Castro, Cesar, MD

Associate Professor

Director of MGH Gynecology Oncology
Director, Cancer Therapy Program

Phone: 617-726-1941
Email: Castro.Cesar@mgh.harvard.edu
Lab: Castro, Cesar

Cesar M. Castro, MD, MSc is Assistant Professor of Medicine at Harvard Medical School, Director – Cancer Theranostics Program at the MGH Center for Systems Biology, and an Attending Physician at the MGH Cancer Center. He received both Bachelor’s and Master’s degrees from the University of California – Berkeley and a Medical Degree from the University of California – San Francisco (UCSF) where he also completed a categorical residency in Internal Medicine. He trained in Medical Oncology through the combined fellowship between MGH, Dana-Farber Cancer Institute, and Brigham and Women’s Hospital. During that time, Dr. Castro received an additional Master’s degree in Clinical Investigation from Harvard Medical School.

Publications

  • Song J, Cho MH, Cho H, Song Y, Lee SW, Nam HC, Yoon TH, Shin JC, Hong JS, Kim Y, Ekanayake E, Jeon J, You DG, Im SG, Choi GS, Park JS, Carter BC, Balaj L, Seo AN, Miller MA, Park SY, Kang T, Castro CM, Lee H Amplifying mutational profiling of extracellular vesicle mRNA with SCOPE. Nat Biotechnol. 2024;:ePub - PMID: 39375445 - DOI: 10.1038/s41587-024-02426-6

  • Owokuhaisa J, Turyakira E, Ssedyabane F, Tusubira D, Kajabwangu R, Musinguzi P, Galiwango M, Randall TC, Kakongi N, Castro CM, Atukunda EC, Maling S Barriers and facilitators of retention in care after cervical cancer screening: patients' and healthcare providers' perspectives. BMC Womens Health. 2024;24(1):516 - PMID: 39272088 - PMCID: PMC11401415 - DOI: 10.1186/s12905-024-03343-1

  • Lee CY, Kim H, Degani I, Lee H, Sandoval A, Nam Y, Pascavis M, Park HG, Randall T, Ly A, Castro CM, Lee H Empowering the on-site detection of nucleic acids by integrating CRISPR and digital signal processing. Nat Commun. 2024;15(1):6271 - PMID: 39054353 - PMCID: PMC11272939 - DOI: 10.1038/s41467-024-50588-3

  • Arai MS, Kim H, Pascavis M, Cha B, Brambilla G, Cho YK, Park J, Vilela RRC, de Camargo ASS, Castro CM, Lee H Upconverting Nanoparticle-based Enhanced Luminescence Lateral-Flow Assay for Urinary Biomarker Monitoring. ACS Appl Mater Interfaces. 2024;16(29):38243-38251 - PMID: 38980927 - DOI: 10.1021/acsami.4c06117

  • Ssedyabane F, Obuku EA, Namisango E, Ngonzi J, Castro CM, Lee H, Randall TC, Ocan M, Apunyo R, Annet Kinengyere A, Kajabwangu R, Tahirah Kisawe A, Nambi Najjuma J, Tusubira D, Niyonzima N The diagnostic accuracy of serum and plasma microRNAs in detection of cervical intraepithelial neoplasia and cervical cancer: A systematic review and meta-analysis. Gynecol Oncol Rep. 2024;54:101424 - PMID: 38939506 - PMCID: PMC11208915 - DOI: 10.1016/j.gore.2024.101424

  • Ssedyabane F, Niyonzima N, Nambi Najjuma J, Birungi A, Atwine R, Tusubira D, Randall TC, Castro CM, Lee H, Ngonzi J Prevalence of cervical intraepithelial lesions and associated factors among women attending a cervical cancer clinic in Western Uganda; results based on Pap smear cytology. SAGE Open Med. 2024;12:20503121241252265 - PMID: 38764539 - PMCID: PMC11100407 - DOI: 10.1177/20503121241252265

