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Schloss MJ, Hulsmans M, Rohde D, Lee IH, Severe N, Foy BH, Pulous FE, Zhang S, Kokkaliaris KD, Frodermann V, Courties G, Yang C, Iwamoto Y, Knudsen AS, McAlpine CS, Yamazoe M, Schmidt SP, Wojtkiewicz GR, Masson GS, Gustafsson K, Capen D, Brown D, Higgins JM, Scadden DT, Libby P, Swirski FK, Naxerova K, Nahrendorf M
B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis.
Nat Immunol. 2022;23(4):605-618 - PMID: 35352063 - PMCID: PMC8989652 - DOI: 10.1038/s41590-022-01165-7
Grune J, Lewis AJM, Yamazoe M, Hulsmans M, Rohde D, Xiao L, Zhang S, Ott C, Calcagno DM, Zhou Y, Timm K, Shanmuganathan M, Pulous FE, Schloss MJ, Foy BH, Capen D, Vinegoni C, Wojtkiewicz GR, Iwamoto I, Grune T, Brown D, Higgins J, Ferreira VM, Herring N, Channon KM, Neubauer S, Oxford Acute Myocardial Infarction (OxAMI) Study, Sosnovik DE, Milan DJ, Swirski FK, King KR, Aguirre AD, Ellinor PT, Nahrendorf M
Neutrophils incite and macrophages avert electrical storm after myocardial infarction
Nat Cardiovasc Res. 2022;1(7):649-664 - PMID: 36034743 - PMCID: PMC9410341 - DOI: 10.1038/s44161-022-00094-w
Zaidman NA, Tomilin VN, Hassanzadeh Khayyat N, Damarla M, Tidmore J, Capen DE, Brown D, Pochynyuk OM, Pluznick JL
Adhesion-GPCR Gpr116 (ADGRF5) expression inhibits renal acid secretion.
Proc Natl Acad Sci U S A. 2020;117(42):26470-26481 - PMID: 33004624 - PMCID: PMC7584995 - DOI: 10.1073/pnas.2007620117
Battistone MA, Mendelsohn AC, Spallanzani RG, Allegretti AS, Liberman RN, Sesma J, Kalim S, Wall SM, Bonventre JV, Lazarowski ER, Brown D, Breton S
Pro-inflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice.
J Clin Invest. 2020;130(7):3734-3749 - PMID: 32287042 - PMCID: PMC7324186 - DOI: 10.1172/JCI134791
Brown CR, Gupta S, Qin J, Racie T, He G, Lentini S, Malone R, Yu M, Matsuda S, Shulga-Morskaya S, Nair AV, Theile CS, Schmidt K, Shahraz A, Goel V, Parmar RG, Zlatev I, Schlegel MK, Nair JK, Jayaraman M, Manoharan M, Brown D, Maier MA, Jadhav V
Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates.
Nucleic Acids Res. 2020;48(21):11827-11844 - PMID: 32808038 - PMCID: PMC7708070 - DOI: 10.1093/nar/gkaa670
Bouley R, Yui N, Terlouw A, Cheung PW, Brown D
Chlorpromazine Induces Basolateral Aquaporin-2 Accumulation via F-Actin Depolymerization and Blockade of Endocytosis in Renal Epithelial Cells.
Cells. 2020;9(4):ePub - PMID: 32340337 - PMCID: PMC7226349 - DOI: 10.3390/cells9041057
Mendelsohn AC, Sanmarco LM, Spallanzani RG, Brown D, Quintana FJ, Breton S, Battistone MA
From initial segment to cauda: A regional characterization of mouse epididymal CD11c+ mononuclear phagocytes based on immune phenotype and function.
2020;319(6):C997-C1010 - PMID: 32991210 - PMCID: PMC7792679 - DOI: 10.1152/ajpcell.00392.2020
Hoyer FF*, Naxerova K*, Schloss MJ, Hulsmans M, Nair AV, Dutta P, Calcagno DM, Herisson F, Anzai A, Sun Y, Wojtkiewicz G, Rohde D, Frodermann V, Vandoorne K, Courties G, Iwamoto Y, Garris CS, Williams DL, Breton S, Brown D, Whalen M, Libby P, Pittet MJ, King KR, Weissleder R, Swirski FK, Nahrendorf M
Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge.
Immunity. 2019;51(5):899-914.e7 - PMID: 31732166 - PMCID: PMC6892583 - DOI: 10.1016/j.immuni.2019.10.010
Cheung PW, Bouley R, Brown D
Targeting the Trafficking of Kidney Water Channels for Therapeutic Benefit.
Annu Rev Pharmacol Toxicol. 2019;60:175-194 - PMID: 31561739 - PMCID: PMC7334826 - DOI: 10.1146/annurev-pharmtox-010919-023654
Ferder IC, Fung L, Ohguchi Y, Zhang X, Lassen KG, Capen D, Brown D, Xavier RJ, Wang N
Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice.
PLoS Genet. 2019;15(5):e1008084 - PMID: 31059511 - PMCID: PMC6502318 - DOI: 10.1371/journal.pgen.1008084
Battistone MA, Spallanzani RG, Mendelsohn AC, Capen D, Nair AV, Brown D, Breton S
Novel role of proton-secreting epithelial cells in sperm maturation and mucosal immunity.
J Cell Sci. 2019;133(5):ePub - PMID: 31636115 - PMCID: PMC7003979 - DOI: 10.1242/jcs.233239
Battistone MA, Merkulova M, Park YJ, Peralta MA, Gombar F, Brown D, Breton S
Unraveling purinergic regulation in the epididymis: Activation of V-ATPase-dependent acidification by luminal ATP and adenosine.
J Physiol. 2019;597(7):1957-1973 - PMID: 30746715 - PMCID: PMC6441927 - DOI: 10.1113/JP277565
Nair AV, Yanhong W, Paunescu TG, Bouley R, Brown D
Sex-dependent differences in water homeostasis in wild-type and V-ATPase B1-subunit deficient mice.
PLoS ONE. 2019;14(8):e0219940 - PMID: 31386675 - PMCID: PMC6684071 - DOI: 10.1371/journal.pone.0219940
Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, Păunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA
Reply to Edemir: Physiological regulation and single-cell RNA sequencing.
Proc Natl Acad Sci U S A. 2018;115(3):E351-E352 - PMID: 29311339 - PMCID: PMC5777009 - DOI: 10.1073/pnas.1720333115
Sands JM, Hay M, Brown D
APS: Moving Forward to Aid Our Membership.
Physiology (Bethesda). 2018;33(6):370-371 - PMID: 30303777 - DOI: 10.1152/physiol.00039.2018
Cheung PW, Terlouw A, Janssen SA, Brown D, Bouley R
Inhibition of non-receptor tyrosine kinase Src induces phosphoserine 256-independent aquaporin-2 membrane accumulation.
J Physiol. 2018;597(6):1627-1642 - PMID: 30488437 - PMCID: PMC6418769 - DOI: 10.1113/JP277024
Breton S, Brown D
Novel Proinflammatory Function of Renal Intercalated Cells.
Ann Nutr Metab. 2018;72 Suppl 2:11-16 - PMID: 29925073 - DOI: 10.1159/000488303
Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M
Macrophages Facilitate Electrical Conduction in the Heart
Cell. 2017;169:510-522 - PMID: 28431249 - PMCID: PMC5474950 - DOI: 10.1016/j.cell.2017.03.050
Behzadi S, Serpooshan V, Tao W, Hamaly MA, Alkawareek MY, Dreaden EC, Brown D, Alkilany AM, Farokhzad OC, Mahmoudi M
Cellular uptake of nanoparticles: journey inside the cell.
