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Qin T, Mattox AK, Campbell JS, Park JC, Shin KY, Li S, Sadow PM, Faquin WC, Micevic G, Daniels AJ, Haddad R, Garris CS, Pittet MJ, Mempel TR, ONeill A, Sartor MA, Pai SI

Epigenetic therapy sensitizes anti-PD-1 refractory head and neck cancers to immunotherapy rechallenge.
J Clin Invest. 2025;135(6):ePub - PMID: 40091844 - PMCID: PMC11910227 - DOI: 10.1172/JCI181671

Sun Y, Revach OY, Anderson S, Kessler EA, Wolfe CH, Jenney A, Mills CE, Robitschek EJ, Davis TGR, Kim S, Fu A, Ma X, Gwee J, Tiwari P, Du PP, Sindurakar P, Tian J, Mehta A, Schneider AM, Yizhak K, Sade-Feldman M, LaSalle T, Sharova T, Xie H, Liu S, Michaud WA, Saad-Beretta R, Yates KB, Iracheta-Vellve A, Spetz JKE, Qin X, Sarosiek KA, Zhang G, Kim JW, Su MY, Cicerchia AM, Rasmussen MQ, Klempner SJ, Juric D, Pai SI, Miller DM, Giobbie-Hurder A, Chen JH, Pelka K, Frederick DT, Stinson S, Ivanova E, Aref AR, Paweletz CP, Barbie DA, Sen DR, Fisher DE, Corcoran RB, Hacohen N, Sorger PK, Flaherty KT, Boland GM, Manguso RT, Jenkins RW

Targeting TBK1 to overcome resistance to cancer immunotherapy.
Nature. 2023;615(7950):158-167 - PMID: 36634707 - PMCID: PMC10171827 - DOI: 10.1038/s41586-023-05704-6

Bill R, Wirapati P, Messemaker M, Roh W, Zitti B, Duval F, Kiss M, Park JC, Saal TM, Hoelzl J, Tarussio D, Benedetti F, Tissot S, Kandalaft L, Varrone M, Ciriello G, McKee TA, Monnier Y, Mermod M, Blaum EM, Gushterova I, Gonye ALK, Hacohen N, Getz G, Mempel TR, Klein AM, Weissleder R, Faquin WC, Sadow PM, Lin D, Pai SI, Sade-Feldman M, Pittet MJ

CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers.
Science. 2023;381(6657):515-524 - PMID: 37535729 - PMCID: PMC10755760 - DOI: 10.1126/science.ade2292

Pai SI, Matheus HR, Guastaldi FPS

Effects of periodontitis on cancer outcomes in the era of immunotherapy.
Lancet Healthy Longev. 2023;4(4):e166-e175 - PMID: 37003275 - PMCID: PMC10148268 - DOI: 10.1016/S2666-7568(23)00021-1

Clifton GT, Rothenberg M, Ascierto PA, Begley G, Cecchini M, Eder JP, Ghiringhelli F, Italiano A, Kochetkova M, Li R, Mechta-Grigoriou F, Pai SI, Provenzano P, Puré E, Ribas A, Schalper KA, Fridman WH

Developing a definition of immune exclusion in cancer: results of a modified Delphi workshop.
J Immunother Cancer. 2023;11(6):ePub - PMID: 37290925 - PMCID: PMC10254706 - DOI: 10.1136/jitc-2023-006773

Pai SI, Wasserman I, Ji YD, Gilman M, Hung YP, Faquin WC, Mino-Kenudson M, Muniappan A

Pulmonary manifestations of chronic HPV infection in patients with recurrent respiratory papillomatosis
Lancet Respir Med. 2022;10(10):997-1008 - PMID: 35863360 - PMCID: PMC10634185 - DOI: 10.1016/S2213-2600(22)00008-X

Park BJ, Mattox AK, Clayburgh D, Patel M, Bell RB, Yueh B, Leidner R, Xiao H, Couey M, Li S, Qin T, Sartor MA, Cairns B, MacDonough T, Halliwill K, Deschler D, Lin DT, Faquin WC, Sadow PM, Pai SI

Chemoradiation therapy alters the PD-L1 score in locoregional recurrent squamous cell carcinomas of the head and neck.
Oral Oncol. 2022;135:106183 - PMID: 36215771 - PMCID: PMC10283355 - DOI: 10.1016/j.oraloncology.2022.106183

Oh J, Yoo TY, Saal TM, Tsay L, Faquin WC, Carlson JCT, Deschler DG, Pai SI, Weissleder R

Multiplexed single-cell analysis of FNA allows accurate diagnosis of salivary gland tumors.
Cancer Cytopathol. 2022;130(8):581-594 - PMID: 35666645 - PMCID: PMC9542730 - DOI: 10.1002/cncy.22594

Quintana JM, Arboleda D, Hu H, Scott E, Luthria G, Pai S, Parangi S, Weissleder R, Miller MA

Radiation Cleaved Drug-Conjugate Linkers Enable Local Payload Release.
Bioconjug Chem. 2022;33(8):1474-1484 - PMID: 35833631 - PMCID: PMC9390333 - DOI: 10.1021/acs.bioconjchem.2c00174

Oh J, Carlson JCT, Landeros C, Lee H, Ferguson S, Faquin WC, Clark JR, Pittet MJ, Pai SI, Weissleder R

Rapid serial immunoprofiling of the tumor immune microenvironment by fine needle sampling
Clin Cancer Res. 2021;27(17):4781-4793 - PMID: 34233961 - PMCID: PMC8416923 - DOI: 10.1158/1078-0432.CCR-21-1252

Siwicki M, Gort-Freitas NA, Messemaker M, Bill R, Gungabeesoon J, Engblom C, Zilionis R, Garris C, Gerhard GM, Kohl A, Lin Y, Zou AE, Cianciaruso C, Bolli E, Pfirschke C, Lin YJ, Piot C, Mindur JE, Talele N, Kohler RH, Iwamoto Y, Mino-Kenudson M, Pai SI, deVito C, Koessler T, Merkler D, Coukos A, Wicky A, Fraga M, Sempoux C, Jain RK, Dietrich PY, Michielin O, Weissleder R, Klein AM, Pittet MJ

Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy.
Sci Immunol. 2021;6(61):eabi7083 - PMID: 34215680 - PMCID: PMC8845079 - DOI: 10.1126/sciimmunol.abi7083

Mattox AK, Roelands J, Saal TM, Cheng Y, Rinchai D, Hendrickx W, Young GD, Diefenbach TJ, Berger AE, Westra WH, Bishop JA, Faquin WC, Marincola FM, Pittet MJ, Bedognetti D, Pai SI

Myeloid cells are enriched in tonsillar crypts providing insight into the host tropism of HPV.
Am J Pathol. 2021;191(10):1774-1786 - PMID: 34303699 - PMCID: PMC8491092 - DOI: 10.1016/j.ajpath.2021.06.012

Monteiro JLGC, Takusagawa T, Vasconcelos BCE, Pai SI, McCain JP, Guastaldi FPS

A rabbit model to investigate temporomandibular joint osteochondral regeneration.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2021;134(1):20-27 - PMID: 35165066 - DOI: 10.1016/j.oooo.2021.12.004

Bill R, Deschler DG, Pittet MJ, Pai SI, Sadow PM, Park JC

Diagnostic challenges and successful organ-preserving therapy in a case of secretory carcinoma of minor salivary glands.
Cancer Rep (Hoboken). 2021;5(3):e1491 - PMID: 34231337 - PMCID: PMC8955062 - DOI: 10.1002/cnr2.1491

Millar DG, Ramjiawan RR, Kawaguchi K, Gupta N, Chen J, Zhang S, Nojiri T, Ho WW, Aoki S, Jung K, Chen I, Shi F, Heather JM, Shigeta K, Morton LT, Sepulveda S, Wan L, Joseph R, Minogue E, Khatri A, Bardia A, Ellisen LW, Corcoran RB, Hata AN, Pai SI, Jain RK, Fukumura D, Duda DG, Cobbold M

Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy.
Nat Biotechnol. 2020;38(4):420-425 - PMID: 32042168 - PMCID: PMC7456461 - DOI: 10.1038/s41587-019-0404-8

Gastman B, Agarwal PK, Berger A, Boland G, Broderick S, Butterfield LH, Byrd D, Fecci PE, Ferris RL, Fong Y, Goff SL, Grabowski MM, Ito F, Lim M, Lotze MT, Mahdi H, Malafa M, Morris CD, Murthy P, Neves RI, Odunsi A, Pai SI, Prabhakaran S, Rosenberg SA, Saoud R, Sethuraman J, Skitzki J, Slingluff CL, Sondak VK, Sunwoo JB, Turcotte S, Yeung CC, Kaufman HL

Defining best practices for tissue procurement in immuno-oncology clinical trials: consensus statement from the Society for Immunotherapy of Cancer Surgery Committee.
J Immunother Cancer. 2020;8(2):ePub - PMID: 33199512 - PMCID: PMC7670953 - DOI: 10.1136/jitc-2020-001583

Mahmood U, Bang A, Chen YH, Mak RH, Lorch JH, Hanna GJ, Nishino M, Manuszak C, Thrash EM, Severgnini M, Sanborn M, Sridharan V, Margalit DN, Tishler RB, Busse PM, Willers H, Mamon HJ, Yoo HJ, Pai SI, Wirth LJ, Haddad RI, Chau NG, Schoenfeld JD

A Randomized Phase 2 Study of Pembrolizumab With or Without Radiation in Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma.
Int J Radiat Oncol Biol Phys. 2020;109(1):134-144 - PMID: 32781104 - PMCID: PMC9361179 - DOI: 10.1016/j.ijrobp.2020.08.018

Pai SI, Faquin WC, Sadow PM, Pittet MJ, Weissleder R

New Technology on the Horizon: Fast Analytical Screening Technique FNA (FAST-FNA) Enables Rapid, Multiplex Biomarker Analysis in Head and Neck Cancers
Cancer Cytopathol. 2020;128(11):782-791 - PMID: 32841527 - PMCID: PMC8276888 - DOI: 10.1002/cncy.22305

Wolkow N, Jakobiec FA, Afrogheh AH, Pai SI, Faquin WC

High Expression of Programmed Death Ligand 1 and Programmed Death Ligand 2 in Ophthalmic Sebaceous Carcinoma: The Case for a Clinical Trial of Checkpoint Inhibitors.
Am J Ophthalmol. 2020;220:128-139 - PMID: 32730911 - PMCID: PMC9361189 - DOI: 10.1016/j.ajo.2020.07.031

Wolkow N, Jakobiec FA, Afrogheh AH, Kidd M, Eagle RC, Pai SI, Faquin WC

PD-L1 and PD-L2 Expression Levels Are Low in Primary and Secondary Adenoid Cystic Carcinomas of the Orbit: Therapeutic Implications.
Ophthalmic Plast Reconstr Surg. 2020;36(5):444-450 - PMID: 31990894 - PMCID: PMC7423458 - DOI: 10.1097/IOP.0000000000001585

Pai SI, Cesano A, Marincola FM

The Paradox of Cancer Immune Exclusion: Immune Oncology Next Frontier.
Cancer Treat Res. 2020;180:173-195 - PMID: 32215870 - PMCID: PMC7423459 - DOI: 10.1007/978-3-030-38862-1_6

Pai SI, Marincola FM

Peripheral Circulating CD45RA-FOXP3hi T Regulatory (TReg) II Cells Provide a Window into the Activity of Intratumoral TReg Cells.
Trends Cancer. 2019;6(1):3-6 - PMID: 31952778 - PMCID: PMC7390988 - DOI: 10.1016/j.trecan.2019.11.003

Pai SI, Faivre S, Licitra L, Machiels JP, Vermorken JB, Bruzzi P, Gruenwald V, Giglio RE, Leemans CR, Seiwert TY, Soulieres D

