About
Hakho Lee's Lab
Our lab focuses on developing new diagnostic technology. Especially, we seek to combine multidisciplinary fields to implement highly sensitive lab-on-a-chip systems. The research topics include:
- Nanomaterials: Synthesis and comprehensive characterization
- Microfluidics: Design and optimization for high throughput operation
- Microelectronics: Miniaturized, embedded electric/magnetic sensors
Our diagnostic platforms have been used to identify serum disease markers, to rapidly detect tuberculosis without culture, and to molecularly profile cancer cells. The current research aims at the facile and speedy detection of individual cells on a chip.
Recent Publications (more...)
Rapid detection and profiling of cancer cells in fine-needle aspirates.
P Natl Acad Sci U S A. 2009;106 (30):12459-12464 - PMID: 19620715 - PMCID: PMC2718371
Ultrasensitive Detection of Bacteria Using Core-Shell Nanoparticles and an NMR-Filter System.
Angew Chem Int Edit. 2009;48(31):5657-60 - PMID: 19554581 - PMCID: PMC2453069
Monocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensors.
PLoS ONE. 2009;4(5):e5663 - PMID: 19461894 - PMCID: PMC2680949
Recent News (more...)
2009-11-09: Nature Nanotechnology Feature article describes CSB work on TB detection using magnetic nanoparticles, microfluidics and nuclear magnetic resonance. (pdf)
2009-08-09: CSB's work on TB detection using DMR technology is featured in New Scientist (pdf) and MIT Technology Review (pdf)
2009-07-22: Bloomberg News describes application of CSBs DMR chip for cancer detection - A rapid test for cancer using tiny magnetic sensors was able to detect as few as two cancer cells in a sample of human tissue within 15 minutes, a study said. (pdf)