, T Sahoo, S Torrecilhas, AC Zheng, L Zijlstra, A Abuelreich, S Bagabas, R Bergese, P Bridges, EM Brucale, M Burger, D Carney, RP Cocucci, E Crescitelli, R Hanser, E Harris, AL Haughey, NJ Hendrix, A Ivanov, AR Jovanovic-Talisman, T Kruh-Garcia, NA Ku'ulei-Lyn Faustino, V Kyburz, D Lässer, C Lennon, KM Lötvall, J Maddox, AL Martens-Uzunova, ES Mizenko, RR Newman, LA Ridolfi, A Rohde, E Rojalin, T Rowland, A Saftics, A Sandau, US Saugstad, JA Shekari, F Swift, S Ter-Ovanesyan, D Tosar, JP Useckaite, Z Valle, F Varga, Z van der Pol, E van Herwijnen, MJC Wauben, MHM Wehman, AM Williams, S Zendrini, A Zimmerman, AJ MISEV, Consortium Théry, C Witwer, KW Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. J Extracell Vesicles. 2024;2:e12404 - PMID: 38326288 - PMCID: PMC10850029 - DOI: 10.1002/jev2.12404

  • Landeros C, Oh J, Weissleder R, Lee H Deep Learning Pipeline for Automated Cell Profiling from Cyclic Imaging. Res Sq. 2023;:ePub - PMID: 38196620 - PMCID: PMC10775369 - DOI: 10.21203/rs.3.rs-3745061/v1

  • Araki M, Park SJ, Dauerman HL, Uemura S, Kim JS, Di Mario C, Johnson TW, Guagliumi G, Kastrati A, Joner M, Holm NR, Alfonso F, Wijns W, Adriaenssens T, Nef H, Rioufol G, Amabile N, Souteyrand G, Meneveau N, Gerbaud E, Opolski MP, Gonzalo N, Tearney GJ, Bouma B, Aguirre AD, Mintz GS, Stone GW, Bourantas CV, Räber L, Gili S, Mizuno K, Kimura S, Shinke T, Hong MK, Jang Y, Cho JM, Yan BP, Porto I, Niccoli G, Montone RA, Thondapu V, Papafaklis MI, Michalis LK, Reynolds H, Saw J, Libby P, Weisz G, Iannaccone M, Gori T, Toutouzas K, Yonetsu T, Minami Y, Takano M, Raffel OC, Kurihara O, Soeda T, Sugiyama T, Kim HO, Lee T, Higuma T, Nakajima A, Yamamoto E, Bryniarski KL, Di Vito L, Vergallo R, Fracassi F, Russo M, Seegers LM, McNulty I, Park S, Feldman M, Escaned J, Prati F, Arbustini E, Pinto FJ, Waksman R, Garcia-Garcia HM, Maehara A, Ali Z, Finn AV, Virmani R, Kini AS, Daemen J, Kume T, Hibi K, Tanaka A, Akasaka T, Kubo T, Yasuda S, Croce K, Granada JF, Lerman A, Prasad A, Regar E, Saito Y, Sankardas MA, Subban V, Weissman NJ, Chen Y, Yu B, Nicholls SJ, Barlis P, West NEJ, Arbab-Zadeh A, Ye JC, Dijkstra J, Lee H, Narula J, Crea F, Nakamura S, Kakuta T, Fujimoto J, Fuster V, Jang IK Author Correction: Optical coherence tomography in coronary atherosclerosis assessment and intervention. Nat Rev Cardiol. 2023;21(5):348 - PMID: 38110566 - DOI: 10.1038/s41569-023-00982-z

  • Arroyo JO, Stollmann A, Garcia-Guirado J, Hong JS, Im H, Lee H, Quidant R Molecular fingerprinting of biological nanoparticles with a label-free optofluidic platform. Res Sq. 2023;:ePub - PMID: 37886549 - PMCID: PMC10602063 - DOI: 10.21203/rs.3.rs-3309306/v1

  • Yekula A, Hsia T, Kitchen RR, Chakrabortty SK, Yu W, Batool SM, Lewis B, Szeglowski AJ, Weissleder R, Lee H, Chi AS, Batchelor T, Carter BS, Breakefield XO, Skog J, Balaj L Longitudinal analysis of serum-derived extracellular vesicle RNA to monitor dacomitinib treatment response in EGFR-amplified recurrent glioblastoma patients. Neurooncol Adv. 2023;5(1):vdad104 - PMID: 37811539 - PMCID: PMC10559837 - DOI: 10.1093/noajnl/vdad104

  • Batool SM, Hsia T, Beecroft A, Lewis B, Ekanayake E, Rosenfeld Y, Escobedo AK, Gamblin AS, Rawal S, Cote RJ, Watson M, Wong DTW, Patel AA, Skog J, Papadopoulos N, Bettegowda C, Castro CM, Lee H, Srivastava S, Carter BS, Balaj L Extrinsic and intrinsic preanalytical variables affecting liquid biopsy in cancer. Cell Rep Med. 2023;4(10):101196 - PMID: 37725979 - PMCID: PMC10591035 - DOI: 10.1016/j.xcrm.2023.101196

  • Batool SM, Yekula A, Khanna P, Hsia T, Gamblin AS, Ekanayake E, Escobedo AK, You DG, Castro CM, Im H, Kilic T, Garlin MA, Skog J, Dinulescu DM, Dudley J, Agrawal N, Cheng J, Abtin F, Aberle DR, Chia D, Elashoff D, Grognan T, Krysan K, Oh SS, Strom C, Tu M, Wei F, Xian RR, Skates SJ, Zhang DY, Trinh T, Watson M, Aft R, Rawal S, Agarwal A, Kesmodel SB, Yang C, Shen C, Hochberg FH, Wong DTW, Patel AA, Papadopoulos N, Bettegowda C, Cote RJ, Srivastava S, Lee H, Carter BS, Balaj L The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring. Cell Rep Med. 2023;4(10):101198 - PMID: 37716353 - PMCID: PMC10591039 - DOI: 10.1016/j.xcrm.2023.101198

  • Yekula A, Hsia T, Kitchen RR, Chakrabortty SK, Yu W, Batool MS, Lewis B, Szeglowski AJ, Weissleder R, Lee H, Chi AS, Batchelor T, Carter BS, Breakefield XO, Skog J, Balaj L Longitudinal analysis of serum-derived extracellular vesicle RNA to monitor dacomitinib treatment response in EGFR amplified recurrent glioblastoma patients. Neurooncol Adv. 2023;:ePub - DOI: 10.1093/noajnl/vdad104

  • Hsia T, You DG, Politis MG, Batool SM, Ekanayake E, Lee H, Carter BS, Balaj L Rigorous Comparison of Extracellular Vesicle Processing to Enhance Downstream Analysis for Glioblastoma Characterization. Adv Biol (Weinh). 2023;8(1):e2300233 - PMID: 37670402 - DOI: 10.1002/adbi.202300233

  • Stollmann A, Garcia-Guirado J, Hong JS, Im H, Lee H, Arroyo JO, Quidant R Molecular fingerprinting of biological nanoparticles with a label-free optofluidic platform. arXiv. 2023;:ePub - PMID: 37608933 - PMCID: PMC10441434

