Sort by:
Kang M, Quintana J, Hu H, Teixeira VC, Olberg S, Banla LI, Rodriguez V, Hwang WL, Schuemann J, Parangi S, Weissleder R, Miller MA
Sustained and Localized Drug Depot Release using Radiation-Activated Scintillating Nanoparticles.
Adv Mater. 2024;:e2312326 - PMID: 38389502 - DOI: 10.1002/adma.202312326
Bianchi A, De Castro Silva I, Deshpande NU, Singh S, Mehra S, Garrido VT, Guo X, Nivelo LA, Kolonias DS, Saigh SJ, Wieder E, Rafie CI, Dosch AR, Zhou Z, Umland O, Amirian H, Ogobuiro IC, Zhang J, Ban Y, Shiau C, Nagathihalli NS, Montgomery EA, Hwang WL, Brambilla R, Komanduri K, Villarino AV, Toska E, Stanger BZ, Gabrilovich DI, Merchant NB, Datta J
Cell-autonomous Cxcl1 sustains tolerogenic circuitries and stromal inflammation via neutrophil-derived TNF in pancreatic cancer.
Cancer Discov. 2023;13(6):1428-1453 - PMID: 36946782 - PMCID: PMC10259764 - DOI: 10.1158/2159-8290.CD-22-1046
Cephas AT, Hwang WL, Maitra A, Parnas O, DelGiorno KE
It is better to light a candle than to curse the darkness: single-cell transcriptomics sheds new light on pancreas biology and disease.
Gut. 2023;72(6):1211-1219 - PMID: 36997301 - PMCID: PMC10988578 - DOI: 10.1136/gutjnl-2022-329313
Hwang WL, Su J, Shiau C, Wang PL, Guo JA, Lester NA, Barth JL, Hoffman HI, Aguirre A, Hong TS, Wo JY, Ting D, Zheng L, Mino-Kenudson M, Jacks T
Molecular Mechanisms of Intratumoral Nerve Recruitment and Perineural Invasion Elucidated with Spatial Transcriptomics and CRISPR Activation.
Int J Radiat Oncol Biol Phys. 2023;117(2S):S21 - PMID: 37784453 - DOI: 10.1016/j.ijrobp.2023.06.244
Shiau C, Cao J, Gregory MT, Gong D, Yin X, Cho JW, Wang PL, Su J, Wang S, Reeves JW, Kim TK, Kim Y, Guo JA, Lester NA, Schurman N, Barth JL, Weissleder R, Jacks T, Qadan M, Hong TS, Wo JY, Roberts H, Beechem JM, Fernandez-Del Castillo C, Mino-Kenudson M, Ting DT, Hemberg M, Hwang WL
Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysis.
bioRxiv. 2023;:ePub - PMID: 37425692 - PMCID: PMC10327107 - DOI: 10.1101/2023.06.28.546848
Shi DD, Guo JA, Hoffman HI, Su J, Mino-Kenudson M, Barth JL, Schenkel JM, Loeffler JS, Shih HA, Hong TS, Wo JY, Aguirre AJ, Jacks T, Zheng L, Wen PY, Wang TC, Hwang WL
Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities.
Lancet Oncol. 2022;23(2):e62-e74 - PMID: 35114133 - PMCID: PMC9516432 - DOI: 10.1016/S1470-2045(21)00596-9
Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi SL, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J, Shiau C, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco MS, Nguyen L, Delorey T, Phillips D, Barth JL, Kem M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgji V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem JM, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Castillo CF, Liss AS, Ting DT, Jacks T, Regev A
Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.
Nat Genet. 2022;54(8):1178-1191 - PMID: 35902743 - PMCID: PMC10290535 - DOI: 10.1038/s41588-022-01134-8 - Cover
Ozturk H, Cingoz H, Tufan T, Yang J, Adair SJ, Tummala KS, Kuscu C, Kinali M, Comertpay G, Nagdas S, Goudreau BJ, Luleyap HU, Bingul Y, Ware TB, Hwang WL, Hsu KL, Kashatus DF, Ting DT, Chandel NS, Bardeesy N, Bauer TW, Adli M
ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer.
