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Shao H, Im H, Castro CM, Breakefield X, Weissleder R, Lee H
New Technologies for Analysis of Extracellular Vesicles.
Chem Rev. 2018;118(4):1917-1950 - PMID: 29384376 - DOI: 10.1021/acs.chemrev.7b00534
Finucane HK, Reshef YA, Anttila V, Slowikowski K, Gusev A, Byrnes A, Gazal S, Loh PR, Lareau C, Shoresh N, Genovese G, Saunders A, Macosko E, Pollack S, , Perry JRB, Buenrostro JD, Bernstein BE, Raychaudhuri S, McCarroll S, Neale BM, Price AL
Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types.
Nat Genet. 2018;50(4):621-629 - PMID: 29632380 - PMCID: PMC5896795 - DOI: 10.1038/s41588-018-0081-4
Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong KK, Elledge SJ
Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns.
Cell. 2018;173(2):499-514.e23 - PMID: 29576454 - DOI: 10.1016/j.cell.2018.02.037
Filbin MG, Tirosh I, Hovestadt V, Shaw ML, Escalante LE, Mathewson ND, Neftel C, Frank N, Pelton K, Hebert CM, Haberler C, Yizhak K, Gojo J, Egervari K, Mount C, van Galen P, Bonal DM, Nguyen QD, Beck A, Sinai C, Czech T, Dorfer C, Goumnerova L, Lavarino C, Carcaboso AM, Mora J, Mylvaganam R, Luo CC, Peyrl A, Popović M, Azizi A, Batchelor TT, Frosch MP, Martinez-Lage M, Kieran MW, Bandopadhayay P, Beroukhim R, Fritsch G, Getz G, Rozenblatt-Rosen O, Wucherpfennig KW, Louis DN, Monje M, Slavc I, Ligon KL, Golub TR, Regev A, Bernstein BE, Suvà ML
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.
Science. 2018;360(6386):331-335 - PMID: 29674595 - PMCID: PMC5949869 - DOI: 10.1126/science.aao4750
Bajpai G, Schneider C, Wong N, Bredemeyer A, Hulsmans M, Nahrendorf M, Epelman S, Kreisel D, Liu Y, Itoh A, Shankar TS, Selzman CH, Drakos SG, Lavine KJ
The human heart contains distinct macrophage subsets with divergent origins and functions.
Nature Med. 2018;:ePub - PMID: 29892064 - DOI: 10.1038/s41591-018-0059-x
Nahrendorf M
Myeloid cell contributions to cardiovascular health and disease
Nature Med. 2018;24(6):711-720 - PMID: 29867229 - DOI: 10.1038/s41591-018-0064-0
Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM, Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, Vonderheide RH, Pittet MJ, Jain RK, Zou W, Howcroft TK, Woodhouse EC, Weinberg RA, Krummel MF
Understanding the tumor immune microenvironment (TIME) for effective therapy.
Nature Med. 2018;24(5):541-550 - PMID: 29686425 - PMCID: PMC5998822 - DOI: 10.1038/s41591-018-0014-x
Miller MA
Gold photothermal therapy: A positive for negative margins
Sci Transl Med. 2018;10(423):eaar7512 - DOI: 10.1126/scitranslmed.aar7512
Vinegoni C, Feruglio PF, Gryczynski I, Mazitschek R, Weissleder R
Fluorescence anisotropy imaging in drug discovery.
Adv Drug Deliv Rev. 2018;:ePub - PMID: 29410158 - DOI: 10.1016/j.addr.2018.01.019
Cremer S, Nahrendorf M
Myeloid Cells Remodel the Mitral Valve.
Circulation. 2018;137(23):2494-2496 - PMID: 29866774 - PMCID: PMC5992497 - DOI: 10.1161/CIRCULATIONAHA.118.033622
Yvan-Charvet L, Swirski FK
Is defective cholesterol efflux an integral inflammatory component in myelopoiesis-driven cardiovascular diseases?
Eur Heart J. 2018;39(23):2168-2171 - PMID: 29771312 - DOI: 10.1093/eurheartj/ehy269
Hulsmans M, Sager HB, Roh JD, Valero-Muñoz M, Houstis NE, Iwamoto Y, Sun Y, Wilson RM, Wojtkiewicz G, Tricot B, Osborne MT, Hung J, Vinegoni C, Naxerova K, Sosnovik DE, Zile MR, Bradshaw AD, Liao R, Tawakol A, Weissleder R, Rosenzweig A, Swirski FK, Sam F, Nahrendorf M
Cardiac macrophages promote diastolic dysfunction.