  • Hsia T, Small JL, Yekula A, Batool SM, Escobedo AK, Ekanayake E, You DG, Lee H, Carter BS, Balaj L Systematic Review of Photodynamic Therapy in Gliomas. Cancers (Basel). 2023;15(15):ePub - PMID: 37568734 - PMCID: PMC10417382 - DOI: 10.3390/cancers15153918

  • Jo A, Green A, Medina JE, Iyer S, Ohman AW, McCarthy ET, Reinhardt F, Gerton T, Demehin D, Mishra R, Kolin DL, Zheng H, Cheon J, Crum CP, Weinberg RA, Rueda BR, Castro CM, Dinulescu DM, Lee H Inaugurating High-Throughput Profiling of Extracellular Vesicles for Earlier Ovarian Cancer Detection. Adv Sci (Weinh). 2023;10(27):e2301930 - PMID: 37485618 - PMCID: PMC10520636 - DOI: 10.1002/advs.202301930

  • Kwak TJ, Son T, Hong JS, Winter UA, Jeong MH, McLean C, Weissleder R, Lee H, Castro CM, Im H Electrokinetically enhanced label-free plasmonic sensing for rapid detection of tumor-derived extracellular vesicles. Biosens Bioelectron. 2023;237:115422 - PMID: 37301179 - PMCID: PMC10527155 - DOI: 10.1016/j.bios.2023.115422

  • Song TH, Cao M, Min J, Im H, Lee H, Lee K Deep learning-based phenotyping of breast cancer cells using lens-free digital in-line holography. Biophys J. 2023;122(3S1):285a - PMID: 36783413 - DOI: 10.1016/j.bpj.2022.11.1619

  • Roh YH, Lee CY, Lee S, Kim H, Ly A, Castro CM, Cheon J, Lee JH, Lee H CRISPR-Enhanced Hydrogel Microparticles for Multiplexed Detection of Nucleic Acids. Adv Sci (Weinh). 2023;10(10):e2206872 - PMID: 36725305 - PMCID: PMC10074104 - DOI: 10.1002/advs.202206872

  • Jo A, Green A, Medina JE, Iyer S, Ohman AW, McCarthy ET, Reinhardt F, Gerton T, Demehin D, Mishra R, Kolin DL, Zheng H, Crum CP, Weinberg RA, Rueda BR, Castro CM, Dinulescu DM, Lee H Profiling extracellular vesicles in circulation enables the early detection of ovarian cancer. bioRxiv. 2023;:ePub - PMID: 36711872 - PMCID: PMC9882285 - DOI: 10.1101/2023.01.19.524549

  • Hsia T, Yekula A, Batool SM, Rosenfeld YB, You DG, Weissleder R, Lee H, Carter BS, Balaj L Glioblastoma-derived extracellular vesicle subpopulations following 5-aminolevulinic acid treatment bear diagnostic implications. J Extracell Vesicles. 2022;11(11):e12278 - PMID: 36404434 - PMCID: PMC9676504 - DOI: 10.1002/jev2.12278

  • Cho YK, Kim H, Bénard A, Woo HK, Czubayko F, David P, Hansen FJ, Lee JI, Park JH, Schneck E, Weber GF, Shin IK, Lee H Electrochemiluminescence in paired signal electrode (ECLipse) enables modular and scalable biosensing. Sci Adv. 2022;8:eabq4022 - PMID: 36129990 - PMCID: PMC9491722 - DOI: 10.1126/sciadv.abq4022

  • Kim H, Sa JK, Kim J, Cho HJ, Oh HJ, Choi DH, Kang SH, Jeong DE, Nam DH, Lee H, Lee HW, Chung S Recapitulated Crosstalk between Cerebral Metastatic Lung Cancer Cells and Brain Perivascular Tumor Microenvironment in a Microfluidic Co-Culture Chip. Adv Sci (Weinh). 2022;9(22):e2201785 - PMID: 35657027 - PMCID: PMC9353479 - DOI: 10.1002/advs.202201785

  • Park JH, Park EK, Cho YK, Shin IS, Lee H Normalizing the Optical Signal Enables Robust Assays with Lateral Flow Biosensors. ACS Omega. 2022;7(21):17723-17731 - PMID: 35664567 - PMCID: PMC9161384 - DOI: 10.1021/acsomega.2c00793

  • Peterson HM, Chin LK, Iwamoto Y, Oh J, Carlson JCT, Lee H, Im H, Weissleder R Integrated Analytical System for Clinical Single-Cell Analysis. Adv Sci (Weinh). 2022;9(20):e2200415 - PMID: 35508767 - PMCID: PMC9284190 - DOI: 10.1002/advs.202200415

  • Woo HK, Cho YK, Lee CY, Lee H, Castro CM, Lee H Characterization and modulation of surface charges to enhance extracellular vesicle isolation in plasma. Theranostics. 2022;12(5):1988-1998 - PMID: 35265194 - PMCID: PMC8899565 - DOI: 10.7150/thno.69094 - Cover

  • Kilic T, Cho YK, Jeong N, Shin IS, Carter BS, Balaj L, Weissleder R, Lee H Multielectrode Spectroscopy Enables Rapid and Sensitive Molecular Profiling of Extracellular Vesicles. ACS Cent Sci. 2022;8(1):110-117 - PMID: 35111901 - PMCID: PMC8802188 - DOI: 10.1021/acscentsci.1c01193

  • Cheon J, Qin J, Lee LP, Lee H Advances in Biosensor Technologies for Infection Diagnostics. Acc Chem Res. 2022;55(2):121-122 - PMID: 35038867 - DOI: 10.1021/acs.accounts.1c00647

  • Min J, Allen M, Castro CM, Lee H, Weissleder R, Im H Computational Optics for Point-of-Care Breast Cancer Profiling. Methods Mol Biol. 2022;2393:153-162 - PMID: 34837178 - PMCID: PMC9283060 - DOI: 10.1007/978-1-0716-1803-5_8

  • Gessner I, Park JH, Lin HY, Lee H, Weissleder R Magnetic Gold Nanoparticles with Idealized Coating for Enhanced Point-Of-Care Sensing. Adv Healthc Mater. 2021;11(2):e2102035 - PMID: 34747576 - PMCID: PMC8770610 - DOI: 10.1002/adhm.202102035

  • Kilic T, Gessner I, Cho Y, Jeong N, Quintana J, Weissleder R, Lee H Zwitterionic polymer electroplating facilitates the preparation of electrode surface for biosensing. Adv Mater. 2021;34(8):e2107892 - PMID: 34890082 - PMCID: PMC8881349 - DOI: 10.1002/adma.202107892

  • Lee CY, Degani I, Cheong J, Weissleder R, Lee JH, Cheon J, Lee H Development of Integrated Systems for On-Site Infection Detection. Acc Chem Res. 2021;54(21):3991-4000 - PMID: 34677927 - PMCID: PMC9099220 - DOI: 10.1021/acs.accounts.1c00498

  • Yu H, Lee H, Cheong J, Woo SW, Oh J, Oh HK, Lee JH, Zheng H, Castro CM, Yoo YE, Kim MG, Cheon J, Weissleder R, Lee H A rapid assay provides on-site quantification of tetrahydrocannabinol in oral fluid. Sci Transl Med. 2021;13(616):eabe2352 - PMID: 34669441 - PMCID: PMC9126021 - DOI: 10.1126/scitranslmed.abe2352 - Cover

