Pai, Sara, MD, PhD

Associate Professor

Director, Translational Research in Head and Neck Cancer

Phone: 617-726-5251
Email: sara.pai@mgh.harvard.edu
Lab: Pai, Sara

Selected Publications (from total 89)

  • Mattox AK, Roelands J, Saal TM, Cheng Y, Rinchai D, Hendrickx W, Young GD, Diefenbach TJ, Berger AE, Westra WH, Bishop JA, Faquin WC, Marincola FM, Pittet MJ, Bedognetti D, Pai SI Myeloid cells are enriched in tonsillar crypts providing insight into the host tropism of HPV. Am J Pathol. 2021;191(10):1774-1786 - PMID: 34303699 - PMCID: PMC8491092

  • Oh J, Carlson JCT, Landeros C, Lee H, Ferguson S, Faquin WC, Clark JR, Pittet MJ, Pai SI, Weissleder R Rapid serial immunoprofiling of the tumor immune microenvironment by fine needle sampling. Clin Cancer Res. 2021;27(17):4781-4793 - PMID: 34233961 - PMCID: PMC8416923 - DOI: 10.1158/1078-0432.CCR-21-1252

  • Bill R, Deschler DG, Pittet MJ, Pai SI, Sadow PM, Park JC Diagnostic challenges and successful organ-preserving therapy in a case of secretory carcinoma of minor salivary glands. Cancer Rep (Hoboken). 2021;:e1491 - PMID: 34231337 - DOI: 10.1002/cnr2.1491

  • Siwicki M, Gort-Freitas NA, Messemaker M, Bill R, Gungabeesoon J, Engblom C, Zilionis R, Garris C, Gerhard GM, Kohl A, Lin Y, Zou AE, Cianciaruso C, Bolli E, Pfirschke C, Lin YJ, Piot C, Mindur JE, Talele N, Kohler RH, Iwamoto Y, Mino-Kenudson M, Pai SI, deVito C, Koessler T, Merkler D, Coukos A, Wicky A, Fraga M, Sempoux C, Jain RK, Dietrich PY, Michielin O, Weissleder R, Klein AM, Pittet MJ Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy. Sci Immunol. 2021;6(61):ePub - PMID: 34215680 - DOI: 10.1126/sciimmunol.abi7083

  • Wolkow N, Jakobiec FA, Afrogheh AH, Pai SI, Faquin WC High Expression of Programmed Death Ligand 1 and Programmed Death Ligand 2 in Ophthalmic Sebaceous Carcinoma: The Case for a Clinical Trial of Checkpoint Inhibitors. Am J Ophthalmol. 2020;220:128-139 - PMID: 32730911 - DOI: 10.1016/j.ajo.2020.07.031

  • Wolkow N, Jakobiec FA, Afrogheh AH, Kidd M, Eagle RC, Pai SI, Faquin WC PD-L1 and PD-L2 Expression Levels Are Low in Primary and Secondary Adenoid Cystic Carcinomas of the Orbit: Therapeutic Implications. Ophthalmic Plast Reconstr Surg. 2020;36(5):444-450 - PMID: 31990894 - PMCID: PMC7423458 - DOI: 10.1097/IOP.0000000000001585

  • Mahmood U, Bang A, Chen YH, Mak RH, Lorch JH, Hanna GJ, Nishino M, Manuszak C, Thrash EM, Severgnini M, Sanborn M, Sridharan V, Margalit DN, Tishler RB, Busse PM, Willers H, Mamon HJ, Yoo HJ, Pai SI, Wirth LJ, Haddad RI, Chau NG, Schoenfeld JD A Randomized Phase 2 Study of Pembrolizumab With or Without Radiation in Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma. Int J Radiat Oncol Biol Phys. 2020;109(1):134-144 - PMID: 32781104 - DOI: 10.1016/j.ijrobp.2020.08.018

  • Gastman B, Agarwal PK, Berger A, Boland G, Broderick S, Butterfield LH, Byrd D, Fecci PE, Ferris RL, Fong Y, Goff SL, Grabowski MM, Ito F, Lim M, Lotze MT, Mahdi H, Malafa M, Morris CD, Murthy P, Neves RI, Odunsi A, Pai SI, Prabhakaran S, Rosenberg SA, Saoud R, Sethuraman J, Skitzki J, Slingluff CL, Sondak VK, Sunwoo JB, Turcotte S, Yeung CC, Kaufman HL Defining best practices for tissue procurement in immuno-oncology clinical trials: consensus statement from the Society for Immunotherapy of Cancer Surgery Committee. J Immunother Cancer. 2020;8(2):ePub - PMID: 33199512 - PMCID: PMC7670953 - DOI: 10.1136/jitc-2020-001583

  • Pai SI, Cesano A, Marincola FM The Paradox of Cancer Immune Exclusion: Immune Oncology Next Frontier. Cancer Treat Res. 2020;180:173-195 - PMID: 32215870 - PMCID: PMC7423459 - DOI: 10.1007/978-3-030-38862-1_6

