Brown, Dennis, PhD
Dennis Brown is a Ph. D. cell biologist who specializes in the use of state-of-the art fluorescence imaging and electron microscopy techniques to follow and dissect physiologically-relevant membrane protein trafficking events in epithelial and non-epithelial cells. He serves as the Associate Director of the CSB and the Director of the MGH Program in Membrane Biology (PMB) which uses use state of the art technologies in the pursuit of important biological questions at the system level. He became Professor of Medicine at Harvard in 2001 and has been at MGH since 1985.
Cellular uptake of nanoparticles: journey inside the cell.
Electrical Conduction in the Heart
Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq.
Extracellular Adenosine Stimulates Vacuolar ATPase-Dependent Proton Secretion in Medullary Intercalated Cells.
Characterization and Correction of Olfactory Deficits in Kidney Disease.
The ammonia transporter RhCG modulates urinary acidification by interacting with the vacuolar proton-ATPases in renal intercalated cells.
APS: The Times They Are A-Changin'.
Direct interaction of ezrin and AQP2 and its role in AQP2 trafficking.
Protein phosphatase 2C (PP2C) is responsible for VP-induced dephosphorylation of AQP2 serine 261.
The Discovery of Water Channels (Aquaporins).
The V-ATPase is expressed in the choroid plexus and mediates cAMP-induced intracellular pH alterations.