  • Oh J, Carlson JCT, Landeros C, Lee H, Ferguson S, Faquin WC, Clark JR, Pittet MJ, Pai SI, Weissleder R Rapid serial immunoprofiling of the tumor immune microenvironment by fine needle sampling. Clin Cancer Res. 2021;27(17):4781-4793 - PMID: 34233961 - PMCID: PMC8416923 - DOI: 10.1158/1078-0432.CCR-21-1252

  • Park J, Park JS, Huang CH, Jo A, Cook K, Wang R, Lin HY, Van Deun J, Li H, Min J, Wang L, Yoon G, Carter BS, Balaj L, Choi GS, Castro CM, Weissleder R, Lee H An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma. Nat Biomed Eng. 2021;5(7):678-689 - PMID: 34183802 - PMCID: PMC8437135 - DOI: 10.1038/s41551-021-00752-7

  • Wang Z, Shin J, Park JH, Lee H, Kim DH, Liu H Engineering Materials for Electrochemical Sweat Sensing. Adv Funct Mater. 2021;:ePub - DOI: 10.1002/adfm.202008130

  • Lee CY, Degani I, Cheong J, Lee JH, Choi HJ, Cheon J, Lee H Fluorescence polarization system for rapid COVID-19 diagnosis. Biosens Bioelectron. 2021;178:113049 - PMID: 33540323 - PMCID: PMC7846465 - DOI: 10.1016/j.bios.2021.113049

  • Ortiz-Orruño U, Jo A, Lee H, van Hulst NF, Liebel M Precise Nanosizing with High Dynamic Range Holography. Nano Lett. 2020;21(1):317-322 - PMID: 33346670 - PMCID: PMC8326875 - DOI: 10.1021/acs.nanolett.0c03699

  • Kim H, Choia SK, Ahn J, Yu H, Kyoungha Min K, Hong C, Shin IS, Lee S, Lee H, Im H, Ko JG, Kim E Kaleidoscopic fluorescent arrays for machine-learning-based point-of-care chemical sensing. Sensors and Actuators B: Chemical. 2020;329:129248 - DOI: 10.1016/j.snb.2020.129248

  • Cheong J, Yu H, Lee CY, Lee JU, Choi HJ, Lee JH, Lee H, Cheon J Fast detection of SARS-CoV-2 RNA via the integration of plasmonic thermocycling and fluorescence detection in a portable device. Nat Biomed Eng. 2020;4(12):1159-1167 - PMID: 33273713 - PMCID: PMC8202505 - DOI: 10.1038/s41551-020-00654-0

  • Liebel M, Ortega Arroyo J, Beltrán VS, Osmond J, Jo A, Lee H, Quidant R, van Hulst NF 3D tracking of extracellular vesicles by holographic fluorescence imaging. Sci Adv. 2020;6(45):ePub - PMID: 33148645 - PMCID: PMC7673696 - DOI: 10.1126/sciadv.abc2508

  • Chin LK*, Son T*, Hong JS, Liu AQ, Skog J, Castro CM, Weissleder R, Lee H*, Im H* Plasmonic Sensors for Extracellular Vesicle Analysis: From Scientific Development to Translational Research. ACS Nano. 2020;14(11):14528-14548 - PMID: 33119256 - PMCID: PMC8423498 - DOI: 10.1021/acsnano.0c07581

  • Yang KS, Lin HY, Curley C, Welch MW, Wolpin BM, Lee H, Weissleder R, Im H*, Castro CM* Bead-Based Extracellular Vesicle Analysis Using Flow Cytometry. Adv Biosyst. 2020;4(12):e2000203 - PMID: 33103361 - PMCID: PMC7718389 - DOI: 10.1002/adbi.202000203

  • Muralidharan K, Yekula A, Small JL, Rosh ZS, Kang KM, Wang L, Lau S, Zheng H, Lee H, Bettegowda C, Chicoine MR, Kalkanis S, Shankar GM, Nahed BV, Curry WT, Jones PS, Cahill DP, Balaj L, Carter BS TERT promoter mutation analysis for blood-based diagnosis and monitoring of gliomas. Clin Cancer Res. 2020;27(1):169-178 - PMID: 33051308 - PMCID: PMC7785705 - DOI: 10.1158/1078-0432.CCR-20-3083

  • Chand S, Jo A, Vellichirammal NN, Gowen A, Guda C, Schaal V, Odegaard K, Lee H, Pendyala G, Yelamanchili AV Comprehensive Characterization of Nanosized Extracellular Vesicles from Central and Peripheral Organs: Implications for Preclinical and Clinical Applications. ACS Appl Mater Interfaces. 2020;9:8906–8919 - DOI: 10.1021/acsanm.0c01654

  • Min J, Son T, Hong JS, Cheah PS Wegemann A, Murlidharan K, Weissleder R, Lee H, Im H Plasmon-Enhanced Biosensing for Multiplexed Profiling of Extracellular Vesicles. Adv Biosyst. 2020;2020:2000003 - PMID: 32815321 - PMCID: PMC7718316 - DOI: 10.1002/adbi.202000003 - Cover

  • Min J*, Chin LK*, Oh J, Landeros C, Vinegoni C, Lee J, Lee SJ, Park JY, Liu AQ, Castro CM, Lee H, Im H, Weissleder R CytoPAN—Portable cellular analyses for rapid point-of-care cancer diagnosis. Sci Transl Med. 2020;12:eaaz9746 - PMID: 32759277 - PMCID: PMC8217912 - DOI: 10.1126/scitranslmed.aaz9746

  • Kilic T, Weissleder R, Lee H Molecular and immunological diagnostic tests of COVID-19 – current status and challenges. iScience. 2020;23(8):101406 - PMID: 32771976 - PMCID: PMC7381402 - DOI: 10.1016/j.isci.2020.101406

  • Weissleder R, Lee H, Ko J, Pittet MJ COVID-19 diagnostics in context. Sci Transl Med. 2020;12(546):eabc1931 - PMID: 32493791 - DOI: 10.1126/scitranslmed.abc1931

  • Van Deun J, Jo A, Li H, Lin HY, Weissleder R, Im H, Lee H Integrated Dual-Mode Chromatography to Enrich Extracellular Vesicles from Plasma. Adv Biosyst. 2020;4(12):e1900310 - PMID: 32351054 - PMCID: PMC7606548 - DOI: 10.1002/adbi.201900310

  • Weissleder R, Lee H Automated molecular-image cytometry and analysis in modern oncology. Nature Review Materials. 2020;:ePub - DOI: 10.1038/s41578-020-0180-6

  • Raisbeck JC, Allen M, Weissleder R, Im H, Lee H Evolution Strategies Converges to Finite Differences. arXiv. 2020;:ePub

  • Yekula A, Minciacchi VR, Morello M, Shao H, Park Y, Zhang X, Muralidharan K, Freeman MR, Weissleder R, Lee H, Carter B, Breakefield XO, Di Vizio D, Balaj L Large and small extracellular vesicles released by glioma cells in vitro and in vivo. J Extracell Vesicles. 2019;9(1):1689784 - PMID: 31839905 - PMCID: PMC6896449 - DOI: 10.1080/20013078.2019.1689784