Comparative analysis of the phase III clinical trials of anti-PD1 monotherapy in head and neck squamous cell carcinoma patients (CheckMate 141 and KEYNOTE 040).
J Immunother Cancer. 2019;7(1):96 - PMID: 30944020 - PMCID: PMC6446400 - DOI: 10.1186/s40425-019-0578-0

Wolkow N, Jakobiec FA, Afrogheh AH, Eagle RC, Pai SI, Faquin WC

Programmed Cell Death 1 Ligand 1 and Programmed Cell Death 1 Ligand 2 Are Expressed in Conjunctival Invasive Squamous Cell Carcinoma: Therapeutic Implications.
Am J Ophthalmol. 2019;200:226-241 - PMID: 30633894 - PMCID: PMC7456462 - DOI: 10.1016/j.ajo.2018.12.020

Ishida E, Lee J, Campbell JS, Chakravarty PD, Katori Y, Ogawa T, Johnson L, Mukhopadhyay A, Faquin WC, Lin DT, Wirth LJ, Pierce RH, Pai SI

Intratumoral delivery of an HPV vaccine elicits a broad anti-tumor immune response that translates into a potent anti-tumor effect in a preclinical murine HPV model.
Cancer Immunol Immunother. 2019;68(8):1273-1286 - PMID: 31243491 - PMCID: PMC6684362 - DOI: 10.1007/s00262-019-02357-1

Pai SI, Cohen EEW, Lin D, Fountzilas G, Kim ES, Mehlhorn H, Baste N, Clayburgh D, Lipworth L, Resteghini C, Shara N, Fujii T, Zhang J, Stokes M, Wang H, Twumasi-Ankrah P, Wildsmith S, Khaliq A, Melillo G, Shire N

SUPREME-HN: a retrospective biomarker study assessing the prognostic value of PD-L1 expression in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck.
J Transl Med. 2019;17(1):429 - PMID: 31878938 - PMCID: PMC6933901 - DOI: 10.1186/s12967-019-02182-1

Banik G, Betts CB, Liudahl SM, Sivagnanam S, Kawashima R, Cotechini T, Larson W, Goecks J, Pai SI, Clayburgh DR, Tsujikawa T, Coussens LM

High-dimensional multiplexed immunohistochemical characterization of immune contexture in human cancers.
Methods Enzymol. 2019;635:1-20 - PMID: 32122539 - PMCID: PMC7390987 - DOI: 10.1016/bs.mie.2019.05.039

Garris CS*, Arlauckas SP*, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12
Immunity. 2018;49:1-14 - PMID: 30552023 - PMCID: PMC6301092 - DOI: 10.1016/j.immuni.2018.09.024

Kartha VK, Alamoud KA, Sadykov K, Nguyen BC, Laroche F, Feng H, Lee J, Pai SI, Varelas X, Egloff AM, Snyder-Cappione JE, Belkina AC, Bais MV, Monti S, Kukuruzinska MA

Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer.
Genome Med. 2018;10(1):54 - PMID: 30029671 - PMCID: PMC6053793 - DOI: 10.1186/s13073-018-0569-7

Rosenbaum MW, Gigliotti BJ, Pai SI, Parangi S, Wachtel H, Mino-Kenudson M, Gunda V, Faquin WC

PD-L1 and IDO1 Are Expressed in Poorly Differentiated Thyroid Carcinoma.
Endocr Pathol. 2018;29(1):59-67 - PMID: 29372535 - PMCID: PMC6500591 - DOI: 10.1007/s12022-018-9514-y

Mattox AK, Lee J, Westra WH, Pierce RH, Ghossein R, Faquin WC, Diefenbach TJ, Morris LG, Lin DT, Wirth LJ, Lefranc-Torres A, Ishida E, Chakravarty PD, Johnson L, Zeng YC, Chen H, Poznansky MC, Iyengar NM, Pai SI

PD-1 Expression in Head and Neck Squamous Cell Carcinomas Derives Primarily from Functionally Anergic CD4+ TILs in the Presence of PD-L1+ TAMs.
Cancer Res. 2017;77(22):6365-6374 - PMID: 28947422 - PMCID: PMC5690870 - DOI: 10.1158/0008-5472.CAN-16-3453

Pai SI, Jack Lee J, Carey TE, Westra WH, Ferrone S, Moore C, Mosunjac MB, Shin DM, Ferris RL, HNC SPORE HIV supplement consortium

HLA class I antigen processing machinery (APM) component expression and PD-1:PD-L1 pathway activation in HIV-infected head and neck cancers.
Oral Oncol. 2017;77:92-97 - PMID: 29362132 - PMCID: PMC5786382 - DOI: 10.1016/j.oraloncology.2017.12.014

Pai SI, Faquin WC

Programmed cell death ligand 1 as a biomarker in head and neck cancer.
Cancer Cytopathol. 2017;125(7):529-533 - PMID: 28472542 - PMCID: PMC5690557 - DOI: 10.1002/cncy.21872

Pai SI, Wirth LJ

Checkpoint cluster: biomarkers of response.
Emerg Top Life Sci. 2017;1(5):501-508 - PMID: 33525795 - DOI: 10.1042/ETLS20170077

Zhang H, Kim S, Chen Z, Nannapaneni S, Chen AY, Moore CE, Sica G, Mosunjac M, Nguyen MLT, D'Souza G, Carey TE, Peterson LA, McHugh JB, Graham M, Komarck CM, Wolf GT, Walline HM, Bellile E, Riddell J, Pai SI, Sidransky D, Westra WH, William WN, Lee JJ, El-Naggar AK, Ferris RL, Seethala R, Grandis JR, Chen ZG, Saba NF, Shin DM, Head and Neck Cancer SPORE HIV supplement consortium

Prognostic biomarkers in patients with human immunodeficiency virus-positive disease with head and neck squamous cell carcinoma.
Head Neck. 2017;39(12):2433-2443 - PMID: 28945296 - PMCID: PMC5808949 - DOI: 10.1002/hed.24911

