About

Herbert Lin's Lab

Hepcidin

The overall theme of my laboratory is to understand the role of the TGF-β/BMP signaling pathways in health and disease. My laboratory has currently three major areas of interest: 1) Understanding the role of the RGM/DRAGON family of BMP co-receptors in the regulation of BMP signaling; 2) Determining the specific role of hemojuvelin (HJV) in the regulation of hepcidin expression and iron metabolism; 3) Study of TGF-β/BMP ligands interaction with receptors using biochemical and cell biology techniques. Ultimately, by studying this complex but important signaling system, we aim to generate new knowledge that will lead to novel therapeutic options for chronic diseases such as chronic kidney disease, hemochromatosis and anemia of chronic disease.

Recent Publications (more...)

Babitt JL, Lin HY
BuMPing iron with modified heparins.
Blood. 2014;123(10):1440-1 - PMID: 24627550 - PMCID: PMC3945857
Hilgendorf I, Theurl I, Gerhardt LM, Robbins CS, Weber GF, Gonen A, Iwamoto Y, Degousee N, Holderried TA, Winter C, Zirlik A, Lin HY, Sukhova GK, Butany J, Rubin BB, Witztum JL, Libby P, Nahrendorf M, Weissleder R, Swirski FK
Innate Response Activator B Cells Aggravate Atherosclerosis by Stimulating TH1 Adaptive Immunity.
Circulation. 2014;129(16):1677-87 - PMID: 24488984
Meynard D, Babitt JL, Lin HY
The liver: conductor of systemic iron regulation.
Blood. 2013;123(2):168-76 - PMID: 24200681 - PMCID: PMC3888285
Meynard D, Sun CC, Wu Q, Chen W, Chen S, Nelson CN, Waters MJ, Babitt JL, Lin HY
Inflammation Regulates TMPRSS6 Expression via STAT5.
PLoS ONE. 2013;8(12):e82127 - PMID: 24376517 - PMCID: PMC3871639

Recent News (more...)

2013-10-23: On October 1st, 2013 the Division of Nephrology announced that Dr. Herbert Y. Lin will assume the position of Director of Translational Research. Dr. Lin leads a highly productive laboratory within the Division of Nephrology and Center for Systems Biology focusing on TGF-β/BMP signaling pathways and is widely recognized for his mentorship of junior investigators.
2012-03-09: Jodie Babitt, MD, is the recipient of the 2012 MGH Howard Goodman Fellowship. This highly competitive $300,000 award is "intended to further the career of outstanding young scientists who have demonstrated the potential to rise to a leadership position in their chosen field". Jodie won this award for her pioneering bench-to-bedside work on the identification and development of novel regulators of body iron homeostasis. Congratulations Jodie.

Lin

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