Dev Cell. 2022;57(11):1331-1346.e9 - PMID: 35508175 - DOI: 10.1016/j.devcel.2022.04.014
Seldon CS, Meiyappan K, Hoffman H, Guo JA, Goel N, Hwang WL, Nguyen PL, Mahal BA, Alshalalfa M
Genomic alterations predictive of poor clinical outcomes in pan-cancer.
Oncotarget. 2022;13:1069-1077 - PMID: 36187555 - PMCID: PMC9518688 - DOI: 10.18632/oncotarget.28276
Shiau C, Su J, Guo JA, Hong TS, Wo JY, Jagadeesh KA, Hwang WL
Treatment-associated remodeling of the pancreatic cancer endothelium at single-cell resolution.
Front Oncol. 2022;12:929950 - PMID: 36185212 - PMCID: PMC9524152 - DOI: 10.3389/fonc.2022.929950
Guo JA, Alshalalfa M, Kim DY, Hoffman HI, Shiau C, Su J, Hwang WL, Mahal BA
DNA repair and immune checkpoint blockade response.
Cancer Genet. 2022;264-265:1-4 - PMID: 35245846 - DOI: 10.1016/j.cancergen.2022.02.007
Burger ML, Cruz AM, Crossland GE, Gaglia G, Ritch CC, Blatt SE, Bhutkar A, Canner D, Kienka T, Tavana SZ, Barandiaran AL, Garmilla A, Schenkel JM, Hillman M, de Los Rios Kobara I, Li A, Jaeger AM, Hwang WL, Westcott PMK, Manos MP, Holovatska MM, Hodi FS, Regev A, Santagata S, Jacks T
Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors.
Cell. 2021;184(19):4996-5014.e26 - PMID: 34534464 - PMCID: PMC8522630 - DOI: 10.1016/j.cell.2021.08.020
Schenkel JM, Herbst RH, Canner D, Li A, Hillman M, Shanahan SL, Gibbons G, Smith OC, Kim JY, Westcott P, Hwang WL, Freed-Pastor WA, Eng G, Cuoco MS, Rogers P, Park JK, Burger ML, Rozenblatt-Rosen O, Cong L, Pauken KE, Regev A, Jacks T
Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes.
Immunity. 2021;54(10):2338-2353.e6 - PMID: 34534439 - PMCID: PMC8604155 - DOI: 10.1016/j.immuni.2021.08.026
Freed-Pastor WA, Lambert LJ, Ely ZA, Pattada NB, Bhutkar A, Eng G, Mercer KL, Garcia AP, Lin L, Rideout WM, Hwang WL, Schenkel JM, Jaeger AM, Bronson RT, Westcott PMK, Hether TD, Divakar P, Reeves JW, Deshpande V, Delorey T, Phillips D, Yilmaz OH, Regev A, Jacks T
The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer.
Cancer Cell. 2021;39(10):1342-1360.e14 - PMID: 34358448 - PMCID: PMC8511341 - DOI: 10.1016/j.ccell.2021.07.007
Guo JA, Hoffman HI, Shroff SG, Chen P, Hwang PG, Kim DY, Kim DW, Cheng SW, Zhao D, Mahal BA, Alshalalfa M, Niemierko A, Wo JY, Loeffler JS, Fernandez-Del Castillo C, Jacks T, Aguirre AJ, Hong TS, Mino-Kenudson M, Hwang WL
Pan-cancer Transcriptomic Predictors of Perineural Invasion Improve Occult Histopathologic Detection.
Clin Cancer Res. 2021;27(10):2807-2815 - PMID: 33632928 - PMCID: PMC8127360 - DOI: 10.1158/1078-0432.CCR-20-4382
Guo JA, Hoffman HI, Weekes CD, Zheng L, Ting DT, Hwang WL
Refining the Molecular Framework for Pancreatic Cancer with Single-cell and Spatial Technologies.
Clin Cancer Res. 2021;27(14):3825-3833 - PMID: 33653818 - PMCID: PMC8282742 - DOI: 10.1158/1078-0432.CCR-20-4712
Swami N, Hwang WL, Guo JA, Hoffman H, Abramowitz MC, Elbakouny Z, Beltran H, Chipidza F, Choueiri T, Pra AD, Huang F, Kaochar S, Kantoff P, Kim DW, Kishan AU, Kobetz E, Marinac C, Mucci LA, Muralidhar V, Pollack A, Sanford NN, Schaeffer EM, Spratt DE, Zhao SG, Rebbeck TR, Nguyen PL, Feng FY, Mahal BA, Alshalalfa M
Novel genomic signature predictive of response to immune checkpoint blockade: A pan-cancer analysis from project Genomics Evidence Neo-plasia Information Exchange (GENIE).
