Aguirre, Aaron, MD, PhD

Assistant Professor

Phone: 617-643-6177
Email: Aguirre.Aaron@mgh.harvard.edu
Lab: Aguirre, Aaron

I am a physician-scientist and an attending cardiologist at the Massachusetts General Hospital and an Assistant Professor of Medicine at Harvard Medical School. I received my M.D. from Harvard Medical School and my Ph.D. in electrical and biomedical engineering from the Massachusetts Institute of Technology, where I worked with Prof. James Fujimoto on high resolution optical coherence tomography methods. I then did residency and fellowship training at the Brigham and Women’s Hospital before completing a postdoctoral research fellowship in cardiovascular imaging at the MGH Center for Systems Biology with Prof. Ralph Weissleder. My laboratory at MGH is now part of the Wellman Center for Photomedicine and the Center for Systems Biology and is closely affiliated with the MGH Cardiovascular Research Center. As a critical care cardiologist in the MGH Heart Center Intensive Care Unit, my clinical practice involves care of medical and surgical patients with all forms of advanced heart disease. I have particular interest in the area of acute decompensated heart failure and the use of mechanical circulatory support devices.

Publications

  • Calcagno DM, Ng RP, Toomu A, Zhang C, Huang K, Aguirre AD, Weissleder R, Daniels LB, Fu Z, King KR Type I interferon responses to ischemic injury begin in the bone marrow of mice and humans and depend on Tet2, Nrf2, and Irf3. bioRxiv. 2020;:ePub - DOI: https://doi.org/10.1101/765404

  • Wang C, Keliher E, Zeller MWG, Wojtkiewicz GR, Aguirre AD, Buckbinder L, Kim HY, Chen J, Maresca K, Ahmed MS, Motlagh NJ, Nahrendorf M, Chen JW An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo. Proc Natl Acad Sci U S A. 2019;116(24):11966-11971 - PMID: 31123149 - PMCID: PMC6575581 - DOI: 10.1073/pnas.1818434116

  • Ahmed MS, Rodell CB, Hulsmans M, Kohler RH, Aguirre A, Nahrendorf M, Weissleder R A Supramolecular Nanocarrier for Delivery of Amiodarone Anti-Arrhythmic Therapy to the Heart. Bioconjug Chem. 2019;30(3):733-740 - PMID: 30615425 - PMCID: PMC6483069 - DOI: 10.1021/acs.bioconjchem.8b00882

  • Hulsmans M, Aguirre AD, Bonner M, Bapat A, Cremer S, Iwamoto Y, King KR, Swirski FK, Milan DJ, Weissleder R, Nahrendorf M Miniaturized, Programmable Pacemaker for Long-Term Studies in the Mouse. Circ Res. 2018;123(11):1208-1219 - PMID: 30571465 - PMCID: PMC6309285 - DOI: 10.1161/CIRCRESAHA.118.313429

  • King KR, Aguirre AD, Ye YX, Sun Y, Roh JD, Ng Jr RP, Kohler RH, Arlauckas SP, Iwamoto Y, Savol A, Sadreyev RI, Kelly M, Fitzgibbons TP, Fitzgerald KA, Mitchison T, Libby P, Nahrendorf M, Weissleder R IRF3 and type I interferons fuel a fatal response to myocardial infarction. Nature Med. 2017;23(12):1481-1487 - PMID: 29106401 - PMCID: PMC6477926 - DOI: 10.1038/nm.4428

  • Minami Y, Wang Z, Aguirre AD, Ong DS, Kim CJ, Uemura S, Soeda T, Lee H, Fujimoto J, Jang IK Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study. J Am Heart Assoc. 2017;6(11):e006241 - PMID: 29092845 - PMCID: PMC5721742 - DOI: 10.1161/JAHA.117.006241

  • Yamamoto E, Xing L, Higuma T, Minami Y, Bryniarski K, Zanchin T, Wang Z, Aguirre AD, Lee H, Jang IK Dynamic neointimal pattern after drug-eluting stent implantation defined by optical coherence tomography. Coron Artery Dis. 2017;28(7):557-563 - PMID: 28704243 - DOI: 10.1097/MCA.0000000000000534

