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Brown, Dennis, PhD

Dennis_brown
Phone: 617-726-5665
Email: Brown.Dennis@mgh.harvard.edu
Lab: Brown, Dennis

Research

Dennis Brown is a Ph. D. cell biologist who specializes in the use of state-of-the art fluorescence imaging and electron microscopy techniques to follow and dissect physiologically-relevant membrane protein trafficking events in epithelial and non-epithelial cells. He serves as the Associate Director of the CSB and the Director of the MGH Program in Membrane Biology (PMB) which uses use state of the art technologies in the pursuit of important biological questions at the system level. He became Professor of Medicine at Harvard in 2001 and has been at MGH since 1985.

Publications

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Brown D, Breton S, Ausiello DA, Marshansky V
Sensing, Signaling and Sorting Events in Kidney Epithelial Cell Physiology.
Traffic. 2009;10(3):275-84 - PMID: 19170982 - PMCID: PMC2896909 - DOI: 10.1111/j.1600-0854.2008.00867.x
Belleannee C, Da Silva N, Shum WW, Marsolais M, Laprade R, Brown D, Breton S
Segmental Expression of the Bradykinin Type 2 Receptor in Rat Efferent Ducts and Epididymis and Its Role in the Regulation of Aquaporin 9.
Biol Reprod. 2009;80(1):134-43 - PMID: 18829705 - PMCID: PMC2804812 - DOI: 10.1095/biolreprod.108.070797 - Cover
Bouley R, Palomino Z, Tang SS, Nunes P, Kobori H, Lu HA, Shum WW, Sabolic I, Brown D, Ingelfinger JR, Jung FF
Angiotensin II and Hypertonicity Modulate Proximal Tubular Aquaporin 1 (AQP1) Expression.
Am J Physiol Renal Physiol. 2009;297(6):F1575-86 - PMID: 19776169 - PMCID: PMC2801332 - DOI: 10.1152/ajprenal.90762.2008
Van Hoek AN, Bouley R, Lu YX, Silberstein CM, Brown D, Wax MB, Patil RV
Vasopressin-induced differential stimulation of AQP4 splice variants regulates the in-membrane assembly of orthogonal arrays.
Am J Physiol Renal Physiol. 2009;296(6):F1396-404 - PMID: 19297454 - PMCID: PMC2692439 - DOI: 10.1152/ajprenal.00018.2009
Pastor-Soler NM, Fisher JS, Sharpe R, Hill E, Van Hoek A, Brown D, Breton S
Aquaporin 9 expression in the developing rat epididymis is modulated by steroid hormones.
Reproduction. 2009;139(3):613-21 - PMID: 19948840 - PMCID: PMC3773695 - DOI: 10.1530/REP-09-0284
Brown D, Paunescu TG, Breton S, Marshansky V
Regulation of the V-ATPase in kidney epithelial cells: dual role in acid-base homeostasis and vesicle trafficking.
J Exp Biol. 2009;212(Pt 11):1762-72 - PMID: 19448085 - PMCID: PMC2683016 - DOI: 10.1242/jeb.028803 - Cover
Shum WW, Da Silva N, Brown D, Breton S
Regulation of luminal acidification in the male reproductive tract via cell-cell crosstalk.
J Exp Biol. 2009;212(Pt 11):1753-61 - PMID: 19448084 - PMCID: PMC2683015 - DOI: 10.1242/jeb.027284 - Cover
Shum WW, Da Silva N, McKee M, Smith PJ, Brown D, Breton S
Transepithelial Projections from Basal Cells are Luminal Sensors in Pseudostratified Epithelia
Cell. 2008;135:1108-17 - PMID: 19070580 - PMCID: PMC2646085 - DOI: 10.1016/j.cell.2008.10.020
Russo LM, Sandoval RM, Campos SB, Molitoris BA, Comper WD, Brown D
Impaired Tubular Uptake Explains Albuminuria in Early Diabetic Nephropathy.
J Am Soc Nephrol. 2008;20(3):489-94 - PMID: 19118149 - PMCID: PMC2653682 - DOI: 10.1681/ASN.2008050503
Miller RL, Lucero OM, Riemondy KA, Baumgartner BK, Brown D, Breton S, Nelson RD
The V-ATPase B1-subunit promoter drives expression of Cre recombinase in intercalated cells of the kidney.