Gleber-Netto FO, Zhao M, Trivedi S, Wang J, Jasser S, McDowell C, Kadara H, Zhang J, Wang J, William WN, Lee JJ, Nguyen ML, Pai SI, Walline HM, Shin DM, Ferris RL, Carey TE, Myers JN, Pickering CR, Head and Neck Cancer Specialized Program of Research Excellence (SPORE) Human Immunodeficiency Virus (HIV) Supplement Consortium

Distinct pattern of TP53 mutations in human immunodeficiency virus-related head and neck squamous cell carcinoma.
Cancer. 2017;124(1):84-94 - PMID: 29053175 - PMCID: PMC5785080 - DOI: 10.1002/cncr.31063

Mohan S, Pai SI, Bhattacharyya N

Adjuvant radiotherapy is not supported in patients with verrucous carcinoma of the oral cavity.
Laryngoscope. 2017;127(6):1334-1338 - PMID: 28150306 - PMCID: PMC7388729 - DOI: 10.1002/lary.26443

Brotherton JM, Jit M, Gravitt PE, Brisson M, Kreimer AR, Pai SI, Fakhry C, Monsonego J, Franceschi S

Eurogin Roadmap 2015: How has HPV knowledge changed our practice: Vaccines.
Int J Cancer. 2016;139(3):510-7 - PMID: 26916230 - PMCID: PMC7388730 - DOI: 10.1002/ijc.30063

Pai SI, Zandberg DP, Strome SE

The role of antagonists of the PD-1:PD-L1/PD-L2 axis in head and neck cancer treatment.
Oral Oncol. 2016;61:152-8 - PMID: 27503244 - PMCID: PMC5690560 - DOI: 10.1016/j.oraloncology.2016.08.001

Walline HM, Carey TE, Goudsmit CM, Bellile EL, D'Souza G, Peterson LA, McHugh JB, Pai SI, Lee JJ, Shin DM, Ferris RL, HNC SPORE HIV supplement consortium

High-Risk HPV, Biomarkers, and Outcome in Matched Cohorts of Head and Neck Cancer Patients Positive and Negative for HIV.
Mol Cancer Res. 2016;15(2):179-188 - PMID: 27899422 - PMCID: PMC5290187 - DOI: 10.1158/1541-7786.MCR-16-0255

Peng S, Mattox A, Best SR, Barbu AM, Burns JA, Akpeng B, Jeang J, Yang B, Ishida E, Hung CF, Wu TC, Pai SI

Identification of the murine H-2D(b) and human HLA-A*0201 MHC class I-restricted HPV6 E7-specific cytotoxic T lymphocyte epitopes.
Cancer Immunol Immunother. 2016;65(3):261-71 - PMID: 26759151 - PMCID: PMC5690558 - DOI: 10.1007/s00262-016-1793-x

Anderson KS, Gerber JE, D'Souza G, Pai SI, Cheng JN, Alam R, Kesiraju S, Chowell D, Gross ND, Haddad R, Gillison ML, Posner M

Biologic predictors of serologic responses to HPV in oropharyngeal cancer: The HOTSPOT study.
Oral Oncol. 2015;51(8):751-8 - PMID: 26094591 - PMCID: PMC4982366 - DOI: 10.1016/j.oraloncology.2015.05.007

Peng S, Wang JW, Karanam B, Wang C, Huh WK, Alvarez RD, Pai SI, Hung CF, Wu TC, Roden RB

Sequential cisplatin therapy and vaccination with HPV16 E6E7L2 fusion protein in saponin adjuvant GPI-0100 for the treatment of a model HPV16+ cancer.
PLoS ONE. 2015;10(1):e116389 - PMID: 25560237 - PMCID: PMC4283968 - DOI: 10.1371/journal.pone.0116389

Pierce RH, Campbell JS, Pai SI, Brody JD, Kohrt HE

In-situ tumor vaccination: Bringing the fight to the tumor.
Hum Vaccin Immunother. 2015;11(8):1901-9 - PMID: 26055074 - PMCID: PMC4635874 - DOI: 10.1080/21645515.2015.1049779

D'Souza G, Gross ND, Pai SI, Haddad R, Anderson KS, Rajan S, Gerber J, Gillison ML, Posner MR

Oral human papillomavirus (HPV) infection in HPV-positive patients with oropharyngeal cancer and their partners.
J Clin Oncol. 2014;32(23):2408-15 - PMID: 24778397 - PMCID: PMC4263818 - DOI: 10.1200/JCO.2014.55.1341

Aragon Han P, Olson MT, Fazeli R, Prescott JD, Pai SI, Schneider EB, Tufano RP, Zeiger MA

The impact of molecular testing on the surgical management of patients with thyroid nodules.
Ann Surg Oncol. 2014;21(6):1862-9 - PMID: 24522987 - DOI: 10.1245/s10434-014-3508-x

Smith DF, Maleki Z, Coughlan D, Gooi Z, Akpeng B, Ogawa T, Bishop JA, Frick KD, Agrawal N, Gourin CG, Ha PK, Koch WM, Richmon JD, Westra WH, Pai SI

Human papillomavirus status of head and neck cancer as determined in cytologic specimens using the hybrid-capture 2 assay.
Oral Oncol. 2014;50(6):600-4 - PMID: 24630260 - PMCID: PMC4318229 - DOI: 10.1016/j.oraloncology.2014.02.011

Marcus C, Whitworth PW, Surasi DS, Pai SI, Subramaniam RM

PET/CT in the management of thyroid cancers.
AJR Am J Roentgenol. 2014;202(6):1316-29 - PMID: 24848831 - DOI: 10.2214/AJR.13.11673

Dʼsouza G, Carey TE, William WN, Nguyen ML, Ko EC, Riddell J, Pai SI, Gupta V, Walline HM, Lee JJ, Wolf GT, Shin DM, Grandis JR, Ferris RL

