Research Focus

Imagine, if we understood what the 30 trillions of cells in our body do at any given moment...

Now compare these 30 trillions of cells (not counting the microbiome!) to the earth population of 8B people (3,750 times more!). This creates a massive undertaking...

At CSB we develop innovative technologies to enable the discovery of new biology, drug targets and diagnostics.

Approach: we develop new integrated systems for subcellular analysis and use innovative imaging tools to decipher dynamic networks. This allows us to interrogate networks at multiple scales from populations to molecules.
CSB work discovers exercise benefits on bone marrow

Modern life comes with many dangers. This includes sedentary behavior, as we all spend increasing time sitting: on the office chair, in the car, and on the sofa. This is risky and leads to obesity, myocardial infarction and stroke. A manuscript published in Nature Medicine describes a new pathway how sedentary behavior causes cardiovascular disease. Mice with access to treadmills had lower blood st Learn more...

Discovering Myeloid Cells In Lung Tumors

Myeloid cells can promote or limit tumor outgrowth but remain poorly understood. In a study published in Immunity, the Pittet lab at the MGH Center for Systems Biology and the Klein lab at Harvard Medical School teamed up to map myeloid cells at the single cell level in human and mouse lung cancer. They made the following findings: 1) Consistent complexity: the same tumor myeloid populations are re Learn more...

Study helps solve mystery of how sleep protects against heart disease

Researchers say they are closer to solving the mystery of how a good night’s sleep protects against heart disease. In studies using mice, they discovered a previously unknown mechanism between the brain, bone marrow, and blood vessels that appears to protect against the development of atherosclerosis, or hardening of the arteries—but only when sleep is healthy and sound. The discovery of this pathw Learn more...

Recent Publications