  • Richardson DL, Moore KN, Vergote I, Gilbert L, Martin LP, Mantia-Smaldone GM, Castro CM, Provencher D, Matulonis UA, Stec J, Wang Y, Method M, O'Malley DM Phase 1b study of mirvetuximab soravtansine, a folate receptor alpha (FRα)-targeting antibody-drug conjugate, in combination with carboplatin and bevacizumab in patients with platinum-sensitive ovarian cancer. Gynecol Oncol. 2024;185:186-193 - PMID: 38447347 - DOI: 10.1016/j.ygyno.2024.01.045

  • Batool SM, Hsia T, Beecroft A, Lewis B, Ekanayake E, Rosenfeld Y, Escobedo AK, Gamblin AS, Rawal S, Cote RJ, Watson M, Wong DTW, Patel AA, Skog J, Papadopoulos N, Bettegowda C, Castro CM, Lee H, Srivastava S, Carter BS, Balaj L Extrinsic and intrinsic preanalytical variables affecting liquid biopsy in cancer. Cell Rep Med. 2023;4(10):101196 - PMID: 37725979 - PMCID: PMC10591035 - DOI: 10.1016/j.xcrm.2023.101196

  • Batool SM, Yekula A, Khanna P, Hsia T, Gamblin AS, Ekanayake E, Escobedo AK, You DG, Castro CM, Im H, Kilic T, Garlin MA, Skog J, Dinulescu DM, Dudley J, Agrawal N, Cheng J, Abtin F, Aberle DR, Chia D, Elashoff D, Grognan T, Krysan K, Oh SS, Strom C, Tu M, Wei F, Xian RR, Skates SJ, Zhang DY, Trinh T, Watson M, Aft R, Rawal S, Agarwal A, Kesmodel SB, Yang C, Shen C, Hochberg FH, Wong DTW, Patel AA, Papadopoulos N, Bettegowda C, Cote RJ, Srivastava S, Lee H, Carter BS, Balaj L The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring. Cell Rep Med. 2023;4(10):101198 - PMID: 37716353 - PMCID: PMC10591039 - DOI: 10.1016/j.xcrm.2023.101198

  • Jo A, Green A, Medina JE, Iyer S, Ohman AW, McCarthy ET, Reinhardt F, Gerton T, Demehin D, Mishra R, Kolin DL, Zheng H, Cheon J, Crum CP, Weinberg RA, Rueda BR, Castro CM, Dinulescu DM, Lee H Inaugurating High-Throughput Profiling of Extracellular Vesicles for Earlier Ovarian Cancer Detection. Adv Sci (Weinh). 2023;10(27):e2301930 - PMID: 37485618 - PMCID: PMC10520636 - DOI: 10.1002/advs.202301930

  • Hong JS, Son T, Castro CM, Im H CRISPR/Cas13a-Based MicroRNA Detection in Tumor-Derived Extracellular Vesicles. Adv Sci (Weinh). 2023;10(24):e2301766 - PMID: 37340600 - PMCID: PMC10460892 - DOI: 10.1002/advs.202301766

  • Silberman JN, Bercow AS, Gockley AA, Eisenhauer EL, Sisodia R, Randall T, Del Carmen MG, Goodman A, Castro CM, Melamed A, Bregar AJ Trends in the use of neoadjuvant chemotherapy for low-grade serous ovarian cancer in the United States. Gynecol Oncol. 2023;175:60-65 - PMID: 37327540 - DOI: 10.1016/j.ygyno.2023.06.001

  • Kwak TJ, Son T, Hong JS, Winter UA, Jeong MH, McLean C, Weissleder R, Lee H, Castro CM, Im H Electrokinetically enhanced label-free plasmonic sensing for rapid detection of tumor-derived extracellular vesicles. Biosens Bioelectron. 2023;237:115422 - PMID: 37301179 - PMCID: PMC10527155 - DOI: 10.1016/j.bios.2023.115422

  • Gupta S, Hanna PE, Ouyang T, Yamada KS, Sawtell R, Wang Q, Katz-Agranov N, Feghali L, Krasner CN, Bouberhan S, Castro CM, Sise ME Kidney Function in Patients with Ovarian Cancer Treated with Poly (ADP-ribose) polymerase (PARP) Inhibitors. J Natl Cancer Inst. 2023;115(7):831-837 - PMID: 37074956 - PMCID: PMC10323894 - DOI: 10.1093/jnci/djad070