Epidemiology of head and neck squamous cell cancer among HIV-infected patients.
J Acquir Immune Defic Syndr. 2014;65(5):603-10 - PMID: 24326607 - PMCID: PMC3999230 - DOI: 10.1097/QAI.0000000000000083

Ahn J, Bishop JA, Akpeng B, Pai SI, Best SR

Xenograft model for therapeutic drug testing in recurrent respiratory papillomatosis.
Ann Otol Rhinol Laryngol. 2014;124(2):110-5 - PMID: 25124839 - PMCID: PMC7423457 - DOI: 10.1177/0003489414546400

Gooi Z, Ward BK, Mener DJ, Ozgursoy OB, Pai SI

A staged thyroidectomy approach for gastric bypass patients.
Laryngoscope. 2014;125(4):1028-30 - PMID: 25043176 - DOI: 10.1002/lary.24835

Xing M, Alzahrani AS, Carson KA, Viola D, Elisei R, Bendlova B, Yip L, Mian C, Vianello F, Tuttle RM, Robenshtok E, Fagin JA, Puxeddu E, Fugazzola L, Czarniecka A, Jarzab B, O'Neill CJ, Sywak MS, Lam AK, Riesco-Eizaguirre G, Santisteban P, Nakayama H, Tufano RP, Pai SI, Zeiger MA, Westra WH, Clark DP, Clifton-Bligh R, Sidransky D, Ladenson PW, Sykorova V

Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer.
JAMA. 2013;309(14):1493-501 - PMID: 23571588 - PMCID: PMC3791140 - DOI: 10.1001/jama.2013.3190

Lyford-Pike S, Peng S, Young GD, Taube JM, Westra WH, Akpeng B, Bruno TC, Richmon JD, Wang H, Bishop JA, Chen L, Drake CG, Topalian SL, Pardoll DM, Pai SI

Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma.
Cancer Res. 2013;73(6):1733-41 - PMID: 23288508 - PMCID: PMC3602406 - DOI: 10.1158/0008-5472.CAN-12-2384

Wu CY, Yang LH, Yang HY, Knoff J, Peng S, Lin YH, Wang C, Alvarez RD, Pai SI, Roden RB, Hung CF, Wu TC

Enhanced cancer radiotherapy through immunosuppressive stromal cell destruction in tumors.
Clin Cancer Res. 2013;20(3):644-57 - PMID: 24300786 - PMCID: PMC3946442 - DOI: 10.1158/1078-0432.CCR-13-1334

Pai SI

Mission impossible: how HPV-associated head and neck cancers escape a primed immune response.
Oral Oncol. 2013;49(8):723-5 - PMID: 23643070 - DOI: 10.1016/j.oraloncology.2013.03.453

Bishop JA, Ogawa T, Stelow EB, Moskaluk CA, Koch WM, Pai SI, Westra WH

Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract.
Am J Surg Pathol. 2013;37(6):836-44 - PMID: 23598962 - PMCID: PMC3653997 - DOI: 10.1097/PAS.0b013e31827b1cd6

Jara SM, Carson KA, Pai SI, Agrawal N, Richmon JD, Prescott JD, Dackiw A, Zeiger MA, Bishop JA, Tufano RP

The relationship between chronic lymphocytic thyroiditis and central neck lymph node metastasis in North American patients with papillary thyroid carcinoma.
Surgery. 2013;154(6):1272-80; discussion 1280-2 - PMID: 24238047 - DOI: 10.1016/j.surg.2013.07.021

Lin BM, Wang H, D'Souza G, Zhang Z, Fakhry C, Joseph AW, Drake VE, Sanguineti G, Westra WH, Pai SI

Long-term prognosis and risk factors among patients with HPV-associated oropharyngeal squamous cell carcinoma.
Cancer. 2013;119(19):3462-71 - PMID: 23861037 - PMCID: PMC3788050 - DOI: 10.1002/cncr.28250

Pai SI

Adaptive immune resistance in HPV-associated head and neck squamous cell carcinoma.
OncoImmunology. 2013;2(5):e24065 - PMID: 23762795 - PMCID: PMC3667901 - DOI: 10.4161/onci.24065

Bishop JA, Guo TW, Smith DF, Wang H, Ogawa T, Pai SI, Westra WH

Human papillomavirus-related carcinomas of the sinonasal tract.
Am J Surg Pathol. 2013;37(2):185-92 - PMID: 23095507 - PMCID: PMC3545097 - DOI: 10.1097/PAS.0b013e3182698673

Fan KY, Gogineni H, Zaboli D, Lake S, Zahurak ML, Best SR, Levine MA, Tang M, Zinreich ES, Saunders JR, Califano JA, Blanco RG, Pai SI, Messing B, Ha PK

Comparison of acute toxicities in two primary chemoradiation regimens in the treatment of advanced head and neck squamous cell carcinoma.
Ann Surg Oncol. 2012;19(6):1980-7 - PMID: 22290566 - PMCID: PMC3715048 - DOI: 10.1245/s10434-012-2219-4

Joseph AW, Ogawa T, Bishop JA, Lyford-Pike S, Chang X, Phelps TH, Westra WH, Pai SI

Molecular etiology of second primary tumors in contralateral tonsils of human papillomavirus-associated index tonsillar carcinomas.
Oral Oncol. 2012;49(3):244-8 - PMID: 23062994 - PMCID: PMC3548989 - DOI: 10.1016/j.oraloncology.2012.09.009

Teixeira GV, Chikota H, Teixeira T, Manfro G, Pai SI, Tufano RP

Incidence of malignancy in thyroid nodules determined to be follicular lesions of undetermined significance on fine-needle aspiration.
World J Surg. 2012;36(1):69-74 - PMID: 22057754 - DOI: 10.1007/s00268-011-1336-8

Bishop JA, Ogawa T, Chang X, Illei PB, Gabrielson E, Pai SI, Westra WH

HPV analysis in distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma.
Am J Surg Pathol. 2012;36(1):142-8 - PMID: 22173119 - PMCID: PMC3273906 - DOI: 10.1097/PAS.0b013e3182395c7b

