Evolutionary paths towards metastasis.
Nat Rev Cancer. 2025;25(7):545-560 - PMID: 40263543 - DOI: 10.1038/s41568-025-00814-x
Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations.
Nature. 2025;639(8053):241-249 - PMID: 39939763 - PMCID: PMC11882451 - DOI: 10.1038/s41586-024-08533-3
UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors.
Nature. 2025;639(8053):232-240 - PMID: 39939761 - PMCID: PMC11882444 - DOI: 10.1038/s41586-024-08532-4
Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy.
Nature. 2025;646(8084):462-473 - PMID: 40836096 - PMCID: PMC12406299 - DOI: 10.1038/s41586-025-09370-8
Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity.
Nat Biotechnol. 2025;:ePub - PMID: 41168496 - DOI: 10.1038/s41587-025-02864-w
Advances and challenges in precision imaging
Lancet Oncol. 2025;26:e34-e45 - PMID: 39756454 - PMCID: PMC12117531 - DOI: 10.1016/S1470-2045(24)00395-4
Immune system influence on physiology.
Science. 2025;389(6760):594-599 - PMID: 40773571 - PMCID: PMC12629239 - DOI: 10.1126/science.adx4380
Resistin-like molecule γ attacks cardiomyocyte membranes and promotes ventricular tachycardia.
Science. 2025;389(6764):1043-1048 - PMID: 40906843 - DOI: 10.1126/science.adp7361
Quantifying cell divisions along evolutionary lineages in cancer.
Nat Genet. 2025;57(3):706-717 - PMID: 39905260 - DOI: 10.1038/s41588-025-02078-5
Leducq-funded programme: immune targets for the treatment of atrial fibrillation.
Eur Heart J. 2025;46(25):2369-2371 - PMID: 40326349 - DOI: 10.1093/eurheartj/ehaf176
Targeting immunosuppressive myeloid cells via implant-mediated slow release of small molecules to prevent glioblastoma recurrence
Nat Biomed Eng. 2025;:ePub - PMID: 41125869 - DOI: 10.1038/s41551-025-01533-2
Response by Grune and Nahrendorf to Letter Regarding Article, "Virus-Induced Acute Respiratory Distress Syndrome Causes Cardiomyopathy Through Eliciting Inflammatory Responses in the Heart".
Circulation. 2025;151(5):e35-e36 - PMID: 39899631 - DOI: 10.1161/CIRCULATIONAHA.124.072688
Nanophotonic sensing and label-free imaging of extracellular vesicles.
Light Sci Appl. 2025;14(1):177 - PMID: 40295495 - PMCID: PMC12037801 - DOI: 10.1038/s41377-025-01866-2
Radiation-Triggered Payload Release Enhances Bispecific Antibody Efficacy.
Cancer Res. 2025;:ePub - PMID: 41066595 - DOI: 10.1158/0008-5472.CAN-25-0517
Extracellular Vesicles for Clinical Diagnostics: From Bulk Measurements to Single-Vesicle Analysis.
ACS Nano. 2025;19(31):28021-28109 - PMID: 40720603 - PMCID: PMC12356129 - DOI: 10.1021/acsnano.5c00706
A Myeloid Cell-Targeted Immunostimulant Cocktail (MyTai) Enhances Cancer Immunotherapy.
ACS Nano. 2025;19(41):36451-36464 - PMID: 41061756 - DOI: 10.1021/acsnano.5c10081
Fluorinated Ribonucleocarbohydrate Nanoparticles Allow Ultraefficient mRNA Delivery and Protein Expression in Tumor-Associated Myeloid Cells
J Am Chem Soc. 2025;147(14):11766-11776 - PMID: 40135499 - PMCID: PMC11987029 - DOI: 10.1021/jacs.4c14474
Computationally Designed Nanobinders as Affinity Ligands in Diagnostic and Therapeutic Applications.
J Am Chem Soc. 2025;147(35):32187-32198 - PMID: 40839867 - DOI: 10.1021/jacs.5c11289
Enzyme-Activated Sugar-Coated Bifunctional Degraders.
J Am Chem Soc. 2025;147(38):34672-34680 - PMID: 40937862 - DOI: 10.1021/jacs.5c09843
Engineering of CD63 Enables Selective Extracellular Vesicle Cargo Loading and Enhanced Payload Delivery.
J Extracell Vesicles. 2025;14(6):e70094 - PMID: 40527733 - PMCID: PMC12173531 - DOI: 10.1002/jev2.70094
Strategies for mitigating data heterogeneities in AI-based neuro-disease detection.
Neuron. 2025;113(8):1129-1132 - PMID: 40037359 - DOI: 10.1016/j.neuron.2025.01.028
Novel approaches to clinical trial design in cancer neuroscience.