  • Xing L, Higuma T, Wang Z, Aguirre AD, Mizuno K, Takano M, Dauerman HL, Park SJ, Jang Y, Kim CJ, Kim SJ, Choi SY, Itoh T, Uemura S, Lowe H, Walters DL, Barlis P, Lee S, Lerman A, Toma C, Tan JWC, Yamamoto E, Bryniarski K, Dai J, Zanchin T, Zhang S, Yu B, Lee H, Fujimoto J, Fuster V, Jang IK Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography: A 4-Year Follow-Up Study. J Am Coll Cardiol. 2017;69(20):2502-2513 - PMID: 28521888 - DOI: 10.1016/j.jacc.2017.03.556

  • Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M Macrophages Facilitate Electrical Conduction in the Heart. Cell. 2017;169:510-522 - PMID: 28431249 - PMCID: PMC5474950 - DOI: 10.1016/j.cell.2017.03.050

  • Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, Kim HY, Wang C, Chen JW, Swirski FK, Wey HY, Hooker J, Fayad ZA, Mulder WJ, Weissleder R, Nahrendorf M Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease. Nat Commun. 2017;8:14064 - PMID: 28091604 - PMCID: PMC5241815 - DOI: 10.1038/ncomms14064

  • Vergallo R, Uemura S, Soeda T, Minami Y, Cho JM, Ong DS, Aguirre AD, Gao L, Biasucci LM, Crea F, Yu B, Lee H, Kim CJ, Jang IK Prevalence and Predictors of Multiple Coronary Plaque Ruptures: In Vivo 3-Vessel Optical Coherence Tomography Imaging Study. Arterioscler Thromb Vasc Biol. 2016;36(11):2229-2238 - PMID: 27634834 - DOI: 10.1161/ATVBAHA.116.307891

  • Wang Z, Cho YS, Soeda T, Minami Y, Xing L, Jia H, Aguirre A, Vergallo R, Lee H, Fujimoto JG, Yu B, Jang IK Three-dimensional morphological response of lipid-rich coronary plaques to statin therapy: a serial optical coherence tomography study. Coron Artery Dis. 2016;27(5):350-6 - PMID: 27105047 - PMCID: PMC4912393 - DOI: 10.1097/MCA.0000000000000370

  • Minami Y, Wang Z, Aguirre AD, Lee S, Uemura S, Soeda T, Vergallo R, Raffel OC, Barlis P, Itoh T, Lee H, Fujimoto J, Jang IK Quantitative analysis of the side-branch orifice after bifurcation stenting using en-face processing of OCT images: a comparison between Xience V and Resolute Integrity stents. Coron Artery Dis. 2015;27(1):19-28 - PMID: 26554662 - PMCID: PMC4679565 - DOI: 10.1097/MCA.0000000000000319

  • Vinegoni C, Aguirre AD, Lee S, Weissleder R Imaging the beating heart in the mouse using intravital microscopy techniques. Nat Protoc. 2015;10(11):1802-1819 - PMID: 26492138 - PMCID: PMC5380003 - DOI: 10.1038/nprot.2015.119

  • Vinegoni C, Lee S, Aguirre AD, Weissleder R New techniques for motion-artifact-free in vivo cardiac microscopy. Front Physiol. 2015;6:147 - PMID: 26029116 - PMCID: PMC4428079 - DOI: 10.3389/fphys.2015.00147

  • Aguirre AD, Vinegoni C, Sebas M, Weissleder R Intravital imaging of cardiac function at the single-cell level. Proc Natl Acad Sci U S A. 2014;111(31):11257-62 - PMID: 25053815 - PMCID: PMC4128110 - DOI: 10.1073/pnas.1401316111

  • Liong M, Im H, Majmudar MD, Aguirre AD, Sebas M, Lee H*, Weissleder R* Magnetic Ligation Method for Quantitative Detection of MicroRNAs. Adv Healthc Mater. 2014;3(7):1015-9 - PMID: 24532323 - PMCID: PMC4107040 - DOI: 10.1002/adhm.201300672