Peng S, Lyford-Pike S, Akpeng B, Wu A, Hung CF, Hannaman D, Saunders JR, Wu TC, Pai SI

Low-dose cyclophosphamide administered as daily or single dose enhances the antitumor effects of a therapeutic HPV vaccine.
Cancer Immunol Immunother. 2012;62(1):171-82 - PMID: 23011589 - PMCID: PMC3543472 - DOI: 10.1007/s00262-012-1322-5

Best SR, Niparko KJ, Pai SI

Biology of human papillomavirus infection and immune therapy for HPV-related head and neck cancers.
Otolaryngol Clin North Am. 2012;45(4):807-22 - PMID: 22793854 - PMCID: PMC3398423 - DOI: 10.1016/j.otc.2012.04.005

Pai SI

HPV-associated head and neck cancers.
Otolaryngol Clin North Am. 2012;45(4):xi-xii - PMID: 22793861 - DOI: 10.1016/j.otc.2012.05.003

Bishop JA, Maleki Z, Valsamakis A, Ogawa T, Chang X, Pai SI, Westra WH

Application of the hybrid capture 2 assay to squamous cell carcinomas of the head and neck: a convenient liquid-phase approach for the reliable determination of human papillomavirus status.
Cancer Cytopathol. 2011;120(1):18-25 - PMID: 21751428 - PMCID: PMC3197962 - DOI: 10.1002/cncy.20175

Gomez NR, Kouniavsky G, Tsai HL, Somervell H, Pai SI, Tufano RP, Umbricht C, Kowalski J, Dackiw AP, Zeiger MA

Tumor size and presence of calcifications on ultrasonography are pre-operative predictors of lymph node metastases in patients with papillary thyroid cancer.
J Surg Oncol. 2011;104(6):613-6 - PMID: 21744345 - DOI: 10.1002/jso.21891

Wu G, Fraser S, Pai SI, Farrag TY, Ladenson PW, Tufano RP

Determining the extent of lateral neck dissection necessary to establish regional disease control and avoid reoperation after previous total thyroidectomy and radioactive iodine for papillary thyroid cancer.
Head Neck. 2011;34(10):1418-21 - PMID: 22052539 - DOI: 10.1002/hed.21937

Best SR, Ha PK, Blanco RG, Saunders JR, Zinreich ES, Levine MA, Pai SI, Walker M, Trachta J, Ulmer K, Murakami P, Thompson R, Califano JA, Messing BP

Factors associated with pharyngoesophageal stricture in patients treated with concurrent chemotherapy and radiation therapy for oropharyngeal squamous cell carcinoma.
Head Neck. 2011;33(12):1727-34 - PMID: 21246640 - PMCID: PMC4695991 - DOI: 10.1002/hed.21657

Park IS, Chang X, Loyo M, Wu G, Chuang A, Kim MS, Chae YK, Lyford-Pike S, Westra WH, Saunders JR, Sidransky D, Pai SI

Characterization of the methylation patterns in human papillomavirus type 16 viral DNA in head and neck cancers.
Cancer Prev Res (Phila). 2011;4(2):207-17 - PMID: 21292634 - PMCID: PMC3079312 - DOI: 10.1158/1940-6207.CAPR-10-0147

Anderson KS, Wong J, D'Souza G, Riemer AB, Lorch J, Haddad R, Pai SI, Longtine J, McClean M, LaBaer J, Kelsey KT, Posner M

Serum antibodies to the HPV16 proteome as biomarkers for head and neck cancer.
Br J Cancer. 2011;104(12):1896-905 - PMID: 21654689 - PMCID: PMC3111202 - DOI: 10.1038/bjc.2011.171

Cho YG, Chang X, Park IS, Yamashita K, Shao C, Ha PK, Pai SI, Sidransky D, Kim MS

Promoter methylation of leukemia inhibitory factor receptor gene in colorectal carcinoma.
Int J Oncol. 2011;39(2):337-44 - PMID: 21617854 - PMCID: PMC3601031 - DOI: 10.3892/ijo.2011.1050

Wu G, Pai SI, Agrawal N, Richmon J, Dackiw A, Tufano RP

Profile of patients with completion thyroidectomy and assessment of their suitability for outpatient surgery.
Otolaryngol Head Neck Surg. 2011;145(5):727-31 - PMID: 21860058 - DOI: 10.1177/0194599811416749

Kang TH, Noh KH, Kim JH, Bae HC, Lin KY, Monie A, Pai SI, Hung CF, Wu TC, Kim TW

Ectopic expression of X-linked lymphocyte-regulated protein pM1 renders tumor cells resistant to antitumor immunity.
Cancer Res. 2010;70(8):3062-70 - PMID: 20395201 - PMCID: PMC2861497 - DOI: 10.1158/0008-5472.CAN-09-3856

Wu A, Zeng Q, Kang TH, Peng S, Roosinovich E, Pai SI, Hung CF

Innovative DNA vaccine for human papillomavirus (HPV)-associated head and neck cancer.
Gene Ther. 2010;18(3):304-12 - PMID: 20981112 - PMCID: PMC3032008 - DOI: 10.1038/gt.2010.151

Kim D, Hoory T, Monie A, Wu A, Hsueh WT, Pai SI, Hung CF

Delivery of chemotherapeutic agents using drug-loaded irradiated tumor cells to treat murine ovarian tumors.
J Biomed Sci. 2010;17:61 - PMID: 20659328 - PMCID: PMC2918546 - DOI: 10.1186/1423-0127-17-61

Peng S, Best SR, Hung CF, Loyo M, Lyford-Pike S, Flint PW, Tunkel DE, Saunders JR, Wu TC, Pai SI

Characterization of human papillomavirus type 11-specific immune responses in a preclinical model.
Laryngoscope. 2010;120(3):504-10 - PMID: 20025042 - PMCID: PMC2908018 - DOI: 10.1002/lary.20745