  • Zaborowski MP, Cheah PS, Zhang X, Bushko I, Lee K, Sammarco A, Zappulli V, Maas SLN, Allen RM, Rumde P, György B, Aufiero M, Schweiger MW, Lai CP, Weissleder R, Lee H, Vickers KC, Tannous BA, Breakefield XO Membrane-bound Gaussia luciferase as a tool to track shedding of membrane proteins from the surface of extracellular vesicles. Sci Rep. 2019;9(1):17387 - PMID: 31758005 - PMCID: PMC6874653 - DOI: 10.1038/s41598-019-53554-y

  • Pathania D, Landeros C, Rohrer L, D’Agostino V, Hong S, Degani I, Avila-Wallace M, Pivovarov M, Randall T, Weissleder R, Lee H, Im H, Castro CM Point-of-care cervical cancer screening using deep learning-based microholography. Theranostics. 2019;9(26):8438-8447 - PMID: 31879529 - PMCID: PMC6924258 - DOI: 10.7150/thno.37187

  • Huang CH, Park YI, Lin HY, Pathania D, Park KS, Avila-Wallace M, Castro CM, Weissleder R, Lee H Compact and Filter-Free Luminescence Biosensor for Mobile In-Vitro Diagnoses. ACS Nano. 2019;13(10):11698-11706 - PMID: 31461265 - PMCID: PMC7307311 - DOI: 10.1021/acsnano.9b05634

  • Gyuris A, Navarrete-Perea J, Jo A, Cristea S, Zhou S, Fraser K, Wei Z, Krichevsky AM, Weissleder R, Lee H, Gygi SP, Charest A Physical and Molecular Landscapes of Mouse Glioma Extracellular Vesicles Define Heterogeneity. Cell Rep. 2019;27(13):3972-3987.e6 - PMID: 31242427 - PMCID: PMC6604862 - DOI: 10.1016/j.celrep.2019.05.089

  • Lee H, Castro CM Thermophoretically enriched detection. Nat Biomed Eng. 2019;3(3):163-164 - PMID: 30948812 - DOI: 10.1038/s41551-019-0364-9

  • Zaborowski MP, Lee K, Na YJ, Sammarco A, Zhang X, Iwanicki M, Cheah PS, Lin HY, Zinter M, Chou CY, Fulci G, Tannous BA, Lai CP, Birrer MJ, Weissleder R, Lee H, Breakefield XO Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles. Cell Rep. 2019;27(1):255-268.e6 - PMID: 30943406 - PMCID: PMC6528836 - DOI: 10.1016/j.celrep.2019.03.003

  • Bae SH, Jo A, Park JH, Lim CW, Choi Y, Oh J, Park JM, Kong T, Weissleder R, Lee H, Moon J Bioassay for monitoring the anti-aging effect of cord blood treatment. Theranostics. 2019;9(1):1-10 - PMID: 30662549 - PMCID: PMC6332798 - DOI: 10.7150/thno.30422

  • Fraser K, Jo A, Giedt J, Vinegoni C, Yang KS, Peruzzi P, Chiocca EA, Breakefield XO, Lee H, Weissleder R Characterization of single microvesicles in plasma from glioblastoma patients. Neuro Oncol. 2019;21(5):606-615 - PMID: 30561734 - PMCID: PMC6502493 - DOI: 10.1093/neuonc/noy187

  • Kim SJ*, Wang C*, Zhao B, Im H, Min J, Choi HJ, Tadros J, Choi NR, Castro CM, Weissleder R, Lee H, Lee K Deep transfer learning-based hologram classification for molecular diagnostics. Sci Rep. 2018;8(1):17003 - PMID: 30451953 - PMCID: PMC6242900 - DOI: 10.1038/s41598-018-35274-x

  • Min J, Im H, Allen M, McFarland PJ, Degani I, Yu H, Normandin E, Pathania D, Patel J, Castro CM, Weissleder R, Lee H Computational Optics Enables Breast Cancer Profiling in Point-Of-Care Settings. ACS Nano. 2018;12(9):9081-9090 - PMID: 30113824 - PMCID: PMC6519708 - DOI: 10.1021/acsnano.8b03029

  • Im H, Pathania D, McFarland PJ, Sohani AR, Degani I, Allen M, Coble M, Kilcoyne A, Hong S, Rohrer L, Abramson JS, Dryden-Peterson S, Fexon L, Pivovarov M, Chabner B, Lee H, Castro CM, Weissleder R Design and clinical validation of a point-of-care device for the diagnosis of lymphoma via contrast- enhanced microholography and machine learning. Nat Biomed Eng. 2018;2(9):666-674 - PMID: 30555750 - PMCID: PMC6291220 - DOI: 10.1038/s41551-018-0265-3

  • Ling R, Tahir W, Lin HY, Lee H, Tian L High-throughput intensity diffraction tomography with a computational microscope. Biomed Opt Express. 2018;9(5):2130-2141 - PMID: 29760975 - PMCID: PMC5946776 - DOI: 10.1364/BOE.9.002130

  • Li K, Rodosthenous RS, Kashanchi F, Gingeras T, Gould SJ, Kuo LS, Kurre P, Lee H, Leonard JN, Liu H, Lombo TB, Momma S, Nolan JP, Ochocinska MJ, Pegtel DM, Sadovsky Y, Sánchez-Madrid F, Valdes KM, Vickers KC, Weaver AM, Witwer KW, Zeng Y, Das S, Raffai RL, Howcroft TK Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop. JCI Insight. 2018;3(7):ePub - PMID: 29618663 - PMCID: PMC5928855 - DOI: 10.1172/jci.insight.98942

  • Loyer X, Zlatanova I, Devue C, Yin M, Howangyin KY, Klaihmon P, Guerin CL, Kheloufi M, Vilar J, Zannis K, Fleischmann BK, Hwang DW, Park J, Lee H, Menasche P, Silvestre JS, Boulanger CM Intra-Cardiac Release of Extracellular Vesicles Shapes Inflammation Following Myocardial Infarction. Circ Res. 2018;123(1):100-106 - PMID: 29592957 - PMCID: PMC6023578 - DOI: 10.1161/CIRCRESAHA.117.311326

  • Ricklefs FL, Alayo Q, Krenzlin H, Mahmoud AB, Speranza MC, Nakashima H, Hayes JL, Lee K, Balaj L, Passaro C, Rooj AK, Krasemann S, Carter BS, Chen CC, Steed T, Treiber J, Rodig S, Yang K, Nakano I, Lee H, Weissleder R, Breakefield XO, Godlewski J, Westphal M, Lamszus K, Freeman GJ, Bronisz A, Lawler SE, Chiocca EA Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles. Sci Adv. 2018;4(3):eaar2766 - PMID: 29532035 - PMCID: PMC5842038 - DOI: 10.1126/sciadv.aar2766

  • Min J, Nothing M, Coble B, Zheng H, Park J, Im H, Weber GF, Castro CM, Swirski FK, Weissleder R, Lee H Integrated Biosensor for Rapid and Point-Of-Care Sepsis Diagnosis. ACS Nano. 2018;12(4):3378-3384 - PMID: 29533646 - PMCID: PMC6019292 - DOI: 10.1021/acsnano.7b08965

  • Lin HY, Yang KS, Curley C, Lee H, Welch MW, Wolpin BM, Weissleder R, Im H, Castro C Bead Enhancement of EV Analysis. bioRxiv. 2018;:ePub - DOI: 10.1101/269423