  • Chin LK, Yang JY, Chousterman B, Jung S, Kim DG, Kim DH, Lee S, Castro CM, Weissleder R, Park SG, Im H Dual-Enhanced Plasmonic Biosensing for Point-of-Care Sepsis Detection. ACS Nano. 2023;17(4):3610-3619 - PMID: 36745820 - PMCID: PMC10150330 - DOI: 10.1021/acsnano.2c10371

  • Gilbert L, Oaknin A, Matulonis UA, Mantia-Smaldone GM, Lim PC, Castro CM, Provencher D, Memarzadeh S, Method M, Wang J, Moore KN, O'Malley DM Safety and efficacy of mirvetuximab soravtansine, a folate receptor alpha (FRα))-targeting antibody-drug conjugate (ADC), in combination with bevacizumab in patients with platinum-resistant ovarian cancer. Gynecol Oncol. 2023;170:241-247 - PMID: 36736157 - DOI: 10.1016/j.ygyno.2023.01.020

  • Roh YH, Lee CY, Lee S, Kim H, Ly A, Castro CM, Cheon J, Lee JH, Lee H CRISPR-Enhanced Hydrogel Microparticles for Multiplexed Detection of Nucleic Acids. Adv Sci (Weinh). 2023;10(10):e2206872 - PMID: 36725305 - PMCID: PMC10074104 - DOI: 10.1002/advs.202206872

  • Jo A, Green A, Medina JE, Iyer S, Ohman AW, McCarthy ET, Reinhardt F, Gerton T, Demehin D, Mishra R, Kolin DL, Zheng H, Crum CP, Weinberg RA, Rueda BR, Castro CM, Dinulescu DM, Lee H Profiling extracellular vesicles in circulation enables the early detection of ovarian cancer. bioRxiv. 2023;:ePub - PMID: 36711872 - PMCID: PMC9882285 - DOI: 10.1101/2023.01.19.524549

  • Jeong MH, Son T, Tae YK, Park CH, Lee HS, Chung MJ, Park JY, Castro CM, Weissleder R, Jo JH, Bang S, Im H Plasmon-Enhanced Single Extracellular Vesicle Analysis for Cholangiocarcinoma Diagnosis. Adv Sci (Weinh). 2023;10(8):e2205148 - PMID: 36698298 - PMCID: PMC10015870 - DOI: 10.1002/advs.202205148

  • Chin LK, Li H, Choi JH, Iwamoto Y, Oh J, Min J, Beak SK, Yoo D, Castro CM, Lee D, Im H Hydrogel Stamping for Rapid, Multiplexed, Point-of-Care Immunostaining of Cells and Tissues. ACS Appl Mater Interfaces. 2022;14(24):27613-27622 - PMID: 35671240 - DOI: 10.1021/acsami.2c05071

  • Woo HK, Cho YK, Lee CY, Lee H, Castro CM, Lee H Characterization and modulation of surface charges to enhance extracellular vesicle isolation in plasma. Theranostics. 2022;12(5):1988-1998 - PMID: 35265194 - PMCID: PMC8899565 - DOI: 10.7150/thno.69094 - Cover

  • Min J, Allen M, Castro CM, Lee H, Weissleder R, Im H Computational Optics for Point-of-Care Breast Cancer Profiling. Methods Mol Biol. 2022;2393:153-162 - PMID: 34837178 - PMCID: PMC9283060 - DOI: 10.1007/978-1-0716-1803-5_8

  • Yu H, Lee H, Cheong J, Woo SW, Oh J, Oh HK, Lee JH, Zheng H, Castro CM, Yoo YE, Kim MG, Cheon J, Weissleder R, Lee H A rapid assay provides on-site quantification of tetrahydrocannabinol in oral fluid. Sci Transl Med. 2021;13(616):eabe2352 - PMID: 34669441 - PMCID: PMC9126021 - DOI: 10.1126/scitranslmed.abe2352 - Cover

  • Park J, Park JS, Huang CH, Jo A, Cook K, Wang R, Lin HY, Van Deun J, Li H, Min J, Wang L, Yoon G, Carter BS, Balaj L, Choi GS, Castro CM, Weissleder R, Lee H An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma. Nat Biomed Eng. 2021;5(7):678-689 - PMID: 34183802 - PMCID: PMC8437135 - DOI: 10.1038/s41551-021-00752-7