Kidney Int. 2008;75(4):435-9 - PMID: 19052537 - PMCID: PMC4301582 - DOI: 10.1038/ki.2008.569
Zalyapin EA, Bouley R, Hasler U, Vilardaga JP, Lin HY, Brown D, Ausiello DA
Effects of the renal medullary pH and ionic environment on vasopressin binding and signaling.
Kidney Int. 2008;74(12):1557-67 - PMID: 18813286 - PMCID: PMC3730289 - DOI: 10.1038/ki.2008.412
Hasler U, Nunes P, Bouley R, Lu HA, Matsuzaki T, Brown D
Acute hypertonicity alters aquaporin-2 trafficking and induces a MAP kinase-dependent accumulation at the plasma membrane of renal epithelial cells.
J Biol Chem. 2008;283(39):26643-61 - PMID: 18664568 - PMCID: PMC2546545 - DOI: 10.1074/jbc.M801071200
Russo LM, Brown D, Lin HY
The soluble transforming growth factor-beta receptor: Advantages and applications.
Int J Biochem Cell B. 2008;41(3):472-6 - PMID: 18339576 - DOI: 10.1016/j.biocel.2008.01.026
Brown D, Hasler U, Nunes P, Bouley R, Lu H
Phosphorylation events and the modulation of aquaporin 2 cell surface expression.
Curr Opin Nephrol Hypertens. 2008;17(5):491-8 - PMID: 18695390 - PMCID: PMC3774073 - DOI: 10.1097/MNH.0b013e3283094eb1
Nunes P, Hasler U, McKee M, Lu HA, Bouley R, Brown D
A fluorimetry-based ssYFP secretion assay to monitor vasopressin-induced exocytosis in LLC-PK1 cells expressing aquaporin-2 (AQP2).
Am J Physiol Cell Physiol. 2008;295(6):C1476-87 - PMID: 18799651 - PMCID: PMC2603565 - DOI: 10.1152/ajpcell.00344.2008
Paunescu TG, Jones AC, Tyszkowski R, Brown D
V-ATPase expression in the mouse olfactory epithelium.
Am J Physiol Cell Physiol. 2008;295(4):C923-30 - PMID: 18667600 - PMCID: PMC2575830 - DOI: 10.1152/ajpcell.00237.2008
Lu HA, Matsuzaki T, Bouley R, Hasler U, Qin Q, Brown D
The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells.
Am J Physiol Renal Physiol. 2008;295(1):F290-4 - PMID: 18434387 - PMCID: PMC2494506 - DOI: 10.1152/ajprenal.00072.2008
Brown D
Aquaporins and vasopressin signaling in kidney health and disease: introduction.
Semin Nephrol. 2008;28:215-6 - PMID: 18519082 - DOI: 10.1016/j.semnephrol.2008.03.001
Bouley R, Hasler U, Lu HA, Nunes P, Brown D
Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidus.
Semin Nephrol. 2008;28:266-78 - PMID: 18519087 - PMCID: PMC2494582 - DOI: 10.1016/j.semnephrol.2008.03.010
Russo LM, Sandoval RM, Brown D, Molitoris BA, Comper WD
Response to ''Albumin concentration in the Bowman's capsule: Multiphoton microscopy vs micropuncture technique''
Kidney Int. 2007;72:1411 - PMID: 18004315
Russo LM, Sandoval RM, Brown D, Molitoris BA, Comper WD
Response to ''On the origin of albuminuria''
Kidney Int. 2007;72:1409-10 - PMID: 18004312
Russo LM, Sandoval RM, Brown D, Molitoris BA, Comper WD
Controversies in nephrology: Response to ''renal albumin handling, facts, and artifacts''
Kidney Int. 2007;72(10):1195-7 - PMID: 17851467 - DOI: 10.1038/sj.ki.5002528
Russo LM, Sandoval RM, McKee M, Osicka TM, Collins AB, Brown D, Molitoris BA, Comper WD
The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: retrieval is disrupted in nephrotic states.
Kidney Int. 2007;71(6):504-13 - PMID: 17228368 - DOI: 10.1038/sj.ki.5002041
Russo LM, del Re E, Brown D, Lin HY
Evidence for a role of transforming growth factor (TGF)-beta1 in the induction of postglomerular albuminuria in diabetic nephropathy: amelioration by soluble TGF-beta type II receptor.