  • Shao H, Im H, Castro CM, Breakefield X, Weissleder R, Lee H New Technologies for Analysis of Extracellular Vesicles. Chem Rev. 2018;118(4):1917-1950 - PMID: 29384376 - PMCID: PMC6029891 - DOI: 10.1021/acs.chemrev.7b00534

  • Lee K, Fraser K, Ghaddar B, Yang K, Kim E, Balaj L, Chiocca A, Breakefield XO, Lee H, Weissleder R Multiplexed Profiling of Single Extracellular Vesicles. ACS Nano. 2018;12(1):494-503 - PMID: 29286635 - PMCID: PMC5898240 - DOI: 10.1021/acsnano.7b07060

  • Kim SJ, Zhao B, Im H, Min J, Choi N, Castro CM, Weissleder R, Lee H, Lee K Deep-learning based hologram classification for molecular diagnostics. bioRxiv. 2017;192559:ePub - DOI: 10.1101/192559

  • Park K, Kim H, Kim S, Lee K, Park S, Song J, Min C, Khanam F, Rashu R, Bhuiyan TR, Ryan ET, Qadri F, Weissleder R, Cheon J, Charles RC, Lee H Nano-Magnetic System For Rapid Diagnosis Of Acute Infection. ACS Nano. 2017;11(11):11425-11432 - PMID: 29121461 - PMCID: PMC6296367 - DOI: 10.1021/acsnano.7b06074

  • Min C, Park J, Mun JK, Lim Y, Min J, Lim JW, Kang DM, Ahn HK, Shin TH, Cheon J, Lee HS, Weissleder R, Castro CM, Lee H Integrated microHall magnetometer to measure the magnetic properties of nanoparticles. Lab Chip. 2017;17(23):4000-4007 - PMID: 29067383 - PMCID: PMC5698130 - DOI: 10.1039/c7lc00934h

  • Park J, Lin HY, Assaker JP, Jeong S, Huang CH, Kurdi A, Lee K, Fraser K, Min C, Eskandari S, Routray S, Tannous BA, Abdi R, Riella L, Chandraker A, Castro CM, Weissleder R, Lee H, Azzi JR Integrated Kidney Exosome Analysis (iKEA) For The Detection Of Kidney Transplant Rejection. ACS Nano. 2017;11(11):11041-11046 - PMID: 29053921 - PMCID: PMC6237084 - DOI: 10.1021/acsnano.7b05083

  • Im H, Yang K, Lee H, Castro CM Characterization of Extracellular Vesicles by Surface Plasmon Resonance. Methods Mol Biol. 2017;1660:133-141 - PMID: 28828653 - DOI: 10.1007/978-1-4939-7253-1_11

  • Lin HY, Huang CH, Park J, Pathania D, Castro CM, Fasano A, Weissleder R, Lee H Integrated Magneto-Chemical Sensor For On-Site Food Allergen Detection. ACS Nano. 2017;11(10):10062-10069 - PMID: 28792732 - DOI: 10.1021/acsnano.7b04318

  • Im H, Lee K, Weissleder R, Lee H, Castro CM Novel nanosensing technologies for exosome detection and profiling. Lab Chip. 2017;17(17):2892-2898 - PMID: 28745363 - PMCID: PMC5572557 - DOI: 10.1039/c7lc00247e

  • Jeong S, Eskandari R, Park SM, Alvarez J, Tee SS, Weissleder R, Kharas MG, Lee H, Keshari KR Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer. Sci Adv. 2017;3(6):e1700341 - PMID: 28630930 - PMCID: PMC5473678 - DOI: 10.1126/sciadv.1700341

  • Yang KS*, Im H*, Hong S, Pergolini I, Del Castillo AF, Wang R, Clardy S, Huang CH, Pille C, Ferrone S, Yang R, Castro CM, Lee H, Del Castillo CF, Weissleder R Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy. Sci Transl Med. 2017;9(391):eaal3226 - PMID: 28539469 - PMCID: PMC5846089 - DOI: 10.1126/scitranslmed.aal3226

  • Godlewski J, Ferrer-Luna R, Rooj AK, Mineo M, Ricklefs F, Takeda YS, Nowicki MO, Salińska E, Nakano I, Lee H, Weissleder R, Beroukhim R, Chiocca EA, Bronisz A MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer. Stem Cell Reports. 2017;8(6):1497-1505 - PMID: 28528698 - PMCID: PMC5470095 - DOI: 10.1016/j.stemcr.2017.04.024

  • Hong S, Park KS, Weissleder R, Castro CM, Lee H Facile silicification of plastic surface for bioassays. Chem Commun. 2017;53(13):2134-2137 - PMID: 28134385 - PMCID: PMC5327824 - DOI: 10.1039/c6cc09359k

  • Park YI, Kim E, Huang CH, Park KS, Castro CM, Lee H, Weissleder R Facile Coating Strategy to Functionalize Inorganic Nanoparticles for Biosensing. Bioconjug Chem. 2017;28(1):33-37 - PMID: 27792877 - PMCID: PMC5474933 - DOI: 10.1021/acs.bioconjchem.6b00524

  • Im H, Lee H, Castro CM Challenges influencing next generation technologies for precision medicine. Expert Rev Precis Med Drug Dev. 2016;1(2):121-123 - PMID: 28008420 - PMCID: PMC5166706 - DOI: 10.1080/23808993.2016.1165073

  • Gee MS, Ghazani AA, Haq R, Wargo JA, Sebas M, Sullivan RJ, Lee H, Weissleder R Point of care assessment of melanoma tumor signaling and metastatic burden from μNMR analysis of tumor fine needle aspirates and peripheral blood. Nanomedicine. 2016;13(3):821-828 - PMID: 27993725 - PMCID: PMC5392428 - DOI: 10.1016/j.nano.2016.12.006

  • Park KS, Chung HJ, Khanam F, Lee H, Rashu R, Bhuiyan MT, Berger A, Harris JB, Calderwood SB, Ryan ET, Qadri F, Weissleder R, Charles RC A magneto-DNA nanoparticle system for the rapid and sensitive diagnosis of enteric fever. Sci Rep. 2016;6:32878 - PMID: 27605393 - PMCID: PMC5015101 - DOI: 10.1038/srep32878

  • Hong S, Pirovich D, Kilcoyne A, Huang CH, Lee H, Weissleder R Supramolecular Metallo-Bioadhesive for Minimally Invasive Use. Adv Mater. 2016;28(39):8675-8680 - PMID: 27515068 - PMCID: PMC5144581 - DOI: 10.1002/adma.201602606

  • Pathania D*, Im H*, Kilcoyne A, Sohani AR, Fexon L, Pivovarov M, Abramson JS, Randall TC, Chabner BA, Weissleder R, Lee H, Castro CM Holographic Assessment of Lymphoma Tissue (HALT) for Global Oncology Field Applications. Theranostics. 2016;6(10):1603-10 - PMID: 27446494 - PMCID: PMC4955059 - DOI: 10.7150/thno.15534

  • Park KS*, Huang CH*, Lee K, Yoo YE, Castro CM, Weissleder R, Lee H Rapid identification of health care–associated infections with an integrated fluorescence anisotropy system. Sci Adv. 2016;2(5):e1600300 - PMID: 28861468 - PMCID: PMC5565941 - DOI: 10.1126/sciadv.1600300

