Alt, Clemens, PhD

Instructor

Phone: 617-643-3531
Email: alt@helix.mgh.harvard.edu
Lab: Lin, Charles

Publications

  • Pessoa Rodrigues C, Collins JM, Yang S, Martinez C, Kim JW, Lama C, Nam AS, Alt C, Lin C, Zon LI Transcripts of repetitive DNA elements signal to block phagocytosis of hematopoietic stem cells. Science. 2024;385(6714):eadn1629 - PMID: 39264994 - DOI: 10.1126/science.adn1629

  • Wu Q, Zhang J, Kumar S, Shen S, Kincaid M, Johnson CB, Zhang YS, Turcotte R, Alt C, Ito K, Homan S, Sherman BE, Shao TY, Slaughter A, Weinhaus B, Song B, Filippi MD, Grimes HL, Lin CP, Ito K, Way SS, Kofron JM, Lucas D Resilient anatomy and local plasticity of naive and stress haematopoiesis. Nature. 2024;627(8005):839-846 - PMID: 38509363 - PMCID: PMC10972750 - DOI: 10.1038/s41586-024-07186-6

  • Conedera FM, Kokona D, Zinkernagel MS, Stein JV, Lin CP, Alt C, Enzmann V Macrophages coordinate immune response to laser-induced injury via extracellular traps. J Neuroinflammation. 2024;21(1):68 - PMID: 38500151 - PMCID: PMC10949579 - DOI: 10.1186/s12974-024-03064-0

  • Conedera FM, Runnels JM, Stein JV, Alt C*, Enzmann V*, Lin CP* Assessing the role of T cells in response to retinal injury to uncover new therapeutic targets for the treatment of retinal degeneration. J Neuroinflammation. 2023;20(1):206 - PMID: 37689689 - PMCID: PMC10492418 - DOI: 10.1186/s12974-023-02867-x

  • Jiménez-Dinamarca I, Prado Y, Tapia P, Gatica S, Alt C, Lin CP, Reyes-Martínez C, Feijóo CG, Aravena C, González-Canacer A, Correa S, Varela D, Cabello-Verrugio C, Simon F Correction: Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis. Biol Res. 2023;56(1):24 - PMID: 37165417 - PMCID: PMC10173557 - DOI: 10.1186/s40659-023-00433-6

  • Jiménez-Dinamarca I, Prado Y, Tapia P, Gatica S, Alt C, Lin CP, Reyes-Martínez C, Feijóo CG, Aravena C, González-Canacer A, Correa S, Varela D, Cabello-Verrugio C, Simon F Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis. Biol Res. 2023;56(1):8 - PMID: 36869357 - PMCID: PMC9983216 - DOI: 10.1186/s40659-023-00419-4

  • Snyder PJ, Alber J, Alt C, Bain LJ, Bouma BE, Bouwman FH, DeBuc DC, Campbell MCW, Carrillo MC, Chew EY, Cordeiro MF, Dueñas MR, Fernández BM, Koronyo-Hamaoui M, La Morgia C, Carare RO, Sadda SR, van Wijngaarden P, Snyder HM Retinal imaging in Alzheimer's and neurodegenerative diseases. Alzheimers Dement. 2020;17(1):103-111 - PMID: 33090722 - PMCID: PMC8062064 - DOI: 10.1002/alz.12179

  • Paudel HP, Alt C, Runnels J, Lin CP Pupil plane differential detection microscopy. Opt Lett. 2018;43(18):4410-4412 - PMID: 30211877 - PMCID: PMC6492546 - DOI: 10.1364/OL.43.004410

  • Soeken TA, Zhu H, DeMartelaere S, Davies BW, Kim M, Wang HC, Aden J, Grimm R, Alt C, Kochevar IE, Johnson AJ Sealing of Corneal Lacerations Using Photoactivated Rose Bengal Dye and Amniotic Membrane. Cornea. 2018;37(2):211-217 - PMID: 29140861 - DOI: 10.1097/ICO.0000000000001389