Diabetes. 2007;56(2):380-8 - PMID: 17259382 - DOI: 10.2337/db06-1018
Pietrement C, Da Silva N, Silberstein C, James M, Marsolais M, Van Hoek A, Brown D, Pastor-Soler N, Ameen N, Laprade R, Ramesh V, Breton S
Role of NHERF1, CFTR and cAMP in the regulation of aquaporin 9
J Biol Chem. 2007;283:2986-96 - PMID: 18055461 - DOI: 10.1074/jbc.M704678200
Lu HA, Sun TX, Matsuzaki T, Yi XH, Eswara J, Bouley R, McKee M, Brown D
Heat shock protein 70 interacts with aquaporin-2 (AQP2) and regulates its trafficking.
J Biol Chem. 2007;282(39):28721-32 - PMID: 17636261 - DOI: 10.1074/jbc.M611101200
Da Silva N, Shum WW, El-Annan J, Paunescu TG, McKee M, Smith PJ, Brown D, Breton S
Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit.
Am J Physiol Cell Physiol. 2007;293(1):C199-210 - PMID: 17392376 - DOI: 10.1152/ajpcell.00596.2006 - Cover
Paunescu TG, Russo LM, Da Silva N, Kovacikova J, Mohebbi N, Van Hoek AN, McKee M, Wagner CA, Breton S, Brown D
Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice.
Am J Physiol Renal Physiol. 2007;293(6):F1915-26 - PMID: 17898041 - DOI: 10.1152/ajprenal.00160.2007
Paunescu TG, Da Silva N, Russo LM, McKee M, Lu HA, Breton S, Brown D
Association Of Soluble Adenylyl Cyclase (sAC) With The V-ATPase In Renal Epithelial Cells.
Am J Physiol Renal Physiol. 2007;294(1):F130-8 - PMID: 17959750 - DOI: 10.1152/ajprenal.00406.2007
Yi X, Bouley R, Lin HY, Bechoua S, Sun TX, Del Re E, Shioda T, Raychowdhury MK, Lu HA, Abou-Samra AB, Brown D, Ausiello DA
Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R.
Am J Physiol Renal Physiol. 2007;292(5):F1303-13 - PMID: 17287200 - DOI: 10.1152/ajprenal.00441.2005
Hurtado-Lorenzo A, Skinner M, El Annan J, Futai M, Sun-Wada GH, Bourgoin S, Casanova J, Wildeman A, Bechoua S, Ausiello DA, Brown D, Marshansky V
V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway.
Nat Cell Biol. 2006;8(2):124-36 - PMID: 16415858 - DOI: 10.1038/ncb1348
Da Silva N, Pietrement C, Brown D, Breton S
Segmental and cellular expression of aquaporins in the male excurrent duct.
Biochim Biophys Acta. 2006;1758(8):1025-33 - PMID: 16935257 - DOI: 10.1016/j.bbamem.2006.06.026
Breton S, Brown D
New insights into the regulation of V-ATPase-dependent proton secretion.
Am J Physiol Renal Physiol. 2006;292(1):F1-10 - PMID: 17032935 - DOI: 10.1152/ajprenal.00340.2006
Bouley R, Hawthorn G, Russo L, Lin H, Ausiello D, Brown D
Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment.
Biol Cell. 2006;98(4):215-32 - PMID: 16563128 - DOI: 10.1042/BC20040054
Reiser J, Polu KR, Moller CC, Kenlan P, Altintas MM, Wei C, Faul C, Herbert S, Villegas I, Avila-Casado C, McGee M, Sugimoto H, Brown D, Kalluri R, Mundel P, Smith PL, Clapham DE, Pollak MR
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.
Nat Genet. 2005;37(7):739-44 - PMID: 15924139 - PMCID: PMC1360984 - DOI: 10.1038/ng1592
Finberg KE, Wagner CA, Bailey MA, Paunescu TG, Breton S, Brown D, Giebisch G, Geibel JP, Lifton RP
The B1-subunit of the H(+) ATPase is required for maximal urinary acidification.
Proc Natl Acad Sci U S A. 2005;102(38):13616-21 - PMID: 16174750 - PMCID: PMC1224669 - DOI: 10.1073/pnas.0506769102
Beaulieu V, Da Silva N, Pastor-Soler N, Brown CR, Smith PJ, Brown D, Breton S
Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling.
