Herbert Lin's Lab
The overall theme of my laboratory is to understand the role of the TGF-β/BMP signaling
pathways in health and disease. My laboratory has currently three major areas of
interest: 1) Understanding the role of the RGM/DRAGON family of BMP co-receptors
in the regulation of BMP signaling; 2) Determining the specific role of hemojuvelin
(HJV) in the regulation of hepcidin expression and iron metabolism; 3) Study of TGF-β/BMP
ligands interaction with receptors using biochemical and cell biology techniques. Ultimately,
by studying this complex but important signaling system, we aim to generate new knowledge
that will lead to novel therapeutic options for chronic diseases such as chronic kidney
disease, hemochromatosis and anemia of chronic disease.
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver
Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice.
Repulsive guidance molecule b inhibits renal cyst development through the bone morphogenetic protein signaling pathway.
Cell Signal. 2016;28(12):1842-1851 - PMID: 27575743
A multidisciplinary team lead by Dr. Herbert Y. Lin
and including CSB members Dr. Dennis Ausiello, Dr. Stanley Shaw, and Dr. Ravi Thadhani, Chief of Nephrology, working with Professor Michael Cima of the MIT Dept. of Materials Science and Engineering, have won a MGH-MIT Strategic Partnership Grand Challenge
in Diagnostics larger grant. The award will support the development of a portable, noninvasive device capable of accurately measuring blood volume using nuclear magnetic resonance (NMR). In addition, Dr. Lin is a Co-Investigator on a winning smaller grant lead by Dr. Anthony Samir of the Department of Radiology for the adaptation of an optical system for localizing the position of ultrasound transducers, which compensates for individual operator differences, to the noninvasive monitoring of tissue loss in chronic kidney disease. (pdf
A National Public Radio interview and article
related to the MGH-MIT Grand Challenge grants featuring Drs. Lin, Ausiello and Cima appeared recently.
On October 1st, 2013 the Division of Nephrology announced that Dr. Herbert Y. Lin
will assume the position of Director of Translational Research. Dr. Lin leads a highly productive laboratory within the Division of Nephrology and Center for Systems Biology focusing on TGF-β/BMP signaling pathways and is widely recognized for his mentorship of junior investigators.
2012-03-09: Jodie Babitt, MD
, is the recipient of the 2012 MGH Howard Goodman Fellowship. This highly competitive $300,000 award is "intended to further the career of outstanding young scientists who have demonstrated the potential to rise to a leadership position in their chosen field"
. Jodie won this award for her pioneering bench-to-bedside work on the identification and development of novel regulators of body iron homeostasis. Congratulations Jodie.