Dubach, John, PhD

Assistant Professor

Phone:
Email: dubach.john@mgh.harvard.edu
Lab: Weissleder, Ralph

Publications

  • Cuccarese MF, Dubach JM, Pfirschke C, Engblom C, Garris C, Miller MA, Pittet MJ, Weissleder R Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging. Nat Commun. 2017;8:14293 - PMID: 28176769 - PMCID: PMC5309815 - DOI: 10.1038/ncomms14293

  • Dubach JM, Kim E, Yang K, Cuccarese M, Giedt RJ, Meimetis LG, Vinegoni C, Weissleder R Quantitating drug-target engagement in single cells in vitro and in vivo. Nat Chem Biol. 2017;13(2):168-173 - PMID: 27918558 - PMCID: PMC5630128 - DOI: 10.1038/nchembio.2248

  • Vinegoni C, Dubach JM, Feruglio PF, Weissleder R Two-Photon Fluorescence Anisotropy Microscopy for Imaging and Direct Measurement of Intracellular Drug Target Engagement. IEEE J Sel Top Quant. 2016;22 (3):6801607 - PMID: 27440991 - PMCID: PMC4946648 - DOI: 10.1109/JSTQE.2015.2501384

  • Kim E, Yang K, Kohler R, Dubach JM, Mikula H, Weissleder R Optimized Near-IR fluorescent agents for in vivo imaging of Btk expression. Bioconjug Chem. 2015;26(8):1513-1518 - PMID: 26017814 - PMCID: PMC4772718 - DOI: 10.1021/acs.bioconjchem.5b00152

  • Vinegoni C, Dubach JM, Thurber GM, Miller MA, Mazitschek R, Weissleder R Advances in measuring single-cell pharmacokinetics and pharmacology in vivo. Drug Discov Today. 2015;20(9):1087-92 - PMID: 26024776 - PMCID: PMC4567932 - DOI: 10.1016/j.drudis.2015.05.011

  • Dubach JM, Vinegoni C, Weissleder R Steady state anisotropy two-photon microscopy resolves multiple, spectrally similar fluorophores, enabling in vivo multilabel imaging. Opt Lett. 2014;39(15):4482-4485 - PMID: 25078208 - PMCID: PMC4341989 - DOI: 10.1364/OL.39.004482

  • Dubach JM, Vinegoni C, Mazitschek R, Fumene Feruglio P, Cameron LA, Weissleder R In vivo imaging of specific drug-target binding at subcellular resolution. Nat Commun. 2014;5:3946 - PMID: 24867710 - PMCID: PMC4362617 - DOI: 10.1038/ncomms4946