  • Yang Z*, Francisco J*, Reese AS, Spriggs DR, Im H, Castro CM Addressing cervical cancer screening disparities through advances in artificial intelligence and nanotechnologies for cellular profiling. Biophys Rev. 2021;2:011303 - PMID: 33842926 - PMCID: PMC8015256 - DOI: 10.1063/5.0043089

  • Chin LK*, Son T*, Hong JS, Liu AQ, Skog J, Castro CM, Weissleder R, Lee H*, Im H* Plasmonic Sensors for Extracellular Vesicle Analysis: From Scientific Development to Translational Research. ACS Nano. 2020;14(11):14528-14548 - PMID: 33119256 - PMCID: PMC8423498 - DOI: 10.1021/acsnano.0c07581

  • Yang KS, Lin HY, Curley C, Welch MW, Wolpin BM, Lee H, Weissleder R, Im H*, Castro CM* Bead-Based Extracellular Vesicle Analysis Using Flow Cytometry. Adv Biosyst. 2020;4(12):e2000203 - PMID: 33103361 - PMCID: PMC7718389 - DOI: 10.1002/adbi.202000203

  • Min J*, Chin LK*, Oh J, Landeros C, Vinegoni C, Lee J, Lee SJ, Park JY, Liu AQ, Castro CM, Lee H, Im H, Weissleder R CytoPAN—Portable cellular analyses for rapid point-of-care cancer diagnosis. Sci Transl Med. 2020;12:eaaz9746 - PMID: 32759277 - PMCID: PMC8217912 - DOI: 10.1126/scitranslmed.aaz9746

  • O'Malley DM, Matulonis UA, Birrer MJ, Castro CM, Gilbert L, Vergote I, Martin LP, Mantia-Smaldone GM, Martin AG, Bratos R, Penson RT, Malek K, Moore KN Phase Ib study of mirvetuximab soravtansine, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC), in combination with bevacizumab in patients with platinum-resistant ovarian cancer. Gynecol Oncol. 2020;157(2):379-385 - PMID: 32081463 - DOI: 10.1016/j.ygyno.2020.01.037

  • Liu JF, Herold C, Gray KP, Penson RT, Horowitz N, Konstantinopoulos PA, Castro CM, Hill SJ, Curtis J, Luo W, Matulonis UA, Cannistra SA, Dizon DS Assessment of Combined Nivolumab and Bevacizumab in Relapsed Ovarian Cancer: A Phase 2 Clinical Trial. JAMA Oncol. 2019;5(12):1731-1738 - PMID: 31600397 - PMCID: PMC6802049 - DOI: 10.1001/jamaoncol.2019.3343

  • Pathania D, Landeros C, Rohrer L, D’Agostino V, Hong S, Degani I, Avila-Wallace M, Pivovarov M, Randall T, Weissleder R, Lee H, Im H, Castro CM Point-of-care cervical cancer screening using deep learning-based microholography. Theranostics. 2019;9(26):8438-8447 - PMID: 31879529 - PMCID: PMC6924258 - DOI: 10.7150/thno.37187

  • Huang CH, Park YI, Lin HY, Pathania D, Park KS, Avila-Wallace M, Castro CM, Weissleder R, Lee H Compact and Filter-Free Luminescence Biosensor for Mobile In-Vitro Diagnoses. ACS Nano. 2019;13(10):11698-11706 - PMID: 31461265 - PMCID: PMC7307311 - DOI: 10.1021/acsnano.9b05634

  • Lee H, Castro CM Thermophoretically enriched detection. Nat Biomed Eng. 2019;3(3):163-164 - PMID: 30948812 - DOI: 10.1038/s41551-019-0364-9

  • Krasner CN, Castro C, Penson RT, Roche M, Matulonis UA, Morgan MA, Drescher C, Armstrong DK, Wolfe JK, Lee H, Supko JG, Seiden M, Birrer MJ, Dizon DS Final report on serial phase II trials of all-intraperitoneal chemotherapy with or without bevacizumab for women with newly diagnosed, optimally cytoreduced carcinoma of Müllerian origin. Gynecol Oncol. 2019;153(2):223-229 - PMID: 30765148 - DOI: 10.1016/j.ygyno.2019.02.004

