About
Charles Lin's Lab
The main research focus of our group is to develop minimally invasive optical techniques for in vivo imaging and monitoring of cells and tissues as well as therapeutic applications of lasers. The diagnostic techniques will help to answer important biological questions, such as:
- In-vivo monitoring of cell trafficking in circulation
- Imaging of vasculature and microenvironment in tissue
- Interaction of cells with microenvironment
The therapeutic techniques allow us to target cellular and subcellular structures by means of selective absorption of endogenous or exogenous chromophores. Selective targeting may be helpful for treating various pathologies, such as retinal diseases or destruction of tumors, without causing adverse side effects to healthy tissue.
Recent Publications (more...)
In vivo imaging of hematopoietic stem cells and their microenvironment.
J Biophotonics. 2009;2(11):619-631 - PMID: 19847800
Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow.
Nature. 2009;459(7243):103-7 - PMID: 19322176 - PMCID: PMC2761017
CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.
Blood. 2009;113:4341-51 - PMID: 19139079 - PMCID: PMC2676090
Recent News (more...)
2009-11-09: Nature Nanotechnology Feature article describes CSB work on TB detection using magnetic nanoparticles, microfluidics and nuclear magnetic resonance. (pdf)
2009-10-12: Dr. Ralph Weissleder has been elected as a new member of the U.S. National Academies Institute of Medicine (IOM). This is one of the highest honors in the fields of health and medicine.
2009-09-30: Sylvie Breton, PhD was among the first 42 recipients of Transformative R01 Awards, a new program designed to give recipients resources and flexibility to pursue high-risk projects that have the potential to overturn current scientific assumptions.
2009-09-09: F1000 Medicine features the Science article ‘Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites’.
2009-09-03: CSB welcomes John Higgins, MD. His Lab will study the dynamics of human pathophysiologic processes by developing mathematical descriptions of complex human disease phenotypes and how they change over time.