Lyford-Pike S, Westra WH, Loyo M, Peng S, Hung CF, Wu AA, Flint PW, Tunkel DE, Saunders JR, Pai SI

Differential expression of epidermal growth factor receptor in juvenile and adult-onset recurrent respiratory papillomatosis.
Histopathology. 2010;57(5):768-70 - PMID: 21083608 - DOI: 10.1111/j.1365-2559.2010.03691.x

Tufano RP, Pai SI

Thyroid and parathyroid surgery. Preface.
Otolaryngol Clin North Am. 2010;43(2):xiii-xiv - PMID: 20510709 - DOI: 10.1016/j.otc.2010.04.001

Pai SI, Tufano RP

Reoperation for recurrent/persistent well-differentiated thyroid cancer.
Otolaryngol Clin North Am. 2010;43(2):353-63, ix - PMID: 20510718 - DOI: 10.1016/j.otc.2010.02.004

Pai SI, Westra WH

Molecular pathology of head and neck cancer: implications for diagnosis, prognosis, and treatment.
Annu Rev Pathol. 2009;4:49-70 - PMID: 18729723 - PMCID: PMC3703474 - DOI: 10.1146/annurev.pathol.4.110807.092158

Chuang CM, Monie A, Wu A, Pai SI, Hung CF

Combination of viral oncolysis and tumor-specific immunity to control established tumors.
Clin Cancer Res. 2009;15(14):4581-8 - PMID: 19584165 - PMCID: PMC3076709 - DOI: 10.1158/1078-0432.CCR-08-2685

Kang TH, Chung JY, Monie A, Pai SI, Hung CF, Wu TC

Enhancing DNA vaccine potency by co-administration of xenogenic MHC class-I DNA.
Gene Ther. 2009;17(4):531-40 - PMID: 19940864 - PMCID: PMC2851845 - DOI: 10.1038/gt.2009.152

Best SR, Peng S, Juang CM, Hung CF, Hannaman D, Saunders JR, Wu TC, Pai SI

Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery.
Vaccine. 2009;27(40):5450-9 - PMID: 19622402 - PMCID: PMC2745985 - DOI: 10.1016/j.vaccine.2009.07.005

Hillel AT, Fakhry C, Pai SI, Williams MF, Blanco RG, Zinreich ES, Levine MA, Westra WH, Saunders JR, Ha PK

Selective versus comprehensive neck dissection after chemoradiation for advanced oropharyngeal squamous cell carcinoma.
Otolaryngol Head Neck Surg. 2009;141(6):737-42 - PMID: 19932847 - DOI: 10.1016/j.otohns.2009.09.010

Sedaghat AR, Zhang Z, Begum S, Palermo R, Best S, Ulmer KM, Levine M, Zinreich E, Messing BP, Gold D, Wu AA, Niparko KJ, Kowalski J, Hirata RM, Saunders JR, Westra WH, Pai SI

Prognostic significance of human papillomavirus in oropharyngeal squamous cell carcinomas.
Laryngoscope. 2009;119(8):1542-9 - PMID: 19522004 - DOI: 10.1002/lary.20533

Tsen SW, Wu CY, Meneshian A, Pai SI, Hung CF, Wu TC

Femtosecond laser treatment enhances DNA transfection efficiency in vivo.
J Biomed Sci. 2009;16:36 - PMID: 19338665 - PMCID: PMC2669473 - DOI: 10.1186/1423-0127-16-36

Noh KH, Kang TH, Kim JH, Pai SI, Lin KY, Hung CF, Wu TC, Kim TW

Activation of Akt as a mechanism for tumor immune evasion.
Mol Ther. 2008;17(3):439-47 - PMID: 19107122 - PMCID: PMC2835083 - DOI: 10.1038/mt.2008.255

Goldenberg D, Begum S, Westra WH, Khan Z, Sciubba J, Pai SI, Califano JA, Tufano RP, Koch WM

Cystic lymph node metastasis in patients with head and neck cancer: An HPV-associated phenomenon.
Head Neck. 2008;30(7):898-903 - PMID: 18383529 - DOI: 10.1002/hed.20796

Loyo M, Pai SI, Netto GJ, Tunkel DE

Aggressive recurrent respiratory papillomatosis in a neonate.
Int J Pediatr Otorhinolaryngol. 2008;72(6):917-20 - PMID: 18423627 - DOI: 10.1016/j.ijporl.2008.02.022

Pai SI, Tufano RP

Central compartment neck dissection for thyroid cancer. Technical considerations.
ORL J Otorhinolaryngol Relat Spec. 2008;70(5):292-7 - PMID: 18971593 - DOI: 10.1159/000149831

Wu AA, Niparko KJ, Pai SI

Immunotherapy for head and neck cancer.
J Biomed Sci. 2008;15(3):275-89 - PMID: 18392689 - DOI: 10.1007/s11373-008-9247-x

Loyo M, Pai SI

The molecular genetics of laryngeal cancer.
Otolaryngol Clin North Am. 2008;41(4):657-72, v - PMID: 18570952 - DOI: 10.1016/j.otc.2008.01.019

Kang TH, Lee JH, Song CK, Han HD, Shin BC, Pai SI, Hung CF, Trimble C, Lim JS, Kim TW, Wu TC

Epigallocatechin-3-gallate enhances CD8+ T cell-mediated antitumor immunity induced by DNA vaccination.
Cancer Res. 2007;67(2):802-11 - PMID: 17234792 - PMCID: PMC3181129 - DOI: 10.1158/0008-5472.CAN-06-2638

Lin LM, Pai SI, Flint PW

A retropharyngeal pseudoabscess in a patient with paroxysmal nocturnal hemoglobinuria.
Otolaryngol Head Neck Surg. 2007;137(4):684-6 - PMID: 17903595 - DOI: 10.1016/j.otohns.2007.01.032