  • Cho CF, Lee K, Speranza MC, Bononi FC, Viapiano MS, Luyt LG, Weissleder R, Chiocca EA, Lee H, Lawler SE Design of a microfluidic chip for magnetic-activated sorting of one-bead-one-compound libraries. ACS Comb Sci. 2016;18(6):271-8 - PMID: 27124678 - PMCID: PMC5321554 - DOI: 10.1021/acscombsci.5b00180

  • Song J, Leon Swisher C, Im H, Jeong S, Pathania D, Iwamoto Y, Pivovarov M, Weissleder R, Lee H Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography. Sci Rep. 2016;6:24681 - PMID: 27098438 - PMCID: PMC4838824 - DOI: 10.1038/srep24681

  • Miller MA, Oudin MJ, Sullivan RJ, Wang SJ, Meyer AS, Im H, Frederick DT, Tadros J, Griffith LG, Lee H, Weissleder R, Flaherty KT, Gertler FB, Lauffenburger DA Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance. Cancer Discov. 2016;6(4):382-99 - PMID: 26984351 - PMCID: PMC5087317 - DOI: 10.1158/2159-8290.CD-15-0933

  • Im H, Park YI, Pathania D, Castro CM, Weissleder R, Lee H Digital diffraction detection of protein markers for avian influenza. Lab Chip. 2016;16(8):1340-5 - PMID: 26980325 - PMCID: PMC4829473 - DOI: 10.1039/c5lc01558h

  • Jeong S, Park J, Pathania D, Castro CM, Weissleder R, Lee H Integrated Magneto-Electrochemical Sensor for Exosome Analysis. ACS Nano. 2016;10(2):1802-1809 - PMID: 26808216 - PMCID: PMC4802494 - DOI: 10.1021/acsnano.5b07584

  • Hong S, Carlson J, Lee H, Weissleder R Bioorthogonal Radiopaque Hydrogel for Endoscopic Delivery and Universal Tissue Marking. Adv Healthc Mater. 2015;5(4):421-426 - PMID: 26688173 - PMCID: PMC4811597 - DOI: 10.1002/adhm.201500780

  • Park KS, Charles RC, Ryan ET, Weissleder R*, Lee H* Fluorescence polarization-based nucleic acid testing for rapid and cost-effective diagnosis of infectious disease. Chem Eur J. 2015;21(46):16359-63 - PMID: 26420633 - PMCID: PMC4816641 - DOI: 10.1002/chem.201502934

  • Lee H, Shin TH, Cheon J, Weissleder R Recent Developments in Magnetic Diagnostic Systems. Chem Rev. 2015;115(19):10690-724 - PMID: 26258867 - PMCID: PMC5791529 - DOI: 10.1021/cr500698d

  • Chung HJ, Pellegrini KL, Chung J, Wanigasuriya K, Jayawardene I, Lee K, Lee H, Vaidya VS, Weissleder R Nanoparticle Detection of Urinary Markers for Point-of-Care Diagnosis of Kidney Injury. PLoS ONE. 2015;10(7):e0133417 - PMID: 26186708 - PMCID: PMC4506142 - DOI: 10.1371/journal.pone.0133417

  • Park YI, Im H, Weissleder R, Lee H Nanostar clustering improves the sensitivity of plasmonic assays. Bioconjug Chem. 2015;26(8):1470-1474 - PMID: 26102604 - PMCID: PMC5292976 - DOI: 10.1021/acs.bioconjchem.5b00343

  • Glenn DR#, Lee K#, Park H, Weissleder R, Yacoby A, Lukin MD, Lee H*, Walsworth RL*, Connolly CB* Single-cell magnetic imaging using a quantum diamond microscope. Nat Methods. 2015;12(8):736-738 - PMID: 26098019 - PMCID: PMC4521973 - DOI: 10.1038/nmeth.3449

  • Turetsky A, Lee K, Song J, Giedt RJ, Kim E, Kovach AE, Hochberg EP, Castro CM, Lee H, Weissleder R On chip analysis of CNS lymphoma in cerebrospinal fluid. Theranostics. 2015;5(8):796-804 - PMID: 26000053 - PMCID: PMC4440438 - DOI: 10.7150/thno.11220

  • Shao H, Chung J, Lee K, Balaj L, Min C, Carter BS, Hochberg FH, Breakefield XO, Lee H*, Weissleder R* Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma. Nat Commun. 2015;6:6999 - PMID: 25959588 - PMCID: PMC4430127 - DOI: 10.1038/ncomms7999

  • Im H, Shao H, Weissleder R, Castro CM, Lee H Nano-plasmonic exosome diagnostics. Expert Rev Mol Diagn. 2015;15(6):725-33 - PMID: 25936957 - PMCID: PMC4675626 - DOI: 10.1586/14737159.2015.1041378

  • Im H, Castro CM, Shao H, Liong M, Song J, Pathania D, Fexon L, Min C, Avila-Wallace M, Zurkiya O, Rho J, Magaoay B, Tambouret RH, Pivovarov M, Weissleder R*, Lee H* Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone. Proc Natl Acad Sci U S A. 2015;112(18):5613-8 - PMID: 25870273 - PMCID: PMC4426451 - DOI: 10.1073/pnas.1501815112

  • Chen S, Sanjana NE, Zheng K, Shalem O, Lee K, Shi X, Scott DA, Song J, Pan JQ, Weissleder R, Lee H, Zhang F, Sharp PA Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis. Cell. 2015;160(6):1246-60 - PMID: 25748654 - PMCID: PMC4380877 - DOI: 10.1016/j.cell.2015.02.038

  • Lee K, Shao H, Weissleder R, Lee H Acoustic Purification of Extracellular Microvesicles. ACS Nano. 2015;9(3):2321-7 - PMID: 25672598 - PMCID: PMC4373978 - DOI: 10.1021/nn506538f

  • Issadore D, Park YI, Shao H, Min C, Lee K, Liong M, Weissleder R*, Lee H* Magnetic sensing technology for molecular analyses. Lab Chip. 2014;14(14):2385-97 - PMID: 24887807 - PMCID: PMC4098149 - DOI: 10.1039/c4lc00314d

  • Im H*, Shao H*, Park YI, Peterson VM, Castro CM, Weissleder R*, Lee H* Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor. Nat Biotechnol. 2014;32(5):490-5 - PMID: 24752081 - PMCID: PMC4356947 - DOI: 10.1038/nbt.2886

  • Liong M, Im H, Majmudar MD, Aguirre AD, Sebas M, Lee H*, Weissleder R* Magnetic Ligation Method for Quantitative Detection of MicroRNAs. Adv Healthc Mater. 2014;3(7):1015-9 - PMID: 24532323 - PMCID: PMC4107040 - DOI: 10.1002/adhm.201300672

  • Chapman S, Dobrovolskaia M, Farahani K, Goodwin A, Joshi A, Lee H, Meade T, Pomper M, Ptak K, Rao J, Singh R, Sridhar S, Stern S, Wang A, Weaver JB, Woloschak G, Yang L Nanoparticles for cancer imaging: The good, the bad, and the promise. Nano Today. 2013;8(5):454-460 - PMID: 25419228 - PMCID: PMC4240321 - DOI: 10.1016/j.nantod.2013.06.001

