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Finn KM, Sutphin PD, Carlson JCT, Raskin KA, Van Cott EM
Case 17-2021: An 82-Year-Old Woman with Pain, Swelling, and Ecchymosis of the Left Arm.
N Engl J Med. 2021;384(23):2242-2250 - PMID: 34107184 - DOI: 10.1056/NEJMcpc2100281
Choi S, Zhang B, Ma S, Gonzalez-Celeiro M, Stein D, Jin X, Kim ST, Kang YL, Besnard A, Rezza A, Grisanti L, Buenrostro JD, Rendl M, Nahrendorf M, Sahay A, Hsu YC
Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence
Nature. 2021;592(7854):428-432 - PMID: 33790465 - DOI: 10.1038/s41586-021-03417-2
Griffin GK, Wu J, Iracheta-Vellve A, Patti JC, Hsu J, Davis T, Dele-Oni D, Du PP, Halawi AG, Ishizuka JJ, Kim SY, Klaeger S, Knudsen NH, Miller BC, Nguyen TH, Olander KE, Papanastasiou M, Rachimi S, Robitschek EJ, Schneider EM, Yeary MD, Zimmer MD, Jaffe JD, Carr SA, Doench JG, Haining WN, Yates KB, Manguso RT, Bernstein BE
Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity.
Nature. 2021;595(7866):309-314 - PMID: 33953401 - DOI: 10.1038/s41586-021-03520-4
McAlpine CS, Park J, Griciuc A, Kim E, Choi SH, Iwamoto Y, Kiss MG, Christie KA, Vinegoni C, Poller WC, Mindur JE, Chan CT, He S, Janssen H, Wong LP, Downey J, Singh S, Anzai A, Kahles F, Jorfi M, Feruglio PF, Sadreyev RI, Weissleder R, Kleinstiver BP, Nahrendorf M, Tanzi RE, Swirski FK
Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease
Nature. 2021;595(7869):701-706 - PMID: 34262178 - DOI: 10.1038/s41586-021-03734-6
Naxerova K
Mutation fingerprints encode cellular histories.
Nature. 2021;597(7876):334-336 - PMID: 34433973
Shareef SJ, Bevill SM, Raman AT, Aryee MJ, van Galen P, Hovestadt V, Bernstein BE
Extended-representation bisulfite sequencing of gene regulatory elements in multiplexed samples and single cells.
Nat Biotechnol. 2021;39(9):1086-1094 - PMID: 33958785 - PMCID: PMC8434949 - DOI: 10.1038/s41587-021-00910-x
Heyde A, Rohde D, McAlpine CS, Zhang S, Hoyer FF, Gerold JM, Cheek D, Iwamoto Y, Schloss MJ, Vandoorne K, Iborra-Egea O, Muñoz-Guijosa C, Bayes-Genis A, Reiter JG, Craig M, Swirski FK, Nahrendorf M, Nowak MA, Naxerova K
Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis
Cell. 2021;184:1-14 - PMID: 33636128 - PMCID: PMC8109274 - DOI: 10.1016/j.cell.2021.01.049
Nuñez JK, Chen J, Pommier GC, Cogan JZ, Replogle JM, Adriaens C, Ramadoss GN, Shi Q, Hung KL, Samelson AJ, Pogson AN, Kim JYS, Chung A, Leonetti MD, Chang HY, Kampmann M, Bernstein BE, Hovestadt V, Gilbert LA, Weissman JS
Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing.
Cell. 2021;184(9):2503-2519.e17 - PMID: 33838111 - PMCID: PMC8376083 - DOI: 10.1016/j.cell.2021.03.025
Li R, Ng TSC, Wang SJ, Prytyskach M, Rodell CB, Mikula H, Kohler RH, Garlin MA, Lauffenburger DA, Parangi S, Dinulescu DM, Bardeesy N, Weissleder R, Miller MA
Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer
Nat Nanotechnol. 2021;16(7):830-839 - PMID: 33958764 - PMCID: PMC8491539 - DOI: 10.1038/s41565-021-00897-1
Nahrendorf M
Response by Nahrendorf to Letter Regarding Article, "Bone Marrow Endothelial Cells Regulate Myelopoiesis in Diabetes Mellitus".