Chem Soc Rev. 2017;46(14):4218-4244 - PMID: 28585944 - PMCID: PMC5593313 - DOI: 10.1039/c6cs00636a
Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, Păunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA
Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq.
Proc Natl Acad Sci U S A. 2017;114(46):E9989-E9998 - PMID: 29089413 - PMCID: PMC5699061 - DOI: 10.1073/pnas.1710964114
Nigwekar SU, Weiser JM, Kalim S, Xu D, Wibecan JL, Dougherty SM, Mercier-Lafond L, Corapi KM, Eneanya ND, Holbrook EH, Brown D, Thadhani RI, Păunescu TG
Characterization and Correction of Olfactory Deficits in Kidney Disease.
J Am Soc Nephrol. 2017;28(11):3395-3403 - PMID: 28775001 - PMCID: PMC5661283 - DOI: 10.1681/ASN.2016121308
Bourgeois S, Bounoure L, Mouro-Chanteloup I, Colin Y, Brown D, Wagner CA
The ammonia transporter RhCG modulates urinary acidification by interacting with the vacuolar proton-ATPases in renal intercalated cells.
Kidney Int. 2017;93(2):390-402 - PMID: 29054531 - PMCID: PMC6166241 - DOI: 10.1016/j.kint.2017.07.027
Brown D, Sands JM, Reckelhoff JF
APS: The Times They Are A-Changin'.
Physiology (Bethesda). 2017;32(6):400-401 - PMID: 28978629 - DOI: 10.1152/physiol.00025.2017
Li W, Jin WW, Tsuji K, Chen Y, Nomura N, Su L, Yui N, Arthur J, Cotecchia S, Păunescu TG, Brown D, Lu HAJ
Direct interaction of ezrin and AQP2 and its role in AQP2 trafficking.
J Cell Sci. 2017;130(17):2914-2925 - PMID: 28754689 - PMCID: PMC5612225 - DOI: 10.1242/jcs.204842
Cheung PW, Ueberdiek L, Day J, Bouley R, Brown D
Protein phosphatase 2C (PP2C) is responsible for VP-induced dephosphorylation of AQP2 serine 261.
Am J Physiol Renal Physiol. 2017;313(2):F404-F413 - PMID: 28381458 - PMCID: PMC5582913 - DOI: 10.1152/ajprenal.00004.2017
Brown D
The Discovery of Water Channels (Aquaporins).
Ann Nutr Metab. 2017;70 Suppl 1:37-42 - PMID: 28614812 - DOI: 10.1159/000463061
Christensen HL, Păunescu TG, Matchkov V, Barbuskaite D, Brown D, Damkier HH, Praetorius J
The V-ATPase is expressed in the choroid plexus and mediates cAMP-induced intracellular pH alterations.
Physiol Rep. 2017;5(1):ePub - PMID: 28053225 - PMCID: PMC5256157 - DOI: 10.14814/phy2.13072
Roy J*, Kim B*, Hill E, Visconti P, Krapf D, Vinegoni C, Weissleder R, Brown D, Breton S
Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging.
Nat Commun. 2016;7:10666 - PMID: 26868824 - PMCID: PMC4754344 - DOI: 10.1038/ncomms10666
Chen YC, Backus KM, Merkulova M, Yang C, Brown D, Cravatt BF, Zhang C
Covalent Modulators of the Vacuolar ATPase.
J Am Chem Soc. 2016;139(2):639-642 - PMID: 28010062 - PMCID: PMC5274637 - DOI: 10.1021/jacs.6b12511
Mumtaz R, Trepiccione F, Hennings JC, Huebner AK, Serbin B, Picard N, Ullah AK, Păunescu TG, Capen DE, Lashhab RM, Mouro-Chanteloup I, Alper SL, Wagner CA, Cordat E, Brown D, Eladari D, Hübner CA
Intercalated Cell Depletion and Vacuolar H+-ATPase Mistargeting in an AE1 R607H Knockin Model.
J Am Soc Nephrol. 2016;28(5):1507-1520 - PMID: 27932475 - PMCID: PMC5407715 - DOI: 10.1681/ASN.2016020169
Cheung PW, Nomura N, Nair AV, Pathomthongtaweechai N, Ueberdiek L, Lu HA, Brown D, Bouley R
EGF Receptor Inhibition by Erlotinib Increases Aquaporin 2-Mediated Renal Water Reabsorption.
J Am Soc Nephrol. 2016;27(10):3105-3116 - PMID: 27694161 - PMCID: PMC5042667 - DOI: 10.1681/ASN.2015080903
Trepiccione F, Gerber SD, Grahammer F, López-Cayuqueo KI, Baudrie V, Păunescu TG, Capen DE, Picard N, Alexander RT, Huber TB, Chambrey R, Brown D, Houillier P, Eladari D, Simons M
Renal Atp6ap2/(Pro)renin Receptor Is Required for Normal Vacuolar H+-ATPase Function but Not for the Renin-Angiotensin System.
J Am Soc Nephrol. 2016;27(11):3320-3330 - PMID: 27044666 - PMCID: PMC5084887 - DOI: 10.1681/ASN.2015080915
Cheung PW, Nomura N, Nair AV, Pathomthongtaweechai N, Ueberdiek L, Jenny Lu HA, Brown D, Bouley R
EGF Receptor Inhibition by Erlotinib Increases Aquaporin 2-Mediated Renal Water Reabsorption.
J Am Soc Nephrol. 2016;:ePub - PMID: 26961350 - DOI: 10.1681/ASN.2015080903
Reckelhoff JF, Brown D, Molina PE
APS Takes a Look in the Mirror.
Physiology (Bethesda). 2016;31(6):384-385 - PMID: 27708041 - DOI: 10.1152/physiol.00023.2016
Cotter K, Liberman R, Sun-Wada G, Wada Y, Sgroi D, Naber S, Brown D, Breton S, Forgac M
The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer.
Oncotarget. 2016;7(29):46142-46157 - PMID: 27323815 - PMCID: PMC5216787 - DOI: 10.18632/oncotarget.10063
Inoue Y, Yu YM, Kurihara T, Vasilyev A, Ibrahim A, Oklu R, Zhao G, Nair AV, Brown D, Fischman AJ, Tompkins RG, Irimia D
Kidney and Liver Injuries After Major Burns in Rats Are Prevented by Resolvin D2.
Crit Care Med. 2016;44(5):e241-52 - PMID: 26509319 - PMCID: PMC4833510 - DOI: 10.1097/CCM.0000000000001397
Mamuya FA, Cano-Peñalver JL, Li WU, Rodriguez-Puyol D, Rodríguez-Puyol M, Brown D, de Frutos S, Lu HJ
ILK and Cytoskeletal Architecture: An Important Determinant of AQP2 Recycling and Subsequent Entry into the Exocytotic Pathway.
Am J Physiol Renal Physiol. 2016;311(6):F1346-F1357 - PMID: 27760768 - PMCID: PMC5210194 - DOI: 10.1152/ajprenal.00336.2016
Dutta P, Sager HB, Stengel KR, Naxerova K, Courties G, Saez B, Silberstein L, Heidt T, Sebas M, Sun Y, Wojtkiewicz G, Feruglio PF, King K, Baker JN, van der Laan AM, Borodovsky A, Fitzgerald K, Hulsmans M, Hoyer F, Iwamoto Y, Vinegoni C, Brown D, Di Carli M, Libby P, Hiebert SW, Scadden DT, Swirski FK, Weissleder R, Nahrendorf M
Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells
Cell Stem Cell. 2015;16 (5):477-487 - PMID: 25957903 - PMCID: PMC4426344 - DOI: 10.1016/j.stem.2015.04.008
Nair AV, Keliher EJ, Core AB, Brown D, Weissleder R
Characterizing the Interactions of Organic Nanoparticles with Renal Epithelial Cells in Vivo.