  • Millar DG, Ramjiawan RR, Kawaguchi K, Gupta N, Chen J, Zhang S, Nojiri T, Ho WW, Aoki S, Jung K, Chen I, Shi F, Heather JM, Shigeta K, Morton LT, Sepulveda S, Wan L, Joseph R, Minogue E, Khatri A, Bardia A, Ellisen LW, Corcoran RB, Hata AN, Pai SI, Jain RK, Fukumura D, Duda DG, Cobbold M Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy. Nat Biotechnol. 2020;38(4):420-425 - PMID: 32042168 - PMCID: PMC7456461 - DOI: 10.1038/s41587-019-0404-8

  • Pai SI, Faquin WC, Sadow PM, Pittet MJ, Weissleder R New Technology on the Horizon: Fast Analytical Screening Technique FNA (FAST-FNA) Enables Rapid, Multiplex Biomarker Analysis in Head and Neck Cancers. Cancer Cytopathol. 2020;128(11):782-791 - PMID: 32841527 - PMCID: PMC8276888 - DOI: 10.1002/cncy.22305

  • Wolkow N, Jakobiec FA, Afrogheh AH, Eagle RC, Pai SI, Faquin WC Programmed Cell Death 1 Ligand 1 and Programmed Cell Death 1 Ligand 2 Are Expressed in Conjunctival Invasive Squamous Cell Carcinoma: Therapeutic Implications. Am J Ophthalmol. 2019;200:226-241 - PMID: 30633894 - PMCID: PMC7456462 - DOI: 10.1016/j.ajo.2018.12.020

  • Ishida E, Lee J, Campbell JS, Chakravarty PD, Katori Y, Ogawa T, Johnson L, Mukhopadhyay A, Faquin WC, Lin DT, Wirth LJ, Pierce RH, Pai SI Intratumoral delivery of an HPV vaccine elicits a broad anti-tumor immune response that translates into a potent anti-tumor effect in a preclinical murine HPV model. Cancer Immunol Immunother. 2019;68(8):1273-1286 - PMID: 31243491 - PMCID: PMC6684362 - DOI: 10.1007/s00262-019-02357-1

  • Pai SI, Cohen EEW, Lin D, Fountzilas G, Kim ES, Mehlhorn H, Baste N, Clayburgh D, Lipworth L, Resteghini C, Shara N, Fujii T, Zhang J, Stokes M, Wang H, Twumasi-Ankrah P, Wildsmith S, Khaliq A, Melillo G, Shire N SUPREME-HN: a retrospective biomarker study assessing the prognostic value of PD-L1 expression in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck. J Transl Med. 2019;17(1):429 - PMID: 31878938 - PMCID: PMC6933901 - DOI: 10.1186/s12967-019-02182-1

  • Pai SI, Marincola FM Peripheral Circulating CD45RA-FOXP3hi T Regulatory (TReg) II Cells Provide a Window into the Activity of Intratumoral TReg Cells. Trends Cancer. 2019;6(1):3-6 - PMID: 31952778 - PMCID: PMC7390988 - DOI: 10.1016/j.trecan.2019.11.003

  • Pai SI, Faivre S, Licitra L, Machiels JP, Vermorken JB, Bruzzi P, Gruenwald V, Giglio RE, Leemans CR, Seiwert TY, Soulieres D Comparative analysis of the phase III clinical trials of anti-PD1 monotherapy in head and neck squamous cell carcinoma patients (CheckMate 141 and KEYNOTE 040). J Immunother Cancer. 2019;7(1):96 - PMID: 30944020 - PMCID: PMC6446400 - DOI: 10.1186/s40425-019-0578-0

  • Banik G, Betts CB, Liudahl SM, Sivagnanam S, Kawashima R, Cotechini T, Larson W, Goecks J, Pai SI, Clayburgh DR, Tsujikawa T, Coussens LM High-dimensional multiplexed immunohistochemical characterization of immune contexture in human cancers. Methods Enzymol. 2019;635:1-20 - PMID: 32122539 - PMCID: PMC7390987 - DOI: 10.1016/bs.mie.2019.05.039

  • Kartha VK, Alamoud KA, Sadykov K, Nguyen BC, Laroche F, Feng H, Lee J, Pai SI, Varelas X, Egloff AM, Snyder-Cappione JE, Belkina AC, Bais MV, Monti S, Kukuruzinska MA Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer. Genome Med. 2018;10(1):54 - PMID: 30029671 - PMCID: PMC6053793 - DOI: 10.1186/s13073-018-0569-7

  • Rosenbaum MW, Gigliotti BJ, Pai SI, Parangi S, Wachtel H, Mino-Kenudson M, Gunda V, Faquin WC PD-L1 and IDO1 Are Expressed in Poorly Differentiated Thyroid Carcinoma. Endocr Pathol. 2018;29(1):59-67 - PMID: 29372535 - PMCID: PMC6500591 - DOI: 10.1007/s12022-018-9514-y

  • Garris CS*, Arlauckas SP*, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12. Immunity. 2018;49:1-14 - PMID: 30552023 - PMCID: PMC6301092 - DOI: 10.1016/j.immuni.2018.09.024

  • Mattox AK, Lee J, Westra WH, Pierce RH, Ghossein R, Faquin WC, Diefenbach TJ, Morris LG, Lin DT, Wirth LJ, Lefranc-Torres A, Ishida E, Chakravarty PD, Johnson L, Zeng YC, Chen H, Poznansky MC, Iyengar NM, Pai SI PD-1 Expression in Head and Neck Squamous Cell Carcinomas Derives Primarily from Functionally Anergic CD4+ TILs in the Presence of PD-L1+ TAMs. Cancer Res. 2017;77(22):6365-6374 - PMID: 28947422 - PMCID: PMC5690870 - DOI: 10.1158/0008-5472.CAN-16-3453