J Biol Chem. 2005;280(9):8452-63 - PMID: 15591047 - DOI: 10.1074/jbc.M412750200
Pietrement C, Sun-Wada GH, Silva ND, McKee M, Marshansky V, Brown D, Futai M, Breton S
Distinct expression patterns of different subunit isoforms of the V-ATPase in the rat epididymis.
Biol Reprod. 2005;74(1):185-94 - PMID: 16192400 - DOI: 10.1095/biolreprod.105.043752
Da Silva N, Silberstein C, Beaulieu V, Pietrement C, Van Hoek AN, Brown D, Breton S
Postnatal expression of aquaporins in epithelial cells of the rat epididymis.
Biol Reprod. 2005;74(2):427-38 - PMID: 16221990 - DOI: 10.1095/biolreprod.105.044735
Sabolic I, Herak-Kramberger CM, Antolovic R, Breton S, Brown D
Loss of basolateral invaginations in proximal tubules of cadmium-intoxicated rats is independent of microtubules and clathrin.
Toxicology. 2005;218(2-3):149-63 - PMID: 16288946 - DOI: 10.1016/j.tox.2005.10.009
Lisi S, Botta R, Pinchera A, Collins AB, Refetoff S, Arvan P, Bu G, Grasso L, Marshansky V, Bechoua S, Hurtado-Lorenzo A, Marcocci C, Brown D, McCluskey RT, MarinĂ² M
Defective thyroglobulin storage in LDL receptor-associated protein-deficient mice.
Am J Physiol Cell Physiol. 2005;290(4):C1160-7 - PMID: 16306127 - DOI: 10.1152/ajpcell.00382.2005
Bouley R, Lin HY, Raychowdhury MK, Marshansky V, Brown D, Ausiello DA
Downregulation of the vasopressin type 2 receptor after vasopressin-induced internalization: involvement of a lysosomal degradation pathway.
Am J Physiol Cell Physiol. 2005;288(6):C1390-401 - PMID: 15677378 - DOI: 10.1152/ajpcell.00353.2004
Miller RL, Zhang P, Smith M, Beaulieu V, Paunescu TG, Brown D, Breton S, Nelson RD
V-ATPase B1-subunit promoter drives expression of EGFP in intercalated cells of kidney, clear cells of epididymis and airway cells of lung in transgenic mice.
Am J Physiol Cell Physiol. 2005;288(5):C1134-44 - PMID: 15634743 - DOI: 10.1152/ajpcell.00084.2004
Bouley R, Pastor-Soler N, Cohen O, McLaughlin M, Breton S, Brown D
Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra).
Am J Physiol Renal Physiol. 2005;288(6):F1103-12 - PMID: 15644488 - DOI: 10.1152/ajprenal.00337.2004
Bouley R, Hawthorn G, Russo L, Lin HY, Ausiello D, Brown D
Aquaporin 2 (AQP2) and vasopressin receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in "endocytosis-resistant" membrane domains after vasopressin treatment.
Abdom Imaging. 2005;:ePub - PMID: 16104839
Paunescu TG, Da Silva N, Marshansky V, McKee M, Breton S, Brown D
Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis.
Am J Physiol Cell Physiol. 2004;287(1):C149-62 - PMID: 15013950 - DOI: 10.1152/ajpcell.00464.2003
Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, Geibel JP
Renal vacuolar H+-ATPase.
2004;84(4):1263-314 - PMID: 15383652 - DOI: 10.1152/physrev.00045.2003
Wagner CA, L
A rapid enzymatic method for the isolation of defined kidney tubule fragments from mouse.
Pflug Arch Eur J Phy. 2003;446(5):623-32 - PMID: 12748863 - DOI: 10.1007/s00424-003-1082-3
Pastor-Soler N, Beaulieu V, Litvin TN, Da Silva N, Chen Y, Brown D, Buck J, Levin LR, Breton S
Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling.
J Biol Chem. 2003;278(49):49523-9 - PMID: 14512417 - PMCID: PMC3652382 - DOI: 10.1074/jbc.M309543200
El-Annan J, Brown D, Breton S, Bourgoin S, Ausiello DA, Marshansky V
Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situ.