Circulation. 2021;143(2):e7-e8 - PMID: 33428432 - PMCID: PMC7939058 - DOI: 10.1161/CIRCULATIONAHA.120.051633
Hinterdobler J, Schott S, Jin H, Meesmann A, Steinsiek AL, Zimmermann AS, Wobst J, Müller P, Mauersberger C, Vilne B, Baecklund A, Chen CS, Moggio A, Braster Q, Molitor M, Krane M, Kempf WE, Ladwig KH, Hristov M, Hulsmans M, Hilgendorf I, Weber C, Wenzel P, Scheiermann C, Maegdefessel L, Soehnlein O, Libby P, Nahrendorf M, Schunkert H, Kessler T, Sager HB
Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis.
Eur Heart J. 2021;42(39):4077-4088 - PMID: 34279021 - DOI: 10.1093/eurheartj/ehab371
Stiekema LCA, Willemsen L, Kaiser Y, Prange KHM, Wareham NJ, Boekholdt SM, Kuijk C, de Winther MPJ, Voermans C, Nahrendorf M, Stroes ESG, Kroon J
Impact of cholesterol on proinflammatory monocyte production by the bone marrow.
Eur Heart J. 2021;:ePub - PMID: 34343254
Bajpai G, Nahrendorf M
Infectious and lifestyle modifiers of immunity and host resilience.
Immunity. 2021;54(6):1110-1122 - PMID: 34107270 - DOI: 10.1016/j.immuni.2021.05.011
Park J, Park JS, Huang CH, Jo A, Cook K, Wang R, Lin HY, Van Deun J, Li H, Min J, Wang L, Yoon G, Carter BS, Balaj L, Choi GS, Castro CM, Weissleder R, Lee H
An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma
Nat Biomed Eng. 2021;5(7):678-689 - PMID: 34183802 - PMCID: PMC8437135 - DOI: 10.1038/s41551-021-00752-7
Nahrendorf M
Innate Lymphoid Cells Participate in Myocardial Inflammation After Ischemia.
J Am Coll Cardiol. 2021;78(11):1143-1144 - PMID: 34503683
Aguirre AD, Arbab-Zadeh A, Soeda T, Fuster V, Jang IK
Optical Coherence Tomography of Plaque Vulnerability and Rupture: JACC Focus Seminar Part 1/3.
J Am Coll Cardiol. 2021;78(12):1257-1265 - PMID: 34531027
van Leent MMT, Beldman TJ, Toner YC, Lameijer MA, Rother N, Bekkering S, Teunissen AJP, Zhou X, van der Meel R, Malkus J, Nauta SA, Klein ED, Fay F, Sanchez-Gaytan BL, Pérez-Medina C, Kluza E, Ye YX, Wojtkiewicz G, Fisher EA, Swirski FK, Nahrendorf M, Zhang B, Li Y, Zhang B, Joosten LAB, Pasterkamp G, Boltjes A, Fayad ZA, Lutgens E, Netea MG, Riksen NP, Mulder WJM, Duivenvoorden R
Prosaposin mediates inflammation in atherosclerosis.
Sci Transl Med. 2021;13(584):ePub - PMID: 33692130 - PMCID: PMC8209679 - DOI: 10.1126/scitranslmed.abe1433
Garris CS, Wong JL, Ravetch JV, Knorr DA
Dendritic cell targeting with Fc-enhanced CD40 antibody agonists induces durable antitumor immunity in humanized mouse models of bladder cancer.
Sci Transl Med. 2021;13(594):ePub - PMID: 34011627 - PMCID: PMC8325152 - DOI: 10.1126/scitranslmed.abd1346
Wang Z, Shin J, Park JH, Lee H, Kim DH, Liu H
Engineering Materials for Electrochemical Sweat Sensing
Adv Funct Mater. 2021;:ePub - DOI: 10.1002/adfm.202008130
Grune J, Yamazoe M, Nahrendorf M
Electroimmunology and cardiac arrhythmia.