ACS Nano. 2015;9(4):3641-53 - PMID: 25790730 - PMCID: PMC4414893 - DOI: 10.1021/acsnano.5b00428
Merkulova M, Păunescu TG, Azroyan A, Marshansky V, Breton S, Brown D
Mapping the H(+) (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation.
Sci Rep. 2015;5:14827 - PMID: 26442671 - PMCID: PMC4595830 - DOI: 10.1038/srep14827
Azroyan A, Cortez-Retamozo V, Bouley R, Liberman R, Ruan YC, Kiselev E, Jacobson KA, Pittet MJ, Brown D, Breton S
Renal Intercalated Cells Sense and Mediate Inflammation via the P2Y14 Receptor.
PLoS ONE. 2015;10(3):e0121419 - PMID: 25799465 - PMCID: PMC4370445 - DOI: 10.1371/journal.pone.0121419
Arthur J, Huang J, Nomura N, Jin WW, Li W, Cheng X, Brown D, Lu HJ
Characterization of the putative phosphorylation sites of the AQP2 c-terminus and their role in AQP2 trafficking in LLC-PK1 cells.
Am J Physiol Renal Physiol. 2015;309(8):F673-9 - PMID: 26290367 - PMCID: PMC4609919 - DOI: 10.1152/ajprenal.00152.2015
Herak-Kramberger CM, Breljak D, Ljubojević M, Matokanovic M, Lovric M, Rogic D, Brzica H, Vrhovac I, Karaica D, Micek V, Ivkovic Dupor J, Brown D, Sabolic I
Sex-dependent expression of water channel AQP1 along the rat nephron.
Am J Physiol Renal Physiol. 2015;308(8):F809-21 - PMID: 25656365 - PMCID: PMC4398837 - DOI: 10.1152/ajprenal.00368.2014
Ruan YC, Wang Y, Da Silva N, Kim B, Diao RY, Hill E, Brown D, Chan HC, Breton S
CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation via the ZONAB pathway.
J Cell Sci. 2014;127(Pt 20):4396-408 - PMID: 25107366 - PMCID: PMC4197086 - DOI: 10.1242/jcs.148098
Păunescu TG, Shum WW, Huynh C, Lechner L, Goetze B, Brown D, Breton S
High-resolution helium ion microscopy of epididymal epithelial cells and their interaction with spermatozoa.
Mol Hum Reprod. 2014;20(10):929-37 - PMID: 25015675 - PMCID: PMC4172170 - DOI: 10.1093/molehr/gau052
Miranda KC, Bond DT, Levin JZ, Adiconis X, Sivachenko A, Russ C, Brown D, Nusbaum C, Russo LM
Massively parallel sequencing of human urinary exosome/microvesicle RNA reveals a predominance of non-coding RNA.
PLoS ONE. 2014;9(5):e96094 - PMID: 24816817 - PMCID: PMC4015934 - DOI: 10.1371/journal.pone.0096094
Nomura N, Nunes P, Bouley R, Nair AV, Shaw S, Ueda E, Pathomthongtaweechai N, Lu HA, Brown D
High throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration.
Am J Physiol Cell Physiol. 2014;307(7):C597-605 - PMID: 24944200 - PMCID: PMC4187055 - DOI: 10.1152/ajpcell.00154.2014
Nunes P, Ernandez T, Roth I, Qiao X, Strebel D, Bouley R, Charollais A, Ramadori P, Foti M, Meda P, Féraille E, Brown D, Hasler U
Hypertonic stress promotes autophagy and microtubule-dependent autophagosomal clusters.
Autophagy. 2013;9(4):550-67 - PMID: 23380587 - PMCID: PMC3627670 - DOI: 10.4161/auto.23662
Brown D, Jenny Lu HA
Aquaporin-2 Inhibitors: Fishing in the Chemical Pool.
J Am Soc Nephrol. 2013;24(5):685-6 - PMID: 23599384 - DOI: 10.1681/ASN.2013030243
Little MH, Brown D, Humphreys BD, McMahon AP, Miner JH, Sands JM, Weisz OA, Mullins C, Hoshizaki D,
Defining Kidney Biology to Understand Renal Disease.
Clin J Am Soc Nephrol. 2013;9(4):809-11 - PMID: 24370769 - PMCID: PMC3974369 - DOI: 10.2215/CJN.10851013
Breton S, Brown D
Regulation of Luminal Acidification by the V-ATPase.
Physiology (Bethesda). 2013;28(5):318-29 - PMID: 23997191 - PMCID: PMC3768094 - DOI: 10.1152/physiol.00007.2013
Feinstein TN, Yui N, Webber MJ, Wehbi VL, Stevenson HP, King JD, Hallows KR, Brown D, Bouley R, Vilardaga JP
Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin.
J Biol Chem. 2013;288(39):27849-60 - PMID: 23935101 - PMCID: PMC3784700 - DOI: 10.1074/jbc.M112.445098
Rice WL, Van Hoek AN, Păunescu TG, Huynh C, Goetze B, Singh B, Scipioni L, Stern LA, Brown D
High resolution helium ion scanning microscopy of the rat kidney.
PLoS ONE. 2013;8(3):e57051 - PMID: 23505418 - PMCID: PMC3591388 - DOI: 10.1371/journal.pone.0057051
Roy JW, Hill E, Ruan YC, Vedovelli L, Paunescu T, Brown D, Breton S
Circulating aldosterone induces the apical accumulation of the proton pumping V-ATPase and increases proton secretion in clear cells in the caput epididymis.
Am J Physiol Cell Physiol. 2013;305(4):C436-46 - PMID: 23761626 - PMCID: PMC3891217 - DOI: 10.1152/ajpcell.00410.2012
Paunescu TG, Lu HA, Russo LM, Pastor-Soler NM, McKee M, McLaughlin MM, Bartlett BE, Breton S, Brown D
Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells.
Am J Physiol Renal Physiol. 2013;305(12):F1783-F1795 - PMID: 24133120 - PMCID: PMC3882446 - DOI: 10.1152/ajprenal.00622.2012
Shum W, Hill E, Brown D, Breton S
Plasticity of basal cells during postnatal development in the rat epididymis.
Reproduction. 2013;146(5):455-469 - PMID: 23960170 - PMCID: PMC4106237 - DOI: 10.1530/REP-12-0510
Chen Y, Rice W, Gu Z, Li J, Huang J, Brenner MB, Van Hoek A, Xiong J, Gundersen GG, Norman JC, Hsu VW, Fenton RA, Brown D, Lu HA
Aquaporin 2 Promotes Cell Migration and Epithelial Morphogenesis.
J Am Soc Nephrol. 2012;23(9):1506-17 - PMID: 22859853 - PMCID: PMC3431417 - DOI: 10.1681/ASN.2012010079
Brown D, Wagner CA
Molecular Mechanisms of Acid-Base Sensing by the Kidney.
J Am Soc Nephrol. 2012;23(5):774-80 - PMID: 22362904 - PMCID: PMC3338302 - DOI: 10.1681/ASN.2012010029
Fan X, Li Q, Pisarek-Horowitz A, Rasouly HM, Wang X, Bonegio RG, Wang H, McLaughlin M, Mangos S, Kalluri R, Holzman LB, Drummond IA, Brown D, Salant DJ, Lu W
Inhibitory Effects of Robo2 on Nephrin: A Crosstalk between Positive and Negative Signals Regulating Podocyte Structure.