  • Pai SI, Wirth LJ Checkpoint cluster: biomarkers of response. Emerg Top Life Sci. 2017;1(5):501-508 - PMID: 33525795 - DOI: 10.1042/ETLS20170077

  • Pai SI, Jack Lee J, Carey TE, Westra WH, Ferrone S, Moore C, Mosunjac MB, Shin DM, Ferris RL, HNC SPORE HIV supplement consortium HLA class I antigen processing machinery (APM) component expression and PD-1:PD-L1 pathway activation in HIV-infected head and neck cancers. Oral Oncol. 2017;77:92-97 - PMID: 29362132 - PMCID: PMC5786382 - DOI: 10.1016/j.oraloncology.2017.12.014

  • Zhang H, Kim S, Chen Z, Nannapaneni S, Chen AY, Moore CE, Sica G, Mosunjac M, Nguyen MLT, D'Souza G, Carey TE, Peterson LA, McHugh JB, Graham M, Komarck CM, Wolf GT, Walline HM, Bellile E, Riddell J, Pai SI, Sidransky D, Westra WH, William WN, Lee JJ, El-Naggar AK, Ferris RL, Seethala R, Grandis JR, Chen ZG, Saba NF, Shin DM, Head and Neck Cancer SPORE HIV supplement consortium Prognostic biomarkers in patients with human immunodeficiency virus-positive disease with head and neck squamous cell carcinoma. Head Neck. 2017;39(12):2433-2443 - PMID: 28945296 - PMCID: PMC5808949 - DOI: 10.1002/hed.24911

  • Gleber-Netto FO, Zhao M, Trivedi S, Wang J, Jasser S, McDowell C, Kadara H, Zhang J, Wang J, William WN, Lee JJ, Nguyen ML, Pai SI, Walline HM, Shin DM, Ferris RL, Carey TE, Myers JN, Pickering CR, Head and Neck Cancer Specialized Program of Research Excellence (SPORE) Human Immunodeficiency Virus (HIV) Supplement Consortium Distinct pattern of TP53 mutations in human immunodeficiency virus-related head and neck squamous cell carcinoma. Cancer. 2017;124(1):84-94 - PMID: 29053175 - PMCID: PMC5785080 - DOI: 10.1002/cncr.31063

  • Mohan S, Pai SI, Bhattacharyya N Adjuvant radiotherapy is not supported in patients with verrucous carcinoma of the oral cavity. Laryngoscope. 2017;127(6):1334-1338 - PMID: 28150306 - PMCID: PMC7388729 - DOI: 10.1002/lary.26443

  • Pai SI, Faquin WC Programmed cell death ligand 1 as a biomarker in head and neck cancer. Cancer Cytopathol. 2017;125(7):529-533 - PMID: 28472542 - PMCID: PMC5690557 - DOI: 10.1002/cncy.21872

  • Walline HM, Carey TE, Goudsmit CM, Bellile EL, D'Souza G, Peterson LA, McHugh JB, Pai SI, Lee JJ, Shin DM, Ferris RL, HNC SPORE HIV supplement consortium High-Risk HPV, Biomarkers, and Outcome in Matched Cohorts of Head and Neck Cancer Patients Positive and Negative for HIV. Mol Cancer Res. 2016;15(2):179-188 - PMID: 27899422 - PMCID: PMC5290187 - DOI: 10.1158/1541-7786.MCR-16-0255

  • Peng S, Mattox A, Best SR, Barbu AM, Burns JA, Akpeng B, Jeang J, Yang B, Ishida E, Hung CF, Wu TC, Pai SI Identification of the murine H-2D(b) and human HLA-A*0201 MHC class I-restricted HPV6 E7-specific cytotoxic T lymphocyte epitopes. Cancer Immunol Immunother. 2016;65(3):261-71 - PMID: 26759151 - PMCID: PMC5690558 - DOI: 10.1007/s00262-016-1793-x

  • Pai SI, Zandberg DP, Strome SE The role of antagonists of the PD-1:PD-L1/PD-L2 axis in head and neck cancer treatment. Oral Oncol. 2016;61:152-8 - PMID: 27503244 - PMCID: PMC5690560 - DOI: 10.1016/j.oraloncology.2016.08.001

  • Brotherton JM, Jit M, Gravitt PE, Brisson M, Kreimer AR, Pai SI, Fakhry C, Monsonego J, Franceschi S Eurogin Roadmap 2015: How has HPV knowledge changed our practice: Vaccines. Int J Cancer. 2016;139(3):510-7 - PMID: 26916230 - PMCID: PMC7388730 - DOI: 10.1002/ijc.30063

  • Peng S, Wang JW, Karanam B, Wang C, Huh WK, Alvarez RD, Pai SI, Hung CF, Wu TC, Roden RB Sequential cisplatin therapy and vaccination with HPV16 E6E7L2 fusion protein in saponin adjuvant GPI-0100 for the treatment of a model HPV16+ cancer. PLoS ONE. 2015;10(1):e116389 - PMID: 25560237 - PMCID: PMC4283968 - DOI: 10.1371/journal.pone.0116389

