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Micro-Nuclear Magnetic Resonance based detection of circulating tumor cells directly in whole blood

Cesar M. Castro, MD; Hakho Lee, PhD; Ralph Weissleder, MD, PhD

The overall goal of this project is to optimize and leverage magnetic resonance based nanotechnologies and bio-orthogonal chemistries to detect circulating tumor cells directly in whole blood.

Status: Open for enrollment
Type of trial: Translational
Collaborators: Michael J. Birrer, MD, PhD
Funding: Department of Defense
Publications: Submitted

Development of a rapid Diagnostic Magnetic Resonance assay to assess response to an irreversible pan-HER tyrosine kinase inhibitor in adult glioblastoma multiforme patients with EGFR amplification

Cesar M. Castro, MD; Hakho Lee, PhD; Ralph Weissleder, MD, PhD

To determine whether the level or activation status of EGFR pathway proteins detected by a novel DMR based assay can predict response and/or detect progression during treatment with a novel irreversible pan-HER tyrosine kinase inhibitor.

Status: Open for enrollment
Type of trial: Clinical Trial; Intervention
Collaborators: Andrew Chi, MD, PhD; Tracy Batchelor, MD; Xandra Breakefield, PhD
Funding: Ivy Foundation
Publications: Ongoing Trial

Customizing a micro-Nuclear Magnetic Resonance assay to specifically detect and profile cancer cells in ascites from women with ovarian cancer
Cesar M. Castro, MD; Hakho Lee, PhD; Ralph Weissleder, MD, PhD

To develop an assay to rapidly detect and profile a rationally derived panel of ovarian cancer proteins in ascites from women with ovarian cancer. To determine whether protein profiles correlate with clinical outcomes.

Status: Open for enrollment
Type of trial: Clinical Trial; Translational
Collaborators: Michael J. Birrer, MD, PhD; Richard Penson, MD; Carolyn Krasner, MD
Funding: Department of Defense
Publications: Ongoing Trial

Clinical Trials in planning

Comparative analyses of circulating tumor cells with primary tumors using magnetic resonance

Cesar M. Castro, MD; Hakho Lee, PhD; Ralph Weissleder, MD, PhD

Usine micro-Nuclear Magnetic Resonance to molecularly characterize and compare circulating tumor cells and primary tumors. To ascertain whether changes in number and molecular profile of circulating tumor cells occur over a course of chemotherapy.

Status: Under IRB review
Type of Trial: Clinical trial; Imaging; Translational
Funding: National Institutes of Health
Publications: n/a

Clinical Trials Completed

Micro-NMR for Rapid Molecular Analyses of Human Tumor Samples

To rapidly detect and profile cancer-related proteins in fine needle aspirates derived from patients with solid epithelial tumors.

Cesar M. Castro, MD; Hakho Lee, PhD; Ralph Weissleder, MD, PhD

Status: Completed
Type of trial: Translational
Funding: National Institutes of Health
Publications: Science Translational Medicine 2011 Feb 23; 3(71):71ra16

Revised on 2012-01-27 20:26:37 UTC