Cell Rep. 2012;2(1):52-61 - PMID: 22840396 - PMCID: PMC3627357 - DOI: 10.1016/j.celrep.2012.06.002
Hennings JC, Picard N, Huebner AK, Stauber T, Maier H, Brown D, Jentsch TJ, Vargas-Poussou R, Eladari D, Hübner CA
A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule.
EMBO Mol Med. 2012;4(10):1057-71 - PMID: 22933323 - PMCID: PMC3491836 - DOI: 10.1002/emmm.201201527
Păunescu TG, Rodriguez S, Benz E, McKee M, Tyszkowski R, Albers MW, Brown D
Loss of the V-ATPase B1 Subunit Isoform Expressed in Non-Neuronal Cells of the Mouse Olfactory Epithelium Impairs Olfactory Function.
PLoS ONE. 2012;7(9):e45395 - PMID: 23028982 - PMCID: PMC3447883 - DOI: 10.1371/journal.pone.0045395
Staropoli JF, Haliw L, Biswas S, Garrett L, Hölter SM, Becker L, Skosyrski S, Da Silva-Buttkus P, Calzada-Wack J, Neff F, Rathkolb B, Rozman J, Schrewe A, Adler T, Puk O, Sun M, Favor J, Racz I, Bekeredjian R, Busch DH, Graw J, Klingenspor M, Klopstock T, Wolf E, Wurst W, Zimmer A, Lopez E, Harati H, Hill E, Krause DS, Guide J, Dragileva E, Gale E, Wheeler VC, Boustany RM, Brown DE, Breton S, Ruether K, Gailus-Durner V, Fuchs H, de Angelis MH, Cotman SL
Large-Scale Phenotyping of an Accurate Genetic Mouse Model of JNCL Identifies Novel Early Pathology Outside the Central Nervous System.
PLoS ONE. 2012;7(6):e38310 - PMID: 22701626 - PMCID: PMC3368842 - DOI: 10.1371/journal.pone.0038310
Rice WL, Zhang Y, Chen Y, Matsuzaki T, Brown D, Lu HA
Differential, Phosphorylation Dependent Trafficking of AQP2 in LLC-PK1 Cells.
PLoS ONE. 2012;7(2):e32843 - PMID: 22403603 - PMCID: PMC3293519 - DOI: 10.1371/journal.pone.0032843
Yui N, Lu HA, Chen Y, Nomura N, Bouley R, Brown D
Basolateral targeting and microtubule dependent transcytosis of the aquaporin-2 water channel.
Am J Physiol Cell Physiol. 2012;304(1):C38-48 - PMID: 23015545 - PMCID: PMC3543574 - DOI: 10.1152/ajpcell.00109.2012
Brown D, Bouley R, Paunescu TG, Breton S, Lu HA
New insights into the dynamic regulation of water and acid/base balance by renal epithelial cells.
Am J Physiol Cell Physiol. 2012;302(10):C1421-33 - PMID: 22460710 - PMCID: PMC3362000 - DOI: 10.1152/ajpcell.00085.2012
Vedovelli L, Rothermel JT, Finberg KE, Wagner CA, Azroyan A, Hill E, Breton S, Brown D, Paunescu TG
Altered V-ATPase expression in renal intercalated cells isolated from B1-subunit deficient mice by fluorescence activated cell sorting.
Am J Physiol Renal Physiol. 2012;304(5):F522-32 - PMID: 23269648 - PMCID: PMC3602708 - DOI: 10.1152/ajprenal.00394.2012
Bouley R, Nunes P, Andriopoulos B, McLaughlin MM, Webber MJ, Lin HY, Babitt JL, Gardella TJ, Ausiello DA, Brown D
Heterologous downregulation of vasopressin type 2 receptor is induced by transferrin.
Am J Physiol Renal Physiol. 2012;304(5):F553-64 - PMID: 23235478 - PMCID: PMC3602717 - DOI: 10.1152/ajprenal.00438.2011
Chen S, Webber MJ, Vilardaga JP, Khatri A, Brown D, Ausiello DA, Lin HY, Bouley R
Visualizing Microtubule-Dependent Vasopressin Type 2 Receptor Trafficking Using a New High-Affinity Fluorescent Vasopressin Ligand.
Endocrinology. 2011;152(10):3893-904 - PMID: 21828182 - PMCID: PMC3176653 - DOI: 10.1210/en.2011-1049
Winter C, Kampik NB, Vedovelli L, Rothenberger F, Paunescu TG, Stehberger PA, Brown D, John H, Wagner CA
Aldosterone stimulates vacuolar H+-ATPase activity in renal acid-secretory intercalated cells mainly via a protein kinase C dependent pathway.
Am J Physiol Cell Physiol. 2011;301(5):C1251-61 - PMID: 21832245 - PMCID: PMC3213922 - DOI: 10.1152/ajpcell.00076.2011
Shum WW, Da Silva N, Belleannee C, McKee M, Brown D, Breton S
Regulation of V-ATPase recycling via a RhoA and ROCKII dependent pathway in epididymal clear cells.
Am J Physiol Cell Physiol. 2011;301(1):C31-43 - PMID: 21411727 - PMCID: PMC3129830 - DOI: 10.1152/ajpcell.00198.2010
Merkulova M, Hurtado-Lorenzo A, Hosokawa H, Zhuang Z, Brown D, Ausiello DA, Marshansky V
Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution.
Am J Physiol Cell Physiol. 2011;300(6):C1442-55 - PMID: 21307348 - PMCID: PMC3118619 - DOI: 10.1152/ajpcell.00076.2010
Li W, Zhang Y, Bouley R, Chen Y, Matsuzaki T, Nunes P, Hasler U, Brown D, Lu HA
Simvastatin Enhances Aquaporin 2 Surface Expression and Urinary Concentration in Vasopressin Deficient Brattleboro Rats through Modulation of Rho GTPase.
Am J Physiol Renal Physiol. 2011;301(2):F309-18 - PMID: 21511701 - PMCID: PMC3154588 - DOI: 10.1152/ajprenal.00001.2011
Da Silva N, Cortez-Retamozo V, Reinecker HC, Wildgruber M, Hill E, Brown D, Swirski F, Pittet M, Breton S
A dense network of dendritic cells populates the murine epididymis.
Reproduction. 2011;141(5):653-63 - PMID: 21310816 - PMCID: PMC3657760 - DOI: 10.1530/REP-10-0493
Wagner CA, Mohebbi N, Uhlig U, Giebisch GH, Breton S, Brown D, Geibel JP
Angiotensin II Stimulates H-ATPase Activity in Intercalated Cells from Isolated Mouse Connecting Tubules and Cortical Collecting Ducts.
Cell Physiol Biochem. 2011;28(3):513-20 - PMID: 22116365 - PMCID: PMC3709473 - DOI: 10.1159/000335112
Yui N, Lu HJ, Bouley R, Brown D
AQP2 is necessary for vasopressin- and forskolin-mediated filamentous actin depolymerization in renal epithelial cells.
Biol Open. 2011;1(2):101-8 - PMID: 23213402 - PMCID: PMC3507199 - DOI: 10.1242/bio.2011042
Gao X, Eladari D, Leviel F, Tew BY, Miro-Julia
Deletion of hensin/DMBT1 blocks conversion of {beta}- to {alpha}-intercalated cells and induces distal renal tubular acidosis.
Proc Natl Acad Sci U S A. 2010;107(50):21872-7 - PMID: 21098262 - PMCID: PMC3003085 - DOI: 10.1073/pnas.1010364107
Bouley R, Lu HA, Nunes P, Da Silva N, McLaughlin M, Chen Y, Brown D
Calcitonin Has a Vasopressin-like Effect on Aquaporin-2 Trafficking and Urinary Concentration.