  • Tokarz D, Cisek R, Wein MN, Turcotte R, Haase C, Yeh SA, Bharadwaj S, Raphael AP, Paudel H, Alt C, Liu TM, Kronenberg HM, Lin CP Intravital imaging of osteocytes in mouse calvaria using third harmonic generation microscopy. PLoS ONE. 2017;12(10):e0186846 - PMID: 29065178 - PMCID: PMC5655444 - DOI: 10.1371/journal.pone.0186846

  • Turcotte R, Alt C, Runnels JM, Ito K, Wu JW, Zaher W, Mortensen LJ, Silberstein L, Côté DC, Kung AL, Ito K, Lin CP Image-guided transplantation of single cells in the bone marrow of live animals. Sci Rep. 2017;7(1):3875 - PMID: 28634334 - PMCID: PMC5478633 - DOI: 10.1038/s41598-017-02896-6

  • Li YX, Gautam V, Brüstle A, Cockburn IA, Daria VR, Gillespie C, Gaus K, Alt C, Lee WM Flexible polygon-mirror based laser scanning microscope platform for multiphoton in-vivo imaging. J Biophotonics. 2017;10(11):1526-1537 - PMID: 28164461 - DOI: 10.1002/jbio.201600289

  • Ito K, Turcotte R, Cui J, Zimmerman SE, Pinho S, Mizoguchi T, Arai F, Runnels JM, Alt C, Teruya-Feldstein J, Mar JC, Singh R, Suda T, Lin CP, Frenette PS, Ito K Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance. Science. 2016;354(6316):1156-1160 - PMID: 27738012 - PMCID: PMC5164878 - DOI: 10.1126/science.aaf5530

  • Zhu H, Alt C, Webb RH, Melki S, Kochevar IE Corneal Crosslinking With Rose Bengal and Green Light: Efficacy and Safety Evaluation. Cornea. 2016;35(9):1234-41 - PMID: 27362877 - DOI: 10.1097/ICO.0000000000000916

  • Wu JW, Turcotte R, Alt C, Runnels JM, Tsao H, Lin CP Defining Clonal Color in Fluorescent Multi-Clonal Tracking. Sci Rep. 2016;6:24303 - PMID: 27073117 - PMCID: PMC4829845 - DOI: 10.1038/srep24303

  • Framme C, Walter A, Berger L, Prahs P, Alt C, Theisen-Kunde D, Kowal J, Brinkmann R Selective Retina Therapy in Acute and Chronic-Recurrent Central Serous Chorioretinopathy. Ophthalmologica. 2015;234(4):177-188 - PMID: 26368551 - DOI: 10.1159/000439188

  • Mortensen LJ, Alt C, Turcotte R, Masek M, Liu TM, Côté DC, Xu C, Intini G, Lin CP Femtosecond laser bone ablation with a high repetition rate fiber laser source. Biomed Opt Express. 2014;6(1):32-42 - PMID: 25657872 - PMCID: PMC4317121 - DOI: 10.1364/BOE.6.000032

  • Turcotte R, Alt C, Mortensen LJ, Lin CP Characterization of multiphoton microscopy in the bone marrow following intravital laser osteotomy. Biomed Opt Express. 2014;5(10):3578-88 - PMID: 25360374 - PMCID: PMC4206326 - DOI: 10.1364/BOE.5.003578

  • Alt C, Runnels JM, Mortensen LJ, Zaher W, Lin C In vivo imaging of microglia turnover in the mouse retina after ionizing radiation and dexamethasone treatment. Invest Ophthalmol Vis Sci. 2014;55(8):5314-5319 - PMID: 25082884 - DOI: 10.1167/iovs.14-14254

  • Ksander BR, Kolovou PE, Wilson BJ, Saab KR, Guo Q, Ma J, McGuire SP, Gregory MS, Vincent WJ, Perez VL, Cruz-Guilloty F, Kao WW, Call MK, Tucker BA, Zhan Q, Murphy GF, Lathrop KL, Alt C, Mortensen LJ, Lin CP, Zieske JD, Frank MH, Frank NY ABCB5 is a limbal stem cell gene required for corneal development and repair. Nature. 2014;511(7509):353-7 - PMID: 25030174 - PMCID: PMC4246512 - DOI: 10.1038/nature13426