Neuron. 2025;113(17):2791-2813 - PMID: 40907474 - PMCID: PMC12435926 - DOI: 10.1016/j.neuron.2025.08.015
Platelet-white cell ratio is more strongly associated with mortality than other common risk ratios derived from complete blood counts.
Effective treatment of systemic candidiasis by synergistic targeting of cell wall synthesis.
Recent developments in myeloid immune modulation in cancer therapy.
Trends Cancer. 2025;11(4):365-375 - PMID: 39794212 - DOI: 10.1016/j.trecan.2024.12.003
Blood-derived APLP1+ extracellular vesicles are potential biomarkers for the early diagnosis of brain diseases.
Integrated spatial morpho-transcriptomics predicts functional traits in pancreatic cancer.
Targeting cancer- associated fibroblasts for real- time intraoperative tumor identification with a spray-on fluorescent probe
Epigenetic therapy sensitizes anti-PD-1 refractory head and neck cancers to immunotherapy rechallenge.
A specific and adaptable approach to track CD206+ macrophages by molecular MRI and fluorescence imaging.
Tracking inflammation status for improving patient prognosis: A review of current methods, unmet clinical needs and opportunities.
Biotechnol Adv. 2025;82:108592 - PMID: 40324661 - PMCID: PMC12173025 - DOI: 10.1016/j.biotechadv.2025.108592
Spatial analysis identifies DC niches as predictors of pembrolizumab therapy in head and neck squamous cell cancer
Cell Rep Med. 2025;6(5):102100 - PMID: 40311615 - PMCID: PMC12147904 - DOI: 10.1016/j.xcrm.2025.102100
Differential dementia detection from multimodal brain images in a real-world dataset.
Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1α.
Nat Cardiovasc Res. 2025;4(10):1277-1294 - PMID: 40993371 - DOI: 10.1038/s44161-025-00712-3
B cells promote atrial fibrillation via autoantibodies.
Nat Cardiovasc Res. 2025;4(10):1381-1396 - PMID: 41062615 - PMCID: PMC12520985 - DOI: 10.1038/s44161-025-00724-z
Scalable electrochemical system for rapid on-site detection of food allergens.
Biosens Bioelectron. 2025;273:117142 - PMID: 39832405 - PMCID: PMC11788024 - DOI: 10.1016/j.bios.2025.117142
Bridging laboratory innovation to translational research and commercialization of extracellular vesicle isolation and detection.
Biosens Bioelectron. 2025;282:117475 - PMID: 40300344 - PMCID: PMC12076185 - DOI: 10.1016/j.bios.2025.117475
Building a Medicinal Chemistry Framework for Bioorthogonal Probes.
ACS Cent Sci. 2025;11(6):823-825 - PMID: 40606006 - PMCID: PMC12220826 - DOI: 10.1021/acscentsci.5c00917
Inhibiting Monocyte Migration Reduces Arterial Thrombosis and Facilitates Thrombolysis.
Stroke. 2025;56(12):3438-3453 - PMID: 41070446 - PMCID: PMC12636086 - DOI: 10.1161/STROKEAHA.125.052352
InSituCor: exploring spatially correlated genes conditional on the cell type landscape.
Localized In Vivo Prodrug Activation Using Radionuclides.
A pilot study of [18F]F-fluciclovine positron emission tomography/computed tomography for staging muscle invasive bladder cancer preceding radical cystectomy.
Eur J Nucl Med Mol Imaging. 2025;52(11):4092-4101 - PMID: 40257614 - DOI: 10.1007/s00259-025-07287-y
The contribution of cyclic imide stereoisomers on cereblon-dependent activity.
Effect of bone marrow disease on hematologic toxicity and response to [177Lu]Lu-PSMA-617 therapy: insights from PSMA-PET/CT imaging.
Eur J Nucl Med Mol Imaging. 2025;:ePub - PMID: 40908334 - DOI: 10.1007/s00259-025-07541-3
A method for the detection and enrichment of endogenous cereblon substrates.
Cell Chem Biol. 2025;32(8):1028-1041.e13 - PMID: 40782806 - PMCID: PMC12360616 - DOI: 10.1016/j.chembiol.2025.07.002
Recognizing Early Career Translational Investigators.
JACC Basic Transl Sci. 2025;10(8):101362 - PMID: 40866044 - PMCID: PMC12399141 - DOI: 10.1016/j.jacbts.2025.101362
Unleashing the Power of the Beehive to Begin a New Era for JACC: Basic to Translational Science.
JACC Basic Transl Sci. 2025;10(8):101360 - PMID: 40866039 - PMCID: PMC12399142 - DOI: 10.1016/j.jacbts.2025.101360
On Macrophage Culture.