J Am Soc Nephrol. 2010;22(1):59-72 - PMID: 21071524 - PMCID: PMC3014035 - DOI: 10.1681/ASN.2009121267
Schreiner R, Frindt G, Diaz F, Carvajal-Gonzalez JM, Perez Bay AE, Palmer LG, Marshansky V, Brown D, Philp NJ, Rodriguez-Boulan E
The absence of a clathrin adapter confers unique polarity essential to proximal tubule function.
Kidney Int. 2010;78(4):382-8 - PMID: 20531453 - PMCID: PMC3684398 - DOI: 10.1038/ki.2010.166
Miranda KC, Bond DT, McKee M, Skog J, Paunescu TG, Da Silva N, Brown D, Russo LM
Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease.
Kidney Int. 2010;78(2):191-9 - PMID: 20428099 - PMCID: PMC4451567 - DOI: 10.1038/ki.2010.106
Miranda KC, Karet FE, Brown D
An Extended Nomenclature for Mammalian V-ATPase Subunit Genes and Splice Variants.
PLoS ONE. 2010;5(3):e9531 - PMID: 20224822 - PMCID: PMC2835735 - DOI: 10.1371/journal.pone.0009531
Belleannee C, Da Silva N, Shum WW, Brown D, Breton S
Role of purinergic signaling pathways in V-ATPase recruitment to the apical membrane of acidifying epididymal clear cells.
Am J Physiol Cell Physiol. 2010;298(4):C817-30 - PMID: 20071692 - PMCID: PMC2853219 - DOI: 10.1152/ajpcell.00460.2009
Zhuang Z, Marshansky V, Breton S, Brown D
Is caveolin involved in normal proximal tubule (PT) function? Presence in model PT systems but absence in situ.
Am J Physiol Renal Physiol. 2010;300(1):F199-206 - PMID: 20980408 - PMCID: PMC3023221 - DOI: 10.1152/ajprenal.00513.2010
Paunescu TG, Ljubojevic M, Russo LM, Winter C, McLaughlin MM, Wagner CA, Breton S, Brown D
Cyclic AMP stimulates apical V-ATPase accumulation, microvillar elongation and proton extrusion in kidney collecting duct A-intercalated cells.
Am J Physiol Renal Physiol. 2010;298(3):F643-54 - PMID: 20053793 - PMCID: PMC2838605 - DOI: 10.1152/ajprenal.00584.2009
Brown D, Breton S, Ausiello DA, Marshansky V
Sensing, Signaling and Sorting Events in Kidney Epithelial Cell Physiology.
Traffic. 2009;10(3):275-84 - PMID: 19170982 - PMCID: PMC2896909 - DOI: 10.1111/j.1600-0854.2008.00867.x
Belleannee C, Da Silva N, Shum WW, Marsolais M, Laprade R, Brown D, Breton S
Segmental Expression of the Bradykinin Type 2 Receptor in Rat Efferent Ducts and Epididymis and Its Role in the Regulation of Aquaporin 9.
Biol Reprod. 2009;80(1):134-43 - PMID: 18829705 - PMCID: PMC2804812 - DOI: 10.1095/biolreprod.108.070797
Comper WD, Russo LM
The glomerular filter: an imperfect barrier is required for perfect renal function.
Curr Opin Nephrol Hypertens. 2009;18(4):336-42 - PMID: 19474730 - DOI: 10.1097/MNH.0b013e32832cb96a
Bouley R, Palomino Z, Tang SS, Nunes P, Kobori H, Lu HA, Shum WW, Sabolic I, Brown D, Ingelfinger JR, Jung FF
Angiotensin II and Hypertonicity Modulate Proximal Tubular Aquaporin 1 (AQP1) Expression.
Am J Physiol Renal Physiol. 2009;297(6):F1575-86 - PMID: 19776169 - PMCID: PMC2801332 - DOI: 10.1152/ajprenal.90762.2008
Van Hoek AN, Bouley R, Lu YX, Silberstein CM, Brown D, Wax MB, Patil RV
Vasopressin-induced differential stimulation of AQP4 splice variants regulates the in-membrane assembly of orthogonal arrays.
Am J Physiol Renal Physiol. 2009;296(6):F1396-404 - PMID: 19297454 - PMCID: PMC2692439 - DOI: 10.1152/ajprenal.00018.2009
Pastor-Soler NM, Fisher JS, Sharpe R, Hill E, Van Hoek A, Brown D, Breton S
Aquaporin 9 expression in the developing rat epididymis is modulated by steroid hormones.
Reproduction. 2009;139(3):613-21 - PMID: 19948840 - PMCID: PMC3773695 - DOI: 10.1530/REP-09-0284
Brown D, Paunescu TG, Breton S, Marshansky V
Regulation of the V-ATPase in kidney epithelial cells: dual role in acid-base homeostasis and vesicle trafficking.
J Exp Biol. 2009;212(Pt 11):1762-72 - PMID: 19448085 - PMCID: PMC2683016 - DOI: 10.1242/jeb.028803
Shum WW, Da Silva N, Brown D, Breton S
Regulation of luminal acidification in the male reproductive tract via cell-cell crosstalk.
J Exp Biol. 2009;212(Pt 11):1753-61 - PMID: 19448084 - PMCID: PMC2683015 - DOI: 10.1242/jeb.027284
Shum WW, Da Silva N, McKee M, Smith PJ, Brown D, Breton S
Transepithelial Projections from Basal Cells are Luminal Sensors in Pseudostratified Epithelia
Cell. 2008;135:1108-17 - PMID: 19070580 - PMCID: PMC2646085 - DOI: 10.1016/j.cell.2008.10.020
Russo LM, Sandoval RM, Campos SB, Molitoris BA, Comper WD, Brown D
Impaired Tubular Uptake Explains Albuminuria in Early Diabetic Nephropathy.
J Am Soc Nephrol. 2008;20(3):489-94 - PMID: 19118149 - PMCID: PMC2653682 - DOI: 10.1681/ASN.2008050503
Miller RL, Lucero OM, Riemondy KA, Baumgartner BK, Brown D, Breton S, Nelson RD
The V-ATPase B1-subunit promoter drives expression of Cre recombinase in intercalated cells of the kidney.
Kidney Int. 2008;75(4):435-9 - PMID: 19052537 - PMCID: PMC4301582 - DOI: 10.1038/ki.2008.569
Zalyapin EA, Bouley R, Hasler U, Vilardaga JP, Lin HY, Brown D, Ausiello DA
Effects of the renal medullary pH and ionic environment on vasopressin binding and signaling.
Kidney Int. 2008;74(12):1557-67 - PMID: 18813286 - PMCID: PMC3730289 - DOI: 10.1038/ki.2008.412
Pietrement C, Da Silva N, Silberstein C, James M, Marsolais M, Van Hoek A, Brown D, Pastor-Soler N, Ameen N, Laprade R, Ramesh V, Breton S
Role of NHERF1, CFTR and cAMP in the regulation of aquaporin 9
J Biol Chem. 2008;283:2986-96 - PMID: 18055461 - DOI: 10.1074/jbc.M704678200
Hasler U, Nunes P, Bouley R, Lu HA, Matsuzaki T, Brown D
Acute hypertonicity alters aquaporin-2 trafficking and induces a MAP kinase-dependent accumulation at the plasma membrane of renal epithelial cells.
J Biol Chem. 2008;283(39):26643-61 - PMID: 18664568 - PMCID: PMC2546545 - DOI: 10.1074/jbc.M801071200
Russo LM, Brown D, Lin HY
The soluble transforming growth factor-beta receptor: Advantages and applications.