  • Kim SJ*, Wang C*, Zhao B, Im H, Min J, Choi HJ, Tadros J, Choi NR, Castro CM, Weissleder R, Lee H, Lee K Deep transfer learning-based hologram classification for molecular diagnostics. Sci Rep. 2018;8(1):17003 - PMID: 30451953 - PMCID: PMC6242900 - DOI: 10.1038/s41598-018-35274-x

  • Huber S, Min C, Staat C, Oh J, Castro CM, Haase A, Weissleder R, Gleich B, Lee H Multichannel digital heteronuclear magnetic resonance biosensor. Biosens Bioelectron. 2018;126:240-248 - PMID: 30445298 - PMCID: PMC6483068 - DOI: 10.1016/j.bios.2018.10.052

  • Min J, Im H, Allen M, McFarland PJ, Degani I, Yu H, Normandin E, Pathania D, Patel J, Castro CM, Weissleder R, Lee H Computational Optics Enables Breast Cancer Profiling in Point-Of-Care Settings. ACS Nano. 2018;12(9):9081-9090 - PMID: 30113824 - PMCID: PMC6519708 - DOI: 10.1021/acsnano.8b03029

  • Im H, Pathania D, McFarland PJ, Sohani AR, Degani I, Allen M, Coble M, Kilcoyne A, Hong S, Rohrer L, Abramson JS, Dryden-Peterson S, Fexon L, Pivovarov M, Chabner B, Lee H, Castro CM, Weissleder R Design and clinical validation of a point-of-care device for the diagnosis of lymphoma via contrast- enhanced microholography and machine learning. Nat Biomed Eng. 2018;2(9):666-674 - PMID: 30555750 - PMCID: PMC6291220 - DOI: 10.1038/s41551-018-0265-3

  • Min J, Nothing M, Coble B, Zheng H, Park J, Im H, Weber GF, Castro CM, Swirski FK, Weissleder R, Lee H Integrated Biosensor for Rapid and Point-Of-Care Sepsis Diagnosis. ACS Nano. 2018;12(4):3378-3384 - PMID: 29533646 - PMCID: PMC6019292 - DOI: 10.1021/acsnano.7b08965

  • Lin HY, Yang KS, Curley C, Lee H, Welch MW, Wolpin BM, Weissleder R, Im H, Castro C Bead Enhancement of EV Analysis. bioRxiv. 2018;:ePub - DOI: 10.1101/269423

  • Shao H, Im H, Castro CM, Breakefield X, Weissleder R, Lee H New Technologies for Analysis of Extracellular Vesicles. Chem Rev. 2018;118(4):1917-1950 - PMID: 29384376 - PMCID: PMC6029891 - DOI: 10.1021/acs.chemrev.7b00534

  • Kim SJ, Zhao B, Im H, Min J, Choi N, Castro CM, Weissleder R, Lee H, Lee K Deep-learning based hologram classification for molecular diagnostics. bioRxiv. 2017;192559:ePub - DOI: 10.1101/192559

  • Park J*, Im H*, Hong S, Castro CM, Weissleder R, Hakho Lee H Analyses of Intravesicular Exosomal Proteins Using a Nano-Plasmonic System. ACS Photonics. 2017;5(2):487-494 - PMID: 29805987 - PMCID: PMC5966285 - DOI: 10.1021/acsphotonics.7b00992

  • Min C, Park J, Mun JK, Lim Y, Min J, Lim JW, Kang DM, Ahn HK, Shin TH, Cheon J, Lee HS, Weissleder R, Castro CM, Lee H Integrated microHall magnetometer to measure the magnetic properties of nanoparticles. Lab Chip. 2017;17(23):4000-4007 - PMID: 29067383 - PMCID: PMC5698130 - DOI: 10.1039/c7lc00934h