  • Rho J, Chung J, Im H, Liong M, Shao H, Castro CM, Weissleder R, Lee H Magnetic Nanosensor for Detection and Profiling of Erythrocyte-Derived Microvesicles. ACS Nano. 2013;7(12):11227-33 - PMID: 24295203 - PMCID: PMC3898036 - DOI: 10.1021/nn405016y

  • Peterson VM*, Castro CM*, Chung J, Miller NC, Ullal AV, Castano MD, Penson RT, Lee H, Birrer MJ, Weissleder R Ascites analysis by a microfluidic chip allows tumor-cell profiling. Proc Natl Acad Sci U S A. 2013;110(51):E4978-86 - PMID: 24297935 - PMCID: PMC3870756 - DOI: 10.1073/pnas.1315370110

  • Ghazani A, Pectasides M, Sharma A, Castro CM, Mino-Kenudson M, Lee H, Shepard JA, Weissleder R Molecular characterization of scant lung tumor cells using iron-oxide nanoparticles and micro-nuclear magnetic resonance. Nanomedicine. 2013;10 :661-668 - PMID: 24200523 - PMCID: PMC3966960 - DOI: 10.1016/j.nano.2013.10.008

  • Chung J*, Issadore D*, Ullal A*, Lee K, Weissleder R*, Lee H* Rare cell isolation and profiling on a hybrid magnetic/size-sorting chip. Biomicrofluidics. 2013;7(5):54107 - PMID: 24404070 - PMCID: PMC3790798 - DOI: 10.1063/1.4821923

  • Yoon TJ, Shao H, Weissleder R, Lee H Oxidation Kinetics and Magnetic Properties of Elemental Iron Nanoparticles. Part. Part. Syst. Charact. 2013;30:667–671 - PMID: 24077230 - PMCID: PMC3783348 - DOI: 10.1002/ppsc.201300013

  • Chung HJ, Castro CM, Im H, Lee H*, Weissleder R* A magneto-DNA nanoparticle system for rapid detection and phenotyping of bacteria. Nat Nanotechnol. 2013;8(5):369-75 - PMID: 23644570 - PMCID: PMC3711657 - DOI: 10.1038/nnano.2013.70

  • Liong M, Hoang AN, Chung J, Gural N, Ford CB, Min C, Shah RR, Ahmad R, Fernandez-Suarez M, Fortune SM, Toner M, Lee H*, Weissleder R* Magnetic barcode assay for genetic detection of pathogens. Nat Commun. 2013;4:1752 - PMID: 23612293 - PMCID: PMC3635151 - DOI: 10.1038/ncomms2745

  • Ghazani AA, McDermott S, Pectasides M, Sebas M, Mino-Kenudson M, Lee H, Weissleder R, Castro CM Comparison of select cancer biomarkers in human circulating and bulk tumor cells using magnetic nanoparticles and miniaturized micro-NMR system. Nanomedicine (Lond). 2013;9(7):1009-17 - PMID: 23570873 - PMCID: PMC4330975 - DOI: 10.1016/j.nano.2013.03.011

  • Issadore D*, Chung HJ*, Chung J, Budin G, Weissleder R*, Lee H* μHall Chip for Sensitive Detection of Bacteria. Adv Healthc Mater. 2013;2(9):1224-8 - PMID: 23495188 - PMCID: PMC4340655 - DOI: 10.1002/adhm.201200380

  • Shao H, Chung J, Balaj L, Charest A, Bigner DD, Carter BS, Hochberg FH, Breakefield XO, Weissleder R*, Lee H* Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy. Nature Med. 2012;18(12):1835-1840 - PMID: 23142818 - PMCID: PMC3518564 - DOI: 10.1038/nm.2994

  • Agasti SS, Liong M, Peterson VM, Lee H, Weissleder R Photocleavable DNA barcode-antibody conjugates allow sensitive and multiplexed protein analysis in single cell. J Am Chem Soc. 2012;134(45):18499-18502 - PMID: 23092113 - PMCID: PMC3498844 - DOI: 10.1021/ja307689w

  • Agasti SS, Kohler RH, Liong M, Peterson VM, Lee H, Weissleder R Dual Imaging and Photoactivated Nanoprobe for Controlled Cell Tracking. Small. 2012;9(2):222-7 - PMID: 22996932 - PMCID: PMC3552149 - DOI: 10.1002/smll.201201007

  • Chung J*, Shao H*, Reiner T, Issadore D, Weissleder R, Lee H Cell Sorting: Microfluidic Cell Sorter (μFCS) for On-chip Capture and Analysis of Single Cells. Adv Healthc Mater. 2012;1(4):432-6 - PMID: 23184773 - PMCID: PMC3508764 - DOI: 10.1002/adhm.201200046

  • Min C, Shao H, Liong M, Yoon TJ, Weissleder R, Lee H Mechanism of Magnetic Relaxation Switching Sensing. ACS Nano. 2012;6(8):6821-8 - PMID: 22762250 - PMCID: PMC3429660 - DOI: 10.1021/nn301615b

  • Issadore D, Chung J*, Shao H*, Liong M, Ghazani AA, Castro CM, Weissleder R*, Lee H* Ultrasensitive Clinical Enumeration of Rare Cells ex Vivo Using a Micro-Hall Detector. Sci Transl Med. 2012;4 (141):141ra92 - PMID: 22764208 - PMCID: PMC3603277 - DOI: 10.1126/scitranslmed.3003747

  • Budin G*, Chung HJ*, Lee H, Weissleder R A Magnetic Gram Stain for Bacterial Detection. Angew Chem Int Ed Engl. 2012;51(31):7752-5 - PMID: 22744868 - PMCID: PMC3496380 - DOI: 10.1002/anie.201202982

  • Ghazani AA, Castro CM, Gorbatov R, Lee H, Weissleder R Sensitive and Direct Detection of Circulating Tumor Cells by Multimarker µ-Nuclear Magnetic Resonance. Neoplasia. 2012;14(5):388-95 - PMID: 22745585 - PMCID: PMC3384426 - DOI: 10.1596/neo.12696

  • Peterson VM, Castro CM, Lee H, Weissleder R Orthogonal Amplification of Nanoparticles for Improved Diagnostic Sensing. ACS Nano. 2012;6(4):3506-13 - PMID: 22424443 - PMCID: PMC3337350 - DOI: 10.1021/nn300536y

  • Shao H, Min C, Issadore D, Liong M, Yoon TJ, Weissleder R, Lee H Magnetic Nanoparticles and microNMR for Diagnostic Applications. Theranostics. 2012;2(1):55-65 - PMID: 22272219 - PMCID: PMC3263516 - DOI: 10.7150/thno.3465

  • Agasti SS, Liong M, Tassa C, Chung HJ, Shaw SY, Lee H, Weissleder R Supramolecular Host-Guest Interaction for Labeling and Detection of Cellular Biomarkers. Angew Chem Int Ed Engl. 2011;51(2):450-4 - PMID: 22113923 - PMCID: PMC3309171 - DOI: 10.1002/anie.201105670

  • Liong M, Fernandez-Suarez M, Issadore D, Min C, Tassa C, Reiner T, Fortune SM, Toner M, Lee H, Weissleder R Specific Pathogen Detection Using Bioorthogonal Chemistry and Diagnostic Magnetic Resonance. Bioconjug Chem. 2011;22(12):2390-4 - PMID: 22043803 - PMCID: PMC3263317 - DOI: 10.1021/bc200490r