Cancer Genet. 2021;258-259:61-68 - PMID: 34551377 - DOI: 10.1016/j.cancergen.2021.08.004
Lebow ES, Hwang WL, Zieminski S, Wang Y, Niemierko A, Mehan WA, Oh KS, Khandekar M, Willers H, Shih HA
Early experience with hippocampal avoidance whole brain radiation therapy and simultaneous integrated boost for brain metastases.
J Neurooncol. 2020;148(1):81-88 - PMID: 32307637 - DOI: 10.1007/s11060-020-03491-y
Kim DW, Buzurovic IM, Mahal BV, Hwang W, Oladeru OT, O'Farrell DA, Harris TC, Margalit DN, Lam M, Devlin PM
Combined interstitial and surface high-dose-rate brachytherapy treatment of squamous cell carcinoma of the hand.
J Contemp Brachytherapy. 2020;12(1):48-52 - PMID: 32190070 - PMCID: PMC7073341 - DOI: 10.5114/jcb.2020.92408
Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi S, Schapiro D, Reeves J, Zollinger DR, Eng G, Schenkel JM, Freed-Pastor WA, Rodrigues C, Gould J, Lambden C, Porter C, Tsankov A, Dionne D, Abbondanza D, Waldman J, Cuoco M, Nguyen L, Delorey T, Phillips D, Ciprani D, Kern M, Mehta A, Fuhrman K, Fropf R, Beechem J, Loeffler JS, Ryan DP, Weekes CD, Ting DT, Ferrone CR, Wo JY, Hong TS, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Fernandez-del Castillo C, Liss AS, Jacks TE, Regev A
Single-nucleus and spatial transcriptomics of archival pancreatic cancer reveals multi-compartment reprogramming after neoadjuvant treatment
bioRxiv. 2020;:ePub - DOI: 10.1101/2020.08.25.267336
Pike LRG, Royce TJ, Mahal AR, Kim DW, Hwang WL, Mahal BA, Sanford NN
Outcomes of HPV-Associated Squamous Cell Carcinoma of the Head and Neck: Impact of Race and Socioeconomic Status.
J Natl Compr Canc Netw. 2020;18(2):177-184 - PMID: 32023531 - PMCID: PMC7384230 - DOI: 10.6004/jnccn.2019.7356
Hoffman HI, Guo JA, Hawkins MA, Bridgewater JA, Wo JY, Hong TS, Hwang WL
Silver Linings: An Opportunity to Improve Clinical Paradigms After the COVID-19 Pandemic.
JCO Oncol Pract. 2020;16(9):532-534 - PMID: 32469687 - DOI: 10.1200/OP.20.00335
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR
Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma.
CA Cancer J Clin. 2020;70(5):375-403 - PMID: 32683683 - PMCID: PMC7722002 - DOI: 10.3322/caac.21626
Mehta A, Hwang WL, Weekes C
The present and future of systemic and microenvironment-targeted therapy for pancreatic adenocarcinoma.
Ann Pancreat Cancer. 2020;3:ePub - PMID: 33294843 - PMCID: PMC7720884 - DOI: 10.21037/apc-2020-pda-05
Hwang WL, Wolfson RL, Niemierko A, Marcus KJ, DuBois SG, Haas-Kogan D
Clinical Impact of Tumor Mutational Burden in Neuroblastoma.
J Natl Cancer Inst. 2019;111(7):695-699 - PMID: 30307503 - PMCID: PMC6624164 - DOI: 10.1093/jnci/djy157
Niyazi M, Niemierko A, Paganetti H, Söhn M, Schapira E, Goldberg S, Adams J, Kim V, Oh KS, Hwang WL, Lu HM, Belka C, Busse PM, Loeffler JS, Shih HA
Volumetric and actuarial analysis of brain necrosis in proton therapy using a novel mixture cure model.