JACC Basic Transl Sci. 2025;10(9):101375 - PMID: 40992828 - PMCID: PMC12539482 - DOI: 10.1016/j.jacbts.2025.101375
Disruption of P. falciparum amino acid transporter elevates intracellular proline and induces resistance to Prolyl-tRNA synthetase inhibitors.
Cell Chem Biol. 2025;32(10):1293-1302.e5 - PMID: 41061700 - DOI: 10.1016/j.chembiol.2025.09.007
Recognizing Early Career Translational Investigators.
JACC Basic Transl Sci. 2025;10(10):101398 - PMID: 41161898 - PMCID: PMC12665410 - DOI: 10.1016/j.jacbts.2025.101398
Metabolic Memory Resides in the Hematopoietic Marrow and in Arterial Resident Leukocytes.
JACC Basic Transl Sci. 2025;10(10):101392 - PMID: 41161897 - PMCID: PMC12665419 - DOI: 10.1016/j.jacbts.2025.101392
Recognizing Early Career Translational Investigators.
JACC Basic Transl Sci. 2025;10(11):101410 - PMID: 41298046 - DOI: 10.1016/j.jacbts.2025.101410
Neutrophils in Myocardial Infarction.
JACC Basic Transl Sci. 2025;10(11):101408 - PMID: 41298044 - DOI: 10.1016/j.jacbts.2025.101408
Genetically Engineered Organs for Early Reporting of Transplant Rejection.
Mol Ther. 2025;:ePub - PMID: 41088753 - DOI: 10.1016/j.ymthe.2025.10.024
Integrative genomic identification of therapeutic targets for pancreatic cancer.
Cell Rep. 2025;44(9):116191 - PMID: 40848256 - DOI: 10.1016/j.celrep.2025.116191
Spatial Profiling of Elements through Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging.
Anal Chem. 2025;97(45):25334-25345 - PMID: 41201007 - DOI: 10.1021/acs.analchem.5c05632
Video kinematics of an unloaded, ex-vivo beating heart can predict future loaded heart function.
J Heart Lung Transplant. 2025;44(11):1823-1826 - PMID: 40716473 - DOI: 10.1016/j.healun.2025.07.023
Diffraction-informed deep learning for molecular-specific holograms of breast cancer cells.
Serial Circulating Tumor DNA Sequencing to Monitor Response and Define Acquired Resistance to Letrozole/Abemaciclib in Endometrial Cancer.
JCO Precis Oncol. 2025;9:e2400882 - PMID: 40209137 - DOI: 10.1200/PO-24-00882
Noninvasive Quantitative Compression Ultrasound Central Venous Pressure: A Clinical Pilot Study.
Ex vivo machine perfusion as a platform for lentiviral gene delivery in rat livers.
Gene Ther. 2025;32(4):421-429 - PMID: 40263629 - DOI: 10.1038/s41434-025-00536-7
Rethinking migraine with aura: Why cortical spreading depolarization (depression), not aura, causes headaches.
Cephalalgia. 2025;45(9):3331024251370629 - PMID: 40891631 - DOI: 10.1177/03331024251370629
Race and Outcomes to [177Lu]Lu-PSMA-617 in Advanced Prostate Cancer.
Cancers (Basel). 2025;17(12):ePub - PMID: 40563610 - PMCID: PMC12191161 - DOI: 10.3390/cancers17121960
AAV hamartin gene therapy in a stochastic, cerebral mouse model of tuberous sclerosis type 1.
Mol Ther Methods Clin Dev. 2025;33(3):101556 - PMID: 40932991 - PMCID: PMC12419009 - DOI: 10.1016/j.omtm.2025.101556
Safety and efficacy of mirvetuximab soravtansine, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC), in combination with pembrolizumab in patients with platinum-resistant ovarian cancer.
Gynecol Oncol. 2025;200:96-104 - PMID: 40700855 - DOI: 10.1016/j.ygyno.2025.06.016
The State of Paid Family and Medical Leave Policies: An ACR, AAWR, SWRO Member Survey.
J Am Coll Radiol. 2025;22(7):831-837 - PMID: 40174871 - DOI: 10.1016/j.jacr.2025.03.006
Fluorescent PSMA-Targeted Radiotheranostic Compounds for Multiscale Imaging.
Bioconjug Chem. 2025;36(7):1448-1460 - PMID: 40574660 - PMCID: PMC12365983 - DOI: 10.1021/acs.bioconjchem.5c00139
Far-Red Spray-On Imaging Probes for FAP-Targeted Cancer Surgery
Bioconjug Chem. 2025;36(11):2410-2422 - PMID: 41147981 - DOI: 10.1021/acs.bioconjchem.5c00420
Combination metastasis-targeted external beam radiation therapy with 177Lu-PSMA-617 in patients with advanced castration-resistant prostate cancer.