Am J Physiol Cell Physiol. 2003;286(4):C768-78 - PMID: 14684384 - DOI: 10.1152/ajpcell.00250.2003
Isnard-Bagnis C, Da Silva N, Beaulieu V, Yu AS, Brown D, Breton S
Detection of ClC-3 and ClC-5 in epididymal epithelium: immunofluorescence and RT-PCR after LCM.
Am J Physiol Cell Physiol. 2003;284(1):C220-32 - PMID: 12475763 - DOI: 10.1152/ajpcell.00374.2001
Lu H, Sun TX, Bouley R, Blackburn K, McLaughlin M, Brown D
Inhibition of endocytosis causes phosphorylation (S256)-independent plasma membrane accumulation of AQP2.
Am J Physiol Renal Physiol. 2003;286(2):F233-43 - PMID: 14519593 - DOI: 10.1152/ajprenal.00179.2003
van Balkom BW, van Raak M, Breton S, Pastor-Soler N, Bouley R, van der Sluijs P, Brown D, Deen PM
Hypertonicity is involved in redirecting the aquaporin-2 water channel into the basolateral, instead of the apical, plasma membrane of renal epithelial cells.
J Biol Chem. 2002;278(2):1101-7 - PMID: 12374804 - DOI: 10.1074/jbc.M207339200
Pastor-Soler N, Isnard-Bagnis C, Herak-Kramberger C, Sabolic I, Van Hoek A, Brown D, Breton S
Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens.
Biol Reprod. 2002;66(6):1716-22 - PMID: 12021052 - DOI: 10.1095/biolreprod66.6.1716
Marshansky V, Ausiello DA, Brown D
Physiological importance of endosomal acidification: potential role in proximal tubulopathies.
Curr Opin Nephrol Hypertens. 2002;11(5):527-37 - PMID: 12187318
Zharkikh L, Zhu X, Stricklett PK, Kohan DE, Chipman G, Breton S, Brown D, Nelson RD
Renal principal cell-specific expression of green fluorescent protein in transgenic mice.
Am J Physiol Renal Physiol. 2002;283(6):F1351-64 - PMID: 12426236 - DOI: 10.1152/ajprenal.0224.2001
Breton S, Inoue T, Knepper MA, Brown D
Antigen retrieval reveals widespread basolateral expression of syntaxin 3 in renal epithelia.
Am J Physiol Renal Physiol. 2002;282(3):F523-9 - PMID: 11832435 - DOI: 10.1152/ajprenal.00128.2001
Maranda B, Brown D, Bourgoin S, Casanova JE, Vinay P, Ausiello DA, Marshansky V
Intra-endosomal pH-sensitive recruitment of the Arf-nucleotide exchange factor ARNO and Arf6 from cytoplasm to proximal tubule endosomes.
J Biol Chem. 2001;276(21):18540-50 - PMID: 11278939 - DOI: 10.1074/jbc.M011577200
Pastor-Soler N, Bagnis C, Sabolic I, Tyszkowski R, McKee M, Van Hoek A, Breton S, Brown D
Aquaporin 9 expression along the male reproductive tract.
Biol Reprod. 2001;65(2):384-93 - PMID: 11466204 - DOI: 10.1095/biolreprod65.2.384
Herak-Kramberger CM, Breton S, Brown D, Kraus O, Sabolic I
Distribution of the vacuolar H+ atpase along the rat and human male reproductive tract.
Biol Reprod. 2001;64(6):1699-707 - PMID: 11369598 - DOI: 10.1095/biolreprod64.6.1699
Bagnis C, Marshansky V, Breton S, Brown D
Remodeling the cellular profile of collecting ducts by chronic carbonic anhydrase inhibition.
Am J Physiol Renal Physiol. 2001;280(3):F437-48 - PMID: 11181405 - DOI: 10.1152/ajprenal.2001.280.3.F437
Tekirian TL, Merriam DE, Marshansky V, Miller J, Crowley AC, Chan H, Ausiello D, Brown D, Buxbaum JD, Xia W, Wasco W
Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments.
Brain Res Mol Brain Res. 2001;96(1-2):14-20 - PMID: 11731004 - DOI: 10.1016/s0169-328x(01)00250-9
Choukroun GJ, Marshansky V, Gustafson CE, McKee M, Hajjar RJ, Rosenzweig A, Brown D, Bonventre JV
Cytosolic phospholipase A(2) regulates golgi structure and modulates intracellular trafficking of membrane proteins.