  • Anderson KS, Gerber JE, D'Souza G, Pai SI, Cheng JN, Alam R, Kesiraju S, Chowell D, Gross ND, Haddad R, Gillison ML, Posner M Biologic predictors of serologic responses to HPV in oropharyngeal cancer: The HOTSPOT study. Oral Oncol. 2015;51(8):751-8 - PMID: 26094591 - PMCID: PMC4982366 - DOI: 10.1016/j.oraloncology.2015.05.007

  • Pierce RH, Campbell JS, Pai SI, Brody JD, Kohrt HE In-situ tumor vaccination: Bringing the fight to the tumor. Hum Vaccin Immunother. 2015;11(8):1901-9 - PMID: 26055074 - PMCID: PMC4635874 - DOI: 10.1080/21645515.2015.1049779

  • Smith DF, Maleki Z, Coughlan D, Gooi Z, Akpeng B, Ogawa T, Bishop JA, Frick KD, Agrawal N, Gourin CG, Ha PK, Koch WM, Richmon JD, Westra WH, Pai SI Human papillomavirus status of head and neck cancer as determined in cytologic specimens using the hybrid-capture 2 assay. Oral Oncol. 2014;50(6):600-4 - PMID: 24630260 - PMCID: PMC4318229 - DOI: 10.1016/j.oraloncology.2014.02.011

  • D'Souza G, Gross ND, Pai SI, Haddad R, Anderson KS, Rajan S, Gerber J, Gillison ML, Posner MR Oral human papillomavirus (HPV) infection in HPV-positive patients with oropharyngeal cancer and their partners. J Clin Oncol. 2014;32(23):2408-15 - PMID: 24778397 - PMCID: PMC4263818 - DOI: 10.1200/JCO.2014.55.1341

  • Aragon Han P, Olson MT, Fazeli R, Prescott JD, Pai SI, Schneider EB, Tufano RP, Zeiger MA The impact of molecular testing on the surgical management of patients with thyroid nodules. Ann Surg Oncol. 2014;21(6):1862-9 - PMID: 24522987 - DOI: 10.1245/s10434-014-3508-x

  • Dʼsouza G, Carey TE, William WN, Nguyen ML, Ko EC, Riddell J, Pai SI, Gupta V, Walline HM, Lee JJ, Wolf GT, Shin DM, Grandis JR, Ferris RL Epidemiology of head and neck squamous cell cancer among HIV-infected patients. J Acquir Immune Defic Syndr. 2014;65(5):603-10 - PMID: 24326607 - PMCID: PMC3999230 - DOI: 10.1097/QAI.0000000000000083

  • Ahn J, Bishop JA, Akpeng B, Pai SI, Best SR Xenograft model for therapeutic drug testing in recurrent respiratory papillomatosis. Ann Otol Rhinol Laryngol. 2014;124(2):110-5 - PMID: 25124839 - PMCID: PMC7423457 - DOI: 10.1177/0003489414546400

  • Gooi Z, Ward BK, Mener DJ, Ozgursoy OB, Pai SI A staged thyroidectomy approach for gastric bypass patients. Laryngoscope. 2014;125(4):1028-30 - PMID: 25043176 - DOI: 10.1002/lary.24835

  • Marcus C, Whitworth PW, Surasi DS, Pai SI, Subramaniam RM PET/CT in the management of thyroid cancers. AJR Am J Roentgenol. 2014;202(6):1316-29 - PMID: 24848831 - DOI: 10.2214/AJR.13.11673

  • Bishop JA, Ogawa T, Stelow EB, Moskaluk CA, Koch WM, Pai SI, Westra WH Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract. Am J Surg Pathol. 2013;37(6):836-44 - PMID: 23598962 - PMCID: PMC3653997 - DOI: 10.1097/PAS.0b013e31827b1cd6

  • Jara SM, Carson KA, Pai SI, Agrawal N, Richmon JD, Prescott JD, Dackiw A, Zeiger MA, Bishop JA, Tufano RP The relationship between chronic lymphocytic thyroiditis and central neck lymph node metastasis in North American patients with papillary thyroid carcinoma. Surgery. 2013;154(6):1272-80; discussion 1280-2 - PMID: 24238047 - DOI: 10.1016/j.surg.2013.07.021

  • Lin BM, Wang H, D'Souza G, Zhang Z, Fakhry C, Joseph AW, Drake VE, Sanguineti G, Westra WH, Pai SI Long-term prognosis and risk factors among patients with HPV-associated oropharyngeal squamous cell carcinoma. Cancer. 2013;119(19):3462-71 - PMID: 23861037 - PMCID: PMC3788050 - DOI: 10.1002/cncr.28250

  • Wu CY, Yang LH, Yang HY, Knoff J, Peng S, Lin YH, Wang C, Alvarez RD, Pai SI, Roden RB, Hung CF, Wu TC Enhanced cancer radiotherapy through immunosuppressive stromal cell destruction in tumors. Clin Cancer Res. 2013;20(3):644-57 - PMID: 24300786 - PMCID: PMC3946442 - DOI: 10.1158/1078-0432.CCR-13-1334

  • Pai SI Adaptive immune resistance in HPV-associated head and neck squamous cell carcinoma. OncoImmunology. 2013;2(5):e24065 - PMID: 23762795 - PMCID: PMC3667901 - DOI: 10.4161/onci.24065