J Exp Med. 2018;215(2):423-440 - PMID: 29339450 - PMCID: PMC5789416 - DOI: 10.1084/jem.20171274 - Cover
Swirski FK, Nahrendorf M
Clonal Hematopoiesis Wages War on the Myocardium.
J Am Coll Cardiol. 2018;71(8):887-889 - PMID: 29471940 - DOI: 10.1016/j.jacc.2017.12.038
Min J, Nothing M, Coble B, Zheng H, Park J, Im H, Weber GF, Castro CM, Swirski FK, Weissleder R, Lee H
Integrated Biosensor for Rapid and Point-Of-Care Sepsis Diagnosis.
ACS Nano. 2018;12(4):3378-3384 - PMID: 29533646 - DOI: 10.1021/acsnano.7b08965
Lameijer M, Binderup T, van Leent MMT, Senders ML, Fay F, Malkus J, Sanchez-Gaytan BL, Teunissen AJP, Karakatsanis N, Robson P, Zhou X, Ye Y, Wojtkiewicz G, Tang J, Seijkens TTP, Kroon J, Stroes ESG, Kjaer A, Ochando J, Reiner T, Pérez-Medina C, Calcagno C, Fischer EA, Zhang B, Temel RE, Swirski FK, Nahrendorf M, Fayad ZA, Lutgens E, Mulder WJM, Duivenvoorden R
Efficacy and safety assessment of a TRAF6- targeted nanoimmunotherapy in atherosclerotic mice and non-human primates
Nature Biomedical Engineering. 2018;2:279–292 - DOI: 10.1038/s41551-018-0221-2
Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, Kohler RH, Pittet MJ, Weissleder R
TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.
Nature Biomedical Engineering. 2018;:ePub - DOI: 10.1038/s41551-018-0236-8
Loyer X, Zlatanova I, Devue C, Yin M, Howangyin KY, Klaihmon P, Guerin CL, Kheloufi M, Vilar J, Zannis K, Fleischmann BK, Hwang DW, Park J, Lee H, Menasche P, Silvestre JS, Boulanger CM
Intra-Cardiac Release of Extracellular Vesicles Shapes Inflammation Following Myocardial Infarction.
Circ Res. 2018;:ePub - PMID: 29592957 - DOI: 10.1161/CIRCRESAHA.117.311326
Honold L, Nahrendorf M
Resident and Monocyte-Derived Macrophages in Cardiovascular Disease.
Circ Res. 2018;122(1):113-127 - PMID: 29301844 - PMCID: PMC5777215 - DOI: 10.1161/CIRCRESAHA.117.311071
Carlson J, Mikula H, Weissleder R
Unraveling tetrazine-triggered bioorthogonal elimination enables chemical tools for ultrafast release and universal cleavage.
J Am Chem Soc. 2018;140(10):3603-3612 - PMID: 29384666 - PMCID: PMC5857921 - DOI: 10.1021/jacs.7b11217 - Cover
Shao L, Chang J, Feng W, Wang X, Williamson EA, Li Y, Schajnovitz A, Scadden D, Mortensen LJ, Lin CP, Li L, Paulson A, Downing J, Zhou D, Hromas RA
The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow.
Nat Commun. 2018;9(1):2377 - PMID: 29915352 - PMCID: PMC6006146 - DOI: 10.1038/s41467-018-04716-5
Ingram JR, Blomberg OS, Rashidian M, Ali L, Garforth S, Fedorov E, Fedorov AA, Bonanno JB, Le Gall C, Crowley S, Espinosa C, Biary T, Keliher EJ, Weissleder R, Almo SC, Dougan SK, Ploegh HL, Dougan M
Anti-CTLA-4 therapy requires an Fc domain for efficacy.
Proc Natl Acad Sci U S A. 2018;115(15):3912-3917 - PMID: 29581255 - PMCID: PMC5899492 - DOI: 10.1073/pnas.1801524115
Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, Păunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA
Reply to Edemir: Physiological regulation and single-cell RNA sequencing.
Proc Natl Acad Sci U S A. 2018;115(3):E351-E352 - PMID: 29311339 - PMCID: PMC5777009 - DOI: 10.1073/pnas.1720333115
Zhang Y, Dong H, Seeburg DP, Wojtkiewicz GR, Waterman P, Pulli B, Forghani R, Ali M, Iwamoto Y, Swirski FK, Chen JW
Multimodal Molecular Imaging Demonstrates Myeloperoxidase Regulation of Matrix Metalloproteinase Activity in Neuroinflammation.