J Clin Invest. 2000;106(8):983-93 - PMID: 11032858 - PMCID: PMC314339 - DOI: 10.1172/JCI8914
Bouley R, Breton S, Sun T, McLaughlin M, Nsumu NN, Lin HY, Ausiello DA, Brown D
Nitric oxide and atrial natriuretic factor stimulate cGMP-dependent membrane insertion of aquaporin 2 in renal epithelial cells.
J Clin Invest. 2000;106(9):1115-26 - PMID: 11067864 - PMCID: PMC301414 - DOI: 10.1172/JCI9594
Brown D, Breton S
Sorting proteins to their target membranes.
Kidney Int. 2000;57(3):816-24 - PMID: 10720934 - DOI: 10.1046/j.1523-1755.2000.00920.x
Breton S, Wiederhold T, Marshansky V, Nsumu NN, Ramesh V, Brown D
The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells.
J Biol Chem. 2000;275(24):18219-24 - PMID: 10748165 - DOI: 10.1074/jbc.M909857199
Sullivan BM, Harrison-Lavoie KJ, Marshansky V, Lin HY, Kehrl JH, Ausiello DA, Brown D, Druey KM
RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.
Mol Biol Cell. 2000;11(9):3155-68 - PMID: 10982407 - PMCID: PMC14982 - DOI: 10.1091/mbc.11.9.3155
Herak-Kramberger CM, Sabolić I, Blanusa M, Smith PJ, Brown D, Breton S
Cadmium inhibits vacuolar H(+)ATPase-mediated acidification in the rat epididymis.
Biol Reprod. 2000;63(2):599-606 - PMID: 10906070 - DOI: 10.1095/biolreprod63.2.599
Stevens AL, Breton S, Gustafson CE, Bouley R, Nelson RD, Kohan DE, Brown D
Aquaporin 2 is a vasopressin-independent, constitutive apical membrane protein in rat vas deferens.
Am J Physiol Cell Physiol. 2000;278(4):C791-802 - PMID: 10751327 - DOI: 10.1152/ajpcell.2000.278.4.C791
Silver RB, Breton S, Brown D
Potassium depletion increases proton pump (H(+)-ATPase) activity in intercalated cells of cortical collecting duct.
Am J Physiol Renal Physiol. 2000;279(1):F195-202 - PMID: 10894802 - DOI: 10.1152/ajprenal.2000.279.1.F195
Breton S, Nsumu NN, Galli T, Sabolic I, Smith PJ, Brown D
Tetanus toxin-mediated cleavage of cellubrevin inhibits proton secretion in the male reproductive tract.
Am J Physiol Renal Physiol. 2000;278(5):F717-25 - PMID: 10807583 - DOI: 10.1152/ajprenal.2000.278.5.F717
Brown D, Breton S
H(+)V-ATPase-dependent luminal acidification in the kidney collecting duct and the epididymis/vas deferens: vesicle recycling and transcytotic pathways.
J Exp Biol. 2000;203(Pt 1):137-45 - PMID: 10600682
Sabolić I, Herak-Kramberger CM, Breton S, Brown D
Na/K-ATPase in intercalated cells along the rat nephron revealed by antigen retrieval.
J Am Soc Nephrol. 1999;10(5):913-22 - PMID: 10232676
Shayakul C, Breton S, Brown D, Alper SL
Gene therapy of inherited renal tubular disease.
Am J Kidney Dis. 1999;34(2):374-9 - PMID: 10430991 - DOI: 10.1016/s0272-6386(99)70372-0
Jensen LJ, Schmitt BM, Berger UV, Nsumu NN, Boron WF, Hediger MA, Brown D, Breton S
Localization of sodium bicarbonate cotransporter (NBC) protein and messenger ribonucleic acid in rat epididymis.
Biol Reprod. 1999;60(3):573-9 - PMID: 10026101 - DOI: 10.1095/biolreprod60.3.573
Breton S, Tyszkowski R, Sabolic I, Brown D
Postnatal development of H+ ATPase (proton-pump)-rich cells in rat epididymis.
Histochem Cell Biol. 1999;111(2):97-105 - PMID: 10090570
Breton S, Brown D
Cold-induced microtubule disruption and relocalization of membrane proteins in kidney epithelial cells.
