About

Stanley Shaw's Lab

Compound selection

The Shaw laboratory seeks to discover novel ways to phenotype patients, particularly through functional assays on patient-derived cells. Our overall goal is to use patient-derived cells to understand how disease alleles affect cellular pathways, and to discover new therapeutic approaches. We utilize a mix of high-throughput screening, wet lab, bioinformatic, and patient-focused approaches. Major areas of research include:

  1. High-throughput chemical screens for functional genomics of disease alleles
  2. Extracting cardiovascular and diabetic phenotypes from Electronic Medical Records (EMRs), and linking clinical phenotypes (diagnoses, outcomes, medications) with genetic and epigenetic data. (A collaboration with the National Center for Biocomputing at Harvard Medical School and i2b2 (Informatics for Integrating Biology and the Bedside)).
  3. Chemical biology of stem cell differentiation and iPS generation
  4. Novel cellular phenotypes from clinical cohorts
  5. Synthesis and characterization of novel nanoparticle molecular imaging probes

Dr. Shaw is Co-Founder and Co-Director of the Center for Assessment Technology and Continuous Health (CATCH),which seeks to develop quantitative phenotypes, digital health tools, and integrative analytics for biomedical discovery. For more information on CATCH, please visit catch-health.org

Recent Publications (more...)

Liu Y, Shoji-Kawata S, Sumpter RM, Wei Y, Ginet V, Zhang L, Posner B, Tran KA, Green DR, Xavier RJ, Shaw SY, Clarke PG, Puyal J, Levine B
Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia.
Proc Natl Acad Sci U S A. 2013;110(51):20364-71 - PMID: 24277826 - PMCID: PMC3870705
Conway KL, Kuballa P, Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M, Aldrich LN, Villablanca EJ, Peloquin JM, Goel G, Lee IA, Mizoguchi E, Shi HN, Bhan AK, Shaw SY, Schreiber SL, Virgin HW, Shamji AF, Stappenbeck TS, Reinecker HC, Xavier RJ
Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice from Salmonella Infection.
Gastroenterology. 2013;145(6):1347-57 - PMID: 23973919 - PMCID: PMC3840157
Liao KP, Diogo D, Cui J, Cai T, Okada Y, Gainer VS, Murphy SN, Gupta N, Mirel D, Ananthakrishnan AN, Szolovits P, Shaw SY, Raychaudhuri S, Churchill S, Kohane I, Karlson EW, Plenge RM
Association between low density lipoprotein and rheumatoid arthritis genetic factors with low density lipoprotein levels in rheumatoid arthritis and non-rheumatoid arthritis controls.
Ann Rheum Dis. 2013;:ePub - PMID: 23716066 - PMCID: PMC3815491
Winkler DA, Burden FR, Yan B, Weissleder R, Tassa C, Shaw S, Epa VC
Modelling and predicting the biological effects of nanomaterials.
SAR QSAR Environ Res. 2014;25(2):161-72 - PMID: 24625316

Shaw

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