Naxerova, Kamila, PhD

Assistant Professor

Phone: 617-643-8446
Email: naxerova.kamila@mgh.harvard.edu
Lab: Naxerova, Kamila

Kamila Naxerova received her B.Sc. in Molecular Biotechnology with a specialization in bioinformatics from Heidelberg University in Germany, and her Ph.D. in Human Biology and Translational Medicine from Harvard University in Cambridge, MA. She completed her postdoctoral training with Dr. Stephen J. Elledge at Harvard Medical School. She is interested in using computational and high-throughput experimental approaches to elucidate the evolutionary history of human cancer. Dr. Naxerova is a recipient of a Breakthrough Award from the U.S. Department of Defense, a NextGen Grant for Transformative Cancer Research from the American Association for Cancer Research and an Early Stage Investigator MERIT Award from the National Cancer Institute.

Selected Publications (from total 32)

  • Reiter JG, Hung WT, Lee IH, Nagpal S, Giunta P, Degner S, Liu G, Wassenaar ECE, Jeck WR, Taylor MS, Farahani AA, Marble HD, Knott S, Kranenburg O, Lennerz JK, Naxerova K Lymph node metastases develop through a wider evolutionary bottleneck than distant metastases. Nat Genet. 2020;52(7):692-700 - PMID: 32451459 - PMCID: PMC7343611 - DOI: 10.1038/s41588-020-0633-2

  • Hoyer FF*, Naxerova K*, Schloss MJ, Hulsmans M, Nair AV, Dutta P, Calcagno DM, Herisson F, Anzai A, Sun Y, Wojtkiewicz G, Rohde D, Frodermann V, Vandoorne K, Courties G, Iwamoto Y, Garris CS, Williams DL, Breton S, Brown D, Whalen M, Libby P, Pittet MJ, King KR, Weissleder R, Swirski FK, Nahrendorf M Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge. Immunity. 2019;51(5):899-914.e7 - PMID: 31732166 - PMCID: PMC6892583 - DOI: 10.1016/j.immuni.2019.10.010

  • Naxerova K, Reiter JG, Brachtel E, Lennerz JK, van de Wetering M, Rowan A, Cai T, Clevers H, Swanton C, Nowak MA, Elledge SJ, Jain RK Origins of lymphatic and distant metastases in human colorectal cancer. Science. 2017;357(6346):55-60 - PMID: 28684519 - PMCID: PMC5536201 - DOI: 10.1126/science.aai8515

  • Naxerova K, Jain RK Using tumour phylogenetics to identify the roots of metastasis in humans. Nat Rev Clin Oncol. 2015;12(5):258-72 - PMID: 25601447 - DOI: 10.1038/nrclinonc.2014.238

  • Naxerova K, Brachtel E, Salk JJ, Seese AM, Power K, Abbasi B, Snuderl M, Chiang S, Kasif S, Jain RK Hypermutable DNA chronicles the evolution of human colon cancer. Proc Natl Acad Sci U S A. 2014;111(18):E1889-98 - PMID: 24753616 - PMCID: PMC4020055 - DOI: 10.1073/pnas.1400179111

  • Naxerova K, Bult CJ, Peaston A, Fancher K, Knowles BB, Kasif S, Kohane IS Analysis of gene expression in a developmental context emphasizes distinct biological leitmotifs in human cancers. Genome Biol. 2008;9(7):R108 - PMID: 18611264 - PMCID: PMC2530866 - DOI: 10.1186/gb-2008-9-7-r108

  • Otu HH*, Naxerova K*, Ho K, Can H, Nesbitt N, Libermann TA, Karp SJ Restoration of liver mass after injury requires proliferative and not embryonic transcriptional patterns. J Biol Chem. 2007;282(15):11197-204 - PMID: 17227769 - DOI: 10.1074/jbc.M608441200