Case 6-2024: A 21-Year-Old Man with Fatigue and Night Sweats.
N Engl J Med. 2024;390(8):747-756 - PMID: 38381678 - DOI: 10.1056/NEJMcpc2309498
Haematological setpoints are a stable and patient-specific deep phenotype.
Nature. 2024;637(8045):430-438 - PMID: 39663453 - PMCID: PMC12085991 - DOI: 10.1038/s41586-024-08264-5
Resilient anatomy and local plasticity of naive and stress haematopoiesis.
Nature. 2024;627(8005):839-846 - PMID: 38509363 - PMCID: PMC10972750 - DOI: 10.1038/s41586-024-07186-6
Spatial oncology: Translating contextual biology to the clinic.
Cancer Cell. 2024;42(10):1653-1675 - PMID: 39366372 - PMCID: PMC12051486 - DOI: 10.1016/j.ccell.2024.09.001
Integrating priorities at the intersection of cancer and neuroscience.
Cancer Cell. 2024;43(1):1-5 - PMID: 39423816 - PMCID: PMC11732710 - DOI: 10.1016/j.ccell.2024.09.014
Amplifying mutational profiling of extracellular vesicle mRNA with SCOPE.
Nat Biotechnol. 2024;43(9):1485-1495 - PMID: 39375445 - PMCID: PMC12747296 - DOI: 10.1038/s41587-024-02426-6
Transcripts of repetitive DNA elements signal to block phagocytosis of hematopoietic stem cells.
Science. 2024;385(6714):eadn1629 - PMID: 39264994 - PMCID: PMC12012832 - DOI: 10.1126/science.adn1629
Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment.
Nat Genet. 2024;56(11):2466-2478 - PMID: 39227743 - PMCID: PMC11816915 - DOI: 10.1038/s41588-024-01890-9
Deep profiling of gene expression across 18 human cancers.
Nat Biomed Eng. 2024;9(3):333-355 - PMID: 39690287 - DOI: 10.1038/s41551-024-01290-8
Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss.
Cell Metab. 2024;36(4):857-876.e10 - PMID: 38569472 - DOI: 10.1016/j.cmet.2024.02.007
Virus-Induced Acute Respiratory Distress Syndrome Causes Cardiomyopathy Through Eliciting Inflammatory Responses in the Heart.
Circulation. 2024;150(1):49-61 - PMID: 38506045 - PMCID: PMC11216864 - DOI: 10.1161/CIRCULATIONAHA.123.066433
Inhibiting the Keap1/Nrf2 Protein-Protein Interaction with Protein-Like Polymers.
Sustained and Localized Drug Depot Release using Radiation-Activated Scintillating Nanoparticles.
The aged tumor microenvironment limits T cell control of cancer.
Nat Immunol. 2024;25(6):1033-1045 - PMID: 38745085 - PMCID: PMC11500459 - DOI: 10.1038/s41590-024-01828-7
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate.
Cell Stem Cell. 2024;31(3):359-377.e10 - PMID: 38458178 - PMCID: PMC10957094 - DOI: 10.1016/j.stem.2024.02.004
Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors.
Nat Cancer. 2024;5(11):1681-1696 - PMID: 39406916 - PMCID: PMC11584400 - DOI: 10.1038/s43018-024-00840-y
Phase-driven progress in nanophotonic biosensing.
Light Sci Appl. 2024;13(1):76 - PMID: 38494520 - PMCID: PMC10944832 - DOI: 10.1038/s41377-024-01415-3
Magnetic Silica-Coated Fluorescent Microspheres (MagSiGlow) for Simultaneous Detection of Tumor-Associated Proteins.
Angew Chem Int Ed Engl. 2024;63(24):e202318870 - PMID: 38578432 - PMCID: PMC11998990 - DOI: 10.1002/anie.202318870
Estimating Glycemia From HbA1c and CGM: Analysis of Accuracy and Sources of Discrepancy.
Identification of a Polypeptide Inhibitor of O-GlcNAc Transferase with Picomolar Affinity.
J Am Chem Soc. 2024;146(38):26320-26330 - PMID: 39276112 - PMCID: PMC11440498 - DOI: 10.1021/jacs.4c08656
Extracellular vesicle isolation and counting system (EVics) based on simultaneous tandem tangential flow filtration and large field-of-view light scattering.
J Extracell Vesicles. 2024;13(7):e12479 - PMID: 38978321 - PMCID: PMC11231039 - DOI: 10.1002/jev2.12479
A perspective from the National Eye Institute Extracellular Vesicle Workshop: Gaps, needs, and opportunities for studies of extracellular vesicles in vision research.
J Extracell Vesicles. 2024;13(12):e70023 - PMID: 39665315 - PMCID: PMC11635481 - DOI: 10.1002/jev2.70023
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
A non-lipid nucleic acid delivery vector with dendritic cell tropism and stimulation.
Empowering the on-site detection of nucleic acids by integrating CRISPR and digital signal processing.
Tau propagation in the brain olfactory circuits is associated with smell perception changes in aging.
Molecular fingerprinting of biological nanoparticles with a label-free optofluidic platform.