Radiother Oncol. 2019;142:154-161 - PMID: 31563411 - DOI: 10.1016/j.radonc.2019.09.008
Sanford NN, Hwang WL, Pike LRG, Lam AC, Royce TJ, Mahal BA
Trimodality therapy for HPV-positive oropharyngeal cancer: A population-based study: Trimodality therapy for HPV+ OPC.
Oral Oncol. 2019;98:28-34 - PMID: 31536843 - PMCID: PMC7358785 - DOI: 10.1016/j.oraloncology.2019.09.009
Liu KX, Lamba N, Hwang WL, Niemierko A, DuBois SG, Haas-Kogan DA
Risk stratification by somatic mutation burden in Ewing sarcoma.
Cancer. 2019;125(8):1357-1364 - PMID: 30602061 - DOI: 10.1002/cncr.31919
Lamba N, Hwang WL, Kim DW, Niemierko A, Marciscano AE, Mehan WA, Benayoun MD, Curry WT, Barker FG, Martuza RL, Dunn IF, Claus E, Bi WL, Aizer AA, Alexander BM, Oh KS, Loeffler JS, Shih HA
Atypical Histopathological Features and the Risk of Treatment Failure in Nonmalignant Meningiomas: A Multi-Institutional Analysis.
World Neurosurg. 2019;133:e804-e812 - PMID: 31605839 - DOI: 10.1016/j.wneu.2019.10.002
Hwang WL, Niemierko A, Hwang KL, Hubbeling H, Schapira E, Gainor JF, Keane FK
Clinical Outcomes in Patients With Metastatic Lung Cancer Treated With PD-1/PD-L1 Inhibitors and Thoracic Radiotherapy.
JAMA Oncol. 2018;4(2):253-255 - PMID: 28973343 - PMCID: PMC5838581 - DOI: 10.1001/jamaoncol.2017.3808
Hwang WL, Tendulkar RD, Niemierko A, Agrawal S, Stephans KL, Spratt DE, Hearn JW, Koontz BF, Lee WR, Michalski JM, Pisansky TM, Liauw SL, Abramowitz MC, Pollack A, Moghanaki D, Anscher MS, Den RB, Zietman AL, Stephenson AJ, Efstathiou JA
Comparison Between Adjuvant and Early-Salvage Postprostatectomy Radiotherapy for Prostate Cancer With Adverse Pathological Features.
JAMA Oncol. 2018;4(5):e175230 - PMID: 29372236 - PMCID: PMC5885162 - DOI: 10.1001/jamaoncol.2017.5230
Hwang WL, Niemierko A, Efstathiou JA
Comparing Adjuvant vs Early-Salvage Radiotherapy After Radical Prostatectomy-Reply.
JAMA Oncol. 2018;4(11):1620-1621 - PMID: 30422248 - DOI: 10.1001/jamaoncol.2018.3552
Hwang WL, Pleskow HM, Miyamoto DT
Molecular analysis of circulating tumors cells: Biomarkers beyond enumeration.
Adv Drug Deliv Rev. 2018;125:122-131 - PMID: 29326053 - DOI: 10.1016/j.addr.2018.01.003
Sanford NN, Mahal BA, Royce TJ, Pike LRG, Hwang WL
Sex Disparity and Copy Number Alterations in Esophageal Squamous Cell Carcinoma.
Clin Gastroenterol Hepatol. 2018;17(6):1207-1209 - PMID: 30120994 - DOI: 10.1016/j.cgh.2018.08.026
Pike LRG, Hwang WL, Royce TJ, Sanford NN, Mahal BA
HPV status predicts for improved survival following chemotherapy in metastatic squamous cell carcinoma of the oropharynx.
Oral Oncol. 2018;86:69-74 - PMID: 30409322 - DOI: 10.1016/j.oraloncology.2018.09.007
Hwang WL, Pike LRG, Royce TJ, Mahal BA, Loeffler JS
Safety of combining radiotherapy with immune-checkpoint inhibition.
Nat Rev Clin Oncol. 2018;15(8):477-494 - PMID: 29872177 - DOI: 10.1038/s41571-018-0046-7
Kim D, Niemierko A, Hwang WL, Stemmer-Rachamimov AO, Curry WT, Barker FG, Martuza RL, Oh KS, Loeffler JS, Shih HA
Histopathological prognostic factors of recurrence following definitive therapy for atypical and malignant meningiomas.