Nat Rev Cardiol. 2021;18(8):547-564 - PMID: 33654273 - DOI: 10.1038/s41569-021-00520-9
Ko J*, Wang Y*, Sheng K, Weitz DA, Weissleder R
Sequencing-Based Protein Analysis of Single Extracellular Vesicles
ACS Nano. 2021;15(3):5631-5638 - PMID: 33687214 - DOI: 10.1021/acsnano.1c00782
Oh J, Carlson JCT, Landeros C, Lee H, Ferguson S, Faquin WC, Clark JR, Pittet MJ, Pai SI, Weissleder R
Rapid serial immunoprofiling of the tumor immune microenvironment by fine needle sampling
Clin Cancer Res. 2021;27(17):4781-4793 - PMID: 34233961 - PMCID: PMC8416923 - DOI: 10.1158/1078-0432.CCR-21-1252
Koch PD, Quintana J, Ahmed MS, Kohler RH, Weissleder R
Small Molecule Imaging Agent for Mutant KRAS G12C
Advanced Therapeutics. 2021;:2000290 - DOI: 10.1002/adtp.202000290
Oki T, Mercier F, Kato H, Jung Y, McDonald TO, Spencer JA, Mazzola MC, van Gastel N, Lin CP, Michor F, Kitamura T, Scadden DT
Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML.
Nat Commun. 2021;12(1):245 - PMID: 33431855 - PMCID: PMC7801403 - DOI: 10.1038/s41467-020-20491-8
Stewart-Ornstein J, Iwamoto Y, Miller MA, Prytyskach MA, Ferretti S, Holzer P, Kallen J, Furet P, Jambhekar A, Forrester WC, Weissleder R, Lahav G
p53 dynamics vary between tissues and are linked with radiation sensitivity
Nat Commun. 2021;12(1):898 - PMID: 33563973 - PMCID: PMC7873198 - DOI: 10.1038/s41467-021-21145-z
Bénard A, Jacobsen A, Brunner M, Krautz C, Klösch B, Swierzy I, Naschberger E, Podolska MJ, Kouhestani D, David P, Birkholz T, Castellanos I, Trufa D, Sirbu H, Vetter M, Kremer AE, Hildner K, Hecker A, Edinger F, Tenbusch M, Mühl-Zürbes P, Steinkasserer A, Richter E, Streeck H, Berger MM, Brenner T, Weigand MA, Swirski FK, Schett G, Grützmann R, Weber GF
Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections.
Nat Commun. 2021;12(1):1112 - PMID: 33602937 - PMCID: PMC7893044 - DOI: 10.1038/s41467-021-21310-4
Gerhard GM, Bill R, Messemaker M, Klein AM, Pittet MJ
Tumor-infiltrating dendritic cell states are conserved across solid human cancers.
J Exp Med. 2021;218(1):ePub - PMID: 33601412 - PMCID: PMC7754678 - DOI: 10.1084/jem.20200264
Zhang Y, Kohrn BF, Yang M, Nachmanson D, Soong TR, Lee IH, Tao Y, Clevers H, Swisher EM, Brentnall TA, Loeb LA, Kennedy SR, Salk JJ, Naxerova K, Risques RA
PolyG-DS: An ultrasensitive polyguanine tract-profiling method to detect clonal expansions and trace cell lineage.
Proc Natl Acad Sci U S A. 2021;118(31):ePub - PMID: 34330826 - PMCID: PMC8346827
Ryu WS, Schellingerhout D, Hong KS, Jeong SW, Kim BJ, Kim JT, Lee KB, Park TH, Park SS, Park JM, Kang K, Cho YJ, Park HK, Lee BC, Yu KH, Oh MS, Lee SJ, Kim JG, Cha JK, Kim DH, Lee J, Han MK, Park MS, Choi KH, Nahrendorf M, Lee J, Bae HJ, Kim DE
Relation of Pre-stroke Aspirin Use With Cerebral Infarct Volume and Functional Outcomes.
Ann Neurol. 2021;:ePub - PMID: 34536234
Lee CY, Degani I, Cheong J, Lee JH, Choi HJ, Cheon J, Lee H
Fluorescence polarization system for rapid COVID-19 diagnosis
Biosens Bioelectron. 2021;178:113049 - PMID: 33540323 - PMCID: PMC7846465 - DOI: 10.1016/j.bios.2021.113049
Choi JH, Chin LK, Woo BM, Song Y, Seol MJ, Hong Y, Liu AQ, Jang S, Ploegh H, Im H, Lee D
Hydrogel-Based Stamping Technology for Solution-Free Blood Cell Staining.
ACS Appl Mater Interfaces. 2021;13(19):22124-22130 - PMID: 33870697 - DOI: 10.1021/acsami.0c22521
Arlauckas S, Oh N, Li R, Weissleder R, Miller MA
Macrophage imaging and subset analysis using single-cell RNA sequencing.