  • Bishop JA, Guo TW, Smith DF, Wang H, Ogawa T, Pai SI, Westra WH Human papillomavirus-related carcinomas of the sinonasal tract. Am J Surg Pathol. 2013;37(2):185-92 - PMID: 23095507 - PMCID: PMC3545097 - DOI: 10.1097/PAS.0b013e3182698673

  • Pai SI Mission impossible: how HPV-associated head and neck cancers escape a primed immune response. Oral Oncol. 2013;49(8):723-5 - PMID: 23643070 - DOI: 10.1016/j.oraloncology.2013.03.453

  • Lyford-Pike S, Peng S, Young GD, Taube JM, Westra WH, Akpeng B, Bruno TC, Richmon JD, Wang H, Bishop JA, Chen L, Drake CG, Topalian SL, Pardoll DM, Pai SI Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma. Cancer Res. 2013;73(6):1733-41 - PMID: 23288508 - PMCID: PMC3602406 - DOI: 10.1158/0008-5472.CAN-12-2384

  • Xing M, Alzahrani AS, Carson KA, Viola D, Elisei R, Bendlova B, Yip L, Mian C, Vianello F, Tuttle RM, Robenshtok E, Fagin JA, Puxeddu E, Fugazzola L, Czarniecka A, Jarzab B, O'Neill CJ, Sywak MS, Lam AK, Riesco-Eizaguirre G, Santisteban P, Nakayama H, Tufano RP, Pai SI, Zeiger MA, Westra WH, Clark DP, Clifton-Bligh R, Sidransky D, Ladenson PW, Sykorova V Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer. JAMA. 2013;309(14):1493-501 - PMID: 23571588 - PMCID: PMC3791140 - DOI: 10.1001/jama.2013.3190

  • Fan KY, Gogineni H, Zaboli D, Lake S, Zahurak ML, Best SR, Levine MA, Tang M, Zinreich ES, Saunders JR, Califano JA, Blanco RG, Pai SI, Messing B, Ha PK Comparison of acute toxicities in two primary chemoradiation regimens in the treatment of advanced head and neck squamous cell carcinoma. Ann Surg Oncol. 2012;19(6):1980-7 - PMID: 22290566 - PMCID: PMC3715048 - DOI: 10.1245/s10434-012-2219-4

  • Bishop JA, Ogawa T, Chang X, Illei PB, Gabrielson E, Pai SI, Westra WH HPV analysis in distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma. Am J Surg Pathol. 2012;36(1):142-8 - PMID: 22173119 - PMCID: PMC3273906 - DOI: 10.1097/PAS.0b013e3182395c7b

  • Teixeira GV, Chikota H, Teixeira T, Manfro G, Pai SI, Tufano RP Incidence of malignancy in thyroid nodules determined to be follicular lesions of undetermined significance on fine-needle aspiration. World J Surg. 2012;36(1):69-74 - PMID: 22057754 - DOI: 10.1007/s00268-011-1336-8

  • Peng S, Lyford-Pike S, Akpeng B, Wu A, Hung CF, Hannaman D, Saunders JR, Wu TC, Pai SI Low-dose cyclophosphamide administered as daily or single dose enhances the antitumor effects of a therapeutic HPV vaccine. Cancer Immunol Immunother. 2012;62(1):171-82 - PMID: 23011589 - PMCID: PMC3543472 - DOI: 10.1007/s00262-012-1322-5

  • Joseph AW, Ogawa T, Bishop JA, Lyford-Pike S, Chang X, Phelps TH, Westra WH, Pai SI Molecular etiology of second primary tumors in contralateral tonsils of human papillomavirus-associated index tonsillar carcinomas. Oral Oncol. 2012;49(3):244-8 - PMID: 23062994 - PMCID: PMC3548989 - DOI: 10.1016/j.oraloncology.2012.09.009

  • Best SR, Niparko KJ, Pai SI Biology of human papillomavirus infection and immune therapy for HPV-related head and neck cancers. Otolaryngol Clin North Am. 2012;45(4):807-22 - PMID: 22793854 - PMCID: PMC3398423 - DOI: 10.1016/j.otc.2012.04.005

  • Pai SI HPV-associated head and neck cancers. Otolaryngol Clin North Am. 2012;45(4):xi-xii - PMID: 22793861 - DOI: 10.1016/j.otc.2012.05.003

  • Gomez NR, Kouniavsky G, Tsai HL, Somervell H, Pai SI, Tufano RP, Umbricht C, Kowalski J, Dackiw AP, Zeiger MA Tumor size and presence of calcifications on ultrasonography are pre-operative predictors of lymph node metastases in patients with papillary thyroid cancer. J Surg Oncol. 2011;104(6):613-6 - PMID: 21744345 - DOI: 10.1002/jso.21891

  • Bishop JA, Maleki Z, Valsamakis A, Ogawa T, Chang X, Pai SI, Westra WH Application of the hybrid capture 2 assay to squamous cell carcinomas of the head and neck: a convenient liquid-phase approach for the reliable determination of human papillomavirus status. Cancer Cytopathol. 2011;120(1):18-25 - PMID: 21751428 - PMCID: PMC3197962 - DOI: 10.1002/cncy.20175