Targeted SPP1 Inhibition of Tumor-Associated Myeloid Cells Effectively Decreases Tumor Sizes.
Adv Sci (Weinh). 2024;12(4):e2410360 - PMID: 39639496 - PMCID: PMC11775521 - DOI: 10.1002/advs.202410360
Live Organoid Cyclic Imaging.
Adv Sci (Weinh). 2024;11(14):e2309289 - PMID: 38326078 - PMCID: PMC11005682 - DOI: 10.1002/advs.202309289
Pharmacological Polarization of Tumor-Associated Macrophages Toward a CXCL9 Antitumor Phenotype.
Adv Sci (Weinh). 2024;11(15):e2309026 - PMID: 38342608 - PMCID: PMC11022742 - DOI: 10.1002/advs.202309026
Lipid Nanoparticle-mRNA Engineered Dendritic Cell Based Adoptive Cell Therapy Enhances Cancer Immune Response.
Small Methods. 2024;9(1):e2400633 - PMID: 39039995 - PMCID: PMC11740962 - DOI: 10.1002/smtd.202400633
Novel lateral flow assay to detect H2O2 by utilizing self-biotinylation of G-quadruplex.
Biosens Bioelectron. 2024;267:116811 - PMID: 39378787 - DOI: 10.1016/j.bios.2024.116811
Extended Pharmacokinetics Improve Site-Specific Prodrug Activation Using Radiation.
ACS Cent Sci. 2024;10(7):1371-1382 - PMID: 39071065 - PMCID: PMC11273447 - DOI: 10.1021/acscentsci.4c00354
Macrophages coordinate immune response to laser-induced injury via extracellular traps.
J Neuroinflammation. 2024;21(1):68 - PMID: 38500151 - PMCID: PMC10949579 - DOI: 10.1186/s12974-024-03064-0
Lessons learned from phase 3 trials of immunotherapy for glioblastoma: Time for longitudinal sampling?
Oncolytic immunoactivation associates with survival in a glioblastoma clinical trial.
Stem Cell-Derived Extracellular Vesicle-Bearing Injectable Hydrogel for Collagen Generation in Dermis.
ACS Appl Mater Interfaces. 2024;16(29):37698-37706 - PMID: 38980897 - PMCID: PMC13010992 - DOI: 10.1021/acsami.4c07434
Upconverting Nanoparticle-based Enhanced Luminescence Lateral-Flow Assay for Urinary Biomarker Monitoring.
ACS Appl Mater Interfaces. 2024;16(29):38243-38251 - PMID: 38980927 - PMCID: PMC13236632 - DOI: 10.1021/acsami.4c06117
Super High Contrast USPIO-Enhanced Cerebrovascular Angiography Using Ultrashort Time-to-Echo MRI.
Int J Biomed Imaging. 2024;2024:9763364 - PMID: 38644981 - PMCID: PMC11032209 - DOI: 10.1155/2024/9763364
Host-functionalization of macrin nanoparticles to enable drug loading and control tumor-associated macrophage phenotype
Frontiers in Immunology (molecular innate immunity section). 2024;15:1331480 - PMID: 38545103 - PMCID: PMC10965546 - DOI: 10.3389/fimmu.2024.1331480
PARP trapping is governed by the PARP inhibitor dissociation rate constant.
Cell Chem Biol. 2024;31(7):1373-1382.e10 - PMID: 38262416 - PMCID: PMC11259578 - DOI: 10.1016/j.chembiol.2023.12.019
The cyclimids: Degron-inspired cereblon binders for targeted protein degradation.
Cell Chem Biol. 2024;31(6):1162-1175.e10 - PMID: 38320555 - PMCID: PMC12136240 - DOI: 10.1016/j.chembiol.2024.01.003
What is chemical biology?
Cell Chem Biol. 2024;31(9):1562-1565 - PMID: 39303695 - DOI: 10.1016/j.chembiol.2024.08.011
Aging Intensifies Myeloperoxidase Activity after Ischemic Stroke.
The R's of Radiation Therapy: Do We Need More or Do We Move On?
Int J Radiat Oncol Biol Phys. 2024;119(3):734-736 - PMID: 38851274 - DOI: 10.1016/j.ijrobp.2024.02.008
Tuning Into Immune Cell Responses of Chronic Stress With Intravital Microscopy.
Arterioscler Thromb Vasc Biol. 2024;44(12):2507-2508 - PMID: 39445423 - DOI: 10.1161/ATVBAHA.124.321865
Targeting heterogeneous tumor microenvironments in pancreatic cancer mouse models of metastasis by TGFβ depletion.
JCI Insight. 2024;9(21):ePub - PMID: 39298276 - PMCID: PMC11610749 - DOI: 10.1172/jci.insight.182766
Ocular Effects of MEK Inhibitor Therapy: Literature Review, Clinical Presentation, and Best Practices for Mitigation.
Oncologist. 2024;29(5):e616-e621 - PMID: 38527005 - PMCID: PMC11067803 - DOI: 10.1093/oncolo/oyae014
Probing the glioma micro-environment: analysis using biopsy in combination with ultra-fast cyclic immunolabeling.