Nanotheranostics. 2021;5(1):36-56 - PMID: 33391974 - PMCID: PMC7738942 - DOI: 10.7150/ntno.50185
Siwicki M, Gort-Freitas NA, Messemaker M, Bill R, Gungabeesoon J, Engblom C, Zilionis R, Garris C, Gerhard GM, Kohl A, Lin Y, Zou AE, Cianciaruso C, Bolli E, Pfirschke C, Lin YJ, Piot C, Mindur JE, Talele N, Kohler RH, Iwamoto Y, Mino-Kenudson M, Pai SI, deVito C, Koessler T, Merkler D, Coukos A, Wicky A, Fraga M, Sempoux C, Jain RK, Dietrich PY, Michielin O, Weissleder R, Klein AM, Pittet MJ
Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy.
Sci Immunol. 2021;6(61):ePub - PMID: 34215680 - DOI: 10.1126/sciimmunol.abi7083
Barrett TJ, Corr EM, van Solingen C, Schlamp F, Brown EJ, Koelwyn GJ, Lee AH, Shanley LC, Spruill TM, Bozal F, de Jong A, Newman AAC, Drenkova K, Silvestro M, Ramkhelawon B, Reynolds HR, Hochman JS, Nahrendorf M, Swirski FK, Fisher EA, Berger JS, Moore KJ
Chronic stress primes innate immune responses in mice and humans.
Cell Rep. 2021;36(10):109595 - PMID: 34496250 - PMCID: PMC8493594
Wang C, Cheng D, Jalali Motlagh N, Kuellenberg EG, Wojtkiewicz GR, Schmidt SP, Stocker R, Chen JW
Highly Efficient Activatable MRI Probe to Sense Myeloperoxidase Activity.
J Med Chem. 2021;64(9):5874-5885 - PMID: 33945286 - DOI: 10.1021/acs.jmedchem.1c00038
Rohde D, Nahrendorf M
Bad company: monocytes in HIV and atherosclerosis.
Cardiovasc Res. 2021;117(4):993-994 - PMID: 33693568 - PMCID: PMC7982997 - DOI: 10.1093/cvr/cvab058
Powe CE, James K, Higgins JM
Response to Letter to the Editor from Marie Monlun: "Longitudinal changes in the relationship between Hemoglobin A1c and glucose tolerance across pregnancy and post-partum".
J Clin Endocrinol Metab. 2021;106(1):e401-e402 - PMID: 32589732 - PMCID: PMC7765642 - DOI: 10.1210/clinem/dgaa402
Calcagno DM, Zhang C, Toomu A, Huang K, Ninh VK, Miyamoto S, Aguirre AD, Fu Z, Heller Brown J, King KR
SiglecF(HI) Marks Late-Stage Neutrophils of the Infarcted Heart: A Single-Cell Transcriptomic Analysis of Neutrophil Diversification.
J Am Heart Assoc. 2021;10(4):e019019 - PMID: 33525909 - PMCID: PMC7955351 - DOI: 10.1161/JAHA.120.019019
Demers M, Sturtevant S, Guertin KR, Gupta D, Desai K, Vieira BF, Li W, Hicks A, Ismail A, Gonçalves BP, Di Caprio G, Schonbrun E, Hansen S, Musayev FN, Safo MK, Wood DK, Higgins JM, Light DR
MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease.
Blood Adv. 2021;5(5):1388-1402 - PMID: 33661300 - PMCID: PMC7948285 - DOI: 10.1182/bloodadvances.2020003670
Ong CS, Reinertsen E, Sun H, Moonsamy P, Mohan N, Funamoto M, Kaneko T, Shekar PS, Schena S, Lawton JS, D'Alessandro DA, Westover MB, Aguirre AD, Sundt TM
Prediction of operative mortality for patients undergoing cardiac surgical procedures without established risk scores.
J Thorac Cardiovasc Surg. 2021;:ePub - PMID: 34607725
Hou J, Lin CP, Intini G
Activation of creER recombinase in the mouse calvaria induces local recombination without effects on distant skeletal segments.
Sci Rep. 2021;11(1):8214 - PMID: 33859263 - PMCID: PMC8050205 - DOI: 10.1038/s41598-021-87611-2
Mattox AK, Roelands J, Saal TM, Cheng Y, Rinchai D, Hendrickx W, Young GD, Diefenbach TJ, Berger AE, Westra WH, Bishop JA, Faquin WC, Marincola FM, Pittet MJ, Bedognetti D, Pai SI
Myeloid cells are enriched in tonsillar crypts providing insight into the host tropism of HPV.