  • Park J, Lin HY, Assaker JP, Jeong S, Huang CH, Kurdi A, Lee K, Fraser K, Min C, Eskandari S, Routray S, Tannous BA, Abdi R, Riella L, Chandraker A, Castro CM, Weissleder R, Lee H, Azzi JR Integrated Kidney Exosome Analysis (iKEA) For The Detection Of Kidney Transplant Rejection. ACS Nano. 2017;11(11):11041-11046 - PMID: 29053921 - PMCID: PMC6237084 - DOI: 10.1021/acsnano.7b05083

  • Oza AM, Tinker AV, Oaknin A, Shapira-Frommer R, McNeish IA, Swisher EM, Ray-Coquard I, Bell-McGuinn K, Coleman RL, O'Malley DM, Leary A, Chen LM, Provencher D, Ma L, Brenton JD, Konecny GE, Castro CM, Giordano H, Maloney L, Goble S, Lin KK, Sun J, Raponi M, Rolfe L, Kristeleit RS Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high-grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: Integrated analysis of data from Study 10 and ARIEL2. Gynecol Oncol. 2017;147(2):267-275 - PMID: 28882436 - DOI: 10.1016/j.ygyno.2017.08.022

  • Im H, Yang K, Lee H, Castro CM Characterization of Extracellular Vesicles by Surface Plasmon Resonance. Methods Mol Biol. 2017;1660:133-141 - PMID: 28828653 - DOI: 10.1007/978-1-4939-7253-1_11

  • Lin HY, Huang CH, Park J, Pathania D, Castro CM, Fasano A, Weissleder R, Lee H Integrated Magneto-Chemical Sensor For On-Site Food Allergen Detection. ACS Nano. 2017;11(10):10062-10069 - PMID: 28792732 - DOI: 10.1021/acsnano.7b04318

  • Im H, Lee K, Weissleder R, Lee H, Castro CM Novel nanosensing technologies for exosome detection and profiling. Lab Chip. 2017;17(17):2892-2898 - PMID: 28745363 - PMCID: PMC5572557 - DOI: 10.1039/c7lc00247e

  • Yang KS*, Im H*, Hong S, Pergolini I, Del Castillo AF, Wang R, Clardy S, Huang CH, Pille C, Ferrone S, Yang R, Castro CM, Lee H, Del Castillo CF, Weissleder R Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy. Sci Transl Med. 2017;9(391):eaal3226 - PMID: 28539469 - PMCID: PMC5846089 - DOI: 10.1126/scitranslmed.aal3226

  • Hong S, Park KS, Weissleder R, Castro CM, Lee H Facile silicification of plastic surface for bioassays. Chem Commun. 2017;53(13):2134-2137 - PMID: 28134385 - PMCID: PMC5327824 - DOI: 10.1039/c6cc09359k

  • Castro CM Good to the last "emulsified" drop. Sci Transl Med. 2017;9(373):ePub - PMID: 28100835 - DOI: 10.1126/scitranslmed.aal4993

  • Park YI, Kim E, Huang CH, Park KS, Castro CM, Lee H, Weissleder R Facile Coating Strategy to Functionalize Inorganic Nanoparticles for Biosensing. Bioconjug Chem. 2017;28(1):33-37 - PMID: 27792877 - PMCID: PMC5474933 - DOI: 10.1021/acs.bioconjchem.6b00524

  • Im H, Lee H, Castro CM Challenges influencing next generation technologies for precision medicine. Expert Rev Precis Med Drug Dev. 2016;1(2):121-123 - PMID: 28008420 - PMCID: PMC5166706 - DOI: 10.1080/23808993.2016.1165073

  • Castro CM Taking cancer drug screening very personally. Sci Transl Med. 2016;8(367):367ec190 - PMID: 27903858 - DOI: 10.1126/scitranslmed.aal2799

  • Pathania D*, Im H*, Kilcoyne A, Sohani AR, Fexon L, Pivovarov M, Abramson JS, Randall TC, Chabner BA, Weissleder R, Lee H, Castro CM Holographic Assessment of Lymphoma Tissue (HALT) for Global Oncology Field Applications. Theranostics. 2016;6(10):1603-10 - PMID: 27446494 - PMCID: PMC4955059 - DOI: 10.7150/thno.15534