Targeting Myeloperoxidase to Reduce Neuroinflammation in X-Linked Dystonia Parkinsonism.
CNS Neurosci Ther. 2024;30(11):e70109 - PMID: 39500625 - PMCID: PMC11537767 - DOI: 10.1111/cns.70109
Cellular calcium handling and electrophysiology are modulated by chronic physiological pacing in human induced pluripotent stem cell-derived cardiomyocytes.
Am J Physiol Heart Circ Physiol. 2024;327(5):H1244-H1254 - PMID: 39302711 - DOI: 10.1152/ajpheart.00536.2024
Evaluating the added value of concurrent contrast-enhanced diagnostic CT for PSMA-PET/CT Interpretation.
Acad Radiol. 2024;32(1):275-286 - PMID: 39147641 - PMCID: PMC12173529 - DOI: 10.1016/j.acra.2024.08.008
Deep learning pipeline for automated cell profiling from cyclic imaging
Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia.
Phase 1b study of mirvetuximab soravtansine, a folate receptor alpha (FRα)-targeting antibody-drug conjugate, in combination with carboplatin and bevacizumab in patients with platinum-sensitive ovarian cancer.
Gynecol Oncol. 2024;185:186-193 - PMID: 38447347 - DOI: 10.1016/j.ygyno.2024.01.045
Timing of diuretic administration effects on urine volume in hospitalized patients.
Front Physiol. 2024;14:1208324 - PMID: 38321985 - PMCID: PMC10844419 - DOI: 10.3389/fphys.2023.1208324
Scission-Enhanced Molecular Imaging (SEMI).
Bioconjug Chem. 2024;35(10):1543-52 - PMID: 39255972 - PMCID: PMC11488501 - DOI: 10.1021/acs.bioconjchem.4c00337
FAP-Targeted Fluorescent Imaging Agents to Study Cancer-Associated Fibroblasts In Vivo.
Bioconjug Chem. 2024;36(1):44-53 - PMID: 39667730 - PMCID: PMC11740949 - DOI: 10.1021/acs.bioconjchem.4c00426
γ-Butyrolactone derivatives of MSA-2 are STING prodrugs
ChemMedChem. 2024;19(19):e202400416 - PMID: 38887174 - PMCID: PMC11979874 - DOI: 10.1002/cmdc.202400416
CRISPR/Cas13a-assisted amplification-free miRNA biosensor via dark-field imaging and magnetic gold nanoparticles.
Barriers and facilitators of retention in care after cervical cancer screening: patients' and healthcare providers' perspectives.
BMC Womens Health. 2024;24(1):516 - PMID: 39272088 - PMCID: PMC11401415 - DOI: 10.1186/s12905-024-03343-1
Monocyte Anisocytosis is Associated with Sepsis in Children with Suspected Infection.
Prevalence of cervical intraepithelial lesions and associated factors among women attending a cervical cancer clinic in Western Uganda; results based on Pap smear cytology.
SAGE Open Med. 2024;12:20503121241252265 - PMID: 38764539 - PMCID: PMC11100407 - DOI: 10.1177/20503121241252265
Hypofractionated Radiotherapy-Related Lymphopenia Is Associated With Worse Survival in Unresectable Intrahepatic Cholangiocarcinoma.
Am J Clin Oncol. 2024;47(8):373-382 - PMID: 38767086 - PMCID: PMC12413688 - DOI: 10.1097/COC.0000000000001108
Ethical principles for practice building in the era of targeted radioligand therapy.
Clin Imaging. 2024;116:110334 - PMID: 39488932 - DOI: 10.1016/j.clinimag.2024.110334
Basic Science of Neuroinflammation and Involvement of the Inflammatory Response in Disorders of the Nervous System.
Magn Reson Imaging Clin N Am. 2024;32(2):375-384 - PMID: 38555147 - PMCID: PMC10987041 - DOI: 10.1016/j.mric.2024.01.003
The diagnostic accuracy of serum and plasma microRNAs in detection of cervical intraepithelial neoplasia and cervical cancer: A systematic review and meta-analysis.
Gynecol Oncol Rep. 2024;54:101424 - PMID: 38939506 - PMCID: PMC11208915 - DOI: 10.1016/j.gore.2024.101424
Therapeutic Spp1 silencing in TREM2 + cardiac macrophages suppresses atrial fibrillation.
Targeting myeloperoxidase to reduce neuroinflammation in X-linked dystonia parkinsonism.
A unique interplay of access and selection shapes peritoneal metastasis evolution in colorectal cancer.
Protocol for the comprehensive biochemical and cellular profiling of small-molecule degraders using CoraFluor TR-FRET technology.
STAR Protoc. 2024;5(2):103129 - PMID: 38857155 - PMCID: PMC11193044 - DOI: 10.1016/j.xpro.2024.103129
Ex Vivo Machine Perfusion as a Platform for Lentiviral Gene Delivery in Rat Livers.
Asymmetric Engagement of Dimeric CRL3 KBTBD4 by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes.
KBTBD4 Cancer Hotspot Mutations Drive Neomorphic Degradation of HDAC1/2 Corepressor Complexes.
Localized in vivo prodrug activation using radionuclides.