  • Ullal AV, Reiner T, Yang KS, Gorbatov R, Min C, Issadore D, Lee H, Weissleder R Nanoparticle Mediated Measurement of Target-Drug Binding in Cancer Cells. ACS Nano. 2011;5(11):9216-24 - PMID: 21962084 - PMCID: PMC3297118 - DOI: 10.1021/nn203450p

  • Chung H, Reiner T, Budin G, Min C, Liong M, Issadore D, Lee H, Weissleder R Ubiquitous Detection of Gram-Positive Bacteria with Bioorthogonal Magnetofluorescent Nanoparticles. ACS Nano. 2011;5(11):8834-41 - PMID: 21967150 - PMCID: PMC3222727 - DOI: 10.1021/nn2029692

  • Yoon TJ*, Lee H*, Shao H, Hilderbrand SA, Weissleder R Multicore Assemblies Potentiate Magnetic Properties of Biomagnetic Nanoparticles. Adv Mater. 2011;23(41):4793-7 - PMID: 21953810 - PMCID: PMC3224986 - DOI: 10.1002/adma.201102948

  • Liong M, Tassa C, Shaw SY, Lee H, Weissleder R Multiplexed Magnetic Labeling Amplification Using Oligonucleotide Hybridization. Adv Mater. 2011;23(36):H254-7 - PMID: 21780311 - PMCID: PMC3584698 - DOI: 10.1002/adma.201101401

  • Yoon TJ*, Lee H*, Shao H, Weissleder R Highly magnetic core-shell nanoparticles with a unique magnetization mechanism. Angew Chem Int Ed Engl. 2011;50(20):4663-6 - PMID: 21495138 - PMCID: PMC3334859 - DOI: 10.1002/anie.201100101

  • Issadore D, Min C, Liong M, Chung J, Weissleder R, Lee H Miniature magnetic resonance system for point-of-care diagnostics. Lab Chip. 2011;11(13):2282-7 - PMID: 21547317 - PMCID: PMC3115660 - DOI: 10.1039/c1lc20177h

  • Haun JB, Yoon TJ, Lee H, Weissleder R Molecular Detection of Biomarkers and Cells Using Magnetic Nanoparticles and Diagnostic Magnetic Resonance. Methods Mol Biol. 2011;726:33-49 - PMID: 21424441 - DOI: 10.1007/978-1-61779-052-2_3

  • Haun J, Devaraj NK, Marinelli B, Lee H, Weissleder R Probing Intracellular Biomarkers and Mediators of Cell Activation Using Nanosensors and Bioorthogonal Chemistry. ACS Nano. 2011;5(4):3204-13 - PMID: 21351804 - PMCID: PMC3088084 - DOI: 10.1021/nn200333m

  • Haun JB*, Castro CM*, Wang R, Peterson VM, Marinelli BS, Lee H, Weissleder R. Micro-NMR for Rapid Molecular Analysis of Human Tumor Samples . Sci Transl Med. 2011;3(71):71ra16 - PMID: 21346169 - PMCID: PMC3086073 - DOI: 10.1126/scitranslmed.3002048

  • Sun N, Yoon TJ, Lee H, Andress W, Weissleder R, Ham D Palm NMR and 1-Chip NMR. IEEE J Solid-ST Circ. 2011;46(1):342-352

  • Shao H, Yoon TJ, Liong M, Weissleder R, Lee H Magnetic nanoparticles for biomedical NMR-based diagnostics. Beilstein J Nanotechnol. 2010;1:142154 - PMID: 21977404 - PMCID: PMC3045933 - DOI: 10.3762/bjnano.1.17

  • Liong M, Shao H, Haun JB, Lee H, Weissleder R Carboxymethylated Polyvinyl Alcohol Stabilizes Doped Ferrofluids for Biological Applications. Adv Mater. 2010;22(45):5168-72 - PMID: 20859943 - PMCID: PMC2993874 - DOI: 10.1002/adma.201002219

  • Haun JB, Devaraj NK, Hilderbrand SA, Lee H, Weissleder R Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection. Nat Nanotechnol. 2010;5(9):660-5 - PMID: 20676091 - PMCID: PMC2934903 - DOI: 10.1038/nnano.2010.148

  • Haun JB, Yoon TJ, Lee H, Weissleder R Magnetic nanoparticle biosensors. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010;2(3):291-304 - PMID: 20336708 - DOI: 10.1002/wnan.84

  • Lee H*, Yoon TJ*, Figueiredo JL, Swirski FK, Weissleder R Rapid detection and profiling of cancer cells in fine-needle aspirates. Proc Natl Acad Sci U S A. 2009;106 (30):12459-12464 - PMID: 19620715 - PMCID: PMC2718371 - DOI: 10.1073/pnas.0902365106

  • Lee H*, Yoon TJ*, Weissleder R Ultrasensitive Detection of Bacteria Using Core-Shell Nanoparticles and an NMR-Filter System. Angew Chem Int Ed Engl. 2009;48(31):5657-60 - PMID: 19554581 - PMCID: PMC2453069 - DOI: 10.1002/anie.200901791

  • Wildgruber M, Lee H, Chudnovskiy A, Yoon T, Etzrodt M, Pittet M, Nahrendorf M, Croce K, Libby P, Weissleder R, Swirski F Monocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensors. PLoS ONE. 2009;4(5):e5663 - PMID: 19461894 - PMCID: PMC2680949 - DOI: 10.1371/journal.pone.0005663

  • Sun N, Liu Y, Lee H, Weissleder R, Ham D CMOS RF Biosensor Utilizing Nuclear Magnetic Resonance. IEEE J Solid-ST Circ. 2009;44:1629-1643

  • Insin N, Tracy JB, Lee H, Zimmer JP, Westervelt RM, Bawendi MG Incorporation of iron oxide nanoparticles and quantum dots into silica microspheres. ACS Nano. 2008;2(2):197-202 - PMID: 19206619 - DOI: 10.1021/nn700344x

  • Lee H, Sun E, Ham D, Weissleder R Chip-NMR biosensor for detection and molecular analysis of cells. Nature Med. 2008;14(8):869-74 - PMID: 18607350 - PMCID: PMC2729055 - DOI: 10.1038/nm.1711

  • Lee H, Liu Y, Ham D, Westervelt RM Integrated cell manipulation system--CMOS/microfluidic hybrid. Lab Chip. 2007;7(3):331-7 - PMID: 17330164 - DOI: 10.1039/b700373k

  • Lee H, Purdon AM, Chu V, Westervelt RM Controlled Assembly of Magnetic Nanoparticles from Magnetotactic Bacteria Using Microelectromagnets Arrays. Nano Lett. 0;4(5):995

  • Lee H, Purdon AM, Westervelt RM Manipulation of biological cells using a microelectromagnet matrix. Appl Phys Lett. 0;85(6):1063-65

  • Lee H, Purdon AM, Westervelt RM Micromanipulation of biological systems with microelectromagnets. IEEE T Magn. 0;40(4):2991 - 2993

  • Hunt TP, Lee H, and Westervelt RM Addressable micropost array for the dielectrophoretic manipulation of particles in fluid. Appl Phys Lett. 0;85(26):6421-23