Int J Biochem Cell B. 2008;41(3):472-6 - PMID: 18339576 - DOI: 10.1016/j.biocel.2008.01.026
Brown D, Hasler U, Nunes P, Bouley R, Lu H
Phosphorylation events and the modulation of aquaporin 2 cell surface expression.
Curr Opin Nephrol Hypertens. 2008;17(5):491-8 - PMID: 18695390 - PMCID: PMC3774073 - DOI: 10.1097/MNH.0b013e3283094eb1
Nunes P, Hasler U, McKee M, Lu HA, Bouley R, Brown D
A fluorimetry-based ssYFP secretion assay to monitor vasopressin-induced exocytosis in LLC-PK1 cells expressing aquaporin-2 (AQP2).
Am J Physiol Cell Physiol. 2008;295(6):C1476-87 - PMID: 18799651 - PMCID: PMC2603565 - DOI: 10.1152/ajpcell.00344.2008
Paunescu TG, Jones AC, Tyszkowski R, Brown D
V-ATPase expression in the mouse olfactory epithelium.
Am J Physiol Cell Physiol. 2008;295(4):C923-30 - PMID: 18667600 - PMCID: PMC2575830 - DOI: 10.1152/ajpcell.00237.2008
Lu HA, Matsuzaki T, Bouley R, Hasler U, Qin Q, Brown D
The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells.
Am J Physiol Renal Physiol. 2008;295(1):F290-4 - PMID: 18434387 - PMCID: PMC2494506 - DOI: 10.1152/ajprenal.00072.2008
Bouley R, Hasler U, Lu HA, Nunes P, Brown D
Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidus.
Semin Nephrol. 2008;28:266-78 - PMID: 18519087 - PMCID: PMC2494582 - DOI: 10.1016/j.semnephrol.2008.03.010
Russo LM, Sandoval RM, Brown D, Molitoris BA, Comper WD
Controversies in nephrology: Response to ''renal albumin handling, facts, and artifacts''
Kidney Int. 2007;72(10):1195-7 - PMID: 17851467 - DOI: 10.1038/sj.ki.5002528
Russo LM, Sandoval RM, Brown D, Molitoris BA, Comper WD
Response to ''Albumin concentration in the Bowman's capsule: Multiphoton microscopy vs micropuncture technique''
Kidney Int. 2007;72:1411 - PMID: 18004315
Russo LM, Sandoval RM, Brown D, Molitoris BA, Comper WD
Response to ''On the origin of albuminuria''
Kidney Int. 2007;72:1409-10 - PMID: 18004312
Russo LM, Sandoval RM, McKee M, Osicka TM, Collins AB, Brown D, Molitoris BA, Comper WD
The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: retrieval is disrupted in nephrotic states.
Kidney Int. 2007;71(6):504-13 - PMID: 17228368 - DOI: 10.1038/sj.ki.5002041
Russo LM, del Re E, Brown D, Lin HY
Evidence for a role of transforming growth factor (TGF)-beta1 in the induction of postglomerular albuminuria in diabetic nephropathy: amelioration by soluble TGF-beta type II receptor.
Diabetes. 2007;56(2):380-8 - PMID: 17259382 - DOI: 10.2337/db06-1018
Lu HA, Sun TX, Matsuzaki T, Yi XH, Eswara J, Bouley R, McKee M, Brown D
Heat shock protein 70 interacts with aquaporin-2 (AQP2) and regulates its trafficking.
J Biol Chem. 2007;282(39):28721-32 - PMID: 17636261 - DOI: 10.1074/jbc.M611101200
Da Silva N, Shum WW, El-Annan J, Paunescu TG, McKee M, Smith PJ, Brown D, Breton S
Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit.
Am J Physiol Cell Physiol. 2007;293(1):C199-210 - PMID: 17392376 - DOI: 10.1152/ajpcell.00596.2006
Paunescu TG, Da Silva N, Russo LM, McKee M, Lu HA, Breton S, Brown D
Association Of Soluble Adenylyl Cyclase (sAC) With The V-ATPase In Renal Epithelial Cells.
Am J Physiol Renal Physiol. 2007;294(1):F130-8 - PMID: 17959750 - DOI: 10.1152/ajprenal.00406.2007
Paunescu TG, Russo LM, Da Silva N, Kovacikova J, Mohebbi N, Van Hoek AN, McKee M, Wagner CA, Breton S, Brown D
Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice.
Am J Physiol Renal Physiol. 2007;293(6):F1915-26 - PMID: 17898041 - DOI: 10.1152/ajprenal.00160.2007
Yi X, Bouley R, Lin HY, Bechoua S, Sun TX, Del Re E, Shioda T, Raychowdhury MK, Lu HA, Abou-Samra AB, Brown D, Ausiello DA
Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R.
Am J Physiol Renal Physiol. 2007;292(5):F1303-13 - PMID: 17287200 - DOI: 10.1152/ajprenal.00441.2005
Marshansky V
The V-ATPase a2-subunit as a putative endosomal pH-sensor.
Biochem Soc T. 2007;35:1092-9 - PMID: 17956287 - DOI: 10.1042/BST0351092
Hurtado-Lorenzo A, Skinner M, El Annan J, Futai M, Sun-Wada GH, Bourgoin S, Casanova J, Wildeman A, Bechoua S, Ausiello DA, Brown D, Marshansky V
V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway.
Nat Cell Biol. 2006;8(2):124-36 - PMID: 16415858 - DOI: 10.1038/ncb1348
Vilardaga JP
Switching modes for G protein-coupled receptor activation.
Nat Chem Biol. 2006;2(8):395-6 - PMID: 16850011 - DOI: 10.1038/nchembio0806-395
Da Silva N, Pietrement C, Brown D, Breton S
Segmental and cellular expression of aquaporins in the male excurrent duct.
Biochim Biophys Acta. 2006;1758(8):1025-33 - PMID: 16935257 - DOI: 10.1016/j.bbamem.2006.06.026
Breton S, Brown D
New insights into the regulation of V-ATPase-dependent proton secretion.
Am J Physiol Renal Physiol. 2006;292(1):F1-10 - PMID: 17032935 - DOI: 10.1152/ajprenal.00340.2006
Bouley R, Hawthorn G, Russo L, Lin H, Ausiello D, Brown D
Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment.
Biol Cell. 2006;98(4):215-32 - PMID: 16563128 - DOI: 10.1042/BC20040054
Pietrement C, Sun-Wada GH, Silva ND, McKee M, Marshansky V, Brown D, Futai M, Breton S
Distinct expression patterns of different subunit isoforms of the V-ATPase in the rat epididymis.
Biol Reprod. 2005;74(1):185-94 - PMID: 16192400 - DOI: 10.1095/biolreprod.105.043752
Da Silva N, Silberstein C, Beaulieu V, Pietrement C, Van Hoek AN, Brown D, Breton S
Postnatal expression of aquaporins in epithelial cells of the rat epididymis.
Biol Reprod. 2005;74(2):427-38 - PMID: 16221990 - DOI: 10.1095/biolreprod.105.044735
Sabolic I, Herak-Kramberger CM, Antolovic R, Breton S, Brown D
Loss of basolateral invaginations in proximal tubules of cadmium-intoxicated rats is independent of microtubules and clathrin.
Toxicology. 2005;218(2-3):149-63 - PMID: 16288946 - DOI: 10.1016/j.tox.2005.10.009
Lisi S, Botta R, Pinchera A, Collins AB, Refetoff S, Arvan P, Bu G, Grasso L, Marshansky V, Bechoua S, Hurtado-Lorenzo A, Marcocci C, Brown D, McCluskey RT, Marinò M
Defective thyroglobulin storage in LDL receptor-associated protein-deficient mice.