Mol Neurobiol. 2018;:ePub - PMID: 29808380 - DOI: 10.1007/s12035-018-1137-2
Nahrendorf M, Vandoorne K
Albumin-Binding MR Probe Detects High-Risk Coronary Plaques in Patients.
JACC Cardiovasc Imaging. 2018;:ePub - PMID: 29361477 - DOI: 10.1016/j.jcmg.2017.11.026
Kim HJ, Wei Y, Wojtkiewicz GR, Lee JY, Moskowitz MA, Chen JW
Reducing myeloperoxidase activity decreases inflammation and increases cellular protection in ischemic stroke.
J Cereb Blood Flow Metab. 2018;:271678X18771978 - PMID: 29673284 - DOI: 10.1177/0271678X18771978
Yeh SA, Wilk K, Lin CP, Intini G
In Vivo 3D Histomorphometry Quantifies Bone Apposition and Skeletal Progenitor Cell Differentiation.
Sci Rep. 2018;8(1):5580 - PMID: 29615817 - PMCID: PMC5882859 - DOI: 10.1038/s41598-018-23785-6
Brannen A, Eggert M, Nahrendorf M, Arnold R, Panizzi P
Correlation of 360-degree Surface Mapping In Vivo Bioluminescence with Multi-Spectral Optoacoustic Tomography in Human Xenograft Tumor Models.
Sci Rep. 2018;8(1):3321 - PMID: 29463820 - PMCID: PMC5820276 - DOI: 10.1038/s41598-018-21668-4
Ling R, Tahir W, Lin HY, Lee H, Tian L
High-throughput intensity diffraction tomography with a computational microscope.
Biomed Opt Express. 2018;9(5):2130-2141 - PMID: 29760975 - PMCID: PMC5946776 - DOI: 10.1364/BOE.9.002130
Charan K, Li B, Wang M, Lin CP, Xu C
Fiber-based tunable repetition rate source for deep tissue two-photon fluorescence microscopy.
Biomed Opt Express. 2018;9(5):2304-2311 - PMID: 29760989 - PMCID: PMC5946790 - DOI: 10.1364/BOE.9.002304
Breton S, Brown D
Novel Proinflammatory Function of Renal Intercalated Cells.
Ann Nutr Metab. 2018;72 Suppl 2:11-16 - PMID: 29925073 - DOI: 10.1159/000488303
Ryu WS, Bae EK, Park SH, Jeong SW, Schellingerhout D, Nahrendorf M, Kim DE
Increased Left Ventricular Filling Pressure and Arterial Occlusion in Stroke Related to Atrial Fibrillation.
J Stroke Cerebrovasc Dis. 2018;27(5):1275-1282 - PMID: 29310958 - DOI: 10.1016/j.jstrokecerebrovasdis.2017.12.009
Sieg E, Brook M, Linnoila J, VanHaerents S
Neuropsychological assessment as an objective tool to monitor treatment response in anti-N-methyl-D-aspartate receptor encephalitis.
BMJ Case Rep. 2018;2018:ePub - PMID: 29884664 - DOI: 10.1136/bcr-2018-224169
Li K, Rodosthenous RS, Kashanchi F, Gingeras T, Gould SJ, Kuo LS, Kurre P, Lee H, Leonard JN, Liu H, Lombo TB, Momma S, Nolan JP, Ochocinska MJ, Pegtel DM, Sadovsky Y, Sánchez-Madrid F, Valdes KM, Vickers KC, Weaver AM, Witwer KW, Zeng Y, Das S, Raffai RL, Howcroft TK
Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop.
JCI Insight. 2018;3(7):ePub - PMID: 29618663 - PMCID: PMC5928855 - DOI: 10.1172/jci.insight.98942
Ricklefs FL, Alayo Q, Krenzlin H, Mahmoud AB, Speranza MC, Nakashima H, Hayes JL, Lee K, Balaj L, Passaro C, Rooj AK, Krasemann S, Carter BS, Chen CC, Steed T, Treiber J, Rodig S, Yang K, Nakano I, Lee H, Weissleder R, Breakefield XO, Godlewski J, Westphal M, Lamszus K, Freeman GJ, Bronisz A, Lawler SE, Chiocca EA
Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles.
Sci Adv. 2018;4(3):eaar2766 - PMID: 29532035 - PMCID: PMC5842038 - DOI: 10.1126/sciadv.aar2766
Lin HY, Yang KS, Curley C, Lee H, Welch MW, Wolpin BM, Weissleder R, Im H, Castro C
Bead Enhancement of EV Analysis
bioRxiv. 2018;:ePub - DOI: 10.1101/269423
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