Cardiovascular

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Cardiovascular Program

Cardiovascular_program

Funding

  • NHLBI
  • NIAID

The Cardiovascular and Metabolic Program aims at advancing the knowledge of prevalent cardiovascular and metabolic diseases and accelerating the development of new therapeutic and diagnostic strategies. The program brings together scientists from multiple communities within MGH and Harvard. Collectively, the projects described below undertake a variety of systems-level analyses, including systematic mapping of genetic/functional interactions, functional genomics, and in vivo molecular imaging.

Atherosclerosis/Myocardial infarction

  • Exploring the role of inflammatory networks in ischemic heart disease and stroke
  • Major focus on monocyte/macrophage subsets, their function and ontogeny
  • Chemical biology and genomic studies to assign function to susceptibility alleles for atherosclerosis or myocardial infarction
  • Nanomaterial-based molecular imaging probes to define cellular and enzymatic components of plaque, and monitor disease progression and therapeutic response in pre-clinical studies and clinical trials

Metabolism and energetics

  • Systematic mapping of metabolic pathways in health and disease using mass spectrometry-based metabolomics and proteomics
  • Translational research in metabolic syndrome
  • Functional genomics of mitochondrial function in diabetes and other human diseases

Stem cells and regeneration

  • Role of hematopoietic stem cells in ischemic heart disease and stroke
  • Small molecule approaches to direct differentiation of stem cells into the cardiac lineage
  • Chemical screens in stem cells or model organisms to dissect developmental pathways and manipulate them for therapeutic benefit
  • Nanoparticle-based imaging of transplanted stem cells in vivo

Novel biomarkers for diagnosis, clinical phenotyping and disease status

  • Metabolites
  • Cell-based phenotypes
  • Nanoparticle-based molecular imaging
  • Benchtop parallel measurement of multiplexed analytes

Recent Publications (more...)

Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, Kim HY, Wang C, Chen JW, Swirski FK, Wey HY, Hooker J, Fayad ZA, Mulder WJ, Weissleder R, Nahrendorf M
Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease.
Nat Commun. 2017;8:14064 - PMID: 28091604 - PMCID: PMC5241815
Frodermann V, Nahrendorf M
Neutrophil-macrophage cross-talk in acute myocardial infarction.
Eur Heart J. 2017;38(3):198-200 - PMID: 28158564
Tang J, Baxter S, Menon A, Alaarg A, Sanchez-Gaytan BL, Fay F, Zhao Y, Ouimet M, Braza MS, Longo VA, Abdel-Atti D, Duivenvoorden R, Calcagno C, Storm G, Tsimikas S, Moore KJ, Swirski FK, Nahrendorf M, Fisher EA, Pérez-Medina C, Fayad ZA, Reiner T, Mulder WJ
Immune cell screening of a nanoparticle library improves atherosclerosis therapy.
Proc Natl Acad Sci U S A. 2016;113(44):E6731-E6740 - PMID: 27791119 - PMCID: PMC5098679
Fenn AM, Swirski FK
Monocytosis, Hypercholesterolemia, and the Kinase That Binds Them.
Arterioscler Thromb Vasc Biol. 2017;37(2):173-175 - PMID: 28122772

Recent News (more...)

2016-12-07: Anwesha Chaudhury (Higgins Lab) has been awarded a Research Fellowship from the Life Sciences Research Foundation for her project “Mathematical modeling of white blood cell population dynamics for disease prognosis.” According to the foundation, “Every year our selection committee of renowned scientists identify the top 5% of applicants from an international pool of more than 1000 postdoctoral applicants.”
2016-09-16: Circulation Research spotlights a profile of Matthias Nahrendorf, MD PhD and his research. (pdf)
2016-08-15: Matthias Nahrendorf, MD, PhD was appointed International Associate Editor for the European Heart Journal.
2016-07-14: CSB work is highlighted in Nature Reviews Cardiology. (pdf)
2015-09-24: Dong-Eog Kim (Dongguk University, Seoul) and Matthias Nahrendorf received the “Global Research Lab” award from the Korean government, an initiative that integrates US and Korean scientists.