Investigator

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About

Alt, Clemens, PhD

Clemens_alt
Phone: 617-643-3531
Email: alt@helix.mgh.harvard.edu
Lab: Lin, Charles

Publications

Turcotte R, Alt C, Runnels JM, Ito K, Wu JW, Zaher W, Mortensen LJ, Silberstein L, Côté DC, Kung AL, Ito K, Lin CP
Image-guided transplantation of single cells in the bone marrow of live animals.
Sci Rep. 2017;7(1):3875 - PMID: 28634334 - PMCID: PMC5478633
Li YX, Gautam V, Brüstle A, Cockburn IA, Daria VR, Gillespie C, Gaus K, Alt C, Lee WM
Flexible polygon-mirror based laser scanning microscope platform for multiphoton in-vivo imaging.
J Biophotonics. 2017;:ePub - PMID: 28164461
Ito K, Turcotte R, Cui J, Zimmerman SE, Pinho S, Mizoguchi T, Arai F, Runnels JM, Alt C, Teruya-Feldstein J, Mar JC, Singh R, Suda T, Lin CP, Frenette PS, Ito K
Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance.
Science. 2016;354(6316):1156-1160 - PMID: 27738012 - PMCID: PMC5164878
Wu JW, Turcotte R, Alt C, Runnels JM, Tsao H, Lin CP
Defining Clonal Color in Fluorescent Multi-Clonal Tracking
Sci Rep. 2016;6:24303 - PMID: 27073117 - PMCID: PMC4829845
Zhu H, Alt C, Webb RH, Melki S, Kochevar IE
Corneal Crosslinking With Rose Bengal and Green Light: Efficacy and Safety Evaluation.
Cornea. 2016;35(9):1234-41 - PMID: 27362877
Framme C, Walter A, Berger L, Prahs P, Alt C, Theisen-Kunde D, Kowal J, Brinkmann R
Selective Retina Therapy in Acute and Chronic-Recurrent Central Serous Chorioretinopathy.
Ophthalmologica. 2015;234(4):177-188 - PMID: 26368551
Ksander BR, Kolovou PE, Wilson BJ, Saab KR, Guo Q, Ma J, McGuire SP, Gregory MS, Vincent WJ, Perez VL, Cruz-Guilloty F, Kao WW, Call MK, Tucker BA, Zhan Q, Murphy GF, Lathrop KL, Alt C, Mortensen LJ, Lin CP, Zieske JD, Frank MH, Frank NY
ABCB5 is a limbal stem cell gene required for corneal development and repair.
Nature. 2014;511(7509):353-7 - PMID: 25030174 - PMCID: PMC4246512
Spencer JA, Ferraro F, Roussakis E, Klein A, Wu J, Runnels JM, Zaher W, Mortensen LJ, Alt C, Turcotte R, Yusuf R, Côté D, Vinogradov SA, Scadden DT, Lin CP
Direct measurement of local oxygen concentration in the bone marrow of live animals.
Nature. 2014;508(7495):269-73 - PMID: 24590072 - PMCID: PMC3984353
Alt C, Runnels JM, Mortensen LJ, Zaher W, Lin C
In vivo imaging of microglia turnover in the mouse retina after ionizing radiation and dexamethasone treatment.
Invest Ophthalmol Vis Sci. 2014;55(8):5314-5319 - PMID: 25082884
Turcotte R, Alt C, Mortensen LJ, Lin CP
Characterization of multiphoton microscopy in the bone marrow following intravital laser osteotomy.
Biomed Opt Express. 2014;5(10):3578-88 - PMID: 25360374 - PMCID: PMC4206326
Mortensen LJ, Alt C, Turcotte R, Masek M, Liu TM, Côté DC, Xu C, Intini G, Lin CP
Femtosecond laser bone ablation with a high repetition rate fiber laser source.
Biomed Opt Express. 2014;6(1):32-42 - PMID: 25657872 - PMCID: PMC4317121
Buys ES, Ko YC, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clerté M, Abernathy E, Tainsh RE, Oh DJ, Malhotra R, Arora P, de Waard N, Yu B, Turcotte R, Nathan D, Scherrer-Crosbie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR
Soluble Guanylate Cyclase α1-Deficient Mice: A Novel Murine Model for Primary Open Angle Glaucoma.
PLoS ONE. 2013;8(3):e60156 - PMID: 23527308 - PMCID: PMC3603933
Buys ES, Ko YC, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clerte' M, Abernathy E, Tainsh RE, Oh DJ, Malhotra R, Arora P, de Waard N, Yu B, Turcotte R, Nathan D, Scherrer-Crosbie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR
Soluble Guanylate Cyclase a1-Deficient Mice: a novel murine model for Primary Open Angle Glaucoma.
2013;20(2):65-6 - PMID: 25206015 - PMCID: PMC4117107
Zhang L, Alt C, Li P, White RM, Zon LI, Wei X, Lin CP
An optical platform for cell tracking in adult zebrafish.
Cytometry A. 2011;81(2):176-82 - PMID: 22162445
Azab A, Runnels J, Pitsillides C, Moreau A, Azab F, Leleu X, Jia X, Wright R, Ospina B, Carlson A, Alt C, Burwick N, Roccaro A, Ngo H, Farag M, Melhem M, Sacco A, Munshi N, Hideshima T, Rollins B, Anderson K, Kung A, Lin CP, Ghobrial I
CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.
Blood. 2009;113:4341-51 - PMID: 19139079 - PMCID: PMC2676090
Framme C, Alt C, Schnell S, Sherwood M, Brinkmann R, Lin CP
Selective targeting of the retinal pigment epithelium in rabbit eyes with a scanning laser beam.
Invest Ophth Vis Sci. 2007;48:1782-92 - PMID: 17389512
Alt C, Veilleux I, Lee H, Pitsillides CM, Cote D, Lin CP
Retinal flow cytometer.
Opt Lett. 2007;32:3450-2 - PMID: 18059963 - PMCID: PMC2794483
Lee H, Alt C, Pitsillides C, Lin CP
Optical detection of intracellular cavitation during selective laser targeting of the retinal pigment epithelium: dependence of cell death mechanism on pulse duration.
J Biomed Opt. 2007;12:064034 - PMID: 18163850
Lee H, Alt C, Pitsillides CM, Puoris'haag M, Lin CP
In vivo imaging flow cytometer.
Opt Express. 2006;14:7789-800 - PMID: 19529148 - PMCID: PMC2801598
Alt C, Framme C, Schnell S, Lee H, Brinkmann R, Lin CP
Selective targeting of the retinal pigment epithelium using an acousto-optic laser scanner.
J Biomed Opt. 2006;10(6):064014 - PMID: 16409079
Framme C, Alt C, Schnell S, Brinkmann R, Lin CP
[Selective RPE laser treatment with a scanned cw laser beam in rabbits]
Ophthalmologie. 2005;102(5):491-6 - PMID: 15883846
Brinkmann R, Koop N, Ozdemir M, Alt C, Sch
Targeting of the retinal pigment epithelium (RPE) by means of a rapidly scanned continuous wave (CW) laser beam.
Laser Surg Med. 2003;32:252-64 - PMID: 12696092
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