Am J Pathol. 2021;191(10):1774-1786 - PMID: 34303699 - PMCID: PMC8491092
Koch PD, Quintana J, Ahmed M, Kohler RH, Weissleder R
Small Molecule Imaging Agent For Mutant Kras G12C
Adv Ther (Weinh). 2021;4(5):ePub - PMID: 33997272 - PMCID: PMC8115719 - DOI: 10.1002/adtp.202000290
El-Awady R, Saleh E, Hamoudi R, Ramadan WS, Mazitschek R, Nael MA, Elokely KM, Abou-Gharbia M, Childers WE, Srinivasulu V, Aloum L, Menon V, Al-Tel TH
Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents.
Bioorg Med Chem. 2021;42:116251 - PMID: 34116381 - DOI: 10.1016/j.bmc.2021.116251
Wu JW, Jung Y, Yeh SA, Seo Y, Runnels JM, Burns CS, Mizoguchi T, Ito K, Spencer JA, Lin CP
Intravital fluorescence microscopy with negative contrast.
PLoS ONE. 2021;16(8):e0255204 - PMID: 34351959 - PMCID: PMC8341626
Sandoval DR, Clausen TM, Nora C, Cribbs AP, Denardo A, Clark AE, Garretson AF, Coker JKC, Narayanan A, Majowicz SA, Philpott M, Johansson C, Dunford JE, Spliid CB, Golden GJ, Payne NC, Tye MA, Nowell CJ, Griffis ER, Piermatteo A, Grunddal KV, Alle T, Magida JA, Hauser BM, Feldman J, Caradonna TM, Pu Y, Yin X, McVicar RN, Kwong EM, Weiss RJ, Downes M, Tsimikas S, Smidt AG, Ballatore C, Zengler K, Evans RM, Chanda SK, Croker BA, Leibel SL, Jose J, Mazitschek R, Oppermann U, Esko JD, Carlin AF, Gordts PLSM
The Prolyl-tRNA Synthetase Inhibitor Halofuginone Inhibits SARS-CoV-2 Infection.
bioRxiv. 2021;:ePub - PMID: 33791697 - PMCID: PMC8010724 - DOI: 10.1101/2021.03.22.436522
Deyell M, Garris CS, Laughney AM
Cancer metastasis as a non-healing wound.
Br J Cancer. 2021;124(9):1491-1502 - PMID: 33731858 - PMCID: PMC8076293 - DOI: 10.1038/s41416-021-01309-w
Bill R, Deschler DG, Pittet MJ, Pai SI, Sadow PM, Park JC
Diagnostic challenges and successful organ-preserving therapy in a case of secretory carcinoma of minor salivary glands.
Cancer Rep (Hoboken). 2021;:e1491 - PMID: 34231337 - DOI: 10.1002/cnr2.1491
Foy BH, Sundt T, Carlson JCT, Aguirre AD, Higgins JM
White Blood Cell and Platelet Dynamics Define Human Inflammatory Recovery.
medRxiv. 2021;:ePub - PMID: 34189534 - PMCID: PMC8240689
Ferraro GB, Ali A, Luengo A, Kodack DP, Deik A, Abbott KL, Bezwada D, Blanc L, Prideaux B, Jin X, Possada JM, Chen J, Chin CR, Amoozgar Z, Ferreira R, Chen I, Naxerova K, Ng C, Westermark AM, Duquette M, Roberge S, Lindeman NI, Lyssiotis CA, Nielsen J, Housman DE, Duda DG, Brachtel E, Golub TR, Cantley LC, Asara JM, Davidson SM, Fukumura D, Dartois VA, Clish CB, Jain RK, Vander Heiden MG
Fatty acid synthesis is required for breast cancer brain metastasis.
Nat Cancer. 2021;2(4):414-428 - PMID: 34179825 - PMCID: PMC8223728
Yang Z*, Francisco J*, Reese AS, Spriggs DR, Im H, Castro CM
Addressing cervical cancer screening disparities through advances in artificial intelligence and nanotechnologies for cellular profiling.
Biophysics Review. 2021;2:011303 - PMID: 33842926 - PMCID: PMC8015256 - DOI: 10.1063/5.0043089
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