Pract Radiat Oncol. 2025;15(6):e597-e605 - PMID: 40274261 - DOI: 10.1016/j.prro.2025.03.010
An open-source, automated machine learning approach for large-scale image retrieval for thoracic aorta analysis studies.
JAMIA Open. 2025;8(4):ooaf066 - PMID: 40662082 - PMCID: PMC12257624 - DOI: 10.1093/jamiaopen/ooaf066
Cell Confluency Affects p53 Dynamics in Response to DNA Damage.
Risk stratification of chest pain in the emergency department using artificial intelligence applied to electrocardiograms.
Open Heart. 2025;12(2):ePub - PMID: 40889954 - PMCID: PMC12406858 - DOI: 10.1136/openhrt-2025-003343
Outcome of Subsequent Therapies After 177Lu-Vipivotide Tetraxetan for Metastatic Castrate-Resistant Prostate Cancer: A Tertiary Cancer Center Experience.
Prostate. 2025;85(8):742-748 - PMID: 40103237 - DOI: 10.1002/pros.24880
Diagnostic Accuracy of Serum P16ink4A and FOX-P3 Concentrations for Detection of Cervical Lesions Among Women Attending a Cervical Cancer Clinic in Western Uganda: A Case-Control Study.
Anal Cell Pathol (Amst). 2025;2025:1931921 - PMID: 40365511 - PMCID: PMC12074841 - DOI: 10.1155/ancp/1931921
Outcomes of Percutaneous Cystic Duct Stent (PCDS) Placement for Acute Cholecystitis.
J Vasc Interv Radiol. 2025;37(1):107892 - PMID: 41161411 - DOI: 10.1016/j.jvir.2025.10.023
Human Retinal Progenitor Cell (hRPC) Migration in Three-Dimensional (3D) Environments of Varying Stiffness and Composition.
J Tissue Eng Regen Med. 2025;2025:9963972 - PMID: 41195017 - PMCID: PMC12585844 - DOI: 10.1155/term/9963972
Next-Generation Approaches to Improve the Information Content of Interventional Radiology Biopsies.
J Vasc Interv Radiol. 2025;36(12):1856-1861.e1 - PMID: 41276363 - DOI: 10.1016/j.jvir.2025.09.018
Extracellular vesicles in colorectal cancer.
Ann Coloproctol. 2025;41(5):379-392 - PMID: 41158051 - PMCID: PMC12569783 - DOI: 10.3393/ac.2025.00745.0106
Strategies to enhance recruitment in nuclear medicine: A path forward.
Clin Imaging. 2025;125:110572 - PMID: 40752450 - DOI: 10.1016/j.clinimag.2025.110572
The role of PSMA PET/CT in identifying benign and malignant intracranial lesions in patients with prostate cancer.
Clin Imaging. 2025;128:110620 - PMID: 40973568 - DOI: 10.1016/j.clinimag.2025.110620
Design and implementation of a patient management system for coordination of theranostics care at a major referral center.
Clin Imaging. 2025;129:110673 - PMID: 41265114 - DOI: 10.1016/j.clinimag.2025.110673
Enhanced mRNA delivery using ultrasound-delivered click reactive anchors.
Hematologic dynamics during pregnancy and their association with obstetric complications: a retrospective cohort study.
Integrated spatial morpho-transcriptomics predicts functional traits in pancreatic cancer.
Suspension physics govern the multiscale dynamics of blood flow in sickle cell disease.
A method for the detection and enrichment of endogenous cereblon substrates.
Transformer-based artificial intelligence on single-cell clinical data for homeostatic mechanism inference and rational biomarker discovery.
Cardiac Output Estimation in the Intensive Care Unit.
JACC Adv. 2025;4(5):101663 - PMID: 40286350 - PMCID: PMC12101535 - DOI: 10.1016/j.jacadv.2025.101663
Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis.
Quantifying the unique mechanical properties of irreversibly sickled cells in sickle cell disease.
Blood Vessel Thromb Hemost. 2025;2(3):100077 - PMID: 40765910 - PMCID: PMC12320412 - DOI: 10.1016/j.bvth.2025.100077
An Electrocardiogram Foundation Model Built on over 10 Million Recordings.
Distinct malignant cell states and myeloid glutamate signaling associated with aggressive pancreatic neuroendocrine tumors.
The Pdgfd-Pdgfrb axis orchestrates tumor-nerve crosstalk in pancreatic cancer.
In vitro radionuclide labeling characteristics of blenderized tube feeds for quantitative gastric motility assessment.
Age distinguishes selection from causation in cancer genomes.