  • Wu G, Fraser S, Pai SI, Farrag TY, Ladenson PW, Tufano RP Determining the extent of lateral neck dissection necessary to establish regional disease control and avoid reoperation after previous total thyroidectomy and radioactive iodine for papillary thyroid cancer. Head Neck. 2011;34(10):1418-21 - PMID: 22052539 - DOI: 10.1002/hed.21937

  • Best SR, Ha PK, Blanco RG, Saunders JR, Zinreich ES, Levine MA, Pai SI, Walker M, Trachta J, Ulmer K, Murakami P, Thompson R, Califano JA, Messing BP Factors associated with pharyngoesophageal stricture in patients treated with concurrent chemotherapy and radiation therapy for oropharyngeal squamous cell carcinoma. Head Neck. 2011;33(12):1727-34 - PMID: 21246640 - PMCID: PMC4695991 - DOI: 10.1002/hed.21657

  • Park IS, Chang X, Loyo M, Wu G, Chuang A, Kim MS, Chae YK, Lyford-Pike S, Westra WH, Saunders JR, Sidransky D, Pai SI Characterization of the methylation patterns in human papillomavirus type 16 viral DNA in head and neck cancers. Cancer Prev Res (Phila). 2011;4(2):207-17 - PMID: 21292634 - PMCID: PMC3079312 - DOI: 10.1158/1940-6207.CAPR-10-0147

  • Anderson KS, Wong J, D'Souza G, Riemer AB, Lorch J, Haddad R, Pai SI, Longtine J, McClean M, LaBaer J, Kelsey KT, Posner M Serum antibodies to the HPV16 proteome as biomarkers for head and neck cancer. Br J Cancer. 2011;104(12):1896-905 - PMID: 21654689 - PMCID: PMC3111202 - DOI: 10.1038/bjc.2011.171

  • Cho YG, Chang X, Park IS, Yamashita K, Shao C, Ha PK, Pai SI, Sidransky D, Kim MS Promoter methylation of leukemia inhibitory factor receptor gene in colorectal carcinoma. Int J Oncol. 2011;39(2):337-44 - PMID: 21617854 - PMCID: PMC3601031 - DOI: 10.3892/ijo.2011.1050

  • Wu G, Pai SI, Agrawal N, Richmon J, Dackiw A, Tufano RP Profile of patients with completion thyroidectomy and assessment of their suitability for outpatient surgery. Otolaryngol Head Neck Surg. 2011;145(5):727-31 - PMID: 21860058 - DOI: 10.1177/0194599811416749

  • Kang TH, Noh KH, Kim JH, Bae HC, Lin KY, Monie A, Pai SI, Hung CF, Wu TC, Kim TW Ectopic expression of X-linked lymphocyte-regulated protein pM1 renders tumor cells resistant to antitumor immunity. Cancer Res. 2010;70(8):3062-70 - PMID: 20395201 - PMCID: PMC2861497 - DOI: 10.1158/0008-5472.CAN-09-3856

  • Kim D, Hoory T, Monie A, Wu A, Hsueh WT, Pai SI, Hung CF Delivery of chemotherapeutic agents using drug-loaded irradiated tumor cells to treat murine ovarian tumors. J Biomed Sci. 2010;17:61 - PMID: 20659328 - PMCID: PMC2918546 - DOI: 10.1186/1423-0127-17-61

  • Peng S, Best SR, Hung CF, Loyo M, Lyford-Pike S, Flint PW, Tunkel DE, Saunders JR, Wu TC, Pai SI Characterization of human papillomavirus type 11-specific immune responses in a preclinical model. Laryngoscope. 2010;120(3):504-10 - PMID: 20025042 - PMCID: PMC2908018 - DOI: 10.1002/lary.20745

  • Wu A, Zeng Q, Kang TH, Peng S, Roosinovich E, Pai SI, Hung CF Innovative DNA vaccine for human papillomavirus (HPV)-associated head and neck cancer. Gene Ther. 2010;18(3):304-12 - PMID: 20981112 - PMCID: PMC3032008 - DOI: 10.1038/gt.2010.151

  • Lyford-Pike S, Westra WH, Loyo M, Peng S, Hung CF, Wu AA, Flint PW, Tunkel DE, Saunders JR, Pai SI Differential expression of epidermal growth factor receptor in juvenile and adult-onset recurrent respiratory papillomatosis. Histopathology. 2010;57(5):768-70 - PMID: 21083608 - DOI: 10.1111/j.1365-2559.2010.03691.x

  • Tufano RP, Pai SI Thyroid and parathyroid surgery. Preface. Otolaryngol Clin North Am. 2010;43(2):xiii-xiv - PMID: 20510709 - DOI: 10.1016/j.otc.2010.04.001

  • Pai SI, Tufano RP Reoperation for recurrent/persistent well-differentiated thyroid cancer. Otolaryngol Clin North Am. 2010;43(2):353-63, ix - PMID: 20510718 - DOI: 10.1016/j.otc.2010.02.004

  • Best SR, Peng S, Juang CM, Hung CF, Hannaman D, Saunders JR, Wu TC, Pai SI Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery. Vaccine. 2009;27(40):5450-9 - PMID: 19622402 - PMCID: PMC2745985 - DOI: 10.1016/j.vaccine.2009.07.005

