Pivovarov, Misha, MS
Director, Research Informatics Core
A foremost challenge for informatics departments is the integration of information across disciplines. We are in the process of developing a Molecular Imaging Portal (MIPortal) system that will enable combination of data sets - imaging, genomics, proteomics, histology, and results of their analysis.
An experimental PACS system with high-capacity storage is in the core of our IT infrastructure. Images acquired on all imaging modalities are associated with other experimental data for persistent storage and distribution via Web Interface. Investigators will be able to review images, manage studies and download full data sets for post-processing analysis.
The Information Technology group is responsible for managing technology infrastructure and designing new information system architecture to support molecular imaging research.
Another area of our work is focused on developing post-processing algorithms and tools. CMIR_Image is an image display and analysis suite developed by our group. It offers a range of flexible tools for the visualization and quantization of a wide range of image types and formats relevant to biological imaging.
Publications
Pathania D, Landeros C, Rohrer L, D’Agostino V, Hong S, Degani I, Avila-Wallace M, Pivovarov M, Randall T, Weissleder R, Lee H, Im H, Castro CM Point-of-care cervical cancer screening using deep learning-based microholography. Theranostics. 2019;9(26):8438-8447 - PMID: 31879529 - PMCID: PMC6924258 - DOI: 10.7150/thno.37187
Im H, Pathania D, McFarland PJ, Sohani AR, Degani I, Allen M, Coble M, Kilcoyne A, Hong S, Rohrer L, Abramson JS, Dryden-Peterson S, Fexon L, Pivovarov M, Chabner B, Lee H, Castro CM, Weissleder R Design and clinical validation of a point-of-care device for the diagnosis of lymphoma via contrast- enhanced microholography and machine learning. Nat Biomed Eng. 2018;2(9):666-674 - PMID: 30555750 - PMCID: PMC6291220 - DOI: 10.1038/s41551-018-0265-3
Global Cardiovascular Magnetic Resonance Registry (GCMR) Investigators, Kwong RY, Petersen SE, Schulz-Menger J, Arai AE, Bingham SE, Chen Y, Choi YL, Cury RC, Ferreira VM, Flamm SD, Steel K, Bandettini WP, Martin ET, Nallamshetty L, Neubauer S, Raman SV, Schelbert EB, Valeti US, Cao JJ, Reichek N, Young AA, Fexon L, Pivovarov M, Ferrari VA, Simonetti OP The global cardiovascular magnetic resonance registry (GCMR) of the society for cardiovascular magnetic resonance (SCMR): its goals, rationale, data infrastructure, and current developments. J Cardiovasc Magn Reson. 2017;19(1):23 - PMID: 28187739 - PMCID: PMC5303267 - DOI: 10.1186/s12968-016-0321-7
Pathania D*, Im H*, Kilcoyne A, Sohani AR, Fexon L, Pivovarov M, Abramson JS, Randall TC, Chabner BA, Weissleder R, Lee H, Castro CM Holographic Assessment of Lymphoma Tissue (HALT) for Global Oncology Field Applications. Theranostics. 2016;6(10):1603-10 - PMID: 27446494 - PMCID: PMC4955059 - DOI: 10.7150/thno.15534
Song J, Leon Swisher C, Im H, Jeong S, Pathania D, Iwamoto Y, Pivovarov M, Weissleder R, Lee H Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography. Sci Rep. 2016;6:24681 - PMID: 27098438 - PMCID: PMC4838824 - DOI: 10.1038/srep24681
Im H, Castro CM, Shao H, Liong M, Song J, Pathania D, Fexon L, Min C, Avila-Wallace M, Zurkiya O, Rho J, Magaoay B, Tambouret RH, Pivovarov M, Weissleder R*, Lee H* Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone. Proc Natl Acad Sci U S A. 2015;112(18):5613-8 - PMID: 25870273 - PMCID: PMC4426451 - DOI: 10.1073/pnas.1501815112
Lee S, Vinegoni C, Feruglio PF, Fexon L, Gorbatov R, Pivovarov M, Sbarbati A, Nahrendorf M, Weissleder R Real-time in vivo imaging of the beating mouse heart at microscopic resolution. Nat Commun. 2012;3:1054 - PMID: 22968700 - PMCID: PMC3622400 - DOI: 10.1038/ncomms2060
Nahrendorf M, Keliher E, Marinelli B, Waterman P, Feruglio PF, Fexon L, Pivovarov M, Swirski FK, Pittet MJ, Vinegoni C, Weissleder R Hybrid PET-optical imaging using targeted probes. Proc Natl Acad Sci U S A. 2010;107(17):7910-5 - PMID: 20385821 - PMCID: PMC2867879 - DOI: 10.1073/pnas.0915163107
Vinegoni C, Fexon L, Fumene Feruglio P, Pivovarov M, Figueiredo JL, Nahrendorf M, Pozzo A, Sbarbati A, Weissleder R High throughput transmission optical projection tomography using low cost graphics processing unit. Opt Express. 2009;17(25):22320-22332 - PMID: 20052155 - PMCID: PMC2805020 - DOI: 10.1364/OE.17.022320
Duchrow T, Shtatland T, Guettler D, Pivovarov M, Kramer S, Weissleder R Enhancing navigation in biomedical databases by community voting and database-driven text classification. BMC Bioinformatics. 2009;10(1):317 - PMID: 19799796 - PMCID: PMC2768718 - DOI: 10.1186/1471-2105-10-317
Vinegoni C, Razansky D, Figueiredo JL, Fexon L, Pivovarov M, Nahrendorf M, Ntziachristos V, Weissleder R Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging. J Vis Exp. 2009;28:1389 - PMID: 19578329 - PMCID: PMC2794886 - DOI: 10.3791/1389
Shtatland T, Guettler D, Kossodo M, Pivovarov M, Weissleder R PepBank - a database of peptides based on sequence text mining and public peptide data sources. BMC Bioinformatics. 2007;8(1):280 - PMID: 17678535 - PMCID: PMC1976427 - DOI: 10.1186/1471-2105-8-280
Pivovarov M, Bhandary G, Mahmood U, Zahlmann G, Naraghi M, Weissleder R MIPortal: A High Capacity Server for Molecular Imaging Research. Mol Imaging. 2005;4(4):425-31 - PMID: 16285904 - DOI: 10.2310/7290.2005.05136
Goldberg M, Gazelle G, Boland G, Hahn P, Mayo-Smith W, Pivovarov M, Halpern E, Wittenberg J Focal hepatic lesions: effect of three-dimensional wavelet compression on detection at CT. Radiology. 1997;202:159-65 - PMID: 8988206 - DOI: 10.1148/radiology.202.1.8988206
Goldberg M, Pivovarov M, Mayo-Smith W, Bhalla M, Blickman J, Bramson R, Boland G, Llewellyn H, Halpern E Application of wavelet compression to digitized radiographs. AJR Am J Roentgenol. 1994;163:463-8 - PMID: 8037051 - DOI: 10.2214/ajr.163.2.8037051