J Am Soc Nephrol. 1998;9(2):155-66 - PMID: 9527391
Zuk A, Bonventre JV, Brown D, Matlin KS
Polarity, integrin, and extracellular matrix dynamics in the postischemic rat kidney.
Am J Physiol Cell Physiol. 1998;275(3):C711-C731 - PMID: 29585718 - DOI: 10.1152/ajpcell.1998.275.3.C711
Breton S, Hammar K, Smith PJS, Brown D
Proton secretion in the male reproductive tract: involvement of Cl--independent HCO 3 - transport.
Am J Physiol Cell Physiol. 1998;275(4):C1134-C1142 - PMID: 29585324 - DOI: 10.1152/ajpcell.1998.275.4.C1134
Breton S, Hammar K, Smith PJ, Brown D
Proton secretion in the male reproductive tract: involvement of Cl--independent HCO-3 transport.
Am J Physiol. 1998;275(4 Pt 1):C1134-42 - PMID: 9755067 - DOI: 10.1152/ajpcell.1998.275.4.C1134
Breton S, Lisanti MP, Tyszkowski R, McLaughlin M, Brown D
Basolateral distribution of caveolin-1 in the kidney. Absence from H+-atpase-coated endocytic vesicles in intercalated cells.
J Histochem Cytochem. 1998;46(2):205-14 - PMID: 9446827 - DOI: 10.1177/002215549804600209
Brown D, Sabolic I, Breton S
Polarized expression of membrane proteins in renal epithelial cells: involvement of specialized transport vesicles and intracellular pathways.
Adv Nephrol Necker Hosp. 1998;27:297-315 - PMID: 9408453
Alper SL, Stuart-Tilley AK, Biemesderfer D, Shmukler BE, Brown D
Immunolocalization of AE2 anion exchanger in rat kidney.
Am J Physiol Renal Physiol. 1997;273(4):F601-F614 - PMID: 29587100 - DOI: 10.1152/ajprenal.1997.273.4.F601
Shayakul C, Kanai Y, Lee WS, Brown D, Rothstein JD, Hediger MA
Localization of the high-affinity glutamate transporter EAAC1 in rat kidney.
Am J Physiol Renal Physiol. 1997;273(6):F1023-F1029 - PMID: 29586122 - DOI: 10.1152/ajprenal.1997.273.6.F1023
Kawachi H, Kurihara H, Topham PS, Brown D, Shia MA, Orikasa M, Shimizu F, Salant DJ
Slit diaphragm-reactive nephritogenic MAb 5-1-6 alters expression of ZO-1 in rat podocytes.
Am J Physiol Renal Physiol. 1997;273(6):F984-F993 - PMID: 29586119 - DOI: 10.1152/ajprenal.1997.273.6.F984
Brown D, Lee R, Bonventre JV
Redistribution of villin to proximal tubule basolateral membranes after ischemia and reperfusion.
Am J Physiol Renal Physiol. 1997;273(6):F1003-F1012 - PMID: 29586118 - DOI: 10.1152/ajprenal.1997.273.6.F1003
Brown D, Smith PJ, Breton S
Role of V-ATPase-rich cells in acidification of the male reproductive tract.
J Exp Biol. 1997;200(Pt 2):257-62 - PMID: 9050233
Breton S, Smith PJS, Brown D
Presence de cellules acidifiantes dans l'epididyme et le canal deferent: implication de la pompe a protons
Medecine/Sciences. 1997;13:57-61
Breton S, Smith PJ, Lui B, Brown D
Acidification of the male reproductive tract by a proton pumping (H+)-ATPase.
Nature Med. 1996;2(4):470-2 - PMID: 8597961 - DOI: 10.1038/nm0496-470
Brown D, Breton S
Mitochondria-rich, proton-secreting epithelial cells.
J Exp Biol. 1996;199(Pt 11):2345-58 - PMID: 9114500
Breton S, Alper SL, Gluck SL, Sly WS, Barker JE, Brown D
Depletion of intercalated cells from collecting ducts of carbonic anhydrase II-deficient (CAR2 null) mice.
Am J Physiol. 1995;269(6 Pt 2):F761-74 - PMID: 8594870 - DOI: 10.1152/ajprenal.1995.269.6.F761
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