  • Spencer JA, Ferraro F, Roussakis E, Klein A, Wu J, Runnels JM, Zaher W, Mortensen LJ, Alt C, Turcotte R, Yusuf R, Côté D, Vinogradov SA, Scadden DT, Lin CP Direct measurement of local oxygen concentration in the bone marrow of live animals. Nature. 2014;508(7495):269-73 - PMID: 24590072 - PMCID: PMC3984353 - DOI: 10.1038/nature13034

  • Buys ES, Ko YC, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clerte' M, Abernathy E, Tainsh RE, Oh DJ, Malhotra R, Arora P, de Waard N, Yu B, Turcotte R, Nathan D, Scherrer-Crosbie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR Soluble Guanylate Cyclase a1-Deficient Mice: a novel murine model for Primary Open Angle Glaucoma. 2013;20(2):65-6 - PMID: 25206015 - PMCID: PMC4117107 - DOI: 10.5214/ans.0972.7531.200207

  • Buys ES, Ko YC, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clerté M, Abernathy E, Tainsh RE, Oh DJ, Malhotra R, Arora P, de Waard N, Yu B, Turcotte R, Nathan D, Scherrer-Crosbie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR Soluble Guanylate Cyclase α1-Deficient Mice: A Novel Murine Model for Primary Open Angle Glaucoma. PLoS ONE. 2013;8(3):e60156 - PMID: 23527308 - PMCID: PMC3603933 - DOI: 10.1371/journal.pone.0060156

  • Zhang L, Alt C, Li P, White RM, Zon LI, Wei X, Lin CP An optical platform for cell tracking in adult zebrafish. Cytometry A. 2011;81(2):176-82 - PMID: 22162445 - PMCID: PMC6383206 - DOI: 10.1002/cyto.a.21167

  • Azab A, Runnels J, Pitsillides C, Moreau A, Azab F, Leleu X, Jia X, Wright R, Ospina B, Carlson A, Alt C, Burwick N, Roccaro A, Ngo H, Farag M, Melhem M, Sacco A, Munshi N, Hideshima T, Rollins B, Anderson K, Kung A, Lin CP, Ghobrial I CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy. Blood. 2009;113:4341-51 - PMID: 19139079 - PMCID: PMC2676090 - DOI: 10.1182/blood-2008-10-186668

  • Framme C, Alt C, Schnell S, Sherwood M, Brinkmann R, Lin CP Selective targeting of the retinal pigment epithelium in rabbit eyes with a scanning laser beam. Invest Ophth Vis Sci. 2007;48:1782-92 - PMID: 17389512 - DOI: 10.1167/iovs.06-0797

  • Lee H, Alt C, Pitsillides C, Lin CP Optical detection of intracellular cavitation during selective laser targeting of the retinal pigment epithelium: dependence of cell death mechanism on pulse duration. J Biomed Opt. 2007;12:064034 - PMID: 18163850 - DOI: 10.1117/1.2804078

  • Alt C, Veilleux I, Lee H, Pitsillides CM, Cote D, Lin CP Retinal flow cytometer. Opt Lett. 2007;32:3450-2 - PMID: 18059963 - PMCID: PMC2794483 - DOI: 10.1364/ol.32.003450

  • Alt C, Framme C, Schnell S, Lee H, Brinkmann R, Lin CP Selective targeting of the retinal pigment epithelium using an acousto-optic laser scanner. J Biomed Opt. 2006;10(6):064014 - PMID: 16409079 - DOI: 10.1117/1.2136314

  • Lee H, Alt C, Pitsillides CM, Puoris'haag M, Lin CP In vivo imaging flow cytometer. Opt Express. 2006;14:7789-800 - PMID: 19529148 - PMCID: PMC2801598 - DOI: 10.1364/oe.14.007789

  • Framme C, Alt C, Schnell S, Brinkmann R, Lin CP [Selective RPE laser treatment with a scanned cw laser beam in rabbits]. Ophthalmologie. 2005;102(5):491-6 - PMID: 15883846 - DOI: 10.1007/s00347-004-1139-5

  • Brinkmann R, Koop N, Ozdemir M, Alt C, Sch Targeting of the retinal pigment epithelium (RPE) by means of a rapidly scanned continuous wave (CW) laser beam. Laser Surg Med. 2003;32:252-64 - PMID: 12696092 - DOI: 10.1002/lsm.10150