Dubach, John, PhD

Assistant Professor

Phone:
Email: dubach.john@mgh.harvard.edu
Lab: Dubach, John

Publications

  • Gopal AA, Fernandez B, Delano J, Weissleder R, Dubach JM PARP trapping is governed by the PARP inhibitor dissociation rate constant. Cell Chem Biol. 2024;31(7):1373-1382.e10 - PMID: 38262416 - PMCID: PMC11259578 - DOI: 10.1016/j.chembiol.2023.12.019

  • Rodell CB, Baldwin P, Fernandez B, Weissleder R, Sridhar S, Dubach JM Quantification of Cellular Drug Biodistribution Addresses Challenges in Evaluating in vitro and in vivo Encapsulated Drug Delivery. Adv Ther (Weinh). 2020;4(3):ePub - PMID: 33997266 - PMCID: PMC8114878 - DOI: 10.1002/adtp.202000125

  • Cuccarese MF, Dubach JM, Pfirschke C, Engblom C, Garris C, Miller MA, Pittet MJ, Weissleder R Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging. Nat Commun. 2017;8:14293 - PMID: 28176769 - PMCID: PMC5309815 - DOI: 10.1038/ncomms14293

  • Dubach JM, Kim E, Yang K, Cuccarese M, Giedt RJ, Meimetis LG, Vinegoni C, Weissleder R Quantitating drug-target engagement in single cells in vitro and in vivo. Nat Chem Biol. 2016;13(2):168-173 - PMID: 27918558 - PMCID: PMC5630128 - DOI: 10.1038/nchembio.2248

  • Vinegoni C, Dubach JM, Feruglio PF, Weissleder R Two-Photon Fluorescence Anisotropy Microscopy for Imaging and Direct Measurement of Intracellular Drug Target Engagement. IEEE J Sel Top Quant. 2016;22 (3):6801607 - PMID: 27440991 - PMCID: PMC4946648 - DOI: 10.1109/JSTQE.2015.2501384

  • Kim E, Yang K, Kohler R, Dubach JM, Mikula H, Weissleder R Optimized Near-IR fluorescent agents for in vivo imaging of Btk expression. Bioconjug Chem. 2015;26(8):1513-1518 - PMID: 26017814 - PMCID: PMC4772718 - DOI: 10.1021/acs.bioconjchem.5b00152

  • Vinegoni C, Dubach JM, Thurber GM, Miller MA, Mazitschek R, Weissleder R Advances in measuring single-cell pharmacokinetics and pharmacology in vivo. Drug Discov Today. 2015;20(9):1087-92 - PMID: 26024776 - PMCID: PMC4567932 - DOI: 10.1016/j.drudis.2015.05.011

  • Dubach JM, Vinegoni C, Weissleder R Steady state anisotropy two-photon microscopy resolves multiple, spectrally similar fluorophores, enabling in vivo multilabel imaging. Opt Lett. 2014;39(15):4482-4485 - PMID: 25078208 - PMCID: PMC4341989 - DOI: 10.1364/OL.39.004482

  • Dubach JM, Vinegoni C, Mazitschek R, Fumene Feruglio P, Cameron LA, Weissleder R In vivo imaging of specific drug-target binding at subcellular resolution. Nat Commun. 2014;5:3946 - PMID: 24867710 - PMCID: PMC4362617 - DOI: 10.1038/ncomms4946