  • Hillel AT, Fakhry C, Pai SI, Williams MF, Blanco RG, Zinreich ES, Levine MA, Westra WH, Saunders JR, Ha PK Selective versus comprehensive neck dissection after chemoradiation for advanced oropharyngeal squamous cell carcinoma. Otolaryngol Head Neck Surg. 2009;141(6):737-42 - PMID: 19932847 - DOI: 10.1016/j.otohns.2009.09.010

  • Chuang CM, Monie A, Wu A, Pai SI, Hung CF Combination of viral oncolysis and tumor-specific immunity to control established tumors. Clin Cancer Res. 2009;15(14):4581-8 - PMID: 19584165 - PMCID: PMC3076709 - DOI: 10.1158/1078-0432.CCR-08-2685

  • Kang TH, Chung JY, Monie A, Pai SI, Hung CF, Wu TC Enhancing DNA vaccine potency by co-administration of xenogenic MHC class-I DNA. Gene Ther. 2009;17(4):531-40 - PMID: 19940864 - PMCID: PMC2851845 - DOI: 10.1038/gt.2009.152

  • Sedaghat AR, Zhang Z, Begum S, Palermo R, Best S, Ulmer KM, Levine M, Zinreich E, Messing BP, Gold D, Wu AA, Niparko KJ, Kowalski J, Hirata RM, Saunders JR, Westra WH, Pai SI Prognostic significance of human papillomavirus in oropharyngeal squamous cell carcinomas. Laryngoscope. 2009;119(8):1542-9 - PMID: 19522004 - DOI: 10.1002/lary.20533

  • Tsen SW, Wu CY, Meneshian A, Pai SI, Hung CF, Wu TC Femtosecond laser treatment enhances DNA transfection efficiency in vivo. J Biomed Sci. 2009;16:36 - PMID: 19338665 - PMCID: PMC2669473 - DOI: 10.1186/1423-0127-16-36

  • Pai SI, Westra WH Molecular pathology of head and neck cancer: implications for diagnosis, prognosis, and treatment. Annu Rev Pathol. 2009;4:49-70 - PMID: 18729723 - PMCID: PMC3703474 - DOI: 10.1146/annurev.pathol.4.110807.092158

  • Goldenberg D, Begum S, Westra WH, Khan Z, Sciubba J, Pai SI, Califano JA, Tufano RP, Koch WM Cystic lymph node metastasis in patients with head and neck cancer: An HPV-associated phenomenon. Head Neck. 2008;30(7):898-903 - PMID: 18383529 - DOI: 10.1002/hed.20796

  • Noh KH, Kang TH, Kim JH, Pai SI, Lin KY, Hung CF, Wu TC, Kim TW Activation of Akt as a mechanism for tumor immune evasion. Mol Ther. 2008;17(3):439-47 - PMID: 19107122 - PMCID: PMC2835083 - DOI: 10.1038/mt.2008.255

  • Loyo M, Pai SI, Netto GJ, Tunkel DE Aggressive recurrent respiratory papillomatosis in a neonate. Int J Pediatr Otorhinolaryngol. 2008;72(6):917-20 - PMID: 18423627 - DOI: 10.1016/j.ijporl.2008.02.022

  • Pai SI, Tufano RP Central compartment neck dissection for thyroid cancer. Technical considerations. ORL J Otorhinolaryngol Relat Spec. 2008;70(5):292-7 - PMID: 18971593 - DOI: 10.1159/000149831

  • Wu AA, Niparko KJ, Pai SI Immunotherapy for head and neck cancer. J Biomed Sci. 2008;15(3):275-89 - PMID: 18392689 - DOI: 10.1007/s11373-008-9247-x

  • Loyo M, Pai SI The molecular genetics of laryngeal cancer. Otolaryngol Clin North Am. 2008;41(4):657-72, v - PMID: 18570952 - DOI: 10.1016/j.otc.2008.01.019

  • Lin LM, Pai SI, Flint PW A retropharyngeal pseudoabscess in a patient with paroxysmal nocturnal hemoglobinuria. Otolaryngol Head Neck Surg. 2007;137(4):684-6 - PMID: 17903595 - DOI: 10.1016/j.otohns.2007.01.032

  • Kang TH, Lee JH, Song CK, Han HD, Shin BC, Pai SI, Hung CF, Trimble C, Lim JS, Kim TW, Wu TC Epigallocatechin-3-gallate enhances CD8+ T cell-mediated antitumor immunity induced by DNA vaccination. Cancer Res. 2007;67(2):802-11 - PMID: 17234792 - PMCID: PMC3181129 - DOI: 10.1158/0008-5472.CAN-06-2638

  • Pai SI, Goldstein BJ, Studeman KD, Westra WH, Tufano RP Concurrent sporadic parathyroid adenoma and carcinoma. Am J Otolaryngol. 2006;27(5):346-8 - PMID: 16935182 - DOI: 10.1016/j.amjoto.2005.11.017

  • Pai SI, Lin YY, Macaes B, Meneshian A, Hung CF, Wu TC Prospects of RNA interference therapy for cancer. Gene Ther. 2006;13(6):464-77 - PMID: 16341059 - DOI: 10.1038/sj.gt.3302694

  • Flint PW, Li ZB, Lehar M, Saito K, Pai SI Laryngeal muscle surface receptors identified using random phage library. Laryngoscope. 2005;115(11):1930-7 - PMID: 16319601 - DOI: 10.1097/01.mlg.0000172273.98418.8d