J Neurosurg. 2017;128(4):1123-1132 - PMID: 28621619 - DOI: 10.3171/2016.11.JNS16913
Hwang KL, Hwang WL, Bussière MR, Shih HA
The role of radiotherapy in the management of high-grade meningiomas.
Chin Clin Oncol. 2017;6(Suppl 1):S5 - PMID: 28758409 - DOI: 10.21037/cco.2017.06.09
Harada BT, Hwang WL, Deindl S, Chatterjee N, Bartholomew B, Zhuang X
Stepwise nucleosome translocation by RSC remodeling complexes.
eLife. 2016;5:ePub - PMID: 26895087 - PMCID: PMC4769157 - DOI: 10.7554/eLife.10051
Hwang WL, Hwang KL, Miyamoto DT
The promise of circulating tumor cells for precision cancer therapy.
Biomark Med. 2016;10(12):1269-1285 - PMID: 27924634 - PMCID: PMC5827810 - DOI: 10.2217/bmm-2016-0192
Hwang WL, Marciscano AE, Niemierko A, Kim DW, Stemmer-Rachamimov AO, Curry WT, Barker FG, Martuza RL, Loeffler JS, Oh KS, Shih HA, Larvie M
Imaging and extent of surgical resection predict risk of meningioma recurrence better than WHO histopathological grade.
Neuro Oncol. 2015;18(6):863-72 - PMID: 26597949 - PMCID: PMC4864259 - DOI: 10.1093/neuonc/nov285
Hwang WL, Deindl S, Harada BT, Zhuang X
Histone H4 tail mediates allosteric regulation of nucleosome remodelling by linker DNA.
Nature. 2014;512(7513):213-7 - PMID: 25043036 - PMCID: PMC4134374 - DOI: 10.1038/nature13380
Deindl S, Hwang WL, Hota SK, Blosser TR, Prasad P, Bartholomew B, Zhuang X
ISWI remodelers slide nucleosomes with coordinated multi-base-pair entry steps and single-base-pair exit steps.
Cell. 2013;152(3):442-52 - PMID: 23374341 - PMCID: PMC3647478 - DOI: 10.1016/j.cell.2012.12.040
Maglia G, Heron AJ, Hwang WL, Holden MA, Mikhailova E, Li Q, Cheley S, Bayley H
Droplet networks with incorporated protein diodes show collective properties.
Nat Nanotechnol. 2009;4(7):437-40 - PMID: 19581896 - DOI: 10.1038/nnano.2009.121
Hwang WL, Chen M, Cronin B, Holden MA, Bayley H
Asymmetric droplet interface bilayers.
J Am Chem Soc. 2008;130(18):5878-9 - PMID: 18407631 - DOI: 10.1021/ja802089s
Syeda R, Holden MA, Hwang WL, Bayley H
Screening blockers against a potassium channel with a droplet interface bilayer array.
J Am Chem Soc. 2008;130(46):15543-8 - PMID: 18950170 - DOI: 10.1021/ja804968g
Hwang WL, Holden MA, White S, Bayley H
Electrical behavior of droplet interface bilayer networks: experimental analysis and modeling.
J Am Chem Soc. 2007;129(38):11854-64 - PMID: 17764183 - DOI: 10.1021/ja074071a
Xu T, Hwang WL, Su F, Chakrabarty K.
Automated design of pin-constrained digital microfluidic biochips under droplet-interference constraints
Journal on Emerging Technologies in Computing. 2007;3(3):14
Su F, Hwang WL, Mukherjee A, Chakrabarty K
Testing and diagnosis of realistic defects in digital microfluidic biochips
Journal of Electronic Testing. 2007;23(2-3):219-33
Curry A, Hwang WL, Wax A
Epi-illumination through the microscope objective applied to darkfield imaging and microspectroscopy of nanoparticle interaction with cells in culture.
Opt Express. 2006;14(14):6535-42 - PMID: 19516830 - DOI: 10.1364/oe.14.006535
Szu H, Hwang WL
Self-supervised backpropagation in stem cells
IEEE Connections. 2003;1(3):8-9
51 CSV