Pai SI, Lin YY, Macaes B, Meneshian A, Hung CF, Wu TC

Prospects of RNA interference therapy for cancer.
Gene Ther. 2006;13(6):464-77 - PMID: 16341059 - DOI: 10.1038/sj.gt.3302694

Pai SI, Goldstein BJ, Studeman KD, Westra WH, Tufano RP

Concurrent sporadic parathyroid adenoma and carcinoma.
Am J Otolaryngol. 2006;27(5):346-8 - PMID: 16935182 - DOI: 10.1016/j.amjoto.2005.11.017

Flint PW, Li ZB, Lehar M, Saito K, Pai SI

Laryngeal muscle surface receptors identified using random phage library.
Laryngoscope. 2005;115(11):1930-7 - PMID: 16319601 - DOI: 10.1097/01.mlg.0000172273.98418.8d

Kim JW, Hung CF, Juang J, He L, Kim TW, Armstrong DK, Pai SI, Chen PJ, Lin CT, Boyd DA, Wu TC

Comparison of HPV DNA vaccines employing intracellular targeting strategies.
Gene Ther. 2004;11(12):1011-8 - PMID: 14985791 - DOI: 10.1038/sj.gt.3302252

Kim TW, Hung CF, Zheng M, Boyd DA, He L, Pai SI, Wu TC

A DNA vaccine co-expressing antigen and an anti-apoptotic molecule further enhances the antigen-specific CD8+ T-cell immune response.
J Biomed Sci. 2004;11(4):493-9 - PMID: 15153784 - DOI: 10.1007/BF02256098

Pai SI, Limb CJ, Nicol T, Williams MF

Leiomyosarcoma of the auricle.
Otolaryngol Head Neck Surg. 2003;128(3):442-4 - PMID: 12646855 - DOI: 10.1067/mhn.2003.16

Ha PK, Pai SI, Westra WH, Gillison ML, Tong BC, Sidransky D, Califano JA

Real-time quantitative PCR demonstrates low prevalence of human papillomavirus type 16 in premalignant and malignant lesions of the oral cavity.
Clin Cancer Res. 2002;8(5):1203-9 - PMID: 12006539

Cheng WF, Hung CF, Pai SI, Hsu KF, He L, Ling M, Wu TC

Repeated DNA vaccinations elicited qualitatively different cytotoxic T lymphocytes and improved protective antitumor effects.
J Biomed Sci. 2002;9(6 Pt 2):675-87 - PMID: 12432234 - DOI: 10.1159/000067285

Dong SM, Pai SI, Rha SH, Hildesheim A, Kurman RJ, Schwartz PE, Mortel R, McGowan L, Greenberg MD, Barnes WA, Sidransky D

Detection and quantitation of human papillomavirus DNA in the plasma of patients with cervical carcinoma.
Cancer Epidemiol Biomarkers Prev. 2002;11(1):3-6 - PMID: 11815394

Tseng SY, Otsuji M, Gorski K, Huang X, Slansky JE, Pai SI, Shalabi A, Shin T, Pardoll DM, Tsuchiya H

B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells.
J Exp Med. 2001;193(7):839-46 - PMID: 11283156 - PMCID: PMC2193370 - DOI: 10.1084/jem.193.7.839

Capone RB, Pai SI, Koch WM, Gillison ML, Danish HN, Westra WH, Daniel R, Shah KV, Sidransky D

Detection and quantitation of human papillomavirus (HPV) DNA in the sera of patients with HPV-associated head and neck squamous cell carcinoma.
Clin Cancer Res. 2000;6(11):4171-5 - PMID: 11106228

Wang TL, Ling M, Shih IM, Pham T, Pai SI, Lu Z, Kurman RJ, Pardoll DM, Wu TC

Intramuscular administration of E7-transfected dendritic cells generates the most potent E7-specific anti-tumor immunity.
Gene Ther. 2000;7(9):726-33 - PMID: 10822298 - DOI: 10.1038/sj.gt.3301160

Ji H, Wang TL, Chen CH, Pai SI, Hung CF, Lin KY, Kurman RJ, Pardoll DM, Wu TC

Targeting human papillomavirus type 16 E7 to the endosomal/lysosomal compartment enhances the antitumor immunity of DNA vaccines against murine human papillomavirus type 16 E7-expressing tumors.
Hum Gene Ther. 1999;10(17):2727-40 - PMID: 10584920 - DOI: 10.1089/10430349950016474

Pai SI, Wu GS, Ozören N, Wu L, Jen J, Sidransky D, El-Deiry WS

Rare loss-of-function mutation of a death receptor gene in head and neck cancer.
Cancer Res. 1998;58(16):3513-8 - PMID: 9721851

Trink B, Pai SI, Spunt SL, Raman V, Cairns P, Jen J, Gabrielson E, Sukumar S, Sidransky D

Absence of TSG101 transcript abnormalities in human cancers.
Oncogene. 1998;16(21):2815-8 - PMID: 9652749 - DOI: 10.1038/sj.onc.1201795

Nichols RC, Blinder J, Pai SI, Ge Q, Targoff IN, Plotz PH, Liu P

Assignment of two human autoantigen genes-isoleucyl-tRNA synthetase locates to 9q21 and lysyl-tRNA synthetase locates to 16q23-q24.
Genomics. 1996;36(1):210-3 - PMID: 8812440 - DOI: 10.1006/geno.1996.0449

Nichols RC, Pai SI, Ge Q, Targoff IN, Plotz PH, Liu P

Localization of two human autoantigen genes by PCR screening and in situ hybridization--glycyl-tRNA synthetase locates to 7p15 and alanyl-tRNA synthetase locates to 16q22.
Genomics. 1995;30(1):131-2 - PMID: 8595897 - DOI: 10.1006/geno.1995.0028

Friedmann AS, Malott KA, Memoli VA, Pai SI, Yu XM, North WG

Products of vasopressin gene expression in small-cell carcinoma of the lung.
Br J Cancer. 1994;69(2):260-3 - PMID: 8297723 - PMCID: PMC1968694 - DOI: 10.1038/bjc.1994.49
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