  • Sosulski A, Horn H, Zhang L, Coletti C, Vathipadiekal V, Castro CM, Birrer MJ, Nagano O, Saya H, Lage K, Donahoe PK, Pépin D CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis. PLoS ONE. 2016;11(6):e0156595 - PMID: 27253518 - PMCID: PMC4890777 - DOI: 10.1371/journal.pone.0156595

  • Park KS*, Huang CH*, Lee K, Yoo YE, Castro CM, Weissleder R, Lee H Rapid identification of health care–associated infections with an integrated fluorescence anisotropy system. Sci Adv. 2016;2(5):e1600300 - PMID: 28861468 - PMCID: PMC5565941 - DOI: 10.1126/sciadv.1600300

  • Im H, Park YI, Pathania D, Castro CM, Weissleder R, Lee H Digital diffraction detection of protein markers for avian influenza. Lab Chip. 2016;16(8):1340-5 - PMID: 26980325 - PMCID: PMC4829473 - DOI: 10.1039/c5lc01558h

  • Jeong S, Park J, Pathania D, Castro CM, Weissleder R, Lee H Integrated Magneto-Electrochemical Sensor for Exosome Analysis. ACS Nano. 2016;10(2):1802-1809 - PMID: 26808216 - PMCID: PMC4802494 - DOI: 10.1021/acsnano.5b07584

  • Pépin D, Sosulski A, Zhang L, Wang D, Vathipadiekal V, Hendren K, Coletti CM, Yu A, Castro CM, Birrer MJ, Gao G, Donahoe PK AAV9 delivering a modified human Mullerian inhibiting substance as a gene therapy in patient-derived xenografts of ovarian cancer. Proc Natl Acad Sci U S A. 2015;112(32):E4418-27 - PMID: 26216943 - PMCID: PMC4538667 - DOI: 10.1073/pnas.1510604112

  • Turetsky A, Lee K, Song J, Giedt RJ, Kim E, Kovach AE, Hochberg EP, Castro CM, Lee H, Weissleder R On chip analysis of CNS lymphoma in cerebrospinal fluid. Theranostics. 2015;5(8):796-804 - PMID: 26000053 - PMCID: PMC4440438 - DOI: 10.7150/thno.11220

  • Im H, Shao H, Weissleder R, Castro CM, Lee H Nano-plasmonic exosome diagnostics. Expert Rev Mol Diagn. 2015;15(6):725-33 - PMID: 25936957 - PMCID: PMC4675626 - DOI: 10.1586/14737159.2015.1041378

  • Im H, Castro CM, Shao H, Liong M, Song J, Pathania D, Fexon L, Min C, Avila-Wallace M, Zurkiya O, Rho J, Magaoay B, Tambouret RH, Pivovarov M, Weissleder R*, Lee H* Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone. Proc Natl Acad Sci U S A. 2015;112(18):5613-8 - PMID: 25870273 - PMCID: PMC4426451 - DOI: 10.1073/pnas.1501815112

  • Castro CM, Im H, Le C, Lee H, Weissleder R, Birrer MJ Exploring alternative ovarian cancer biomarkers using innovative nanotechnology strategies. Cancer Metastasis Rev. 2015;34(1):75-82 - PMID: 25543192 - PMCID: PMC5474936 - DOI: 10.1007/s10555-014-9546-9

  • Im H*, Shao H*, Park YI, Peterson VM, Castro CM, Weissleder R*, Lee H* Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor. Nat Biotechnol. 2014;32(5):490-5 - PMID: 24752081 - PMCID: PMC4356947 - DOI: 10.1038/nbt.2886

  • Ullal AV*, Peterson V*, Agasti SS, Tuang S, Juric D, Castro CM, Weissleder R Cancer Cell Profiling by Barcoding Allows Multiplexed Protein Analysis in Fine-Needle Aspirates. Sci Transl Med. 2014;6(219):219ra9 - PMID: 24431113 - PMCID: PMC4063286 - DOI: 10.1126/scitranslmed.3007361

  • Rho J, Chung J, Im H, Liong M, Shao H, Castro CM, Weissleder R, Lee H Magnetic Nanosensor for Detection and Profiling of Erythrocyte-Derived Microvesicles. ACS Nano. 2013;7(12):11227-33 - PMID: 24295203 - PMCID: PMC3898036 - DOI: 10.1021/nn405016y