Am J Physiol Cell Physiol. 2005;290(4):C1160-7 - PMID: 16306127 - DOI: 10.1152/ajpcell.00382.2005
Bouley R, Lin HY, Raychowdhury MK, Marshansky V, Brown D, Ausiello DA
Downregulation of the vasopressin type 2 receptor after vasopressin-induced internalization: involvement of a lysosomal degradation pathway.
Am J Physiol Cell Physiol. 2005;288(6):C1390-401 - PMID: 15677378 - DOI: 10.1152/ajpcell.00353.2004
Miller RL, Zhang P, Smith M, Beaulieu V, Paunescu TG, Brown D, Breton S, Nelson RD
V-ATPase B1-subunit promoter drives expression of EGFP in intercalated cells of kidney, clear cells of epididymis and airway cells of lung in transgenic mice.
Am J Physiol Cell Physiol. 2005;288(5):C1134-44 - PMID: 15634743 - DOI: 10.1152/ajpcell.00084.2004
Bouley R, Hawthorn G, Russo L, Lin HY, Ausiello D, Brown D
Aquaporin 2 (AQP2) and vasopressin receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in "endocytosis-resistant" membrane domains after vasopressin treatment.
Abdom Imaging. 2005;:ePub - PMID: 16104839
Paunescu TG, Da Silva N, Marshansky V, McKee M, Breton S, Brown D
Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis.
Am J Physiol Cell Physiol. 2004;287(1):C149-62 - PMID: 15013950 - DOI: 10.1152/ajpcell.00464.2003
Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, Geibel JP
Renal vacuolar H+-ATPase.
2004;84(4):1263-314 - PMID: 15383652 - DOI: 10.1152/physrev.00045.2003
Wagner CA, L
A rapid enzymatic method for the isolation of defined kidney tubule fragments from mouse.
Pflug Arch Eur J Phy. 2003;446(5):623-32 - PMID: 12748863 - DOI: 10.1007/s00424-003-1082-3
Pastor-Soler N, Beaulieu V, Litvin TN, Da Silva N, Chen Y, Brown D, Buck J, Levin LR, Breton S
Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling.
J Biol Chem. 2003;278(49):49523-9 - PMID: 14512417 - PMCID: PMC3652382 - DOI: 10.1074/jbc.M309543200
El-Annan J, Brown D, Breton S, Bourgoin S, Ausiello DA, Marshansky V
Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situ.
Am J Physiol Cell Physiol. 2003;286(4):C768-78 - PMID: 14684384 - DOI: 10.1152/ajpcell.00250.2003
Isnard-Bagnis C, Da Silva N, Beaulieu V, Yu AS, Brown D, Breton S
Detection of ClC-3 and ClC-5 in epididymal epithelium: immunofluorescence and RT-PCR after LCM.
Am J Physiol Cell Physiol. 2003;284(1):C220-32 - PMID: 12475763 - DOI: 10.1152/ajpcell.00374.2001
van Balkom BW, van Raak M, Breton S, Pastor-Soler N, Bouley R, van der Sluijs P, Brown D, Deen PM
Hypertonicity is involved in redirecting the aquaporin-2 water channel into the basolateral, instead of the apical, plasma membrane of renal epithelial cells.
J Biol Chem. 2002;278(2):1101-7 - PMID: 12374804 - DOI: 10.1074/jbc.M207339200
Pastor-Soler N, Isnard-Bagnis C, Herak-Kramberger C, Sabolic I, Van Hoek A, Brown D, Breton S
Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens.
Biol Reprod. 2002;66(6):1716-22 - PMID: 12021052 - DOI: 10.1095/biolreprod66.6.1716
Marshansky V, Ausiello DA, Brown D
Physiological importance of endosomal acidification: potential role in proximal tubulopathies.
Curr Opin Nephrol Hypertens. 2002;11(5):527-37 - PMID: 12187318 - DOI: 10.1097/00041552-200209000-00009
Zharkikh L, Zhu X, Stricklett PK, Kohan DE, Chipman G, Breton S, Brown D, Nelson RD
Renal principal cell-specific expression of green fluorescent protein in transgenic mice.
Am J Physiol Renal Physiol. 2002;283(6):F1351-64 - PMID: 12426236 - DOI: 10.1152/ajprenal.0224.2001
Breton S, Inoue T, Knepper MA, Brown D
Antigen retrieval reveals widespread basolateral expression of syntaxin 3 in renal epithelia.
Am J Physiol Renal Physiol. 2002;282(3):F523-9 - PMID: 11832435 - DOI: 10.1152/ajprenal.00128.2001
Maranda B, Brown D, Bourgoin S, Casanova JE, Vinay P, Ausiello DA, Marshansky V
Intra-endosomal pH-sensitive recruitment of the Arf-nucleotide exchange factor ARNO and Arf6 from cytoplasm to proximal tubule endosomes.
J Biol Chem. 2001;276(21):18540-50 - PMID: 11278939 - DOI: 10.1074/jbc.M011577200
Pastor-Soler N, Bagnis C, Sabolic I, Tyszkowski R, McKee M, Van Hoek A, Breton S, Brown D
Aquaporin 9 expression along the male reproductive tract.
Biol Reprod. 2001;65(2):384-93 - PMID: 11466204 - DOI: 10.1095/biolreprod65.2.384
Herak-Kramberger CM, Breton S, Brown D, Kraus O, Sabolic I
Distribution of the vacuolar H+ atpase along the rat and human male reproductive tract.
Biol Reprod. 2001;64(6):1699-707 - PMID: 11369598 - DOI: 10.1095/biolreprod64.6.1699
Bagnis C, Marshansky V, Breton S, Brown D
Remodeling the cellular profile of collecting ducts by chronic carbonic anhydrase inhibition.
Am J Physiol Renal Physiol. 2001;280(3):F437-48 - PMID: 11181405 - DOI: 10.1152/ajprenal.2001.280.3.F437
Tekirian TL, Merriam DE, Marshansky V, Miller J, Crowley AC, Chan H, Ausiello D, Brown D, Buxbaum JD, Xia W, Wasco W
Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments.
Brain Res Mol Brain Res. 2001;96(1-2):14-20 - PMID: 11731004 - DOI: 10.1016/s0169-328x(01)00250-9
Choukroun GJ, Marshansky V, Gustafson CE, McKee M, Hajjar RJ, Rosenzweig A, Brown D, Bonventre JV
Cytosolic phospholipase A(2) regulates golgi structure and modulates intracellular trafficking of membrane proteins.
J Clin Invest. 2000;106(8):983-93 - PMID: 11032858 - PMCID: PMC314339 - DOI: 10.1172/JCI8914
Bouley R, Breton S, Sun T, McLaughlin M, Nsumu NN, Lin HY, Ausiello DA, Brown D
Nitric oxide and atrial natriuretic factor stimulate cGMP-dependent membrane insertion of aquaporin 2 in renal epithelial cells.
J Clin Invest. 2000;106(9):1115-26 - PMID: 11067864 - PMCID: PMC301414 - DOI: 10.1172/JCI9594
Brown D, Breton S
Sorting proteins to their target membranes.
Kidney Int. 2000;57(3):816-24 - PMID: 10720934 - DOI: 10.1046/j.1523-1755.2000.00920.x
Breton S, Wiederhold T, Marshansky V, Nsumu NN, Ramesh V, Brown D
The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells.
J Biol Chem. 2000;275(24):18219-24 - PMID: 10748165 - DOI: 10.1074/jbc.M909857199
Sullivan BM, Harrison-Lavoie KJ, Marshansky V, Lin HY, Kehrl JH, Ausiello DA, Brown D, Druey KM
RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.