  • Kim TW, Hung CF, Zheng M, Boyd DA, He L, Pai SI, Wu TC A DNA vaccine co-expressing antigen and an anti-apoptotic molecule further enhances the antigen-specific CD8+ T-cell immune response. J Biomed Sci. 2004;11(4):493-9 - PMID: 15153784 - DOI: 10.1007/BF02256098

  • Kim JW, Hung CF, Juang J, He L, Kim TW, Armstrong DK, Pai SI, Chen PJ, Lin CT, Boyd DA, Wu TC Comparison of HPV DNA vaccines employing intracellular targeting strategies. Gene Ther. 2004;11(12):1011-8 - PMID: 14985791 - DOI: 10.1038/sj.gt.3302252

  • Pai SI, Limb CJ, Nicol T, Williams MF Leiomyosarcoma of the auricle. Otolaryngol Head Neck Surg. 2003;128(3):442-4 - PMID: 12646855 - DOI: 10.1067/mhn.2003.16

  • Ha PK, Pai SI, Westra WH, Gillison ML, Tong BC, Sidransky D, Califano JA Real-time quantitative PCR demonstrates low prevalence of human papillomavirus type 16 in premalignant and malignant lesions of the oral cavity. Clin Cancer Res. 2002;8(5):1203-9 - PMID: 12006539

  • Cheng WF, Hung CF, Pai SI, Hsu KF, He L, Ling M, Wu TC Repeated DNA vaccinations elicited qualitatively different cytotoxic T lymphocytes and improved protective antitumor effects. J Biomed Sci. 2002;9(6 Pt 2):675-87 - PMID: 12432234 - DOI: 10.1159/000067285

  • Dong SM, Pai SI, Rha SH, Hildesheim A, Kurman RJ, Schwartz PE, Mortel R, McGowan L, Greenberg MD, Barnes WA, Sidransky D Detection and quantitation of human papillomavirus DNA in the plasma of patients with cervical carcinoma. Cancer Epidemiol Biomarkers Prev. 2002;11(1):3-6 - PMID: 11815394

  • Tseng SY, Otsuji M, Gorski K, Huang X, Slansky JE, Pai SI, Shalabi A, Shin T, Pardoll DM, Tsuchiya H B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J Exp Med. 2001;193(7):839-46 - PMID: 11283156 - PMCID: PMC2193370 - DOI: 10.1084/jem.193.7.839

  • Capone RB, Pai SI, Koch WM, Gillison ML, Danish HN, Westra WH, Daniel R, Shah KV, Sidransky D Detection and quantitation of human papillomavirus (HPV) DNA in the sera of patients with HPV-associated head and neck squamous cell carcinoma. Clin Cancer Res. 2000;6(11):4171-5 - PMID: 11106228

  • Wang TL, Ling M, Shih IM, Pham T, Pai SI, Lu Z, Kurman RJ, Pardoll DM, Wu TC Intramuscular administration of E7-transfected dendritic cells generates the most potent E7-specific anti-tumor immunity. Gene Ther. 2000;7(9):726-33 - PMID: 10822298 - DOI: 10.1038/sj.gt.3301160

  • Ji H, Wang TL, Chen CH, Pai SI, Hung CF, Lin KY, Kurman RJ, Pardoll DM, Wu TC Targeting human papillomavirus type 16 E7 to the endosomal/lysosomal compartment enhances the antitumor immunity of DNA vaccines against murine human papillomavirus type 16 E7-expressing tumors. Hum Gene Ther. 1999;10(17):2727-40 - PMID: 10584920 - DOI: 10.1089/10430349950016474

  • Pai SI, Wu GS, Ozören N, Wu L, Jen J, Sidransky D, El-Deiry WS Rare loss-of-function mutation of a death receptor gene in head and neck cancer. Cancer Res. 1998;58(16):3513-8 - PMID: 9721851

  • Trink B, Pai SI, Spunt SL, Raman V, Cairns P, Jen J, Gabrielson E, Sukumar S, Sidransky D Absence of TSG101 transcript abnormalities in human cancers. Oncogene. 1998;16(21):2815-8 - PMID: 9652749 - DOI: 10.1038/sj.onc.1201795

  • Nichols RC, Blinder J, Pai SI, Ge Q, Targoff IN, Plotz PH, Liu P Assignment of two human autoantigen genes-isoleucyl-tRNA synthetase locates to 9q21 and lysyl-tRNA synthetase locates to 16q23-q24. Genomics. 1996;36(1):210-3 - PMID: 8812440 - DOI: 10.1006/geno.1996.0449

  • Nichols RC, Pai SI, Ge Q, Targoff IN, Plotz PH, Liu P Localization of two human autoantigen genes by PCR screening and in situ hybridization--glycyl-tRNA synthetase locates to 7p15 and alanyl-tRNA synthetase locates to 16q22. Genomics. 1995;30(1):131-2 - PMID: 8595897 - DOI: 10.1006/geno.1995.0028

  • Friedmann AS, Malott KA, Memoli VA, Pai SI, Yu XM, North WG Products of vasopressin gene expression in small-cell carcinoma of the lung. Br J Cancer. 1994;69(2):260-3 - PMID: 8297723 - PMCID: PMC1968694 - DOI: 10.1038/bjc.1994.49