  • Peterson VM*, Castro CM*, Chung J, Miller NC, Ullal AV, Castano MD, Penson RT, Lee H, Birrer MJ, Weissleder R Ascites analysis by a microfluidic chip allows tumor-cell profiling. Proc Natl Acad Sci U S A. 2013;110(51):E4978-86 - PMID: 24297935 - PMCID: PMC3870756 - DOI: 10.1073/pnas.1315370110

  • Ghazani A, Pectasides M, Sharma A, Castro CM, Mino-Kenudson M, Lee H, Shepard JA, Weissleder R Molecular characterization of scant lung tumor cells using iron-oxide nanoparticles and micro-nuclear magnetic resonance. Nanomedicine. 2013;10 :661-668 - PMID: 24200523 - PMCID: PMC3966960 - DOI: 10.1016/j.nano.2013.10.008

  • Castro CM, Ghazani AA, Chung J, Shao H, Issadore D, Yoon TJ, Weissleder R, Lee H Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells. Lab Chip. 2013;14(1):14-23 - PMID: 23835814 - PMCID: PMC3844052 - DOI: 10.1039/c3lc50621e

  • Keliher EJ, Reiner T, Earley S, Klubnick J, Tassa C, Lee AJ, Ramaswamy S, Bardeesy N, Hanahan D, Depinho RA, Castro CM, Weissleder R Targeting cathepsin e in pancreatic cancer by a small molecule allows in vivo detection. Neoplasia. 2013;15(7):684-93 - PMID: 23814481 - PMCID: PMC3689232 - DOI: 10.1593/neo.13276

  • Chung HJ, Castro CM, Im H, Lee H*, Weissleder R* A magneto-DNA nanoparticle system for rapid detection and phenotyping of bacteria. Nat Nanotechnol. 2013;8(5):369-75 - PMID: 23644570 - PMCID: PMC3711657 - DOI: 10.1038/nnano.2013.70

  • Ghazani AA, McDermott S, Pectasides M, Sebas M, Mino-Kenudson M, Lee H, Weissleder R, Castro CM Comparison of select cancer biomarkers in human circulating and bulk tumor cells using magnetic nanoparticles and miniaturized micro-NMR system. Nanomedicine (Lond). 2013;9(7):1009-17 - PMID: 23570873 - PMCID: PMC4330975 - DOI: 10.1016/j.nano.2013.03.011

  • Issadore D, Chung J*, Shao H*, Liong M, Ghazani AA, Castro CM, Weissleder R*, Lee H* Ultrasensitive Clinical Enumeration of Rare Cells ex Vivo Using a Micro-Hall Detector. Sci Transl Med. 2012;4 (141):141ra92 - PMID: 22764208 - PMCID: PMC3603277 - DOI: 10.1126/scitranslmed.3003747

  • Ghazani AA, Castro CM, Gorbatov R, Lee H, Weissleder R Sensitive and Direct Detection of Circulating Tumor Cells by Multimarker µ-Nuclear Magnetic Resonance. Neoplasia. 2012;14(5):388-95 - PMID: 22745585 - PMCID: PMC3384426 - DOI: 10.1596/neo.12696

  • Peterson VM, Castro CM, Lee H, Weissleder R Orthogonal Amplification of Nanoparticles for Improved Diagnostic Sensing. ACS Nano. 2012;6(4):3506-13 - PMID: 22424443 - PMCID: PMC3337350 - DOI: 10.1021/nn300536y

  • Weissleder R, Castro C Interview: Nanomedicine in oncology: miniaturized means to an enormous end. Nanomedicine (Lond). 2011;6(9):1495-8 - PMID: 22077461 - DOI: 10.2217/nnm.11.138

  • Haun JB*, Castro CM*, Wang R, Peterson VM, Marinelli BS, Lee H, Weissleder R. Micro-NMR for Rapid Molecular Analysis of Human Tumor Samples . Sci Transl Med. 2011;3(71):71ra16 - PMID: 21346169 - PMCID: PMC3086073 - DOI: 10.1126/scitranslmed.3002048