Mol Biol Cell. 2000;11(9):3155-68 - PMID: 10982407 - PMCID: PMC14982 - DOI: 10.1091/mbc.11.9.3155
Herak-Kramberger CM, Sabolić I, Blanusa M, Smith PJ, Brown D, Breton S
Cadmium inhibits vacuolar H(+)ATPase-mediated acidification in the rat epididymis.
Biol Reprod. 2000;63(2):599-606 - PMID: 10906070 - DOI: 10.1095/biolreprod63.2.599
Stevens AL, Breton S, Gustafson CE, Bouley R, Nelson RD, Kohan DE, Brown D
Aquaporin 2 is a vasopressin-independent, constitutive apical membrane protein in rat vas deferens.
Am J Physiol Cell Physiol. 2000;278(4):C791-802 - PMID: 10751327 - DOI: 10.1152/ajpcell.2000.278.4.C791
Silver RB, Breton S, Brown D
Potassium depletion increases proton pump (H(+)-ATPase) activity in intercalated cells of cortical collecting duct.
Am J Physiol Renal Physiol. 2000;279(1):F195-202 - PMID: 10894802 - DOI: 10.1152/ajprenal.2000.279.1.F195
Breton S, Nsumu NN, Galli T, Sabolic I, Smith PJ, Brown D
Tetanus toxin-mediated cleavage of cellubrevin inhibits proton secretion in the male reproductive tract.
Am J Physiol Renal Physiol. 2000;278(5):F717-25 - PMID: 10807583 - DOI: 10.1152/ajprenal.2000.278.5.F717
Brown D, Breton S
H(+)V-ATPase-dependent luminal acidification in the kidney collecting duct and the epididymis/vas deferens: vesicle recycling and transcytotic pathways.
J Exp Biol. 2000;203(Pt 1):137-45 - PMID: 10600682 - DOI: 10.1242/jeb.203.1.137
Sabolić I, Herak-Kramberger CM, Breton S, Brown D
Na/K-ATPase in intercalated cells along the rat nephron revealed by antigen retrieval.
J Am Soc Nephrol. 1999;10(5):913-22 - PMID: 10232676 - DOI: 10.1681/ASN.V105913
Shayakul C, Breton S, Brown D, Alper SL
Gene therapy of inherited renal tubular disease.
Am J Kidney Dis. 1999;34(2):374-9 - PMID: 10430991 - DOI: 10.1016/s0272-6386(99)70372-0
Jensen LJ, Schmitt BM, Berger UV, Nsumu NN, Boron WF, Hediger MA, Brown D, Breton S
Localization of sodium bicarbonate cotransporter (NBC) protein and messenger ribonucleic acid in rat epididymis.
Biol Reprod. 1999;60(3):573-9 - PMID: 10026101 - DOI: 10.1095/biolreprod60.3.573
Breton S, Tyszkowski R, Sabolic I, Brown D
Postnatal development of H+ ATPase (proton-pump)-rich cells in rat epididymis.
Histochem Cell Biol. 1999;111(2):97-105 - PMID: 10090570 - DOI: 10.1007/s004180050339
Breton S, Brown D
Cold-induced microtubule disruption and relocalization of membrane proteins in kidney epithelial cells.
J Am Soc Nephrol. 1998;9(2):155-66 - PMID: 9527391 - DOI: 10.1681/ASN.V92155
Zuk A, Bonventre JV, Brown D, Matlin KS
Polarity, integrin, and extracellular matrix dynamics in the postischemic rat kidney.
Am J Physiol Cell Physiol. 1998;275(3):C711-C731 - PMID: 29585718 - DOI: 10.1152/ajpcell.1998.275.3.C711
Breton S, Hammar K, Smith PJS, Brown D
Proton secretion in the male reproductive tract: involvement of Cl--independent HCO 3 - transport.
Am J Physiol Cell Physiol. 1998;275(4):C1134-C1142 - PMID: 29585324 - DOI: 10.1152/ajpcell.1998.275.4.C1134
Breton S, Hammar K, Smith PJ, Brown D
Proton secretion in the male reproductive tract: involvement of Cl--independent HCO-3 transport.
Am J Physiol. 1998;275(4 Pt 1):C1134-42 - PMID: 9755067 - DOI: 10.1152/ajpcell.1998.275.4.C1134
Breton S, Lisanti MP, Tyszkowski R, McLaughlin M, Brown D
Basolateral distribution of caveolin-1 in the kidney. Absence from H+-atpase-coated endocytic vesicles in intercalated cells.
J Histochem Cytochem. 1998;46(2):205-14 - PMID: 9446827 - DOI: 10.1177/002215549804600209
Brown D, Sabolic I, Breton S
Polarized expression of membrane proteins in renal epithelial cells: involvement of specialized transport vesicles and intracellular pathways.
Adv Nephrol Necker Hosp. 1998;27:297-315 - PMID: 9408453
Alper SL, Stuart-Tilley AK, Biemesderfer D, Shmukler BE, Brown D
Immunolocalization of AE2 anion exchanger in rat kidney.
Am J Physiol Renal Physiol. 1997;273(4):F601-F614 - PMID: 29587100 - DOI: 10.1152/ajprenal.1997.273.4.F601
Shayakul C, Kanai Y, Lee WS, Brown D, Rothstein JD, Hediger MA
Localization of the high-affinity glutamate transporter EAAC1 in rat kidney.
Am J Physiol Renal Physiol. 1997;273(6):F1023-F1029 - PMID: 29586122 - DOI: 10.1152/ajprenal.1997.273.6.F1023
Kawachi H, Kurihara H, Topham PS, Brown D, Shia MA, Orikasa M, Shimizu F, Salant DJ
Slit diaphragm-reactive nephritogenic MAb 5-1-6 alters expression of ZO-1 in rat podocytes.
Am J Physiol Renal Physiol. 1997;273(6):F984-F993 - PMID: 29586119 - DOI: 10.1152/ajprenal.1997.273.6.F984
Brown D, Lee R, Bonventre JV
Redistribution of villin to proximal tubule basolateral membranes after ischemia and reperfusion.
Am J Physiol Renal Physiol. 1997;273(6):F1003-F1012 - PMID: 29586118 - DOI: 10.1152/ajprenal.1997.273.6.F1003
Brown D, Smith PJ, Breton S
Role of V-ATPase-rich cells in acidification of the male reproductive tract.
J Exp Biol. 1997;200(Pt 2):257-62 - PMID: 9050233 - DOI: 10.1242/jeb.200.2.257
Breton S, Smith PJS, Brown D
Presence de cellules acidifiantes dans l'epididyme et le canal deferent: implication de la pompe a protons
Medecine/Sciences. 1997;13:57-61
Breton S, Smith PJ, Lui B, Brown D
Acidification of the male reproductive tract by a proton pumping (H+)-ATPase.
Nature Med. 1996;2(4):470-2 - PMID: 8597961 - DOI: 10.1038/nm0496-470
Brown D, Breton S
Mitochondria-rich, proton-secreting epithelial cells.
J Exp Biol. 1996;199(Pt 11):2345-58 - PMID: 9114500 - DOI: 10.1242/jeb.199.11.2345
Breton S, Alper SL, Gluck SL, Sly WS, Barker JE, Brown D
Depletion of intercalated cells from collecting ducts of carbonic anhydrase II-deficient (CAR2 null) mice.
Am J Physiol. 1995;269(6 Pt 2):F761-74 - PMID: 8594870 - DOI: 10.1152/ajprenal.1995.269.6.F761
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